angiotensin ii

Summary

Summary: An octapeptide that is a potent but labile vasoconstrictor. It is produced from angiotensin I after the removal of two amino acids at the C-terminal by ANGIOTENSIN CONVERTING ENZYME. The amino acid in position 5 varies in different species. To block VASOCONSTRICTION and HYPERTENSION effect of angiotensin II, patients are often treated with ACE INHIBITORS or with ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS.

Top Publications

  1. Remus E, Lyle A, Weiss D, Landàzuri N, Weber M, SEARLES C, et al. miR181a protects against angiotensin II-induced osteopontin expression in vascular smooth muscle cells. Atherosclerosis. 2013;228:168-74 pubmed publisher
    Osteopontin (OPN) is a multifunctional protein found in abundance in atherosclerotic plaques. Angiotensin II (Ang II) promotes atherosclerosis by inducing adhesion and migration of vascular smooth muscle cells (VSMCs)...
  2. Hua P, Feng W, Rezonzew G, Chumley P, Jaimes E. The transcription factor ETS-1 regulates angiotensin II-stimulated fibronectin production in mesangial cells. Am J Physiol Renal Physiol. 2012;302:F1418-29 pubmed publisher
    b>Angiotensin II (ANG II) produced as result of activation of the renin-angiotensin system (RAS) plays a critical role in the pathogenesis of chronic kidney disease via its hemodynamic effects on the renal microcirculation as well as by its ..
  3. Chen H, Xu Z, Chen L, Wang W, Fang Q, Yan X. Valsartan and telmisartan abrogate angiotensin II-induced downregulation of ABCA1 expression via AT1 receptor, rather than AT2 receptor or PPAR? activation. J Cardiovasc Pharmacol. 2012;59:570-5 pubmed publisher
    The possible pharmacological mechanism by which partial PPAR?-activating angiotensin II (Ang II) type 1 receptor blocker (ARB) telmisartan and non-PPAR?-activating ARB valsartan reverse Ang II-suppressed ABCA1 expression is still unclear...
  4. Krebs C, Lange S, Niemann G, Rosendahl A, Lehners A, Meyer Schwesinger C, et al. Deficiency of the interleukin 17/23 axis accelerates renal injury in mice with deoxycorticosterone acetate+angiotensin ii-induced hypertension. Hypertension. 2014;63:565-71 pubmed publisher
    T cells participate in angiotensin II (Ang II)-induced hypertension. However, the specific subsets of T cells that are important in the end-organ damage are unknown...
  5. Fan F, Sun C, Maier K, Williams J, Pabbidi M, Didion S, et al. 20-Hydroxyeicosatetraenoic acid contributes to the inhibition of K+ channel activity and vasoconstrictor response to angiotensin II in rat renal microvessels. PLoS ONE. 2013;8:e82482 pubmed publisher
    ..study examined whether 20-hydroxyeicosatetraenoic acid (HETE) contributes to the vasoconstrictor effect of angiotensin II (ANG II) in renal microvessels by preventing activation of the large conductance Ca(2+)-activated K(+) channel ..
  6. Hausding M, Jurk K, Daub S, Kröller Schön S, Stein J, Schwenk M, et al. CD40L contributes to angiotensin II-induced pro-thrombotic state, vascular inflammation, oxidative stress and endothelial dysfunction. Basic Res Cardiol. 2013;108:386 pubmed publisher
    ..However, the role of CD40L in angiotensin II (ATII)-driven vascular dysfunction and hypertension remains incompletely understood...
  7. Wakui H, Dejima T, Tamura K, Uneda K, Azuma K, Maeda A, et al. Activation of angiotensin II type 1 receptor-associated protein exerts an inhibitory effect on vascular hypertrophy and oxidative stress in angiotensin II-mediated hypertension. Cardiovasc Res. 2013;100:511-9 pubmed publisher
    Activation of tissue angiotensin II (Ang II) type 1 receptor (AT1R) plays an important role in the development of vascular remodelling...
  8. Wang D, Hu S, Zhu J, Yuan J, Wu J, Zhou A, et al. Angiotensin II type 2 receptor correlates with therapeutic effects of losartan in rats with adjuvant-induced arthritis. J Cell Mol Med. 2013;17:1577-87 pubmed publisher
    The angiotensin II type 1 receptor (AT1R) blocker losartan ameliorates rheumatoid arthritis (RA) in an experimental model. In RA, AT2R mainly opposes AT1R, but the mechanism by which this occurs still remains obscure...
  9. Tsai S, Huang P, Peng Y, Chang W, Tsai H, Leu H, et al. Zoledronate attenuates angiotensin II-induced abdominal aortic aneurysm through inactivation of Rho/ROCK-dependent JNK and NF-?B pathway. Cardiovasc Res. 2013;100:501-10 pubmed publisher
    ..Here, we tested whether a potent N-BP, zoledronate, can attenuate the formation of Angiotensin II (Ang II)-induced AAA in hyperlipidaemic mice...

