1 sarcosine 8 isoleucine angiotensin ii


Summary: An ANGIOTENSIN II analog which acts as a highly specific inhibitor of ANGIOTENSIN TYPE 1 RECEPTOR.

Top Publications

  1. Walters D, Speth R. Neuronal localization of specific angiotensin II binding sites in the rat inferior olivary nucleus. J Neurochem. 1988;50:812-7 pubmed
    ..These results indicate that specific angiotensin II binding sites in the inferior olivary nucleus occur exclusively on neuronal perikarya and/or dendrites. ..
  2. Patel J, Sekharam K, Block E. Oxidant injury increases cell surface receptor binding of angiotensin II to pulmonary artery endothelial cells. J Biochem Toxicol. 1990;5:253-8 pubmed
    ..In cells exposed to phospholipase A2, acetic acid treatment did not release cell-bound Ang II, and the remaining Ang II was recovered in the NaOH solubilized fraction.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  3. Ambroz C, Clark A, Catt K. The mas oncogene enhances angiotensin-induced [Ca2+]i responses in cells with pre-existing angiotensin II receptors. Biochim Biophys Acta. 1991;1133:107-11 pubmed
    ..These findings are not compatible with the proposal that the mas oncogene is an angiotensin receptor, but suggest that expression of mas leads to increased responsiveness of the endogenous AII signaling system. ..
  4. Bensoussan M, Mitchell T, Reilly T, Timmermans P, Verroust P, Ronco P. Immunological reactivity of angiotensin II receptor antagonists: possible implications for receptor binding sites. Eur J Pharmacol. 1993;247:169-75 pubmed
    ..abstract truncated at 250 words) ..
  5. Yoshimura Y, Karube M, Aoki H, Oda T, Koyama N, Nagai A, et al. Angiotensin II induces ovulation and oocyte maturation in rabbit ovaries via the AT2 receptor subtype. Endocrinology. 1996;137:1204-11 pubmed
    ..Thus, locally produced Ang II may be part of a novel intraovarian paracrine or autocrine control mechanism during the ovulatory process. ..
  6. McMullen J, Gibson K, Lumbers E, Burrell J. 125I[Sar(1)Ile(8)] angiotensin II has a different affinity for AT(1) and AT(2) receptor subtypes in ovine tissues. Regul Pept. 2002;105:83-92 pubmed
    ..In tissues which contained at least 10% of each receptor subtype, the corrected proportions were significantly altered (P<0.05), even in some tissues, to the extent of being reversed. ..
  7. Kuji N, Sueoka K, Miyazaki T, Tanaka M, Oda T, Kobayashi T, et al. Involvement of angiotensin II in the process of gonadotropin-induced ovulation in rabbits. Biol Reprod. 1996;55:984-91 pubmed
    ..Ang II produced locally by gonadotropin exposure may be a part of a novel intraovarian paracrine or autocrine control mechanism that operates via the AT2 receptor in the ovary. ..
  8. Nakano T, Yamamoto T, Fujioka H, Maeda J, Iwahashi N, Tamura S, et al. [A case report of high plasma renin activity in chronic pulmonary disease and the effect of angiotensin-II-analogue (1-sarcosine, 8-isoleucine-angiotensin-II)]. Nihon Kyobu Shikkan Gakkai Zasshi. 1990;28:605-11 pubmed
    ..The intravenous infusion of angiotensin-II-analogue (1-Sarcosine, 8-Isoleucine-Angiotensin-II) elicited an antagonistic blood pressure response resembling Bartter's syndrome. ..
  9. Wong N, Tsui J. Angiotensin II upregulates the expression of vasopressin V2 mRNA in the inner medullary collecting duct of the rat. Metabolism. 2003;52:290-5 pubmed
    ..These results suggested that PKA stimulates and PKC suppresses the expression of V2 mRNA in the IMCD of the kidney. ..

More Information


  1. Niebauer J, Tsao P, Lin P, Pratt R, Cooke J. Cholesterol-induced upregulation of angiotensin II and its effects on monocyte-endothelial interaction and superoxide production. Vasc Med. 2001;6:133-8 pubmed
    ..Ang II-antagonist inhibits free radical production and monocyte adhesion through a mechanism which may include PKC. ..
