leukotriene b4


Summary: The major metabolite in neutrophil polymorphonuclear leukocytes. It stimulates polymorphonuclear cell function (degranulation, formation of oxygen-centered free radicals, arachidonic acid release, and metabolism). (From Dictionary of Prostaglandins and Related Compounds, 1990)

Top Publications

  1. Grespan R, Fukada S, Lemos H, Vieira S, Napimoga M, Teixeira M, et al. CXCR2-specific chemokines mediate leukotriene B4-dependent recruitment of neutrophils to inflamed joints in mice with antigen-induced arthritis. Arthritis Rheum. 2008;58:2030-40 pubmed publisher
    ..High levels of CXCL1, CXCL5, and leukotriene B4 (LTB4) were expressed in the joints of arthritic mice...
  2. Wang Z, Filgueiras L, Wang S, Serezani A, Peters Golden M, Jancar S, et al. Leukotriene B4 enhances the generation of proinflammatory microRNAs to promote MyD88-dependent macrophage activation. J Immunol. 2014;192:2349-56 pubmed publisher
    ..To our knowledge, our data unveil a heretofore unrecognized role for the GPCR BLT1 in controlling expression of microRNAs that regulate MyD88-dependent activation of macrophages. ..
  3. Xu S, Tang L, Mi Y, Jiang J, Zhu M, Chen B, et al. Clinical significance of leukotriene b4 and extracellular matrix metalloproteinase inducer in acute coronary syndrome. Clin Invest Med. 2013;36:E282-9 pubmed
    b>Leukotriene B4 (LTB4) and extracellular matrix metalloproteinase (EMMPRIN) have been suggested as modulators of atherosclerotic plaque instability...
  4. Di Gennaro A, Haeggstrom J. Targeting leukotriene B4 in inflammation. Expert Opin Ther Targets. 2014;18:79-93 pubmed publisher
  5. Secatto A, Rodrigues L, Serezani C, Ramos S, Dias Baruffi M, Faccioli L, et al. 5-Lipoxygenase deficiency impairs innate and adaptive immune responses during fungal infection. PLoS ONE. 2012;7:e31701 pubmed publisher
    ..Our results demonstrate that leukotrienes are required to control chronic fungal infection by amplifying both the innate and adaptive immune response during histoplasmosis. ..
  6. Wan M, Godson C, Guiry P, Agerberth B, Haeggstrom J. Leukotriene B4/antimicrobial peptide LL-37 proinflammatory circuits are mediated by BLT1 and FPR2/ALX and are counterregulated by lipoxin A4 and resolvin E1. FASEB J. 2011;25:1697-705 pubmed publisher
    ..This proinflammatory circuit might be inhibited by LXA(4) and RvE(1) acting at FPR2/ALX and BLT1, respectively, leading to dampened mediator release. ..
  7. Carraro S, Andreola B, Alinovi R, Corradi M, Freo L, Da Dalt L, et al. Exhaled leukotriene B4 in children with community acquired pneumonia. Pediatr Pulmonol. 2008;43:982-6 pubmed publisher
    The infiltrate in pneumonia is characterized by a large number of activated neutrophils, for which leukotriene B4 (LTB4) is a strong chemotactic agent...
  8. Xu S, Lu H, Lin J, Chen Z, Jiang D. Regulation of TNFalpha and IL1beta in rheumatoid arthritis synovial fibroblasts by leukotriene B4. Rheumatol Int. 2010;30:1183-9 pubmed publisher
    Arachidonic acid metabolites, such as leukotriene B4 (LTB4), are known to play an important role in pathogenesis of rheumatoid arthritis (RA)...
  9. Waki H, Hendy E, Hindmarch C, Gouraud S, Toward M, Kasparov S, et al. Excessive leukotriene B4 in nucleus tractus solitarii is prohypertensive in spontaneously hypertensive rats. Hypertension. 2013;61:194-201 pubmed publisher
    ..We found that the expression of several enzymes involved in arachidonic acid-leukotriene B4 (LTB4) production was altered in nucleus tractus solitarii (NTS) of spontaneously hypertensive rat (SHR)...

Scientific Experts

More Information


  1. van der Steen L, Tuk C, Bakema J, Kooij G, Reijerkerk A, Vidarsson G, et al. Immunoglobulin A: Fc(alpha)RI interactions induce neutrophil migration through release of leukotriene B4. Gastroenterology. 2009;137:2018-29.e1-3 pubmed publisher
    ..The responsible chemotactic factor was identified as leukotriene B4. Moreover, dimeric IgA (dIgA), which is produced in the lamina propria, but neither secretory IgA nor IgG, was ..
