histoplasmosis

Summary

Summary: Infection resulting from exposure to the fungus HISTOPLASMA. It is worldwide in distribution and particularly common in the central and eastern states, especially areas around the Ohio and Mississippi River valleys.

Top Publications

  1. Swartzentruber S, Rhodes L, Kurkjian K, Zahn M, Brandt M, Connolly P, et al. Diagnosis of acute pulmonary histoplasmosis by antigen detection. Clin Infect Dis. 2009;49:1878-82 pubmed publisher
    Antigen detection, which has proven useful in diagnosis of disseminated histoplasmosis, has not been studied in acute pulmonary histoplasmosis (APH)...
  2. Gutierrez M, Canton A, Connolly P, Zarnowski R, Wheat L. Detection of Histoplasma capsulatum antigen in Panamanian patients with disseminated histoplasmosis and AIDS. Clin Vaccine Immunol. 2008;15:681-3 pubmed publisher
    b>Histoplasmosis is a common endemic mycosis in the Americas, often causing severe disease in patients with AIDS...
  3. Steiner S, Kleiman M, Corkins M, Christenson J, Wheat L. Ileocecal histoplasmosis simulating Crohn disease in a patient with hyperimmunoglobulin E syndrome. Pediatr Infect Dis J. 2009;28:744-6 pubmed publisher
    ..Histopathologic findings of the terminal ileum demonstrated intracellular yeast forms compatible with Histoplasma capsulatum. The patient was treated with oral itraconazole and had a rapid and complete response. ..
  4. Knox K, Hage C. Histoplasmosis. Proc Am Thorac Soc. 2010;7:169-72 pubmed publisher
    b>Histoplasmosis is the most prevalent endemic fungal infection in North America. The clinical spectrum ranges from asymptomatic, self-limited illness to a life-threatening progressive disseminated disease...
  5. Aidê M. Chapter 4--histoplasmosis. J Bras Pneumol. 2009;35:1145-51 pubmed
    b>Histoplasmosis is systemic mycosis caused by a small fungus, Histoplasma capsulatum var. capsulatum, whose natural habitat is soil contaminated by bat or bird excrement. The incidence of histoplasmosis is worldwide...
  6. Pochini Sobrinho F, Della Negra M, Queiroz W, José Ribeiro U, Bittencourt S, Burlamaqui Klautau G. Histoplasmosis of the larynx. Braz J Otorhinolaryngol. 2007;73:857-861 pubmed publisher
    The incidence of laryngeal histoplasmosis is low when compared to the total number of cases. Less than 100 cases of laryngeal histoplasmosis have been described in the medical literature...
  7. Edwards J, Alore E, Rappleye C. The yeast-phase virulence requirement for ?-glucan synthase differs among Histoplasma capsulatum chemotypes. Eukaryot Cell. 2011;10:87-97 pubmed publisher
    ..In a murine model of histoplasmosis, the ags1(-) chemotype I mutant strains show no defect in lung infection or in extrapulmonary dissemination...
  8. Julg B, Elias J, Zahn A, Köppen S, Becker Gaab C, Bogner J. Bat-associated histoplasmosis can be transmitted at entrances of bat caves and not only inside the caves. J Travel Med. 2008;15:133-6 pubmed publisher
    Our observation of histoplasmosis cases augments the current knowledge on transmission by bats. In the presented cases, the only contact happened in the proximity of a bat cave but not inside the cave...
  9. Myint T, Anderson A, Sanchez A, Farabi A, Hage C, Baddley J, et al. Histoplasmosis in patients with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS): multicenter study of outcomes and factors associated with relapse. Medicine (Baltimore). 2014;93:11-8 pubmed publisher
    ..discontinuation of suppressive antifungal therapy for acquired immunodeficiency syndrome (AIDS)-associated histoplasmosis is accepted for patients with immunologic recovery, there have been no published studies of this approach in ..

