amebic liver abscess


Summary: Single or multiple areas of PUS due to infection by any ameboid protozoa (AMEBIASIS). A common form is caused by the ingestion of ENTAMOEBA HISTOLYTICA.

Top Publications

  1. van Doorn H, Hofwegen H, Koelewijn R, Gilis H, Peek R, Wetsteyn J, et al. Use of rapid dipstick and latex agglutination tests and enzyme-linked immunosorbent assay for serodiagnosis of amebic liver abscess, amebic Colitis, and Entamoeba histolytica Cyst Passage. J Clin Microbiol. 2005;43:4801-6 pubmed
    ..with sera from 27 patients with radiologically proven, cellulose acetate precipitation (CAP) test-positive amebic liver abscess, 7 patients with parasitologically and PCR-proven amebic colitis, and 11 patients with parasitologically ..
  2. Wu K, Tsai H, Lee S, Liu Y, Wann S, Wang Y, et al. Comparison of clinical characteristics of amebic liver abscess in human immunodeficiency virus (HIV)-infected and non-HIV-infected patients. J Microbiol Immunol Infect. 2008;41:456-61 pubmed
    b>Amebic liver abscess is an emerging parasitic disease in human immunodeficiency virus (HIV)-infected patients. Clinical characteristics of this disease have rarely been compared between patients with and without HIV infection.
  3. Thammapalerd N, Sherchand J, Kotimanusvanij D, Chintana T, Tharavanij S. Monoclonal antibody-based ELISA for the detection of circulating Entamoeba histolytica antigen in hepatic amebiasis in hamsters (Mesocricetus auratus). Southeast Asian J Trop Med Public Health. 1996;27:760-4 pubmed
    ..Application of this test in amebic liver abscess patients should be of diagnostic value for indication of present infection or test of cure after successful ..
  4. Seydel K, Smith S, Stanley S. Innate immunity to amebic liver abscess is dependent on gamma interferon and nitric oxide in a murine model of disease. Infect Immun. 2000;68:400-2 pubmed
    ..disruption of the gene encoding inducible NO synthase to show that IFN-gamma plays a role in the innate immunity to amebic liver abscess seen in SCID mice while NO is required for control of amebic liver abscess in immunocompetent mice.
  5. Abd Alla M, Jackson T, Soong G, Mazanec M, Ravdin J. Identification of the Entamoeba histolytica galactose-inhibitable lectin epitopes recognized by human immunoglobulin A antibodies following cure of amebic liver abscess. Infect Immun. 2004;72:3974-80 pubmed
    ..The study subjects, from Durban, South Africa, were recently cured of amebic liver abscess (ALA) with or without concurrent Entamoeba histolytica intestinal infection or were infection free 1 year ..
  6. Simonishvili S, Tsanava S, Sanadze K, Chlikadze R, Miskalishvili A, Lomkatsi N, et al. Entamoeba histolytica: the serine-rich gene polymorphism-based genetic variability of clinical isolates from Georgia. Exp Parasitol. 2005;110:313-7 pubmed
    ..An outbreak of amebic liver abscess in Tbilisi, Georgia in 1998-1999 suggested that the causative E...
  7. Olivos Garcia A, Carrero J, Ramos E, Nequiz M, Tello E, Montfort I, et al. Late experimental amebic liver abscess in hamster is inhibited by cyclosporine and N-acetylcysteine. Exp Mol Pathol. 2007;82:310-5 pubmed
    During early experimental amebic liver abscess in hamsters (EALAH), acute inflammation is primarily responsible for tissue damage...
  8. Hsieh S, Chen M, Pan S, Hung C, Chang S. Aberrant induction of regulatory activity of CD4+CD25+ T cells by dendritic cells in HIV-infected persons with amebic liver abscess. J Acquir Immune Defic Syndr. 2007;44:6-13 pubmed
    To know why HIV-1-infected persons are particularly susceptible to amebic liver abscess (ALA), we investigated the role of CD4CD25 T cells in the susceptibility of HIV-1-infected persons to this disease...
