apathy

Summary

Summary: Lack of emotion or emotional expression; a disorder of motivation that persists over time.

Top Publications

  1. Sicras Mainar A, Maurino J, Ruiz Beato E, Navarro Artieda R. Impact of negative symptoms on healthcare resource utilization and associated costs in adult outpatients with schizophrenia: a population-based study. BMC Psychiatry. 2014;14:225 pubmed publisher
    ..7, 1.4, 1.4 and 1.2, respectively). Negative symptoms are highly prevalent in adult outpatients with schizophrenia with a relevant economic impact on the healthcare system. ..
  2. Klaasen N, Kos C, Aleman A, Opmeer E. Apathy is related to reduced activation in cognitive control regions during set-shifting. Hum Brain Mapp. 2017;38:2722-2733 pubmed publisher
    b>Apathy is a prominent and influential symptom in several neurological and psychiatric disorders, but it also occurs in the healthy population. It has considerable impact on daily life functioning, in clinical as well as healthy samples...
  3. Jacus J. Awareness, apathy, and depression in Alzheimer's disease and mild cognitive impairment. Brain Behav. 2017;7:e00661 pubmed publisher
    ..and behavioral assessments (global cognition, executive functions, episodic memory, anxiety-depression, and apathy measures). Groups were matched for age, education, and gender...
  4. Barber T, Lawton M, Rolinski M, Evetts S, Baig F, Ruffmann C, et al. Prodromal Parkinsonism and Neurodegenerative Risk Stratification in REM Sleep Behavior Disorder. Sleep. 2017;40: pubmed publisher
    ..For all these measures except UPDRS-III, RBD and PD participants were equally impaired. Depression, anxiety, and apathy were worse in RBD compared to PD participants...
  5. Lansdall C, Coyle Gilchrist I, Jones P, Vázquez Rodríguez P, Wilcox A, Wehmann E, et al. Apathy and impulsivity in frontotemporal lobar degeneration syndromes. Brain. 2017;140:1792-1807 pubmed publisher
    b>Apathy and impulsivity are common and disabling consequences of frontotemporal lobar degeneration. They cause substantial carer distress, but their aetiology remains elusive...
  6. van Dalen J, Moll van Charante E, Nederkoorn P, van Gool W, Richard E. Poststroke apathy. Stroke. 2013;44:851-60 pubmed publisher
  7. Yang S, Hua P, Shang X, Hu R, Mo X, Pan X. Predictors of early post ischemic stroke apathy and depression: a cross-sectional study. BMC Psychiatry. 2013;13:164 pubmed publisher
    b>Apathy and depression are important neuropsychiatric disorders that can occur after a stroke but the etiology and risk factors are not well understood...
  8. Jang S, Kwon H. Apathy Due to Injury of the Prefrontocaudate Tract Following Mild Traumatic Brain Injury. Am J Phys Med Rehabil. 2017;96:e130-e133 pubmed publisher
    In this study, we report on a patient who developed apathy resulting from injury to the prefrontocaudate tract following mild traumatic brain injury (TBI), which was observed on diffusion tensor tractography (DTT)...
  9. Kolanowski A, Boltz M, Galik E, Gitlin L, Kales H, Resnick B, et al. Determinants of behavioral and psychological symptoms of dementia: A scoping review of the evidence. Nurs Outlook. 2017;65:515-529 pubmed publisher
    ..exists for the patient, caregiver and environmental determinants of five specific BPSD: aggression, agitation, apathy, depression and psychosis? An a priori review protocol was developed; 692 of 6013 articles retrieved in the search ..

More Information

Publications15

  1. Dujardin K, Defebvre L. Apathy in Parkinson disease: what are the underlying mechanisms?. Neurology. 2012;79:1082-3 pubmed publisher
  2. Marshall G, Donovan N, Lorius N, Gidicsin C, Maye J, Pepin L, et al. Apathy is associated with increased amyloid burden in mild cognitive impairment. J Neuropsychiatry Clin Neurosci. 2013;25:302-7 pubmed publisher
    b>Apathy is the most common neuropsychiatric symptom in mild cognitive impairment (MCI) and Alzheimer's disease (AD) dementia...
  3. Geda Y, Roberts R, Mielke M, Knopman D, Christianson T, Pankratz V, et al. Baseline neuropsychiatric symptoms and the risk of incident mild cognitive impairment: a population-based study. Am J Psychiatry. 2014;171:572-81 pubmed publisher
    ..Agitation (hazard ratio=3.06, 95% CI=1.89-4.93), apathy (hazard ratio=2.26, 95% CI=1.49-3.41), anxiety (hazard ratio=1.87, 95% CI=1.28-2.73), irritability (hazard ratio=1...
  4. Foley J, Foltynie T, Zrinzo L, Hyam J, Limousin P, Cipolotti L. Apathy and Reduced Speed of Processing Underlie Decline in Verbal Fluency following DBS. Behav Neurol. 2017;2017:7348101 pubmed publisher
    ..In contrast, greater decline in verbal fluency was associated with higher levels of apathy at baseline, which was not associated with changes in cognitive speed. Discussion...
  5. Lohner V, Brookes R, Hollocks M, Morris R, Markus H. Apathy, but not depression, is associated with executive dysfunction in cerebral small vessel disease. PLoS ONE. 2017;12:e0176943 pubmed publisher
    To determine the prevalence of apathy and depression in cerebral small vessel disease (SVD), and the relationships between both apathy and depression with cognition...
  6. Nijsten J, Leontjevas R, Pat El R, Smalbrugge M, Koopmans R, Gerritsen D. Apathy: Risk Factor for Mortality in Nursing Home Patients. J Am Geriatr Soc. 2017;65:2182-2189 pubmed publisher
    To determine the prognostic value of apathy for mortality in patients of somatic (SC) and dementia special care (DSC) nursing home (NH) units...