factor x

Summary

Summary: Storage-stable glycoprotein blood coagulation factor that can be activated to factor Xa by both the intrinsic and extrinsic pathways. A deficiency of factor X, sometimes called Stuart-Prower factor deficiency, may lead to a systemic coagulation disorder.

Top Publications

  1. Doronin K, Flatt J, Di Paolo N, Khare R, Kalyuzhniy O, Acchione M, et al. Coagulation factor X activates innate immunity to human species C adenovirus. Science. 2012;338:795-8 pubmed publisher
    ..We modeled the interface of human species C adenovirus (HAdv) interaction with coagulation factor X (FX) and introduced a mutation that abrogated formation of the HAdv-FX complex...
  2. Leonardi A, Fox J, Trampus Bakija A, Krizaj I. Two coagulation factor X activators from Vipera a. ammodytes venom with potential to treat patients with dysfunctional factors IXa or VIIa. Toxicon. 2008;52:628-37 pubmed publisher
    Two activators of coagulation factor X, 58kDa VAFXA-I and 70kDa VAFXA-II, were purified from the venom of long-nosed viper (Vipera ammodytes ammodytes) by chromatography on gel filtration, affinity, ion-exchange and hydroxyapatite media...
  3. Erem C. Blood coagulation, fibrinolytic activity and lipid profile in subclinical thyroid disease: subclinical hyperthyroidism increases plasma factor X activity. Clin Endocrinol (Oxf). 2006;64:323-9 pubmed
    ..Increased factor X activity in patients with subclinical hyperthyroidism represent a potential hypercoagulable state, which might ..
  4. Kwong S, Woods A, Mirtschin P, Ge R, Kini R. The recruitment of blood coagulation factor X into snake venom gland as a toxin: the role of promoter cis-elements in its expression. Thromb Haemost. 2009;102:469-78 pubmed publisher
    ..Trocarin D is hypothesised to have evolved from its factor X counterpart (TrFX) through gene duplication and recruitment...
  5. Suntravat M, Nuchprayoon I, Perez J. Comparative study of anticoagulant and procoagulant properties of 28 snake venoms from families Elapidae, Viperidae, and purified Russell's viper venom-factor X activator (RVV-X). Toxicon. 2010;56:544-53 pubmed
    ..b>Factor X activator activity was also measured in 28 venoms, and D. r. siamensis venom was 5-6 times higher than those of B...
  6. Herrmann F, Navarette M, Salazar Sanchez L, Carillo J, Auerswald G, Wulff K. Homozygous Factor X gene mutations Gly380Arg and Tyr163delAT are associated with perinatal intracranial hemorrhage. J Pediatr. 2005;146:128-30 pubmed
    Intracranial hemorrhage (ICH) is a severe complication of Factor X (FX) deficiency. We report 6 homozygous patients with central nervous system (ICH) bleeds...
  7. Zaiss A, Lawrence R, Elashoff D, Esko J, Herschman H. Differential effects of murine and human factor X on adenovirus transduction via cell-surface heparan sulfate. J Biol Chem. 2011;286:24535-43 pubmed publisher
    Serum coagulation factor X (FX) is proposed to play a major role in adenovirus tropism, promoting transduction by bridging the virus to cell-surface heparan sulfate proteoglycans (HSPGs)...
  8. Craft J, Epps K, Brancato S, Serfis A. Incorporation of blood clotting factor X into phospholipid model membranes: fluorescence microscopy imaging and subphase effects surrounding the lipid phase transition region. J Colloid Interface Sci. 2003;268:181-7 pubmed
    b>Factor X is a blood clotting protein that associates at membrane surfaces to become activated during the coagulation cascade...
  9. Ahmad S, London F, Walsh P. The assembly of the factor X-activating complex on activated human platelets. J Thromb Haemost. 2003;1:48-59 pubmed
    Platelet membranes provide procoagulant surfaces for the assembly and expression of the factor X-activating complex and promote the proteolytic activation and assembly of the prothrombinase complex resulting in normal hemostasis...

More Information

Publications62

  1. Rudolph A, Mullane M, Porche Sorbet R, Daust H, Miletich J. The role of the factor X activation peptide: a deletion mutagenesis approach. Thromb Haemost. 2002;88:756-62 pubmed
    To understand the role of the factor X (fX) activation peptide (AP), a deletion mutagenesis approach was employed...
