arrestin

Summary

Summary: A 48-Kd protein of the outer segment of the retinal rods and a component of the phototransduction cascade. Arrestin quenches G-protein activation by binding to phosphorylated photolyzed rhodopsin. Arrestin causes experimental autoimmune uveitis when injected into laboratory animals.

Top Publications

  1. Battelle B, Dabdoub A, Malone M, Andrews A, Cacciatore C, Calman B, et al. Immunocytochemical localization of opsin, visual arrestin, myosin III, and calmodulin in Limulus lateral eye retinular cells and ventral photoreceptors. J Comp Neurol. 2001;435:211-25 pubmed
    ..We developed antibodies directed against Limulus opsin, visual arrestin, and myosin III, and we have used them to examine the distributions of these proteins in the Limulus visual ..
  2. Patwari P, Chutkow W, Cummings K, Verstraeten V, Lammerding J, Schreiter E, et al. Thioredoxin-independent regulation of metabolism by the alpha-arrestin proteins. J Biol Chem. 2009;284:24996-5003 pubmed publisher
    ..Txnip is a member of the alpha-arrestin protein family; the alpha-arrestins are related to the classical beta-arrestins and visual arrestins...
  3. Dalrymple M, Jaeger W, Eidne K, Pfleger K. Temporal profiling of orexin receptor-arrestin-ubiquitin complexes reveals differences between receptor subtypes. J Biol Chem. 2011;286:16726-33 pubmed publisher
    ..agonist-occupied OxRs provided evidence for a strong dose-dependent interaction with both trafficking proteins ?-arrestin 1 and 2 that required unusually high agonist concentrations compared with inositol phosphate signaling...
  4. Roca A, Shin K, Liu X, Simon M, Chen J. Comparative analysis of transcriptional profiles between two apoptotic pathways of light-induced retinal degeneration. Neuroscience. 2004;129:779-90 pubmed
    ..models have revealed two independent apoptotic pathways: low levels of light induce retinal degeneration in the arrestin -/- mouse via constitutive activation of the phototransduction cascade, whereas strong light exposure to the ..
  5. Kirchberg K, Kim T, M ller M, Skegro D, Dasara Raju G, Granzin J, et al. Conformational dynamics of helix 8 in the GPCR rhodopsin controls arrestin activation in the desensitization process. Proc Natl Acad Sci U S A. 2011;108:18690-5 pubmed publisher
    ..In visual rhodopsin, selective binding of arrestin to the cytoplasmic side of light-activated, phosphorylated rhodopsin (P-Rh*) terminates signaling via the G-..
  6. Hanson S, Gurevich E, Vishnivetskiy S, Ahmed M, Song X, Gurevich V. Each rhodopsin molecule binds its own arrestin. Proc Natl Acad Sci U S A. 2007;104:3125-8 pubmed
    ..Thus, a single Rh molecule is necessary and sufficient to bind Arr. Remarkable structural conservation among receptors and Arrs strongly suggests that all Arr subtypes bind individual molecules of their cognate receptors. ..
  7. Becuwe M, Vieira N, Lara D, Gomes Rezende J, Soares Cunha C, Casal M, et al. A molecular switch on an arrestin-like protein relays glucose signaling to transporter endocytosis. J Cell Biol. 2012;196:247-59 pubmed publisher
    ..We show that this required the conserved arrestin-related protein Rod1/Art4, which was activated in response to glucose addition...
  8. Ascano M, Smith W, Gregurick S, Robinson P. Arrestin residues involved in the functional binding of arrestin to phosphorylated, photolyzed rhodopsin. Mol Vis. 2006;12:1516-25 pubmed
    The purpose of our study was to determine whether arrestin residues previously predicted by computational modeling to interact with an aspartic acid substituted rhodopsin tail are actually involved in interactions with phospho-residues on ..
  9. Zhu X, Li A, Brown B, Weiss E, Osawa S, Craft C. Mouse cone arrestin expression pattern: light induced translocation in cone photoreceptors. Mol Vis. 2002;8:462-71 pubmed
    ..Cone arrestin (CAR) is expressed in cone photoreceptors and pinealocytes and may contribute to the shutoff mechanisms ..