More Information

Publications91

  1. Zeniya M, Sohara E, Kita S, Iwamoto T, Susa K, Mori T, et al. Dietary salt intake regulates WNK3-SPAK-NKCC1 phosphorylation cascade in mouse aorta through angiotensin II. Hypertension. 2013;62:872-8 pubmed publisher
    ..Acute and chronic angiotensin II infusion increased phosphorylation of SPAK and NKCC1 in the mouse aorta...
  2. Gonzalez Vicente A, Garvin J. Angiotensin II-induced hypertension increases plasma membrane Na pump activity by enhancing Na entry in rat thick ascending limbs. Am J Physiol Renal Physiol. 2013;305:F1306-14 pubmed publisher
    ..Chronic angiotensin II (ANG II) infusion increases net TAL Na transport and Na apical entry; however, little is known about its ..
  3. Patel V, Clarke N, Wang Z, Fan D, Parajuli N, Basu R, et al. Angiotensin II induced proteolytic cleavage of myocardial ACE2 is mediated by TACE/ADAM-17: a positive feedback mechanism in the RAS. J Mol Cell Cardiol. 2014;66:167-76 pubmed publisher
    ..In HF, elevated plasma ACE2 activity likely represents loss of the protective effects of ACE2 in the heart. ..
  4. Haack K, Mitra A, Zucker I. NF-?B and CREB are required for angiotensin II type 1 receptor upregulation in neurons. PLoS ONE. 2013;8:e78695 pubmed publisher
    ..like gene-1 (Elk-1) are two transcription factors that have been previously established to contribute to the Angiotensin II mediated upregulation of Angiotensin II type 1 receptor (AT1R) in neurons...
  5. Yan L, Zhang J, Wang B, Lv Y, Jiang H, Liu G, et al. Quercetin inhibits left ventricular hypertrophy in spontaneously hypertensive rats and inhibits angiotensin II-induced H9C2 cells hypertrophy by enhancing PPAR-? expression and suppressing AP-1 activity. PLoS ONE. 2013;8:e72548 pubmed publisher
    ..Our data indicate that quercetin may inhibit cardiac hypertrophy by enhancing PPAR-? expression and by suppressing the AP-1 signaling pathway. ..
  6. Lee D, Wauquier F, Eid A, Roman L, Ghosh Choudhury G, Khazim K, et al. Nox4 NADPH oxidase mediates peroxynitrite-dependent uncoupling of endothelial nitric-oxide synthase and fibronectin expression in response to angiotensin II: role of mitochondrial reactive oxygen species. J Biol Chem. 2013;288:28668-86 pubmed publisher
    Activation of glomerular mesangial cells (MCs) by angiotensin II (Ang II) leads to extracellular matrix accumulation...
  7. Bai J, Zhang N, Hua Y, Wang B, Ling L, Ferro A, et al. Metformin inhibits angiotensin II-induced differentiation of cardiac fibroblasts into myofibroblasts. PLoS ONE. 2013;8:e72120 pubmed publisher
    ..Our results provide new mechanistic insights regarding the cardioprotective effects of metformin and provide an efficient therapeutic strategy to attenuate cardiac fibrosis. ..
  8. Biancardi V, Son S, Ahmadi S, Filosa J, Stern J. Circulating angiotensin II gains access to the hypothalamus and brain stem during hypertension via breakdown of the blood-brain barrier. Hypertension. 2014;63:572-9 pubmed publisher
    b>Angiotensin II-mediated vascular brain inflammation emerged as a novel pathophysiological mechanism in neurogenic hypertension...
  9. Dikalov S, Nazarewicz R, Bikineyeva A, Hilenski L, LASSEGUE B, Griendling K, et al. Nox2-induced production of mitochondrial superoxide in angiotensin II-mediated endothelial oxidative stress and hypertension. Antioxid Redox Signal. 2014;20:281-94 pubmed publisher
    b>Angiotensin II (AngII)-induced superoxide (O2(•-)) production by the NADPH oxidases and mitochondria has been implicated in the pathogenesis of endothelial dysfunction and hypertension...
  10. Anderson M, Roshanravan H, Khine J, Dryer S. Angiotensin II activation of TRPC6 channels in rat podocytes requires generation of reactive oxygen species. J Cell Physiol. 2014;229:434-42 pubmed publisher
    b>Angiotensin II (AII) plays a major role in the progression of chronic kidney diseases. Podocytes are essential components of the ultrafiltration apparatus, and are targets for AII signaling...
  11. Zhang Y, Huang X, Wei L, Chung A, Yu C, Lan H. miR-29b as a therapeutic agent for angiotensin II-induced cardiac fibrosis by targeting TGF-?/Smad3 signaling. Mol Ther. 2014;22:974-85 pubmed publisher
    ..This study examined the role and therapeutic potential of miR-29 in mouse model of hypertension induced by angiotensin II (AngII)...
  12. Siddesha J, Valente A, Sakamuri S, Yoshida T, Gardner J, Somanna N, et al. Angiotensin II stimulates cardiac fibroblast migration via the differential regulation of matrixins and RECK. J Mol Cell Cardiol. 2013;65:9-18 pubmed publisher
    ..We hypothesized that elevated angiotensin II (Ang II), which is associated with fibrosis in the heart, differentially regulates MMPs and RECK both in vivo ..
