desmoglein 1

Summary

Summary: A desmosomal cadherin that is an autoantigen in the acquired skin disorder PEMPHIGUS FOLIACEUS.

Top Publications

  1. Peifer M, McCrea P, Green K, Wieschaus E, Gumbiner B. The vertebrate adhesive junction proteins beta-catenin and plakoglobin and the Drosophila segment polarity gene armadillo form a multigene family with similar properties. J Cell Biol. 1992;118:681-91 pubmed
    ..The implications of these results for the structure and function of different cell-cell adhesive junctions are discussed. ..
  2. Ishii K, Harada R, Matsuo I, Shirakata Y, Hashimoto K, Amagai M. In vitro keratinocyte dissociation assay for evaluation of the pathogenicity of anti-desmoglein 3 IgG autoantibodies in pemphigus vulgaris. J Invest Dermatol. 2005;124:939-46 pubmed
    ..These findings indicate that this dissociation assay will provide a simple and objective biological method to measure the pathogenic strength of pemphigus autoantibodies. ..
  3. Hanakawa Y, Schechter N, Lin C, Nishifuji K, Amagai M, Stanley J. Enzymatic and molecular characteristics of the efficiency and specificity of exfoliative toxin cleavage of desmoglein 1. J Biol Chem. 2004;279:5268-77 pubmed
    ..epidermis by hydrolyzing a single peptide bond, Glu381-Gly382, located between extracellular domains 3 and 4 of desmoglein 1 (Dsg1). Enzyme activity is dependent on the calcium-stabilized structure of Dsg1...
  4. Descargues P, Deraison C, Prost C, Fraitag S, Mazereeuw Hautier J, D Alessio M, et al. Corneodesmosomal cadherins are preferential targets of stratum corneum trypsin- and chymotrypsin-like hyperactivity in Netherton syndrome. J Invest Dermatol. 2006;126:1622-32 pubmed
    ..We demonstrated that, in a majority of patients, desmoglein 1 (Dsg1) and desmocollin 1 (Dsc1) were dramatically reduced in the upper most living layers of the epidermis...
  5. Getsios S, Simpson C, Kojima S, Harmon R, Sheu L, Dusek R, et al. Desmoglein 1-dependent suppression of EGFR signaling promotes epidermal differentiation and morphogenesis. J Cell Biol. 2009;185:1243-58 pubmed publisher
    Dsg1 (desmoglein 1) is a member of the cadherin family of Ca(2+)-dependent cell adhesion molecules that is first expressed in the epidermis as keratinocytes transit out of the basal layer and becomes concentrated in the uppermost cell ..
  6. Belloni Fortina A, Faggion D, Pigozzi B, Peserico A, Bordignon M, Baldo V, et al. Detection of autoantibodies against recombinant desmoglein 1 and 3 molecules in patients with pemphigus vulgaris: correlation with disease extent at the time of diagnosis and during follow-up. Clin Dev Immunol. 2009;2009:187864 pubmed publisher
    The recent availability of cDNA clones for pemphigus antigens has allowed the production of recombinant desmoglein 1 and desmoglein 3 molecules and the development of an ELISA approach in order to determine levels of antibodies to them...
  7. Green K, Gaudry C. Are desmosomes more than tethers for intermediate filaments?. Nat Rev Mol Cell Biol. 2000;1:208-16 pubmed
    ..But desmosomes have also recently been recognized as sensors that respond to environmental and cellular cues by modulating their assembly state and, possibly, their signalling functions. ..
  8. Chan P, Ohyama B, Nishifuji K, Yoshida K, Ishii K, Hashimoto T, et al. Immune response towards the amino-terminus of desmoglein 1 prevails across different activity stages in nonendemic pemphigus foliaceus. Br J Dermatol. 2010;162:1242-50 pubmed publisher
    ..These findings are valuable for understanding the biology of Dsg-mediated cellular adhesion as well as for the development of epitope-based monitoring and therapeutic strategies. ..