More Information

Publications79

  1. Arango M, Castaneda E, Agudelo C, de Bedout C, Agudelo C, Tobón A, et al. Histoplasmosis: results of the Colombian national survey, 1992-2008. Biomedica. 2011;31:344-56 pubmed publisher
    b>Histoplasmosis, a fungal disorder characterized by a wide spectrum of manifestations that range from subclinical infections to disseminated processes, affects both immunocompetent and immunosuppressed individuals...
  2. Mukhopadhyay S, Katzenstein A. Biopsy findings in acute pulmonary histoplasmosis: unusual histologic features in 4 cases mimicking lymphomatoid granulomatosis. Am J Surg Pathol. 2010;34:541-6 pubmed publisher
    Most examples of pulmonary histoplasmosis, including histoplasmoma and chronic histoplasmosis, are characterized by typical necrotizing granulomatous inflammation...
  3. Kadaria D, Archie D, SultanAli I, Weiman D, Freire A, Zaman M. Dual time point positron emission tomography/computed tomography scan in evaluation of intrathoracic lesions in an area endemic for histoplasmosis and with high prevalence of sarcoidosis. Am J Med Sci. 2013;346:358-62 pubmed publisher
    ..This could be a very helpful diagnostic finding in areas with high prevalence of benign conditions such as histoplasmosis and sarcoidosis...
  4. Kauffman C. Diagnosis of histoplasmosis in immunosuppressed patients. Curr Opin Infect Dis. 2008;21:421-5 pubmed publisher
    To define the most appropriate studies for making a diagnosis of histoplasmosis in immunosuppressed patients...
  5. Kauffman C. Histoplasmosis. Clin Chest Med. 2009;30:217-25, v pubmed publisher
    b>Histoplasmosis is the most common endemic mycosis causing human infection. Large outbreaks have been ascribed to histoplasmosis, but most infections are sporadic...
  6. Torres Rodríguez J, Segura Roca G, Coll J. [Histoplasmosis 45 years after infection in an immunocompetent man]. Rev Iberoam Micol. 2009;26:244-6 pubmed publisher
    We report a case of a lung reactivation of a latent histoplasmosis in a 68-year-old patient without immunologic dysfunction living in Barcelona (Spain). The Histoplasma capsulatum var...
  7. Medeiros A, Sa Nunes A, Turato W, Secatto A, Frantz F, Sorgi C, et al. Leukotrienes are potent adjuvant during fungal infection: effects on memory T cells. J Immunol. 2008;181:8544-51 pubmed
    ..capsulatum against histoplasmosis was associated with increased LTB(4) and IFN-gamma production as well as recruitment of memory T cells into ..
  8. Rana C, Krishnani N, Kumari N. Bilateral adrenal histoplasmosis in immunocompetent patients. Diagn Cytopathol. 2011;39:294-6 pubmed publisher
    b>Histoplasmosis is a fungal infection caused by Histoplasma capsulatum, which commonly presents as transient pulmonary infection that usually subsides without treatment...
  9. Dhawan J, Verma P, Sharma A, Ramam M, Kabra S, Gupta S. Disseminated cutaneous histoplasmosis in an immunocompetent child, relapsed with itraconazole, successfully treated with voriconazole. Pediatr Dermatol. 2010;27:549-51 pubmed publisher
    We present a rare case of disseminated cutaneous histoplasmosis in an immunocompetent child who relapsed after treatment with amphotericin B followed by itraconazole and was successfully treated with voriconazole.
  10. Golda N, Feldman M. Histoplasmosis clinically imitating cutaneous malignancy. J Cutan Pathol. 2008;35 Suppl 1:26-8 pubmed publisher
    Disseminated histoplasmosis can have a varied presentation when it affects the skin. Presentation mimicking a cutaneous neoplasm is an uncommon manifestation...
  11. Chalhoub E, Elhomsy G, Brake M. Hypercalcemia in histoplasmosis aggravated with antifungal treatment. J Med Liban. 2012;60:165-8 pubmed
    Hypercalcemia is a known, but rare complication of histoplasmosis, a granulomatous disease...
