Summary: An octapeptide analog of angiotensin II (bovine) with amino acids 1 and 8 replaced with sarcosine and alanine, respectively. It is a highly specific competitive inhibitor of angiotensin II that is used in the diagnosis of HYPERTENSION.

Top Publications

  1. Olsson M, Annerbrink K, Hedner J, Eriksson E. Intracerebroventricular administration of the angiotensin II receptor antagonist saralasin reduces respiratory rate and tidal volume variability in freely moving Wistar rats. Psychoneuroendocrinology. 2004;29:107-12 pubmed
    ..anxiety, we have studied the effect of intracerebroventricular administration of an ANG II receptor antagonist, saralasin, on respiratory variability in unrestrained, freely moving male Wistar rats...
  2. Siragy H, Howell N, Peach M, Carey R. Combined intrarenal renin-angiotensin blockade alters renal function and this is reversed by angiotensin II. J Hypertens Suppl. 1989;7:S174-5 pubmed
    ..of the renin inhibitor ACRIP to inhibit renin, teprotide to inhibit the angiotensin converting enzyme (ACE) and saralasin to block Ang II receptors...
  3. Tanaka J, Miyakubo H, Nomura M. Estrogen decreases the responsiveness of subfornical organ neurons to angiotensinergic neural inputs from the lateral hypothalamic area in the female rat. Exp Neurol. 2001;171:301-7 pubmed either ANG II or LHA stimulation was blocked by microiontophoretic application of the ANG II antagonist saralasin (Sar), suggesting that the excitatory response to LHA stimulation may be mediated by angiotensinergic LHA ..
  4. Grant T, McGrath J. Interactions between angiotensin II and alpha-adrenoceptor agonists mediating pressor responses in the pithed rat. Br J Pharmacol. 1988;95:1229-40 pubmed
    ..4. The AII-receptor antagonist, saralasin (4 micrograms kg-1 min-1) attenuated alpha 1- and alpha 2-adrenoceptor-mediated pressor responses in a manner ..
  5. Kim J, Jiang Y, Cohen I, Lin R, Mathias R. Pressure-overload-induced angiotensin-mediated early remodeling in mouse heart. PLoS ONE. 2017;12:e0176713 pubmed publisher
    ..Incubation of these myocytes with the angiotensin II type 1 receptor inhibitor saralasin for 2 hours restored Ito,fast and IK,slow to control levels. The number of Ito...
  6. Aydin C, Yalcin M. Peripheral mechanisms involved in the pressor and bradycardic effects of centrally administered arachidonic acid. Prostaglandins Leukot Essent Fatty Acids. 2008;78:361-8 pubmed publisher
    ..O-Me-Tyr2-Arg8]-vasopressin (10 microg/kg), a vasopressin V1 receptor antagonist, or saralasin (250 microg/kg), an angiotensin II receptor antagonist, partially blocked the pressor response to arachidonic ..
  7. Chan P, Wong K, Liu I, Tzeng T, Yang T, Cheng J. Antihyperglycemic action of angiotensin II receptor antagonist, valsartan, in streptozotocin-induced diabetic rats. J Hypertens. 2003;21:761-9 pubmed
    ..Otherwise, infusion of saralasin (10 microg/kg per min) into STZ-diabetic rats produced a plasma glucose-lowering activity similar to that by ..
  8. Deliu E, Tica A, Motoc D, Brailoiu G, Brailoiu E. Intracellular angiotensin II activates rat myometrium. Am J Physiol Cell Physiol. 2011;301:C559-65 pubmed publisher
  9. Calaghan S, White E. Contribution of angiotensin II, endothelin 1 and the endothelium to the slow inotropic response to stretch in ferret papillary muscle. Pflugers Arch. 2001;441:514-20 pubmed
    ..Angiotensin antagonists losartan and saralasin did not affect the magnitude of the slow response in ferret papillary muscle...

More Information


  1. Wang H, Lin L, Fu W, Yu H, Yu N, Tan L, et al. Preventive effects of the novel antimicrobial peptide Nal-P-113 in a rat Periodontitis model by limiting the growth of Porphyromonas gingivalis and modulating IL-1? and TNF-? production. BMC Complement Altern Med. 2017;17:426 pubmed publisher
    ..The use of Nal-P-113 in vivo might serve as a beneficial preventive or therapeutic approach for periodontitis. ..