  2. Robberecht W, Andries M, Denef C. Stimulation of prolactin secretion from rat pituitary by luteinizing hormone-releasing hormone: evidence against mediation by angiotensin II acting through a (Sar1-Ala8)-angiotensin II-sensitive receptor. Neuroendocrinology. 1992;56:185-94 pubmed
    ..The involvement of AII acting on a non-(Sar1,Ala8)AII-sensitive receptor cannot be excluded and warrants further investigation. ..
  3. Usune S, Furukawa T. Effects of SC-52458, a new nonpeptide angiotensin II receptor antagonist, on increase in cytoplasmic Ca2+ concentrations and contraction induced by angiotensin II and K(+)-depolarization in guinea-pig taenia coli. Gen Pharmacol. 1996;27:1179-85 pubmed
    ..4. SC-52458 suppressed both the contraction and increase of [Ca2+]i by antagonizing AT1 receptors in the smooth muscle. ..
  4. Sato T, Niwa M, Himeno A, Tsutsumi K, Amemiya T. Quantitative receptor autoradiographic analysis for angiotensin II receptors in bovine retinal microvessels: quantitation with radioluminography. Cell Mol Neurobiol. 1993;13:233-45 pubmed
    ..Knowledge of the existence of large numbers of specific binding sites, candidates of physiologically active angiotensin II receptors, aids with understanding the regulatory roles of angiotensin II in the blood-retinal barrier. ..
  5. Smith R. Identification of atypical (non-AT1, non-AT2) angiotensin binding sites with high affinity for angiotensin I on IEC-18 rat intestinal epithelial cells. FEBS Lett. 1995;373:199-202 pubmed
  6. Viswanathan M, Selby D, Ray P. Expression of renal and vascular angiotensin II receptor subtypes in children. Pediatr Nephrol. 2000;14:1030-6 pubmed
    ..These findings demonstrate that the expression of Ang II receptor subtypes in different vascular structures in young children varies according to the tissue. ..
  7. Johren O, Hauser W, Saavedra J. Chemical lesion of the inferior olive reduces [125I]sarcosine1-angiotensin II binding to AT2 receptors in the cerebellar cortex of young rats. Brain Res. 1998;793:176-86 pubmed
  8. Touyz R, He G, Deng L, Schiffrin E. Role of extracellular signal-regulated kinases in angiotensin II-stimulated contraction of smooth muscle cells from human resistance arteries. Circulation. 1999;99:392-9 pubmed
    ..ERKs, the signaling cascades characteristically associated with cell growth, may play an important role in Ang II-stimulated contraction of human VSMCs. ..
  9. Andrawis N, Dzau V, Pratt R. Autocrine stimulation of mas oncogene leads to altered growth control. Cell Biol Int Rep. 1992;16:547-56 pubmed
    ..Our results suggest that the transformed phenotype is due to the production of a mas receptor ligand distinct from angiotensin. ..
  10. Koziarz P, Beck J, Moore G. Reciprocal modulation of the binding of angiotensin agonists and antagonists to angiotensin receptors in smooth muscle. Gen Pharmacol. 1993;24:705-13 pubmed
    ..An emerging relationship between the actions of angiotensin peptides and non-peptide mimetics of angiotensin is presented. ..
  11. Weiland F, Verspohl E. Variety of angiotensin receptors in 3T3-L1 preadipose cells and differentiated adipocytes. Horm Metab Res. 2008;40:760-6 pubmed publisher
    ..The AT4 binding site seems to be one of the predominant receptors in adipose cells. Other degraded, but still bioactive peptides like ANG III, IV and ANG(1-7), activating receptors not influenced by ANG II, could be of importance. ..
  12. Potts P, Allen A, Horiuchi J, Dampney R. Does angiotensin II have a significant tonic action on cardiovascular neurons in the rostral and caudal VLM?. Am J Physiol Regul Integr Comp Physiol. 2000;279:R1392-402 pubmed
    ..The results indicate that the peptidic ANG receptor antagonists profoundly inhibit the tonic activity of cardiovascular but not respiratory neurons in the VLM and that these effects are independent of ANG II or ANG-(1---7) receptors. ..
  13. Wood J, Mah S, Schnell C. Comparison of the acute hypotensive effects of renin inhibition, converting enzyme inhibition, and angiotensin II antagonism in rats. J Cardiovasc Pharmacol. 1990;16 Suppl 4:S60-4 pubmed
    ..Renin inhibitors and nonpeptidic Ang II antagonists, devoid of agonistic properties, promise to be effective antihypertensive agents similar to the CEIs. ..
