Summary: Chloro(7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N(21),N(22),N(23),N(24)) ferrate(2-) dihydrogen.

Top Publications

  1. Cao Z, Geng B, Xu S, Xuan W, Nie L, Shen W, et al. BnHO1, a haem oxygenase-1 gene from Brassica napus, is required for salinity and osmotic stress-induced lateral root formation. J Exp Bot. 2011;62:4675-89 pubmed publisher
    ..Taken together, these results suggested a novel role of the rapeseed HO-1 gene in salinity and osmotic stress-induced LR formation, with a possible interaction with auxin signalling...
  2. Wang R, Nan Y, Wu W, Kong L, Han F, Zhao S, et al. Induction of heme oxygenase-1 protects against nutritional fibrosing steatohepatitis in mice. Lipids Health Dis. 2011;10:31 pubmed publisher
    ..HO-1 chemical inducer (hemin), HO-1 chemical inhibitor zinc protoporphyrin IX (ZnPP-IX) and/or adenovirus carrying HO-1 gene (Ad-HO-1) were ..
  3. Cambos M, Scorza T. Robust erythrophagocytosis leads to macrophage apoptosis via a hemin-mediated redox imbalance: role in hemolytic disorders. J Leukoc Biol. 2011;89:159-71 pubmed publisher
  4. Jepkorir G, Rodriguez J, Rui H, Im W, Lovell S, Battaile K, et al. Structural, NMR spectroscopic, and computational investigation of hemin loading in the hemophore HasAp from Pseudomonas aeruginosa. J Am Chem Soc. 2010;132:9857-72 pubmed publisher
    When challenged by low-iron conditions several Gram-negative pathogens secrete a hemophore (HasA) to scavenge hemin from its host and deliver it to a receptor (HasR) on their outer membrane for internalization...
  5. Cambos M, Bazinet S, Abed E, Sanchez Dardon J, Bernard C, Moreau R, et al. The IL-12p70/IL-10 interplay is differentially regulated by free heme and hemozoin in murine bone-marrow-derived macrophages. Int J Parasitol. 2010;40:1003-12 pubmed publisher
    ..Herein, the effect of hemin (HE) on IL-12 and IL-10 responses was studied in murine bone marrow-derived macrophages (BMDM) and compared with ..
  6. Awede B, Lemaire M, Hyvelin J, Halimi J, Bonnet P, Eder V. Hemin, a carbon monoxide donor, improves systemic vascular compliance by inhibiting the RhoA-Rhokinase pathway in spontaneous hypertensive rats. Eur J Pharmacol. 2010;626:256-61 pubmed publisher
    ..We performed this study in order to determine the impact of Hemin on smooth muscle layer vasoreactivity in spontaneous hypertensive rats as compared to control Wistar rats...
  7. Gueron G, De Siervi A, Ferrando M, Salierno M, De Luca P, Elguero B, et al. Critical role of endogenous heme oxygenase 1 as a tuner of the invasive potential of prostate cancer cells. Mol Cancer Res. 2009;7:1745-55 pubmed publisher
    ..Our results show that HO-1 levels are markedly decreased in PC3 compared with MDA PCa2b and LNCaP. Hemin treatment increased HO-1 at both protein and mRNA levels in all cell lines and decreased cell proliferation and ..
  8. Han J, Zhou Z, Bu X, Zhu S, Zhang H, Sun H, et al. Employing aqueous CdTe quantum dots with diversified surface functionalities to discriminate between heme (Fe(II)) and hemin (Fe(III)). Analyst. 2013;138:3402-8 pubmed publisher
    ..quantum dots (QDs) with diversified surface functionalities are applied to discriminate between heme (Fe(II)) and hemin (Fe(III)) by virtue of their difference in quenching QD fluorescence...
  9. Kumar R, Lovell S, Matsumura H, Battaile K, Moenne Loccoz P, Rivera M. The hemophore HasA from Yersinia pestis (HasAyp) coordinates hemin with a single residue, Tyr75, and with minimal conformational change. Biochemistry. 2013;52:2705-7 pubmed publisher
    Hemophores from Serratia marcescens (HasA(sm)) and Pseudomonas aeruginosa (HasA(p)) bind hemin between two loops, which harbor the axial ligands H32 and Y75...