  9. Inui S, Amagai M, Tsutsui S, Fukuhara Yoshida S, Itami S, Katayama I. Atypical pemphigus involving the esophagus with IgG antibodies to desmoglein 3 and IgA antibodies to desmoglein 1. J Am Acad Dermatol. 2006;55:354-5 pubmed

More Information

Publications62

  1. Payne A, Siegel D, Stanley J. Targeting pemphigus autoantibodies through their heavy-chain variable region genes. J Invest Dermatol. 2007;127:1681-91 pubmed
    ..Together, these data suggest novel V(H) gene-targeted approaches toward PV treatment. ..
  2. Amagai M, Tsunoda K, Suzuki H, Nishifuji K, Koyasu S, Nishikawa T. Use of autoantigen-knockout mice in developing an active autoimmune disease model for pemphigus. J Clin Invest. 2000;105:625-31 pubmed
    ..This model will be valuable for developing novel therapeutic strategies. Furthermore, our approach can be applied broadly for the development of various autoimmune disease models. ..
  3. Kallel Sellami M, Ben Ayed M, Mouquet H, Drouot L, Zitouni M, Mokni M, et al. Anti-desmoglein 1 antibodies in Tunisian healthy subjects: arguments for the role of environmental factors in the occurrence of Tunisian pemphigus foliaceus. Clin Exp Immunol. 2004;137:195-200 pubmed
    Pemphigus foliaceus is an autoimmune blistering skin disease mediated by autoantibodies directed against desmoglein 1 and occurs as a sporadic form throughout the world, or as an endemic form called fogo selvagem in Brazil...
  4. Yokouchi M, Saleh M, Kuroda K, Hachiya T, Stanley J, Amagai M, et al. Pathogenic epitopes of autoantibodies in pemphigus reside in the amino-terminal adhesive region of desmogleins which are unmasked by proteolytic processing of prosequence. J Invest Dermatol. 2009;129:2156-66 pubmed publisher
    ..These findings support the idea that at least some pathogenic pemphigus autoantibodies induce the loss of cell adhesion by directly binding the trans-interaction site of Dsgs. ..
  5. Abreu Velez A, Javier Patiño P, Montoya F, Bollag W. The tryptic cleavage product of the mature form of the bovine desmoglein 1 ectodomain is one of the antigen moieties immunoprecipitated by all sera from symptomatic patients affected by a new variant of endemic pemphigus. Eur J Dermatol. 2003;13:359-66 pubmed
    ..This study confirms the biological importance of the ectodomain of Dsg1 as well as the relevance of conformational epitopes in various types of pemphigus. ..
  6. Schleifer S, Versteeg S, van Oost B, Willemse T. Familial footpad hyperkeratosis and inheritance of keratin 2, keratin 9, and desmoglein 1 in two pedigrees of Irish Terriers. Am J Vet Res. 2003;64:715-20 pubmed
    To investigate the possibility that variants in the acidic or basic keratin genes or in desmoglein 1 may cause the clinical manifestation of familial footpad hyperkeratosis in Irish Terriers...
  7. Kozlowska A, Hashimoto T, Jarzabek Chorzelska M, Amagai A, Nagata Y, Strasz Z, et al. Pemphigus herpetiformis with IgA and IgG antibodies to desmoglein 1 and IgG antibodies to desmocollin 3. J Am Acad Dermatol. 2003;48:117-22 pubmed
    ..features of pemphigus herpetiformis associated with IgG and IgA anti-keratinocyte cell surface antibodies to desmoglein 1 (Dsg1) and exclusively IgG antibodies to desmocollin 3 (Dsc3)...
  8. Ayed M, Martel P, Zitouni M, Gilbert D, Turki H, Mokni M, et al. Tunisian endemic pemphigus foliaceus is associated with desmoglein 1 gene polymorphism. Genes Immun. 2002;3:378-9 pubmed
    b>Desmoglein 1 is the target antigen and probably the initiating immunogen of the autoantibody response in pemphigus foliaceus (PF), a blistering autoimmune skin disease...