  2. Breems D, Sonneveld P, de Man R, Leebeek F. Successful treatment of systemic amyloidosis with hepatic involvement and factor X deficiency by high dose melphalan chemotherapy and autologous stem cell reinfusion. Eur J Haematol. 2004;72:181-5 pubmed
    ..We present two patients with a severe factor X deficiency and hepatomegaly as the presenting abnormalities of systemic amyloidosis...
  3. Tai S, Herzog R, Margaritis P, Arruda V, Chu K, Golden J, et al. A viable mouse model of factor X deficiency provides evidence for maternal transfer of factor X. J Thromb Haemost. 2008;6:339-45 pubmed
    Activated factor X (FXa) is a vitamin K-dependent serine protease that plays a pivotal role in blood coagulation by converting prothrombin to thrombin...
  4. Parker A, Waddington S, Buckley S, Custers J, Havenga M, Van Rooijen N, et al. Effect of neutralizing sera on factor x-mediated adenovirus serotype 5 gene transfer. J Virol. 2009;83:479-83 pubmed publisher
    ..When such vectors are delivered intravenously, hepatocyte transduction is mediated by the hexon-coagulation factor X (FX) interaction...
  5. Alba R, Bradshaw A, Parker A, Bhella D, Waddington S, Nicklin S, et al. Identification of coagulation factor (F)X binding sites on the adenovirus serotype 5 hexon: effect of mutagenesis on FX interactions and gene transfer. Blood. 2009;114:965-71 pubmed publisher
    Recent studies have demonstrated the importance of coagulation factor X (FX) in adenovirus (Ad) serotype 5-mediated liver transduction in vivo. FX binds to the adenovirus hexon hypervariable regions (HVRs)...
  6. Greig J, Buckley S, Waddington S, Parker A, Bhella D, Pink R, et al. Influence of coagulation factor x on in vitro and in vivo gene delivery by adenovirus (Ad) 5, Ad35, and chimeric Ad5/Ad35 vectors. Mol Ther. 2009;17:1683-91 pubmed publisher
    The binding of coagulation factor X (FX) to the hexon of adenovirus (Ad) 5 is pivotal for hepatocyte transduction...
  7. Brecher A, Hommema E. The influence of acetaldehyde and glycosaminoglycans upon factor Xa- and factor X-deficient plasma. Can J Physiol Pharmacol. 2002;80:879-86 pubmed
    ..effects of glycosaminoglycans and acetaldehyde (AcH)--glycosaminoglycan (GAG) mixtures upon Factor Xa- (FXa) and Factor X-deficient plasma (FXDP) have been studied by activated partial thromboplastin time (APTT) studies. Heparin at 0...
  8. Short J, Rivera A, Wu H, Walter M, Yamamoto M, Mathis J, et al. Substitution of adenovirus serotype 3 hexon onto a serotype 5 oncolytic adenovirus reduces factor X binding, decreases liver tropism, and improves antitumor efficacy. Mol Cancer Ther. 2010;9:2536-44 pubmed publisher
    ..In this regard, it has recently been shown that the Ad5 capsid binds to the blood coagulation factor X (FX) via the Ad5 hexon protein. This interaction mediates the majority of Ad5 liver transduction...
  9. Johansson L, Karpf D, Hansen L, Pelzer H, Persson E. Activation peptides prolong the murine plasma half-life of human factor VII. Blood. 2011;117:3445-52 pubmed publisher
    ..Our data support that activation peptides function as plasma retention signals and constitute a new manner to extend the half-life of FVII(a). ..
  10. Nogami K, Freas J, Manithody C, Wakabayashi H, Rezaie A, Fay P. Mechanisms of interactions of factor X and factor Xa with the acidic region in the factor VIII A1 domain. J Biol Chem. 2004;279:33104-13 pubmed
    The 337-372 sequence of the factor VIIIa A1 subunit contains interactive sites for both zymogen factor X and the active enzyme, factor Xa...
  11. Chen C, May S, Barry M. Targeting adenoviruses with factor x-single-chain antibody fusion proteins. Hum Gene Ther. 2010;21:739-49 pubmed publisher
    Abstract It has been shown that blood clotting factors, including factor X (FX), bind to the adenovirus serotype 5 (Ad5) hexon protein and target the virus to liver hepatocytes after intravenous injection...