  2. Hutchinson J, Li Y, Arruda J, Baccei C, Bain G, Chapman C, et al. 5-lipoxygenase-activating protein inhibitors: development of 3-[3-tert-butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM103). J Med Chem. 2009;52:5803-15 pubmed publisher
    ..Compound 11j was selected for clinical development and has successfully completed phase 1 trials in healthy volunteers. ..
  3. Guerrero M, Aquino M, Bruno I, Riccio R, Terencio M, Paya M. Anti-inflammatory and analgesic activity of a novel inhibitor of microsomal prostaglandin E synthase-1 expression. Eur J Pharmacol. 2009;620:112-9 pubmed publisher
  4. Fourie A. Modulation of inflammatory disease by inhibitors of leukotriene A4 hydrolase. Curr Opin Investig Drugs. 2009;10:1173-82 pubmed
    ..A4 hydrolase (LTA4H) is a ubiquitously expressed enzyme that catalyzes the final step in the synthesis of leukotriene B4 (LTB4), a potent proinflammatory lipid mediator derived from arachidonic acid...
  5. Costa M, de Souza Martins R, de Souza M, Benjamim C, Piva B, Diaz B, et al. Leukotriene B4 mediates gammadelta T lymphocyte migration in response to diverse stimuli. J Leukoc Biol. 2010;87:323-32 pubmed publisher
    ..These data show that gammadelta T cell migration into the pleural cavity of mice during diverse inflammatory responses is dependent on LTB(4)/BLT1. ..
  6. Serezani C, Lewis C, Jancar S, Peters Golden M. Leukotriene B4 amplifies NF-?B activation in mouse macrophages by reducing SOCS1 inhibition of MyD88 expression. J Clin Invest. 2011;121:671-82 pubmed publisher
    Activation of NF-?B and 5-lipoxygenase-mediated (5-LO-mediated) biosynthesis of the lipid mediator leukotriene B4 (LTB4) are pivotal components of host defense and inflammatory responses...
  7. Medeiros A, Sa Nunes A, Turato W, Secatto A, Frantz F, Sorgi C, et al. Leukotrienes are potent adjuvant during fungal infection: effects on memory T cells. J Immunol. 2008;181:8544-51 pubmed
    ..These data establish an important immunomodulatory role of LTs, in both the primary and secondary immune responses to histoplasmosis. ..
  8. Ohnishi H, Miyahara N, Gelfand E. The role of leukotriene B(4) in allergic diseases. Allergol Int. 2008;57:291-8 pubmed publisher
    ..Inhibition of this pathway has potential therapeutic benefit in various allergic diseases that have involvement of corticosteroid-insensitivity...
  9. Narala V, Adapala R, Suresh M, Brock T, Peters Golden M, Reddy R. Leukotriene B4 is a physiologically relevant endogenous peroxisome proliferator-activated receptor-alpha agonist. J Biol Chem. 2010;285:22067-74 pubmed publisher
  10. Hikiji H, Ishii S, Yokomizo T, Takato T, Shimizu T. A distinctive role of the leukotriene B4 receptor BLT1 in osteoclastic activity during bone loss. Proc Natl Acad Sci U S A. 2009;106:21294-9 pubmed publisher
    ..Inhibition of BLT1 functions may represent a strategy for preventing bone resorption diseases. ..
  11. Monteiro A, Pinheiro C, Luna Gomes T, Alves L, Maya Monteiro C, Porto B, et al. Leukotriene B4 mediates neutrophil migration induced by heme. J Immunol. 2011;186:6562-7 pubmed publisher
  12. Stanke Labesque F, Pepin J, de Jouvencel T, Arnaud C, Baguet J, Petri M, et al. Leukotriene B4 pathway activation and atherosclerosis in obstructive sleep apnea. J Lipid Res. 2012;53:1944-51 pubmed publisher
    ..In conclusion, upregulation of FLAP in PMNs in response to IH may participate in early vascular remodeling in OSA patients, suggesting FLAP as a potential therapeutic target for the cardiovascular morbidity associated with OSA. ..