  9. Hanakawa Y, Matsuyoshi N, Stanley J. Expression of desmoglein 1 compensates for genetic loss of desmoglein 3 in keratinocyte adhesion. J Invest Dermatol. 2002;119:27-31 pubmed
    ..These studies show that desmoglein-1 can compensate for loss of desmoglein-3-mediated adhesion, and provide genetic evidence confirming the desmoglein compensation hypothesis. ..
  10. Mahoney M, Simpson A, Aho S, Uitto J, Pulkkinen L. Interspecies conservation and differential expression of mouse desmoglein gene family. Exp Dermatol. 2002;11:115-25 pubmed
    ..In summary, while desmogleins share high homology at both the gene and protein level, their expression is spatially and temporally regulated, potentially contributing to their significant role in cell-cell adhesion during development. ..
  11. King I, Angst B, Hunt D, Kruger M, Arnemann J, Buxton R. Hierarchical expression of desmosomal cadherins during stratified epithelial morphogenesis in the mouse. Differentiation. 1997;62:83-96 pubmed
    ..Upregulation of DSG1 message was temporally linked to that of DSG3 in all tissues apart from the non-glandular gastric epithelium. ..
  12. Anzai H, Stanley J, Amagai M. Production of low titers of anti-desmoglein 1 IgG autoantibodies in some patients with staphylococcal scalded skin syndrome. J Invest Dermatol. 2006;126:2139-41 pubmed
  13. Schmidt E, Dähnrich C, Rosemann A, Probst C, Komorowski L, Saschenbrecker S, et al. Novel ELISA systems for antibodies to desmoglein 1 and 3: correlation of disease activity with serum autoantibody levels in individual pemphigus patients. Exp Dermatol. 2010;19:458-63 pubmed publisher
    ..In conclusion, the use of the ectodomains of Dsg 3 and 1 as target antigens expressed in a human cell line resulted in sensitive and specific ELISA systems for both diagnosis and monitoring of PV and PF. ..
  14. Wu H, Wang Z, Yan A, Lyle S, Fakharzadeh S, Wahl J, et al. Protection against pemphigus foliaceus by desmoglein 3 in neonates. N Engl J Med. 2000;343:31-5 pubmed
  15. Harman K, Gratian M, Seed P, Bhogal B, Challacombe S, Black M. Diagnosis of pemphigus by ELISA: a critical evaluation of two ELISAs for the detection of antibodies to the major pemphigus antigens, desmoglein 1 and 3. Clin Exp Dermatol. 2000;25:236-40 pubmed
    ..The Dsg 1 and Dsg 3 ELISAs also provided objective, quantitative, reproducible data which allowed differentiation of PV from PF and in view of these advantages, they are likely to become a routine technique in diagnostic laboratories. ..
  16. Sharma V, Prasad H, Khandpur S, Kumar A. Evaluation of desmoglein enzyme-linked immunosorbent assay (ELISA) in Indian patients with pemphigus vulgaris. Int J Dermatol. 2006;45:518-22 pubmed
    To evaluate the role of the enzyme-linked immunosorbent assay (ELISA) test for the detection of antibodies to desmoglein 1 (dsg1) and desmoglein 3 (dsg3) in the diagnosis of pemphigus vulgaris (PV), and its correlation with disease ..
  17. Mouquet H, Farci S, Joly P, Maillere B, Leblond J, Drouot L, et al. A truncated alternative spliced isoform of human desmoglein 1 contains a specific T cell epitope binding to the pemphigus foliaceus-associated HLA class II DRbeta1*0102 molecule. J Immunol. 2006;177:6517-26 pubmed
    ..These data provide an illustration of an autoantigen encoded by alternative spliced transcript that may participate in the pathogenesis of the disease by bearing PF-associated HLA class II restricted-epitope. ..
