Summary: The study of significant causes and processes in the development of mental illness.

Top Publications

  1. Magee J, Harden K, Teachman B. Psychopathology and thought suppression: a quantitative review. Clin Psychol Rev. 2012;32:189-201 pubmed publisher
    Recent theories of psychopathology have suggested that thought suppression intensifies the persistence of intrusive thoughts, and proposed that difficulty with thought suppression may differ between groups with and without ..
  2. McLaughlin K, Gadermann A, Hwang I, Sampson N, Al Hamzawi A, Andrade L, et al. Parent psychopathology and offspring mental disorders: results from the WHO World Mental Health Surveys. Br J Psychiatry. 2012;200:290-9 pubmed publisher
    ..0-19.9%) than other (7.1-14.0%) disorders. Parent psychopathology is a robust non-specific predictor associated with a substantial proportion of offspring disorders.
  3. Sinn N, Milte C, Howe P. Oiling the brain: a review of randomized controlled trials of omega-3 fatty acids in psychopathology across the lifespan. Nutrients. 2010;2:128-70 pubmed publisher
    ..This review provides an updated overview of the published and the registered clinical trials that investigate effects of n-3 PUFA supplementation on mental health and behavior, highlighting methodological differences and issues. ..
  4. Colonnelli M, Cross J, Davies S, D Argenzio L, Scott R, Pickles A, et al. Psychopathology in children before and after surgery for extratemporal lobe epilepsy. Dev Med Child Neurol. 2012;54:521-6 pubmed publisher
    ..b>Psychopathology is common in children with extratemporal epilepsy...
  5. Taş C, Brown E, Cubukçuoğlu Z, Aydemir O, Danaci A, Brune M. Towards an integrative approach to understanding quality of life in schizophrenia: the role of neurocognition, social cognition, and psychopathology. Compr Psychiatry. 2013;54:262-8 pubmed publisher
    ..In conclusion, social cognitive skills appear to play a crucial role in the experience of one's own subjective well-being, which could help to explain previous inconsistencies in the literature investigating QoL in schizophrenia. ..
  6. Costello E, Copeland W, Angold A. Trends in psychopathology across the adolescent years: what changes when children become adolescents, and when adolescents become adults?. J Child Psychol Psychiatry. 2011;52:1015-25 pubmed publisher
    ..Other phobias and disruptive behavior disorders also fall. Further study of changes in rates of disorder across developmental stages could inform etiological research and guide interventions. ..
  7. Brietzke E, Kauer Sant Anna M, Jackowski A, Grassi Oliveira R, Bucker J, Zugman A, et al. Impact of childhood stress on psychopathology. Braz J Psychiatr. 2012;34:480-8 pubmed
    ..with a particular focus on childhood trauma, brain morphology, cognitive functions, and the development of psychopathology and MD...
  8. Thompson R, Parker K, Hallmayer J, Waugh C, Gotlib I. Oxytocin receptor gene polymorphism (rs2254298) interacts with familial risk for psychopathology to predict symptoms of depression and anxiety in adolescent girls. Psychoneuroendocrinology. 2011;36:144-7 pubmed publisher
    ..These findings highlight the potential importance of this OXTR gene polymorphism in the etiology of depression and anxiety disorders. ..
  9. McEwan K, Gilbert P, Duarte J. An exploration of competitiveness and caring in relation to psychopathology. Br J Clin Psychol. 2012;51:19-36 pubmed publisher

Scientific Experts

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  1. Ekinci O, Topcuoglu V, Sabuncuoglu O, Berkem M, Akin E, Gumustas F. The association of tattooing/body piercing and psychopathology in adolescents: a community based study from Istanbul. Community Ment Health J. 2012;48:798-803 pubmed publisher
    We aimed to investigate the association of psychopathology with tattooing and body piercing among adolescents in Istanbul by means of self-report questionnaires...
  2. Kranick S, Ekanayake V, Martinez V, Ameli R, Hallett M, Voon V. Psychopathology and psychogenic movement disorders. Mov Disord. 2011;26:1844-50 pubmed publisher
    ..A careful psychological assessment is indicated to optimize therapeutic modalities. ..