More Information

Publications80

  1. Song X, Vishnivetskiy S, Gross O, Emelianoff K, Mendez A, Chen J, et al. Enhanced arrestin facilitates recovery and protects rods lacking rhodopsin phosphorylation. Curr Biol. 2009;19:700-5 pubmed publisher
    ..signaling, including rhodopsin-driven phototransduction, is terminated by receptor phosphorylation followed by arrestin binding [2]...
  2. Groer C, Tidgewell K, Moyer R, Harding W, Rothman R, Prisinzano T, et al. An opioid agonist that does not induce mu-opioid receptor--arrestin interactions or receptor internalization. Mol Pharmacol. 2007;71:549-57 pubmed
    ..For example, morphine binding produces a muOR with low affinity for beta-arrestin proteins and limited receptor internalization, whereas enkephalin analogs promote robust trafficking of both beta-..
  3. Goodman O, Krupnick J, Gurevich V, Benovic J, Keen J. Arrestin/clathrin interaction. Localization of the arrestin binding locus to the clathrin terminal domain. J Biol Chem. 1997;272:15017-22 pubmed
    ..a short sequence of highly conserved residues within the globular clathrin terminal domain is responsible for arrestin binding...
  4. Bowen Pidgeon D, Innamorati G, Sadeghi H, Birnbaumer M. Arrestin effects on internalization of vasopressin receptors. Mol Pharmacol. 2001;59:1395-401 pubmed
    ..Coexpression of the V1a or V2 receptors with the last 100 amino acids of arrestin reduced significantly their internalization, whereas coexpression of wild-type and mutant arrestins had diverse ..
  5. Haberstock Debic H, Kim K, Yu Y, von Zastrow M. Morphine promotes rapid, arrestin-dependent endocytosis of mu-opioid receptors in striatal neurons. J Neurosci. 2005;25:7847-57 pubmed
    ..and endocytosis induced by both ligands was inhibited by a dominant-negative mutant version of arrestin-3 (beta-arrestin-2)...
  6. Mani S, Besharse J, Knox B. Immediate upstream sequence of arrestin directs rod-specific expression in Xenopus. J Biol Chem. 1999;274:15590-7 pubmed
    Arrestins are a family of proteins that modulate G protein-coupled receptor responses with distinct arrestin genes expressed in rods and cones...
  7. Caunt C, Finch A, Sedgley K, Oakley L, Luttrell L, McArdle C. Arrestin-mediated ERK activation by gonadotropin-releasing hormone receptors: receptor-specific activation mechanisms and compartmentalization. J Biol Chem. 2006;281:2701-10 pubmed
    Activation of seven-transmembrane region receptors typically causes their phosphorylation with consequent arrestin binding and desensitization...
  8. Hanson S, Gurevich V. The differential engagement of arrestin surface charges by the various functional forms of the receptor. J Biol Chem. 2006;281:3458-62 pubmed
    G-protein-coupled receptor signaling is terminated by arrestin proteins that preferentially bind to the activated phosphorylated form of the receptor. Arrestins also bind active unphosphorylated and inactive phosphorylated receptors...
  9. Song X, Gurevich E, Gurevich V. Cone arrestin binding to JNK3 and Mdm2: conformational preference and localization of interaction sites. J Neurochem. 2007;103:1053-62 pubmed
    ..The functions of free arrestins are poorly understood, and the interaction sites of the non-receptor arrestin partners are largely unknown...
  10. Chuang J, Vega C, Jun W, Sung C. Structural and functional impairment of endocytic pathways by retinitis pigmentosa mutant rhodopsin-arrestin complexes. J Clin Invest. 2004;114:131-40 pubmed
    ..g., R135L, R135G, and R135W) are hyperphosphorylated and bind with high affinity to visual arrestin. Mutant rhodopsin recruits the cytosolic arrestin to the plasma membrane, and the rhodopsin-arrestin complex is ..
  11. Liu C, Satoh A, Postma M, Huang J, Ready D, Hardie R. Ca2+-dependent metarhodopsin inactivation mediated by calmodulin and NINAC myosin III. Neuron. 2008;59:778-89 pubmed publisher
    ..Ca2+ dependence of M( *) inactivation was unaffected by mutations affecting phosphorylation of rhodopsin or arrestin but was abolished in mutants of calmodulin (CaM) or the CaM-binding myosin III, NINAC...
