consciousness disorders

Summary

Summary: Organic mental disorders in which there is impairment of the ability to maintain awareness of self and environment and to respond to environmental stimuli. Dysfunction of the cerebral hemispheres or brain stem RETICULAR FORMATION may result in this condition.

Top Publications

  1. Chatelle C, Chennu S, Noirhomme Q, Cruse D, Owen A, Laureys S. Brain-computer interfacing in disorders of consciousness. Brain Inj. 2012;26:1510-22 pubmed publisher
    ..These findings have highlighted the potential for the development of simple brain-computer interfaces (BCI) as a diagnosis in behaviourally unresponsive patients...
  2. Lechinger J, Chwala Schlegel N, Fellinger R, Donis J, Michitsch G, Pichler G, et al. Mirroring of a simple motor behavior in disorders of consciousness. Clin Neurophysiol. 2013;124:27-34 pubmed publisher
    ..We utilized a motor observation and imagination paradigm to gain new insights on preserved cognitive processing in DOC...
  3. Soddu A, Vanhaudenhuyse A, Bahri M, Bruno M, Boly M, Demertzi A, et al. Identifying the default-mode component in spatial IC analyses of patients with disorders of consciousness. Hum Brain Mapp. 2012;33:778-96 pubmed publisher
    ..We here aimed to identify the DMN in the challenging patient population of disorders of consciousness encountered following coma...
  4. Racine E, Rodrigue C, Bernat J, Riopelle R, Shemie S. Observations on the ethical and social aspects of disorders of consciousness. Can J Neurol Sci. 2010;37:758-68 pubmed
    ..We conclude by highlighting areas needing further research and collaboration...
  5. Lule D, Zickler C, Hacker S, Bruno M, Demertzi A, Pellas F, et al. Life can be worth living in locked-in syndrome. Prog Brain Res. 2009;177:339-51 pubmed publisher
    ..Novel communication devices and assistive technology now offers an increasing number of LIS patients to resume a meaningful life and an active role in society...
  6. Cologan V, Schabus M, Ledoux D, Moonen G, Maquet P, Laureys S. Sleep in disorders of consciousness. Sleep Med Rev. 2010;14:97-105 pubmed publisher
    ..At the present time the interactions of sleep and consciousness in brain-injured patients are a little studied subject but, the authors suggest, a potentially very interesting field of research...
  7. Bruno M, Fernandez Espejo D, Lehembre R, Tshibanda L, Vanhaudenhuyse A, Gosseries O, et al. Multimodal neuroimaging in patients with disorders of consciousness showing "functional hemispherectomy". Prog Brain Res. 2011;193:323-33 pubmed publisher
  8. Goldfine A, Victor J, Conte M, Bardin J, Schiff N. Determination of awareness in patients with severe brain injury using EEG power spectral analysis. Clin Neurophysiol. 2011;122:2157-68 pubmed publisher
    ..To determine whether EEG spectral analysis could be used to demonstrate awareness in patients with severe brain injury...
  9. Eken C, Kartal M, Bacanli A, Eray O. Comparison of the Full Outline of Unresponsiveness Score Coma Scale and the Glasgow Coma Scale in an emergency setting population. Eur J Emerg Med. 2009;16:29-36 pubmed publisher
    ..We aimed to compare FOUR Score and GCS in the emergency setting...

More Information

Publications62

  1. Bernat J. Chronic consciousness disorders. Annu Rev Med. 2009;60:381-92 pubmed publisher
  2. Smith E, Delargy M. Locked-in syndrome. BMJ. 2005;330:406-9 pubmed
  3. Neumann N, Kotchoubey B. Assessment of cognitive functions in severely paralysed and severely brain-damaged patients: neuropsychological and electrophysiological methods. Brain Res Brain Res Protoc. 2004;14:25-36 pubmed
    ..These procedures can be performed directly at a patient's bedside (at home or in a hospital) and applied for assessment of cognitive functions even in patients without residual motor function...
  4. Gill M, Martens K, Lynch E, Salih A, Green S. Interrater reliability of 3 simplified neurologic scales applied to adults presenting to the emergency department with altered levels of consciousness. Ann Emerg Med. 2007;49:403-7, 407.e1 pubmed
  5. Fairley D, Timothy J, Donaldson Hugh M, Stone M, Warren D, Cosgrove J. Using a coma scale to assess patient consciousness levels. Nurs Times. 2005;101:38-41 pubmed
    ..This article outlines the Leeds Teaching Hospitals NHS Trust's guidelines to assist practitioners with the practical aspects of carrying out and interpreting the scale...