  13. Wang X, Dai Y, Ding Z, Khaidakov M, Mercanti F, Mehta J. Regulation of autophagy and apoptosis in response to angiotensin II in HL-1 cardiomyocytes. Biochem Biophys Res Commun. 2013;440:696-700 pubmed publisher
    ..However, when anoxia (and thereby release of Ang II) is prolonged, the process of apoptosis dominates. These processes will determine the outcome of cardiomyocyte well-being in states of hypoxia. ..
  14. Chen D, Liu J, Rui B, Gao M, Zhao N, Sun S, et al. GSTpi protects against angiotensin II-induced proliferation and migration of vascular smooth muscle cells by preventing signal transducer and activator of transcription 3 activation. Biochim Biophys Acta. 2014;1843:454-63 pubmed publisher
    b>Angiotensin II (Ang II)-elicited excessive proliferation, hypertrophy and migration of vascular smooth muscle cells (VSMCs) are vital to the pathogenesis of atheroclerosis...
  15. Cizmeci D, Arkun Y. Regulatory networks and complex interactions between the insulin and angiotensin II signalling systems: models and implications for hypertension and diabetes. PLoS ONE. 2013;8:e83640 pubmed publisher
    The cross-talk between insulin and angiotensin II signalling pathways plays a significant role in the co-occurrence of diabetes and hypertension...
  16. Case A, Li S, Basu U, Tian J, Zimmerman M. Mitochondrial-localized NADPH oxidase 4 is a source of superoxide in angiotensin II-stimulated neurons. Am J Physiol Heart Circ Physiol. 2013;305:H19-28 pubmed publisher
    b>Angiotensin II (ANG II) plays an important role in the central regulation of systemic cardiovascular function...
  17. Messaoudi S, Zhang A, Griol Charhbili V, Escoubet B, Sadoshima J, Farman N, et al. The epidermal growth factor receptor is involved in angiotensin II but not aldosterone/salt-induced cardiac remodelling. PLoS ONE. 2012;7:e30156 pubmed publisher
    ..As previously reported, Angiotensin II-mediated cardiac remodelling was prevented in DN-EGFR mice...
  18. Raizada V, Hillerson D, Amaram J, Skipper B. Angiotensin II-mediated left ventricular abnormalities in chronic kidney disease. J Investig Med. 2012;60:785-91 pubmed publisher
    b>Angiotensin II (ATII), the biologically active product of the renin-angiotensin system (RAS), is involved in modulation of left ventricular (LV) structure and function in chronic kidney disease (CKD)...
  19. Yuen C, Wong S, Lau C, Tsang S, Xu A, Zhu Z, et al. From skeleton to cytoskeleton: osteocalcin transforms vascular fibroblasts to myofibroblasts via angiotensin II and Toll-like receptor 4. Circ Res. 2012;111:e55-66 pubmed publisher
    ..Small interfering RNA silencing of TLR4 and PKC? abolished fibroblast transformation. Angiotensin II level in the conditioned medium from the osteocalcin-treated fibroblasts was found elevated using enzyme ..
  20. Axelsson J, Rippe A, Oberg C, Rippe B. Rapid, dynamic changes in glomerular permeability to macromolecules during systemic angiotensin II (ANG II) infusion in rats. Am J Physiol Renal Physiol. 2012;303:F790-9 pubmed publisher
    The actions of systemic angiotensin II (ANG II) infusions on glomerular permeability were investigated in vivo...
  21. Sun H, Li P, Chen W, Xiong X, Han Y. Angiotensin II and angiotensin-(1-7) in paraventricular nucleus modulate cardiac sympathetic afferent reflex in renovascular hypertensive rats. PLoS ONE. 2012;7:e52557 pubmed publisher
    ..Ang-(1-7) in PVN potentiates the effects of Ang II in renovascular hypertension. ..
  22. Sopel M, Falkenham A, Oxner A, Ma I, Lee T, Legare J. Fibroblast progenitor cells are recruited into the myocardium prior to the development of myocardial fibrosis. Int J Exp Pathol. 2012;93:115-24 pubmed publisher
    Using an established model of myocardial hypertrophy and fibrosis after angiotensin II (AngII) infusion, our aim was to characterize the early cellular element involved in the development of myocardial fibrosis in detail...
  23. Chrissobolis S, Banfi B, Sobey C, Faraci F. Role of Nox isoforms in angiotensin II-induced oxidative stress and endothelial dysfunction in brain. J Appl Physiol (1985). 2012;113:184-91 pubmed publisher
    b>Angiotensin II (Ang II) promotes vascular disease through several mechanisms including by producing oxidative stress and endothelial dysfunction...
  24. Tan Y, Li X, Prabhu S, Brittian K, Chen Q, Yin X, et al. Angiotensin II plays a critical role in alcohol-induced cardiac nitrative damage, cell death, remodeling, and cardiomyopathy in a protein kinase C/nicotinamide adenine dinucleotide phosphate oxidase-dependent manner. J Am Coll Cardiol. 2012;59:1477-86 pubmed publisher
    ..Furthermore, alcohol exposure significantly increased the expression of angiotensin II and its type 1 receptor (AT1)...
