thirst

Summary

Summary: A drive stemming from a physiological need for WATER.

Top Publications

  1. De Luca L, Vendramini R, Pereira D, Colombari D, David R, de Paula P, et al. Water deprivation and the double- depletion hypothesis: common neural mechanisms underlie thirst and salt appetite. Braz J Med Biol Res. 2007;40:707-12 pubmed
    Water deprivation-induced thirst is explained by the double-depletion hypothesis, which predicts that dehydration of the two major body fluid compartments, the extracellular and intracellular compartments, activates signals that combine ..
  2. Johnson A. The sensory psychobiology of thirst and salt appetite. Med Sci Sports Exerc. 2007;39:1388-400 pubmed
    b>Thirst and the hunger for sodium containing fluids and food (i.e., sodium appetite) are the consequences of the generation of unique central nervous system states...
  3. McKiernan F, Houchins J, Mattes R. Relationships between human thirst, hunger, drinking, and feeding. Physiol Behav. 2008;94:700-8 pubmed publisher
    There is a widely held view that hunger prompts feeding to ensure energy needs are met, while thirst cues drinking to address hydration requirements...
  4. McKinley M, Johnson A. The physiological regulation of thirst and fluid intake. News Physiol Sci. 2004;19:1-6 pubmed
    b>Thirst is important for maintaining body fluid homeostasis and may arise from deficits in either intracellular or extracellular fluid volume...
  5. McKiernan F, Hollis J, McCabe G, Mattes R. Thirst-drinking, hunger-eating; tight coupling?. J Am Diet Assoc. 2009;109:486-90 pubmed publisher
    Although thirst and hunger have historically motivated drinking and feeding, respectively, the high and increasing consumption of energy-yielding beverages and energy-diluted foods may have degraded the predictive value of these ..
  6. Kenefick R, Hazzard M, Mahood N, Castellani J. Thirst sensations and AVP responses at rest and during exercise-cold exposure. Med Sci Sports Exerc. 2004;36:1528-34 pubmed
    The purpose of this study was to 1) determine the effect of hypohydration (HYPO) on thirst sensations during moderate exercise in the cold and 2) determine a possible mechanism for a cold-induced decline in thirst...
  7. Kong J, Zhang Z, Li D, Wong K, Zhang Y, Szeto F, et al. Loss of vitamin D receptor produces polyuria by increasing thirst. J Am Soc Nephrol. 2008;19:2396-405 pubmed publisher
  8. D anci K, Vibhakar A, Kanter J, Mahoney C, Taylor H. Voluntary dehydration and cognitive performance in trained college athletes. Percept Mot Skills. 2009;109:251-69 pubmed
    ..Dehydration was associated with higher thirst and negative mood ratings as well as better Digit Span performance...
  9. Wright M, Woodrow G, O Brien S, King N, Dye L, Blundell J, et al. Polydipsia: a feature of peritoneal dialysis. Nephrol Dial Transplant. 2004;19:1581-6 pubmed
    ..These patients sometimes blame excessive thirst. There has been little work in this area and no work documenting polydipsia among peritoneal dialysis (PD) ..

More Information

Publications62

  1. Edmonds C, Jeffes B. Does having a drink help you think? 6-7-Year-old children show improvements in cognitive performance from baseline to test after having a drink of water. Appetite. 2009;53:469-72 pubmed publisher
    ..interactions between time of test and water group (water/no water), with improvements in the water group on thirst and happiness ratings, visual attention and visual search, but not visual memory or visuomotor performance...
  2. Almiron Roig E, Drewnowski A. Hunger, thirst, and energy intakes following consumption of caloric beverages. Physiol Behav. 2003;79:767-73 pubmed
    Whereas soft drinks are described as primarily thirst-quenching liquids, juices and milk are said to be liquid foods, with a greater satiating power...