  6. Giacino J, Smart C. Recent advances in behavioral assessment of individuals with disorders of consciousness. Curr Opin Neurol. 2007;20:614-9 pubmed
    ..The current review discusses recent advances in understanding the strengths and weaknesses of this methodology...
  7. Schiff N. Multimodal neuroimaging approaches to disorders of consciousness. J Head Trauma Rehabil. 2006;21:388-97 pubmed
    ..Although limited in number, available studies already provide important insights into underlying brain mechanisms that may help guide development of such assessment strategies...
  8. Kotchoubey B, Lang S, Mezger G, Schmalohr D, Schneck M, Semmler A, et al. Information processing in severe disorders of consciousness: vegetative state and minimally conscious state. Clin Neurophysiol. 2005;116:2441-53 pubmed
    ..However, it remains unclear whether the reported patients were representative for PVS population or just some exceptional cases...
  9. Miyata S, Mikami T, Minamida Y, Akiyama Y, Houkin K. Suprasellar hemangioblastoma. J Neuroophthalmol. 2008;28:325-6 pubmed publisher
    ..The hypothalamus appeared to be the origin of the mass, which proved to be hemangioblastoma, a rare tumor in this location...
  10. Rwebembera J, Wilson T. Altered consciousness in Ugandan hospital admissions. Trop Doct. 2009;39:240-1 pubmed publisher
  11. Zehtabchi S, Abdel Baki S, Omurtag A, Sinert R, Chari G, Malhotra S, et al. Prevalence of non-convulsive seizure and other electroencephalographic abnormalities in ED patients with altered mental status. Am J Emerg Med. 2013;31:1578-82 pubmed publisher
    ..The prevalence of non-convulsive seizure (NCS) and other electroencephalographic (EEG) abnormalities in this population is unknown...
  12. Koga S, Sekiguchi Y, Kanai K, Mutoh M, Kuwabara S. [Case of adult onset vanishing white matter disease developed after minor head trauma]. Rinsho Shinkeigaku. 2012;52:561-6 pubmed
    ..Recently, milder variants of the disease with adult onset have been reported. VWMD should be included in the differential diagnosis of leucoencephalopathy in young adults...
  13. Adam V. [Altered mental status in intensive care unit patients]. Acta Med Croatica. 2012;66:3-6 pubmed
    ..In this article, we give a brief overview of the issues related to altered mental status of intensive care unit patients...
  14. Papacocea A, Papacocea T, Danaila L, Ion D, Badarau A, Papacocea R. [Primary intracerebellar hematomas: surgical indications, prognosis]. Chirurgia (Bucur). 2010;105:805-7 pubmed
    ..the incidence of symptoms, the clinical picture was dominated by the gait disturbances, headache and consciousness disorders. From the analyzed cases, 50% had had surgical indication and 50% benefits on conservative treatment...
  15. Patel V, Schindlbeck M, Bryant S. Delayed elevation in carbamazepine concentrations after overdose: a retrospective poison center study. Am J Ther. 2013;20:602-6 pubmed publisher
    ..Initial serum carbamazepine concentrations can be misleading. Serial measurements documenting a declining carbamazepine concentration or prolonged observation are recommended when managing these overdoses. ..
  16. Bubrick E, Bromfield E, Dworetzky B. Utilization of below-the-hairline EEG in detecting subclinical seizures. Clin EEG Neurosci. 2010;41:15-8 pubmed
    ..This technique may be applicable more broadly, not just limited to centers with neurology residents...
  17. Cruzado J, Elvira de la Morena M. Coping and distress in caregivers of patients with disorders of consciousness. Brain Inj. 2013;27:793-8 pubmed publisher
    ..To study depression, anxiety, maladjustment and coping in caregivers of patients in vegetative state (VS) or minimally conscious state (MCS)...
  18. Hayashi L, Gazzotti M, Vidotto M, Jardim J. Incidence, indication and complications of postoperative reintubation after elective intracranial surgery. Sao Paulo Med J. 2013;131:158-65 pubmed
    ..Reintubation was associated with pulmonary complications, longer durations of mechanical ventilation, hospitalization and stay in the ICU, greater incidence of tracheostomy and mortality. ..