  2. Wang L, Ma X, Xiang L, Lu M, Yan C, Zhao S, et al. The characterization and prognostic significance of right ventricular glucose metabolism in non-ischemic dilated cardiomyopathy. J Nucl Cardiol. 2016;23:758-67 pubmed publisher
    ..01 showed no significance (HR 2.611; 95% CI 0.797-8.558; P = .113). Increased RV FDG uptake was associated with RV dysfunction and may be a prognostic predictor of all-cause mortality or heart transplantation in patients with DCM. ..
  3. Fathi M, Valiee S, Mahmoodi P. Effect of changing the duration of keeping sandbag over catheter insertion site on the coronary angiography acute complications: A controlled clinical trial. J Vasc Nurs. 2017;35:193-200 pubmed publisher
  4. Kuji N, Sueoka K, Miyazaki T, Tanaka M, Oda T, Kobayashi T, et al. Involvement of angiotensin II in the process of gonadotropin-induced ovulation in rabbits. Biol Reprod. 1996;55:984-91 pubmed
    ..Ang II produced locally by gonadotropin exposure may be a part of a novel intraovarian paracrine or autocrine control mechanism that operates via the AT2 receptor in the ovary. ..
  5. Katikireddi S, Der G, Roberts C, Haw S. Has Childhood Smoking Reduced Following Smoke-Free Public Places Legislation? A Segmented Regression Analysis of Cross-Sectional UK School-Based Surveys. Nicotine Tob Res. 2016;18:1670-4 pubmed publisher
    ..If this association is causal, comprehensive smoke-free legislation could help prevent future generations from taking up smoking. ..
  6. Tanaka J, Hayashi Y, Sakamaki K, Okumura T, Nomura M. Activation of the subfornical organ enhances extracellular noradrenaline concentrations in the hypothalamic paraventricular nucleus in the rat. Brain Res Bull. 2001;54:421-5 pubmed
    ..PVN, and the increase was significantly prevented by pretreatment with the angiotensin II (ANG II) antagonist saralasin (Sar, 5 microg), into the third ventricle (3V)...
  7. Koramaz I, El Kilic H, Gokalp F, Bitargil M, Bektaş N, Engin E, et al. Ablation of the great saphenous vein with nontumescent n-butyl cyanoacrylate versus endovenous laser therapy. J Vasc Surg Venous Lymphat Disord. 2017;5:210-215 pubmed publisher
    ..Further large-scale studies with long-term outcomes are required to identify the optimal treatment modalities for patients with saphenous vein insufficiency. ..
  8. Yoshimura Y, Karube M, Aoki H, Oda T, Koyama N, Nagai A, et al. Angiotensin II induces ovulation and oocyte maturation in rabbit ovaries via the AT2 receptor subtype. Endocrinology. 1996;137:1204-11 pubmed
    ..b>Saralasin, a peptide analog of Ang II, inhibited the specific binding of [125I] iodo-[Sar1, Ile8] Ang II to rabbit ovarian ..
  9. Bensoussan M, Mitchell T, Reilly T, Timmermans P, Verroust P, Ronco P. Immunological reactivity of angiotensin II receptor antagonists: possible implications for receptor binding sites. Eur J Pharmacol. 1993;247:169-75 pubmed
    ..abstract truncated at 250 words) ..
  10. Frenkel L, Suárez L, Maldonado H, Delorenzi A. Angiotensin modulates long-term memory expression but not long-term memory storage in the crab Chasmagnathus. Neurobiol Learn Mem. 2010;94:509-20 pubmed publisher
    ..First, the well-known retrograde amnesic effect of the angiotensin II antagonist saralasin is not due to interference on memory storage, but to modulation of memory expression...
  11. Zhang J, Wu J, Gu C, Noble N, Border W, Huang Y. Receptor-mediated nonproteolytic activation of prorenin and induction of TGF-?1 and PAI-1 expression in renal mesangial cells. Am J Physiol Renal Physiol. 2012;303:F11-20 pubmed publisher
    ..mRNA expression, and these effects were blocked by (p)RR siRNA, but not by the ANG II receptor antagonist, saralasin. When angiotensinogen was also added to cultured MCs with inactive native or mutant prorenin, PAI-1 and ..