  9. Pacheco Yepez J, Campos Rodríguez R, Shibayama M, Ventura Juárez J, Serrano Luna J, Tsutsumi V. Entamoeba histolytica: production of nitric oxide and in situ activity of NADPH diaphorase in amebic liver abscess of hamsters. Parasitol Res. 2001;87:49-56 pubmed
    ..levels [expressed as nitric oxide (NO) production] were determined at different times during amebic liver abscess (ALA) development...

More Information


  1. Short M, Desai A. Laparoscopy and transdiaphragmatic thoracoscopy in management of ruptured amebic liver abscess. J Laparoendosc Adv Surg Tech A. 2008;18:473-6 pubmed publisher
    In this paper, we present a case of an amebic liver abscess in a 30-month-old child, which presented to the senior author with a right empyema thoracic...
  2. Chen K, Yang C, Lin Y, Liu H, Liao S, Lee Y. Characteristics of amebic liver abscess in patients with or without human immunodeficiency virus. J Microbiol Immunol Infect. 2009;42:500-4 pubmed
    b>Amebic liver abscess (ALA) is the most common extra-intestinal amebiasis...
  3. Misra S, Misra V, Dwivedi M. Ileocecal masses in patients with amebic liver abscess: etiology and management. World J Gastroenterol. 2006;12:1933-6 pubmed
    To assess the causes of ileocecal mass in patients with amebic liver abscess.
  4. Hsu M, Hsieh S, Chen M, Hung C, Chang S. Association between amebic liver abscess and human immunodeficiency virus infection in Taiwanese subjects. BMC Infect Dis. 2008;8:48 pubmed publisher
    ..Thirty-three Taiwanese subjects with amebic liver abscess (ALA) were examined and a possible correlation between ALA and HIV infection was investigated.
  5. Lotter H, Rüssmann H, Heesemann J, Tannich E. Oral vaccination with recombinant Yersinia enterocolitica expressing hybrid type III proteins protects gerbils from amebic liver abscess. Infect Immun. 2004;72:7318-21 pubmed
    Protection against invasive amebiasis was achieved in the gerbil model for amebic liver abscess by oral immunization with live attenuated Yersinia enterocolitica expressing the Entamoeba histolytica galactose-inhibitable lectin that has ..
  6. Wiwanitkit V. A note on clinical presentations of amebic liver abscess: an overview from 62 Thai patients. BMC Fam Pract. 2002;3:13 pubmed
    b>Amebic liver abscess is a tropical disease with a wide spectrum of clinical presentations...
  7. Parija S, Khairnar K. Detection of excretory Entamoeba histolytica DNA in the urine, and detection of E. histolytica DNA and lectin antigen in the liver abscess pus for the diagnosis of amoebic liver abscess. BMC Microbiol. 2007;7:41 pubmed
    ..Here, we report for the first time the detection of E. histolytica DNA excreted in the urine for diagnosis of the cases of ALA...
  8. Stanley S, Zhang T, Rubin D, Li E. Role of the Entamoeba histolytica cysteine proteinase in amebic liver abscess formation in severe combined immunodeficient mice. Infect Immun. 1995;63:1587-90 pubmed
    ..Our study suggests an important role for a functional cysteine proteinase in amebic liver abscess formation.
  9. Ali I, Mondal U, Roy S, Haque R, Petri W, Clark C. Evidence for a link between parasite genotype and outcome of infection with Entamoeba histolytica. J Clin Microbiol. 2007;45:285-9 pubmed
    ..histolytica. The markers themselves do not indicate the nature of the underlying genetic differences, but they may be linked to loci that do have an impact on the outcome of infection...
  10. Torre A, Kershenobich D. Amebic liver abscess. Ann Hepatol. 2002;1:45-7 pubmed
    b>Amebic liver abscess (ALA) highly endemic in most developing tropical countries is being encountered more frequently in other geographical areas maybe secondary to increased travel to areas where the disease is endemic as well as in the ..