Scientific Experts

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  1. Mullié C, Jonet A, Desgrouas C, Taudon N, Sonnet P. Differences in anti-malarial activity of 4-aminoalcohol quinoline enantiomers and investigation of the presumed underlying mechanism of action. Malar J. 2012;11:65 pubmed publisher
    ..The inhibition of ?-haematin formation and haemin peroxidation can be put forward as presumed mechanisms of action but do not account for the stereoselectivity of action witnessed in vitro. ..
  2. Stefan L, Denat F, Monchaud D. Deciphering the DNAzyme activity of multimeric quadruplexes: insights into their actual role in the telomerase activity evaluation assay. J Am Chem Soc. 2011;133:20405-15 pubmed publisher
    ..It has been widely demonstrated that, upon interaction with hemin, discrete quadruplexes acquire peroxidase-mimicking properties, oxidizing several organic probes in H(2)O(2)-rich ..
  3. Jones C, Niederweis M. Mycobacterium tuberculosis can utilize heme as an iron source. J Bacteriol. 2011;193:1767-70 pubmed publisher
    ..Here, we demonstrate that Mycobacterium tuberculosis can utilize heme as an iron source, suggesting that M. tuberculosis possesses a yet-unknown heme acquisition system. ..
  4. Sonnet P, Mullie C. In vitro antimalarial activity of ICL670: a further proof of the correlation between inhibition of ?-hematin formation and of peroxidative degradation of hemin. Exp Parasitol. 2011;128:26-31 pubmed publisher
    ..on inhibition of ?-hematin formation and on both peroxidative and glutathione (GSH)-mediated degradation of hemin were investigated...
  5. Kong D, Xu J, Shen H. Positive effects of ATP on G-quadruplex-hemin DNAzyme-mediated reactions. Anal Chem. 2010;82:6148-53 pubmed publisher
    Some G-quadruplex-hemin complexes can be used as peroxidase-mimicking DNAzymes, catalyzing H(2)O(2)-mediated reactions such as the oxidation of 2,2'-azinobis (3-ethylbenzothiozoline)-6-sulfonic acid (ABTS) by H(2)O(2)...
  6. Mullié C, Jonet A, Dassonville Klimpt A, Gosmann G, Sonnet P. Inhibitory effect of ursolic acid derivatives on hydrogen peroxide- and glutathione-mediated degradation of hemin: a possible additional mechanism of action for antimalarial activity. Exp Parasitol. 2010;125:202-7 pubmed publisher
    ..here the results of additional pathways that may explain their in vitro cytocidal activity such as inhibition of hemin degradation by H(2)O(2) or glutathione (GSH)...
  7. Bharucha A, Kulkarni A, Choi K, Camilleri M, Lempke M, Brunn G, et al. First-in-human study demonstrating pharmacological activation of heme oxygenase-1 in humans. Clin Pharmacol Ther. 2010;87:187-90 pubmed publisher
    ..In this randomized study of 10 healthy volunteers, hemin (3 mg/kg intravenously in 25% albumin) was shown to increase plasma HO-1 protein concentration four- to fivefold ..
  8. Worou M, Belmokhtar K, Bonnet P, Vourc H P, Machet M, Khamis G, et al. Hemin decreases cardiac oxidative stress and fibrosis in a rat model of systemic hypertension via PI3K/Akt signalling. Cardiovasc Res. 2011;91:320-9 pubmed publisher
    ..The aim of this work was to assess the impact of hemin (heme oxygenase-1 inducer) on NADPH oxidase activation, cardiac oxidative stress, and development of fibrosis in a ..
  9. Yukl E, Jepkorir G, Alontaga A, Pautsch L, Rodriguez J, Rivera M, et al. Kinetic and spectroscopic studies of hemin acquisition in the hemophore HasAp from Pseudomonas aeruginosa. Biochemistry. 2010;49:6646-54 pubmed publisher
    ..The binding of free hemin is characterized by an initial rapid phase forming an intermediate before further conversion to the final complex...
  10. Sharon E, Freeman R, Willner I. CdSe/ZnS quantum dots-G-quadruplex/hemin hybrids as optical DNA sensors and aptasensors. Anal Chem. 2010;82:7073-7 pubmed publisher
    The luminescence of CdSe/ZnS QDs is quenched via electron transfer by hemin/G-quadruplex associated with the particles...