  12. Guetta D, Langou K, Grunwald D, Klein G, Aubry L. FYVE-dependent endosomal targeting of an arrestin-related protein in amoeba. PLoS ONE. 2010;5:e15249 pubmed publisher
    ..The arrestin superfamilly includes several arrestin domain-containing proteins and the structurally related protein Vps26...
  13. Chen J, Shi G, Concepcion F, Xie G, Oprian D, Chen J. Stable rhodopsin/arrestin complex leads to retinal degeneration in a transgenic mouse model of autosomal dominant retinitis pigmentosa. J Neurosci. 2006;26:11929-37 pubmed
    ..We show that K296E, a rhodopsin mutation associated with ADRP, forms a stable complex with arrestin that is toxic to mouse rod photoreceptors. This cell death pathway appears to be conserved from flies to mammals...
  14. Vishnivetskiy S, Hosey M, Benovic J, Gurevich V. Mapping the arrestin-receptor interface. Structural elements responsible for receptor specificity of arrestin proteins. J Biol Chem. 2004;279:1262-8 pubmed
    Arrestins selectively bind to phosphorylated activated forms of their cognate G protein-coupled receptors. Arrestin binding prevents further G protein activation and often redirects signaling to other pathways...
  15. Smith W, Dinculescu A, Peterson J, McDowell J. The surface of visual arrestin that binds to rhodopsin. Mol Vis. 2004;10:392-8 pubmed
    The binding of visual arrestin to phosphorylated, activated rhodopsin serves as a model for studying the inactivation process of a large class of G-protein coupled receptor systems...
  16. Hanson S, Francis D, Vishnivetskiy S, Kolobova E, Hubbell W, Klug C, et al. Differential interaction of spin-labeled arrestin with inactive and active phosphorhodopsin. Proc Natl Acad Sci U S A. 2006;103:4900-5 pubmed
    ..To identify sites in arrestin involved in receptor interaction, a nitroxide-containing side chain was introduced at each of 28 different ..
  17. Bhatnagar A, Willins D, Gray J, Woods J, Benovic J, Roth B. The dynamin-dependent, arrestin-independent internalization of 5-hydroxytryptamine 2A (5-HT2A) serotonin receptors reveals differential sorting of arrestins and 5-HT2A receptors during endocytosis. J Biol Chem. 2001;276:8269-77 pubmed
    ..The mechanisms responsible for this paradoxical regulation of 5-HT2A receptors are unknown. In this study, the arrestin and dynamin dependences of agonist- and antagonist-mediated internalization were investigated in live cells using ..
  18. Kang D, Kern R, Puthenveedu M, von Zastrow M, Williams J, Benovic J. Structure of an arrestin2-clathrin complex reveals a novel clathrin binding domain that modulates receptor trafficking. J Biol Chem. 2009;284:29860-72 pubmed publisher
    ..Although arrestin interaction with clathrin, AP-2, and phosphoinositides contributes to receptor trafficking, little is known about ..
  19. Oakley R, Hudson C, Sjaastad M, Loomis C. The ligand-independent translocation assay: an enabling technology for screening orphan G protein-coupled receptors by arrestin recruitment. Methods Enzymol. 2006;414:50-63 pubmed
    ..Transfluor is a cell-based GPCR screening platform that utilizes an arrestin-green fluorescent protein conjugate (arrestin-GFP) to detect ligand interactions with GPCRs...
  20. Hayashi T, Gekka T, Takeuchi T, Goto Omoto S, Kitahara K. A novel homozygous GRK1 mutation (P391H) in 2 siblings with Oguchi disease with markedly reduced cone responses. Ophthalmology. 2007;114:134-41 pubmed
    ..disease, a rare form of stationary night blindness with autosomal recessive transmission, have been in the SAG (arrestin) gene...
  21. Gurevich V. The selectivity of visual arrestin for light-activated phosphorhodopsin is controlled by multiple nonredundant mechanisms. J Biol Chem. 1998;273:15501-6 pubmed
    b>Arrestin plays an important role in quenching phototransduction via its ability to bind to the phosphorylated light-activated form of the visual receptor rhodopsin (P-Rh*)...
  22. Bennett T, Foutz T, Gurevich V, Sklar L, Prossnitz E. Partial phosphorylation of the N-formyl peptide receptor inhibits G protein association independent of arrestin binding. J Biol Chem. 2001;276:49195-203 pubmed
    ..Furthermore, whereas stimulated wild type FPR in whole cells colocalizes with arrestin-2, and the solubilized, phosphorylated FPR binds arrestin-2, the stimulated receptors lacking four potential ..