  11. Sandeep S, Banait V, Thakur S, Bapat M, Rathi P, Abraham P. Endoscopic biliary drainage in patients with amebic liver abscess and biliary communication. Indian J Gastroenterol. 2006;25:125-7 pubmed
    Percutaneous drainage or surgery is required when amebic liver abscess (ALA) fails to respond to medical management. In some of these patients, non-response may be due to communication of ALA with the biliary tree...
  12. Zhang X, Zhang Z, Alexander D, Bracha R, Mirelman D, Stanley S. Expression of amoebapores is required for full expression of Entamoeba histolytica virulence in amebic liver abscess but is not necessary for the induction of inflammation or tissue damage in amebic colitis. Infect Immun. 2004;72:678-83 pubmed
    ..we tested the virulence of amoebapore A(-) trophozoites in models of the two major forms of amebic disease: amebic liver abscess and amebic colitis...
  13. Calderaro A, Gorrini C, Bommezzadri S, Piccolo G, Dettori G, Chezzi C. Entamoeba histolytica and Entamoeba dispar: comparison of two PCR assays for diagnosis in a non-endemic setting. Trans R Soc Trop Med Hyg. 2006;100:450-7 pubmed
  14. Haque R, Kabir M, Noor Z, Rahman S, Mondal D, Alam F, et al. Diagnosis of amebic liver abscess and amebic colitis by detection of Entamoeba histolytica DNA in blood, urine, and saliva by a real-time PCR assay. J Clin Microbiol. 2010;48:2798-801 pubmed publisher
    The noninvasive diagnosis of amebic liver abscess is challenging, as most patients at the time of diagnosis do not have a concurrent intestinal infection with Entamoeba histolytica. Fecal testing for E...
  15. Blessmann J, Van Linh P, Nu P, Thi H, Muller Myhsok B, Buss H, et al. Epidemiology of amebiasis in a region of high incidence of amebic liver abscess in central Vietnam. Am J Trop Med Hyg. 2002;66:578-83 pubmed
    ..histolytica. In this regard, the distribution of amebic liver abscess (ALA) cases were analyzed in the province of Thua Thien Hué (TT Hué) in central Vietnam, a region known ..
  16. Lotter H, Jacobs T, Gaworski I, Tannich E. Sexual dimorphism in the control of amebic liver abscess in a mouse model of disease. Infect Immun. 2006;74:118-24 pubmed
    b>Amebic liver abscess (ALA) is the most common extraintestinal manifestation of human infection by the enteric protozoan parasite Entamoeba histolytica...
  17. Cheng X, Tachibana H. Protection of hamsters from amebic liver abscess formation by immunization with the 150- and 170-kDa surface antigens of Entamoeba histolytica. Parasitol Res. 2001;87:126-30 pubmed
    ..EH3015, prevents in vitro adherence of Entamoeba histolytica trophozoites to mammalian cells and inhibits amebic liver abscess formation in hamsters. By immunoaffinity chromatography with the monoclonal antibody, purified E...
  18. Yan L, Stanley S. Blockade of caspases inhibits amebic liver abscess formation in a mouse model of disease. Infect Immun. 2001;69:7911-4 pubmed
    We looked at the effect of inhibiting caspases on amebic liver abscess in the mouse model of infection...
  19. Khan U, Mirdha B, Samantaray J, Sharma M. Detection of Entamoeba histolytica using polymerase chain reaction in pus samples from amebic liver abscess. Indian J Gastroenterol. 2006;25:55-7 pubmed
    ..demonstration of Entamoeba histolytica by conventional microscopy and in vitro culture in pus obtained from amebic liver abscess (ALA) is often unsuccessful. We evaluated polymerase chain reaction (PCR) for detection of E...
  20. Park W, Choe P, Jo J, Kim S, Bang J, Kim H, et al. Amebic liver abscess in HIV-infected patients, Republic of Korea. Emerg Infect Dis. 2007;13:516-7 pubmed
  21. Hughes M, Petri W. Amebic liver abscess. Infect Dis Clin North Am. 2000;14:565-82, viii pubmed
    ..tract, but some patients may develop intestinal invasive disease or extraintestinal disease-amebic liver abscess being the most common extraintestinal manifestation...