  14. Lazard D, Villageois P, Briend Sutren M, Cavaille F, Bottari S, Strosberg A, et al. Characterization of a membrane glycoprotein having pharmacological and biochemical properties of an AT2 angiotensin II receptor from human myometrium. Eur J Biochem. 1994;220:919-26 pubmed
    ..Treatment of the 125I-Sarile-labelled protein with N-glycanase caused a shift in its apparent molecular mass on SDS/PAGE from 66-70 kDa to 33 kDa. ..
  15. Briand V, Riva L, Galzin A. Characterization of the angiotensin II AT1 receptor subtype involved in DNA synthesis in cultured vascular smooth muscle cells. Br J Pharmacol. 1994;112:1195-201 pubmed
  16. Moulik S, Speth R, Turner B, Rowe B. Angiotensin II receptor subtype distribution in the rabbit brain. Exp Brain Res. 2002;142:275-83 pubmed
    ..Our results did identify new AT(2) binding sites in the superior colliculus and cerebral cortex, but it is clear that AT(2) binding in the rabbit brain is weak and is not as widely distributed as in the rat. ..
  17. Lin K, Chan S, Chan J. Tonic suppression of spontaneous baroreceptor reflex by endogenous angiotensins via AT(2) subtype receptors at nucleus reticularis ventrolateralis in the rat. Synapse. 2001;40:85-94 pubmed
    ..We conclude that under physiologic conditions both endogenous ANG II and ANG III may exert a tonic inhibitory modulation on the spontaneous BRR response by acting selectively on the AT(2) subtype receptors at the NRVL. ..
  18. Abiko M, Rodgers K, Campeau J, Nakamura R, diZerega G. Alterations of angiotensin II Receptor levels in sutured wounds in rat skin. J Invest Surg. 1996;9:447-53 pubmed
    ..Because these data are consistent with those observed after excisional wounding, temporal changes in AII receptor expression may be integral to the process of wound healing. ..
  19. Daud A, Bumpus F, Husain A. Characterization of angiotensin I-converting enzyme (ACE)-containing follicles in the rat ovary during the estrous cycle and effects of ACE inhibitor on ovulation. Endocrinology. 1990;126:2927-35 pubmed
    ..8 +/- 3.1 ova), suggesting that ACE inhibition does not modify the follicular selection process in a way that affects ovulation. This may explain the lack of any reports of adverse effects of clinically used ACE inhibitors on ovulation. ..
  20. Qadri F, Badoer E, Stadler T, Unger T. Angiotensin II-induced noradrenaline release from anterior hypothalamus in conscious rats: a brain microdialysis study. Brain Res. 1991;563:137-41 pubmed
    ..They support the hypothesis that hypothalamic noradrenergic mechanisms are involved in the central actions of this peptide. ..
  21. Amiri F, Garcia R. Regulation of angiotensin II receptors and PKC isoforms by glucose in rat mesangial cells. Am J Physiol. 1999;276:F691-9 pubmed
    ..We conclude that MCs grown in high glucose concentration show altered ANG II receptor regulation as well as PKC isoform translocation compared with cells grown in normal glucose concentration. ..
  22. Pucell A, Bumpus F, Husain A. Regulation of angiotensin II receptors in cultured rat ovarian granulosa cells by follicle-stimulating hormone and angiotensin II. J Biol Chem. 1988;263:11954-61 pubmed
    ..If these regulatory mechanisms exist in the FSH-sensitive healthy follicle, our findings suggest that in the process of maturation, healthy and dominant follicles may become decoupled from angiotensinergic influences. ..
  23. Rowe B, Saylor D, Speth R, Absher D. Angiotensin-(1-7) binding at angiotensin II receptors in the rat brain. Regul Pept. 1995;56:139-46 pubmed
    ..For biological responses where Ang-(1-7) is reported to be equipotent with AII, it is unlikely that these actions are mediated by the widely distributed AT1 or AT2 receptor subtypes which recognize 125I Sar1 Ile8 AII. ..
  24. Chan Y, Chatsudthipong V, Wang T. Angiotensin receptor mediated regulation of transport in the rat proximal tubule. Prog Clin Biol Res. 1988;258:149-60 pubmed
    ..This rise in cytosolic Ca+2 initiates the activation of calmodulin-regulated enzymes. This then leads to inhibition of both JV and JHCO3-. ..