  12. Louvain Quintard V, Bianchini E, Calmel Tareau C, Tagzirt M, Le Bonniec B. Thrombin-activable factor X re-establishes an intrinsic amplification in tenase-deficient plasmas. J Biol Chem. 2005;280:41352-9 pubmed
    Classical hemophilia results from a defect of the intrinsic tenase complex, the main factor X (FX) activator. Binding of factor VIIa to tissue factor triggers coagulation, but little amplification of thrombin production occurs...
  13. Duffy M, Bradshaw A, Parker A, McVey J, Baker A. A cluster of basic amino acids in the factor X serine protease mediates surface attachment of adenovirus/FX complexes. J Virol. 2011;85:10914-9 pubmed publisher
    ..following intravenous administration of adenovirus 5 (Ad5) is mediated by interaction between coagulation factor X (FX) and the hexon...
  14. Menegatti M, Peyvandi F. Factor X deficiency. Semin Thromb Hemost. 2009;35:407-15 pubmed publisher
    b>Factor X (FX) deficiency is a rare, recessively inherited bleeding disorder representing 10% of all rare bleeding diseases and affecting 1 in every 1,000,000 people...
  15. Sierko E, Wojtukiewicz M, Zimnoch L, Tokajuk P, Ostrowska Cichocka K, Kisiel W. Co-localization of Protein Z, Protein Z-Dependent protease inhibitor and coagulation factor X in human colon cancer tissue: implications for coagulation regulation on tumor cells. Thromb Res. 2012;129:e112-8 pubmed publisher
    Several hemostatic system components, including factor X (FX), contribute to cancer progression. The Protein Z (PZ)/protein Z-dependent protease inhibitor (ZPI) complex directly inhibits factor Xa proteolytic activity...
  16. Di Paolo N, Van Rooijen N, Shayakhmetov D. Redundant and synergistic mechanisms control the sequestration of blood-born adenovirus in the liver. Mol Ther. 2009;17:675-84 pubmed publisher
    ..Therefore, our study is the first demonstration of the principal possibility of ablating the sequestration of blood-born Ad in the liver via specific inactivation of a defined set of mechanisms that control this process. ..
  17. Fribourg C, Meijer A, Mertens K. The interface between the EGF2 domain and the protease domain in blood coagulation factor IX contributes to factor VIII binding and factor X activation. Biochemistry. 2006;45:10777-85 pubmed
    ..All FIXa mutants, however, exhibited a reduced level of factor X (FX) activation...
  18. Alba R, Bradshaw A, Mestre Frances N, Verdier J, Henaff D, Baker A. Coagulation factor X mediates adenovirus type 5 liver gene transfer in non-human primates (Microcebus murinus). Gene Ther. 2012;19:109-13 pubmed publisher
    Coagulation factor X (FX)-binding ablated adenovirus type 5 (Ad5) vectors have been genetically engineered to ablate the interaction with FX, resulting in substantially reduced hepatocyte transduction following intravenous administration ..
  19. Waddington S, McVey J, Bhella D, Parker A, Barker K, Atoda H, et al. Adenovirus serotype 5 hexon mediates liver gene transfer. Cell. 2008;132:397-409 pubmed publisher
    ..Liver infection by the FX-Ad5 complex is mediated through a heparin-binding exosite in the FX serine protease domain. This study reveals an unanticipated function for hexon in mediating liver gene transfer in vivo...
  20. Pabinger I, Brenner B, Kalina U, Knaub S, Nagy A, Ostermann H. Prothrombin complex concentrate (Beriplex P/N) for emergency anticoagulation reversal: a prospective multinational clinical trial. J Thromb Haemost. 2008;6:622-31 pubmed publisher
    ..PCC treatment serves as an effective rapid hemorrhage control resource in the emergency anticoagulant reversal setting. More widespread availability of PCC is warranted to ensure its benefits in appropriate patients. ..
  21. Bradshaw A, Parker A, Duffy M, Coughlan L, Van Rooijen N, Kahari V, et al. Requirements for receptor engagement during infection by adenovirus complexed with blood coagulation factor X. PLoS Pathog. 2010;6:e1001142 pubmed publisher
    Human adenoviruses from multiple species bind to coagulation factor X (FX), yet the importance of this interaction in adenovirus dissemination is unknown...
  22. Uprichard J, Perry D. Factor X deficiency. Blood Rev. 2002;16:97-110 pubmed
    b>Factor X is one of the vitamin K-dependent serine proteases. It plays a crucial role in the coagulation cascade, as the first enzyme in the common pathway of thrombus formation...