  22. Wells C, Arguedas M. Amebic liver abscess. South Med J. 2004;97:673-82 pubmed
    b>Amebic liver abscess is the most common extraintestinal manifestation of infection with Entamoeba histolytica, and it is associated with significant morbidity and mortality...
  23. Muzaffar J, Madan K, Sharma M, Kar P. Randomized, single-blind, placebo-controlled multicenter trial to compare the efficacy and safety of metronidazole and satranidazole in patients with amebic liver abscess. Dig Dis Sci. 2006;51:2270-3 pubmed
    ..were to study the efficacy, side effects, and tolerance of metronidazole and satranidazole in patients of amebic liver abscess. Twenty-five patients received metronidazole (800 mg TID) and 24 received satranidazole (300 mg TID with ..
  24. Lotter H, González Roldán N, Lindner B, Winau F, Isibasi A, Moreno Lafont M, et al. Natural killer T cells activated by a lipopeptidophosphoglycan from Entamoeba histolytica are critically important to control amebic liver abscess. PLoS Pathog. 2009;5:e1000434 pubmed publisher
    The innate immune response is supposed to play an essential role in the control of amebic liver abscess (ALA), a severe form of invasive amoebiasis due to infection with the protozoan parasite Entamoeba histolytica...
  25. Zaman S, Khoo J, Ng S, Ahmed R, Khan M, Hussain R, et al. Direct amplification of Entamoeba histolytica DNA from amoebic liver abscess pus using polymerase chain reaction. Parasitol Res. 2000;86:724-8 pubmed
    ..Based on these results, we recommend that PCR assay can be successfully used to confirm the diagnosis of amoebic liver abscess with the primers identified...
  26. Sodhi K, Ojili V, Sakhuja V, Khandelwal N. Hepatic and inferior vena caval thrombosis: vascular complication of amebic liver abscess. J Emerg Med. 2008;34:155-7 pubmed
    Although amebic liver abscess is a common disease, it is a rare cause of venous thrombosis. Computed tomography (CT) scan is an ideal tool for diagnosing the various complications associated with liver abscess...
  27. Liu C, Hung C, Chen M, Lai Y, Chen P, Huang S, et al. Amebic liver abscess and human immunodeficiency virus infection: a report of three cases. J Clin Gastroenterol. 2001;33:64-8 pubmed
    ..We encountered a bisexual man with a protracted course of amebic liver abscess and amebic colitis...
  28. Hamzah Z, Petmitr S, Mungthin M, Leelayoova S, Chavalitshewinkoon Petmitr P. Differential detection of Entamoeba histolytica, Entamoeba dispar, and Entamoeba moshkovskii by a single-round PCR assay. J Clin Microbiol. 2006;44:3196-200 pubmed
  29. Valenzuela O, Moran P, Ramos F, Cardoza J, Garcia G, Valadez A, et al. Two different chitinase genotypes in a patient with an amebic liver abscess: a case report. Am J Trop Med Hyg. 2009;80:51-4 pubmed
    ..The present work deals with the identification of a patient with two liver abscesses containing two different strains of Entamoeba histolytica, as defined by chitinase gene plymorphisms...
  30. Tachibana H, Yanagi T, Akatsuka A, Kobayashi S, Kanbara H, Tsutsumi V. Isolation and characterization of a potentially virulent species Entamoeba nuttalli from captive Japanese macaques. Parasitology. 2009;136:1169-77 pubmed publisher
    ..These results demonstrate that the NASA6 strain is potentially virulent and that E. nuttalli should be recognized as a common parasite in macaques. ..
  31. Giménez Scherer J, Cardenas G, López Osuna M, Velazquez J, Rico G, Isibasi A, et al. Immunization with a tetramer derivative of an anti-inflammatory pentapeptide produced by Entamoeba histolytica protects gerbils (Meriones unguiculatus) against experimental amoebic abscess of the liver. Parasite Immunol. 2004;26:343-9 pubmed
    ..Invasive E. histolytica may produce the parent protein of MLIF in vivo, and if appropriately cleaved, it may play a role in invasive amoebiasis. MLIF may join new vaccination strategies against amoebiasis. ..