  25. Kalenga M, De Gasparo M, Whitebread S, Vankrieken L, Thomas K, De Hertogh R. [Identification of angiotensin II receptor and determination of its subtypes in rabbit and guinea pig fetal tissue]. Reprod Nutr Dev. 1992;32:47-54 pubmed
    ..These findings indicate that rabbit fetal placenta and chorion and guinea pig chorion are the most important sites of action for the renin-angiotensin system present in trophoblastic tissues. ..
  26. Riediger T, Rauch M, Schmid H. Actions of amylin on subfornical organ neurons and on drinking behavior in rats. Am J Physiol. 1999;276:R514-21 pubmed
    ..These results point to the SFO as a sensory central nervous target for amylin released systemically in response to metabolic changes. Furthermore, we suggest that amylin release during food intake may stimulate prandial drinking. ..
  27. Dostal D, Johnson J, Langevin P, Abas N. Hyperresponsiveness of arterial rings induced by renal prehypertensive rabbit plasma. Am J Physiol. 1988;255:H272-9 pubmed
    ..These studies demonstrated that the ANG II receptors involved in the hormonally mediated vascular hyperresponsiveness in 3-day RAS rabbits are contained in the tissues that comprise these renal arterial rings. ..
  28. Takei Y, Hasegawa Y. Vasopressor and depressor effects of native angiotensins and inhibition of these effects in the Japanese quail. Gen Comp Endocrinol. 1990;79:12-22 pubmed
    ..These results indicate that vascular ANG II receptors and ANG I converting enzyme in the quail may be different from those in mammals. ..
  29. Grove K, Cook V, Speth R. Angiotensin II receptor development in the bed nucleus of the stria terminalis and other perihypothalamic brain regions of the female and male rat. Neuroendocrinology. 1992;56:169-77 pubmed
    ..The developmental expression of AII receptors in the BSTV and SCh may therefore play a role in sexual maturation and regulation of sexual function in the rat. ..
  30. Brechler V, Jones P, Levens N, De Gasparo M, Bottari S. Agonistic and antagonistic properties of angiotensin analogs at the AT2 receptor in PC12W cells. Regul Pept. 1993;44:207-13 pubmed
    ..We found CGP 42112 to behave as a full agonist in this system, whereas PD 123319 and Sar Ile angiotensin II act as antagonists. As expected, the AT1 antagonist losartan did not affect this response. ..
  31. Maggi M, Finetti G, Cioni A, Mancina R, Baldi E, Serio M, et al. Identification and characterization of functional angiotensin II receptors in human neuroblastoma cells. Regul Pept. 1995;56:175-84 pubmed
    ..In neuroblastoma cells, AII does not stimulate DNA synthesis, suggesting other roles rather than mitogenesis. Neuroblastoma cells represents an interesting model to investigate the function of AII in neural crest derived tissues. ..
  32. Paradis P, Dali Youcef N, Paradis F, Thibault G, Nemer M. Overexpression of angiotensin II type I receptor in cardiomyocytes induces cardiac hypertrophy and remodeling. Proc Natl Acad Sci U S A. 2000;97:931-6 pubmed
    ..The data demonstrate a direct myocardial role for AII in the development of cardiac hypertrophy and failure and provide a useful model to elucidate the mechanisms of action of AII in the pathogenesis of cardiac diseases. ..
  33. Pendleton R, Gessner G, Horner E. Studies on inhibition of angiotensin II receptors in rabbit adrenal and aorta. J Pharmacol Exp Ther. 1989;248:637-43 pubmed
    ..Phe4,Tyr8AII behaves as a reversible, competitive inhibitor of AII binding, whereas Sar1,Leu8AII combines with the AII receptor in a slowly dissociable manner and is therefore not readily displaced by AII. ..
  34. Kuwahara M, Miyaji T, Tsubone H. Angiotensin II type 1 receptor-mediated increase in cytosolic Ca(2+) and proliferation in mesothelial cells. Eur J Pharmacol. 2000;388:21-7 pubmed
    ..These results suggest that angiotensin II-induced responses to mesothelial cells are extremely dependent on the angiotensin AT(1) receptor coupled with pertussis toxin-insensitive G protein. ..
  35. Sandberg K, Ji H, Millan M, Catt K. Amphibian myocardial angiotensin II receptors are distinct from mammalian AT1 and AT2 receptor subtypes. FEBS Lett. 1991;284:281-4 pubmed
    ..These results indicate that amphibian AII receptors are pharmacologically distinct from both the AT1 and AT2 receptors characterized in mammalian tissues. ..