  12. Santos J, Michel G, Lazzarotto M, Figaro J, Spilmann D, Homrich G. Chronic cavitary pulmonary histoplasmosis. J Bras Pneumol. 2009;35:1161-4 pubmed
    b>Histoplasmosis is a systemic mycosis caused by the thermally dimorphic fungus Histoplasma capsulatum, which can be isolated from soil contaminated with droppings from birds or bats...
  13. Shersher D, Hong E, Breard J, Warren W, Liptay M. Anterior mediastinal mass secondary to histoplasmosis. Ann Thorac Surg. 2012;93:e9-10 pubmed publisher
    b>Histoplasmosis in the mediastinum is an uncommon diagnosis that presents similarly to other benign and neoplastic conditions encountered in the chest...
  14. Hilty J, Smulian A, Newman S. The Histoplasma capsulatum vacuolar ATPase is required for iron homeostasis, intracellular replication in macrophages and virulence in a murine model of histoplasmosis. Mol Microbiol. 2008;70:127-39 pubmed publisher
    ..The vma1::HPH mutant was avirulent in a mouse model of histoplasmosis, whereas the vma1/VMA1 strain was as pathogenic as WT yeasts...
  15. Hanf M, Adenis A, Couppie P, Carme B, Nacher M. HIV-associated histoplasmosis in French Guiana: recent infection or reactivation?. AIDS. 2010;24:1777-8 pubmed publisher
    In order to determine whether HIV-associated disseminated histoplasmosis was a recent infection or a reactivation, time series of first episodes of disseminated histoplasmosis were analyzed...
  16. Escher M, Kainikkara T, Grabner A, Ott G, Stange E, Herrlinger K. [Histoplasmosis: uncommon opportunistic infection in a patient with HIV infection]. Dtsch Med Wochenschr. 2012;137:260-4 pubmed publisher
    ..A 19-year-old HIV-positive man was admitted with fever of unknown origin and poor general condition. Antiretroviral therapy had been stopped by the patient eight months prior to admission...
  17. Lofgren S, Kirsch E, Maro V, Morrissey A, Msuya L, Kinabo G, et al. Histoplasmosis among hospitalized febrile patients in northern Tanzania. Trans R Soc Trop Med Hyg. 2012;106:504-7 pubmed publisher
    b>Histoplasmosis may be common in East Africa but the diagnosis is rarely confirmed. We report 9 (0.9%) cases of probable histoplasmosis retrospectively identified among 970 febrile inpatients studied in northern Tanzania...
  18. Webster R, Sil A. Conserved factors Ryp2 and Ryp3 control cell morphology and infectious spore formation in the fungal pathogen Histoplasma capsulatum. Proc Natl Acad Sci U S A. 2008;105:14573-8 pubmed publisher
    ..This regulatory function is strikingly similar to the role of the Aspergillus Velvet A protein family in spore development in response to light, with the notable distinction that the H. capsulatum circuit responds to temperature...
  19. Qian Q, Humayun H, Humayun Y, Sethi S. Granulomatous interstitial nephritis associated with disseminated histoplasmosis in an immunocompetent patient. Am J Kidney Dis. 2011;58:1018-21 pubmed publisher
    ..This report emphasizes the importance of diagnosing histoplasmosis early...
  20. Wobser R, Wilpert J, Kayser G, Walz G, Stubanus M. [Disseminated histoplasmosis with involvement of mediastinum and skin in an immunocompetent patient]. Dtsch Med Wochenschr. 2009;134:589-93 pubmed publisher
    ..A 29-years-old Brazilian woman was admitted to hospital because of progressive dyspnoea, shivering and fever. She reported a noticeable swelling at the right mandible and an ulcerative tumor at the side of the nose...
  21. Gorocica P, Taylor M, Alvarado Vásquez N, Perez Torres A, Lascurain R, Zenteno E. The interaction between Histoplasma capsulatum cell wall carbohydrates and host components: relevance in the immunomodulatory role of histoplasmosis. Mem Inst Oswaldo Cruz. 2009;104:492-6 pubmed
    ..capsulatum and host carbohydrate-driven interactions that allow for binding and internalization of the fungal cell into phagocytes and its subsequent avoidance of intracellular elimination...