  32. Sanchez R, Saralegui A, Olivos Garcia A, Scapolla C, Damonte G, Sánchez López R, et al. Entamoeba histolytica: intracellular distribution of the sec61alpha subunit of the secretory pathway and down-regulation by antisense peptide nucleic acids. Exp Parasitol. 2005;109:241-51 pubmed
    ..The implications of these findings are discussed in the context of the peculiar cell biology of E. histolytica. ..
  33. Jeans A, McKendrick M. Salmonella Paratyphi A liver abscess--secondary infection of an amoebic liver abscess?. Travel Med Infect Dis. 2007;5:144-6 pubmed
    ..We present an unusual case of Salmonella Paratyphi A liver abscess, where secondary bacterial infection of an amoebic liver abscess was suspected...
  34. Abd Alla M, Jackson T, Rogers T, Reddy S, Ravdin J. Mucosal immunity to asymptomatic Entamoeba histolytica and Entamoeba dispar infection is associated with a peak intestinal anti-lectin immunoglobulin A antibody response. Infect Immun. 2006;74:3897-903 pubmed
    We monitored 93 subjects cured of amebic liver abscess (ALA) and 963 close associate controls in Durban, South Africa, and determined by enzyme-linked immunosorbent assay that the intestinal immunoglobulin A (IgA) antibody response to the ..
  35. Sadaka H, El Nassery S, Allam S, Eissa M, Baddour N. Experimental amoebic liver abcess produced by oral administration of Entamoeba histolytica cysts. J Egypt Soc Parasitol. 2001;31:407-17 pubmed
    ..Amoebic liver abscess was detected in 62.5% of them. Oral inoculation of E. histolytica cysts constitutes an easy highly reproducible procedure for inducing liver abscess in immunosuppressed mice. ..
  36. Wang W, Chadee K. Entamoeba histolytica alters arachidonic acid metabolism in macrophages in vitro and in vivo. Immunology. 1992;76:242-50 pubmed
  37. Tillack M, Nowak N, Lotter H, Bracha R, Mirelman D, Tannich E, et al. Increased expression of the major cysteine proteinases by stable episomal transfection underlines the important role of EhCP5 for the pathogenicity of Entamoeba histolytica. Mol Biochem Parasitol. 2006;149:58-64 pubmed
    ..In summary, these results further support the important role of EhCP5 in E. histolytica pathogenicity. ..
  38. Ramirez Emiliano J, Flores Villavicencio L, Segovia J, Arias Negrete S. [Nitric oxide participation during amoebic liver abscess development]. Medicina (B Aires). 2007;67:167-76 pubmed
    ..Therefore, it could be important to elucidate if, in humans, an excess in nitric oxide production favors amoebic liver abscess development. ..
  39. Zindrou S, Orozco E, Linder E, Tellez A, Bjorkman A. Specific detection of Entamoeba histolytica DNA by hemolysin gene targeted PCR. Acta Trop. 2001;78:117-25 pubmed
    ..PCR products were obtained only from specimens containing E. histolytica DNA. The haemo-PCR assay was therefore found to be a valuable diagnostic tool for identification of E. histolytica infections both in faeces and ALA samples. ..
  40. Kopterides P. Amebiasis. N Engl J Med. 2003;349:307-8; author reply 307-8 pubmed
  41. Kudara N, Oana S, Onodera K, Ishida W, Terui T, Endoh M, et al. [Amebic liver abscess with panperitonitis treated successfully with intravenous injection of metronidazole]. Nihon Naika Gakkai Zasshi. 2004;93:150-2 pubmed
  42. Tamura M, Ikeda T, Koyama T, Matsumoto T, Murakami T, Yamaoka K, et al. [A case of amebic liver abscess with anaphylactoid purpura]. Nihon Shokakibyo Gakkai Zasshi. 2002;99:1355-9 pubmed
  43. Knappik M, Borner U, Jelinek T. Sensitivity and specificity of a new commercial enzyme-linked immunoassay kit for detecting Entamoeba histolytica IgG antibodies in serum samples. Eur J Clin Microbiol Infect Dis. 2005;24:701-3 pubmed
    ..The assay was positive for 43 of 44 patients with invasive amebiasis, including all 18 patients with amebic liver abscess, while it was negative for 190 of 195 adult controls who were either healthy individuals or patients with ..