  25. Tao H, Rui C, Zheng J, Tang J, Wu L, Shi A, et al. Angiotensin II-mediated vascular changes in aged offspring rats exposed to perinatal nicotine. Peptides. 2013;44:111-9 pubmed publisher
    ..and plasma adrenocorticotropic hormone level; however, it significantly reduced plasma angiotensin I and angiotensin II in both sexes. Systolic pressure in the male aged PN offspring was significantly higher...
  26. Martin R, Miana M, Jurado López R, Martínez Martínez E, Gómez Hurtado N, Delgado C, et al. DIOL triterpenes block profibrotic effects of angiotensin II and protect from cardiac hypertrophy. PLoS ONE. 2012;7:e41545 pubmed publisher
    ..b>Angiotensin II is a well-known profibrotic and proliferative agent that participates in the cardiac remodeling associated ..
  27. Ishibashi Y, Matsui T, Ojima A, Nishino Y, Nakashima S, Maeda S, et al. Glucagon-like peptide-1 inhibits angiotensin II-induced mesangial cell damage via protein kinase A. Microvasc Res. 2012;84:395-8 pubmed publisher
    ..However, effects of GLP-1 on angiotensin II-exposed mesangial cells are unknown...
  28. Rodrigues Ferreira S, Abdelkarim M, Dillenburg Pilla P, Luissint A, Di Tommaso A, Deshayes F, et al. Angiotensin II facilitates breast cancer cell migration and metastasis. PLoS ONE. 2012;7:e35667 pubmed publisher
    ..In this study, we investigated whether angiotensin II, a major vasoactive peptide both produced locally and released in the bloodstream, may trigger activating ..
  29. Zhao H, Li M, Wang L, Su Y, Fang H, Lin J, et al. Angiotensin II induces TSLP via an AT1 receptor/NF-KappaB pathway, promoting Th17 differentiation. Cell Physiol Biochem. 2012;30:1383-97 pubmed publisher
    ..We measured the expression of TSLP in primary rat vascular smooth muscle cells (VSMCs) exposed to angiotensin II (Ang II) and evaluated the capacity of TSLP induced by Ang II to induce the differentiation of Th17 Cells...
  30. Rezk B, Yoshida T, Semprun Prieto L, Higashi Y, Sukhanov S, Delafontaine P. Angiotensin II infusion induces marked diaphragmatic skeletal muscle atrophy. PLoS ONE. 2012;7:e30276 pubmed publisher
    Advanced congestive heart failure (CHF) and chronic kidney disease (CKD) are characterized by increased angiotensin II (Ang II) levels and are often accompanied by significant skeletal muscle wasting that negatively impacts mortality and ..
  31. Lv P, Miao S, Shu Y, Dong L, Liu G, Xie X, et al. Phosphorylation of smooth muscle 22? facilitates angiotensin II-induced ROS production via activation of the PKC?-P47phox axis through release of PKC? and actin dynamics and is associated with hypertrophy and hyperplasia of vascular smooth muscle cel. Circ Res. 2012;111:697-707 pubmed publisher
    ..However, the mechanisms by which SM22? controls ROS production have not been characterized...
  32. Liu K, Deng X, Gong L, Chen X, Wang S, Chen H, et al. The effect of intermedin on angiotensin II and endothelin-1 induced ventricular myocyte hypertrophy in neonatal rat. Clin Lab. 2013;59:589-96 pubmed
    ..The aim of the study is to explore the effect of IMD on angiotensin II (Ang II) and endothelin-1 (ET-1) induced hypertrophy in ventricular myocytes of neonatal rat and to try to ..
  33. Grobe N, Weir N, Leiva O, Ong F, Bernstein K, Schmaier A, et al. Identification of prolyl carboxypeptidase as an alternative enzyme for processing of renal angiotensin II using mass spectrometry. Am J Physiol Cell Physiol. 2013;304:C945-53 pubmed publisher
    ..Elucidation of ACE2-independent ANG-(1-7) production pathways may have clinically important implications in patients with metabolic and renal disease. ..
  34. Qin Y, Cao X, Guo J, Zhang Y, Pan L, Zhang H, et al. Deficiency of cathepsin S attenuates angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-deficient mice. Cardiovasc Res. 2012;96:401-10 pubmed publisher
    ..Apoe(-/-)Ctss(-/-)) mice and in ApoE-deficient Cat S wild-type littermates (Apoe(-/-)Ctss(+/+)) by chronic angiotensin II infusion, and AAA lesions were analysed after 28 days...
  35. Okui S, Yamamoto H, Li W, Gamachi N, Fujita Y, Kashiwamura S, et al. Cisplatin-induced acute renal failure in mice is mediated by chymase-activated angiotensin-aldosterone system and interleukin-18. Eur J Pharmacol. 2012;685:149-55 pubmed publisher
    ..Cisplatin increased serum levels of aldosterone and angiotensin II in WT mice, but only angiotensin II levels in IL-18 KO mice...