  11. Lin T, Tang C, Hung S, Liu S, Lin Y, Fu W, et al. Upregulation of heme oxygenase-1 inhibits the maturation and mineralization of osteoblasts. J Cell Physiol. 2010;222:757-68 pubmed publisher
    ..We here used adenoviral vector expressing recombinant human HO-1 and HO-1 inducer hemin to study the effects of HO-1 in primary cultured osteoblasts...
  12. Correa Costa M, Semedo P, Monteiro A, Silva R, Pereira R, Gonçalves G, et al. Induction of heme oxygenase-1 can halt and even reverse renal tubule-interstitial fibrosis. PLoS ONE. 2010;5:e14298 pubmed publisher
    ..male rats were subjected to unilateral ureteral obstruction (UUO) and divided into two groups: non-treated and Hemin-treated. To study the prevention of fibrosis, animals were pre-treated with Hemin at days -2 and -1 prior to UUO...
  13. Fu G, Xu S, Xie Y, Han B, Nie L, Shen W, et al. Molecular cloning, characterization, and expression of an alfalfa (Medicago sativa L.) heme oxygenase-1 gene, MsHO1, which is pro-oxidants-regulated. Plant Physiol Biochem. 2011;49:792-9 pubmed publisher
    ..78 nmol biliverdin-IX? (BV) h?¹ nmol?¹ protein with an apparent Km value for hemin of 2.33 ?M, and the optimum Tm and pH were 37 °C and 7.2, respectively...
  14. Dang T, Robinson S, Dringen R, Bishop G. Uptake, metabolism and toxicity of hemin in cultured neurons. Neurochem Int. 2011;58:804-11 pubmed publisher
    Following hemorrhagic stroke, red blood cells lyse and release neurotoxic hemin into the interstitial space. The present study investigates whether neurons can accumulate and metabolize hemin...
  15. Kuter D, Chibale K, Egan T. Linear free energy relationships predict coordination and ?-stacking interactions of small molecules with ferriprotoporphyrin IX. J Inorg Biochem. 2011;105:684-92 pubmed publisher
  16. Yang X, Fang C, Mei H, Chang T, Cao Z, Shangguan D. Characterization of G-quadruplex/hemin peroxidase: substrate specificity and inactivation kinetics. Chemistry. 2011;17:14475-84 pubmed publisher
    Recently, G-quadruplex/hemin (G4/hemin) complexes have been found to exhibit peroxidase activity, and this feature has been extensively exploited for colorimetric detection of various targets...
  17. Orjih A, Mathew T, Cherian P. Erythrocyte membranes convert monomeric ferriprotoporphyrin IX to ?-hematin in acidic environment at malarial fever temperature. Exp Biol Med (Maywood). 2012;237:884-93 pubmed publisher
    ..b>Hemin in 35% aqueous dimethyl sulfoxide (DMSO) was reacted with isolated erythrocyte membranes and incubated overnight ..
  18. Fang J, Qin H, Seki T, Nakamura H, Tsukigawa K, Shin T, et al. Therapeutic potential of pegylated hemin for reactive oxygen species-related diseases via induction of heme oxygenase-1: results from a rat hepatic ischemia/reperfusion injury model. J Pharmacol Exp Ther. 2011;339:779-89 pubmed publisher
    ..antiapoptotic molecule against intracellular stresses, for its therapeutic potential via its inducer, hemin. To improve the solubility and in vivo pharmacokinetics of hemin for clinical applications, we developed a ..
  19. Dang T, Bishop G, Dringen R, Robinson S. The metabolism and toxicity of hemin in astrocytes. Glia. 2011;59:1540-50 pubmed publisher
    b>Hemin is cytotoxic, and contributes to the brain damage that accompanies hemorrhagic stroke...
  20. Cunnington A, de Souza J, Walther M, Riley E. Malaria impairs resistance to Salmonella through heme- and heme oxygenase-dependent dysfunctional granulocyte mobilization. Nat Med. 2011;18:120-7 pubmed publisher
    ..acute, fatal bacteremia with high bacterial load, features reproduced by phenylhydrazine-induced hemolysis or hemin administration. S. typhimurium localized predominantly in granulocytes...
  21. Jadhav A, Tiwari S, Lee P, Ndisang J. The heme oxygenase system selectively enhances the anti-inflammatory macrophage-M2 phenotype, reduces pericardial adiposity, and ameliorated cardiac injury in diabetic cardiomyopathy in Zucker diabetic fatty rats. J Pharmacol Exp Ther. 2013;345:239-49 pubmed publisher
    ..We investigated the effects of the heme oxygenase (HO) inducer, hemin on pericardial adiposity, macrophage polarization, and diabetic cardiopathy in Zucker diabetic fatty rats (ZDFs) ..