  19. Magazzini S, Nazerian P, Vanni S, Paladini B, Pepe G, Casanova B, et al. Clinical picture of meningitis in the adult patient and its relationship with age. Intern Emerg Med. 2012;7:359-64 pubmed publisher
    ..Level of consciousness is frequently altered in the older patients, when other specific signs become more rare, independent of etiology, comorbidities and clinical severity...
  20. Wong J, Goyal N, McBride W, Austin M, Deirmengian G. Head computed tomography is not useful for evaluating patients change in mental status following total joint arthroplasty. J Arthroplasty. 2014;29:1114-8 pubmed publisher
    ..5%, p < 0.001; TIA: 0% vs. 16.7%, P < .001). Advanced head imaging for evaluation of TJA patients with a change in mental status is of low yield. An algorithm for evaluation of these patients is proposed...
  21. Wilson F, Elder V, McCrudden E, Caldwell S. Analysis of Wessex Head Injury Matrix (WHIM) scores in consecutive vegetative and minimally conscious state patients. Neuropsychol Rehabil. 2009;19:754-60 pubmed publisher
    ..001) and highest rank behaviour were observed (p = .001) between initial and final WHIM assessments. Preliminary findings suggest that the WHIM is a sensitive measure of subtle changes in VS and MCS patients...
  22. Sen A, Campbell P, Yadla S, Jallo J, Sharan A. Deep brain stimulation in the management of disorders of consciousness: a review of physiology, previous reports, and ethical considerations. Neurosurg Focus. 2010;29:E14 pubmed publisher
  23. Englot D, Yang L, Hamid H, Danielson N, Bai X, Marfeo A, et al. Impaired consciousness in temporal lobe seizures: role of cortical slow activity. Brain. 2010;133:3764-77 pubmed publisher
    ..Further investigations will be needed to fully determine the role of cortical-subcortical networks in ictal neocortical dysfunction and may reveal treatments to prevent this important negative consequence of temporal lobe epilepsy...
  24. Stummer W, Tonn J, Mehdorn H, Nestler U, Franz K, Goetz C, et al. Counterbalancing risks and gains from extended resections in malignant glioma surgery: a supplemental analysis from the randomized 5-aminolevulinic acid glioma resection study. Clinical article. J Neurosurg. 2011;114:613-23 pubmed publisher
    ..Presently, the authors focus on the latter aspects in the final study population, and attempt to determine how safety might be affected by cytoreductive surgery...
  25. Shi C, Flanagan S, Samadani U. Vagus nerve stimulation to augment recovery from severe traumatic brain injury impeding consciousness: a prospective pilot clinical trial. Neurol Res. 2013;35:263-76 pubmed publisher
    ..If this study demonstrates that VNS can safely and positively impact outcome, then a larger randomized prospective crossover trial will be proposed. ..
  26. Xará D, Silva A, Mendonça J, Abelha F. Inadequate emergence after anesthesia: emergence delirium and hypoactive emergence in the Postanesthesia Care Unit. J Clin Anesth. 2013;25:439-46 pubmed publisher
    ..To evaluate the frequency, determinants, and outcome of inadequate emergence after elective surgery in the Postanesthesia Care Unit (PACU)...
  27. Zheng H, Chen Q, Xie Z, Wang D, Li M, Zhang X, et al. A retrospective research of HIV-negative cryptococcal meningoencephalitis patients with acute/subacute onset. Eur J Clin Microbiol Infect Dis. 2016;35:299-303 pubmed publisher
    ..However, the ratio of CSF glucose/blood glucose, consciousness level, and hospitalization length of the HIV-negative CM patients with acute/subacute onset should be of greater focus in the clinical work. ..
  28. Koide R, Isoo A, Ishii K, Uruha A, Bandoh M. Rheumatoid leptomeningitis: rare complication of rheumatoid arthritis. Clin Rheumatol. 2009;28:1117-9 pubmed publisher
    ..An early diagnosis of rheumatoid leptomeningitis and immediate initiation of treatment may prevent neurological sequelae...
  29. Varotto G, Fazio P, Rossi Sebastiano D, Avanzini G, Franceschetti S, Panzica F, et al. Music and emotion: an EEG connectivity study in patients with disorders of consciousness. Conf Proc IEEE Eng Med Biol Soc. 2012;2012:5206-9 pubmed publisher
  30. Butragueño Laiseca L, Oikonomopoulou N, Miranda Herrero M, Barredo Valderrama E, Vázquez López M, Jiménez de Domingo A, et al. Neurological complications after gamma-knife radiosurgery for hypothalamic hamartoma. Eur J Paediatr Neurol. 2016;20:745-9 pubmed publisher
    ..Nevertheless, despite its low incidence, if a patient presents neurological symptoms, primarily during the first year after intervention, possible complications of this type of surgery must be taken into account. ..