  36. Soltis E, Cassis L. Influence of perivascular adipose tissue on rat aortic smooth muscle responsiveness. Clin Exp Hypertens A. 1991;13:277-96 pubmed
    ..These observations demonstrate that perivascular adipose tissue significantly influences vascular responsiveness in the in vitro setting. ..
  37. MacLean M, Raizada M, Sumners C. The influence of angiotensin II on catecholamine synthesis in neuronal cultures from rat brain. Biochem Biophys Res Commun. 1990;167:492-7 pubmed
  38. Morita T, Kikuchi T, Hara Y, Ishikawa S, Kobayashi Y, Ishiyama S, et al. Intraarterial infusion chemotherapy with [Sar1,Ile8]angiotensin II for bladder cancer. Am J Clin Oncol. 1992;15:188-93 pubmed
    ..We conclude that intraarterial infusion chemotherapy combined with a vasoconstrictor has a significant effect not only against multifocal superficial bladder cancer but also against invasive bladder cancer. ..
  39. Kalenga M, De Gasparo M, De Hertogh R, Whitebread S, Vankrieken L, Thomas K. [Angiotensin II receptors in the human placenta are type AT1]. Reprod Nutr Dev. 1991;31:257-67 pubmed
    ..15 nmol.l-1 indicate that the highest concentrations of angiotensin II receptors are found in placental villous tissues. ..
  40. Sechi L, Grady E, Griffin C, Kalinyak J, Schambelan M. Distribution of angiotensin II receptor subtypes in rat and human kidney. Am J Physiol. 1992;262:F236-40 pubmed
    ..The distribution of angiotensin II receptors correlates well with the intrarenal sites at which the peptide has its major physiological effects. ..
  41. Gruber K, Callahan M, Eskridge Sloop S. Central administration of angiotensin II receptor antagonists and arterial pressure regulation: a note of caution. Life Sci. 1992;50:1497-502 pubmed
    ..An alternative hypothesis is that centrally administered AII antagonists non-specifically inhibit sympathetic nervous system function. ..
  42. Silldorff E, Stephens G. The pressor response to exogenous angiotensin I and its blockade by angiotensin II analogues in the American alligator. Gen Comp Endocrinol. 1992;87:141-8 pubmed
  43. Nozawa Y, Matsuura N, Miyake H, Yamada S, Kimura R. Effects of TH-142177 on angiotensin II-induced proliferation, migration and intracellular signaling in vascular smooth muscle cells and on neointimal thickening after balloon injury. Life Sci. 1999;64:2061-70 pubmed
    ..Thus, TH-142177 may have therapeutic potential for the treatment of vascular diseases such as atherosclerosis and restenosis. ..
  44. Crandall D, Herzlinger H, Saunders B, Zolotor R, Feliciano L, Cervoni P. Identification and characterization of angiotensin II receptors in rat epididymal adipocyte membranes. Metabolism. 1993;42:511-5 pubmed
  45. Clark A, Balla T, Jones M, Catt K. Stimulation of early gene expression by angiotensin II in bovine adrenal glomerulosa cells: roles of calcium and protein kinase C. Mol Endocrinol. 1992;6:1889-98 pubmed
  46. Kuwahara M, Kuwahara M. Involvement of Rho and tyrosine kinase in angiotensin II-induced actin reorganization in mesothelial cells. Eur J Pharmacol. 2002;436:15-21 pubmed
  47. Näveri L, Stromberg C, Saavedra J. Angiotensin II AT2 receptor stimulation extends the upper limit of cerebral blood flow autoregulation: agonist effects of CGP 42112 and PD 123319. J Cereb Blood Flow Metab. 1994;14:38-44 pubmed
    ..These results suggest that both CGP 42112 and PD 123319 exert their effects on CBF autoregulation through stimulation of angiotensin II AT2 receptors. The mechanism by which losartan affects CBF remains unclear. ..
  48. Kocsis J, Schimmel R, McIlroy P, Carsia R. Dissociation of increases in intracellular calcium and aldosterone production induced by angiotensin II (AII): evidence for regulation by distinct AII receptor subtypes or isomorphs. Endocrinology. 1995;136:1626-34 pubmed
    ..Taken collectively, the data suggest that in turkey adrenocortical cells, elevations in [Ca2+]i and aldosterone production are dissociable events regulated by distinct AII receptor subtypes or isomorphs. ..