  12. Wang H, Cheng J, Yu H, Lin L, Chih Y, Pan Y. Efficacy of a novel antimicrobial peptide against periodontal pathogens in both planktonic and polymicrobial biofilm states. Acta Biomater. 2015;25:150-61 pubmed publisher
    ..This study provides a proof of concept in applying antimicrobial peptides in the clinical perspective. ..
  13. Ding H, Guo Y, Xu M, Li H, Fu Z. Effect of angiotensin II receptor blocker on glucose-induced mRNA expressions of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in rat mesangial cells. Chin Med J (Engl). 2007;120:1886-9 pubmed
    ..and divided into 5 groups: normal glucose (group NG), high glucose (group HG), group NG + AII, NG + AII + saralasin (group NG + AII + S, saralasin is the AII receptor blocker) and HG + saralasin (group HG + S)...
  14. Van Hazel G, Heinemann V, Sharma N, Findlay M, Ricke J, Peeters M, et al. SIRFLOX: Randomized Phase III Trial Comparing First-Line mFOLFOX6 (Plus or Minus Bevacizumab) Versus mFOLFOX6 (Plus or Minus Bevacizumab) Plus Selective Internal Radiation Therapy in Patients With Metastatic Colorectal Cancer. J Clin Oncol. 2016;34:1723-31 pubmed publisher
    ..The safety profile was as expected and was consistent with previous studies. ..
  15. Ganong W. Circumventricular organs: definition and role in the regulation of endocrine and autonomic function. Clin Exp Pharmacol Physiol. 2000;27:422-7 pubmed
    ..Thyrotropin-releasing hormone secretion is regulated by thyroid hormones transported across cerebral capillaries. However, CVO may be involved in the negative feedback control of growth hormone and prolactin secretion. ..
  16. Ramracheya R, Muller D, Wu Y, Whitehouse B, Huang G, Amiel S, et al. Direct regulation of insulin secretion by angiotensin II in human islets of Langerhans. Diabetologia. 2006;49:321-31 pubmed
    ..Locally produced angiotensin II may be important in regulating a coordinated insulin secretory response from beta cells. ..
  17. Castillo Hernandez J, Torres Tirado D, Barajas Espinosa A, Chi Ahumada E, Ramiro Diaz J, Ceballos G, et al. Two dissimilar AT(1) agonists distinctively activate AT(1) receptors located on the luminal membrane of coronary endothelium. Vascul Pharmacol. 2009;51:314-22 pubmed publisher
  18. Morita H, Kimura J, Endoh M. Angiotensin II activation of a chloride current in rabbit cardiac myocytes. J Physiol. 1995;483 ( Pt 1):119-30 pubmed
    ..The effect was concentration dependent (10(-9)-10(-6) M) and was inhibited by saralasin, an antagonist of Ang II receptors. 4...
  19. Breno M, Porto C, Picarelli Z. Angiotensin receptor in the heart of Bothrops jararaca snake. Eur J Pharmacol. 2001;417:27-35 pubmed
    ..jararaca snake pharmacologically distinct from angiotensin AT1 and AT2 receptors. It seems to belong to a new class of angiotensin receptors, like some other atypical angiotensin AT receptors that have already been described. ..
  20. Tsang S, Ip S, Wong T, Che C, Leung P. Differential effects of saralasin and ramiprilat, the inhibitors of renin-angiotensin system, on cerulein-induced acute pancreatitis. Regul Pept. 2003;111:47-53 pubmed
    ..of cerulein-induced acute pancreatitis, results from the present study showed that an intravenous injection of saralasin, an antagonist for angiotensin II receptors, at a dose of 40 microg/kg 30 min before the induction of acute ..
  21. Wang M, Fok A, Huang M, Wong N. Interaction between endothelin and angiotensin II in the up-regulation of vasopressin messenger RNA in the inner medullary collecting duct of the rat. Metabolism. 2007;56:1372-6 pubmed
    ..In the second set of experiments, rat IMCD tissue was incubated with ET-1 with ANG receptor antagonist saralasin. Tissue samples were then analyzed by means of quantitative reverse transcriptase polymerase chain reaction and ..
