b7 antigens


Summary: A family of cell-surface proteins found on ANTIGEN-PRESENTING CELLS. B7 antigens are ligands for specific cell surface receptor subtypes found on T-CELLS. They play an immunomodulatory role by stimulating or inhibiting the T-CELL activation process.

Top Publications

  1. Peake S, Bernardo D, Mann E, Al Hassi H, Knight S, Hart A. Infliximab induces a dysregulated tissue-homing profile on human T-lymphocytes in-vitro: a novel mechanism for paradoxical inflammation?. J Crohns Colitis. 2013;7:765-7 pubmed publisher
  2. Hu Y, Lv X, Wu Y, Xu J, Wang L, Chen W, et al. Expression of costimulatory molecule B7-H3 and its prognostic implications in human acute leukemia. Hematology. 2015;20:187-95 pubmed publisher
    ..Owing to the expression of B7-H3 being statistically relevant in predicting disease progression and a shorter life survival, our results demonstrated that B7-H3 expression in acute leukemia predicts an unfavorable outcome. ..
  3. Park J, Cheung N. Limitations and opportunities for immune checkpoint inhibitors in pediatric malignancies. Cancer Treat Rev. 2017;58:22-33 pubmed publisher
    ..In addition, we will discuss immunologic and clinical difficulties in this young population, as well as future prospects for combination of ICI with other immune-based and conventional treatments. ..
  4. Al Sukaini A, Hornicek F, Peacock Z, Kaban L, Ferrone S, Schwab J. Immune Surveillance Plays a Role in Locally Aggressive Giant Cell Lesions of Bone. Clin Orthop Relat Res. 2017;475:3071-3081 pubmed publisher
    ..Failure of immune surveillance implies that there may be an opportunity to target aspects of the immune surveillance machinery to treat giant cell lesions. ..
  5. Watanabe M, Fujihara C, Radtke A, Chiang Y, Bhatia S, Germain R, et al. Co-stimulatory function in primary germinal center responses: CD40 and B7 are required on distinct antigen-presenting cells. J Exp Med. 2017;214:2795-2810 pubmed publisher
  6. Chen X, Meng X, Foley N, Shi X, Liu M, Chai Y, et al. Activation of the TLR2-mediated downstream signaling pathways NF-?B and MAPK is responsible for B7-H3-augmented inflammatory response during S. pneumoniae infection. J Neuroimmunol. 2017;310:82-90 pubmed publisher
    ..pneumoniae-infected mice. These results indicate that the activation of both NF-?B and MAPKs is predominantly responsible for B7-H3-augmented inflammatory response during S. pneumoniae infection. ..
  7. Flies D, Han X, Higuchi T, Zheng L, Sun J, Ye J, et al. Coinhibitory receptor PD-1H preferentially suppresses CD4? T cell-mediated immunity. J Clin Invest. 2014;124:1966-75 pubmed publisher
    ..Together, our findings suggest that PD-1H has potential as a target of immune modulation in the treatment of human inflammation and malignancies. ..
  8. Li M, Beauchemin H, Popovic N, Peterson A, d Hennezel E, Piccirillo C, et al. The common, autoimmunity-predisposing 620Arg > Trp variant of PTPN22 modulates macrophage function and morphology. J Autoimmun. 2017;79:74-83 pubmed publisher
    ..Our model shows no alteration in immune cell profile by the Trp allele, but brings up macrophages as an important player to consider in explaining the PTPN22 Trp allele effect on autoimmune disease risk. ..
  9. Eichmüller S, Osen W, Mandelboim O, Seliger B. Immune Modulatory microRNAs Involved in Tumor Attack and Tumor Immune Escape. J Natl Cancer Inst. 2017;109: pubmed publisher
    ..This review focuses on the characterization of miRNAs involved in the regulation of immune surveillance or immune escape of tumors and their potential use as diagnostic and prognostic biomarkers or as therapeutic targets. ..

More Information


  1. Zhang P, Chen Z, Ning K, Jin J, Han X. Inhibition of B7-H3 reverses oxaliplatin resistance in human colorectal cancer cells. Biochem Biophys Res Commun. 2017;490:1132-1138 pubmed publisher
    ..Finally, the upregulation of XRCC1 expression induced by B7-H3 involved PI3K-AKT pathway. In conclusion, B7-H3 promotes the oxaliplatin resistance in CRC cells upregulating the expression of XRCC1 via PI3K-AKT pathway. ..