  3. Taylor A, McCarthy J, Stocker S. Mice lacking the transient receptor vanilloid potential 1 channel display normal thirst responses and central Fos activation to hypernatremia. Am J Physiol Regul Integr Comp Physiol. 2008;294:R1285-93 pubmed publisher
    Neurons of the organum vasculosum of the lamina terminalis (OVLT) are necessary for thirst and vasopressin secretion during hypersmolality in rodents...
  4. Stricker E, Sved A. Controls of vasopressin secretion and thirst: similarities and dissimilarities in signals. Physiol Behav. 2002;77:731-6 pubmed
    RATS HAVE TWO PROMINENT RESPONSES TO DEHYDRATION: secretion of the antidiuretic hormone, vasopressin (VP), and thirst. Many signals directly affect both responses...
  5. Meinders A, Meinders A. [How much water do we really need to drink?]. Ned Tijdschr Geneeskd. 2010;154:A1757 pubmed
    ..is strictly regulated via osmoregulation by the hormone vasopressin and the kidneys, in combination with the thirst mechanism and drinking. Fluid intake comes from food, metabolism and beverages, including water...
  6. Yamada H, LOUIE K, Glimcher P. Controlled water intake: a method for objectively evaluating thirst and hydration state in monkeys by the measurement of blood osmolality. J Neurosci Methods. 2010;191:83-9 pubmed publisher
    ..Further, the physical state associated with a subject monkey's thirst has not yet been objectively assessed under these conditions...
  7. Szinnai G, Schachinger H, Arnaud M, Linder L, Keller U. Effect of water deprivation on cognitive-motor performance in healthy men and women. Am J Physiol Regul Integr Comp Physiol. 2005;289:R275-80 pubmed
    ..Increased subjective task-related effort suggests that healthy volunteers exhibit cognitive compensating mechanisms for increased tiredness and reduced alertness during slowly progressive moderate dehydration. ..
  8. Stachenfeld N. Acute effects of sodium ingestion on thirst and cardiovascular function. Curr Sports Med Rep. 2008;7:S7-13 pubmed publisher
    ..volume and osmolality of body fluids, a number of integrated neural and hormonal systems have evolved to control thirst and sodium appetite...
  9. Stricker E, Hoffmann M. Presystemic signals in the control of thirst, salt appetite, and vasopressin secretion. Physiol Behav. 2007;91:404-12 pubmed
    ..These early signals clearly affect vasopressin (VP) secretion and thirst. They relate either to the distension of the stomach and proximal small intestine (presumably mediated by local ..
  10. Noakes T. Hydration in the marathon : using thirst to gauge safe fluid replacement. Sports Med. 2007;37:463-6 pubmed
    ..from developing mild to moderate fluid deficits caused by sweat losses during the hunt, a serum osmolality based thirst mechanism and the ability to 'outrun their thirst' (to resist the deleterious psychological and other effects of ..
  11. McKinley M, Cairns M, Denton D, Egan G, Mathai M, Uschakov A, et al. Physiological and pathophysiological influences on thirst. Physiol Behav. 2004;81:795-803 pubmed
    b>Thirst motivates animals to seek fluid and drink it. It is regulated by the central nervous system and arises from neural and chemical signals from the periphery interacting in the brain to stimulate a drive to drink...
  12. Schroeder N, Gallaher D, Arndt E, Marquart L. Influence of whole grain barley, whole grain wheat, and refined rice-based foods on short-term satiety and energy intake. Appetite. 2009;53:363-9 pubmed publisher
    ..Hunger, fullness, desire to eat, amount of food consumed, and thirst were assessed using a modified Visual Analog Scale (VAS) before and after the breakfast, snack and lunch...
  13. Smith D, Moore K, Tormey W, Baylis P, Thompson C. Downward resetting of the osmotic threshold for thirst in patients with SIADH. Am J Physiol Endocrinol Metab. 2004;287:E1019-23 pubmed
    ..normal amounts of fluid, despite plasma osmolalities well below the physiological osmotic threshold for onset of thirst. The regulation of thirst has not been previously studied in SIADH...
