Summary: Biological adaptation, such as the rise of EPINEPHRINE in response to exercise, stress or perceived danger, followed by a fall of epinephrine during RELAXATION. Allostasis is the achievement of stability by turning on and turning off the allostatic systems including the IMMUNE SYSTEM; the AUTONOMIC NERVOUS SYSTEM and NEUROENDOCRINE SYSTEMS.
- Kobrosly R, van Wijngaarden E, Seplaki C, Cory Slechta D, Moynihan J. Depressive symptoms are associated with allostatic load among community-dwelling older adults. Physiol Behav. 2014;123:223-30 pubmed..Future research should examine the inter-relationships of allostatic load, psychological stress, and late-life depressive symptoms. ..
- Rubinow K, Rubinow D. In immune defense: redefining the role of the immune system in chronic disease. Dialogues Clin Neurosci. 2017;19:19-26 pubmed..By invoking allostasis or systems biology rather than inflammation, we can ascribe greater functional significance to immune mediators, ..
- Yadav V, Gao X, Willard B, Hatzoglou M, Banerjee R, Kabil O. Hydrogen sulfide modulates eukaryotic translation initiation factor 2? (eIF2?) phosphorylation status in the integrated stress-response pathway. J Biol Chem. 2017;292:13143-13153 pubmed publisher..Although a transient increase in endogenous H2S production provides cytoprotection, its chronic increase such as in cystathionine ?-synthase deficiency may pose a problem. ..
- Qureshi M, Haynes C, Pellegrino M. The mitochondrial unfolded protein response: Signaling from the powerhouse. J Biol Chem. 2017;292:13500-13506 pubmed publisher..Furthermore, we will explore the current repertoire of biological functions that are associated with this essential stress-response pathway. ..