  18. Diaz L, Prisayanh P, Dasher D, Li N, Evangelista F, Aoki V, et al. The IgM anti-desmoglein 1 response distinguishes Brazilian pemphigus foliaceus (fogo selvagem) from other forms of pemphigus. J Invest Dermatol. 2008;128:667-75 pubmed
    Fogo selvagem (FS) and pemphigus foliaceus (PF) possess pathogenic IgG anti-desmoglein 1-(Dsg1) autoantibodies. Although PF occurs sporadically, FS is endemic in Limao Verde (LV), Brazil (3.4% prevalence)...
  19. Pigozzi B, Peserico A, Schiesari L, Alaibac M. Pemphigus foliaceus evolving into pemphigus vulgaris: a probable example of 'intermolecular epitope spreading' confirmed by enzyme-linked immunosorbent assay study. J Eur Acad Dermatol Venereol. 2008;22:242-4 pubmed publisher
  20. Waschke J, Spindler V, Bruggeman P, Zillikens D, Schmidt G, Drenckhahn D. Inhibition of Rho A activity causes pemphigus skin blistering. J Cell Biol. 2006;175:721-7 pubmed
    ..hallmarks of pemphigus pathogenesis such as epidermal blistering in human skin, cell dissociation, and loss of desmoglein 1 (Dsg 1)-mediated binding probed by laser tweezers...
  21. Petzl Erler M, Malheiros D. Pemphigus foliaceus and desmoglein 1 gene polymorphism: is there any relationship?. J Autoimmun. 2005;25:121-5 pubmed
    ..Autoantibodies to desmoglein 1 (dsg1) are a hallmark of pemphigus foliaceus (PF), a disease characterized by skin blistering resulting from ..
  22. Wong M, Cheang M, Yorida E, Coldman A, Gilks C, Huntsman D, et al. Loss of desmoglein 1 expression associated with worse prognosis in head and neck squamous cell carcinoma patients. Pathology. 2008;40:611-6 pubmed publisher
    ..Seventy-eight cases of head and neck squamous cell carcinoma were immunohistochemically stained for desmoglein 1, desmoglein 2, desmoglein 3, p53, bcl-2, vimentin, cyclin D1, p16, p21, p27, E-cadherin, and E2F-1 in paraffin-..
  23. Jamora M, Jiao D, Bystryn J. Antibodies to desmoglein 1 and 3, and the clinical phenotype of pemphigus vulgaris. J Am Acad Dermatol. 2003;48:976-7 pubmed
  24. Descargues P, Deraison C, Bonnart C, Kreft M, Kishibe M, Ishida Yamamoto A, et al. Spink5-deficient mice mimic Netherton syndrome through degradation of desmoglein 1 by epidermal protease hyperactivity. Nat Genet. 2005;37:56-65 pubmed
    ..LEKTI deficiency causes abnormal desmosome cleavage in the upper granular layer through degradation of desmoglein 1 due to stratum corneum tryptic enzyme and stratum corneum chymotryptic enzyme-like hyperactivity...
  25. Getsios S, Amargo E, Dusek R, Ishii K, Sheu L, Godsel L, et al. Coordinated expression of desmoglein 1 and desmocollin 1 regulates intercellular adhesion. Differentiation. 2004;72:419-33 pubmed
    b>Desmoglein 1 (Dsg1) is a component of desmosomes present in the upper epidermis and can be targeted by autoimmune antibodies or bacterial toxins, resulting in skin blistering diseases...
  26. Abida O, Zitouni M, Kallel Sellami M, Mahfoudh N, Kammoun A, Ben Ayed M, et al. Tunisian endemic pemphigus foliaceus is associated with the HLA-DR3 gene: anti-desmoglein 1 antibody-positive healthy subjects bear protective alleles. Br J Dermatol. 2009;161:522-7 pubmed publisher
    ..In the northern group, only the DRB1*04 and DQB1*0301 alleles were found to be associated. Interestingly, anti-desmoglein 1 antibody-positive healthy controls did not carry susceptibility alleles but, in contrast, most carried ..
