soft tissue infections

Summary

Summary: Infections of non-skeletal tissue, i.e., exclusive of bone, ligaments, cartilage, and fibrous tissue. The concept is usually referred to as skin and soft tissue infections and usually subcutaneous and muscle tissue are involved. The predisposing factors in anaerobic infections are trauma, ischemia, and surgery. The organisms often derive from the fecal or oral flora, particularly in wounds associated with intestinal surgery, decubitus ulcer, and human bites. (From Cecil Textbook of Medicine, 19th ed, p1688)

Top Publications

  1. Mesrati I, Saïdani M, Ennigrou S, Zouari B, Ben Redjeb S. Clinical isolates of Pantone-Valentine leucocidin- and gamma-haemolysin-producing Staphylococcus aureus: prevalence and association with clinical infections. J Hosp Infect. 2010;75:265-8 pubmed
    ..6%) were community-acquired. There was a strong association between pvl genes and skin and soft tissue infections, especially abscesses (60% of strains; P = 0.008) and furunculosis (55.5% of strains; P = 0.036)...
  2. Landrum M, Neumann C, Cook C, Chukwuma U, Ellis M, Hospenthal D, et al. Epidemiology of Staphylococcus aureus blood and skin and soft tissue infections in the US military health system, 2005-2010. JAMA. 2012;308:50-9 pubmed publisher
    ..Rates of hospital-onset methicillin-resistant Staphylococcus aureus (MRSA) infections are reported as decreasing, but recent rates of community-onset S. aureus infections are less known...
  3. Fritz S, Hogan P, Hayek G, Eisenstein K, Rodriguez M, Epplin E, et al. Household versus individual approaches to eradication of community-associated Staphylococcus aureus in children: a randomized trial. Clin Infect Dis. 2012;54:743-51 pubmed publisher
    ..Community-associated Staphylococcus aureus infections often affect multiple members of a household. We compared 2 approaches to S. aureus eradication: decolonizing the entire household versus decolonizing the index case alone...
  4. Williams D, Cooper W, Kaltenbach L, Dudley J, Kirschke D, Jones T, et al. Comparative effectiveness of antibiotic treatment strategies for pediatric skin and soft-tissue infections. Pediatrics. 2011;128:e479-87 pubmed publisher
    ..To compare the effectiveness of clindamycin, trimethoprim-sulfamethoxazole, and ?-lactams for the treatment of pediatric skin and soft-tissue infections (SSTIs)...
  5. Kobayashi S, Malachowa N, Whitney A, Braughton K, Gardner D, Long D, et al. Comparative analysis of USA300 virulence determinants in a rabbit model of skin and soft tissue infection. J Infect Dis. 2011;204:937-41 pubmed publisher
    ..The data indicate that Hla, PSM?, and Agr contribute to the pathogenesis of USA300 skin infections in rabbits, whereas a role for PVL could not be detected...
  6. Lin J, Chang L, Lai C, Lin H, Chen Y. Clinical and molecular characteristics of invasive and noninvasive skin and soft tissue infections caused by group A Streptococcus. J Clin Microbiol. 2011;49:3632-7 pubmed publisher
    The severity of skin and soft tissue infections caused by group A Streptococcus (GAS) is variable, and there are only a limited number of studies evaluating the characteristics of these infections in the literature...
  7. Aikawa N, Kusachi S, Mikamo H, Takesue Y, Watanabe S, Tanaka Y, et al. Efficacy and safety of intravenous daptomycin in Japanese patients with skin and soft tissue infections. J Infect Chemother. 2013;19:447-55 pubmed publisher
    ..This study investigates the efficacy and safety of daptomycin in Japanese patients with skin and soft tissue infections (SSTIs) caused by methicillin-resistant Staphylococcus aureus (MRSA) for regulatory filing in Japan...