  44. Mohan S, Talwar N, Chaudhary A, Andley M, Ravi B, Kumar A. Liver abscess: a clinicopathological analysis of 82 cases. Int Surg. 2006;91:228-33 pubmed
    ..Ultrasound-guided needle aspiration and catheter drainage are safe and effective in the management of liver abscess. Drug therapy alone may be useful only in select cases. ..
  45. Botha U, Pilloy W, Strydom W. Importance of cholescintigraphy and inferior vena cava flow studies in the differential diagnosis of hepatocellular carcinoma. Am J Physiol Imaging. 1989;4:55-61 pubmed
    ..Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklear medizin. Erganzungsband 126:47-52 (1977). The results were compared with data previously collected in patients without liver disease (control) and other liver pathologies...
  46. McDermott C, Schur E. Shouldering a burden. Am J Med. 2008;121:13-5 pubmed publisher
  47. Samie A, Barrett L, Bessong P, Ramalivhana J, Mavhandu L, Njayou M, et al. Seroprevalence of Entamoeba histolytica in the context of HIV and AIDS: the case of Vhembe district, in South Africa's Limpopo province. Ann Trop Med Parasitol. 2010;104:55-63 pubmed publisher
    ..histolytica infection and HIV in South Africa. Further studies, for example to determine the occurrence of diarrhoea or liver abscess in the study area, in relation to seropositivity for E. histolytica and/or HIV, are now needed. ..
  48. Schwartz E, Piper Jenks N. Simultaneous amoebic liver abscess and hepatitis A infection. J Travel Med. 1998;5:95-6 pubmed
    ..It also challenges the assumption that jaundice in patients with amoebic liver abscess is due to amoebic hepatitis, rather than co-infection with viral hepatitis. ..
  49. Proctor E. Laboratory diagnosis of amebiasis. Clin Lab Med. 1991;11:829-59 pubmed
    ..New guidelines need to be formulated regarding the number of specimens to be submitted, and the cost effectiveness of various diagnostic procedures should be evaluated...
  50. Kannathasan S, Murugananthan A, Kumanan T, Iddawala D, de Silva N, Rajeshkannan N, et al. Amoebic liver abscess in northern Sri Lanka: first report of immunological and molecular confirmation of aetiology. Parasit Vectors. 2017;10:14 pubmed publisher
    ..To our knowledge, this is the first report from Sri Lanka that provides immunological and molecular confirmation that Entamoeba histolytica is a common cause of liver abscesses in the region. ..
  51. Pelosof L, Davis P, Zhang Z, Zhang X, Stanley S. Co-ordinate but disproportionate activation of apoptotic, regenerative and inflammatory pathways characterizes the liver response to acute amebic infection. Cell Microbiol. 2006;8:508-22 pubmed
    ..Focusing on early time points, we identified 764 genes with altered transcriptional levels in amebic liver abscess. The response to infection is rapid and complex, with concurrent increased expression of genes linked to ..
  52. Gutiérrez Alarcón A, Moguel Torres M, Mata Leyva O, Cuéllar Nevárez G, Siqueiros Cendón T, Erosa G, et al. Entamoeba histolytica: inflammatory process during amoebic liver abscess formation involves cyclooxygenase-2 expression in macrophages and trophozoites. Exp Parasitol. 2006;114:154-9 pubmed
    ..Additionally, a positive signal for COX-2 mRNA expression was detected in E. histolytica trophozoites, suggesting that, in vivo, parasite COX expression may be an important mechanism to promote inflammation. ..