  27. Warren S, Arteaga L, Rivitti E, Aoki V, Hans Filho G, Qaqish B, et al. The role of subclass switching in the pathogenesis of endemic pemphigus foliaceus. J Invest Dermatol. 2003;120:104-8 pubmed
    ..Acquisition of an IgG4 response is a key step in the development of clinical disease. ..
  28. Li G, Schaider H, Satyamoorthy K, Hanakawa Y, Hashimoto K, Herlyn M. Downregulation of E-cadherin and Desmoglein 1 by autocrine hepatocyte growth factor during melanoma development. Oncogene. 2001;20:8125-35 pubmed
    ..Melanocytes and two melanoma lines, WM164 and WM35, expressed normal level E-cadherin and Desmoglein 1, whereas most melanomas (18 out of 20) expressed no E-cadherin and significantly reduced Desmoglein 1...
  29. Smith E, Fuchs E. Defining the interactions between intermediate filaments and desmosomes. J Cell Biol. 1998;141:1229-41 pubmed
    ..In similar overlay assays, PP1 binds to DP and Dsc1a, and to a lesser extent, desmoglein 1 (Dsg1), while PG binds to Dsg1 and more weakly to Dsc1a and DP...
  30. Kowalczyk A, Bornslaeger E, Borgwardt J, Palka H, Dhaliwal A, Corcoran C, et al. The amino-terminal domain of desmoplakin binds to plakoglobin and clusters desmosomal cadherin-plakoglobin complexes. J Cell Biol. 1997;139:773-84 pubmed
    ..These results identify a role for desmoplakin in organizing the desmosomal cadherin-plakoglobin complex and provide new insights into the hierarchy of protein interactions that occur in the desmosomal plaque. ..
  31. Lundstrom A, Serre G, Haftek M, Egelrud T. Evidence for a role of corneodesmosin, a protein which may serve to modify desmosomes during cornification, in stratum corneum cell cohesion and desquamation. Arch Dermatol Res. 1994;286:369-75 pubmed
    ..Results from analyses of nonpalmoplantar stratum corneum suggested that corneodesmosin is degraded in this tissue in a way that may be similar to that in plantar stratum corneum.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  32. Nilles L, Parry D, Powers E, Angst B, Wagner R, Green K. Structural analysis and expression of human desmoglein: a cadherin-like component of the desmosome. J Cell Sci. 1991;99 ( Pt 4):809-21 pubmed
    ..2, 4.0 and 3.0 kb. Each of these cross-hybridizing mRNAs is coordinately expressed in normal human keratinocytes in response to long-term culture and increased calcium. ..
  33. Naoe Y, Hata T, Tanigawa K, Kimura H, Masunaga T. Bidimensional analysis of desmoglein 1 distribution on the outermost corneocytes provides the structural and functional information of the stratum corneum. J Dermatol Sci. 2010;57:192-8 pubmed publisher
    ..To investigate the distribution of desmoglein 1 (Dsg1), which may be a main component of corneodesmosomes (CDSs) in the SC, we used a bidimensional observation ..
  34. Nakashima H, Fujimoto M, Watanabe R, Ishiura N, Yamamoto A, Hashimoto T, et al. Herpetiform pemphigus without anti-desmoglein 1/3 autoantibodies. J Dermatol. 2010;37:264-8 pubmed publisher
    ..This case suggests that non-desmoglein antigen on keratinocyte cell surface can be targeted in some patients with this unusual variant of pemphigus. ..
  35. Maruyama H, Kawachi Y, Fujisawa Y, Itoh S, Furuta J, Ishii Y, et al. IgA/IgG pemphigus positive for anti-desmoglein 1 autoantibody. Eur J Dermatol. 2007;17:94-5 pubmed
  36. Roh J, Stanley J. Plakoglobin binding by human Dsg3 (pemphigus vulgaris antigen) in keratinocytes requires the cadherin-like intracytoplasmic segment. J Invest Dermatol. 1995;104:720-4 pubmed
    ..These results underscore the importance of a region, highly conserved in all desmogleins, in the carboxy terminus of the IC-cadherin-like subdomain for the localization of plakoglobin to desmosomes. ..