  49. Aplin M, Christensen G, Schneider M, Heydorn A, Gammeltoft S, Kjølbye A, et al. Differential extracellular signal-regulated kinases 1 and 2 activation by the angiotensin type 1 receptor supports distinct phenotypes of cardiac myocytes. Basic Clin Pharmacol Toxicol. 2007;100:296-301 pubmed
    ..The opportunity to separate desirable cardiac myocyte division from detrimental hypertrophy holds promise that novel pharmacological approaches will allow targeting of pathway-specific actions. ..
  50. Grove K, Mayo R, Forsyth C, Frank A, Speth R. Fosinopril treatment of pregnant rats: developmental toxicity, fetal angiotensin-converting enzyme inhibition, and fetal angiotensin II receptor regulation. Toxicol Lett. 1995;80:85-95 pubmed
    ..Fetal Ang II receptor binding of 125I-Sar1,Ile8 Ang II was not altered in most of the tissues examined, although reductions in binding in the adrenal of fetuses of fosinopril-treated dams approached statistical significance. ..
  51. Fujie M, Ichikawa S, Sakamaki T, Kogure M, Fujita H, Nakamura T, et al. Role of baroreflex in the pressor response of rats with hypertension developed by renal artery stenosis. Life Sci. 1988;42:759-67 pubmed
  52. Chobanian M, Julin C. Angiotensin II stimulates ammoniagenesis in canine renal proximal tubule segments. Am J Physiol. 1991;260:F19-26 pubmed
    ..Stimulation of ammoniagenesis in vitro under normal and acidotic conditions may reflect a role in vivo for ANG II in the regulation of renal acid-base metabolism. ..
  53. Rowe B, Grove K, Saylor D, Speth R. Angiotensin II receptor subtypes in the rat brain. Eur J Pharmacol. 1990;186:339-42 pubmed
  54. Morita T, Kikuchi T, Hara Y, Ishikawa S, Kobayashi Y, Ishiyama S, et al. [Intra-arterial infusion chemotherapy with [Sar1, Ile8] angiotensin II in bladder cancer]. Gan To Kagaku Ryoho. 1989;16:3417-22 pubmed
    ..This study demonstrated that intra-arterial infusion chemotherapy with CDDP and ADM in combination with [Sar1, Ile8] angiotensin II was extremely effective in treating patients with bladder cancer. ..
  55. Fluharty S, Reagan L. Characterization of binding sites for the angiotensin II antagonist 125I-[Sarc1,Ile8]-angiotensin II on murine neuroblastoma N1E-115 cells. J Neurochem. 1989;52:1393-400 pubmed
    ..Collectively, these results suggest that the murine neuroblastoma N1E-115 cell line may provide a useful model in which to investigate the signal transduction mechanisms utilized by neuronal Ang II receptors. ..
  56. Brassard P, Amiri F, Schiffrin E. Combined angiotensin II type 1 and type 2 receptor blockade on vascular remodeling and matrix metalloproteinases in resistance arteries. Hypertension. 2005;46:598-606 pubmed
    ..Changes in vascular wall mechanics, ECM deposition, and MMP activity are thus modulated differentially by Ang II receptors. ..
  57. Song K, Allen A, Paxinos G, Mendelsohn F. Angiotensin II receptor subtypes in rat brain. Clin Exp Pharmacol Physiol. 1991;18:93-6 pubmed
    ..5. These results reveal important pharmacological heterogeneity of brain AII receptors which suggest different regional functions and are relevant to the central actions of emerging classes of new non-peptide AII receptor antagonists. ..
  58. Ciuffo G, Alvarez S, Fuentes L. Angiotensin II receptors induce tyrosine dephosphorylation in rat fetal membranes. Regul Pept. 1998;74:129-35 pubmed
    ..These results clearly indicate that both Ang II receptors mediate tyrosine dephosphorylation in early stages of development and support a role of these receptors in growth and development. ..
  59. Handa R, Johns E. The role of angiotensin II in the renal responses to somatic nerve stimulation in the rat. J Physiol. 1987;393:425-36 pubmed
  60. Soualmia H, Masson F, Barthelemy C, Maistre G, Carayon A. Cellular mechanism of angiotensin II-induced atrial natriuretic peptide release in rat right atrial tissue. Life Sci. 1996;58:1621-9 pubmed
    ..These results suggest that PKC and intracellular calcium play an important role in ANP release under the influence of Ang II in rat atrial tissue. ..