  22. Lin G, Chen H, Xue Y, Yeh Y, Chen C, Liu M, et al. The Antimicrobial Peptides P-113Du and P-113Tri Function against Candida albicans. Antimicrob Agents Chemother. 2016;60:6369-73 pubmed publisher
    ..These results suggest that P-113Du and P-113Tri are promising candidates for development as novel antifungal agents. ..
  23. Jennings D. Cardiorespiratory effects of prolonged angiotensin II block in resting conscious dogs. Can J Physiol Pharmacol. 2001;79:825-30 pubmed
    Intravenous (iv) infusion of the angiotensin II (ANG II) receptor blocker saralasin in resting conscious dogs during physiological pertubations, such as hypotension and prolonged hypoxia, indicates the presence of an ANG II drive to ..
  24. Tanaka J, Kariya K, Miyakubo H, Sakamaki K, Nomura M. Attenuated drinking response induced by angiotensinergic activation of subfornical organ projections to the paraventricular nucleus in estrogen-treated rats. Neurosci Lett. 2002;324:242-6 pubmed
    ..In both groups, previous injections of either saralasin, an ANG II antagonist, or phentolamine, an alpha-adrenoceptor antagonist, bilaterally into the PVN resulted in ..
  25. Poli E, Casoli C, Spaggiari I, Starcich R, Bertaccini G. Contractile effect of endothelin-2 on the isolated human saphenous vein. Arch Int Pharmacodyn Ther. 1991;313:108-19 pubmed
    ..The activity of endothelin-2 was not modified by phentolamine, saralasin and indomethacin, thus excluding a direct or indirect activation of alpha-adrenoceptors and angiotensin ..
  26. Abassi Z, Klein H, Golomb E, Keiser H. Regulation of the urinary excretion of endothelin in the rat. Am J Hypertens. 1993;6:453-7 pubmed
    ..Infusions of A-II with its nonspecific antagonist, saralasin, resulted in a further increase in UETV to 647 +/- 126 and 782 +/- 117 fg/min (P < .002), respectively...
  27. Ferrer M, Alonso M, Salaices M, Marin J, Balfagon G. Angiotensin II increases neurogenic nitric oxide metabolism in mesenteric arteries from hypertensive rats. Life Sci. 2001;68:1169-79 pubmed
    ..These results suggest that EFS of SHR mesenteric arteries releases neurogenic NO, the metabolism of which is increased in the presence of AII by the generation of superoxide anions. ..
  28. Fujisawa S, Tanaka J, Nomura M. Estrogen attenuates the drinking response induced by activation of angiotensinergic pathways from the lateral hypothalamic area to the subfornical organ in female rats. Behav Brain Res. 2001;122:33-41 pubmed
    ..In both groups, previous injections of the ANG II antagonist saralasin (Sar, 10(-10) M, 0...
  29. Bank N, Aynedjian H. Role of thromboxane in impaired renal vasodilatation response to acetylcholine in hypercholesterolemic rats. J Clin Invest. 1992;89:1636-42 pubmed
    ..This may account in large measure for the blunted vasodilatation to acetylcholine. ..
  30. Petrescu G, Costuleanu M, Slatineanu S, Costuleanu N, Foia L, Costuleanu A. Contractile effects of angiotensin peptides in rat aorta are differentially dependent on tyrosine kinase activity. J Renin Angiotensin Aldosterone Syst. 2001;2:180-7 pubmed
    ..An elevation of intracellular calcium via tyrosine kinase-mediated processes may mediate the actions of G-protein coupled receptor agonists in smooth muscle, including angiotensin peptides. ..
  31. Robberecht W, Andries M, Denef C. Stimulation of prolactin secretion from rat pituitary by luteinizing hormone-releasing hormone: evidence against mediation by angiotensin II acting through a (Sar1-Ala8)-angiotensin II-sensitive receptor. Neuroendocrinology. 1992;56:185-94 pubmed
    ..The involvement of AII acting on a non-(Sar1,Ala8)AII-sensitive receptor cannot be excluded and warrants further investigation. ..
  32. O Connor M, Jennings D. Respiratory and metabolic effects of decreased osmolality in conscious rats. Can J Physiol Pharmacol. 2001;79:768-78 pubmed
    ..after oral gavage were obtained with and without water loading and with and without ANG II receptor block (saralasin, 1.3 microg x kg(-1) x min(-1) iv). At 15 min after water loading by oral gavage, ventilation (V, 1.14+/-0...