  37. Lin M, Fu C, Aoki V, Hans Filho G, Rivitti E, Moraes J, et al. Desmoglein-1-specific T lymphocytes from patients with endemic pemphigus foliaceus (fogo selvagem). J Clin Invest. 2000;105:207-13 pubmed
    ..These Dsg1-reactive FS T cells exhibited a CD4-positive memory T-cell phenotype and produced a T helper 2-like cytokine profile. These findings represent the initial steps in defining the role of T cells in FS autoimmunity. ..
  38. Cozzani E, Dal Bello M, Mastrogiacomo A, Drosera M, Parodi A. Antidesmoplakin antibodies in pemphigus vulgaris. Br J Dermatol. 2006;154:624-8 pubmed
    ..It remains a sensitive and specific substrate for the detection of anti-DP antibodies, which, in patients with pemphigus vulgaris, are probably caused by an epitope-spreading phenomenon. ..
  39. Donetti E, Bedoni M, Boschini E, Dellavia C, Barajon I, Gagliano N. Desmocollin 1 and desmoglein 1 expression in human epidermis and keratinizing oral mucosa: a comparative immunohistochemical and molecular study. Arch Dermatol Res. 2005;297:31-8 pubmed
    ..Up to now, the expression of the "skin type" desmosomal cadherins, i.e. desmocollin 1 (Dsc1) and desmoglein 1 (Dsg1), was correlated with the morphological features of keratinocyte terminal differentiation in epidermis, ..
  40. Sami N, Bhol K, Ahmed R. Influence of intravenous immunoglobulin therapy on autoantibody titers to desmoglein 3 and desmoglein 1 in pemphigus vulgaris. Eur J Dermatol. 2003;13:377-81 pubmed
    ..A sustained serological remission is observed in patients treated with i.v.Ig therapy. . ..
  41. Hanakawa Y, Selwood T, Woo D, Lin C, Schechter N, Stanley J. Calcium-dependent conformation of desmoglein 1 is required for its cleavage by exfoliative toxin. J Invest Dermatol. 2003;121:383-9 pubmed
    ..of exfoliative toxin, which hydrolyzes only one peptide bond in a highly structured calcium-binding domain of desmoglein 1, resulting in loss of its function. We investigated the basis of this exquisite specificity...
  42. Borgono C, Michael I, Komatsu N, Jayakumar A, Kapadia R, Clayman G, et al. A potential role for multiple tissue kallikrein serine proteases in epidermal desquamation. J Biol Chem. 2007;282:3640-52 pubmed
    ..leukocyte protease inhibitor, and elafin and 2) their ability to digest the (corneo)desmosomal cadherin, desmoglein 1. KLK1 was not inhibited by any SPI tested...
  43. Karpati S, Amagai M, Liu W, Dmochowski M, Hashimoto T, Horvath A. Identification of desmoglein 1 as autoantigen in a patient with intraepidermal neutrophilic IgA dermatosis type of IgA pemphigus. Exp Dermatol. 2000;9:224-8 pubmed
    ..This is the first case of IgA pemphigus where Dsg1 has been identified as the autoantigen. ..
  44. Hanakawa Y, Amagai M, Shirakata Y, Yahata Y, Tokumaru S, Yamasaki K, et al. Differential effects of desmoglein 1 and desmoglein 3 on desmosome formation. J Invest Dermatol. 2002;119:1231-6 pubmed
    ..We constructed recombinant adenoviruses containing desmoglein 1 and desmoglein 3 derivatives partly lacking the extracellular domain (desmoglein 1DeltaEC and desmoglein ..
  45. Amagai M, Stanley J. Desmoglein as a target in skin disease and beyond. J Invest Dermatol. 2012;132:776-84 pubmed publisher
    ..of staphylococcal scalded skin syndrome or bullous impetigo and pemphigus foliaceus led us to identify desmoglein 1 as the proteolytic target of staphylococcal exfoliative toxins...