  13. Nicolete R, Rius C, Piqueras L, Jose P, Sorgi C, Soares E, et al. Leukotriene B4-loaded microspheres: a new therapeutic strategy to modulate cell activation. BMC Immunol. 2008;9:36 pubmed publisher
    b>Leukotriene B4 (LTB4) is a potent inflammatory mediator that also stimulates the immune response. In addition, it promotes polymorphonuclear leukocyte phagocytosis, chemotaxis, chemokinesis and modulates cytokines release...
  14. Lee S, Serezani C, Medeiros A, Ballinger M, Peters Golden M. Crosstalk between prostaglandin E2 and leukotriene B4 regulates phagocytosis in alveolar macrophages via combinatorial effects on cyclic AMP. J Immunol. 2009;182:530-7 pubmed
  15. Kim E, Seo J, Cho K, Kim J. Ras-induced invasion and metastasis are regulated by a leukotriene B4 receptor BLT2-linked pathway. Oncogene. 2010;29:1167-78 pubmed publisher
    ..Together, our results reveal the previously unsuspected function of BLT2-linked cascade in driving oncogenic Ras-induced metastasis and would provide a valuable insight into invasion and metastasis. ..
  16. Yano T, Fujioka D, Saito Y, Kobayashi T, Nakamura T, Obata J, et al. Group V secretory phospholipase A2 plays a pathogenic role in myocardial ischaemia-reperfusion injury. Cardiovasc Res. 2011;90:335-43 pubmed publisher
    ..sPLA(2)-V plays an important role in the pathogenesis of myocardial I/R injury partly in concert with the activation of cPLA(2). ..
  17. Bhavsar P, Levy B, Hew M, Pfeffer M, Kazani S, Israel E, et al. Corticosteroid suppression of lipoxin A4 and leukotriene B4 from alveolar macrophages in severe asthma. Respir Res. 2010;11:71 pubmed publisher
    ..We measured leukotriene B4 (LTB4), and lipoxin A4 (LXA4) production by alveolar macrophages (AMs) and studied the impact of ..
  18. Okamoto F, Saeki K, Sumimoto H, Yamasaki S, Yokomizo T. Leukotriene B4 augments and restores Fc gammaRs-dependent phagocytosis in macrophages. J Biol Chem. 2010;285:41113-21 pubmed publisher
    ..Surprisingly, we found that LTB(4)-BLT1 signaling restores phagocytosis in the absence of Fc?Rs signaling. These data indicate that LTB(4)-BLT1 signaling plays a pivotal role in macrophage phagocytosis and innate immunity. ..
  19. Ko F, Leung T, Wong G, Ngai J, To K, Ng S, et al. Measurement of tumor necrosis factor-alpha, leukotriene B4, and interleukin 8 in the exhaled breath condensate in patients with acute exacerbations of chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2009;4:79-86 pubmed
    ..Concentrations of tumor necrosis factor-alpha (TNF-alpha), leukotriene B4 (LTB4), and interleukin-8 (IL-8) were measured by enzyme-linked immunosorbent assay...
  20. Campos M, Serezani C, Peters Golden M, Jancar S. Differential kinase requirement for enhancement of Fc gammaR-mediated phagocytosis in alveolar macrophages by leukotriene B4 vs. D4. Mol Immunol. 2009;46:1204-11 pubmed publisher
    ..Taken together, our data show that the capacities of LTB(4) and LTD(4) to enhance Fc gammaR-mediated phagocytosis reflect their differential activation of specific kinase programs...
  21. Mancuso P, Lewis C, Serezani C, Goel D, Peters Golden M. Intrapulmonary administration of leukotriene B4 enhances pulmonary host defense against pneumococcal pneumonia. Infect Immun. 2010;78:2264-71 pubmed publisher
    ..The results of the current study in an animal model serve as a proof of concept for the potential utility of treatment with aerosolized LTB(4) as an immunostimulatory strategy in patients with bacterial pneumonia...
  22. Sorgi C, Secatto A, Fontanari C, Turato W, Belanger C, de Medeiros A, et al. Histoplasma capsulatum cell wall {beta}-glucan induces lipid body formation through CD18, TLR2, and dectin-1 receptors: correlation with leukotriene B4 generation and role in HIV-1 infection. J Immunol. 2009;182:4025-35 pubmed publisher
    ..These results demonstrate that Hc induces LB formation, an event correlated with eicosanoid production, and suggest a role for these lipid-enriched organelles in host defense during fungal infection. ..