  23. Chen H, Chen J, Lin C, Khoo K, Tsai I. New insights into the functions and N-glycan structures of factor X activator from Russell's viper venom. FEBS J. 2008;275:3944-58 pubmed publisher
    The coagulation factor X activator from Russell's viper venom (RVV-X) is a heterotrimeric glycoprotein. In this study, its three subunits were cloned and sequenced from the venom gland cDNAs of Daboia siamensis...
  24. Siigur E, Aaspõllu A, Trummal K, Tõnismägi K, Tammiste I, Kalkkinen N, et al. Factor X activator from Vipera lebetina venom is synthesized from different genes. Biochim Biophys Acta. 2004;1702:41-51 pubmed
    Vipera lebetina venom contains specific coagulant Factor X activator (VLFXA) that cleaves the Arg52-Ile53 bond in the heavy chain of human factor X...
  25. Reza A, Swarup S, Manjunatha Kini R. Two parallel prothrombin activator systems in Australian rough-scaled snake, Tropidechis carinatus. Structural comparison of venom prothrombin activator with blood coagulation factor X. Thromb Haemost. 2005;93:40-7 pubmed
    ..Here, we report the complete cDNA sequence encoding the blood coagulation factor X (FX) from the liver of T. carinatus. Deduced T...
  26. Jayandharan G, Viswabandya A, Baidya S, Nair S, Shaji R, George B, et al. Six novel mutations including triple heterozygosity for Phe31Ser, 514delT and 516T-->G factor X gene mutations are responsible for congenital factor X deficiency in patients of Nepali and Indian origin. J Thromb Haemost. 2005;3:1482-7 pubmed
    b>Factor X (FX) deficiency is a rare (1 : 100000) autosomal recessive disorder caused by heterogeneous mutations in FX gene. We have studied the molecular basis this disease in six Indian and one Nepali patients...
  27. Hathcock J, Rusinova E, Gentry R, Andree H, Nemerson Y. Phospholipid regulates the activation of factor X by tissue factor/factor VIIa (TF/VIIa) via substrate and product interactions. Biochemistry. 2005;44:8187-97 pubmed
    ..to already relipidated TF (30/70 PS/PC) and found that added lipid can both enhance and inhibit the rate of factor X (F.X) activation. Using active-site-inhibited F.Xa we demonstrate that F...
  28. Monteiro R, Rezaie A, Bae J, Calvo E, Andersen J, Francischetti I. Ixolaris binding to factor X reveals a precursor state of factor Xa heparin-binding exosite. Protein Sci. 2008;17:146-53 pubmed
    ..Ixolaris may be a useful tool to study the physiological role of the FX HBPE and to evaluate this domain as a target for anticoagulant drugs. ..
  29. Herrmann F, Auerswald G, Ruiz Saez A, Navarrete M, Pollmann H, Lopaciuk S, et al. Factor X deficiency: clinical manifestation of 102 subjects from Europe and Latin America with mutations in the factor 10 gene. Haemophilia. 2006;12:479-89 pubmed
    Inherited factor X deficiency (FXD) is a rare (1:1,000,000) recessive bleeding disorder...
  30. Livingston J, Sutherland M, Friedman H, Pryzdial E. Herpes simplex virus type 1-encoded glycoprotein C contributes to direct coagulation factor X-virus binding. Biochem J. 2006;393:529-35 pubmed publisher
    ..recently to initiate blood coagulation by FVIIa (activated Factor VII)-dependent proteolytic activation of FX (Factor X)...
  31. Disse J, Petersen H, Larsen K, Persson E, ESMON N, Esmon C, et al. The endothelial protein C receptor supports tissue factor ternary coagulation initiation complex signaling through protease-activated receptors. J Biol Chem. 2011;286:5756-67 pubmed publisher
  32. Sun Y, Jin D, Camire R, Stafford D. Vitamin K epoxide reductase significantly improves carboxylation in a cell line overexpressing factor X. Blood. 2005;106:3811-5 pubmed
    Previously we reported that we could increase the fraction of carboxylated factor X by reducing the affinity of the propeptide for its binding site on human gamma glutamyl carboxylase. We attributed this to an increased turnover rate...