  14. Maresh C, Gabaree Boulant C, Armstrong L, Judelson D, Hoffman J, Castellani J, et al. Effect of hydration status on thirst, drinking, and related hormonal responses during low-intensity exercise in the heat. J Appl Physiol (1985). 2004;97:39-44 pubmed
    ..This condition, known as voluntary dehydration, is largely based on perceived thirst. To examine the role of preexercise dehydration on thirst and drinking during exercise-heat stress, 10 healthy men ..
  15. Hamad A, Khosrovaneh A, Gupta S, Fazal S, Manis T, Feinfeld D. Lack of effect of long-term use of angiotensin-converting enzyme inhibitors by hemodialysis patients on thirst and fluid weight gain. Ren Fail. 2002;24:461-6 pubmed
    ..Angiotensin-converting enzyme inhibitor (ACEI) has been shown to decrease thirst and interdialytic weight gain in 2-4 weeks of usage...
  16. Ainslie P, Campbell I, Frayn K, Humphreys S, MacLaren D, Reilly T, et al. Energy balance, metabolism, hydration, and performance during strenuous hill walking: the effect of age. J Appl Physiol (1985). 2002;93:714-23 pubmed
    ..Despite the dehydration and impaired performance in the older group, blood glucose concentrations were well maintained in both groups, probably mediated via the increased mobilization of fat. ..
  17. Martens M, Westerterp Plantenga M. Mode of consumption plays a role in alleviating hunger and thirst. Obesity (Silver Spring). 2012;20:517-24 pubmed publisher
    While studying the effect of structure on satiety, effects of mode of consumption, additional water to drink, and thirst have been neglected...
  18. Rodriguez G, Cordina S, Vazquez G, Suri M, Kirmani J, Ezzeddine M, et al. The hydration influence on the risk of stroke (THIRST) study. Neurocrit Care. 2009;10:187-94 pubmed publisher
    There is a decreased sensation of thirst and often dehydration among the elderly population. It is unclear whether it represents a contributing factor for cerebral ischemic events...
  19. Dion T, Savoie F, Asselin A, Gariepy C, Goulet E. Half-marathon running performance is not improved by a rate of fluid intake above that dictated by thirst sensation in trained distance runners. Eur J Appl Physiol. 2013;113:3011-20 pubmed publisher
    ..No study has tested the impact of EID upon running TT performance. We compared the effects of thirst-driven (TD) vs...
  20. Mattes R. Hunger and thirst: issues in measurement and prediction of eating and drinking. Physiol Behav. 2010;100:22-32 pubmed publisher
    Associations between hunger and eating and between thirst and drinking are generally weak...
  21. Hollis J, McKinley M, D Souza M, Kampe J, Oldfield B. The trajectory of sensory pathways from the lamina terminalis to the insular and cingulate cortex: a neuroanatomical framework for the generation of thirst. Am J Physiol Regul Integr Comp Physiol. 2008;294:R1390-401 pubmed publisher
    The pathways involved in the emotional aspects of thirst, the arousal and affect associated with the generation of thirst and the motivation to obtain satiation, have been studied but remain poorly understood...
  22. Sharif Naeini R, Ciura S, Zhang Z, Bourque C. Contribution of TRPV channels to osmosensory transduction, thirst, and vasopressin release. Kidney Int. 2008;73:811-5 pubmed publisher
    ..The behaviors (that is, thirst and sodium appetite) and renal responses (diuresis and natriuresis) that are modulated to mediate osmoregulatory ..
