factor xiii

Summary

Summary: A fibrin-stabilizing plasma enzyme (TRANSGLUTAMINASES) that is activated by THROMBIN and CALCIUM to form FACTOR XIIIA. It is important for stabilizing the formation of the fibrin polymer (clot) which culminates the coagulation cascade.

Top Publications

  1. Gerardino L, Papaleo P, Flex A, Gaetani E, Fioroni G, Pola P, et al. Coagulation factor XIII Val34Leu gene polymorphism and Alzheimer's disease. Neurol Res. 2006;28:807-9 pubmed
    Blood coagulation factor XIII (FXIII) plays a role in inflammatory processes and a pathogenetic role of inflammation in neurodegenerative disorders has been proposed...
  2. Levy J, Gill R, Nussmeier N, Olsen P, Andersen H, Booth F, et al. Repletion of factor XIII following cardiopulmonary bypass using a recombinant A-subunit homodimer. A preliminary report. Thromb Haemost. 2009;102:765-71 pubmed publisher
    Bleeding following cardiac surgery involving cardiopulmonary bypass (CPB) remains a major concern. Coagulation factor XIII (FXIII) functions as a clot-stabilising factor by cross-linking fibrin...
  3. Shin J, Lee J. Severe gastrointestinal vasculitis in Henoch-Schoenlein purpura: pathophysiologic mechanisms, the diagnostic value of factor XIII, and therapeutic options. Eur J Pediatr. 2007;166:1199-200; author reply 1201 pubmed
  4. Dossenbach Glaninger A, van Trotsenburg M, Dossenbach M, Oberkanins C, Moritz A, Krugluger W, et al. Plasminogen activator inhibitor 1 4G/5G polymorphism and coagulation factor XIII Val34Leu polymorphism: impaired fibrinolysis and early pregnancy loss. Clin Chem. 2003;49:1081-6 pubmed
    ..Two polymorphisms, coagulation factor XIII (FXIII) Val34Leu and plasminogen activator inhibitor 1 (PAI-1) 4G/5G, interfere with fibrin cross-linking and ..
  5. Dirkmann D, Görlinger K, Gisbertz C, Dusse F, Peters J. Factor XIII and tranexamic acid but not recombinant factor VIIa attenuate tissue plasminogen activator-induced hyperfibrinolysis in human whole blood. Anesth Analg. 2012;114:1182-8 pubmed publisher
    ..b>Factor XIII (FXIII) and thrombin activatable fibrinolysis inhibitor have key roles in protecting clots against fibrinolysis...
  6. Loof T, Morgelin M, Johansson L, Oehmcke S, Olin A, Dickneite G, et al. Coagulation, an ancestral serine protease cascade, exerts a novel function in early immune defense. Blood. 2011;118:2589-98 pubmed publisher
    ..The entrapment is mediated via cross-linking of bacteria to fibrin fibers by the action of coagulation factor XIII (fXIII), an evolutionarily conserved transglutaminase...
  7. Kwon M, Kong D, Jung S, Suh I, Kim Y, Ha K. Rapid determination of blood coagulation factor XIII activity using protein arrays for serodiagnosis of human plasma. Anal Chem. 2011;83:2317-23 pubmed publisher
    We developed a novel on-chip assay using protein arrays for quantitative and rapid analysis of blood coagulation factor XIII (FXIII) activity in human plasma...
  8. Slowik A, Dziedzic T, Pera J, Figlewicz D, Szczudlik A. Coagulation factor XIII VaI34Leu polymorphism in patients with small vessel disease or primary intracerebral hemorrhage. Cerebrovasc Dis. 2005;19:165-70 pubmed
    ..1-3.9). The genotype distribution did not differ significantly between PICH patients and their controls (50 vs. 43%). Our results suggest that the Val/Val genotype of FXIII could be associated with an increased risk of SVD stroke. ..
  9. Orosz Z, Katona E, Facsko A, Modis L, Muszbek L, Berta A. Factor XIII subunits in human tears; their highly elevated levels following penetrating keratoplasty. Clin Chim Acta. 2011;412:271-6 pubmed publisher
    As blood coagulation factor XIII (FXIII) is of high importance in wound healing, we determined the concentrations of FXIII A and B subunits (FXIII-A and FXIII-B) and their complex (FXIII-A(2)B(2)) in normal tears and in tears from ..