  22. Robinson S, Dang T, Dringen R, Bishop G. Hemin toxicity: a preventable source of brain damage following hemorrhagic stroke. Redox Rep. 2009;14:228-35 pubmed publisher
    ..This secondary damage is partly due to the toxic effects of hemin, a breakdown product of hemoglobin...
  23. Ndisang J, Lane N, Syed N, Jadhav A. Up-regulating the heme oxygenase system with hemin improves insulin sensitivity and glucose metabolism in adult spontaneously hypertensive rats. Endocrinology. 2010;151:549-60 pubmed publisher
    ..Here we report the effects of the HO inducer, hemin, and the HO blocker, chromium-mesoporphyrin on insulin sensitivity and glucose metabolism in SHRs...
  24. von Eiff C, McNamara P, Becker K, Bates D, Lei X, Ziman M, et al. Phenotype microarray profiling of Staphylococcus aureus menD and hemB mutants with the small-colony-variant phenotype. J Bacteriol. 2006;188:687-93 pubmed
    Standard biochemical tests have revealed that hemin and menadione auxotrophic Staphylococcus aureus small-colony variants (SCVs) exhibit multiple phenotypic changes...
  25. Wu J, Lin X, Xie H. Regulation of hemin binding proteins by a novel transcriptional activator in Porphyromonas gingivalis. J Bacteriol. 2009;191:115-22 pubmed publisher
    ..HmuY and HmuR are hemin binding proteins required for P. gingivalis growth...
  26. Sacca P, Meiss R, Casas G, Mazza O, Calvo J, Navone N, et al. Nuclear translocation of haeme oxygenase-1 is associated to prostate cancer. Br J Cancer. 2007;97:1683-9 pubmed
    ..Treatment with hemin, a well-known specific inducer of HO-1, led to clear nuclear localisation of HO-1 in both cell lines and highly ..
  27. Devadas K, Dhawan S. Hemin activation ameliorates HIV-1 infection via heme oxygenase-1 induction. J Immunol. 2006;176:4252-7 pubmed
    b>Hemin, a critical component of hemoglobin, is an active ingredient of a biologic therapeutic approved by the Food and Drug Administration for the treatment of acute porphyries...
  28. Wen J, Huang S, Rogers H, Dickinson L, Kohwi Shigematsu T, Noguchi C. SATB1 family protein expressed during early erythroid differentiation modifies globin gene expression. Blood. 2005;105:3330-9 pubmed
    ..Erythroid differentiation of human erythroleukemia K562 cells by hemin simultaneously increases gamma-globin and down-regulates SATB1 family protein and epsilon-globin gene expression...
  29. Lang D, Reuter S, Buzescu T, August C, Heidenreich S. Heme-induced heme oxygenase-1 (HO-1) in human monocytes inhibits apoptosis despite caspase-3 up-regulation. Int Immunol. 2005;17:155-65 pubmed
    ..We studied the effects of heme oxygenase-1 (HO-1) induced by its substrate hemin on apoptosis, caspase-3 expression and the differentiation of freshly isolated human monocytes...
  30. Asher C, de Villiers K, Egan T. Speciation of ferriprotoporphyrin IX in aqueous and mixed aqueous solution is controlled by solvent identity, pH, and salt concentration. Inorg Chem. 2009;48:7994-8003 pubmed publisher
    ..The findings permit prediction of the Fe(III)PPIX species present in different mixed solvent systems and in the case of aqueous DMSO at any given pH, concentration, and temperature. ..
  31. Ndisang J, Jadhav A. Upregulating the heme oxygenase system suppresses left ventricular hypertrophy in adult spontaneously hypertensive rats for 3 months. J Card Fail. 2009;15:616-28 pubmed publisher
    ..HO-1 was induced with hemin or blocked with chromium mesoporphyrin (CrMP)...
  32. Li B, Du Y, Li T, Dong S. Investigation of 3,3',5,5'-tetramethylbenzidine as colorimetric substrate for a peroxidatic DNAzyme. Anal Chim Acta. 2009;651:234-40 pubmed publisher
    ..sulfate (TMB) as the substrate of a DNAzyme catalytic system composed of a guanine-quadruplex DNA molecule and hemin was investigated...