  33. Rosen E, Cornelissen I, Liang Z, Zollman A, Casad M, Roahrig J, et al. In utero transplantation of wild-type fetal liver cells rescues factor X-deficient mice from fatal neonatal bleeding diatheses. J Thromb Haemost. 2003;1:19-27 pubmed
    b>Factor X (FX)-deficient embryos suffer partial embryonic lethality with approximately 30% of the embryos arresting at midgestation. The remaining animals survive to term but die perinatally mainly from abdominal or intracranial hemorrhage...
  34. Richter G, Schwarz H, Dorner F, Turecek P. Activation and inactivation of human factor X by proteases derived from Ficus carica. Br J Haematol. 2002;119:1042-51 pubmed
    ..the prothrombin time of normal plasmas and plasmas deficient in coagulation factors, except plasma deficient in factor X (FX) and generated activated FX (FXa) in defibrinated plasma...
  35. Yang Y, Hwang K, FitzGerald J, Grossman J, Taylor M, Hahn B, et al. Antibodies against the activated coagulation factor X (FXa) in the antiphospholipid syndrome that interfere with the FXa inactivation by antithrombin. J Immunol. 2006;177:8219-25 pubmed
    ..Considering that activated coagulation factor X (FXa) is homologous to thrombin in the catalytic domains and is also regulated primarily by AT, we hypothesized ..
  36. Hollenstein U, Pernerstorfer T, Homoncik M, Hansen J, Finzen H, Handler S, et al. Effect of factor X inhibition on coagulation activation and cytokine induction in human systemic inflammation. J Infect Dis. 2002;186:1270-6 pubmed
    ..Danaparoid therefore selectively attenuates endotoxin-induced coagulopathy, even with delayed administration when coagulation activation is well under way. ..
  37. Kalyuzhniy O, Di Paolo N, Silvestry M, Hofherr S, Barry M, Stewart P, et al. Adenovirus serotype 5 hexon is critical for virus infection of hepatocytes in vivo. Proc Natl Acad Sci U S A. 2008;105:5483-8 pubmed publisher
    ..Here, we report that the major Ad5 capsid protein, hexon, binds human coagulation factor X (FX) with an affinity of 229 pM...
  38. Wei Z, Yan Y, Carrell R, Zhou A. Crystal structure of protein Z-dependent inhibitor complex shows how protein Z functions as a cofactor in the membrane inhibition of factor X. Blood. 2009;114:3662-7 pubmed publisher
    ..PZ) binds to PZ-dependent inhibitor (ZPI) and accelerates the inhibition of the coagulation protease, activated factor X (FXa), in the presence of phospholipids and Ca2+. A 2...
  39. Parker A, Waddington S, Nicol C, Shayakhmetov D, Buckley S, Denby L, et al. Multiple vitamin K-dependent coagulation zymogens promote adenovirus-mediated gene delivery to hepatocytes. Blood. 2006;108:2554-61 pubmed
    ..Our results indicate a common and pivotal role for distinct vitamin K-dependent coagulation factors in mediating hepatocyte transduction by adenoviruses in vitro and in vivo...
  40. Jiao J, Kelly A, Marzec U, Nieves E, Acevedo J, Burkhardt M, et al. Inhibition of acute vascular thrombosis in chimpanzees by an anti-human tissue factor antibody targeting the factor X binding site. Thromb Haemost. 2010;103:224-33 pubmed publisher
    ..evaluate whether a human/mouse chimeric monoclonal antibody (ALT-836, formerly known as Sunol-cH36) blocking the factor X/factor IX (FX/FIX) binding site of tissue factor could achieve similar clinical benefits in an arterial ..
  41. Corjon S, Gonzalez G, Henning P, Grichine A, Lindholm L, Boulanger P, et al. Cell entry and trafficking of human adenovirus bound to blood factor X is determined by the fiber serotype and not hexon:heparan sulfate interaction. PLoS ONE. 2011;6:e18205 pubmed publisher
    ..administered intravenously accumulate in the liver as the result of their direct binding to blood coagulation factor X (FX) and subsequent interaction of the FX-HAdV5 complex with heparan sulfate proteoglycan (HSPG) at the surface ..
  42. McGlasson D, Kaczor D, Krasuski R, Campbell C, Kostur M, Adinaro J. Effects of pre-analytical variables on the anti-activated factor X chromogenic assay when monitoring unfractionated heparin and low molecular weight heparin anticoagulation. Blood Coagul Fibrinolysis. 2005;16:173-6 pubmed
    The purpose of this study was to determine whether the anti-activated factor X (anti-FXa) assay is less affected by pre-analytical variables in monitoring patients on unfractionated heparin (UFH) and low molecular weight heparin (LMWH) ..