  10. Dardik R, Loscalzo J, Inbal A. Factor XIII (FXIII) and angiogenesis. J Thromb Haemost. 2006;4:19-25 pubmed
    b>Factor XIII is a plasma transglutaminase that participates in the final stage of the coagulation cascade...

Detail Information

Publications62

  1. Gerardino L, Papaleo P, Flex A, Gaetani E, Fioroni G, Pola P, et al. Coagulation factor XIII Val34Leu gene polymorphism and Alzheimer's disease. Neurol Res. 2006;28:807-9 pubmed
    Blood coagulation factor XIII (FXIII) plays a role in inflammatory processes and a pathogenetic role of inflammation in neurodegenerative disorders has been proposed...
  2. Levy J, Gill R, Nussmeier N, Olsen P, Andersen H, Booth F, et al. Repletion of factor XIII following cardiopulmonary bypass using a recombinant A-subunit homodimer. A preliminary report. Thromb Haemost. 2009;102:765-71 pubmed publisher
    Bleeding following cardiac surgery involving cardiopulmonary bypass (CPB) remains a major concern. Coagulation factor XIII (FXIII) functions as a clot-stabilising factor by cross-linking fibrin...
  3. Shin J, Lee J. Severe gastrointestinal vasculitis in Henoch-Schoenlein purpura: pathophysiologic mechanisms, the diagnostic value of factor XIII, and therapeutic options. Eur J Pediatr. 2007;166:1199-200; author reply 1201 pubmed
  4. Dossenbach Glaninger A, van Trotsenburg M, Dossenbach M, Oberkanins C, Moritz A, Krugluger W, et al. Plasminogen activator inhibitor 1 4G/5G polymorphism and coagulation factor XIII Val34Leu polymorphism: impaired fibrinolysis and early pregnancy loss. Clin Chem. 2003;49:1081-6 pubmed
    ..Two polymorphisms, coagulation factor XIII (FXIII) Val34Leu and plasminogen activator inhibitor 1 (PAI-1) 4G/5G, interfere with fibrin cross-linking and ..
  5. Dirkmann D, Görlinger K, Gisbertz C, Dusse F, Peters J. Factor XIII and tranexamic acid but not recombinant factor VIIa attenuate tissue plasminogen activator-induced hyperfibrinolysis in human whole blood. Anesth Analg. 2012;114:1182-8 pubmed publisher
    ..b>Factor XIII (FXIII) and thrombin activatable fibrinolysis inhibitor have key roles in protecting clots against fibrinolysis...
  6. Loof T, Morgelin M, Johansson L, Oehmcke S, Olin A, Dickneite G, et al. Coagulation, an ancestral serine protease cascade, exerts a novel function in early immune defense. Blood. 2011;118:2589-98 pubmed publisher
    ..The entrapment is mediated via cross-linking of bacteria to fibrin fibers by the action of coagulation factor XIII (fXIII), an evolutionarily conserved transglutaminase...
  7. Kwon M, Kong D, Jung S, Suh I, Kim Y, Ha K. Rapid determination of blood coagulation factor XIII activity using protein arrays for serodiagnosis of human plasma. Anal Chem. 2011;83:2317-23 pubmed publisher
    We developed a novel on-chip assay using protein arrays for quantitative and rapid analysis of blood coagulation factor XIII (FXIII) activity in human plasma...
  8. Slowik A, Dziedzic T, Pera J, Figlewicz D, Szczudlik A. Coagulation factor XIII VaI34Leu polymorphism in patients with small vessel disease or primary intracerebral hemorrhage. Cerebrovasc Dis. 2005;19:165-70 pubmed
    ..1-3.9). The genotype distribution did not differ significantly between PICH patients and their controls (50 vs. 43%). Our results suggest that the Val/Val genotype of FXIII could be associated with an increased risk of SVD stroke. ..