  33. Frenkel L, Maldonado H, Delorenzi A. Memory strengthening by a real-life episode during reconsolidation: an outcome of water deprivation via brain angiotensin II. Eur J Neurosci. 2005;22:1757-66 pubmed
    ..Reconsolidation improvement would lead to memory re-evaluation, not by altering memory content but by modifying the behaviour as an outcome of changing the hierarchy of the memories that control it. ..
  34. Moura A, Worcel M. [Ex vivo and in vitro effects of trandolapril on the efflux of 22Na from the caudal artery of the SHR rat. Inhibition of vascular angiotensin II production]. Arch Mal Coeur Vaiss. 1988;81 Spec No:175-7 pubmed
    ..084 +/- 0.006 min-1 (n = 6) p less than 0.05). The effects were dose-dependent. Enalapril diacid (MK 422) also dose-dependently decreased 22Na effluxes but it was approximately 10 fold less active.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  35. Emori T, Hirata Y, Ohta K, Shichiri M, Marumo F. Secretory mechanism of immunoreactive endothelin in cultured bovine endothelial cells. Biochem Biophys Res Commun. 1989;160:93-100 pubmed
    ..These data suggest that AVP and ANG II, like thrombin, stimulate ET secretion from EC by a mechanism possibly involving receptor-mediated mobilization of intracellular Ca2+ and activation of PKC. ..
  36. Langille B, Bendeck M. Arterial responses to compromised blood flow. Toxicol Pathol. 1990;18:618-22 pubmed
    ..All of these assessments yielded negative results. It appears, therefore, that a novel vasoactive substance initiates the adaptive response of arteries to reduced blood flow. ..
  37. Jones T, Brown B, Dobson P. Evidence that angiotensin II is a paracrine agent mediating gonadotrophin-releasing hormone-stimulated inositol phosphate production and prolactin secretion in the rat. J Endocrinol. 1988;116:367-71 pubmed
    ..b>Saralasin [( Sar1, Ala8]-angiotensin II; a competitive antagonist of angiotensin II) inhibited the increase in both ..
  38. Yared A, Kon V, Ichikawa I. Mechanism of preservation of glomerular perfusion and filtration during acute extracellular fluid volume depletion. Importance of intrarenal vasopressin-prostaglandin interaction for protecting kidneys from constrictor action of vasopressin. J Clin Invest. 1985;75:1477-87 pubmed
    ..028 +/- 0.003 vs. 0.087 +/- 0.011 nl/[s . mmHg]). Infusion of saralasin to these water-deprived rats resulted in significant increases in plasma flow rate and ultrafiltration ..
  39. Dostal D, Johnson J, Langevin P, Abas N. Hyperresponsiveness of arterial rings induced by renal prehypertensive rabbit plasma. Am J Physiol. 1988;255:H272-9 pubmed
    ..These studies demonstrated that the ANG II receptors involved in the hormonally mediated vascular hyperresponsiveness in 3-day RAS rabbits are contained in the tissues that comprise these renal arterial rings. ..
  40. Diebold H, Moreau D, Chardigny J, Rochette L. [Direct cardiac effects of angiotensins I and II and 2 converting enzyme inhibitors (captopril and perindopril). Indirect demonstration of a converting enzyme in the rat heart]. Arch Mal Coeur Vaiss. 1988;81 Spec No:29-32 pubmed
    ..the changes on the working heart caused by short perfusions of AI or AII (10(-7) M) in the presence of IEC or saralasin (SAR 10(-7) M). AII caused a reduction of the QCORO of 2.1 +/- 0.26 ml/mn, an increase of the QAO of 2.5 +/- 0...
  41. Dudley D, Summerfelt R. Regulated expression of angiotensin II (AT2) binding sites in R3T3 cells. Regul Pept. 1993;44:199-206 pubmed
  42. Ohuchi N, Hayashi K, Koike K, Kizawa Y, Kusama T, Ohsawa M, et al. Pharmacological properties of angiotensin II receptors in cultured rabbit gingival fibroblasts. Comp Biochem Physiol C Toxicol Pharmacol. 2004;137:281-9 pubmed
    ..The Ang II-induced proliferation was inhibited by CV-11974 (AT1 antagonist; 1 microM) and saralasin (AT1/AT2 antagonist; 1 microM), but not by PD123,319 (AT2 antagonist; 1 microM), suggesting that Ang II-induced ..