  36. Lee H, Ham S, Kim M, Kim J, Paek K, Kang E, et al. Activation of PPAR? counteracts angiotensin II-induced ROS generation by inhibiting rac1 translocation in vascular smooth muscle cells. Free Radic Res. 2012;46:912-9 pubmed publisher
    b>Angiotensin II (Ang II)-mediated modification of the redox milieu of vascular smooth muscle cells (VSMCs) has been implicated in several pathophysiological processes, including cell proliferation, migration and differentiation...
  37. Jia G, Stormont R, Gangahar D, Agrawal D. Role of matrix Gla protein in angiotensin II-induced exacerbation of vascular calcification. Am J Physiol Heart Circ Physiol. 2012;303:H523-32 pubmed publisher
    ..b>Angiotensin II (ANG II) plays a crucial role in the atherogenic process through not only its pressor responses but also its ..
  38. Castañeda Bueno M, Cervantes Pérez L, Vazquez N, Uribe N, Kantesaria S, Morla L, et al. Activation of the renal Na+:Cl- cotransporter by angiotensin II is a WNK4-dependent process. Proc Natl Acad Sci U S A. 2012;109:7929-34 pubmed publisher
    ..depletion (promotion of salt reabsorption without K(+) secretion), a condition that is associated with high angiotensin II (AngII) levels, it has been proposed that AngII signaling might affect WNK4 modulation of the NCC...
  39. Li L, Zhang Z, Lei H, Wang C, Wu L, Wang J, et al. Angiotensin II reduces cardiac AdipoR1 expression through AT1 receptor/ROS/ERK1/2/c-Myc pathway. PLoS ONE. 2013;8:e49915 pubmed publisher
    ..Here, we investigated the effect of angiotensin II (AngII) on cardiac AdipoRs expression and explored the possible molecular mechanism...
  40. Jin H, Song B, Oudit G, Davidge S, Yu H, Jiang Y, et al. ACE2 deficiency enhances angiotensin II-mediated aortic profilin-1 expression, inflammation and peroxynitrite production. PLoS ONE. 2012;7:e38502 pubmed publisher
  41. Fazeli G, Stopper H, Schinzel R, Ni C, Jo H, Schupp N. Angiotensin II induces DNA damage via AT1 receptor and NADPH oxidase isoform Nox4. Mutagenesis. 2012;27:673-81 pubmed publisher
    ..in renal cells, and ex vivo, in the isolated perfused mouse kidney, we could show DNA-damaging potential of angiotensin II (Ang II). Here, the pathway involved in the genotoxicity of Ang II was investigated...
  42. Gonzalez A, Luffman C, Bourgeois C, Vio C, Prieto M. Angiotensin II-independent upregulation of cyclooxygenase-2 by activation of the (Pro)renin receptor in rat renal inner medullary cells. Hypertension. 2013;61:443-9 pubmed publisher
    ..cyclooxygenase-2 (COX-2)-derived prostaglandins attenuate the pressor and antinatriuretic effects of angiotensin II (AngII) in the renal medulla...
  43. Nguyen Dinh Cat A, Montezano A, Burger D, Touyz R. Angiotensin II, NADPH oxidase, and redox signaling in the vasculature. Antioxid Redox Signal. 2013;19:1110-20 pubmed publisher
    b>Angiotensin II (Ang II) influences the function of many cell types and regulates many organ systems, in large part through redox-sensitive processes...
  44. Westermann D, Becher P, Lindner D, Savvatis K, Xia Y, Fröhlich M, et al. Selective PDE5A inhibition with sildenafil rescues left ventricular dysfunction, inflammatory immune response and cardiac remodeling in angiotensin II-induced heart failure in vivo. Basic Res Cardiol. 2012;107:308 pubmed publisher
    ..PDE5A inhibition with sildenafil may provide a new treatment strategy for cardiac hypertrophy and adverse remodeling in the hypertensive heart. ..
  45. Zhang L, Xiong X, Fan Z, Gan X, Gao X, Zhu G. Involvement of enhanced cardiac sympathetic afferent reflex in sympathetic activation in early stage of diabetes. J Appl Physiol (1985). 2012;113:47-55 pubmed publisher
    ..Sympathetic activity and CSAR were enhanced in diabetic rats. Plasma norepinephrine and angiotensin II were increased, but the transient receptor potential vanilloid 1 (TRPV1) in the left ventricle wall was not ..
  46. Szekeres M, Nadasy G, Turu G, Soltész Katona E, Toth Z, Balla A, et al. Angiotensin II induces vascular endocannabinoid release, which attenuates its vasoconstrictor effect via CB1 cannabinoid receptors. J Biol Chem. 2012;287:31540-50 pubmed publisher
    In the vascular system angiotensin II (Ang II) causes vasoconstriction via the activation of type 1 angiotensin receptors...
  47. Dragun D. The detection of antibodies to the Angiotensin II-type 1 receptor in transplantation. Methods Mol Biol. 2013;1034:331-3 pubmed publisher
    ..Antibodies directed against the heart and kidney Angiotensin II type 1 receptor (AT1R) play a major role in antibody mediated rejection after heart and kidney transplantation ..