  9. Orosz Z, Katona E, Facsko A, Modis L, Muszbek L, Berta A. Factor XIII subunits in human tears; their highly elevated levels following penetrating keratoplasty. Clin Chim Acta. 2011;412:271-6 pubmed publisher
    As blood coagulation factor XIII (FXIII) is of high importance in wound healing, we determined the concentrations of FXIII A and B subunits (FXIII-A and FXIII-B) and their complex (FXIII-A(2)B(2)) in normal tears and in tears from ..
  10. Dardik R, Loscalzo J, Inbal A. Factor XIII (FXIII) and angiogenesis. J Thromb Haemost. 2006;4:19-25 pubmed
    b>Factor XIII is a plasma transglutaminase that participates in the final stage of the coagulation cascade...
  11. Palumbo J, Barney K, Blevins E, Shaw M, Mishra A, Flick M, et al. Factor XIII transglutaminase supports hematogenous tumor cell metastasis through a mechanism dependent on natural killer cell function. J Thromb Haemost. 2008;6:812-9 pubmed publisher
    ..b>Factor XIII is a significant determinant of metastatic potential and supports metastasis by impeding NK cell-mediated ..
  12. Albanese A, Tuttolomondo A, Anile C, Sabatino G, Pompucci A, Pinto A, et al. Spontaneous chronic subdural hematomas in young adults with a deficiency in coagulation factor XIII. Report of three cases. J Neurosurg. 2005;102:1130-2 pubmed
    ..The authors report on three young men with a deficiency in coagulation factor XIII (FXIII) who underwent surgery for chronic SDHs...
  13. Schlimp C, Cadamuro J, Solomon C, Redl H, Schöchl H. The effect of fibrinogen concentrate and factor XIII on thromboelastometry in 33% diluted blood with albumin, gelatine, hydroxyethyl starch or saline in vitro. Blood Transfus. 2013;11:510-7 pubmed publisher
    Fluid replacement results in dilutional coagulopathy. We investigated the potential role of fibrinogen, factor XIII and a combination of both to reverse dilutional coagulopathy, assessed by thromboelastometry (ROTEM(®))...
  14. Kiss F, Simon A, Csathy L, Hevessy Z, Katona E, Kiss C, et al. A coagulation factor becomes useful in the study of acute leukemias: studies with blood coagulation factor XIII. Cytometry A. 2008;73:194-201 pubmed
    The intracellular form of the coagulation factor XIII has previously been identified by immunomorphological techniques using polyclonal antibodies...
  15. Pruissen D, Slooter A, Rosendaal F, van der Graaf Y, Algra A. Coagulation factor XIII gene variation, oral contraceptives, and risk of ischemic stroke. Blood. 2008;111:1282-6 pubmed
    ..A total of 4 variants of coagulation factor XIII subunit A and B genes (F13A1 and F13B) were investigated...
  16. Komanasin N, Catto A, Futers T, Van Hylckama Vlieg A, Rosendaal F, Ariens R. A novel polymorphism in the factor XIII B-subunit (His95Arg): relationship to subunit dissociation and venous thrombosis. J Thromb Haemost. 2005;3:2487-96 pubmed
    ..The Arg95 variant associates with a moderately increased risk for venous thrombosis, and with increased dissociation of the FXIII subunits in plasma, although in vitro steady-state binding between purified subunits was not affected. ..
  17. Muszbek L, Bagoly Z, Bereczky Z, Katona E. The involvement of blood coagulation factor XIII in fibrinolysis and thrombosis. Cardiovasc Hematol Agents Med Chem. 2008;6:190-205 pubmed
    It has been known for a long time that blood coagulation factor XIII (FXIII) is essential for maintaining haemostasis, its deficiency leads to severe bleeding complication...
  18. Ichinose A, Asahina T, Kobayashi T. Congenital blood coagulation factor XIII deficiency and perinatal management. Curr Drug Targets. 2005;6:541-9 pubmed
    ..b>Factor XIII (FXIII) is a plasma transglutaminase circulating in blood as a heterotetramer and consisting of two catalytic A ..
  19. de la Red G, Tàssies D, Espinosa G, Monteagudo J, Bove A, Plaza J, et al. Factor XIII-A subunit Val34Leu polymorphism is associated with the risk of thrombosis in patients with antiphospholipid antibodies and high fibrinogen levels. Thromb Haemost. 2009;101:312-6 pubmed
    Recent reports have described the factor XIII A subunit (FXIII-A) Val34Leu polymorphism as a protective factor against venous and arterial thrombosis...