  8. Garau J, Ostermann H, Medina J, Avila M, McBride K, Blasi F. Current management of patients hospitalized with complicated skin and soft tissue infections across Europe (2010-2011): assessment of clinical practice patterns and real-life effectiveness of antibiotics from the REACH study. Clin Microbiol Infect. 2013;19:E377-85 pubmed publisher
    Complicated skin and soft tissue infections (cSSTI) are common and frequently require treatment in hospital. Comprehensive current data on management practices in patients hospitalized with cSSTI are limited...
  9. Sanchini A, Spitoni M, Monaco M, Raglio A, Grigis A, Petro W, et al. Outbreak of skin and soft tissue infections in a hospital newborn nursery in Italy due to community-acquired meticillin-resistant Staphylococcus aureus USA300 clone. J Hosp Infect. 2013;83:36-40 pubmed publisher
    ..Community-acquired meticillin-resistant Staphylococcus aureus (CA-MRSA) is responsible for severe infections in previously healthy people acquired in the community in different areas of the world...

More Information

Publications71

  1. Karamatsu M, Thorp A, Brown L. Changes in community-associated methicillin-resistant Staphylococcus aureus skin and soft tissue infections presenting to the pediatric emergency department: comparing 2003 to 2008. Pediatr Emerg Care. 2012;28:131-5 pubmed publisher
  2. Viswanathan K, Frey K, Scocchera E, Martin B, Swain Iii P, Alverson J, et al. Toward new therapeutics for skin and soft tissue infections: propargyl-linked antifolates are potent inhibitors of MRSA and Streptococcus pyogenes. PLoS ONE. 2012;7:e29434 pubmed publisher
    Hospital- and community-acquired, complicated skin and soft tissue infections, often attributed to Staphylococcus aureus and Streptococcus pyogenes, present a significant health burden that is associated with increased health care costs ..
  3. Walraven C, Lingenfelter E, Rollo J, Madsen T, Alexander D. Diagnostic and therapeutic evaluation of community-acquired methicillin-resistant Staphylococcus Aureus (MRSA) skin and soft tissue infections in the emergency department. J Emerg Med. 2012;42:392-9 pubmed publisher
    ..Emergency department (ED) pharmacists wished to provide specific data to emergency physicians to better inform antibiotic choices for patients with SSTIs...
  4. Lamy B, Laurent F, Gallon O, Doucet Populaire F, Etienne J, Decousser J. Antibacterial resistance, genes encoding toxins and genetic background among Staphylococcus aureus isolated from community-acquired skin and soft tissue infections in France: a national prospective survey. Eur J Clin Microbiol Infect Dis. 2012;31:1279-84 pubmed publisher
    ..MRSA strains isolated from putative CA-SSTIs exhibited a genetic and phenotypic background of hospital-acquired (HA) clones. National survey should be continued, in order to monitor the emergence of virulent clones...
  5. Soong G, Chun J, Parker D, Prince A. Staphylococcus aureus activation of caspase 1/calpain signaling mediates invasion through human keratinocytes. J Infect Dis. 2012;205:1571-9 pubmed publisher
    ..These studies suggest that pharmacological interruption of specific keratinocyte signaling cascades as well as targeting the Hla might prevent invasive skin infection by staphylococci...
  6. Barberán J, Farinas M. [Daptomycin in complicated skin and soft tissue infections]. Enferm Infecc Microbiol Clin. 2012;30 Suppl 1:33-7 pubmed publisher
    In recent years, Staphylococcus aureus, the most commonly identified infectious agent causing skin and soft tissue infections (SSTIs), has shown an increase in methicillin resistance and decreased susceptibility to vancomycin...
  7. Ray G, Suaya J, Baxter R. Microbiology of skin and soft tissue infections in the age of community-acquired methicillin-resistant Staphylococcus aureus. Diagn Microbiol Infect Dis. 2013;76:24-30 pubmed publisher
    ..In SSTI episodes with a culture-confirmed pathogen, MRSA increased from 5% in 1998 to 9% in 2001 to 42% in 2005, decreasing to 37% in 2009. These data can inform the choice of antibiotics for treatment of SSTIs...