  23. Peet J, Bragin A, Calvert P, Nikonov S, Mani S, Zhao X, et al. Quantification of the cytoplasmic spaces of living cells with EGFP reveals arrestin-EGFP to be in disequilibrium in dark adapted rod photoreceptors. J Cell Sci. 2004;117:3049-59 pubmed
    ..In contrast, the fluorescence of soluble arrestin-EGFP fusion protein in the dark adapted rod outer segment was approximately threefold lower than predicted by the ..
  24. Bryceson Y, Ljunggren H. Arrestin NK cell cytotoxicity. Nat Immunol. 2008;9:835-6 pubmed publisher
  25. Gehret A, Hinkle P. Importance of regions outside the cytoplasmic tail of G-protein-coupled receptors for phosphorylation and dephosphorylation. Biochem J. 2010;428:235-45 pubmed publisher
    ..TRHR co-internalizes with arrestin, whereas beta(2)AR recruits arrestin, but internalizes without it...
  26. Mundell S, Matharu A, Nisar S, Palmer T, Benovic J, Kelly E. Deletion of the distal COOH-terminus of the A2B adenosine receptor switches internalization to an arrestin- and clathrin-independent pathway and inhibits recycling. Br J Pharmacol. 2010;159:518-33 pubmed publisher
    ..Expression of dominant negative mutants of arrestin-2, dynamin or Eps-15 inhibited internalization of wild type and Leu(330)-stop receptors, whereas only dominant ..
  27. Ahmed M, Zhan X, Song X, Kook S, Gurevich V, Gurevich E. Ubiquitin ligase parkin promotes Mdm2-arrestin interaction but inhibits arrestin ubiquitination. Biochemistry. 2011;50:3749-63 pubmed publisher
    ..Here we show that parkin binds arrestins, versatile regulators of cell signaling. Arrestin-parkin interaction was demonstrated by coimmunoprecipitation of endogenous proteins from brain tissue and shown ..
  28. Liu Q, Dewi D, Liu W, Bee M, Schonbrunn A. Distinct phosphorylation sites in the SST2A somatostatin receptor control internalization, desensitization, and arrestin binding. Mol Pharmacol. 2008;73:292-304 pubmed
    ..In both the wild-type and Ser- receptors, agonist binding produced a stable arrestin-receptor complex that was maintained during receptor trafficking, whereas arrestin was not recruited to either ..
  29. Sinha A, Jones Brunette A, Fay J, Schafer C, Farrens D. Rhodopsin TM6 can interact with two separate and distinct sites on arrestin: evidence for structural plasticity and multiple docking modes in arrestin-rhodopsin binding. Biochemistry. 2014;53:3294-307 pubmed publisher
    Various studies have implicated the concave surface of arrestin in the binding of the cytosolic surface of rhodopsin. However, specific sites of contact between the two proteins have not previously been defined in detail...
  30. Orisme W, Li J, Goldmann T, Bolch S, Wolfrum U, Smith W. Light-dependent translocation of arrestin in rod photoreceptors is signaled through a phospholipase C cascade and requires ATP. Cell Signal. 2010;22:447-56 pubmed publisher
    ..In rod photoreceptors, light induces a large-scale translocation of arrestin from the inner segments to the outer segments...
  31. Shi H, Rojas R, Bonifacino J, Hurley J. The retromer subunit Vps26 has an arrestin fold and binds Vps35 through its C-terminal domain. Nat Struct Mol Biol. 2006;13:540-8 pubmed
    ..Hydrophobic residues and a glycine in this loop are required for integration into the retromer complex and endosomal localization of human Vps26, and for the function of yeast Vps26 in carboxypeptidase Y sorting. ..
  32. Sippel K, DeStefano J, Berson E, Dryja T. Evaluation of the human arrestin gene in patients with retinitis pigmentosa and stationary night blindness. Invest Ophthalmol Vis Sci. 1998;39:665-70 pubmed
    To establish the DNA sequence of the coding regions of the human arrestin locus and to determine whether defects in this sequence are present among patients with retinitis pigmentosa (RP) or types of stationary night blindness in addition ..
