family

..The major focus is on the Transforming Growth Factor beta family, with lesser focus on the Wnt and Hedgehog pathways of secreted signaling molecules...

..Dlk is a member of the EGF-like homeotic gene family which influences cell fate during development...

..is tightly associated with membranes, especially the Golgi complex, while the other class is composed of a super family of soluble or cytosolic enzymes (designated SULT)...

..Cdk5, a member of a large family of proline-directed serine/threonine protein kinases, was originally cloned by homology to other members of the ..

..and recruitment of probands from both clinical and community settings and enrollment and evaluation of the relatives; (3) selection and implementation of core features and endophenotypes for mood disorders and migraine; and (4) ..

During FY2006, we continued our exploration of the biology and evolution of the RNase A family of ribonucleases, an unusual enzyme family that is restricted to vertebrate species...

..of transmissible components of a condition by comparing the rates and risk factors for diseases in relatives of cases with those of controls...

..Thus, the SOX family of transcription factors appears to use Ca+2/calmodulin both as import receptor and molecular switch allowing for ..

..families are ascertained through case or control probands, and survival and covariate data are obtained on relatives. The approach we developed allows estimation of the effects of covariates on the age of onset and on the ..

The Child and Family Research Section (CFRS) in the Laboratory of Comparative Ethology in the National Institute of Child Health and Human Development investigates dispositional, experiential, and environmental factors that contribute to ..

..This exchange reaction is regulated by a family of stress-responsive protein kinases that specifically phosphorylate the alpha subunit of eIF2 on serine at ..

..American and Latino parents to discuss issues of sex with their children and to examine the influence of the family and culture on sexual risk behaviors among African American and Latino youth...

..American and Latino parents to discuss issues of sex with their children and to examine the influence of the family and culture on sexual risk behaviors among African American and Latino youth...

..detailed protocols and extensive sets of controls for the experimental manipulation of the activity of Rho GTPase family members by RNA interference using siRNA...

..Among them, the AP-1 family of transcription factors, including c-Fos and c-Jun family members, plays a key role...

..type of sugar addition to proteins known as mucin-type O-linked glycosylation, which is initiated by the enzyme family known as the polypeptide GalNAc transferases (ppGaNTases or pgants)...

The dynamin family of proteins consists of unique GTPases involved in membrane fission and fusion events throughout the cell...

..ACTIVE HUMAN L1 HAS REDUCED THE GENETIC FITNESS OF HUMANS ?We earlier showed that the human-specific L1Hs family (also called L1Pa1, or Ta) evolved from the ancestral L1Pa2 family soon after the human / chimpanzee divergence, ..

..In this fiscal year, family data have been collected in Louisiana. Data collection is expected to continue for several more years. Dr...

..showed that the Hsp104 chaperone is necessary for [URE3] prion propagation, and that overexpression of the Hsp40-family chaperone Ydj1p can cure the [URE3] prion...

The problem of alcoholism in American Indians has been comprehensively addressed in three family linkage datasets: 1] SW tribe; 2] Eastern Oklahoma tribe with low prevalence of alcoholism; 3] Plains Indian tribe with neuropsychological ..

..We previously found that relatives of leukemia cases were more likely to have leukemia and other cancers, especially breast cancr in a sibling than ..

DESCRIPTION (provided by applicant): In this revised PPG, we propose to analyze the function of a new family of genes that we have recently discovered called TIM (T cell Immunoglobulin and Mucin domain containing molecules), which was ..

..recently found that one of the sites necessary for PRE activity, Site 2, can be bound by members of the Sp1/KLF family of zinc-finger proteins...

..3) to identify genetic effects underlying quantitative traits using statistical genetic analysis in collaborative family studies; and 4) to continue the development and dissemination of the Genometric Analysis Simulation Package (G.A.S...

..and across the multiple stakeholder levels affecting children's health care across the world- patient and family, communities, health care organizations, and the broad political and cultural environment 4) Mobilize efforts to ..

..to this discovery was the early, pre-clinical detection and characterization of BCML in unaffected first-degree relatives in familial CLL. This has been accomplished using less sophisticated 2 or 3-color analysis...

..A large portion of our work is focused on studies of the Tec family of tyrosine kinases...

..Little is known, however, about other family-based factors that may be related to parental acceptance and psychological functioning among LGB youth...

..e., family/parents, group/peer) are incorporated in the treatment program...

DESCRIPTION (provided by applicant): Young adult women ages 18-29 years attending family planning clinics report higher rates of intimate partner violence and sexual assault (IPV/SA) as compared to their same-age peers; however, standard-..

..These data indicate that a specific form of family therapy is effective in the treatment of adolescents with anorexia nervosa...

..Our team has recently identified novel regulatory molecules of inflammation in the CATERPILLER family, specifically cryopyrin (which upregulates neutrophilic inflammation and monocytic function) and monarch-1, (which ..

..different proteins and have called them the SIBLING (Small Integrin-Binding LIgand, N-linked Glycoprotein) family. The genes encoding these proteins are all clustered in a tandem fashion within a short stretch of human ..