  43. Tanaka J, Hori K, Nomura M. Diminished salt appetite in spontaneously hypertensive rats following local administration of the angiotensin II antagonist saralasin in the median preoptic area. Behav Pharmacol. 1997;8:752-6 pubmed
    ..The present study was designed to test whether treatment with saralasin (Sar), an ANG II antagonist, in the MnPO area causes changes in saline (0...
  44. Matrougui K, Loufrani L, Heymes C, Levy B, Henrion D. Activation of AT(2) receptors by endogenous angiotensin II is involved in flow-induced dilation in rat resistance arteries. Hypertension. 1999;34:659-65 pubmed
    ..losartan) had no significant effect, whereas angiotensin II type 2 (AT(2)) receptor blockade (PD123319) or saralasin (AT(1)+AT(2) blocker) decreased the diameter significantly, by 9+/-1 and 10+/-0.8 microm, respectively...
  45. Tsuchida S, Matsusaka T, Chen X, Okubo S, Niimura F, Nishimura H, et al. Murine double nullizygotes of the angiotensin type 1A and 1B receptor genes duplicate severe abnormal phenotypes of angiotensinogen nullizygotes. J Clin Invest. 1998;101:755-60 pubmed
    ..Also, unlike Agt-/- mice, some Agtr1a-/-; Agtr1b-/- mice have a large ventricular septum defect, suggesting that another receptor such as AT2 is functionally activated in Agtr1a-/-, Agtr1b-/- mice. ..
  46. Guimaraes S, Paiva M, Moura D. Different receptors for angiotensin II at pre- and postjunctional level of the canine mesenteric and pulmonary arteries. Br J Pharmacol. 1998;124:1207-12 pubmed
    ..Postjunctionally, angiotensin II caused concentration-dependent contractions (pD2 = 8.57). Saralasin antagonized both pre- and postjunctional effects of angiotensin II, but it was more potent at post- than at ..
  47. Grant T, McGrath J. Interactions between angiotensin II, sympathetic nerve-mediated pressor response and cyclo-oxygenase products in the pithed rat. Br J Pharmacol. 1988;95:1220-8 pubmed
    ..4. The angiotensin converting enzyme inhibitor, teprotide, and the AII-receptor antagonist, saralasin, lowered the diastolic blood pressure and attenuated sympathetic nerve-mediated pressor responses...
  48. Gruber K, Callahan M, Eskridge Sloop S. Central administration of angiotensin II receptor antagonists and arterial pressure regulation: a note of caution. Life Sci. 1992;50:1497-502 pubmed
    ..An alternative hypothesis is that centrally administered AII antagonists non-specifically inhibit sympathetic nervous system function. ..
  49. Silldorff E, Stephens G. The pressor response to exogenous angiotensin I and its blockade by angiotensin II analogues in the American alligator. Gen Comp Endocrinol. 1992;87:141-8 pubmed
  50. Bunn S, Marley P. Effects of angiotensin II on cultured, bovine adrenal medullary cells. Neuropeptides. 1989;13:121-32 pubmed
    ..They do not support the suggestion that the secretory actions of angiotensin II on chromaffin cells are mediated by mobilization of intracellular Ca++ stores. ..
  51. Sandberg K, Ji H, Millan M, Catt K. Amphibian myocardial angiotensin II receptors are distinct from mammalian AT1 and AT2 receptor subtypes. FEBS Lett. 1991;284:281-4 pubmed
    ..These results indicate that amphibian AII receptors are pharmacologically distinct from both the AT1 and AT2 receptors characterized in mammalian tissues. ..
  52. Giometti I, Bertagnolli A, Ornes R, da Costa L, Carambula S, Reis A, et al. Angiotensin II reverses the inhibitory action produced by theca cells on bovine oocyte nuclear maturation. Theriogenology. 2005;63:1014-25 pubmed
    ..Bovine cumulus-oocyte complexes (COCs) were cultured with or without follicular cells and Ang II or saralasin (Ang II antagonist)...