  23. Yamada H, Tymula A, LOUIE K, Glimcher P. Thirst-dependent risk preferences in monkeys identify a primitive form of wealth. Proc Natl Acad Sci U S A. 2013;110:15788-93 pubmed publisher
  24. Smith C, Curtis K, Smith J, Stricker E. Presystemic influences on thirst, salt appetite, and vasopressin secretion in the hypovolemic rat. Am J Physiol Regul Integr Comp Physiol. 2007;292:R2089-99 pubmed
    The present studies investigated the influence of presystemic signals on the control of thirst, salt appetite, and vasopressin (VP) secretion in rats during nonhypotensive hypovolemia...
  25. Samson W, White M, Price C, Ferguson A. Obestatin acts in brain to inhibit thirst. Am J Physiol Regul Integr Comp Physiol. 2007;292:R637-43 pubmed
    ..We conclude that obestatin does not act in pituitary gland to regulate GH secretion but may act in brain to alter thirst mechanisms...
  26. Egan G, Silk T, Zamarripa F, Williams J, Federico P, Cunnington R, et al. Neural correlates of the emergence of consciousness of thirst. Proc Natl Acad Sci U S A. 2003;100:15241-6 pubmed
    b>Thirst was induced by rapid i.v. infusion of hypertonic saline (0.51 M at 13.4 ml/min). Ten humans were neuroimaged by positron-emission tomography (PET) and four by functional MRI (fMRI)...
  27. McKinley M, Denton D, Oldfield B, De Oliveira L, Mathai M. Water intake and the neural correlates of the consciousness of thirst. Semin Nephrol. 2006;26:249-57 pubmed
    b>Thirst and resultant water drinking can arise in response to deficits in both the intracellular and extracellular fluid compartments. Inhibitory influences mediating the satiation of thirst also are necessary to prevent overhydration...
  28. Mistiaen P. Thirst, interdialytic weight gain, and thirst-interventions in hemodialysis patients: a literature review. Nephrol Nurs J. 2001;28:601-4, 610-3; quiz 614-5 pubmed
    A literature search completed over the period of 1980-1999 identified studies on the prevalence of thirst in hemodialysis (HD) patients and the relationship between thirst and interdialytic weight gain, as well as intervention studies in ..
  29. de Araujo I, Kringelbach M, Rolls E, McGlone F. Human cortical responses to water in the mouth, and the effects of thirst. J Neurophysiol. 2003;90:1865-76 pubmed
    ..The activity of the rostral anterior cingulate cortex thus appears to reflect the thirst level or motivational state of the subjects.
  30. Smith D, Finucane F, Phillips J, Baylis P, Finucane J, Tormey W, et al. Abnormal regulation of thirst and vasopressin secretion following surgery for craniopharyngioma. Clin Endocrinol (Oxf). 2004;61:273-9 pubmed
    ..the frequency of postoperative diabetes insipidus and the incidence and characteristics of abnormalities of thirst in a cohort of patients with craniopharyngioma, in whom neurosurgery had been performed...
  31. Scholey A, Sünram Lea S, Greer J, Elliott J, Kennedy D. Glucose enhancement of memory depends on initial thirst. Appetite. 2009;53:426-9 pubmed publisher
    ..Participants rated their mood, hunger and thirst, then consumed a 25 g glucose drink or a matched placebo 20 min prior to a verbal memory task...
  32. Shirreffs S, Merson S, Fraser S, Archer D. The effects of fluid restriction on hydration status and subjective feelings in man. Br J Nutr. 2004;91:951-8 pubmed
    ..Plasma volume decreased linearly throughout the FR trial amounting to a 6.2 (sd 5.1) % reduction by 37 h. Thirst increased from 0-13 h of FR then did not increase further (P>0.05)...
  33. Bots C, Brand H, Veerman E, Valentijn Benz M, Van Amerongen B, Valentijn R, et al. Interdialytic weight gain in patients on hemodialysis is associated with dry mouth and thirst. Kidney Int. 2004;66:1662-8 pubmed
    Patients receiving hemodialysis (HD) have to maintain a fluid-restricted diet. Severe thirst can induce noncompliance to this diet, resulting in an increase of interdialytic weight gain (IWG = weight predialysis - postdialysis) associated ..