  43. Erb E, Stenflo J, Drakenberg T. Interaction of bovine coagulation factor X and its glutamic-acid-containing fragments with phospholipid membranes. A surface plasmon resonance study. Eur J Biochem. 2002;269:3041-6 pubmed
    The interaction of blood coagulation factor X and its Gla-containing fragments with negatively charged phospholipid membranes composed of 25 mol% phosphatidylserine (PtdSer) and 75 mol% phosphatidylcholine (PtdCho) was studied by surface ..
  44. Fromovich Amit Y, Zivelin A, Rosenberg N, Landau M, Rosa J, Seligsohn U. Of four mutations in the factor VII gene in Tunisian patients, one novel mutation (Ser339Phe) in three unrelated families abrogates factor X activation. Blood Coagul Fibrinolysis. 2005;16:369-74 pubmed
    ..of commercial recombinant activated FVII or recombinant wild-type FVII and was normally activated by activated factor X. The major defect of FVII Ser339Phe was its inability to activate factor X in the presence of tissue factor...
  45. Matsui H, Sakurai F, Katayama K, Yamaguchi T, Okamoto S, Takahira K, et al. A hexon-specific PEGylated adenovirus vector utilizing blood coagulation factor X. Biomaterials. 2012;33:3743-55 pubmed publisher
    ..we developed a new method for hexon-specific PEGylation by mixing Ad vectors with PEGylated blood coagulation factor X (FX) (PEG-FX)...
  46. Xu Z, Qiu Q, Tian J, Smith J, Conenello G, Morita T, et al. Coagulation factor X shields adenovirus type 5 from attack by natural antibodies and complement. Nat Med. 2013;19:452-7 pubmed publisher
    Adenovirus type 5 (Ad5) specifically binds coagulation factor X (FX), and FX is normally essential for intravenously injected Ad5 vectors to transduce the liver...
  47. Alba R, Bradshaw A, Coughlan L, Denby L, McDonald R, Waddington S, et al. Biodistribution and retargeting of FX-binding ablated adenovirus serotype 5 vectors. Blood. 2010;116:2656-64 pubmed publisher
    ..Recently, we demonstrated that coagulation factor X (FX) binds to Ad5-hexon protein at high affinity to mediate hepatocyte transduction after intravascular delivery...
  48. Yang L, Manithody C, Rezaie A. Functional role of O-linked and N-linked glycosylation sites present on the activation peptide of factor X. J Thromb Haemost. 2009;7:1696-702 pubmed publisher
    There are two O-linked and two N-linked glycosylation sites on the activation peptide of factor X (FX) involving residues Thr-17, Thr-29, Asn-39 and Asn-49...
  49. Jonsson M, Lenman A, Frängsmyr L, Nyberg C, Abdullahi M, Arnberg N. Coagulation factors IX and X enhance binding and infection of adenovirus types 5 and 31 in human epithelial cells. J Virol. 2009;83:3816-25 pubmed publisher
  50. Reza M, Swarup S, Kini R. Structure of two genes encoding parallel prothrombin activators in Tropidechis carinatus snake: gene duplication and recruitment of factor X gene to the venom gland. J Thromb Haemost. 2007;5:117-26 pubmed
    ..Thus, we named this segment as VERSE (Venom Recruitment/Switch Element). To our knowledge, this is the first molecular evidence for the recruitment of a duplicated gene for expression in venom glands by a simple insertion. ..
  51. Kritz A, Nicol C, Dishart K, Nelson R, Holbeck S, Von Seggern D, et al. Adenovirus 5 fibers mutated at the putative HSPG-binding site show restricted retargeting with targeting peptides in the HI loop. Mol Ther. 2007;15:741-9 pubmed
    ..Cy3 labeling studies showed retarded trafficking of S*-containing fibers. Taken together, our data demonstrates that KO1S* mutant fibers are ineffective for cell retargeting strategies. ..
  52. Panteleev M, Ananyeva N, Greco N, Ataullakhanov F, Saenko E. Two subpopulations of thrombin-activated platelets differ in their binding of the components of the intrinsic factor X-activating complex. J Thromb Haemost. 2005;3:2545-53 pubmed
  53. Girard T. A factor X-TFPI hybrid protein inhibits B16 melanoma metastatic growth in mice. Thromb Res. 2007;121:427-8 pubmed