  33. Norström T, Lannergård J, Hughes D. Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. Antimicrob Agents Chemother. 2007;51:4438-46 pubmed
    ..FusA-SCVs are auxotrophic for hemin. A second class of FA-resistant SCVs carry mutations in rplF, coding for ribosomal protein L6, and are designated ..
  34. Jadhav A, Torlakovic E, Ndisang J. Hemin therapy attenuates kidney injury in deoxycorticosterone acetate-salt hypertensive rats. Am J Physiol Renal Physiol. 2009;296:F521-34 pubmed publisher
    ..In this study, the administration of the HO inducer hemin lowered blood pressure (191 vs. 135 mmHg; n = 22, P < 0...
  35. Di Filippo C, Marfella R, Cuzzocrea S, Piegari E, Petronella P, Giugliano D, et al. Hyperglycemia in streptozotocin-induced diabetic rat increases infarct size associated with low levels of myocardial HO-1 during ischemia/reperfusion. Diabetes. 2005;54:803-10 pubmed
    ..The effects of 1) hemin, an inducer of HO expression and activity, and 2) zinc protoporphyrin IX (ZnPP-IX), an inhibitor of HO activity, ..
  36. Kumar S, Bandyopadhyay U. Free heme toxicity and its detoxification systems in human. Toxicol Lett. 2005;157:175-88 pubmed
    ..A brief account of free heme toxicity and its detoxification systems along with mechanistic details are presented. ..
  37. Chok M, Ferlicot S, Conti M, Almolki A, Durrbach A, Loric S, et al. Renoprotective potency of heme oxygenase-1 induction in rat renal ischemia-reperfusion. Inflamm Allergy Drug Targets. 2009;8:252-9 pubmed
    ..Rats were injected intraperitoneally with either: 50 mg/kg hemin (HO-1 inducer groups: H1, H2); 50 micromol/kg ZnPP (HO-1 inhibitor groups: Hz1, Hz2); or 0...
  38. Mosén H, Salehi A, Alm P, Henningsson R, Jimenez Feltstrom J, Ostenson C, et al. Defective glucose-stimulated insulin release in the diabetic Goto-Kakizaki (GK) rat coincides with reduced activity of the islet carbon monoxide signaling pathway. Endocrinology. 2005;146:1553-8 pubmed
    ..Addition of the HO activator hemin or gaseous CO to the incubation media brought about a similar amplification of glucose-stimulated insulin release ..
  39. Omodeo Salè F, Cortelezzi L, Riva E, Vanzulli E, Taramelli D. Modulation of glyceraldehyde 3 phosphate dehydrogenase activity and tyr-phosphorylation of Band 3 in human erythrocytes treated with ferriprotoporphyrin IX. Biochem Pharmacol. 2007;74:1383-9 pubmed
  40. Xue H, Guo H, Li Y, Hao Z. Heme oxygenase-1 induction by hemin protects liver cells from ischemia/reperfusion injury in cirrhotic rats. World J Gastroenterol. 2007;13:5384-90 pubmed
    ..into 5 groups as follows: normal (N) group; liver cirrhotic (LC) group; sham (S) group; I/R group and I/R + hemin group. The model for inducing liver cirrhosis in rats was established according to a previously published protocol...
  41. Xia Z, Li C, Jin Y, Shi Y, Xu L, Zhong W, et al. Reduction of bilirubin by targeting human heme oxygenase-1 through siRNA. Exp Biol Med (Maywood). 2007;232:495-502 pubmed
    ..In addition, the inhibitory effect of siRNA on hHO-1 was assessed in cells treated with hemin or transfected with an hHO-1 plasmid. siRNA-C showed the most potent suppressive effect on hHO-1...
  42. Lakkisto P, Csonka C, Fodor G, Bencsik P, Voipio Pulkki L, Ferdinandy P, et al. The heme oxygenase inducer hemin protects against cardiac dysfunction and ventricular fibrillation in ischaemic/reperfused rat hearts: role of connexin 43. Scand J Clin Lab Invest. 2009;69:209-18 pubmed publisher
    ..We therefore hypothesized that pretreatment with hemin, an inductor of HO-1, would precondition the heart against post-ischaemic dysfunction and ventricular fibrillation ..