  34. Teuchner B, Orgul S, Ulmer H, Haufschild T, Flammer J. Reduced thirst in patients with a vasospastic syndrome. Acta Ophthalmol Scand. 2004;82:738-40 pubmed
    To compare thirst, drinking behaviour, and endothelin-1 (ET-1) plasma levels between vasospastic and non-vasospastic subjects...
  35. Armstrong L. Hydration assessment techniques. Nutr Rev. 2005;63:S40-54 pubmed
    ..assessment techniques of isotope dilution, neutron activation analysis, bioelectrical impedance, body mass change, thirst, tracer appearance, hematologic indices, and urinary markers...
  36. Thornton S. Thirst and hydration: physiology and consequences of dysfunction. Physiol Behav. 2010;100:15-21 pubmed publisher
    ..The constant supply of water (and sodium) for cardiovascular function is the role of thirst and sodium appetite and kidney function...
  37. Wilson W, Roques B, Llorens Cortes C, Speth R, Harding J, Wright J. Roles of brain angiotensins II and III in thirst and sodium appetite. Brain Res. 2005;1060:108-17 pubmed
    ..icv) infused aminopeptidase-resistant analogs of angiotensin II (AngII) and angiotensin III (AngIII) on thirst and sodium appetite...
  38. Wood N, Goodman A, van der Burg J, Gazeau V, Brundin P, Björkqvist M, et al. Increased thirst and drinking in Huntington's disease and the R6/2 mouse. Brain Res Bull. 2008;76:70-9 pubmed publisher
    ..Because the osmoreceptors regulating thirst are situated in the circumventricular region of the hypothalamus, we were interested in whether altered thirst is ..
  39. Rostoker G, Griuncelli M, Benmaadi A. Candesartan cilexetil on regular hemodialysis: inability to reduce excessive thirst, but good tolerance and efficacy in hypertensive patients. Ren Fail. 2006;28:283-6 pubmed
    ..Recent studies show that candesartan cilexetil regulates thirst and hypertension in rodents, via cerebral AT1 receptor blockade...
  40. Mecawi A, Lepletier A, Araujo I, Olivares E, Reis L. Assessment of brain AT1-receptor on the nocturnal basal and angiotensin-induced thirst and sodium appetite in ovariectomised rats. J Renin Angiotensin Aldosterone Syst. 2007;8:169-75 pubmed publisher
    Considering the controversial data regarding the role of the brain renin-angiotensin system (RAS) on the thirst and sodium appetite in ovariectomised rats, we aimed to evaluate the role of the brain angiotensin II (Ang II) AT1-receptor on ..
  41. de Magalhães Nunes A, Badaue Passos D, Ventura R, Guedes D, Araújo J, Granadeiro P, et al. Sertraline, a selective serotonin reuptake inhibitor, affects thirst, salt appetite and plasma levels of oxytocin and vasopressin in rats. Exp Physiol. 2007;92:913-22 pubmed
    ..These data constitute the first evidence that chronic SERT treatment affects water and sodium intake in rats. These effects seem to be related to the hyponatraemia caused by the higher plasma levels of AVP and OT. ..
  42. Kenney W, Chiu P. Influence of age on thirst and fluid intake. Med Sci Sports Exerc. 2001;33:1524-32 pubmed
    ..in a warm environment (all of which combine hypovolemia and hyperosmolality), older adults exhibit decreased thirst sensation and reduced fluid intake...
  43. D anci K, Constant F, Rosenberg I. Hydration and cognitive function in children. Nutr Rev. 2006;64:457-64 pubmed
    ..Additionally, children have different thirst sensitivities and body cooling mechanisms than adults...