  8. Hota B, Lyles R, Rim J, Popovich K, Rice T, Aroutcheva A, et al. Predictors of clinical virulence in community-onset methicillin-resistant Staphylococcus aureus infections: the importance of USA300 and pneumonia. Clin Infect Dis. 2011;53:757-65 pubmed publisher
    ..We sought to evaluate if the USA300 strain of CO-MRSA causes more severe infections than other MRSA (ie, USA100, -500, -800, and others) strains...
  9. Daly J, Levy B, Ely J, Swanson K, Bergus G, Jogerst G, et al. Management of skin and soft tissue infections in community practice before and after implementing a "best practice" approach: an Iowa Research Network (IRENE) intervention study. J Am Board Fam Med. 2011;24:524-33 pubmed publisher
    Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) is a major pathogen among skin and soft tissue infections (SSTIs). Most CA-MRSA infections are managed initially on an outpatient basis...
  10. Williamson D, Ritchie S, Lennon D, Roberts S, Stewart J, Thomas M, et al. Increasing incidence and sociodemographic variation in community-onset Staphylococcus aureus skin and soft tissue infections in New Zealand children. Pediatr Infect Dis J. 2013;32:923-5 pubmed publisher
    ..A total of 1860 children were included. There was significant sociodemographic disparity, with the incidence disproportionately higher in Maori and Pacific Island children residing in deprived areas. ..
  11. Covington P, Davenport J, Andrae D, O Riordan W, Liverman L, McIntyre G, et al. Randomized, double-blind, phase II, multicenter study evaluating the safety/tolerability and efficacy of JNJ-Q2, a novel fluoroquinolone, compared with linezolid for treatment of acute bacterial skin and skin structure infection. Antimicrob Agents Chemother. 2011;55:5790-7 pubmed publisher
    ..e., lack of spread of lesions and absence of fever at 48 to 72 h), and (ii) cure rates for ABSSSI pathogens (especially MRSA) consistent with the historical literature...
  12. Kish T, Chang M, Fung H. Treatment of skin and soft tissue infections in the elderly: A review. Am J Geriatr Pharmacother. 2010;8:485-513 pubmed publisher
    Skin and soft tissue infections (SSTIs) have become the second most common type of infection among persons residing in long-term care facilities.
  13. Zervos M, Freeman K, Vo L, Haque N, Pokharna H, Raut M, et al. Epidemiology and outcomes of complicated skin and soft tissue infections in hospitalized patients. J Clin Microbiol. 2012;50:238-45 pubmed publisher
    Complicated skin and soft tissue infections (cSSTIs) are among the most rapidly increasing reasons for hospitalization...
  14. Carman M, Phipps J, Raley J, Li S, Thornlow D. Use of a Clinical Decision Support Tool to improve guideline adherence for the treatment of methicillin-resistant Staphylococcus aureus: Skin and Soft Tissue Infections. Adv Emerg Nurs J. 2011;33:252-66 pubmed publisher
    Skin and Soft Tissue Infections (SSTI's) with abscess are commonly seen in the Emergency Department (ED) setting...
  15. Morgan M. Treatment of MRSA soft tissue infections: an overview. Injury. 2011;42 Suppl 5:S11-7 pubmed publisher
    ..emergence of new highly spreadable strains (community associated or CA-MRSA) novel presentation skin and soft tissue infections (SSTI) are being seen...
  16. May L, Porter C, Tribble D, Armstrong A, Mostafa M, Riddle M. Self-reported incidence of skin and soft tissue infections among deployed US military. Travel Med Infect Dis. 2011;9:213-20 pubmed publisher
    The incidence of skin and soft tissue infections has steadily increased over the past decade, and military populations, particularly recruits, have been affected...
  17. Truong H, Shah S, Ludmir J, Twananana E, Bafana M, Wood S, et al. Staphylococcus aureus skin and soft tissue infections at a tertiary hospital in Botswana. S Afr Med J. 2011;101:413-6 pubmed
    ..aureus isolates over time...