  31. Leonardi M, Pagani M, Giovannetti A, Raggi A, Sattin D. Burnout in healthcare professionals working with patients with disorders of consciousness. Work. 2013;45:349-56 pubmed publisher
    ..The aim of this study was to evaluate burnout among professionals working with patients with DOCs in post-acute and long-term care institutions...
  32. Icaza E, Mashour G. Altered states: psychedelics and anesthetics. Anesthesiology. 2013;119:1255-60 pubmed publisher
    ..In this article, the authors review historical examples of psychedelic experiences induced by general anesthetics and then contrast the mechanisms by which these two drug classes generate altered states of consciousness. ..
  33. Middleton P. Practical use of the Glasgow Coma Scale; a comprehensive narrative review of GCS methodology. Australas Emerg Nurs J. 2012;15:170-83 pubmed publisher
    ..Narrative review of Glasgow Coma Scale (GCS) methodology...
  34. Kojima A, Okui S. Intracranial hemorrhage as the initial presentation of disseminated intravascular coagulation in association with malignancy. J Stroke Cerebrovasc Dis. 2012;21:912.e1-3 pubmed publisher
    ..An autopsy revealed the presence of prostate and rectal cancers. This case illustrates the fact that a fatal intracranial hemorrhage can be the first manifestation of disseminated intravascular coagulation in association with malignancy...
  35. Cole J, Stellpflug S, Ellsworth H, Harris C. Reversal of quetiapine-induced altered mental status with physostigmine: a case series. Am J Emerg Med. 2012;30:950-3 pubmed publisher
    ..In 1 case, intubation was prevented. Because quetiapine toxicity is commonly encountered and the use of physostigmine in this setting is a potentially practice-altering treatment, emergency physicians should be aware of this phenomenon...
  36. Kamper L, Piroth W, Haage P. [Fournier gangrene (necrotizing fasciitis) in a woman with diabetes mellitus]. Dtsch Med Wochenschr. 2009;134:1625-8 pubmed publisher
    ..Physical examination showed a livid induration of the perineal and vaginal soft tissues with crepitations...
  37. Sánchez Medina Y, Pérez Del Rosario P, Dominguez J, Millan A. [Venous angioma with associated cerebellar haemorrhage]. Neurocirugia (Astur). 2013;24:88-92 pubmed publisher
    ..We observed hematoma in the right cerebellar hemisphere with radial tubular structures consistent with developmental venous anomaly. The hematoma was evacuated without a demonstrable other reason justifying the bleeding...
  38. Covelli V, Sattin D, Giovannetti A, Scaratti C, Willems M, Leonardi M. Caregiver's burden in disorders of consciousness: a longitudinal study. Acta Neurol Scand. 2016;134:352-359 pubmed publisher
    ..Hence, this study suggests the importance to plan strategies or targeted interventions in order to reduce the psychosocial and financial burden associated with caregiving. ..
  39. Mishara A. Kafka, paranoic doubles and the brain: hypnagogic vs. hyper-reflexive models of disrupted self in neuropsychiatric disorders and anomalous conscious states. Philos Ethics Humanit Med. 2010;5:13 pubmed publisher
    ..This contribution argues the opposite: the "self" informs our hypnagogic imagery precisely to the extent that we are not self-aware...
  40. Bian S, Zhang J, Liu W, Sun Z, Gu Z, Jiang X. [Receptor antagonist of NMDA and animal models of schizophrenia]. Fa Yi Xue Za Zhi. 2009;25:443-6 pubmed
    ..The relationship of the three blocking agents of ion channels (phencyclidine, MK-801, ketamine) and the establishment of schizophrenia animal models is reviewed in this article...
  41. Unemoto K, Yokota H. [Present state of initial treatment of neurological abnormalities and the development faculties of emergency physicians]. Brain Nerve. 2010;62:35-42 pubmed
    ..This report describes a strategy for accurate diagnosis and medical treatment of neurological abnormalities at the emergency rooms of hospitals, which are expected to provide this support...