  23. Loke W, Lam K, Chong W, Chew S, Quek A, Lim E, et al. Products of 5-lipoxygenase and myeloperoxidase activities are increased in young male cigarette smokers. Free Radic Res. 2012;46:1230-7 pubmed publisher
    ..These results suggest that cigarette smoking aggravates neutrophil-mediated inflammation by modulating the activities of myeloperoxidase and 5-lipoxygenase pathways. ..
  24. Auner B, Geiger E, Henrich D, Lehnert M, Marzi I, Relja B. Circulating leukotriene B4 identifies respiratory complications after trauma. Mediators Inflamm. 2012;2012:536156 pubmed publisher
    b>Leukotriene B4 (LTB4), a proinflammatory lipid mediator correlates well with the acute phase of Acute Respiratory Distress Syndrome (ARDS)...
  25. Chouinard F, Lefebvre J, Navarro P, Bouchard L, Ferland C, Lalancette Hébert M, et al. The endocannabinoid 2-arachidonoyl-glycerol activates human neutrophils: critical role of its hydrolysis and de novo leukotriene B4 biosynthesis. J Immunol. 2011;186:3188-96 pubmed publisher
    ..In conclusion, we demonstrated that 2-AG potently activates human neutrophils. This is the consequence of 2-AG hydrolysis, de novo LTB(4) biosynthesis, and an autocrine activation loop involving LTB(4) receptor 1. ..
  26. Nicolete R, Secatto A, Pereira P, Soares E, Faccioli L. Leukotriene B4-loaded microspheres as a new approach to enhance antimicrobial responses in Histoplasma capsulatum-infected mice. Int J Antimicrob Agents. 2009;34:365-9 pubmed publisher
    ..Our study provides evidence that the proposed biodegradable microparticulate system, which can release LTB(4) to the lungs, can be employed as therapy, enhancing the antimicrobial activity of host cells during histoplasmosis. ..
  27. Tobin D, Roca F, Oh S, McFarland R, Vickery T, Ray J, et al. Host genotype-specific therapies can optimize the inflammatory response to mycobacterial infections. Cell. 2012;148:434-46 pubmed publisher
    ..Together, our findings suggest that host-directed therapies tailored to patient LTA4H genotypes may counter detrimental effects of either extreme of inflammation. ..
  28. Leite A, Cunha F, Dal Secco D, Fukada S, Girão V, Rocha F. Effects of nitric oxide on neutrophil influx depends on the tissue: role of leukotriene B4 and adhesion molecules. Br J Pharmacol. 2009;156:818-25 pubmed publisher
    ..We investigated the effect of nitric oxide synthase (NOS) inhibition on polymorphonuclear cell (PMN) influx in zymosan or lipopolysaccharide (LPS)-induced arthritis and peritonitis...
  29. Serezani C, Kane S, Collins L, Morato Marques M, Osterholzer J, Peters Golden M. Macrophage dectin-1 expression is controlled by leukotriene B4 via a GM-CSF/PU.1 axis. J Immunol. 2012;189:906-15 pubmed publisher
    ..Our results identify LTB(4)-BLT1 signaling as an unrecognized controller of dectin-1 transcription via GM-CSF and PU.1 that is required for fungi-protective host responses. ..
  30. Houard X, Ollivier V, Louedec L, Michel J, Bäck M. Differential inflammatory activity across human abdominal aortic aneurysms reveals neutrophil-derived leukotriene B4 as a major chemotactic factor released from the intraluminal thrombus. FASEB J. 2009;23:1376-83 pubmed publisher
  31. Chaves M, Marques da Silva C, Monteiro A, Canetti C, Coutinho Silva R. Leukotriene B4 modulates P2X7 receptor-mediated Leishmania amazonensis elimination in murine macrophages. J Immunol. 2014;192:4765-73 pubmed publisher
    ..It has been reported that leukotriene B4 (LTB4) reduces the parasitic load of infected macrophages...
  32. Carlos D, Machado E, De Paula L, Sa Nunes A, Sorgi C, Jamur M, et al. Evidence for eosinophil recruitment, leukotriene B4 production and mast cell hyperplasia following Toxocara canis infection in rats. Braz J Med Biol Res. 2011;44:319-26 pubmed
    ..canis infection in rats. Our data also demonstrate a tight association between larval migratory stages and intestinal and pulmonary mast cell hyperplasia in the toxocariasis model...
