Summary: Biological adaptation, such as the rise of EPINEPHRINE in response to exercise, stress or perceived danger, followed by a fall of epinephrine during RELAXATION. Allostasis is the achievement of stability by turning on and turning off the allostatic systems including the IMMUNE SYSTEM; the AUTONOMIC NERVOUS SYSTEM and NEUROENDOCRINE SYSTEMS.

Top Publications

  1. McEwen B, Wingfield J. What is in a name? Integrating homeostasis, allostasis and stress. Horm Behav. 2010;57:105-11 pubmed publisher
  2. Van Houdenhove B, Luyten P. Central sensitivity syndromes: stress system failure may explain the whole picture. Semin Arthritis Rheum. 2009;39:218-9; author reply 220-1 pubmed publisher
  3. Baldin E, Hauser W, PACK A, Hesdorffer D. Stress is associated with an increased risk of recurrent seizures in adults. Epilepsia. 2017;58:1037-1046 pubmed publisher
    ..Stress-reducing interventions, such as mindfulness, may be a useful, safe, and inexpensive adjunctive treatment for epilepsy. ..
  4. Tegeler C, Cook J, Tegeler C, Hirsch J, Shaltout H, Simpson S, et al. Clinical, hemispheric, and autonomic changes associated with use of closed-loop, allostatic neurotechnology by a case series of individuals with self-reported symptoms of post-traumatic stress. BMC Psychiatry. 2017;17:141 pubmed publisher #NCT02709369 , retrospectively registered on March 4, 2016. ..
  5. Bruce M, Martins D, Duru K, Beech B, Sims M, Harawa N, et al. Church attendance, allostatic load and mortality in middle aged adults. PLoS ONE. 2017;12:e0177618 pubmed publisher
    ..AL, a measure of stress, only partially explained differences in mortality between church and non-church attendees. These findings suggest a potential independent effect of church attendance on mortality. ..
  6. Egorov A, Griffin S, Converse R, Styles J, Sams E, Wilson A, et al. Vegetated land cover near residence is associated with reduced allostatic load and improved biomarkers of neuroendocrine, metabolic and immune functions. Environ Res. 2017;158:508-521 pubmed publisher
    ..The observed effects of vegetated land cover on allostatic load and individual biomarkers are consistent with prevention of depression, cardiovascular disease and premature mortality. ..
  7. Gray J, Kogan J, Marrocco J, McEwen B. Genomic and epigenomic mechanisms of glucocorticoids in the brain. Nat Rev Endocrinol. 2017;13:661-673 pubmed publisher
    ..Glucocorticoids are essential for adaptation to stressors (allostasis) and in maladaptation resulting from allostatic load and overload...
  8. Barr D. The Childhood Roots of Cardiovascular Disease Disparities. Mayo Clin Proc. 2017;92:1415-1421 pubmed publisher
  9. Coplan J, Gupta N, Karim A, Rozenboym A, Smith E, Kral J, et al. Maternal hypothalamic-pituitary-adrenal axis response to foraging uncertainty: A model of individual vs. social allostasis and the "Superorganism Hypothesis". PLoS ONE. 2017;12:e0184340 pubmed publisher
    ..adaptations of the HPA axis may subserve second-order homeostasis, a process we provisionally term "social allostasis." We postulate that maternal food insecurity induces a "superorganism" state through coordination of individual ..

More Information


  1. Kobrosly R, van Wijngaarden E, Seplaki C, Cory Slechta D, Moynihan J. Depressive symptoms are associated with allostatic load among community-dwelling older adults. Physiol Behav. 2014;123:223-30 pubmed
    ..Future research should examine the inter-relationships of allostatic load, psychological stress, and late-life depressive symptoms. ..
  2. Sterling P. Homeostasis vs allostasis: implications for brain function and mental disorders. JAMA Psychiatry. 2014;71:1192-3 pubmed publisher
  3. Rubinow K, Rubinow D. In immune defense: redefining the role of the immune system in chronic disease. Dialogues Clin Neurosci. 2017;19:19-26 pubmed
    ..By invoking allostasis or systems biology rather than inflammation, we can ascribe greater functional significance to immune mediators, ..
  4. Smith C, Nehrke K, Brookes P. The Slo(w) path to identifying the mitochondrial channels responsible for ischemic protection. Biochem J. 2017;474:2067-2094 pubmed publisher
  5. Yadav V, Gao X, Willard B, Hatzoglou M, Banerjee R, Kabil O. Hydrogen sulfide modulates eukaryotic translation initiation factor 2? (eIF2?) phosphorylation status in the integrated stress-response pathway. J Biol Chem. 2017;292:13143-13153 pubmed publisher
    ..Although a transient increase in endogenous H2S production provides cytoprotection, its chronic increase such as in cystathionine ?-synthase deficiency may pose a problem. ..
  6. Qureshi M, Haynes C, Pellegrino M. The mitochondrial unfolded protein response: Signaling from the powerhouse. J Biol Chem. 2017;292:13500-13506 pubmed publisher
    ..Furthermore, we will explore the current repertoire of biological functions that are associated with this essential stress-response pathway. ..
  7. Robertson T, Beveridge G, Bromley C. Allostatic load as a predictor of all-cause and cause-specific mortality in the general population: Evidence from the Scottish Health Survey. PLoS ONE. 2017;12:e0183297 pubmed publisher