  3. Miller G, Rockstroh B. Endophenotypes in psychopathology research: where do we stand?. Annu Rev Clin Psychol. 2013;9:177-213 pubmed publisher
    Endophenotypes for psychopathology have been conceived as latent, unobserved, but measureable manifestations of phenomena that causally connect genetic liability to clinical disorder...
  4. Balazs J, Miklósi M, Keresztény A, Hoven C, Carli V, Wasserman C, et al. Adolescent subthreshold-depression and anxiety: psychopathology, functional impairment and increased suicide risk. J Child Psychol Psychiatry. 2013;54:670-7 pubmed publisher
    ..Analyses of Covariance were conducted on SDQ scores to explore psychopathology of the defined groups...
  5. Kluge M, Schussler P, Dresler M, Schmidt D, Yassouridis A, Uhr M, et al. Effects of ghrelin on psychopathology, sleep and secretion of cortisol and growth hormone in patients with major depression. J Psychiatr Res. 2011;45:421-6 pubmed publisher
    ..We therefore studied the impact of ghrelin on psychopathology, sleep and secretion of cortisol and GH in patients with major depression...
  6. Fairchild G. The developmental psychopathology of motivation in adolescence. Dev Cogn Neurosci. 2011;1:414-29 pubmed publisher
    Adolescence is a key period for the emergence of psychopathology, with many psychiatric disorders having their modal age-of-onset during this period...
  7. Whittle S, Dennison M, Vijayakumar N, Simmons J, Yucel M, Lubman D, et al. Childhood maltreatment and psychopathology affect brain development during adolescence. J Am Acad Child Adolesc Psychiatry. 2013;52:940-952.e1 pubmed publisher
    ..However, it is not known if and when these effects emerge during adolescence and whether comorbid psychopathology is more likely to explain these effects...
  8. Boskovic M, Vovk T, Saje M, Goričar K, Dolzan V, Kores Plesnicar B, et al. Association of SOD2, GPX1, CAT, and TNF genetic polymorphisms with oxidative stress, neurochemistry, psychopathology, and extrapyramidal symptoms in schizophrenia. Neurochem Res. 2013;38:433-42 pubmed publisher
    ..TNF-308G>A by assessing their association with biomarkers of oxidative stress, neurochemistry, psychopathology of schizophrenia and extrapyramidal symptoms in Caucasian schizophrenia patients treated with haloperidol ..
  9. Schepis T, Hakes J. Non-medical prescription use increases the risk for the onset and recurrence of psychopathology: results from the National Epidemiological Survey on Alcohol and Related Conditions. Addiction. 2011;106:2146-55 pubmed publisher
    ..of the non-medical use of prescription medications (NUPM) and strong cross-sectional associations between psychopathology and NUPM, we examined whether a history of NUPM increased the risk for onset and recurrence of ..
  10. Achenbach T, Rescorla L, Ivanova M. International epidemiology of child and adolescent psychopathology I: diagnoses, dimensions, and conceptual issues. J Am Acad Child Adolesc Psychiatry. 2012;51:1261-72 pubmed publisher
    ..However, the findings disclose challenges to be met to help clinicians take account of the similarities and differences found for psychopathology in different societies.
  11. Karatzias T, Chouliara Z, Power K, Collin P, Yellowlees A, Grierson D. General psychopathology in anorexia nervosa: the role of psychosocial factors. Clin Psychol Psychother. 2010;17:519-27 pubmed publisher
    The aim of the present study was to investigate psychosocial correlates of comorbid psychopathology. Data were collected from a total of 90 female inpatients with anorexia nervosa (AN)...
  12. Lipszyc J, Schachar R. Inhibitory control and psychopathology: a meta-analysis of studies using the stop signal task. J Int Neuropsychol Soc. 2010;16:1064-76 pubmed publisher
    ..This confirms an inhibition deficit in ADHD, and suggests that comorbid ADHD has different effects on inhibition in patients with ANX, ODD/CD, and RD. Further studies are needed to firmly establish an inhibition deficit in OCD and SCZ. ..