  33. Suhler E, Chan C, Caruso R, Schrump D, Thirkill C, Smith J, et al. Presumed teratoma-associated paraneoplastic retinopathy. Arch Ophthalmol. 2003;121:133-7 pubmed
  34. Shi G, Chen J, Concepcion F, Motamedchaboki K, Marjoram P, Langen R, et al. Light causes phosphorylation of nonactivated visual pigments in intact mouse rod photoreceptor cells. J Biol Chem. 2005;280:41184-91 pubmed
    ..The second mouse model expressed the constitutively active human opsin mutant K296E. K296E, in the arrestin-/- background, also led to phosphorylation of endogenous mouse rhodopsin in the dark-adapted retina...
  35. Nisar S, Cunningham M, Saxena K, Pope R, Kelly E, Mundell S. Arrestin scaffolds NHERF1 to the P2Y12 receptor to regulate receptor internalization. J Biol Chem. 2012;287:24505-15 pubmed publisher
    ..interacts directly with the receptor but instead binds to the receptor via the endocytic scaffolding protein arrestin. These findings suggest a novel model by which arrestin can serve as an adaptor to promote NHERF1 interaction ..
  36. Pan L, Gurevich E, Gurevich V. The nature of the arrestin x receptor complex determines the ultimate fate of the internalized receptor. J Biol Chem. 2003;278:11623-32 pubmed
    ..receptors are desensitized by a uniform two-step mechanism: phosphorylation of an active receptor followed by arrestin binding. The arrestin x receptor complex is then internalized...
  37. Kimura T, Han W, Pagel P, Nairn A, Caplan M. Protein phosphatase 2A interacts with the Na,K-ATPase and modulates its trafficking by inhibition of its association with arrestin. PLoS ONE. 2011;6:e29269 pubmed publisher
    ..PP2A inhibits association between the Na?,K?-ATPase and arrestin, and diminishes the effect of arrestin on Na?,K?-ATPase trafficking...
  38. Lin C, MacGurn J, Chu T, Stefan C, Emr S. Arrestin-related ubiquitin-ligase adaptors regulate endocytosis and protein turnover at the cell surface. Cell. 2008;135:714-25 pubmed publisher
    ..Here, we describe a family of proteins in yeast (ARTs, for arrestin-related trafficking adaptors) that function by targeting specific PM proteins to the endocytic system...
  39. Munshi U, Peegel H, Menon K. Palmitoylation of the luteinizing hormone/human chorionic gonadotropin receptor regulates receptor interaction with the arrestin-mediated internalization pathway. Eur J Biochem. 2001;268:1631-9 pubmed
    ..Coexpression of wild-type (WT) or C621/622G mutant receptors with arrestin-2 increased receptor internalization in 293T cells...
  40. Yamamoto S, Sippel K, Berson E, Dryja T. Defects in the rhodopsin kinase gene in the Oguchi form of stationary night blindness. Nat Genet. 1997;15:175-8 pubmed
    ..Recently a defect in arrestin, a member of the rod phototransduction pathway, was found to cause this disease in some Japanese patients...
  41. Lieven C, Ribich J, Crowe M, Levin L. Redox proteomic identification of visual arrestin dimerization in photoreceptor degeneration after photic injury. Invest Ophthalmol Vis Sci. 2012;53:3990-8 pubmed publisher
    ..The redox proteomic screen identified homodimers of visual arrestin (Arr1; S antigen) after toxic levels of light injury...
  42. Alloway P, Howard L, Dolph P. The formation of stable rhodopsin-arrestin complexes induces apoptosis and photoreceptor cell degeneration. Neuron. 2000;28:129-38 pubmed
    ..We now demonstrate the existence of stable, persistent complexes between rhodopsin and its regulatory protein arrestin in several different retinal degeneration mutants...
  43. Nakagawa M, Orii H, Yoshida N, Jojima E, Horie T, Yoshida R, et al. Ascidian arrestin (Ci-arr), the origin of the visual and nonvisual arrestins of vertebrate. Eur J Biochem. 2002;269:5112-8 pubmed
    b>Arrestin is one of the key proteins for the termination of G protein signaling...
  44. Cheung R, Malik M, Ravyn V, Tomkowicz B, Ptasznik A, Collman R. An arrestin-dependent multi-kinase signaling complex mediates MIP-1beta/CCL4 signaling and chemotaxis of primary human macrophages. J Leukoc Biol. 2009;86:833-45 pubmed publisher
    ..We show further that arrestins were recruited into the complex, and arrestin down-regulation impaired complex formation and macrophage chemotaxis toward MIP-1beta...