  22. Kamili Q, Menter A. Atypical presentation of histoplasmosis in a patient with psoriasis and psoriatic arthritis on infliximab therapy. J Drugs Dermatol. 2010;9:57-60 pubmed
    ..The authors report a case of histoplasmosis presenting with signs of severe hypercalcemia and renal failure in a patient on infliximab for approximately ..
  23. Sanmani L, Randall C, Palfrey J, Rowen D. Hoarseness of voice in an AIDS patient: a rare presenting feature of disseminated histoplasmosis. Int J STD AIDS. 2011;22:115-6 pubmed publisher
    Laryngeal histoplasmosis is very rare among patients with HIV and very few cases have so far been documented...
  24. Ferreira M, Borges A. [Histoplasmosis]. Rev Soc Bras Med Trop. 2009;42:192-8 pubmed
    b>Histoplasmosis is a fungal infection caused by the dimorphic fungus Histoplasma capsulatum. It is classically considered an endemic mycosis, even though the fungus has an opportunistic behavior in immunocompromised patients...
  25. Zöllner M, Rezende K, Birman S, Elias C, Arisawa E, Santos M. Clinical and evolutionary characteristics of four patients with pulmonary histoplasmosis reported in the Paraíba Paulista Valley region. Rev Soc Bras Med Trop. 2010;43:599-601 pubmed
    The type of pulmonary histoplasmosis presents limited lesions to the lungs, with symptoms that are clinically and radiological similar to chronic pulmonary tuberculosis...
  26. Martinez L, Mihu M, Gacser A, Santambrogio L, Nosanchuk J. Methamphetamine enhances histoplasmosis by immunosuppression of the host. J Infect Dis. 2009;200:131-41 pubmed publisher
    ..We showed that methamphetamine abrogates normal macrophage function, resulting in an inability to control histoplasmosis. Methamphetamine decreased phagocytosis and killing of yeast by primary macrophages by alkalization of the ..
  27. Schadlu R, Blinder K, Shah G, Holekamp N, Thomas M, Grand M, et al. Intravitreal bevacizumab for choroidal neovascularization in ocular histoplasmosis. Am J Ophthalmol. 2008;145:875-8 pubmed publisher
    To define the role of intravitreal bevacizumab in individuals with choroidal neovascularization (CNV) resulting from Ocular Histoplasmosis syndrome (OHS).
  28. Mata Essayag S, Colella M, Roselló A, de Capriles C, Landaeta M, de Salazar C, et al. Histoplasmosis: a study of 158 cases in Venezuela, 2000-2005. Medicine (Baltimore). 2008;87:193-202 pubmed publisher
    b>Histoplasmosis, a granulomatous disease caused by Histoplasma capsulatum, is endemic in Venezuela...
  29. Hage C, Wheat L, Loyd J, Allen S, Blue D, Knox K. Pulmonary histoplasmosis. Semin Respir Crit Care Med. 2008;29:151-65 pubmed publisher
    Pulmonary manifestations of histoplasmosis were last reviewed in Seminars in 2004. This review highlights the management of the most common clinical syndromes, emphasizing recognition, diagnosis, and treatment...
  30. Threlkeld Z, Broughton R, Khan G, Berger J. Isolated Histoplasma capsulatum meningoencephalitis in an immunocompetent child. J Child Neurol. 2012;27:532-5 pubmed publisher
    b>Histoplasmosis with central nervous system involvement typically arises in the immunocompromised patient with disseminated fungal disease...
  31. Deepe G, Gibbons R. TNF-alpha antagonism generates a population of antigen-specific CD4+CD25+ T cells that inhibit protective immunity in murine histoplasmosis. J Immunol. 2008;180:1088-97 pubmed
    ..with TNF-alpha antagonists is associated with serious infectious complications including disseminated histoplasmosis. The mechanisms by which inhibition of endogenous TNF-alpha alter protective immunity remain obscure...