  53. Singh M, Tiwari V, Jain A, Ghoshal S. Protective activity of picroliv on hepatic amoebiasis associated with carbon tetrachloride toxicity. Indian J Med Res. 2005;121:676-82 pubmed
    ..This study aims to evaluate the hepatoprotective action of picroliv against the hepatotoxic changes induced by carbon tetrachloride (CCl(4)) and E. histolytica infection in three animal models...
  54. Janbon F. [Travel in tropical countries. Advice before departure. Diseases upon return: fever, diarrhea]. Rev Prat. 2003;53:675-81 pubmed
  55. Nayeem M, Habibullah C. Correlation between membrane glycoprotein and detergent dissected membrane protein in the assessment of LMIF: a report of 51 ALA cases. Indian J Pathol Microbiol. 1993;36:260-4 pubmed
    ..These findings indicate that detergent dissected protein has similar antigenicity with membrane glycoprotein in elicitation cell mediated immune response in amoebic liver abscess cases...
  56. Velazquez C, Shibayama Salas M, Aguirre Garcia J, Tsutsumi V, Calderon J. Role of neutrophils in innate resistance to Entamoeba histolytica liver infection in mice. Parasite Immunol. 1998;20:255-62 pubmed
    ..In addition, our histological analysis suggests that E. histolytica is capable of producing liver damage in the absence of inflammatory cells...
  57. Stanley S, Reed S. Microbes and microbial toxins: paradigms for microbial-mucosal interactions. VI. Entamoeba histolytica: parasite-host interactions. Am J Physiol Gastrointest Liver Physiol. 2001;280:G1049-54 pubmed
    ..E. histolytica causes two major clinical syndromes, amebic colitis and amebic liver abscess. Recent advances in the development of in vitro and in vivo models of disease, new genetic approaches, the ..
  58. Read K, Kennedy Andrews S, Gordon D. Amoebic liver abscess in pregnancy. Aust N Z J Obstet Gynaecol. 2001;41:236-7 pubmed
    ..We present here the case of a caucasian female who presented with an amoebic liver abscess in the third trimester of pregnancy, thirteen months after returning to Australia from a short holiday in Bali...
  59. Balci N, Sirvanci M. MR imaging of infective liver lesions. Magn Reson Imaging Clin N Am. 2002;10:121-35, vii pubmed
    ..This article discusses MR imaging of infective liver lesions including pyogenic liver abscesses, amebic liver abscesses, echinococcal disease, hepatic fungal abscesses, granulomatous hepatic infections, schistosomiasis, and fascioliasis...
  60. Avendaño Arredondo A, Gil Galindo G, García Solís M, Pulido Rodrígue J. [Clinical experience of early percutaneous drainage of amebic hepatic abscess]. Cir Cir. 2007;75:157-62 pubmed
    ..We propose new indications for percutaneous drainage in this pathology. In our hospital we found a high incidence in laparotomies, morbidity and lengthy hospitalization for this illness...
  61. Miyauchi T, Takiya H, Sawamura T, Murakami E. Cardiac tamponade due to intrapericardial rupture of an amebic liver abscess. Jpn J Thorac Cardiovasc Surg. 2005;53:206-9 pubmed
    ..We report a case of pericardial abscess and cardiac tamponade due to intrapericardial rupture of an amebic liver abscess. A 31-year old Japanese male complained of fever to a local hospital...
  62. Marsik L, Ferko A, Vacek Z. [Amoebic liver abscess--case report]. Rozhl Chir. 2005;84:369-72 pubmed
    ..Open surgical tretment was indicated due to failure of percutaneous treatment. Patient was discharged home in a good condition one month after surgery. At this time patient is doing well eight months after surgery...
  63. Rachid H, Alaoui Yazidi A, Loudadssi F, El Biaze M, Bakhatar A, Yassine N, et al. [Amoebic infections of the lung and pleura]. Rev Mal Respir. 2005;22:1035-7 pubmed
    ..Pleuropulmonary involvement is the second most common extra-intestinal manifestation of entamoeba histolytica infection after liver abscess...