  20. Katona E, Nagy B, Kappelmayer J, Baktai G, Kovacs L, Márialigeti T, et al. Factor XIII in bronchoalveolar lavage fluid from children with chronic bronchoalveolar inflammation. J Thromb Haemost. 2005;3:1407-13 pubmed
    ..The turnover of extravascular fibrin is attenuated by its cross-linking with activated factor XIII (FXIII)...
  21. Bereczky Z, Katona E, Muszbek L. Fibrin stabilization (factor XIII), fibrin structure and thrombosis. Pathophysiol Haemost Thromb. 2003;33:430-7 pubmed
    b>Factor XIII (FXIII) is a zymogen that is converted into an active transglutaminase (FXIIIa) by the concerted action of thrombin and Ca2+...
  22. Nielsen V, Gurley W, Burch T. The impact of factor XIII on coagulation kinetics and clot strength determined by thrombelastography. Anesth Analg. 2004;99:120-3 pubmed
    ..However, factor XIII (FXIII) activity also plays a prominent role in the development of clot strength...
  23. Souri M, Koseki Kuno S, Takeda N, Degen J, Ichinose A. Administration of factor XIII B subunit increased plasma factor XIII A subunit levels in factor XIII B subunit knock-out mice. Int J Hematol. 2008;87:60-8 pubmed publisher
    b>Factor XIII (FXIII) is a proenzyme of plasma transglutaminase consisting of enzymatic A (FXIII-A) and noncatalytic B subunits (FXIII-B), and acts in hemostasis and wound healing...
  24. Fraser S, Booth N, Mutch N. The antifibrinolytic function of factor XIII is exclusively expressed through ??-antiplasmin cross-linking. Blood. 2011;117:6371-4 pubmed publisher
    b>Factor XIII (FXIII) generates fibrin-fibrin and fibrin-inhibitor cross-links...
  25. Schroeder V, Durrer D, Meili E, Schubiger G, Kohler H. Congenital factor XIII deficiency in Switzerland: from the worldwide first case in 1960 to its molecular characterisation in 2005. Swiss Med Wkly. 2007;137:272-8 pubmed
    Coagulation factor XIII (FXIII) has a major role in the final stage of blood coagulation, is important for wound healing and maintaining pregnancy. Severe congenital FXIII deficiency is a rare disorder with 1 patient in 1-3 million...
  26. Dardik R, Solomon A, Loscalzo J, Eskaraev R, Bialik A, Goldberg I, et al. Novel proangiogenic effect of factor XIII associated with suppression of thrombospondin 1 expression. Arterioscler Thromb Vasc Biol. 2003;23:1472-7 pubmed
    b>Factor XIII (FXIII), a plasma transglutaminase that stabilizes fibrin clots at the final stages of blood coagulation by crosslinking fibrin monomers, is essential for embryo implantation and participates in tissue remodeling and wound ..
  27. Kiss F, Hevessy Z, Veszprémi A, Katona E, Kiss C, Vereb G, et al. Leukemic lymphoblasts, a novel expression site of coagulation factor XIII subunit A. Thromb Haemost. 2006;96:176-82 pubmed
    Blood coagulation factor XIII (FXIII) is a protransglutaminase circulating as a tetramer formed by two types of subunits (A2B2)...
  28. Adany R, Bardos H. Factor XIII subunit A as an intracellular transglutaminase. Cell Mol Life Sci. 2003;60:1049-60 pubmed
    Over the last 2 decades there has been increasing evidence that the role of factor XIII (FXIII) is not restricted to the area of hemostasis and that its subunit A functions as an intracellular enzyme in platelets and monocytes/..
  29. Nielsen V. Colloids decrease clot propagation and strength: role of factor XIII-fibrin polymer and thrombin-fibrinogen interactions. Acta Anaesthesiol Scand. 2005;49:1163-71 pubmed
    ..and diluted samples had either no additions or addition of fibrinogen (FI), thrombin (FIIa) or activated Factor XIII (FXIIIa) to restore protein function to prediluted values...