  32. McKinsey D, McKinsey J, Northcutt N, Sarria J. Interlaboratory discrepancy of antigenuria results in 2 patients with AIDS and histoplasmosis. Diagn Microbiol Infect Dis. 2009;63:111-4 pubmed publisher
    Histoplasma polysaccharide antigen testing is used routinely to diagnose histoplasmosis. At least 3 antigen tests are commercially available. Controversy exists about the relative accuracy of these tests...
  33. de Lavaissiere M, Manceron V, Bouree P, Garcon L, Bisaro F, Delfraissy J, et al. Reconstitution inflammatory syndrome related to histoplasmosis, with a hemophagocytic syndrome in HIV infection. J Infect. 2009;58:245-7 pubmed publisher
    ..The immune reconstitution inflammatory syndrome might be a risk factor for hemophagocytosis...
  34. Hage C, Bowyer S, Tarvin S, Helper D, Kleiman M, Wheat L. Recognition, diagnosis, and treatment of histoplasmosis complicating tumor necrosis factor blocker therapy. Clin Infect Dis. 2010;50:85-92 pubmed publisher
    Life-threatening histoplasmosis is one of the most common opportunistic infections in patients receiving tumor necrosis factor (TNF) blockers. Delays in considering the diagnosis may lead to increased morbidity and mortality...
  35. Nacher M, Adenis A, Aznar C, Blanchet D, Vantilcke V, Demar M, et al. How many have died from undiagnosed human immunodeficiency virus-associated histoplasmosis, a treatable disease? Time to act. Am J Trop Med Hyg. 2014;90:193-4 pubmed publisher
    ..the available incidence data and the regional HIV prevalence, it is expected that, every year, 1,500 cases of histoplasmosis affect HIV patients in that region alone...
  36. Mandengue C, Lindou J, Mandeng N, Takuefou B, Nouedoui C, Atangana P, et al. [Fatal miliary tuberculosis in an HIV-infected Cameroon woman: disseminated histoplasmosis due to Histoplasma capsulatum capsulatum]. Med Trop (Mars). 2011;71:615-7 pubmed
    The purpose of this report is to describe the first Cameroonian case of disseminated histoplasmosis due to Histoplasma capsulatum capsulatum in association with HIV infection. The patient was a 34-year-old HIV1 infected woman...
  37. Hsieh S, Lin J, Huang J, Wu S, Chu C, Kung J, et al. Immunization with apoptotic phagocytes containing Histoplasma capsulatum activates functional CD8(+) T cells to protect against histoplasmosis. Infect Immun. 2011;79:4493-502 pubmed publisher
    ..These results suggest that employing apoptotic phagocytes as antigen donor cells is a viable approach for the development of efficacious vaccines to elicit strong CD8(+) T cell as well as CD4(+) T cell responses to Histoplasma infection...
  38. Andrade R, Evans R, Hamill R, Zerai T, Giordano T. Clinical evidence of interaction between itraconazole and nonnucleoside reverse transcriptase inhibitors in HIV-infected patients with disseminated histoplasmosis. Ann Pharmacother. 2009;43:908-13 pubmed publisher
    Itraconazole is the preferred drug for chronic maintenance therapy in HIV-infected patients with disseminated histoplasmosis. Unfortunately, few clinical data exist confirming a presumed interaction between itraconazole and nonnucleoside ..
  39. Hage C, Kirsch E, Stump T, Kauffman C, Goldman M, Connolly P, et al. Histoplasma antigen clearance during treatment of histoplasmosis in patients with AIDS determined by a quantitative antigen enzyme immunoassay. Clin Vaccine Immunol. 2011;18:661-6 pubmed publisher
    ..Clearance of Histoplasma antigen has been used as a marker for response to treatment of progressive disseminated histoplasmosis (PDH) in patients with AIDS...
  40. Aisenberg G, Marcos L, Ogbaa I. Recurrent histoplasmosis in AIDS mimicking a colonic carcinoma. Int J STD AIDS. 2009;20:429-30 pubmed publisher
    ..6%. A 42-year-old woman with AIDS (CD(4) count 9/microL) and recently treated for disseminated histoplasmosis presented to the emergency room with melena, severe anaemia and fever...
