agnosia

Summary

Summary: Loss of the ability to comprehend the meaning or recognize the importance of various forms of stimulation that cannot be attributed to impairment of a primary sensory modality. Tactile agnosia is characterized by an inability to perceive the shape and nature of an object by touch alone, despite unimpaired sensation to light touch, position, and other primary sensory modalities.

Top Publications

  1. Behrmann M, Williams P. Impairments in part-whole representations of objects in two cases of integrative visual agnosia. Cogn Neuropsychol. 2007;24:701-30 pubmed
    ..This study reports a series of experiments that examine the ability of two such patients with this form of agnosia (integrative agnosia; IA), S.M. and C.R...
  2. Riddoch M, Humphreys G, Akhtar N, Allen H, Bracewell R, Schofield A. A tale of two agnosias: distinctions between form and integrative agnosia. Cogn Neuropsychol. 2008;25:56-92 pubmed publisher
    The performance of two patients with visual agnosia was compared across a number of tests examining visual processing. The patients were distinguished by having dorsal and medial ventral extrastriate lesions...
  3. Coslett H, Lie E. Simultanagnosia: effects of semantic category and repetition blindness. Neuropsychologia. 2008;46:1853-63 pubmed publisher
    ..More generally, these data are consistent with the claim that the posterior parietal cortex is crucial for individuating a stimulus by computing its unique spatio-temporal characteristics...
  4. Duchaine B, Germine L, Nakayama K. Family resemblance: ten family members with prosopagnosia and within-class object agnosia. Cogn Neuropsychol. 2007;24:419-30 pubmed publisher
    ..These results strongly suggest the existence of a genetic condition leading to a selective deficit of visual recognition...
  5. Hiraoka K, Suzuki K, Hirayama K, Mori E. Visual agnosia for line drawings and silhouettes without apparent impairment of real-object recognition: a case report. Behav Neurol. 2009;21:187-92 pubmed publisher
    We report on a patient with visual agnosia for line drawings and silhouette pictures following cerebral infarction in the region of the right posterior cerebral artery...
  6. Turnbull O, Driver J, McCarthy R. 2D but not 3D: pictorial-depth deficits in a case of visual agnosia. Cortex. 2004;40:723-38 pubmed
    Patients with visual agnosia exhibit acquired impairments in visual object recognition, that may or may not involve deficits in low-level perceptual abilities...
  7. Masullo C, Piccininni C, Quaranta D, Vita M, Gaudino S, Gainotti G. Selective impairment of living things and musical instruments on a verbal 'Semantic Knowledge Questionnaire' in a case of apperceptive visual agnosia. Brain Cogn. 2012;80:155-9 pubmed publisher
    Semantic memory was investigated in a patient (MR) affected by a severe apperceptive visual agnosia, due to an ischemic cerebral lesion, bilaterally affecting the infero-mesial parts of the temporo-occipital cortices...
  8. Giovagnoli A, Aresi A, Reati F, Riva A, Gobbo C, Bizzi A. The neuropsychological and neuroradiological correlates of slowly progressive visual agnosia. Neurol Sci. 2009;30:123-31 pubmed publisher
    The case of a 64-year-old woman affected by slowly progressive visual agnosia is reported aiming to describe specific cognitive-brain relationships...
  9. Karnath H, Rüter J, Mandler A, Himmelbach M. The anatomy of object recognition--visual form agnosia caused by medial occipitotemporal stroke. J Neurosci. 2009;29:5854-62 pubmed publisher
    ..visual action versus perception in patients with optic ataxia on the one hand and patients with visual form agnosia (VFA) on the other...

More Information

Publications67

  1. Moro V, Urgesi C, Pernigo S, Lanteri P, Pazzaglia M, Aglioti S. The neural basis of body form and body action agnosia. Neuron. 2008;60:235-46 pubmed publisher
    ..Our study reports two category-specific visual deficits, called body form and body action agnosia, and highlights their neural underpinnings.
  2. Demeyere N, Rzeskiewicz A, Humphreys K, Humphreys G. Automatic statistical processing of visual properties in simultanagnosia. Neuropsychologia. 2008;46:2861-4 pubmed publisher
    ..Overall, this study suggests that automatic statistical processing of color and size is possible in simultanagnosia...
  3. Gilaie Dotan S, Perry A, Bonneh Y, Malach R, Bentin S. Seeing with profoundly deactivated mid-level visual areas: non-hierarchical functioning in the human visual cortex. Cereb Cortex. 2009;19:1687-703 pubmed publisher
    ..Here we qualify this notion reporting case LG, a rare case of developmental object agnosia and prosopagnosia...