  30. Tacke F, Fiedler K, von Depka M, Luedde T, Hecker H, Manns M, et al. Clinical and prognostic role of plasma coagulation factor XIII activity for bleeding disorders and 6-year survival in patients with chronic liver disease. Liver Int. 2006;26:173-81 pubmed
    Alterations of plasma coagulation factor XIII may contribute to bleeding disorders in patients with liver cirrhosis...
  31. Lovejoy A, Reynolds T, Visich J, Butine M, Young G, Belvedere M, et al. Safety and pharmacokinetics of recombinant factor XIII-A2 administration in patients with congenital factor XIII deficiency. Blood. 2006;108:57-62 pubmed
    Congenital factor XIII (FXIII) deficiency is associated with a tendency for severe bleeding, a risk for spontaneous abortion, and a high rate of spontaneous intracranial hemorrhage...
  32. Song J, Choi J, Song K, Rhee J. Plasma factor XIII activity in patients with disseminated intravascular coagulation. Yonsei Med J. 2006;47:196-200 pubmed
    The objective of this study was to investigate the correlation between factor XIII (FXIII) activity and disseminated intravascular coagulation (DIC) parameters and also to evaluate the clinical usefulness of DIC diagnosis...
  33. Tung C, Ho N, Zeng Q, Tang Y, Jaffer F, Reed G, et al. Novel factor XIII probes for blood coagulation imaging. Chembiochem. 2003;4:897-9 pubmed
  34. Suchocki E, Brecher A. The effect of acetaldehyde on human plasma factor XIII function. Dig Dis Sci. 2007;52:3488-92 pubmed
    ..Factor XIIIa assay with fibrinogen and thrombin which had been preheated at 40 degrees C to destroy endogenous Factor XIII/XIIIa activity...
  35. Andersen M, Kjalke M, Bang S, Lautrup Larsen I, Becker P, Andersen A, et al. Coagulation factor XIII variants with altered thrombin activation rates. Biol Chem. 2009;390:1279-83 pubmed publisher
    Coagulation factor XIII (FXIII) is activated by thrombin and catalyses crosslinking between fibrin monomers thereby providing mechanical strength to the fibrin network...
  36. Raut S, Merton R, Rigsby P, Muszbek L, Seitz R, Ariens R, et al. A collaborative study to establish the 1st International Standard for factor XIII plasma. J Thromb Haemost. 2007;5:1923-9 pubmed
    ..auspices of the FXIII Standardization Working Party (SWP), to calibrate the 1st International Standard (IS) for factor XIII (FXIII) plasma...
  37. Birnbaum J, Hein O, Lührs C, Rückbeil O, Spies C, Ziemer S, et al. Effects of coagulation factor XIII on intestinal functional capillary density, leukocyte adherence and mesenteric plasma extravasation in experimental endotoxemia. Crit Care. 2006;10:R29 pubmed
    The objective of this study was to determine the effects of the administration of the coagulation factor XIII (F XIII) on intestinal functional capillary density, leukocyte adherence and mesenteric plasma extravasation during ..
  38. Blome M, Isgro F, Kiessling A, Skuras J, Haubelt H, Hellstern P, et al. Relationship between factor XIII activity, fibrinogen, haemostasis screening tests and postoperative bleeding in cardiopulmonary bypass surgery. Thromb Haemost. 2005;93:1101-7 pubmed
    We investigated the relationship between factor XIII, fibrinogen, blood coagulation screening tests and postoperative bleeding in 98 patients undergoing cardiopulmonary bypass (CPB) surgery. All patients received aprotinin...
  39. Muszbek L, Ariëns R, Ichinose A. Factor XIII: recommended terms and abbreviations. J Thromb Haemost. 2007;5:181-3 pubmed
  40. Hsieh L, Nugent D. Factor XIII deficiency. Haemophilia. 2008;14:1190-200 pubmed publisher
    Inherited factor XIII (FXIII) deficiency is a rare bleeding disorder that can present with umbilical bleeding during the neonatal period, delayed soft tissue bruising, mucosal bleeding and life-threatening intracranial haemorrhage...