  33. Park S, Heo D, Sung M. The shunting of arachidonic acid metabolism to 5-lipoxygenase and cytochrome p450 epoxygenase antagonizes the anti-cancer effect of cyclooxygenase-2 inhibition in head and neck cancer cells. Cell Oncol (Dordr). 2012;35:1-8 pubmed publisher
    ..In addition, combined therapies should be chosen based on the expression of members of other AA metabolism pathways. ..
  34. Fredman G, Oh S, Ayilavarapu S, Hasturk H, Serhan C, Van Dyke T. Impaired phagocytosis in localized aggressive periodontitis: rescue by Resolvin E1. PLoS ONE. 2011;6:e24422 pubmed publisher
    ..These abnormalities suggest compromised resolution pathways, which may contribute to persistent inflammation resulting in establishment of a chronic inflammatory lesion and periodontal disease progression. ..
  35. Eun J, Moore E, Banerjee A, Kelher M, Khan S, Elzi D, et al. Leukotriene b4 and its metabolites prime the neutrophil oxidase and induce proinflammatory activation of human pulmonary microvascular endothelial cells. Shock. 2011;35:240-4 pubmed publisher
    Leukotrienes are proinflammatory lipid mediators, derived from arachidonic acid via 5-lipoxygenase (5-LO). Leukotriene B4 (LTB4) is an effective polymorphonuclear neutrophil (PMN) chemoattractant, as well as being a major product of PMN ..
  36. Bertin J, Barat C, Bélanger D, Tremblay M. Leukotrienes inhibit early stages of HIV-1 infection in monocyte-derived microglia-like cells. J Neuroinflammation. 2012;9:55 pubmed publisher
    ..b>Leukotriene B4 (LTB4) and cysteinyl-leukotrienes such as LTC4 are some of the proinflammatory molecules produced in infected ..
  37. Catoire L, Damian M, Giusti F, Martin A, van Heijenoort C, Popot J, et al. Structure of a GPCR ligand in its receptor-bound state: leukotriene B4 adopts a highly constrained conformation when associated to human BLT2. J Am Chem Soc. 2010;132:9049-57 pubmed publisher
    ..and folded to its native state using amphipols, we have solved, by (1)H NMR, the structure of receptor-bound leukotriene B4 (LTB4)...
  38. Carneiro E, Xavier R, De Castro M, do Nascimento C, Silveira V. Electroacupuncture promotes a decrease in inflammatory response associated with Th1/Th2 cytokines, nitric oxide and leukotriene B4 modulation in experimental asthma. Cytokine. 2010;50:335-40 pubmed publisher
    ..Th2 cytokines, leukotriene B4 (LTB4) and nitric oxide (NO) are involved in the asthma inflammatory process...
  39. Moraes J, Assreuy J, Canetti C, Barja Fidalgo C. Leukotriene B4 mediates vascular smooth muscle cell migration through ?v?3 integrin transactivation. Atherosclerosis. 2010;212:406-13 pubmed publisher
    ..Released by leukocytes, leukotriene B4 (LTB4) induces reactive oxygen species production and SMC chemotaxis...
  40. Bachi A, Kim F, Nonogaki S, Carneiro C, Lopes J, Jasiulionis M, et al. Leukotriene B4 creates a favorable microenvironment for murine melanoma growth. Mol Cancer Res. 2009;7:1417-24 pubmed publisher
    ..b>Leukotriene B4 (LTB4), the main product of the 5-LOX pathway, was able to induce growth of subtumorigenic inocula of melanoma ..
  41. Wang Y, Zhao J, Kalsotra A, Turman C, Grill R, Dash P, et al. CYP4Fs expression in rat brain correlates with changes in LTB4 levels after traumatic brain injury. J Neurotrauma. 2008;25:1187-94 pubmed publisher
    ..These changes in CYP4F levels inversely correlate with levels of leukotriene B4 (LTB4) levels in the brain following injury at the same time points...
  42. Farias S, Frey L, Murphy R, Heidenreich K. Injury-related production of cysteinyl leukotrienes contributes to brain damage following experimental traumatic brain injury. J Neurotrauma. 2009;26:1977-86 pubmed publisher
  43. Tian W, Jiang X, Tamosiuniene R, Sung Y, Qian J, Dhillon G, et al. Blocking macrophage leukotriene b4 prevents endothelial injury and reverses pulmonary hypertension. Sci Transl Med. 2013;5:200ra117 pubmed publisher
    ..accumulated macrophages expressed high levels of leukotriene A4 hydrolase (LTA4H), the biosynthetic enzyme for leukotriene B4 (LTB4)...