  4. Carey D, Dijkerman H, Murphy K, Goodale M, Milner A. Pointing to places and spaces in a patient with visual form agnosia. Neuropsychologia. 2006;44:1584-94 pubmed
    ..It is possible that D.F.'s degraded performance reflects a relative (though not complete) preservation of categorical coding within the ventral stream, despite a loss of coordinate coding there...
  5. Foulsham T, Barton J, Kingstone A, Dewhurst R, Underwood G. Fixation and saliency during search of natural scenes: the case of visual agnosia. Neuropsychologia. 2009;47:1994-2003 pubmed publisher
    ..In the present investigation, the eye movements of a patient with visual agnosia were recorded while she searched for objects within photographs of natural scenes and compared to those made by ..
  6. Cavina Pratesi C, Kentridge R, Heywood C, Milner A. Separate channels for processing form, texture, and color: evidence from FMRI adaptation and visual object agnosia. Cereb Cortex. 2010;20:2319-32 pubmed publisher
    ..These latter areas appear to correspond to those associated with the perception of complex stimuli such as faces and places...
  7. Anema H, Overvliet K, Smeets J, Brenner E, Dijkerman H. Integration of tactile input across fingers in a patient with finger agnosia. Neuropsychologia. 2011;49:138-46 pubmed publisher
    Finger agnosia has been described as an inability to explicitly individuate between the fingers, which is possibly due to fused neural representations of these fingers...
  8. Wilson R, Schneider J, Arnold S, Tang Y, Boyle P, Bennett D. Olfactory identification and incidence of mild cognitive impairment in older age. Arch Gen Psychiatry. 2007;64:802-8 pubmed
    ..Mild cognitive impairment (MCI) is often a precursor to Alzheimer disease, but knowledge about factors that predict its development is limited...
  9. Hömke L, Amunts K, Bönig L, Fretz C, Binkofski F, Zilles K, et al. Analysis of lesions in patients with unilateral tactile agnosia using cytoarchitectonic probabilistic maps. Hum Brain Mapp. 2009;30:1444-56 pubmed publisher
    ..The procedure is demonstrated in three patients suffering from aperceptive tactile agnosia of the right hand due to chronic infarction of the left parietal cortex...
  10. Appelros P, Karlsson G, Hennerdal S. Anosognosia versus unilateral neglect. Coexistence and their relations to age, stroke severity, lesion site and cognition. Eur J Neurol. 2007;14:54-9 pubmed
    ..For anosognosia, lesion location appears to be less important. Anosognosia also tends to occur with larger strokes...
  11. Jehkonen M, Laihosalo M, Kettunen J. Anosognosia after stroke: assessment, occurrence, subtypes and impact on functional outcome reviewed. Acta Neurol Scand. 2006;114:293-306 pubmed
  12. Vignolo L. Music agnosia and auditory agnosia. Dissociations in stroke patients. Ann N Y Acad Sci. 2003;999:50-7 pubmed
    ..and an experimental study were carried out in search of dissociations between the recognition of music (music agnosia) and that of environmental sounds (auditory agnosia) in stroke patients...
  13. Bridge H, Thomas O, Minini L, Cavina Pratesi C, Milner A, Parker A. Structural and functional changes across the visual cortex of a patient with visual form agnosia. J Neurosci. 2013;33:12779-91 pubmed publisher
    Loss of shape recognition in visual-form agnosia occurs without equivalent losses in the use of vision to guide actions, providing support for the hypothesis of two visual systems (for "perception" and "action")...
  14. Biran I, Coslett H. Visual agnosia. Curr Neurol Neurosci Rep. 2003;3:508-12 pubmed
    ..Visual agnosia is defined as impaired object recognition that cannot be attributed to visual loss, language impairment, or a ..
  15. James T, Culham J, Humphrey G, Milner A, Goodale M. Ventral occipital lesions impair object recognition but not object-directed grasping: an fMRI study. Brain. 2003;126:2463-75 pubmed
    D.F., a patient with severe visual form agnosia, has been the subject of extensive research during the past decade...
  16. Riddoch M, Humphreys G. Visual agnosia. Neurol Clin. 2003;21:501-20 pubmed
    ..In some cases, mild damage to stored perceptual knowledge also generates problems that are more severe on naming than on recognition and more severe for some categories of objects than others...
  17. Zhang Q, Kaga K, Hayashi A. Auditory agnosia due to long-term severe hydrocephalus caused by spina bifida - specific auditory pathway versus nonspecific auditory pathway. Acta Otolaryngol. 2011;131:787-92 pubmed publisher
    A 27-year-old female showed auditory agnosia after long-term severe hydrocephalus due to congenital spina bifida...