  41. Ichinose A. Hemorrhagic acquired factor XIII (13) deficiency and acquired hemorrhaphilia 13 revisited. Semin Thromb Hemost. 2011;37:382-8 pubmed publisher
    Coagulation factor XIII (F13) circulates in blood as a heterotetramer composed of an A subunit dimer and a B subunit dimer. It is activated by thrombin and crosslinks fibrin monomers...
  42. Vossen C, Rosendaal F. The protective effect of the factor XIII Val34Leu mutation on the risk of deep venous thrombosis is dependent on the fibrinogen level. J Thromb Haemost. 2005;3:1102-3 pubmed
  43. Karimi M, Bereczky Z, Cohan N, Muszbek L. Factor XIII Deficiency. Semin Thromb Hemost. 2009;35:426-38 pubmed publisher
    b>Factor XIII (FXIII) is a tetrameric zymogen (FXIII-A (2)B (2)) that is converted into an active transglutaminase (FXIIIa) by thrombin and Ca (2+) in the terminal phase of the clotting cascade...
  44. Kawasaki K, Komura H, Nakahara Y, Shiraishi M, Higashida M, Ouchi K. Factor XIII in Henoch-Schönlein purpura with isolated gastrointestinal symptoms. Pediatr Int. 2006;48:413-5 pubmed
  45. Mosesson M, Siebenlist K, Hernandez I, Lee K, Christiansen V, McKee P. Evidence that alpha2-antiplasmin becomes covalently ligated to plasma fibrinogen in the circulation: a new role for plasma factor XIII in fibrinolysis regulation. J Thromb Haemost. 2008;6:1565-70 pubmed publisher
    ..It is well established that in the presence of thrombin-activated factor XIII (FXIIIa), alpha2AP becomes covalently ligated to the distal alpha chains of fibrin or fibrinogen at lysine 303 (..
  46. Vairaktaris E, Vassiliou S, Yapijakis C, Spyridonidou S, Vylliotis A, Derka S, et al. Increased risk for oral cancer is associated with coagulation factor XIII but not with factor XII. Oncol Rep. 2007;18:1537-43 pubmed
    ..Nevertheless, this thinner and less porous fibrin network inhibits cell migration. ..
  47. Ivaskevicius V, Seitz R, Kohler H, Schroeder V, Muszbek L, Ariens R, et al. International registry on factor XIII deficiency: a basis formed mostly on European data. Thromb Haemost. 2007;97:914-21 pubmed
    ..f13-database.de) will provide clinicians and scientists working on FXIII deficiency with a helpful tool to improve patient care and direct future studies towards better understanding and treatment of the disease. ..
  48. Wells P, Anderson J, Scarvelis D, Doucette S, Gagnon F. Factor XIII Val34Leu variant is protective against venous thromboembolism: a HuGE review and meta-analysis. Am J Epidemiol. 2006;164:101-9 pubmed
  49. Ajzner E, Schlammadinger A, Kerényi A, Bereczky Z, Katona E, Haramura G, et al. Severe bleeding complications caused by an autoantibody against the B subunit of plasma factor XIII: a novel form of acquired factor XIII deficiency. Blood. 2009;113:723-5 pubmed publisher
    Acquired factor XIII (FXIII) deficiency due to autoantibody against FXIII is a very rare severe hemorrhagic diathesis...
  50. Inbal A, Lubetsky A, Krapp T, Castel D, Shaish A, Dickneitte G, et al. Impaired wound healing in factor XIII deficient mice. Thromb Haemost. 2005;94:432-7 pubmed
    b>Factor XIII that stabilizes fibrin clots in the final stages of blood coagulation also participates in wound healing, as can be inferred from a delay in wound repair in some patients with inherited FXIII deficiency...
  51. Mannila M, Eriksson P, Ericsson C, Hamsten A, Silveira A. Epistatic and pleiotropic effects of polymorphisms in the fibrinogen and coagulation factor XIII genes on plasma fibrinogen concentration, fibrin gel structure and risk of myocardial infarction. Thromb Haemost. 2006;95:420-7 pubmed
    ..An intricate interplay between the genes encoding fibrinogen gamma (FGG), alpha (FGA) and beta (FGB), coagulation factor XIII (F13A1) and interleukin 6 (IL6) and environmental factors is likely to influence plasma fibrinogen ..