  44. Masajtis Zagajewska A, Nowicki M. Influence of dual blockade of the renin-angiotensin system on thirst in hemodialysis patients. Nephron Clin Pract. 2009;112:c242-7 pubmed publisher
    ..Clinical studies on the effect of an angiotensin-converting enzyme inhibitor (ACEI) on xerostomia and thirst in chronic hemodialysis (HD) patients were scarce and gave contradictory results...
  45. Gupta S, Cheetham T, Lambert H, Roberts C, Bourn D, Coulthard M, et al. Thirst perception and arginine vasopressin production in a kindred with an activating mutation of the type 2 vasopressin receptor: the pathophysiology of nephrogenic syndrome of inappropriate antidiuresis. Eur J Endocrinol. 2009;161:503-8 pubmed publisher
    ..individuals had a subnormal ability to excrete a water load with mother also demonstrating a heightened sense of thirst at low serum osmolalities. Mother and child were found to have the previously characterised activating mutation (p...
  46. Edmonds C, Burford D. Should children drink more water?: the effects of drinking water on cognition in children. Appetite. 2009;52:776-779 pubmed publisher
    ..002), and they performed better on visual attention tasks (letter cancellation, p=0.02; spot the difference memory tasks, ps=0.019 and 0.014). ..
  47. Bots C, Brand H, Veerman E, Korevaar J, Valentijn Benz M, Bezemer P, et al. Chewing gum and a saliva substitute alleviate thirst and xerostomia in patients on haemodialysis. Nephrol Dial Transplant. 2005;20:578-84 pubmed
    ..Recently, we demonstrated that xerostomia and thirst were positively correlated with IWG in HD patients...
  48. Bourque C. Central mechanisms of osmosensation and systemic osmoregulation. Nat Rev Neurosci. 2008;9:519-31 pubmed publisher
    ..Here, recent advances in our understanding of the molecular, cellular and network mechanisms that mediate the central control of osmotic homeostasis in mammals are reviewed. ..
  49. Mecawi A, Lepletier A, Araujo I, Fonseca F, Reis L. Oestrogenic influence on brain AT1 receptor signalling on the thirst and sodium appetite in osmotically stimulated and sodium-depleted female rats. Exp Physiol. 2008;93:1002-10 pubmed publisher
    The present work was carried out to investigate the role of angiotensin II type 1 (AT(1)) receptors in nocturnal thirst and sodium appetite induced by classical models of osmotic and sodium depletion challenges in ovariectomized rats ..
  50. Ciura S, Bourque C. Transient receptor potential vanilloid 1 is required for intrinsic osmoreception in organum vasculosum lamina terminalis neurons and for normal thirst responses to systemic hyperosmolality. J Neurosci. 2006;26:9069-75 pubmed
    ..These findings indicate that OVLT neurons act as primary osmoreceptors and that a product of the trpv1 gene is required for osmosensory transduction...
  51. Morita T, Tei Y, Tsunoda J, Inoue S, Chihara S. Determinants of the sensation of thirst in terminally ill cancer patients. Support Care Cancer. 2001;9:177-86 pubmed
    While a sensation of thirst causes severe distress for a certain proportion of cancer patients in the terminal stage, the factors contributing to this symptom have not been established...
  52. Parsons L, Denton D, Egan G, McKinley M, Shade R, Lancaster J, et al. Neuroimaging evidence implicating cerebellum in support of sensory/cognitive processes associated with thirst. Proc Natl Acad Sci U S A. 2000;97:2332-6 pubmed
    ..we examined the effects on the cerebellum of the rise of plasma sodium concentration and the emergence of thirst in 10 healthy adults...
  53. Stachenfeld N, Dipietro L, Nadel E, Mack G. Mechanism of attenuated thirst in aging: role of central volume receptors. Am J Physiol. 1997;272:R148-57 pubmed
    To test the hypothesis that the inhibitory action of central blood volume expansion on thirst and renal fluid regulation is attenuated with aging, we monitored the drinking and renal responses of dehydrated older (70 +/- 2 yr, n = 6) and ..