  18. Yamamoto T, Kikuchi T, Nagae J, Ogata K, Ogawa M, Kawai M. [Dysprosody associated with environmental auditory sound agnosia in right temporal lobe hypoperfusion--a case report]. Rinsho Shinkeigaku. 2004;44:28-33 pubmed
    A 60-year-old right-handed man showed dysprosody and agnosia for environmental sounds. His mother tongue was Japanese, and he could not speak foreign languages...
  19. Behrmann M, Peterson M, Moscovitch M, Suzuki S. Independent representation of parts and the relations between them: evidence from integrative agnosia. J Exp Psychol Hum Percept Perform. 2006;32:1169-84 pubmed
    ..S. M., an individual with integrative agnosia, and neurologically intact ("normal") individuals learned initially to identify 4 target objects ..
  20. Charles Leek E, Patterson C, Paul M, Rafal R, Cristino F. Eye movements during object recognition in visual agnosia. Neuropsychologia. 2012;50:2142-53 pubmed publisher
    ..reports the first ever detailed study about eye movement patterns during single object recognition in visual agnosia. Eye movements were recorded in a patient with an integrative agnosic deficit during two recognition tasks: ..
  21. Dalrymple K, Kingstone A, Barton J. Seeing trees OR seeing forests in simultanagnosia: attentional capture can be local or global. Neuropsychologia. 2007;45:871-5 pubmed
    ..Capture likely occurs because of a pathological restriction and/or rigidity of attention, but the type of capture depends upon the competitive balance between global and local salience...
  22. Clavagnier S, Fruhmann Berger M, Klockgether T, Moskau S, Karnath H. Restricted ocular exploration does not seem to explain simultanagnosia. Neuropsychologia. 2006;44:2330-6 pubmed
    ..Our data rather suggest a role of parietal cortex in visual gestalt perception that is beyond its role of directing attention towards relevant objects...
  23. Matthews B, Chang C, De May M, Engstrom J, Miller B. Pleasurable emotional response to music: a case of neurodegenerative generalized auditory agnosia. Neurocase. 2009;15:248-59 pubmed publisher
    ..Here we present the case of a young man with auditory agnosia as the consequence of cortical neurodegeneration who continues to experience pleasure when exposed to music...
  24. Behrmann M, Marotta J, Gauthier I, Tarr M, McKeeff T. Behavioral change and its neural correlates in visual agnosia after expertise training. J Cogn Neurosci. 2005;17:554-68 pubmed
    b>Agnosia, the impairment in object and face recognition despite intact vision and intelligence, is one of the most intriguing and debilitating neuropsychological deficits. The goal of this study was to determine whether S.M...
  25. Delvenne J, Seron X, Coyette F, Rossion B. Evidence for perceptual deficits in associative visual (prosop)agnosia: a single-case study. Neuropsychologia. 2004;42:597-612 pubmed
    Associative visual agnosia is classically defined as normal visual perception stripped of its meaning [Archiv für Psychiatrie und Nervenkrankheiten 21 (1890) 22/English translation: Cognitive Neuropsychol...
  26. Konen C, Behrmann M, Nishimura M, Kastner S. The functional neuroanatomy of object agnosia: a case study. Neuron. 2011;71:49-60 pubmed publisher
    ..Finally, functional neural plasticity is possible even when a cortical lesion is sustained in adulthood...
  27. Goll J, Crutch S, Warren J. Central auditory disorders: toward a neuropsychology of auditory objects. Curr Opin Neurol. 2010;23:617-27 pubmed publisher
    ..Here we review current evidence concerning the phenomenology, mechanisms and brain substrates of auditory agnosias and related disorders of auditory object processing...
  28. Schenk T, Milner A. Concurrent visuomotor behaviour improves form discrimination in a patient with visual form agnosia. Eur J Neurosci. 2006;24:1495-503 pubmed
    ..This suggests that shape information per se is not used for this grasping task...
  29. Rice N, McIntosh R, Schindler I, Mon Williams M, Demonet J, Milner A. Intact automatic avoidance of obstacles in patients with visual form agnosia. Exp Brain Res. 2006;174:176-88 pubmed
    ..We tested this idea in two studies involving patients with visual form agnosia resulting from bilateral ventral-stream damage...
  30. Huberle E, Karnath H. Global shape recognition is modulated by the spatial distance of local elements--evidence from simultanagnosia. Neuropsychologia. 2006;44:905-11 pubmed
    ..The findings seem to argue against a deficit in visual working memory capacity as the primary deficit in simultanagnosia. However, further research is necessary to investigate alternative interpretations...
