spinal cord regeneration
Summary: Repair of the damaged neuron function after SPINAL CORD INJURY or SPINAL CORD DISEASES.
Steward O, Sharp K, Matsudaira Yee K. Long-distance migration and colonization of transplanted neural stem cells. Cell. 2014;156:385-7 pubmed publisher
Adeeb N, Mortazavi M. The role of FGF2 in spinal cord trauma and regeneration research. Brain Behav. 2014;4:105-7 pubmed publisher
Ahuja C, Nori S, Tetreault L, Wilson J, Kwon B, Harrop J, et al
. Traumatic Spinal Cord Injury-Repair and Regeneration. Neurosurgery. 2017;80:S9-S22 pubmed publisher
..We conclude with our perspectives on the future of treatment and research in this rapidly evolving field. ..
Povysheva T, Shmarov M, Logunov D, Naroditsky B, Shulman I, Ogurcov S, et al
. Post-spinal cord injury astrocyte-mediated functional recovery in rats after intraspinal injection of the recombinant adenoviral vectors Ad5-VEGF and Ad5-ANG. J Neurosurg Spine. 2017;27:105-115 pubmed publisher
..These results suggest that there may be positive effects of this combination of genes in posttraumatic spinal cord regeneration. The objective of the present study was to determine the effects of Ad5-VEGF+Ad5-ANG combination therapy ..
Wang L, Huang S, Zhao H, Liu C, Yao L, Shen Y. Activating transcription factor 3 promotes spinal cord regeneration of adult zebrafish. Biochem Biophys Res Commun. 2017;488:522-527 pubmed publisher
..These data suggest that ATF3 could promote locomotor recovery and axon regrowth in zebrafish SCI model possibly by regulating inflammatory response. ..
Al Ali H, Ding Y, Slepak T, Wu W, Sun Y, Martinez Y, et al
. The mTOR Substrate S6 Kinase 1 (S6K1) Is a Negative Regulator of Axon Regeneration and a Potential Drug Target for Central Nervous System Injury. J Neurosci. 2017;37:7079-7095 pubmed publisher
..We provide mechanistic evidence that S6K1's negative feedback to PI3K signaling is involved in axon growth inhibition, and show that phosphorylation of S6K1 is a more appropriate regeneration indicator than is S6 phosphorylation. ..
Wehner D, Tsarouchas T, Michael A, Haase C, Weidinger G, Reimer M, et al
. Wnt signaling controls pro-regenerative Collagen XII in functional spinal cord regeneration in zebrafish. Nat Commun. 2017;8:126 pubmed publisher
..Here, the authors show that Wnt/?-catenin signaling in fibroblast-like cells at a lesion activates axon re-growth via deposition of Collagen XII. ..