  41. Cao C, Bulmer G, Li J, Liang L, Lin Y, Xu Y, et al. Indigenous case of disseminated histoplasmosis from the Penicillium marneffei endemic area of China. Mycopathologia. 2010;170:47-50 pubmed publisher
    This is the first indigenous case of disseminated histoplasmosis reported from the Penicillium marneffei endemic area in southern China...
  42. Oikawa F, Carvalho D, Matsuda N, Yamada A. Histoplasmosis in the nasal septum without pulmonary involvement in a patient with acquired immunodeficiency syndrome: case report and literature review. Sao Paulo Med J. 2010;128:236-8 pubmed
    b>Histoplasmosis is a fungal disease caused by inhaling spores of the fungus Histoplasma capsulatum. The spores can be found in soil contaminated with bird, bat or chicken feces...
  43. Bhagwat P, Hanumanthayya K, Tophakhane R, Rathod R. Two unusual cases of histoplasmosis in human immunodeficiency virus-infected individuals. Indian J Dermatol Venereol Leprol. 2009;75:173-6 pubmed
    b>Histoplasmosis, also called as Darling's disease, is caused by the dimorphic fungus, Histoplasma capsulatum...
  44. Hage C, Davis T, Fuller D, Egan L, Witt J, Wheat L, et al. Diagnosis of histoplasmosis by antigen detection in BAL fluid. Chest. 2010;137:623-8 pubmed publisher
    Detection of antigen in BAL is useful for diagnosis of histoplasmosis. The MVista Histoplasma antigen enzyme immunoassay has been modified to permit quantification...
  45. Goldani L, Aquino V, Lunardi L, Cunha V, Santos R. Two specific strains of Histoplasma capsulatum causing mucocutaneous manifestations of histoplasmosis: preliminary analysis of a frequent manifestation of histoplasmosis in southern Brazil. Mycopathologia. 2009;167:181-6 pubmed publisher
    ..It is possible that genetic differences among strains of H. capsulatum may influence the pathogenesis and clinical manifestations of histoplasmosis.
  46. Qualtieri J, Stratton C, Head D, Tang Y. PCR detection of Histoplasma capsulatum var. capsulatum in whole blood of a renal transplant patient with disseminated histoplasmosis. Ann Clin Lab Sci. 2009;39:409-12 pubmed
    ..capsulatum from whole blood in a renal transplant patient with disseminated histoplasmosis using colorimetric microtiter-plate PCR...
  47. Ehrlich R, Ciulla T, Maturi R, Kheradiya N, Hrisomalos N, Shulman S, et al. Intravitreal bevacizumab for choroidal neovascularization secondary to presumed ocular histoplasmosis syndrome. Retina. 2009;29:1418-23 pubmed publisher
    The purpose of this study was to assess the efficacy of intravitreal bevacizumab for choroidal neovascularization resulting from presumed ocular histoplasmosis syndrome.
  48. Teoh J, Hassan F, Mohamad Yunus M. Laryngeal histoplasmosis: an occupational hazard. Singapore Med J. 2013;54:e208-10 pubmed
    Isolated laryngeal histoplasmosis is a very rare entity. It has variable clinical presentations that might mimic both benign and malignant lesions, and is usually associated with pulmonary and other disseminated forms of histoplasmosis...
  49. Lopes L, Guimaraes A, de Cerqueira M, Gomez B, Nosanchuk J. A histoplasma capsulatum-specific IgG1 isotype monoclonal antibody, H1C, to a 70-kilodalton cell surface protein is not protective in murine histoplasmosis. Clin Vaccine Immunol. 2010;17:1155-8 pubmed publisher
    ..This further demonstrates the complexities of host-pathogen interactions...
  50. Naniwadekar A, Malhotra A. Education and imaging. Gastrointestinal: Gastrointestinal histoplasmosis. J Gastroenterol Hepatol. 2008;23:668 pubmed publisher
  51. Mehta V, De A, Balachandran C, Monga P. Mucocutaneous histoplasmosis in HIV with an atypical ecthyma like presentation. Dermatol Online J. 2009;15:10 pubmed
    Pulmonary and disseminated forms of histoplasmosis are very common in AIDS, but primary cutaneous histoplasmosis is rare. We report a case of primary mucocutaneous histoplasmosis in the setting of HIV.