  31. McIntosh R, Dijkerman H, Mon Williams M, Milner A. Grasping what is graspable: evidence from visual form agnosia. Cortex. 2004;40:695-702 pubmed
    Patient DF has profound visual form agnosia. Despite this, she has no problem adjusting her finger-thumb grip aperture to the width of objects when reaching to grasp them...
  32. Orfei M, Robinson R, Prigatano G, Starkstein S, Rusch N, Bria P, et al. Anosognosia for hemiplegia after stroke is a multifaceted phenomenon: a systematic review of the literature. Brain. 2007;130:3075-90 pubmed
    ..We highlight the need for a multidimensional assessment procedure and suggest some potentially productive directions for future research about unawareness of illness...
  33. Saygin A, Leech R, Dick F. Nonverbal auditory agnosia with lesion to Wernicke's area. Neuropsychologia. 2010;48:107-13 pubmed publisher
    ..We verified that the patient exhibited persistent and severe auditory agnosia for nonverbal sounds in the absence of verbal comprehension deficits or peripheral hearing problems...
  34. Cavina Pratesi C, Kentridge R, Heywood C, Milner A. Separate processing of texture and form in the ventral stream: evidence from FMRI and visual agnosia. Cereb Cortex. 2010;20:433-46 pubmed publisher
    ..We also tested 2 patients with visual object agnosia, one of whom (DF) performed well on the texture task but at chance on the shape task, whereas the other (MS) ..
  35. van Zandvoort M, Nijboer T, de Haan E. Developmental colour agnosia. Cortex. 2007;43:750-7 pubmed
    Colour agnosia concerns the inability to recognise colours despite intact colour perception, semantic memory for colour information, and colour naming...
  36. Wolk D, Coslett H, Glosser G. The role of sensory-motor information in object recognition: evidence from category-specific visual agnosia. Brain Lang. 2005;94:131-46 pubmed
    ..representations in object recognition was investigated in experiments involving AD, a patient with mild visual agnosia who was impaired in the recognition of visually presented living as compared to non-living entities...
  37. Anaki D, Kaufman Y, Freedman M, Moscovitch M. Associative (prosop)agnosia without (apparent) perceptual deficits: a case-study. Neuropsychologia. 2007;45:1658-71 pubmed
    In associative agnosia early perceptual processing of faces or objects are considered to be intact, while the ability to access stored semantic information about the individual face or object is impaired...
  38. Nan Y, Sun Y, Peretz I. Congenital amusia in speakers of a tone language: association with lexical tone agnosia. Brain. 2010;133:2635-42 pubmed publisher
    ..Six showed marked impairments, displaying what could be called lexical tone agnosia, but had normal tone production...
  39. Della Sala S, Cocchini G, Beschin N, Cameron A. VATA-m: Visual-Analogue Test assessing Anosognosia for motor impairment. Clin Neuropsychol. 2009;23:406-27 pubmed publisher
    ..In addition, the test overcomes some of the limitations of the existing structured interviews and questionnaires, by enhancing reliability, improving data interpretation and diagnosis, and enabling assessment of patients with aphasia...
  40. Small D, Bernasconi N, Bernasconi A, Sziklas V, Jones Gotman M. Gustatory agnosia. Neurology. 2005;64:311-7 pubmed
    To report the assessment of a patient exhibiting gustatory agnosia.
  41. Hattiangadi N, Pillion J, Slomine B, Christensen J, Trovato M, Speedie L. Characteristics of auditory agnosia in a child with severe traumatic brain injury: a case report. Brain Lang. 2005;92:12-25 pubmed
    We present a case that is unusual in many respects from other documented incidences of auditory agnosia, including the mechanism of injury, age of the individual, and location of neurological insult...
  42. Pisella L, Binkofski F, Lasek K, Toni I, Rossetti Y. No double-dissociation between optic ataxia and visual agnosia: multiple sub-streams for multiple visuo-manual integrations. Neuropsychologia. 2006;44:2734-48 pubmed
    ..The "double-dissociation" between visual agnosia (VA), a deficit of visual recognition, and optic ataxia (OA), a deficit of visuo-manual guidance, considered as ..
  43. Satoh M, Takeda K, Kuzuhara S. A case of auditory agnosia with impairment of perception and expression of music: cognitive processing of tonality. Eur Neurol. 2007;58:70-7 pubmed
    ..We describe a patient with auditory agnosia and expressive amusia that developed after a bilateral infarction of the temporal lobes...
  44. Kiper D, Zesiger P, Maeder P, Deonna T, Innocenti G. Vision after early-onset lesions of the occipital cortex: I. Neuropsychological and psychophysical studies. Neural Plast. 2002;9:1-25 pubmed
    ..In FJ (age 18:9 to 20:6 y), who is more impaired, the recovery, if any, was less. ..