  18. Wilson J, Guy R, Elgohari S, Sheridan E, Davies J, Lamagni T, et al. Trends in sources of meticillin-resistant Staphylococcus aureus (MRSA) bacteraemia: data from the national mandatory surveillance of MRSA bacteraemia in England, 2006-2009. J Hosp Infect. 2011;79:211-7 pubmed publisher
    ..These changes have occurred in the context of a general decline in the rate of MRSA bacteraemia in England since 2006...
  19. Iverson K, Haritos D, Thomas R, Kannikeswaran N. The effect of bedside ultrasound on diagnosis and management of soft tissue infections in a pediatric ED. Am J Emerg Med. 2012;30:1347-51 pubmed publisher
    Presentation of skin and soft tissue infections (SSTIs) to the pediatric emergency department (PED) has increased. Physical examination alone can be inadequate in differentiating cellulitis from an abscess...
  20. Galloway J, Mercer L, Moseley A, Dixon W, Ustianowski A, Helbert M, et al. Risk of skin and soft tissue infections (including shingles) in patients exposed to anti-tumour necrosis factor therapy: results from the British Society for Rheumatology Biologics Register. Ann Rheum Dis. 2013;72:229-34 pubmed publisher
    ..In 2001, BSRBR was established to evaluate the safety of these agents. This paper addresses the safety of anti-TNF therapy in RA with specific reference to serious skin and soft tissue infections (SSSI) and shingles.
  21. Martinschek A, Evers B, Lampl L, Gerngroß H, Schmidt R, Sparwasser C. Prognostic aspects, survival rate, and predisposing risk factors in patients with Fournier's gangrene and necrotizing soft tissue infections: evaluation of clinical outcome of 55 patients. Urol Int. 2012;89:173-9 pubmed publisher
    To determine predisposing or prognostic factors and mortality rates of patients with Fournier's gangrene compared to other necrotizing soft tissue infections (NSTI).
  22. Rossini C, Moriarty K, Tashjian D, Garb J, Wait R. Geographic distribution of community-acquired methicillin-resistant Staphylococcus aureus soft tissue infections. J Pediatr Surg. 2011;46:1089-92 pubmed publisher
    ..The goal of this study is to look at the geographic growth patterns of community-acquired methicillin-resistant Staphylococcus aureus (MRSA) infections in our local region and to determine if specific geographic areas are at increased risk...
  23. Knox D, Murray G, Millar M, Hamilton D, Connor M, Ferdinand R, et al. Subcutaneous anthrax in three intravenous drug users: a new clinical diagnosis. J Bone Joint Surg Br. 2011;93:414-7 pubmed publisher
    ..We suggest that rather than cutaneous anthrax, these patients represent a new subcutaneous presentation of anthrax...
  24. McNeil J, Hulten K, Kaplan S, Mason E. Mupirocin resistance in Staphylococcus aureus causing recurrent skin and soft tissue infections in children. Antimicrob Agents Chemother. 2011;55:2431-3 pubmed publisher
    ..We tested S. aureus isolates from children at Texas Children's Hospital with recurrent skin and soft tissue infections for mupirocin resistance and mupA. Of 136 isolates, 20 were resistant to mupirocin (14.7%)...
  25. Itani K, Biswas P, Reisman A, Bhattacharyya H, Baruch A. Clinical efficacy of oral linezolid compared with intravenous vancomycin for the treatment of methicillin-resistant Staphylococcus aureus-complicated skin and soft tissue infections: a retrospective, propensity score-matched, case-control analysis. Clin Ther. 2012;34:1667-73.e1 pubmed publisher
    ..open-label, comparator-controlled, multicenter, phase 4 clinical trial in adults with complicated skin and soft tissue infections (cSSTIs) caused by methicillin-resistant Staphylococcus aureus (MRSA), linezolid achieved clinical and ..