  52. Peppa D, Plumb I, du Parcq J, Taylor S, Miller R. Gastrointestinal histoplasmosis in an HIV-infected patient living in a non-endemic area. Int J STD AIDS. 2008;19:864-5 pubmed publisher
    ..Biopsy of the duodenum and an intra-abdominal lymph node showed Histoplasma capsulatum. The diagnosis of histoplasmosis was delayed as the presentation was initially ascribed to intercurrent enteric pathogens and the patient's ..
  53. Kurai J, Konishi T, Hayabuchi T, Shimizu E. [Case of an HTLV-1 carrier complicated with chronic pulmonary histoplasmosis]. Nihon Kokyuki Gakkai Zasshi. 2008;46:737-42 pubmed
    ..At a later day, the histoplasma immunodiffusion test showed positive results. We finally diagnosed pulmonary histoplasmosis based on the clinical course, CT and radiographic images and serological tests...
  54. Viswanathan S, Chawla N, D cruz A, Kane S. Head and neck histoplasmosis--a nightmare for clinicians and pathologists! Experience at a tertiary referral cancer centre. Head Neck Pathol. 2007;1:169-72 pubmed publisher
    b>Histoplasmosis is a rarely reported deep mycotic infection in the Indian context...
  55. Pereira G, Pádua S, Park M, Muller R, Passos R, Menezes Y. Chronic meningitis by histoplasmosis: report of a child with acute myeloid leukemia. Braz J Infect Dis. 2008;12:555-7 pubmed
    Meningitis is a common evolution in progressive disseminated histoplasmosis in children, and is asymptomatic in many cases. In leukemia, the impaired of the T cells function can predispose to the disseminated form...
  56. Singh S, Kalra R, Chhabra S, Agarwal R, Garg S, Mathur S. Variable clinical presentations of histoplasmosis: a report of six cases. Trop Doct. 2012;42:32-4 pubmed publisher
    ..It has emerged as an important opportunistic fungal infection in immunocompromised patients. Six cases of histoplasmosis with variable clinical presentations diagnosed either on cytology or histopathology are discussed - three were ..
  57. Ge L, Zhou C, Song Z, Zhang Y, Wang L, Zhong B, et al. Primary localized histoplasmosis with lesions restricted to the mouth in a Chinese HIV-negative patient. Int J Infect Dis. 2010;14 Suppl 3:e325-8 pubmed publisher
    b>Histoplasmosis is a deep mycosis caused by Histoplasma capsulatum, which is endemic in many areas of the world but is relatively rare in China...
  58. Hage C, Ribes J, Wengenack N, Baddour L, Assi M, McKinsey D, et al. A multicenter evaluation of tests for diagnosis of histoplasmosis. Clin Infect Dis. 2011;53:448-54 pubmed publisher
    ..the MVista Histoplasma antigen enzyme immunoassay (MiraVista Diagnostics) has been evaluated in disseminated histoplasmosis in patients with AIDS and in the "epidemic" form of acute pneumonia...
  59. Smith J, Kauffman C. Endemic fungal infections in patients receiving tumour necrosis factor-alpha inhibitor therapy. Drugs. 2009;69:1403-15 pubmed publisher
  60. Pervez M, Cobb B, Matin N, Shahrin L, Ford E, Pietroni M. Disseminated histoplasmosis in a patient with advanced HIV disease--lessons learnt from Bangladesh. J Health Popul Nutr. 2010;28:305-7 pubmed
    b>Histoplasmosis is a systemic fungal disease, also known as Darling's disease, caused by the dimorphic fungus Histoplasma capsulatum...
  61. Deepe G, Gibbons R, Smulian A. Histoplasma capsulatum manifests preferential invasion of phagocytic subpopulations in murine lungs. J Leukoc Biol. 2008;84:669-78 pubmed publisher
    ..These results reveal the complex nature of intracellular residence of this fungus. Moreover, the findings demonstrate that there is a skewing in the subpopulations of cells that are infected, especially DC...