  64. Ivory C, Keller K, Chadee K. CpG-oligodeoxynucleotide is a potent adjuvant with an Entamoeba histolytica Gal-inhibitable lectin vaccine against amoebic liver abscess in gerbils. Infect Immun. 2006;74:528-36 pubmed
    ..This is the first report of the use of CpG as a potent Th1 adjuvant with Gal-lectin to increase protection against ALA formation...
  65. Díaz Gonzálvez E, Manzanedo Terán B, Lopez Velez R, Dronda F. [Liver abscess due to a native amoeba: a clinical case study and literature review]. Enferm Infecc Microbiol Clin. 2005;23:179-81 pubmed
  66. Valenzuela O, Moran P, Gomez A, Cordova K, Corrales N, Cardoza J, et al. Epidemiology of amoebic liver abscess in Mexico: the case of Sonora. Ann Trop Med Parasitol. 2007;101:533-8 pubmed
  67. Olivos Garcia A, Néquiz Avendaño M, Tello E, Martinez R, González Canto A, López Vancell R, et al. Inflammation, complement, ischemia and amoebic survival in acute experimental amoebic liver abscesses in hamsters. Exp Mol Pathol. 2004;77:66-71 pubmed
    ..We conclude that inflammation and tissue damage are required for the survival of amoebae in AEALAH and for the progression of the experimental disease...
  68. Pacheco J, Shibayama M, Campos R, Beck D, Houpt E, Petri W, et al. In vitro and in vivo interaction of Entamoeba histolytica Gal/GalNAc lectin with various target cells: an immunocytochemical analysis. Parasitol Int. 2004;53:35-47 pubmed
    ..The contribution of lectin transfer to host cells in adherence and cell injury remains to be determined...
  69. Graillet R, Sanchez Aguilar M, Morán Mendoza A, Hernández Sierra J, Gordillo Moscoso A, Tapia Perez J. [Analysis of factors associated to failure of medical treatment of amoebic liver abscess]. Cir Esp. 2008;84:83-6 pubmed
    ..To identify the laboratory and ultrasound factors that could predict the response to medical treatment of amoebic liver abscess...
  70. Ritchie J, Harper A, Malykh V, Rowland J. Amoebic liver abscess imitating metastatic caecal carcinoma. Age Ageing. 2005;34:527-8 pubmed
    ..This case discusses a patient whose initial investigations suggested an incurable carcinoma with a poor prognosis, but which later transpired to be an unusual but treatable infection...
  71. Arellano J, Perez Rodriguez M, López Osuna M, Velazquez J, Granados J, Justiniani N, et al. Increased frequency of HLA-DR3 and complotype SCO1 in Mexican mestizo children with amoebic abscess of the liver. Parasite Immunol. 1996;18:491-8 pubmed
    ..HLA-DR3, SCO1, but also HLA-DR5 and HLA-DR6 have all been associated with certain forms of immune-dysfunction, and may thus contribute to some of the clinical and immunological features of this parasitic disease...
  72. Kurland J, Brann O. Pyogenic and amebic liver abscesses. Curr Gastroenterol Rep. 2004;6:273-9 pubmed
    ..b>Amebic liver abscess is more prevalent in individuals with suppressed cell-mediated immunity, men, and younger people...
  73. Sengupta K, Ghosh P, Ganguly S, Das P, Maitra T, Jalan K. Characterization of entamoeba histolytica antigens in circulating immune complexes in sera of patients with amoebiasis. J Health Popul Nutr. 2002;20:215-22 pubmed
    ..The 35-kDa polypeptide was observed in 52 patients (81.25%). The results of the study suggest that the 35-kDa polypeptide antigen can be a diagnostic marker in active amoebiasis...
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    ..Awareness of this previously unreported association is important because it adds to our knowledge of the spectrum of intestinal amoebiasis...
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    ..histolytica, and possible bacterial superinfection should be evaluated...
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    The amebic liver abscess is uncommon in developed countries like Spain, but the incidence is increasing probably due to the migratory movements of the population...