..benefit from risk-reducing surgery; but the effects of screening unselected women for HBOC risk using USPSTF family history criteria are unknown as widespread familial risk assessment has not been feasible...

..Bcl-2 family proteins are principal regulators of mitochondrial oxidative stress and intrinsic apoptosis...

..benefit from risk-reducing surgery; but the effects of screening unselected women for HBOC risk using USPSTF family history criteria are unknown as widespread familial risk assessment has not been feasible...

..Many of these adolescents have multiple family members with diabetes or obesity that can act as positive, but also negative role models...

..An additional focus is on the characterization of proteins expressed by a unique family of genes (PE family) found only in mycobacteria...

..of perinatally HIV-infected children and their adult caregivers in Argentina by developing and testing a family-based and community-linked intervention meant to promote health and mental health and prevent risk behavior as ..

..The objectives of the PA are fulfilled by focusing on medical adherence, family functioning, and tailored interventions...

..proposed study is to examine the impact of the HOPE (HIV prevention Outreach for Parents and Early adolescents) Family Program, a family-based HIV and drug abuse prevention program for early adolescent youth and their adult ..

..In this proposal, we seek to determine whether the newly described serine/threonine protein kinase D (PKD) family kinases are involved in the pathogenesis and progression of IPF...

..profile that will be predictive of subsequent AD by virtue of being similar to the AD gene expression profile of family members with the same mutation and with AD...

DESCRIPTION (provided by applicant): Caring for an elderly family member with dementia is burdensome and stressful to the majority of caregivers, and contributes to psychiatric morbidity in the form of higher prevalence and incidence of ..

..objectives of this pilot study are to: 1) test the feasibility of conducting a longitudinal study of 40 patient/family caregiver dyads experiencing advanced cancer or AIDS given the vulnerability of this population; 2) obtain ..

..or activity-related opportunities they provide, but also through their parenting strategies and aspects of the family/home environment. The goals of this project are two-fold...

..proposed study is to examine the impact of the HOPE (HIV prevention Outreach for Parents and Early adolescents) Family Program, a family-based HIV and drug abuse prevention program for early adolescent youth and their adult ..

..China's elder care has long depended upon acute care and family support, but with China's rapid economic development, the traditional multi-generational family has declined...

..In the absence of porins, substrate specific channels belonging to the OprD family are responsible for uptake of the majority of low molecular weight compounds in P. aeruginosa...

..These proteins complexes have been dubbed, "inflammasomes." This renewal application focuses on NLR-family member NLRP1 (NALP1) as a prototype of the NLR family...

Successful management of diabetes in youth is heavily dependent upon family adaptation to the affective, behavioral, and cognitive demands imposed by the disease...

Work has progressed in family-based statistical methods for studying genetic effects on qualitative and quantitative traits...

..ecological model of child development, which posits that investments should be defined broadly, including not only family income, but such additional inputs as parental time, emotional warmth and nurturance, monitoring of activities, ..

DESCRIPTION (provided by applicant): The Family - Native American Cancer Education for Survivors (NACES) project is a collaborative effort among Native American Cancer Initiatives, Inc...

..GenSalt is a unique NHLBI-sponsored family feeding study conducted in 3,153 participants from 658 families living in rural areas of northern China...

..caregiver roles and then, to identify what keeps them committed to providing for the long-term care needs of relatives or strangers...

The aim of this study was to measure the burden of care for family caregivers of AIDS patients. A cross-sectional exploratory design was used to describe the care experiences of family caregivers of AIDS care recipients...

The purpose of this study was to explore changes in family health associated with child's chronic illness and hospitalization...

..of the difficult issues which obstruct the development of meaningful partnerships among nurses, family and their relatives is facilitated...

AIMS AND OBJECTIVES: This study set out to explore, from the family's point of view, ways in which nursing staff can promote family health during the child's hospital stay...

..BACKGROUND: Earlier research learned that hope is crucial for relatives of traumatic coma patients...

The descriptive, exploratory study consisted of 30 adult family members who completed a 2-part instrument: the Demographics Data Questionnaire and the Needs Met Inventory. Data were analyzed using descriptive and inferential statistics...

..BACKGROUND: Stroke has a high incidence in China. Most stroke survivors are accompanied by family caregivers during hospitalisation...

..from a study, which sought to better understand the experience of nursing home placement from the viewpoint of relatives. The focus here is on the self-perceived contribution of family carers to life within the home...

Support from health professionals can assist family caregivers and have a positive impact on their health...

..Moreover, in certain circumstances, patient confidentiality may need to be breached if the life of the ill family member or others is in danger...

..To learn about the family's experience of managing chemotherapy-induced neutropenia (CIN), a grounded-theory methodology was used to analyze ..

..The implications for health care providers include: an awareness of changed family roles and relationship attachments that can cause strain on family systems; familiarity with the complex demands ..

OBJECTIVE: This qualitative study explored the kinds of worry that family caregivers experience when their older relatives are hospitalized...

