rod opsins


Summary: Photosensitive proteins expressed in the ROD PHOTORECEPTOR CELLS. They are the protein components of rod photoreceptor pigments such as RHODOPSIN.

Top Publications

  1. Kawasaki A, Herbst K, Sander B, Milea D. Selective wavelength pupillometry in Leber hereditary optic neuropathy. Clin Exp Ophthalmol. 2010;38:322-4 pubmed publisher
  2. Monteggia L, Kavalali E. Circadian rhythms: Depression brought to light. Nature. 2012;491:537-8 pubmed publisher
  3. Corson D, Kefalov V, Cornwall M, Crouch R. Effect of 11-cis 13-demethylretinal on phototransduction in bleach-adapted rod and cone photoreceptors. J Gen Physiol. 2000;116:283-97 pubmed
  4. Zhao X, Reifler A, Schroeder M, Jaeckel E, Chervenak A, Wong K. Mechanisms creating transient and sustained photoresponses in mammalian retinal ganglion cells. J Gen Physiol. 2017;149:335-353 pubmed publisher
    ..Parenthetically, we find evidence in both mice and rats that the kinetics of light-induced mGluR6 deactivation determines whether an ON bipolar cell responds tonically or transiently to light. ..
  5. Qiao S, Zhou W, Liu L, Zhang D, Zhong Y. Orexin-A Suppresses Signal Transmission to Dopaminergic Amacrine Cells From Outer and Inner Retinal Photoreceptors. Invest Ophthalmol Vis Sci. 2017;58:4712-4721 pubmed publisher
    ..Our results suggest that orexins could influence visual function via the dopaminergic system in the mammalian retina. ..
  6. Giraldo Calderón G, Zanis M, Hill C. Retention of duplicated long-wavelength opsins in mosquito lineages by positive selection and differential expression. BMC Evol Biol. 2017;17:84 pubmed publisher
  7. Musser J, Arendt D. Loss and gain of cone types in vertebrate ciliary photoreceptor evolution. Dev Biol. 2017;431:26-35 pubmed publisher
    ..These findings underscore the importance of specifying transcription factors in tracking cell type evolution, and shed new light on the mechanisms of cell type loss and gain in retina evolution. ..
  8. Maynard M, Zele A, Kwan A, Feigl B. Intrinsically Photosensitive Retinal Ganglion Cell Function, Sleep Efficiency and Depression in Advanced Age-Related Macular Degeneration. Invest Ophthalmol Vis Sci. 2017;58:990-996 pubmed publisher
    ..The correlation between the melanopsin-mediated PIPR and sleep may indicate reduced photic input to the suprachiasmatic nucleus and ventrolateral preoptic area due to ipRGC dysfunction in AMD. ..
  9. García Ayuso D, Galindo Romero C, Di Pierdomenico J, Vidal Sanz M, Agudo Barriuso M, Villegas Pérez M. Light-induced retinal degeneration causes a transient downregulation of melanopsin in the rat retina. Exp Eye Res. 2017;161:10-16 pubmed publisher
    ..Further studies would be needed to clarify the long-term effect of light exposure on the m+RGC population. ..

More Information


  1. Tsuchiya S, Buhr E, Higashide T, Sugiyama K, Van Gelder R. Light entrainment of the murine intraocular pressure circadian rhythm utilizes non-local mechanisms. PLoS ONE. 2017;12:e0184790 pubmed publisher
    ..These results suggest that IOP rhythm entrainment is mediated by a systemic rather than local signal in mice. ..
  2. Liu M, Farkas M, Spinnhirny P, Pevet P, PIERCE E, Hicks D, et al. De novo assembly and annotation of the retinal transcriptome for the Nile grass rat (Arvicanthis ansorgei). PLoS ONE. 2017;12:e0179061 pubmed publisher
    ..Our high quality annotated transcriptome is publicly available, and we hope it will facilitate wider usage of A. ansorgei as a model organism for molecular studies of cone biology and retinal degeneration. ..
  3. Kelbsch C, Maeda F, Strasser T, Peters T, Wilhelm B, Wilhelm H. Color Pupillography in Dorsal Midbrain Syndrome. J Neuroophthalmol. 2017;37:247-252 pubmed publisher
    ..Moreover, there was a preserved postillumination pupil response to blue stimulation in DMS patients. In DMS, the melanopsin-mediated ipRGC pathway appeared relatively preserved. ..
  4. Charng J, Jacobson S, Heon E, Roman A, McGuigan D, Sheplock R, et al. Pupillary Light Reflexes in Severe Photoreceptor Blindness Isolate the Melanopic Component of Intrinsically Photosensitive Retinal Ganglion Cells. Invest Ophthalmol Vis Sci. 2017;58:3215-3224 pubmed publisher
  5. Nandamuri S, Dalton B, Carleton K. Determination of the Genetic Architecture Underlying Short Wavelength Sensitivity in Lake Malawi Cichlids. J Hered. 2017;108:379-390 pubmed publisher
    ..This knowledge will help answer long-standing questions about the evolutionary processes fundamental to opsin expression variation and how this contributes to adaptive cichlid divergence. ..
  6. Orosz O, Rajta I, Vajas A, Takacs L, Csutak A, Fodor M, et al. Myopia and Late-Onset Progressive Cone Dystrophy Associate to LVAVA/MVAVA Exon 3 Interchange Haplotypes of Opsin Genes on Chromosome X. Invest Ophthalmol Vis Sci. 2017;58:1834-1842 pubmed publisher
    ..To the best of our knowledge, this is the first report on the joint effect of these toxic haplotypes in the two opsin genes on chromosome X. ..
  7. Hannibal J, Christiansen A, Heegaard S, Fahrenkrug J, Kiilgaard J. Melanopsin expressing human retinal ganglion cells: Subtypes, distribution, and intraretinal connectivity. J Comp Neurol. 2017;525:1934-1961 pubmed publisher
    ..The study characterizes a heterogenic population of human melanopsin-ir RGCs, which most likely are involved in different functions. ..
  8. Park J, McAnany J. Effect of stimulus size and luminance on the rod-, cone-, and melanopsin-mediated pupillary light reflex. J Vis. 2015;15: pubmed publisher
    ..These findings highlight important differences in how stimulus luminance and size combine to govern the PLR elicited by brief flashes under rod-, cone-, and melanopsin-mediated conditions. ..