  13. Vaidyanathan U, Nelson L, Patrick C. Clarifying domains of internalizing psychopathology using neurophysiology. Psychol Med. 2012;42:447-59 pubmed publisher
    ..distinct patterns of association for both the startle blink reflex and the ERN with three key domains of psychopathology: (1) Fear (or phobic) disorders (distinguished by increased startle to unpleasant stimuli, but normal-range ..
  14. Carson S. Creativity and psychopathology: a shared vulnerability model. Can J Psychiatry. 2011;56:144-53 pubmed
    ..However, highly creative people have demonstrated elevated risk for certain forms of psychopathology, including mood disorders, schizophrenia spectrum disorders, and alcoholism...
  15. Hirshfeld Becker D, Micco J, Henin A, Petty C, Faraone S, Mazursky H, et al. Psychopathology in adolescent offspring of parents with panic disorder, major depression, or both: a 10-year follow-up. Am J Psychiatry. 2012;169:1175-84 pubmed
    ..These results support the need to screen and monitor the offspring of adults presenting for treatment of panic disorder or major depressive disorder. ..
  16. Sperry D, Widom C. Child abuse and neglect, social support, and psychopathology in adulthood: a prospective investigation. Child Abuse Negl. 2013;37:415-25 pubmed publisher
    ..Efforts to better understand the timing and mechanisms involved in these relationships are needed to guide preventive interventions and treatment. ..
  17. Nolen Hoeksema S. Emotion regulation and psychopathology: the role of gender. Annu Rev Clin Psychol. 2012;8:161-87 pubmed publisher
    This review addresses three questions regarding the relationships among gender, emotion regulation, and psychopathology: (a) are there gender differences in emotion regulation strategies, (b) are emotion regulation strategies similarly ..
  18. Thompson A, Nelson B, Bruxner A, O CONNOR K, Mossaheb N, Simmons M, et al. Does specific psychopathology predict development of psychosis in ultra high-risk (UHR) patients?. Aust N Z J Psychiatry. 2013;47:380-90 pubmed publisher
    ..Clinicians should be cautious about the use of clinical profile alone in such individuals when determining who is at highest risk. ..
  19. Glover V. Annual Research Review: Prenatal stress and the origins of psychopathology: an evolutionary perspective. J Child Psychol Psychiatry. 2011;52:356-67 pubmed publisher
    ..the role of genetics, there is good evidence that prenatal stress exposure can increase the risk for later psychopathology. Why should this be? In our evolutionary history it is possible that some increase in these characteristics ..
  20. Menon V. Large-scale brain networks and psychopathology: a unifying triple network model. Trends Cogn Sci. 2011;15:483-506 pubmed publisher
    ..recent conceptual and methodological developments which are contributing to a paradigm shift in the study of psychopathology. I summarize methods for characterizing aberrant brain networks and demonstrate how network analysis provides ..
  21. Micali N, Simonoff E, Elberling H, Rask C, Olsen E, Skovgaard A. Eating patterns in a population-based sample of children aged 5 to 7 years: association with psychopathology and parentally perceived impairment. J Dev Behav Pediatr. 2011;32:572-80 pubmed publisher
    There is still a lack of research on childhood eating patterns and their correlates in relation to psychopathology and parentally perceived impact in general population samples...
  22. Byrne M, Deane F. Enhancing patient adherence: outcomes of medication alliance training on therapeutic alliance, insight, adherence, and psychopathology with mental health patients. Int J Ment Health Nurs. 2011;20:284-95 pubmed publisher
    ..and attitudes, in relation to enhancing patient adherence and patient changes in adherence, insight, and psychopathology were collected at baseline and at 6 and 12 months...
  23. Muzik M, Bocknek E, Broderick A, Richardson P, Rosenblum K, Thelen K, et al. Mother-infant bonding impairment across the first 6 months postpartum: the primacy of psychopathology in women with childhood abuse and neglect histories. Arch Womens Ment Health. 2013;16:29-38 pubmed publisher the context of maternal risk, including maternal history of childhood abuse and neglect and postpartum psychopathology, and to test the association between self-reported bonding impairment and observed positive parenting ..