  44. Corhay J, Henket M, Nguyen D, Duysinx B, Sele J, Louis R. Leukotriene B4 contributes to exhaled breath condensate and sputum neutrophil chemotaxis in COPD. Chest. 2009;136:1047-1054 pubmed publisher
    ..5 x 10(-4) mol/L) reduced by 44.6% and by 44.4%, respectively, the chemotactic activity contained in the EBC and sputum samples. EBC and IS from COPD patients have a raised NCA to which LTB(4) contributes. ..
  45. Kim G, Lee J, Cho S, Seo J, Kim J. Role of the low-affinity leukotriene B4 receptor BLT2 in VEGF-induced angiogenesis. Arterioscler Thromb Vasc Biol. 2009;29:915-20 pubmed publisher
    ..The activation of BLT2 itself by either 12(S)-HETE or LTB(4) evoked significant angiogenic phenotypes, both in vitro and in vivo. Our findings indicate that BLT2 plays an essential role in mediating VEGF-induced angiogenesis. ..
  46. Kimoto Nira H, Suzuki C, Kobayashi M, Sasaki K, Mizumachi K. Inhibition of leukotriene B4 production in murine macrophages by lactic acid bacteria. Int J Food Microbiol. 2009;129:321-4 pubmed publisher
    ..This study also highlights the potential of the strain Bc-10 as a treatment option for the regulation of LTB(4) production in vivo. ..
  47. Widegren H, Andersson M, Borgeat P, Flamand L, Johnston S, Greiff L. LTB4 increases nasal neutrophil activity and conditions neutrophils to exert antiviral effects. Respir Med. 2011;105:997-1006 pubmed publisher
    b>Leukotriene B4 (LTB4) recruits and activates neutrophils. Accordingly, this leukotriene is involved in innate defense actions...
  48. Matsunaga Y, Fukuyama S, Okuno T, Sasaki F, Matsunobu T, Asai Y, et al. Leukotriene B4 receptor BLT2 negatively regulates allergic airway eosinophilia. FASEB J. 2013;27:3306-14 pubmed publisher
    b>Leukotriene B4 (LTB4) has been implicated in the pathogenesis of allergic diseases. BLT2, a low-affinity LTB4 receptor, is activated by LTB4 and 12(S)-hydroxyheptadeca-5Z,8E,10E-trienoic acid (12-HHT)...
  49. Kiss A, Filipek A, Czerwińska M, Naruszewicz M. Oenothera paradoxa defatted seeds extract and its bioactive component penta-O-galloyl-?-D-glucose decreased production of reactive oxygen species and inhibited release of leukotriene B4, interleukin-8, elastase, and myeloperoxidase in human neutrophi. J Agric Food Chem. 2010;58:9960-6 pubmed publisher
    ..by determining the release from activated neutrophils of elastase, myeloperoxidase, interleukin-8 (IL-8), and leukotriene B4 (LTB4), which are considered relevant for the pathogenesis of cardiovascular diseases. The extract of O...
  50. Kogut M, He H, Genovese K. Bacterial toll-like receptor agonists induce sequential NF-?B-mediated leukotriene B4 and prostaglandin E2 production in chicken heterophils. Vet Immunol Immunopathol. 2012;145:159-70 pubmed publisher
    ..Since FLG, lipoproteins, and bacterial CpG DNA are abundant during bacterial infections, these data support their role in the inflammatory response mediated by avian heterophils. ..
  51. Sánchez Galán E, Gómez Hernández A, Vidal C, Martin Ventura J, Blanco Colio L, Munoz Garcia B, et al. Leukotriene B4 enhances the activity of nuclear factor-kappaB pathway through BLT1 and BLT2 receptors in atherosclerosis. Cardiovasc Res. 2009;81:216-25 pubmed publisher
    b>Leukotriene B4 (LTB4) is a powerful chemoattractant and pro-inflammatory mediator in several inflammatory diseases, including atherosclerosis. It acts through its two membrane receptors, BLT1 and BLT2...
  52. Montuschi P. LC/MS/MS analysis of leukotriene B4 and other eicosanoids in exhaled breath condensate for assessing lung inflammation. J Chromatogr B Analyt Technol Biomed Life Sci. 2009;877:1272-80 pubmed publisher