  43. Ndisang J, Lane N, Jadhav A. Crosstalk between the heme oxygenase system, aldosterone, and phospholipase C in hypertension. J Hypertens. 2008;26:1188-99 pubmed publisher
    ..In the present study, the heme oxygenase inducer, hemin, was given to spontaneously hypertensive and deoxycorticosterone acetate hypertensive rats, and the effects on ..
  44. Al Qutub M, Braham P, Karimi Naser L, Liu X, Genco C, Darveau R. Hemin-dependent modulation of the lipid A structure of Porphyromonas gingivalis lipopolysaccharide. Infect Immun. 2006;74:4474-85 pubmed
    ..In this report, it is shown that the concentration of hemin in the growth medium significantly modulates the lipopolysaccharide lipid A structural content of P. gingivalis...
  45. Kiyama Kishikawa M, Hiratsuka K, Abiko Y. Gene expression profiling and characterization under hemin limitation in Porphyromonas gingivalis. J Oral Sci. 2005;47:191-7 pubmed
    b>Hemin is an important nutrient for Porphyromonas gingivalis growth and pathogenicity. We examined the gene expression profile of P...
  46. Tsiftsoglou A, Tsamadou A, Papadopoulou L. Heme as key regulator of major mammalian cellular functions: molecular, cellular, and pharmacological aspects. Pharmacol Ther. 2006;111:327-45 pubmed
    ..b>Hemin (the oxidized form of iron protoporphyrin IX) on the other hand is an essential regulator of gene expression and ..
  47. Tsoyi K, Lee T, Lee Y, Kim H, Seo H, Lee J, et al. Heme-oxygenase-1 induction and carbon monoxide-releasing molecule inhibit lipopolysaccharide (LPS)-induced high-mobility group box 1 release in vitro and improve survival of mice in LPS- and cecal ligation and puncture-induced sepsis model in vivo. Mol Pharmacol. 2009;76:173-82 pubmed publisher
    ..We found that pretreatment with HO-1 inducers (hemin, cobalt protoporphyrin IX) or transfection of HO-1 significantly inhibited HMGB1 release, which was blocked by HO-..
  48. Omodeo Salè F, Motti A, Dondorp A, White N, Taramelli D. Destabilisation and subsequent lysis of human erythrocytes induced by Plasmodium falciparum haem products. Eur J Haematol. 2005;74:324-32 pubmed
    ..These changes could contribute to the reduced red cell deformability associated with severe malaria. ..
  49. Ndisang J, Jadhav A. Heme oxygenase system enhances insulin sensitivity and glucose metabolism in streptozotocin-induced diabetes. Am J Physiol Endocrinol Metab. 2009;296:E829-41 pubmed publisher
    ..HO was upregulated with hemin (15 mg/kg ip) or inhibited with chromium mesoporphyrin (CrMP, 4 micromol/kg ip)...
  50. Kim J, Yang J, Jung M, Hwa J, Kang K, Kang K, et al. Heme oxygenase-1 protects rat kidney from ureteral obstruction via an antiapoptotic pathway. J Am Soc Nephrol. 2006;17:1373-81 pubmed
    ..which unilateral ureteral obstruction (UUO) was performed: untreated (group 1), treated with 30 mg/kg body wt hemin (group 2), and treated with 50 microg/kg body wt zinc (alpha) protoporphyrin eta (ZnPP) and 30 mg/kg hemin (group ..
  51. Datla S, Dusting G, Mori T, Taylor C, Croft K, Jiang F. Induction of heme oxygenase-1 in vivo suppresses NADPH oxidase derived oxidative stress. Hypertension. 2007;50:636-42 pubmed
    ..In this study, we examined the consequence of HO-1 induction in vivo on NADPH oxidase activity. Three doses of hemin (25 mg x kg(-1), IP, every 48 hours), with or without cotreatment with the HO inhibitor tin protoporphyrin-IX (15 ..
  52. Li T, Dong S, Wang E. Label-free colorimetric detection of aqueous mercury ion (Hg2+) using Hg2+-modulated G-quadruplex-based DNAzymes. Anal Chem. 2009;81:2144-9 pubmed publisher
    ..These G-quadruplex DNAs are able to bind hemin to form the peroxidase-like DNAzymes in the folded state...
  53. Gatidis S, Foller M, Lang F. Hemin-induced suicidal erythrocyte death. Ann Hematol. 2009;88:721-6 pubmed publisher
    Several diseases, such as malaria, sickle cell disease, and ischemia/reperfusion may cause excessive formation of hemin, which may in turn trigger hemolysis...