  53. Delorenzi A, Maldonado H. Memory enhancement by the angiotensinergic system in the crab Chasmagnathus is mediated by endogenous angiotensin II. Neurosci Lett. 1999;266:1-4 pubmed
    ..that Dival, an ANGIV antagonist, reverts the facilitatory effect of ANGIV but not that of ANGII, whereas saralasin but not Dival, disrupts CSM...
  54. Tung J, Lang Y, Wang L, Chen C. Paraquat increases connective tissue growth factor and collagen expression via angiotensin signaling pathway in human lung fibroblasts. Toxicol In Vitro. 2010;24:803-8 pubmed publisher
    ..cells were incubated with various concentrations of paraquat with or without the ANG II receptor antagonist, saralasin. Paraquat increased ANG II production and AT1R mRNA and protein expression and decreased AT2R mRNA expression...
  55. Rothstein D, Spacciapoli P, Tran L, Xu T, Roberts F, Dalla Serra M, et al. Anticandida activity is retained in P-113, a 12-amino-acid fragment of histatin 5. Antimicrob Agents Chemother. 2001;45:1367-73 pubmed
    ..These results identify P-113 as a potential antimicrobial agent in the treatment of oral candidiasis. ..
  56. Tirapelli C, Fukada S, de Godoy M, de Oliveira A. Analysis of the mechanisms underlying the vasorelaxant action of angiotensin II in the isolated rat carotid. Life Sci. 2006;78:2676-82 pubmed
    ..The angiotensin II-induced relaxation was strongly inhibited by saralasin, the non-selective antagonist of angiotensin II receptors but not by the selective antagonists of AT1 and AT2 ..
  57. Georgiev V, Opitz M. Participation of angiotensin receptors in acute hypoxia in mice. I. Effects of angiotensin peptide receptor ligands saralasin and sarmesin. Methods Find Exp Clin Pharmacol. 1999;21:415-9 pubmed
    The effects of angiotensin II (Ang II) and angiotensin receptor ligands sarmesin ([Sar1, Tyr(Me)4] Ang II) and saralasin ([Sar1, Ala8] Ang II) administered intracerebroventricularly (i.c.v.) on acute anoxic hypoxia were studied in mice...
  58. Shimoni Y, Liu X. Role of PKC in autocrine regulation of rat ventricular K+ currents by angiotensin and endothelin. Am J Physiol Heart Circ Physiol. 2003;284:H1168-81 pubmed
    ..h) with the angiotensin-converting enzyme inhibitor quinapril or the angiotensin II (ANG II) receptor blocker saralasin. Western blots indicated a parallel increase in Kv4.2 and Kv1...
  59. Tanaka J, Miyakubo H, Fujisawa S, Nomura M. Reduced dipsogenic response induced by angiotensin II activation of subfornical organ projections to the median preoptic nucleus in estrogen-treated rats. Exp Neurol. 2003;179:83-9 pubmed
    ..In both groups of female rats, previous injections of saralasin (Sar, 10(-10) M, 0...
  60. Jennings D, Lockett H. Angiotensin stimulates respiration in spontaneously hypertensive rats. Am J Physiol Regul Integr Comp Physiol. 2000;278:R1125-33 pubmed
    ..SHR than in control Wistar-Kyoto (WKY) rats and 2) that intravenous infusion of the ANG II-receptor blocker saralasin would depress respiration in SHR, but not in WKY...
  61. Stancheva S, Alova L, Velkova M, Georgiev V. The effects of peptide and nonpeptide antagonists of angiotensin II receptors on the noradrenaline uptake of different brain structures in rats with angiotensin II-induced increase of water intake. Acta Physiol Pharmacol Bulg. 2003;27:65-8 pubmed
    ..The ANG II-receptor antagonists losartan, EXP 3174, sarmesin and saralasin decreased NA uptake in all brain regions studied as compared to the uptake in the same brain regions of ANG II-..
  62. Wagner C, Mohebbi N, Uhlig U, Giebisch G, Breton S, Brown D, et al. Angiotensin II stimulates H?-ATPase activity in intercalated cells from isolated mouse connecting tubules and cortical collecting ducts. Cell Physiol Biochem. 2011;28:513-20 pubmed publisher
    ..II was mediated through type 1 angiotensin II receptors (AT(1)-receptors) because it could be blocked by saralasin. Stimulation of H(+)-ATPase activity required an intact microtubular network--it was completely inhibited by ..