  48. Durand M, Lombard J. Low-dose angiotensin II infusion restores vascular function in cerebral arteries of high salt-fed rats by increasing copper/zinc superoxide dimutase expression. Am J Hypertens. 2013;26:739-47 pubmed publisher
    This study examined the vasoprotective role of circulating angiotensin II (ANG II) levels in the cerebral circulation of high salt (HS)-fed (SS...
  49. Hayashi W, Obata Y, Nishino T, Abe S, Io K, Furusu A, et al. Glomerular repair retardation via blocking of angiotensin II type 1a receptor pathway in a mouse glomerulonephritis model. Nephron Exp Nephrol. 2012;122:13-22 pubmed publisher
    To examine the role of the angiotensin II (ATII) type 1a receptor (AT1-R) pathway in renal tissue damage and repair, we investigated reversible glomerular injury in a mouse model of habu snake venom (HSV)-induced glomerulonephritis using ..
  50. Zhang X, Thatcher S, Rateri D, Bruemmer D, Charnigo R, Daugherty A, et al. Transient exposure of neonatal female mice to testosterone abrogates the sexual dimorphism of abdominal aortic aneurysms. Circ Res. 2012;110:e73-85 pubmed publisher
    ..Similarly, AAAs induced by angiotensin II (AngII) infusion into mice exhibit a higher prevalence in males...
  51. Fu X, Yamawaki Ogata A, Oshima H, Ueda Y, Usui A, Narita Y. Intravenous administration of mesenchymal stem cells prevents angiotensin II-induced aortic aneurysm formation in apolipoprotein E-deficient mouse. J Transl Med. 2013;11:175 pubmed publisher
    ..that intra-abdominal implantation of bone marrow-derived MSCs (BM-MSCs) sheet by laparotomy attenuated angiotensin II (AngII)-induced aortic aneurysm (AA) growth in apolipoprotein E-deficient (apoE-/-) mice through anti-..
  52. Abraham F, Sacerdoti F, De León R, Gentile T, Canellada A. Angiotensin II activates the calcineurin/NFAT signaling pathway and induces cyclooxygenase-2 expression in rat endometrial stromal cells. PLoS ONE. 2012;7:e37750 pubmed publisher
    ..b>Angiotensin II increases intracellular Ca(2+) concentration by targeting phospholypase C-gamma in endometrial stromal cells (..
  53. Zeng S, Chen X, Chen S, Li Q, Wang Y, Zou J, et al. Upregulation of Nox4 promotes angiotensin II-induced epidermal growth factor receptor activation and subsequent cardiac hypertrophy by increasing ADAM17 expression. Can J Cardiol. 2013;29:1310-9 pubmed publisher
    Activation of epidermal growth factor receptor (EGFR) plays an important role in angiotensin II (Ang II)-induced cardiac hypertrophy, but little is known about the underlying mechanism that results in EGFR activation...
  54. Kilarkaje N, Yousif M, El Hashim A, Makki B, Akhtar S, Benter I. Role of angiotensin II and angiotensin-(1-7) in diabetes-induced oxidative DNA damage in the corpus cavernosum. Fertil Steril. 2013;100:226-33 pubmed publisher
    ..Thus, Ang-(1-7)/MAS1 axis may be a novel therapeutic target for erectile dysfunction in DM. ..
  55. Jiang L, Xu L, Song Y, Li J, Mao J, Zhao A, et al. Calmodulin-dependent protein kinase II/cAMP response element-binding protein/Wnt/?-catenin signaling cascade regulates angiotensin II-induced podocyte injury and albuminuria. J Biol Chem. 2013;288:23368-79 pubmed publisher
    b>Angiotensin II (Ang II) plays a pivotal role in promoting podocyte dysfunction and albuminuria, however, the underlying mechanisms have not been fully delineated...
  56. Ozasa Y, Akazawa H, Qin Y, Tateno K, Ito K, Kudo Sakamoto Y, et al. Notch activation mediates angiotensin II-induced vascular remodeling by promoting the proliferation and migration of vascular smooth muscle cells. Hypertens Res. 2013;36:859-65 pubmed publisher
    ..These findings suggest that the hierarchical Ang II receptor-Notch signaling pathway promotes the proliferation and migration of VSMCs, and thereby contributes to the progression of vascular remodeling. ..
  57. Peng H, Li W, Seth D, Nair A, Francis J, Feng Y. (Pro)renin receptor mediates both angiotensin II-dependent and -independent oxidative stress in neuronal cells. PLoS ONE. 2013;8:e58339 pubmed publisher
    ..In conclusion, human PRR over-expression induced ROS production through both angiotensin II-dependent and -independent mechanisms...
  58. Chen J, Chen J, Harris R. Angiotensin II induces epithelial-to-mesenchymal transition in renal epithelial cells through reactive oxygen species/Src/caveolin-mediated activation of an epidermal growth factor receptor-extracellular signal-regulated kinase signaling pathway. Mol Cell Biol. 2012;32:981-91 pubmed publisher
    ..Here we report that in the proximal tubule-like LLCPKcl4 cells expressing angiotensin II (Ang II) type 1 receptor, Ang II induced changes in cell morphology and expression of epithelial-to-..