  45. Shinoda J, Kikuchi Y. Rod1, an arrestin-related protein, is phosphorylated by Snf1-kinase in Saccharomyces cerevisiae. Biochem Biophys Res Commun. 2007;364:258-63 pubmed
    Metazoan arrestin proteins bind to seven-transmembrane proteins, mediate their internalization and play central roles in the subsequent signal transduction pathway. In Saccharomyces cerevisiae, there are several arrestin-related proteins...
  46. Vishnivetskiy S, Francis D, Van Eps N, Kim M, Hanson S, Klug C, et al. The role of arrestin alpha-helix I in receptor binding. J Mol Biol. 2010;395:42-54 pubmed publisher
    ..to both P-Rh* and light-activated unphosphorylated rhodopsin, these mutations reduce the stability of the arrestin complex with P-Rh*, but not with light-activated unphosphorylated rhodopsin...
  47. Poulin B, Butcher A, McWilliams P, Bourgognon J, Pawlak R, Kong K, et al. The M3-muscarinic receptor regulates learning and memory in a receptor phosphorylation/arrestin-dependent manner. Proc Natl Acad Sci U S A. 2010;107:9440-5 pubmed publisher
    ..G(q/11)-signaling but was uncoupled from phosphorylation-dependent processes such as receptor internalization and arrestin recruitment...
  48. Saga M, Mashima Y, Kudoh J, Oguchi Y, Shimizu N. Gene analysis and evaluation of the single founder effect in Japanese patients with Oguchi disease. Jpn J Ophthalmol. 2004;48:350-2 pubmed
    To analyze mutations of the arrestin/S-antigen (SAG) gene in nine newly identified Oguchi disease patients, and to examine whether the 926delA (formerly called 1147delA) mutation in the SAG gene is inherited from a single founder...
  49. Roman G, He J, Davis R. kurtz, a novel nonvisual arrestin, is an essential neural gene in Drosophila. Genetics. 2000;155:1281-95 pubmed
    The kurtz gene encodes a novel nonvisual arrestin. krz is located at the most-distal end of the chromosome 3R, the third gene in from the telomere. krz is expressed throughout development...
  50. Zhu X, Brown B, Li A, Mears A, Swaroop A, Craft C. GRK1-dependent phosphorylation of S and M opsins and their binding to cone arrestin during cone phototransduction in the mouse retina. J Neurosci. 2003;23:6152-60 pubmed
    ..receptor (GPCR) kinase 1 (GRK1) phosphorylation of light-activated rhodopsin (R*) followed by rod arrestin binding. Deactivation of the cone phototransduction cascade in the mammalian retina is delineated poorly...
  51. Nair K, Balasubramanian N, Slepak V. Signal-dependent translocation of transducin, RGS9-1-Gbeta5L complex, and arrestin to detergent-resistant membrane rafts in photoreceptors. Curr Biol. 2002;12:421-5 pubmed
    ..In contrast, the G protein transducin, the RGS9-1-Gbeta5L complex, and the p44 isoform of arrestin undergo dramatic translocation to the raft upon illumination...
  52. Teo M, Tan L, Lim L, Manser E. The tyrosine kinase ACK1 associates with clathrin-coated vesicles through a binding motif shared by arrestin and other adaptors. J Biol Chem. 2001;276:18392-8 pubmed
    ..A central region in ACK1 containing a conserved motif behaves as a clathrin adaptor and competes with beta-arrestin for a common binding site on the clathrin N-terminal head domain...
  53. Key T, Foutz T, Gurevich V, Sklar L, Prossnitz E. N-formyl peptide receptor phosphorylation domains differentially regulate arrestin and agonist affinity. J Biol Chem. 2003;278:4041-7 pubmed
    ..known about the relationships between the sites of receptor phosphorylation, the resulting affinities of arrestin binding, and the ensuing mechanisms of receptor regulation for any given GPCR...
  54. Nabhan J, Hu R, Oh R, Cohen S, Lu Q. Formation and release of arrestin domain-containing protein 1-mediated microvesicles (ARMMs) at plasma membrane by recruitment of TSG101 protein. Proc Natl Acad Sci U S A. 2012;109:4146-51 pubmed publisher
    ..budding is driven by a specific interaction of TSG101 with a tetrapeptide PSAP motif of an accessory protein, arrestin domain-containing protein 1 (ARRDC1), which we show is localized to the plasma membrane through its arrestin ..