..Stroke alters the lives of both patients and their relatives. Few studies have explored first time affected relatives' experiences of suddenly becoming a relative to a ..

..Participants were asked about their needs in managing the care of their family member and the factors that facilitated and/or hindered the transition to the home and influenced them in ..

..aspect of beginning treatment for pediatric AML--the "behind the scenes" experience of the home and family connection...

..Through e-mail communication, 11 participants were asked to respond to 5 questions about experiences with parents, family, friends, school, and healthcare providers, as well as provide demographic information...

..Nurses can use these findings to improve the care and long-term outcomes of children diagnosed with ADHD...

..Study participants included 10 family groups who had a child with a chronic illness and 12 practitioners from the disciplines of nursing, medicine, ..

..Conflicts with professional carers should be avoided. Every attempt should be made to develop models of long-term support and care that alleviate sources of burden on relatives. Further research is necessary to develop such models.

..The study found that being informed rapidly, meeting other parents and receiving support from the extended family are all needs experienced by parents that help identify appropriate nursing interventions.

The purpose of this study was to examine the relationship between spiritual well-being and caregiver burden in family caregivers of persons with Alzheimer's disease...

Limited research has been undertaken regarding family caregivers' burden and quality of life (QOL) when providing care for a family member with schizophrenia in the People's Republic of China...

PURPOSE: To describe the experiences and demands of families who care for their mentally ill relatives at home in Botswana. DESIGN: Grounded theory design with triangulated data sources...

Qualitative nursing research into the experience of family members caring for a dying loved one has been limited. This study used a phenomenological approach to explore this experience...

..The aim of this study was to measure the burden associated with caring for a family member who had been critically ill...

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Research has consistently shown that family caregivers have a variety of unmet needs, despite comprehensive professional support for caregivers being a central aim of palliative care...

....

..the presence of a greater power, (b) practicing rituals, (c) being one with nature, and (d) interacting with family and friends...

..The findings of this study are important for cancer nursing practice as health professionals need to acknowledge the role of carers in the chemotherapy day hospital setting and facilitate their involvement in care...

..Stressors that emerged in 2000 included being alone, tests, family fighting, too many things to do, and boyfriend/girlfriend issues...

..support and the two subscales among three time points, whereas there was significant difference between intra-family and extra-family support at each time point...

AIM: To describe and understand the experiences of Chinese family members of terminally ill patients during the end of life process in a palliative care unit...

BACKGROUND: The role of family is central to the wellbeing and health of individuals. Family attitudes, habits and routines affect the way individuals promote their health...

..and descriptive study we investigated the experiences of and impact on young girls and older women caring for family members living with HIV/AIDS and other chronic and terminal illnesses at home in three districts of Botswana...

..Increased awareness and understanding of these meanings are important for nurses as they provide health care for this increasing population...

This exploratory study investigates relatives' overall experiences of the critical care environment and how staff perceived these experiences...

..Interpretive analysis revealed four patterns in learning the baby as meaningful constellations of family and social worlds. The implications of the findings for strengthening nursing care for these families are described...

..The self-reported health of female caregivers indicates poor health. Lower caregiver health is associated with lower income, rented accommodation, little support, and stigmatization of the caregiver by relatives.

..Twelve family members were interviewed with the focus on their needs of support by MHP, then the interviews were analyzed ..

OBJECTIVE: Relatives of patients undergoing cardiac surgery expect successful outcome but sometimes complications cause death...

Previous research in a retrospective community-based study suggested that some relatives had difficulty coping with their bereavement when the pre-bereavement period had not been managed well...

..study with Heideggerian hermeneutic contextual analysis was used to illuminate the perceived needs of family members who were in the critical care waiting room...

..SAMPLE: The sample included five bereaved family members who had lost a loved one to a sudden death and who were all members of a bereavement support group held in ..

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..facility in Western Australia that was selected on the basis of its reputation of being highly sought after by relatives requiring formal care for older family members and also having a high level of ongoing involvement of relatives...

..Little research is available on family caregivers' experiences after placing their loved ones in a nursing home...

..Six categories were developed about issues in psychological care. Implications for practice included the important role of the family, need for improved communication and improved staff awareness of issues.

..Unpaid caregivers spend a substantial percentage of each week "helping out," often with older relatives, which requires major changes in their work patterns...

Two focus group interviews with 15 relatives, investigated family caregivers' perceptions of having a relative in a dementia care unit. Data analysis revealed the significant theme of living with loss...

Researchers have studied negative effects of caregiving on a family caregiver; however, less is known about positive aspects of exchanging assistance for both members of a family caregiving dyad...

..for a relative with schizophrenia and to test its associations with their demographic characteristics, social and family factors and health condition...

In Ireland, there is a dearth of research exploring the perceived health and social care needs and experiences of family caregivers of older people...

..perceived social support and level of depression of caregivers during the transition phase immediately following a family members' discharge from the hospital to the community; (b) to determine the association between determinants and ..

..The results of the study challenge health care professionals to commit themselves to family-centered work, in which knowing the family's history and current life situation is key to providing high-quality ..