  46. Marcozzi C, Burdett I, Buxton R, Magee A. Coexpression of both types of desmosomal cadherin and plakoglobin confers strong intercellular adhesion. J Cell Sci. 1998;111 ( Pt 4):495-509 pubmed
    ..We find that L cells expressing either one or both of the desmosomal cadherins desmocollin 2a or desmoglein 1 display weak cell-cell adhesion activity that is Ca2+-dependent...
  47. Arteaga L, Prisayanh P, Warren S, Liu Z, Diaz L, Lin M. A subset of pemphigus foliaceus patients exhibits pathogenic autoantibodies against both desmoglein-1 and desmoglein-3. J Invest Dermatol. 2002;118:806-11 pubmed
    ..These results suggest that a subset of patients with pemphigus foliaceus and fogo selvagem have antibodies to desmoglein-3 that may be involved in the pathogenesis of their cutaneous disease. ..
  48. Yamagami J, Kacir S, Ishii K, Payne A, Siegel D, Stanley J. Antibodies to the desmoglein 1 precursor proprotein but not to the mature cell surface protein cloned from individuals without pemphigus. J Immunol. 2009;183:5615-21 pubmed publisher
    In pemphigus foliaceus (PF), autoantibodies against desmoglein 1 (Dsg1) cause blisters. Using Ab phage display, we have cloned mAbs from a PF patient...
  49. Hallaji Z, Mortazavi H, Lajevardi V, Tamizifar B, Amirzargar A, Daneshpazhooh M, et al. Serum and salivary desmoglein 1 and 3 enzyme-linked immunosorbent assay in pemphigus vulgaris: correlation with phenotype and severity. J Eur Acad Dermatol Venereol. 2010;24:275-80 pubmed publisher
    ..07). Salivary Dsg3 antibodies were not correlated with mucosal severity (P=0.16). Saliva Dsg ELISA could be used for diagnosis of PV. Salivary Dsg1 antibodies had a significant correlation with mucosal severity. ..
  50. Ishii K, Lin C, Siegel D, Stanley J. Isolation of pathogenic monoclonal anti-desmoglein 1 human antibodies by phage display of pemphigus foliaceus autoantibodies. J Invest Dermatol. 2008;128:939-48 pubmed
    Pemphigus foliaceus (PF) is a blistering disease caused by autoantibodies to desmoglein 1 (Dsg1) that cause loss of epidermal cell adhesion...
  51. Hachem J, Wagberg F, Schmuth M, Crumrine D, Lissens W, Jayakumar A, et al. Serine protease activity and residual LEKTI expression determine phenotype in Netherton syndrome. J Invest Dermatol. 2006;126:1609-21 pubmed
    ..These studies provide a mechanistic basis for phenotypic variations in NS, and describe compensatory mechanisms that permit survival of NS patients in the face of unrelenting SP attack. ..
  52. Waschke J, Menendez Castro C, Bruggeman P, Koob R, Amagai M, Gruber H, et al. Imaging and force spectroscopy on desmoglein 1 using atomic force microscopy reveal multivalent Ca(2+)-dependent, low-affinity trans-interaction. J Membr Biol. 2007;216:83-92 pubmed
    b>Desmoglein 1 is a desmosomal member of the cadherin family expressed in stratified epithelia. Desmoglein 1 is the target adhesion molecule of severe blistering skin diseases such as pemphigus or bullous impetigo...
  53. Cirillo N, Gombos F, Lanza A. Changes in desmoglein 1 expression and subcellular localization in cultured keratinocytes subjected to anti-desmoglein 1 pemphigus autoimmunity. J Cell Physiol. 2007;210:411-6 pubmed
    The complexity of pemphigus acantholysis together with the weak expression of desmoglein 1 (Dsg1) in cultured keratinocytes have made the study on the pathogenic action of anti-Dsg1 antibodies quite difficult...