  24. Schmidt N, Van Hulle C, Brooker R, Meyer L, Lemery Chalfant K, Goldsmith H. Wisconsin Twin Research: early development, childhood psychopathology, autism, and sensory over-responsivity. Twin Res Hum Genet. 2013;16:376-84 pubmed publisher
    ..Across the various studies, testing occasions occurred between 3 months and 18 years of age. Data collection for some aspects of the research program has concluded and, for other aspects, longitudinal follow-ups are in progress. ..
  25. Markon K, Chmielewski M, Miller C. The reliability and validity of discrete and continuous measures of psychopathology: a quantitative review. Psychol Bull. 2011;137:856-79 pubmed publisher
    ..e., dimensional) and discrete (i.e., categorical) measures of psychopathology. Overall, results suggest an expected 15% increase in reliability and 37% increase in validity through ..
  26. Fekete T, Beacher F, Cha J, Rubin D, Mujica Parodi L. Small-world network properties in prefrontal cortex correlate with predictors of psychopathology risk in young children: a NIRS study. Neuroimage. 2014;85 Pt 1:345-53 pubmed publisher
    ..We set out to explore whether NIRS could be utilized in assessing the risk of developmental psychopathology in young children...
  27. Theunissen S, Rieffe C, Netten A, Briaire J, Soede W, Schoones J, et al. Psychopathology and its risk and protective factors in hearing-impaired children and adolescents: a systematic review. JAMA Pediatr. 2014;168:170-7 pubmed publisher
    Pediatric hearing impairment is a chronic handicap that can potentially lead to the development of psychopathology. Yet, for hearing-impaired children and adolescents, the exact occurrence of various forms of psychopathology and its ..
  28. Gardiner E, Iarocci G. Unhappy (and happy) in their own way: a developmental psychopathology perspective on quality of life for families living with developmental disability with and without autism. Res Dev Disabil. 2012;33:2177-92 pubmed publisher
    ..A central tenet of developmental psychopathology is that the study of adaptive and maladaptive development is mutually informative...
  29. Borsboom D, Cramer A. Network analysis: an integrative approach to the structure of psychopathology. Annu Rev Clin Psychol. 2013;9:91-121 pubmed publisher
    In network approaches to psychopathology, disorders result from the causal interplay between symptoms (e.g., worry ? insomnia ? fatigue), possibly involving feedback loops (e.g...
  30. Achenbach T. Multicultural evidence-based assessment of child and adolescent psychopathology. Transcult Psychiatry. 2010;47:707-26 pubmed publisher
    ..As reported in over 7000 publications from 85 societies and cultural groups, evidence-based assessment provides a common data language for clinicians, trainees, and researchers around the world. ..
  31. Diler R, Birmaher B, Axelson D, Obreja M, Monk K, Hickey M, et al. Dimensional psychopathology in offspring of parents with bipolar disorder. Bipolar Disord. 2011;13:670-8 pubmed publisher
    To compare the dimensional psychopathology in offspring of parents with bipolar disorder (BP) with offspring of community control parents as assessed by the Child Behavior Checklist (CBCL)...
  32. McLaughlin K, Hatzenbuehler M, Mennin D, Nolen Hoeksema S. Emotion dysregulation and adolescent psychopathology: a prospective study. Behav Res Ther. 2011;49:544-54 pubmed publisher
    Emotion regulation deficits have been consistently linked to psychopathology in cross-sectional studies. However, the direction of the relationship between emotion regulation and psychopathology is unclear...
  33. Bernier R, Mao A, Yen J. Psychopathology, families, and culture: autism. Child Adolesc Psychiatr Clin N Am. 2010;19:855-67 pubmed publisher
    ..In this article, cultural influences on the prevalence of autism and the diagnostic and treatment processes are reviewed and synthesized through a consideration of the developmental context and through clinical practice suggestions. ..