  52. Lawrie A, Green L, Mackie I, Liesner R, Machin S, Peyvandi F. Factor XIII--an under diagnosed deficiency--are we using the right assays?. J Thromb Haemost. 2010;8:2478-82 pubmed publisher
  53. Bereczky Z, Balogh E, Katona E, Pocsai Z, Czuriga I, Szeles G, et al. Modulation of the risk of coronary sclerosis/myocardial infarction by the interaction between factor XIII subunit A Val34Leu polymorphism and fibrinogen concentration in the high risk Hungarian population. Thromb Res. 2007;120:567-73 pubmed
    The results on the association of factor XIII (FXIII) A subunit (FXIII-A) Val34Leu polymorphism with the risk of myocardial infarction (MI) are rather inconclusive...
  54. Lak M, Peyvandi F, Ali Sharifian A, Karimi K, Mannucci P. Pattern of symptoms in 93 Iranian patients with severe factor XIII deficiency. J Thromb Haemost. 2003;1:1852-3 pubmed
  55. Lim B, Ariens R, Carter A, Weisel J, Grant P. Genetic regulation of fibrin structure and function: complex gene-environment interactions may modulate vascular risk. Lancet. 2003;361:1424-31 pubmed
    Polymorphisms in the fibrinogen and factor XIII genes are associated with atherothrombotic risk, but clinical studies have produced inconsistent results and laboratory studies have not explained these findings...
  56. Tiedje V, Dunkler D, Ay C, Horvath B, Quehenberger P, Pabinger M, et al. The role of fibrinogen plasma levels, the -455G>A fibrinogen and the factor XIII A subunit (FXIII-A) Val34Leu polymorphism in cancer-associated venous thrombosis. Thromb Haemost. 2011;106:908-13 pubmed publisher
    ..plasma levels, the -455G>A SNP in the fibrinogen beta gene and the Val34Leu (163G>T) SNP in the factor XIII A-subunit (FXIII-A) gene on the risk of VTE...
  57. Spannagl M, Joch C, Heindl B. [Safety of plasma-derived factor concentrates: an example of pharmacovigilance with fibrinogen and factor XIII-concentrate]. Hamostaseologie. 2006;26:S36-40 pubmed
    ..According to estimates, far less than half of occurring adverse events are registered in Germany. A European solution in the form of an official register is about to be introduced. ..
  58. Gosk Bierska I, McBane R, Wu Y, Mruk J, Tafur A, McLeod T, et al. Platelet factor XIII gene expression and embolic propensity in atrial fibrillation. Thromb Haemost. 2011;106:75-82 pubmed publisher
    ..Expression of six platelet-predominate genes: H2A histone family, A1 domain of factor XIII, integrin ??b??; glycoprotein IX, platelet factor 4, glycoprotein Ib, was performed using TaqMan MGB-probe ..
  59. Dardik R, Loscalzo J, Eskaraev R, Inbal A. Molecular mechanisms underlying the proangiogenic effect of factor XIII. Arterioscler Thromb Vasc Biol. 2005;25:526-32 pubmed
    Coagulation Factor XIII (FXIII) was previously shown by us to induce angiogenesis...
  60. Zaets S, Xu D, Lu Q, Feketova E, Berezina T, Malinina I, et al. Recombinant factor XIII mitigates hemorrhagic shock-induced organ dysfunction. J Surg Res. 2011;166:e135-42 pubmed publisher
    Plasma factor XIII (FXIII) is responsible for stabilization of fibrin clot at the final stage of blood coagulation...
  61. Ichinose A. Extracellular transglutaminase: factor XIII. Prog Exp Tumor Res. 2005;38:192-208 pubmed
  62. Hancer V, Diz Kucukkaya R, Bilge A, Ozben B, Oncul A, Ergen G, et al. The association between factor XIII Val34Leu polymorphism and early myocardial infarction. Circ J. 2006;70:239-42 pubmed
    Activated factor XIII (FXIII) cross-links between fibrin monomers, thus increasing the clot stability and resistance to fibrinolysis. Congenital FXIII deficiency causes severe bleeding diathesis...