  42. Whyte J, Nakase Richardson R, Hammond F, McNamee S, Giacino J, Kalmar K, et al. Functional outcomes in traumatic disorders of consciousness: 5-year outcomes from the National Institute on Disability and Rehabilitation Research Traumatic Brain Injury Model Systems. Arch Phys Med Rehabil. 2013;94:1855-60 pubmed publisher
    ..To characterize the 5-year outcomes of patients with traumatic brain injury (TBI) not following commands when admitted to acute inpatient rehabilitation...
  43. Saniova B, Drobny M, Drobna E, Matloobi A. Acute consciousness disorders in intensive care medicine - value of its grading for prognostic conclusion. Neuro Endocrinol Lett. 2012;33:167-76 pubmed
    ..Doctors at ICU work daily with patients with altered human consciousness. Therefore, they must recognize and manage it skilfully and use adequate approaches for definite solutions...
  44. Smith M, Reed J, Facco R, Hlaing T, McGee A, Hicks B, et al. The reliability of nonreconstructed computerized tomographic scans of the abdomen and pelvis in detecting thoracolumbar spine injuries in blunt trauma patients with altered mental status. J Bone Joint Surg Am. 2009;91:2342-9 pubmed publisher
    ..The purpose of the present study was to test the reliability of nonreconstructed computerized tomography of the abdomen and pelvis as a screening tool for thoracolumbar spine injuries in blunt trauma patients with altered mental status...
  45. Nakamura H, Tanaka T, Hiyama T, Okubo S, Kudo T, Kobayashi H, et al. Subarachnoid hemorrhage caused by ruptured dissecting aneurysm arising from the extracranial distal posterior inferior cerebellar artery--case report. Neurol Med Chir (Tokyo). 2010;50:41-4 pubmed
    ..The aneurysm was isolated and excised. Histological examination showed dissection of the aneurysm wall. Dissecting aneurysm arising from the extracranial portion of the PICA is extremely rare...
  46. Fiegler K, Liechti M, Bodmer M, Bruggisser M. [Intoxication with lithium]. Praxis (Bern 1994). 2009;98:685-90; quiz 691-2 pubmed publisher
    ..The pharmacokinetic characteristics of lithium is described and the risk factors leading to lithium intoxication and treatment of intoxication are discussed...
  47. Di Perri C, Stender J, Laureys S, Gosseries O. Functional neuroanatomy of disorders of consciousness. Epilepsy Behav. 2014;30:28-32 pubmed publisher
  48. Sommer J, Norup A, Poulsen I, Morgensen J. Cognitive activity limitations one year post-trauma in patients admitted to sub-acute rehabilitation after severe traumatic brain injury. J Rehabil Med. 2013;45:778-84 pubmed publisher
    ..To examine cognitive activity limitations and predictors of outcome 1 year post-trauma in patients admitted to sub-acute rehabilitation after severe traumatic brain injury...
  49. Tshibanda L, Vanhaudenhuyse A, Boly M, Soddu A, Bruno M, Moonen G, et al. Neuroimaging after coma. Neuroradiology. 2010;52:15-24 pubmed publisher
  50. Clauss R. Neurotransmitters in disorders of consciousness and brain damage. Med Hypotheses. 2011;77:209-13 pubmed publisher
    ..It unifies fundamentally different treatment approaches and explores the restoration of neurotransmitter function as a common theme to improve brain function after brain damage...
  51. Yang L, Shklyar I, Lee H, Ezeani C, Anaya J, Balakirsky S, et al. Impaired consciousness in epilepsy investigated by a prospective responsiveness in epilepsy scale (RES). Epilepsia. 2012;53:437-47 pubmed publisher
    ..Prior work on epileptic unconsciousness has mainly used retrospective and nonstandardized methods. Our goal was to validate and to obtain initial data using a standardized prospective testing battery...
  52. Raz A, Schwartzman D, Guindi D. Hemihypnosis, hypnosis, and the importance of knowing right from trend. Am J Clin Hypn. 2008;51:201-8 pubmed
    ..Tales are ubiquitous, however, and claims relating to the left or right hemispheres require both context and substantive data. Here we sketch the gist of brain laterality findings and their relevance to the hypnosis community...
  53. Tamai H, Kawamura Y, Watanabe E, Kanda M, Yamaguchi T, Kikuchi S, et al. [Acupuncture treatment for a patient with prolonged consciousness disturbance after a brain tumor surgery]. Masui. 2009;58:349-53 pubmed
    ..CBF showed a slight increase along with the recovery of consciousness suggesting a strong relevance between CBF and improvement of these symptoms...