  34. Arango C, Bobes J, Kirkpatrick B, Garcia Garcia M, Rejas J. Psychopathology, coronary heart disease and metabolic syndrome in schizophrenia spectrum patients with deficit versus non-deficit schizophrenia: findings from the CLAMORS study. Eur Neuropsychopharmacol. 2011;21:867-75 pubmed publisher
    ..8% (95% CI: 8.8-15.5) vs. 6.0% (95% CI: 4.4-8.1), (p<0.05)]. Schizophrenia spectrum patients with DS were more obese and had a higher CHD risk than non-deficit patients. ..
  35. Binbay T, Drukker M, Elbi H, Tanık F, Ozkinay F, Onay H, et al. Testing the psychosis continuum: differential impact of genetic and nongenetic risk factors and comorbid psychopathology across the entire spectrum of psychosis. Schizophr Bull. 2012;38:992-1002 pubmed publisher
    ..Liability associated with respectively affective and nonaffective symptom domains, in interaction with environmental risks, may operate by impacting differentially over a quasi-continuous extended psychosis phenotype in the population. ..
  36. Wu L, Woody G, Yang C, Blazer D. How do prescription opioid users differ from users of heroin or other drugs in psychopathology: results from the National Epidemiologic Survey on Alcohol and Related Conditions. J Addict Med. 2011;5:28-35 pubmed publisher
    ..Findings suggest the need to distinguish between these four groups in research and treatment as they may have different natural histories and treatment needs. ..
  37. Schmid B, Blomeyer D, Buchmann A, Trautmann Villalba P, Zimmermann U, Schmidt M, et al. Quality of early mother-child interaction associated with depressive psychopathology in the offspring: a prospective study from infancy to adulthood. J Psychiatr Res. 2011;45:1387-94 pubmed publisher
    ..impact of maternal responsiveness and stimulation during early mother-child interaction on depressive psychopathology was examined until adulthood...
  38. Slopen N, Williams D, Seedat S, Moomal H, Herman A, Stein D. Adversities in childhood and adult psychopathology in the South Africa Stress and Health Study: associations with first-onset DSM-IV disorders. Soc Sci Med. 2010;71:1847-54 pubmed publisher
  39. De Los Reyes A. Strategic objectives for improving understanding of informant discrepancies in developmental psychopathology research. Dev Psychopathol. 2013;25:669-82 pubmed publisher
    Developmental psychopathology researchers and practitioners commonly conduct behavioral assessments using multiple informants' reports (e.g., parents, teachers, practitioners, children, and laboratory observers)...
  40. Haslam N, Holland E, Kuppens P. Categories versus dimensions in personality and psychopathology: a quantitative review of taxometric research. Psychol Med. 2012;42:903-20 pubmed publisher
    ..This review indicates that most latent variables of interest to psychiatrists and personality and clinical psychologists are dimensional, and that many influential taxonic findings of early taxometric research are likely to be spurious. ..
  41. Borsboom D, Cramer A, Schmittmann V, Epskamp S, Waldorp L. The small world of psychopathology. PLoS ONE. 2011;6:e27407 pubmed publisher
    ..This explains the limited successes of genetic, neuroscientific, and etiological approaches to unravel their causes. We outline a psychosystems approach to investigate the structure and dynamics of mental disorders. ..
  42. Tiemensma J, Biermasz N, Middelkoop H, van der Mast R, Romijn J, Pereira A. Increased prevalence of psychopathology and maladaptive personality traits after long-term cure of Cushing's disease. J Clin Endocrinol Metab. 2010;95:E129-41 pubmed publisher
    b>Psychopathology and maladaptive personality traits are often observed during the active phase of Cushing's disease (CD)...
  43. Cutajar M, Mullen P, Ogloff J, Thomas S, Wells D, Spataro J. Psychopathology in a large cohort of sexually abused children followed up to 43 years. Child Abuse Negl. 2010;34:813-22 pubmed publisher to severe abuse involving penetration or multiple offenders were associated with greater risk for psychopathology. This study confirms that child sexual abuse is a substantial risk factor for a range of mental disorders in ..