  62. Orsi A, Nogueira L, Chrusciak Talhari A, Santos M, Ferreira L, Talhari S, et al. Histoplasmosis and AIDS co-infection. An Bras Dermatol. 2011;86:1025-6 pubmed
    This report concerns an AIDS patient presenting systemic and cutaneous manifestations of histoplasmosis. A histopathological and mycological examination of the skin lesion confirmed the diagnosis...
  63. Antonello V, Zaltron V, Vial M, Oliveira F, Severo L. Oropharyngeal histoplasmosis: report of eleven cases and review of the literature. Rev Soc Bras Med Trop. 2011;44:26-9 pubmed
    b>Histoplasmosis is a systemic mycosis endemic in Brazil, especially in the State of Rio Grande do Sul, where Histoplasma capsulatum was isolated from the soil. H...
  64. Eloubeidi M, Luz L, Crowe D, Snowden C, Morgan D, Arnoletti P. Bilateral adrenal gland enlargement secondary to histoplasmosis mimicking adrenal metastases: diagnosis with EUS-guided FNA. Diagn Cytopathol. 2010;38:357-9 pubmed publisher
    While adrenal gland histoplasmosis has been previously diagnosed by fine needle aspiration utilizing the percutaneous approach, EUS-FNA has not been employed in the diagnosis of this infection affecting both adrenal glands...
  65. Starnes S, Reed M, Meyer C, Shipley R, Jazieh A, Pina E, et al. Can lung cancer screening by computed tomography be effective in areas with endemic histoplasmosis?. J Thorac Cardiovasc Surg. 2011;141:688-93 pubmed publisher
    ..The goal of the present study was to determine whether lung cancer screening could be done while minimizing the number of benign biopsy specimens taken in an area endemic for histoplasmosis.
  66. Espinosa Avilés D, Taylor M, del Rocio Reyes Montes M, Pérez Torrez A. Molecular findings of disseminated histoplasmosis in two captive snow leopards (Uncia uncia). J Zoo Wildl Med. 2008;39:450-4 pubmed
    This paper reports two cases of disseminated histoplasmosis in captive snow leopards (Uncia uncia). Histoplasmosis was diagnosed based on histopathology, immunohistochemistry, transmission electron microscopy, and molecular findings.
  67. Nosanchuk J, Gacser A. Histoplasma capsulatum at the host-pathogen interface. Microbes Infect. 2008;10:973-7 pubmed publisher
    ..immunomodulators in medicine has revealed significant risks for reactivation disease in patients with latent histoplasmosis. Fortunately, there are well developed molecular tools and excellent animal models for studying H...
  68. Bonifaz A, Vázquez González D, Perusquía Ortiz A. Endemic systemic mycoses: coccidioidomycosis, histoplasmosis, paracoccidioidomycosis and blastomycosis. J Dtsch Dermatol Ges. 2011;9:705-14; quiz 715 pubmed publisher
    ..Coccidioidomycosis is present in semi-desert areas, histoplasmosis and paracoccidioidomycosis in tropical regions and blastomycosis belongs to temperate climates...
  69. Buitrago M, Bernal Martinez L, Castelli M, Rodriguez Tudela J, Cuenca Estrella M. Histoplasmosis and paracoccidioidomycosis in a non-endemic area: a review of cases and diagnosis. J Travel Med. 2011;18:26-33 pubmed publisher
    b>Histoplasmosis and paracoccidioidomycosis (PCM) have increased in Spain in recent years, due firstly to the migration from endemic regions and secondly to travelers returning from these regions...
  70. Deepe G, Gibbons R. Interleukins 17 and 23 influence the host response to Histoplasma capsulatum. J Infect Dis. 2009;200:142-51 pubmed publisher
    ..Generation of functional IL-17(+) cells is dependent on IL-6 and IL-10. Our findings also establish the existence a regulatory IL-17/IL-23 axis in histoplasmosis.