nephroblastoma overexpressed protein


Summary: A CCN protein family member found at high levels in NEPHROBLASTOMA cells. It is found both intracellularly and in the EXTRACELLULAR MATRIX and may play a role in the regulation of CELL PROLIFERATION and EXTRACELLULAR MATRIX synthesis.

Top Publications

  1. Zhang C, van der Voort D, Shi H, Zhang R, Qing Y, Hiraoka S, et al. Matricellular protein CCN3 mitigates abdominal aortic aneurysm. J Clin Invest. 2016;126:1282-99 pubmed publisher
    ..Together, these results demonstrate that CCN3 is a nodal regulator in AAA biology and identify CCN3 as a potential therapeutic target for vascular disease. ..
  2. Xu E, Blythe E, Fischer G, Hyvonen M. Structural analyses of von Willebrand factor C domains of collagen 2A and CCN3 reveal an alternative mode of binding to bone morphogenetic protein-2. J Biol Chem. 2017;292:12516-12527 pubmed publisher
    ..This binding site is different from that previously observed in the complex between CV-2 vWC and BMP-2, revealing an alternative mode of interaction between vWC domains and BMPs. ..
  3. Shi H, Zhang C, Pasupuleti V, Hu X, Prosdocimo D, Wu W, et al. CCN3 Regulates Macrophage Foam Cell Formation and Atherosclerosis. Am J Pathol. 2017;187:1230-1237 pubmed publisher
    ..These results suggest that bone marrow-derived CCN3 is an essential regulator of atherosclerosis and point to a novel role of CCN3 in modulating lipid accumulation within macrophages. ..
  4. Cao J, Singh S, McClung J, Joseph G, Vanella L, Barbagallo I, et al. EET intervention on Wnt1, NOV, and HO-1 signaling prevents obesity-induced cardiomyopathy in obese mice. Am J Physiol Heart Circ Physiol. 2017;313:H368-H380 pubmed publisher
    ..Listen to this article's corresponding podcast at ..
  5. Kii I, Ito H. Periostin and its interacting proteins in the construction of extracellular architectures. Cell Mol Life Sci. 2017;74:4269-4277 pubmed publisher