  59. Gu J, Liu X, Wang Q, Tan H, Guo M, Jiang W, et al. Angiotensin II increases CTGF expression via MAPKs/TGF-?1/TRAF6 pathway in atrial fibroblasts. Exp Cell Res. 2012;318:2105-15 pubmed publisher
    ..signaling pathway and increased expression of connective tissue growth factor (CTGF) induced by angiotensin II (AngII) have been proposed as a mechanism for atrial fibrosis...
  60. Salgado D, Favory R, Rocco J, Silva E, Ortiz J, Donadello K, et al. Microcirculatory effects of angiotensin II inhibitors in patients with severe heart failure. Clin Hemorheol Microcirc. 2013;54:87-98 pubmed publisher
    The renin-angiotensin system is activated in patients with acute severe heart failure, and increased levels of angiotensin II could contribute to microcirculatory defects in these patients...
  61. Matsusaka T, Niimura F, Shimizu A, Pastan I, Saito A, Kobori H, et al. Liver angiotensinogen is the primary source of renal angiotensin II. J Am Soc Nephrol. 2012;23:1181-9 pubmed publisher
    b>Angiotensin II content in the kidney is much higher than in the plasma, and it increases more in kidney diseases through an uncertain mechanism...
  62. Domińska K, Piastowska Ciesielska A, Lachowicz Ochedalska A, Ochedalski T. Similarities and differences between effects of angiotensin III and angiotensin II on human prostate cancer cell migration and proliferation. Peptides. 2012;37:200-6 pubmed publisher
    ..Assume also that Ang II can enhance the migration tendency aggressive prostate cancer cells, while Ang III does so more effective in non-metastatic cells. ..
  63. Massey K, Hong N, Garvin J. Angiotensin II stimulates superoxide production in the thick ascending limb by activating NOX4. Am J Physiol Cell Physiol. 2012;303:C781-9 pubmed publisher
    b>Angiotensin II (ANG II) stimulates production of superoxide (O(2)(-)) by NADPH oxidase (NOX) in medullary thick ascending limbs (TALs). There are three isoforms of the catalytic subunit (NOX1, 2, and 4) known to be expressed in the kidney...
  64. Song B, Jin H, Yu X, Zhang Z, Yu H, Ye J, et al. Angiotensin-converting enzyme 2 attenuates oxidative stress and VSMC proliferation via the JAK2/STAT3/SOCS3 and profilin-1/MAPK signaling pathways. Regul Pept. 2013;185:44-51 pubmed publisher
    ..ACE2 may represent a potential candidate to prevent and treat vascular disorders. ..
  65. Matsuda M, Tamura K, Wakui H, Maeda A, Ohsawa M, Kanaoka T, et al. Upstream stimulatory factors 1 and 2 mediate the transcription of angiotensin II binding and inhibitory protein. J Biol Chem. 2013;288:19238-49 pubmed publisher
    The angiotensin II type 1 receptor (AT1R)-associated protein (ATRAP/Agtrap) promotes constitutive internalization of the AT1R so as to specifically inhibit the pathological activation of its downstream signaling yet preserve the base-line ..
  66. Luft F, Dechend R, Muller D. Immune mechanisms in angiotensin II-induced target-organ damage. Ann Med. 2012;44 Suppl 1:S49-54 pubmed publisher
    ..Neural mechanisms interact with and regulate these processes. Understanding the mechanisms could direct us to novel therapies. ..
  67. Rands V, Seth D, Kobori H, Prieto M. Sexual dimorphism in urinary angiotensinogen excretion during chronic angiotensin II-salt hypertension. Gend Med. 2012;9:207-18 pubmed publisher
    ..is a sex difference in the intrarenal gene expression and urinary excretion of angiotensinogen (AGT) during angiotensin II (Ang II)-dependent hypertension and high-salt (HS) diet...
  68. Ashek A, Menzies R, Mullins L, Bellamy C, Harmar A, Kenyon C, et al. Activation of thiazide-sensitive co-transport by angiotensin II in the cyp1a1-Ren2 hypertensive rat. PLoS ONE. 2012;7:e36311 pubmed publisher
    ..This study finds activation of sodium-chloride co-transport to be a key mechanism in angiotensin II-dependent hypertension...
  69. Ishizuka T, Goshima H, Ozawa A, Watanabe Y. Effect of angiotensin II on proliferation and differentiation of mouse induced pluripotent stem cells into mesodermal progenitor cells. Biochem Biophys Res Commun. 2012;420:148-55 pubmed publisher
    ..Stimulation with angiotensin II (Ang II) significantly increased DNA synthesis in mouse iPS cells cultured in a medium with leukemia ..
  70. Seto S, Krishna S, Yu H, Liu D, Khosla S, Golledge J. Impaired acetylcholine-induced endothelium-dependent aortic relaxation by caveolin-1 in angiotensin II-infused apolipoprotein-E (ApoE-/-) knockout mice. PLoS ONE. 2013;8:e58481 pubmed publisher
    The angiotensin II (AngII)-infused apolipoprotein E-deficient (ApoE(-/-)) mouse model is widely used to study atherosclerosis and abdominal aortic aneurysm...