  44. Hill S, Tessner K, McDermott M. Psychopathology in offspring from families of alcohol dependent female probands: a prospective study. J Psychiatr Res. 2011;45:285-94 pubmed publisher
    ..Multiplex familial risk for alcohol dependence is a significant predictor of substance use disorders by young adulthood. Familial risk and an earlier childhood disorder may set the stage for later development of SUD. ..
  45. Sanislow C, Pine D, Quinn K, Kozak M, Garvey M, Heinssen R, et al. Developing constructs for psychopathology research: research domain criteria. J Abnorm Psychol. 2010;119:631-9 pubmed publisher
    ..exists a divide between findings from integrative neuroscience and clinical research focused on mechanisms of psychopathology. Specifically, a clear correspondence does not emerge between clusters of complex clinical symptoms and ..
  46. Glover V, Hill J. Sex differences in the programming effects of prenatal stress on psychopathology and stress responses: an evolutionary perspective. Physiol Behav. 2012;106:736-40 pubmed publisher
    ..have been few studies so far in humans which differentiate effects of prenatal stress on male and female psychopathology. Some studies support the animal models, but the evidence is inconsistent...
  47. Roefs A, Huijding J, Smulders F, MacLeod C, de Jong P, Wiers R, et al. Implicit measures of association in psychopathology research. Psychol Bull. 2011;137:149-93 pubmed publisher
    ..Text Revision; American Psychiatric Association, 2000) Axis I psychopathology are organized into three categories: (a) studies comparing groups having a disorder with controls, (b) ..
  48. Reininghaus U, McCabe R, Burns T, Croudace T, Priebe S. The validity of subjective quality of life measures in psychotic patients with severe psychopathology and cognitive deficits: an item response model analysis. Qual Life Res. 2012;21:237-46 pubmed publisher
    ..Patients with more severe general psychopathology were less likely to rate their 'personal safety' positively (OR .96, 95% CI .93-.99)...
  49. Hyde L, Bogdan R, Hariri A. Understanding risk for psychopathology through imaging gene-environment interactions. Trends Cogn Sci. 2011;15:417-27 pubmed publisher
    Examining the interplay of genes, experience and the brain is crucial to understanding psychopathology. We review the recent gene-environment interaction (G×E) and imaging genetics literature with the goal of developing models to bridge ..
  50. Bouso J, González D, Fondevila S, Cutchet M, Fernandez X, Ribeiro Barbosa P, et al. Personality, psychopathology, life attitudes and neuropsychological performance among ritual users of Ayahuasca: a longitudinal study. PLoS ONE. 2012;7:e42421 pubmed publisher
    ..ayahuasca use on general psychological well-being, mental health and cognition, here we assessed personality, psychopathology, life attitudes and neuropsychological performance in regular ayahuasca users (n = 127) and controls (n = 115)..
  51. McGoron L, Gleason M, Smyke A, Drury S, Nelson C, Gregas M, et al. Recovering from early deprivation: attachment mediates effects of caregiving on psychopathology. J Am Acad Child Adolesc Psychiatry. 2012;51:683-93 pubmed publisher
    Children exposed to early institutional rearing are at risk for developing psychopathology. The present investigation examines caregiving quality and the role of attachment security as they relate to symptoms of psychopathology in young ..
  52. Daskalakis N, Oitzl M, Schachinger H, Champagne D, de Kloet E. Testing the cumulative stress and mismatch hypotheses of psychopathology in a rat model of early-life adversity. Physiol Behav. 2012;106:707-21 pubmed publisher
    In the present study, we tested both the cumulative stress and the mismatch hypothesis of psychopathology. For this purpose the combined effects of early-life adversity and later-life stress exposure on behavioral markers of psychosis ..
  53. Cuthbert B, Kozak M. Constructing constructs for psychopathology: the NIMH research domain criteria. J Abnorm Psychol. 2013;122:928-37 pubmed publisher
    ..Finally, this commentary considers the Bilder group's article, explicating the ways in which multilevel models can foster development of hypotheses and informatics approaches needed for further RDoC progress. ..