  61. Breno M, Porto C, Picarelli Z. Angiotensin receptor in the heart of Bothrops jararaca snake. Eur J Pharmacol. 2001;417:27-35 pubmed
    ..jararaca snake pharmacologically distinct from angiotensin AT1 and AT2 receptors. It seems to belong to a new class of angiotensin receptors, like some other atypical angiotensin AT receptors that have already been described. ..
  62. Hunyady L, Bor M, Baukal A, Balla T, Catt K. A conserved NPLFY sequence contributes to agonist binding and signal transduction but is not an internalization signal for the type 1 angiotensin II receptor. J Biol Chem. 1995;270:16602-9 pubmed
    ..However, the Phe301 residue contributes significantly to agonist binding, and Asn298 is required for normal receptor activation and signal transduction. ..
  63. Dhanoa D, Bagley S, Chang R, Lotti V, Chen T, Kivlighn S, et al. Non-peptide angiotensin II receptor antagonists. 2. Design, synthesis, and biological activity of N-substituted (phenylamino)phenylacetic acids and acyl sulfonamides. J Med Chem. 1993;36:4239-49 pubmed
    ..0 mg/kg dose level. Both acyl sulfonamides 16a and 16c exhibited superior in vivo activity in rats compared to that of (phenylamino)phenylacetic acid 9c. ..
  64. Tallam L, Jandhyala B. Significance of exaggerated natriuresis after angiotensin AT1 receptor blockade or angiotensin- converting enzyme inhibition in obese Zucker rats. Clin Exp Pharmacol Physiol. 2001;28:433-40 pubmed
    ..It is proposed this phenomenon may be a contributing factor for the salt- sensitivity in the OZR. ..
  65. Allen A. Angiotensin AT1 receptor-mediated excitation of rat carotid body chemoreceptor afferent activity. J Physiol. 1998;510 ( Pt 3):773-81 pubmed
    ..This provides a means whereby humoral information about fluid and electrolyte homeostasis might influence control of cardiorespiratory function. ..
  66. Rowe B, Saylor D, Speth R. Analysis of angiotensin II receptor subtypes in individual rat brain nuclei. Neuroendocrinology. 1992;55:563-73 pubmed
    ..However, the unexpected finding that they can be differentiated on the basis of their affinity for 125I SIAII raises questions concerning their coidentity with peripheral receptor subtypes. ..
  67. Aiyar N, Baker E, Pullen M, Nuthulaganti P, Bergsma D, Kumar C, et al. Characterization of a functional angiotensin II receptor in Xenopus laevis heart. Pharmacology. 1994;48:242-9 pubmed
    ..Together, these results demonstrate that Xenopus heart AII receptors are functionally similar to mammalian AT1 receptors but are pharmacologically distinct from both AT1 and AT2 receptors. ..
  68. Finocchiaro L, Goldstein D, Finkielman S, Nahmod V. Interaction of angiotensin II with the cholinergic and noradrenergic systems in the rat pineal gland: regulation of indole metabolism. J Endocrinol. 1990;126:59-66 pubmed
    ..The stimulation of serotonin biosynthesis and release by these two neurotransmitters was negatively regulated by noradrenaline acting through beta-adrenergic receptors. ..
  69. Moeller I, Chai S, MacGregor D, Aldred G, Mendelsohn F. Localization and quantitation of angiotensin AT1 and AT2 receptors in the pregnant and non-pregnant sheep uterus. Regul Pept. 1996;61:213-8 pubmed
    ..These changes suggest that angiotensin II may be involved in regulating changes of uterine structure and function during pregnancy by interaction with multiple receptor subtypes. ..
  70. Zhuo J, Alcorn D, McCausland J, Casley D, Mendelsohn F. In vivo occupancy of angiotensin II subtype 1 receptors in rat renal medullary interstitial cells. Hypertension. 1994;23:838-43 pubmed
  71. Gosselin M, Leclerc P, Auger Messier M, Guillemette G, Escher E, Leduc R. Molecular cloning of a ferret angiotensin II AT(1) receptor reveals the importance of position 163 for Losartan binding. Biochim Biophys Acta. 2000;1497:94-102 pubmed
  72. Le M, De Backer J, Hunyady L, Vanderheyden P, Vauquelin G. Ligand binding and functional properties of human angiotensin AT1 receptors in transiently and stably expressed CHO-K1 cells. Eur J Pharmacol. 2005;513:35-45 pubmed
    ..Confocal microscopy revealed rapid internalization induced by angiotensin II and sarile but not by candesartan. The above disparities may result from differences in receptor maturation and/or cellular surrounding. ..