  71. Deji N, Kume S, Araki S, Isshiki K, Araki H, Chin Kanasaki M, et al. Role of angiotensin II-mediated AMPK inactivation on obesity-related salt-sensitive hypertension. Biochem Biophys Res Commun. 2012;418:559-64 pubmed publisher
    ..b>Angiotensin II (AII) is a key peptide underlying sodium retention...
  72. Sriramula S, Cardinale J, Francis J. Inhibition of TNF in the brain reverses alterations in RAS components and attenuates angiotensin II-induced hypertension. PLoS ONE. 2013;8:e63847 pubmed publisher
  73. Modgil A, Zhang Q, Pingili A, Singh N, Yao F, Ge J, et al. Angiotensin-(1-7) attenuates the chronotropic response to angiotensin II via stimulation of PTEN in the spontaneously hypertensive rat neurons. Am J Physiol Heart Circ Physiol. 2012;302:H1116-22 pubmed publisher
    ..in the regulation of cardiovascular function, showing its counterregulatory effect against the actions of angiotensin II (ANG II). However, its actions in the central nervous system are not completely understood...
  74. Wang S, Han H, Pan Z, Hang P, Sun L, Jiang Y, et al. Choline inhibits angiotensin II-induced cardiac hypertrophy by intracellular calcium signal and p38 MAPK pathway. Naunyn Schmiedebergs Arch Pharmacol. 2012;385:823-31 pubmed publisher
    ..present study was therefore designed to explore whether choline could prevent cardiac hypertrophy induced by angiotensin II (Ang II) and clarify its potential mechanisms. Cardiac hypertrophy was induced by 0...
  75. Haack K, Engler C, Papoutsi E, Pipinos I, Patel K, Zucker I. Parallel changes in neuronal AT1R and GRK5 expression following exercise training in heart failure. Hypertension. 2012;60:354-61 pubmed publisher
    ..The angiotensin II type 1 receptor (AT1R) plays a pivotal role in the development of CHF and is upregulated in a number of ..
  76. Basu R, Fan D, Kandalam V, Lee J, Das S, Wang X, et al. Loss of Timp3 gene leads to abdominal aortic aneurysm formation in response to angiotensin II. J Biol Chem. 2012;287:44083-96 pubmed publisher
    ..We investigated the causal role of Timp3 in AAA formation. Infusion of angiotensin II (Ang II) using micro-osmotic (Alzet) pumps in Timp3(-/-) male mice, but not in wild type control mice, led to ..
  77. Monasky M, Taglieri D, Henze M, Warren C, Utter M, Soergel D, et al. The ?-arrestin-biased ligand TRV120023 inhibits angiotensin II-induced cardiac hypertrophy while preserving enhanced myofilament response to calcium. Am J Physiol Heart Circ Physiol. 2013;305:H856-66 pubmed publisher
    In the present study, we compared the cardioprotective effects of TRV120023, a novel angiotensin II (ANG II) type 1 receptor (AT1R) ligand, which blocks G protein coupling but stimulates ?-arrestin signaling, against treatment with ..
  78. Morinelli T, Lee M, Kendall R, Luttrell L, Walker L, Ullian M. Angiotensin II activates NF-?B through AT1A receptor recruitment of ?-arrestin in cultured rat vascular smooth muscle cells. Am J Physiol Cell Physiol. 2013;304:C1176-86 pubmed publisher
  79. Sun L, Wang W, Xiao W, Liang H, Yang Y, Yang H. Angiotensin II induces apoptosis in intestinal epithelial cells through the AT2 receptor, GATA-6 and the Bax pathway. Biochem Biophys Res Commun. 2012;424:663-8 pubmed publisher
    b>Angiotensin II (Ang II) has been shown to play an important role in cell apoptosis. However, the mechanisms of Ang-II-induced apoptosis in intestinal epithelial cells are not fully understood...
  80. Mann M, Exner D, Hemmelgarn B, Turin T, Sola D, Ahmed S. Impact of gender on the cardiac autonomic response to angiotensin II in healthy humans. J Appl Physiol (1985). 2012;112:1001-7 pubmed publisher
    ..We examined the cardiac ANS response to angiotensin II (Ang II) challenge in healthy subjects to determine whether differences in women and men exist...
  81. Wilkinson Berka J, Agrotis A, Deliyanti D. The retinal renin-angiotensin system: roles of angiotensin II and aldosterone. Peptides. 2012;36:142-50 pubmed publisher
    ..contribution of specific components of the renin-angiotensin system is evaluated with a particular focus on angiotensin II and aldosterone and their cognate receptors...
  82. Ong F, Lin C, Campbell D, Okwan Duodu D, Chen X, Blackwell W, et al. Increased angiotensin II-induced hypertension and inflammatory cytokines in mice lacking angiotensin-converting enzyme N domain activity. Hypertension. 2012;59:283-90 pubmed publisher
    ..response, N-knockout (KO) and C-KO mice, models lacking 1 of the 2 ACE domains, were analyzed during angiotensin II-induced hypertension. At 2 weeks, N-KO mice have systolic blood pressures that averaged 173±4...