  55. Benned Jensen T, Mokrosinski J, Rosenkilde M. The E92K melanocortin 1 receptor mutant induces cAMP production and arrestin recruitment but not ERK activity indicating biased constitutive signaling. PLoS ONE. 2011;6:e24644 pubmed publisher
    ..Furthermore, the mutation induced a constitutive recruitment of ?-arrestin. This phenomenon is only observed in MC1R, however, as the equivalent mutations in MC2-5R had no effect on ..
  56. Lan H, Liu Y, Bell M, Gurevich V, Neve K. A dopamine D2 receptor mutant capable of G protein-mediated signaling but deficient in arrestin binding. Mol Pharmacol. 2009;75:113-23 pubmed publisher
    ..The goals of this study were to compare arrestin-binding determinants in D(2) and D(3) receptors other than phosphorylation sites and to create a D(2) receptor ..
  57. Horie T, Orii H, Nakagawa M. Structure of ocellus photoreceptors in the ascidian Ciona intestinalis larva as revealed by an anti-arrestin antibody. J Neurobiol. 2005;65:241-50 pubmed
    ..of the ocellus photoreceptors in the larvae of the ascidian Ciona intestinalis was revealed by using an anti-arrestin (anti-Ci-Arr) antibody...
  58. Singh V, Aballay A. Endoplasmic reticulum stress pathway required for immune homeostasis is neurally controlled by arrestin-1. J Biol Chem. 2012;287:33191-7 pubmed
    ..To investigate further how GPCR signaling controls immune homeostasis at the organismal level, we studied arrestin-1 (ARR-1), which is the only GPCR adaptor protein in C. elegans...
  59. Palczewski K, Van Hooser J, Garwin G, Chen J, Liou G, Saari J. Kinetics of visual pigment regeneration in excised mouse eyes and in mice with a targeted disruption of the gene encoding interphotoreceptor retinoid-binding protein or arrestin. Biochemistry. 1999;38:12012-9 pubmed
    ..b>Arrestin forms a complex with activated rhodopsin, quenches its activity, and affects the release of all-trans-retinal in ..
  60. Vishnivetskiy S, Gimenez L, Francis D, Hanson S, Hubbell W, Klug C, et al. Few residues within an extensive binding interface drive receptor interaction and determine the specificity of arrestin proteins. J Biol Chem. 2011;286:24288-99 pubmed publisher
    ..Visual arrestin-1 preferentially binds rhodopsin, whereas the two non-visual arrestins interact with hundreds of G protein-..
  61. Palmitessa A, Benovic J. Arrestin and the multi-PDZ domain-containing protein MPZ-1 interact with phosphatase and tensin homolog (PTEN) and regulate Caenorhabditis elegans longevity. J Biol Chem. 2010;285:15187-200 pubmed publisher
    ..To further elucidate the role of arrestin in IGF-1R signaling, we employed an in vivo approach to investigate the role of ARR-1, the sole arrestin ortholog ..
  62. DeGraff J, Gurevich V, Benovic J. The third intracellular loop of alpha 2-adrenergic receptors determines subtype specificity of arrestin interaction. J Biol Chem. 2002;277:43247-52 pubmed
    Nonvisual arrestins (arrestin-2 and -3) serve as adaptors to link agonist-activated G protein-coupled receptors to the endocytic machinery...
  63. Doan T, Azevedo A, Hurley J, Rieke F. Arrestin competition influences the kinetics and variability of the single-photon responses of mammalian rod photoreceptors. J Neurosci. 2009;29:11867-79 pubmed publisher
    ..vary little from one to the next, requiring reproducible inactivation of rhodopsin by phosphorylation and arrestin binding...
  64. Krock B, Mills Henry I, Perkins B. Retrograde intraflagellar transport by cytoplasmic dynein-2 is required for outer segment extension in vertebrate photoreceptors but not arrestin translocation. Invest Ophthalmol Vis Sci. 2009;50:5463-71 pubmed publisher
    ..Morphant photoreceptor connecting cilia were swollen, but neither opsin nor arrestin was mislocalized, although IFT88 accumulated in the distal region of the connecting cilium...