  73. Takeda K, Okajima H, Nakata T, Kawasaki S, Hayashi J, Oguro M, et al. Clonidine abolishes exaggerated pressor responses to shaker stress in spontaneously hypertensive rats. Am J Hypertens. 1990;3:39-44 pubmed
    ..These findings suggest that in SHR, the alpha-adrenergic system in the brain may contribute to exaggerated pressor responses to shaker stress, but not the brain renin-angiotensin system. ..
  74. Grove K, Cook V, Speth R. Angiotensin II receptors in the ventral portion of the bed nucleus of the stria terminalis. Neuroendocrinology. 1991;53:339-43 pubmed
    ..The selective nonpeptidic Ang II alpha receptor antagonist Dup 753 completely inhibited the binding of 125I-SI Ang II to the BSTV and other hypothalamic nuclei, suggesting that these receptors are of the Ang II alpha subtype. ..
  75. Saigusa T, Granger N, Godwin S, Head G. The rostral ventrolateral medulla mediates sympathetic baroreflex responses to intraventricular angiotensin II in rabbits. Auton Neurosci. 2003;107:20-31 pubmed
    ..These studies suggest that the major medullary pressor site of action of Ang II when injected into the hindbrain cerebro-spinal fluid of anaesthetized rabbits is the RVLM where it facilitates baroreflex control of RSNA. ..
  76. Morinelli T, Kendall R, Luttrell L, Walker L, Ullian M. Angiotensin II-induced cyclooxygenase 2 expression in rat aorta vascular smooth muscle cells does not require heterotrimeric G protein activation. J Pharmacol Exp Ther. 2009;330:118-24 pubmed publisher
    ..These data suggest that G protein activation results in increased COX-2 protein expression, but AngII-induced COX-2 expression seems to occur independently of G protein activation. ..
  77. Walsh D, Hu D, Wharton J, Catravas J, Blake D, Fan T. Sequential development of angiotensin receptors and angiotensin I converting enzyme during angiogenesis in the rat subcutaneous sponge granuloma. Br J Pharmacol. 1997;120:1302-11 pubmed
    ..Pharmacological modulation of this balance may provide novel therapeutic approaches in angiogenesis-dependent diseases. ..
  78. Beauchamp H, Chang R, Siegl P, Gibson R. In vivo receptor occupancy of the angiotensin II receptor by nonpeptide antagonists: relationship to in vitro affinities and in vivo pharmacologic potency. J Pharmacol Exp Ther. 1995;272:612-8 pubmed
  79. Tallant E, Diz D, Khosla M, Ferrario C. Identification and regulation of angiotensin II receptor subtypes on NG108-15 cells. Hypertension. 1991;17:1135-43 pubmed
    ..Ang II also mobilized intracellular Ca2+ in differentiated NG108-15 cells.(ABSTRACT TRUNCATED AT 250 WORDS) ..
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    ..These results demonstrate that AT1 receptor subtypes are present in intact rat proximal tubule cells and are coupled to both IPs-Ca2+ and cAMP signaling pathways. No evidence for AT2 receptor subtype is found. ..
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    ..Finally, we showed that downregulation of angiotensinogen synthesized by astroglial cells differentially regulates angiotensin receptor subtypes inside the brain and in circumventricular organs. ..
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    ..In conclusion, we have isolated a novel protein that interacts specifically with the carboxyl-terminal cytoplasmic domain of the AT1a receptor and affects AT1a receptor signaling. ..
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    ..As the predominant receptor isoform in the adult kidney, the AT1A receptor may account for the majority of the effects of Ang II on glomerular and tubular function. ..
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    ..It appears that the peripheral renin angiotensin system is not necessary for insulin-induced drinking but central angiotensin II plays an important role. ..
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    ..The functional significance of this binding site, either as a novel angiotensin receptor or a highly specific angiotensinase remains to be determined. ..
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    ..Elevated c-src expression with angiotensin system inhibition may act to enhance intimal wound closure and to reduce luminal thrombogenicity in vivo. ..
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    ..This decrease, which was prevented by angiotensin II treatment, suggests the existence of an unknown endogenous factor which, like the AT2 receptor ligands, seems to prevent AT2 receptor degradation. ..
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    ..In addition, the high density of Ang II receptors on the follicle cells emphasizes the necessity for care in using Xenopus oocytes for the expression of receptors encoded by exogenous RNAs. ..