  45. Chanoine V, Ferreira C, Demonet J, Nespoulous J, Poncet M. Optic aphasia with pure alexia: a mild form of visual associative agnosia? A case study. Cortex. 1998;34:437-48 pubmed
    ..This symmetric performance between object and letter processing may also constitute a mild form of visual associative agnosia.
  46. Tucha O, Steup A, Smely C, Lange K. Toe agnosia in Gerstmann syndrome. J Neurol Neurosurg Psychiatry. 1997;63:399-403 pubmed
    The following case report presents a patient exhibiting Gerstmann syndrome accompanied by toe agnosia. A 72 year old right handed woman had a focal lesion in the angular gyrus of the left hemisphere which was caused by a glioblastoma ..
  47. Behrmann M, Winocur G, Moscovitch M. Dissociation between mental imagery and object recognition in a brain-damaged patient. Nature. 1992;359:636-7 pubmed
    ..Here we present evidence to the contrary from a patient with severely impaired object recognition (visual object agnosia) but with normal mental imagery...
  48. Dijkerman H, Milner A, Carey D. Motion parallax enables depth processing for action in a visual form agnosic when binocular vision is unavailable. Neuropsychologia. 1999;37:1505-10 pubmed
    ..They further indicate that orientation in depth can be computed from motion parallax just as well as from binocular cues in the absence of a normally functioning ventral stream. ..
  49. Mon Williams M, McIntosh R, Milner A. Vertical gaze angle as a distance cue for programming reaching: insights from visual form agnosia II (of III). Exp Brain Res. 2001;139:137-42 pubmed
    It has been shown that a patient with visual form agnosia (DF) relies predominantly on vergence information when gauging target distance in an open-loop pointing task...
  50. Joy P, Brunsdon R. Visual agnosia and prosopagnosia in childhood: a prospective case study. Child Neuropsychol. 2002;8:1-15 pubmed
    ..His reading and spelling are developing normally. The nature of his deficits and his progress are discussed within a cognitive neuropsychological framework...
  51. Takahashi N, Kawamura M. Pure topographical disorientation--the anatomical basis of landmark agnosia. Cortex. 2002;38:717-25 pubmed
    We used MRI studies of four patients to investigate the lesions responsible for landmark agnosia. A detailed investigation of the relationship between the symptoms and the lesions suggests that the right posterior part of the ..
  52. Mendez M, Ghajarnia M. Agnosia for familiar faces and odors in a patient with right temporal lobe dysfunction. Neurology. 2001;57:519-21 pubmed
    ..Neuroimaging revealed temporal lobe changes, especially on the right. Right temporal lesions may produce face and odor agnosia by preventing perceptual familiarity units from accessing semantic associations.
  53. Mon Williams M, Tresilian J, McIntosh R, Milner A. Monocular and binocular distance cues: insights from visual form agnosia I (of III). Exp Brain Res. 2001;139:127-36 pubmed
    ..We investigated the cues used for the representation of personal space in a patient with visual form agnosia (DF)...
  54. Aguirre G, D ESPOSITO M. Topographical disorientation: a synthesis and taxonomy. Brain. 1999;122 ( Pt 9):1613-28 pubmed
    ..The conflicting claims of previous reviews of this area are also considered and addressed...
  55. Marotta J, Behrmann M, Goodale M. The removal of binocular cues disrupts the calibration of grasping in patients with visual form agnosia. Exp Brain Res. 1997;116:113-21 pubmed
    ..Individuals with visual form agnosia, whose perceptual systems are compromised but who have intact visuomotor control, were examined to determine ..
  56. Giannakopoulos P, Gold G, Duc M, Michel J, Hof P, Bouras C. Neuroanatomic correlates of visual agnosia in Alzheimer's disease: a clinicopathologic study. Neurology. 1999;52:71-7 pubmed
    To examine the neuroanatomic correlates of visual agnosia in AD.
  57. Westwood D, Danckert J, Servos P, Goodale M. Grasping two-dimensional images and three-dimensional objects in visual-form agnosia. Exp Brain Res. 2002;144:262-7 pubmed
    ..We asked a neurological patient with visual-form agnosia (patient D.F.) to grasp 3D objects and 2D images of the same objects and to estimate their sizes manually. D.F...
  58. Mendez M, Cherrier M. Agnosia for scenes in topographagnosia. Neuropsychologia. 2003;41:1387-95 pubmed
    Topographagnosia is most commonly attributed to an agnosia for landmarks...