  63. Smith L, Ikegami M, Calvario G, Surdilla J, Ervin M. Renal responses to angiotensin II receptor blockade in ventilated preterm newborn lambs. Reprod Fertil Dev. 1999;11:419-24 pubmed
    ..One hour following delivery, animals were randomized to receive angiotensin II receptor-blockade (saralasin; 20 microg kg(-1) min(-1)) or saline (CON)...
  64. Badzynska B, Grzelec Mojzesowicz M, Dobrowolski L, Sadowski J. Differential effect of angiotensin II on blood circulation in the renal medulla and cortex of anaesthetised rats. J Physiol. 2002;538:159-66 pubmed
    ..E.M.), whereas MBF increased 12 +/- 2 % (both P < 0.001). Non-selective blockade of Ang II receptors with saralasin (3 microg kg(-1) min(-1) i.v.) increased RBF 12 +/- 2 % and decreased MBF 8 +/- 2 % (P < 0.001)...
  65. Ip S, Tsang S, Wong T, Che C, Leung P. Saralasin, a nonspecific angiotensin II receptor antagonist, attenuates oxidative stress and tissue injury in cerulein-induced acute pancreatitis. Pancreas. 2003;26:224-9 pubmed
    ..In the current study we hypothesized that inhibition of this renin-angiotensin system by saralasin, a nonspecific antagonist for angiotensin II receptor, could attenuate the severity of cerulein-induced ..
  66. Tanaka J, Miyakubo H, Hayashi Y. Decreased monoamine release in the median preoptic area following ventricular treatment with the angiotensin II antagonist saralasin in normotensive and spontaneously hypertensive rats. Regul Pept. 2002;107:71-7 pubmed
    ..normotensive Wistar-Kyoto (WKY) rats and SHR, we used microdialysis to investigate the effects of injections of saralasin (Sar), an angiotensin II (ANG II) antagonist, into the third ventricle (3V) on monoamine release in the MnPO ..
  67. Wilkes B, Masaro L, Schiller P, Carpenter K. Angiotensin II vs its type I antagonists: conformational requirements for receptor binding assessed from NMR spectroscopic and receptor docking experiments. J Med Chem. 2002;45:4410-8 pubmed
    ..Some differences were also noted. The terminal carboxyl of AII contacted Lys199 of the receptor while that of [Sar1,Val5,Ala8]-AII bridged Arg23 at the top of helix 1. The Asp1 side chain of AII interacted with His183 of the receptor. ..
  68. Wilcox C, Welch W. Thromboxane mediation of the pressor response to infused angiotensin II. Am J Hypertens. 1990;3:242-9 pubmed
    ..The increases in MAP and prostaglandin excretion produced by AII were reversed by the AII-receptor antagonist saralasin (10 micrograms/kg/min) while those produced by PE were reversed by the alpha-adrenoreceptor antagonist ..
  69. Tanaka J, Hori K, Nomura M. Dipsogenic response induced by angiotensinergic pathways from the lateral hypothalamic area to the subfornical organ in rats. Behav Brain Res. 2001;118:111-6 pubmed
    ..the LHA with efferent projections to the SFO to the drinking induced by ANG II, the effects of pretreatment with saralasin (Sar), a specific ANG II antagonist, in the SFO or its surrounding region on the drinking to ANG II were ..
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    ..The physiologic and clinical relevance of these observations depends on whether activation of new pressor protein can occur in vivo. ..
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    ..These effects were prevented by a non-specific antagonist of Ang II receptors (AT), saralasin. Adversely, PD123319, a specific inhibitor of AT2 receptors, augmented inhibition of ANP-dependent and enhanced ..
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    ..When ANG II was perfused in the continuous presence of saralasin, a non-selective ANG II receptor antagonist, we observed a faster but transient inhibition of HVA Ca2+ current...
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    ..of transmitter release produced by angiotensin II was prevented by the angiotensin receptor antagonist, saralasin. 4...
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    ..These findings are not compatible with the proposal that the mas oncogene is an angiotensin receptor, but suggest that expression of mas leads to increased responsiveness of the endogenous AII signaling system. ..
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    ..We found that, in rabbit S2 PT segments, luminal 10(-8) M saralasin (peptide antagonist of ANG II receptors), lowers baseline J(HCO(3)) (5% CO(2)) to the value normally seen at 0% ..