  26. Marra F, Patrick D, Chong M, McKay R, Hoang L, Bowie W. Population-based study of the increased incidence of skin and soft tissue infections and associated antimicrobial use. Antimicrob Agents Chemother. 2012;56:6243-9 pubmed publisher
    ..Canada on physician visits, incision-and-drainage procedures, and antibiotic prescribing for skin and soft tissue infections (SSTI)...
  27. Shallcross L, Fragaszy E, Johnson A, Hayward A. The role of the Panton-Valentine leucocidin toxin in staphylococcal disease: a systematic review and meta-analysis. Lancet Infect Dis. 2013;13:43-54 pubmed publisher
    ..Whether PVL is pathogenic or an epidemiological marker is unclear. We investigate the role of PVL in disease, colonisation, and clinical outcome...
  28. Smith C, Goldman R. Staphylococcus aureus decolonization for recurrent skin and soft tissue infections in children. Can Fam Physician. 2012;58:1350-2 pubmed
    ..While I am comfortable with managing each acute infection, what can be done to eradicate Staphylococcus aureus and reduce the chance of recurrent infections?..
  29. Friederichs J, Hutter M, Hierholzer C, Novotny A, Friess H, Buhren V, et al. Procalcitonin ratio as a predictor of successful surgical treatment of severe necrotizing soft tissue infections. Am J Surg. 2013;206:368-73 pubmed publisher
    Necrotizing soft tissue infections often are characterized by fulminant presentation and lethal outcomes...
  30. Pate A, Terribilini R, Ghobadi F, Azhir A, Barber A, Pearson J, et al. Antibiotics for methicillin-resistant Staphylococcus aureus skin and soft tissue infections: the challenge of outpatient therapy. Am J Emerg Med. 2014;32:135-8 pubmed publisher
    ..Certain strains are notorious for causing skin and soft tissue infections in patients with no established risk factors...
  31. Myhrman E, Håkansson J, Lindgren K, Björn C, Sjöstrand V, Mahlapuu M. The novel antimicrobial peptide PXL150 in the local treatment of skin and soft tissue infections. Appl Microbiol Biotechnol. 2013;97:3085-96 pubmed publisher
    ..In conclusion, PXL150 may constitute a new therapeutic alternative for local treatment of infections, and further studies are warranted to evaluate the applicability of this AMP in clinical settings...
  32. Wang X, Towers S, Panchanathan S, Chowell G. A population based study of seasonality of skin and soft tissue infections: implications for the spread of CA-MRSA. PLoS ONE. 2013;8:e60872 pubmed publisher
    Methicillin resistant Staphylococcus aureus (MRSA) is currently a major cause of skin and soft tissue infections (SSTI) in the United States. Seasonal variation of MRSA infections in hospital settings has been widely observed...
  33. Konychev A, Heep M, Moritz R, Kreuter A, Shulutko A, Fierlbeck G, et al. Safety and efficacy of daptomycin as first-line treatment for complicated skin and soft tissue infections in elderly patients: an open-label, multicentre, randomized phase IIIb trial. Drugs Aging. 2013;30:829-36 pubmed publisher
    Daptomycin has proven efficacy in patients with Gram-positive complicated skin and soft tissue infections (cSSTIs), including those caused by Staphylococcus aureus, regardless of methicillin susceptibility.
  34. Fritz S, Camins B, Eisenstein K, Fritz J, Epplin E, Burnham C, et al. Effectiveness of measures to eradicate Staphylococcus aureus carriage in patients with community-associated skin and soft-tissue infections: a randomized trial. Infect Control Hosp Epidemiol. 2011;32:872-80 pubmed publisher
    ..Despite a paucity of evidence, decolonization measures are prescribed for outpatients with recurrent Staphylococcus aureus skin and soft-tissue infection (SSTI)...
  35. Mithoe D, Rijnders M, Roede B, Stobberingh E, Möller A. Prevalence of community-associated meticillin-resistant Staphylococcus aureus and Panton-Valentine leucocidin-positive S. aureus in general practice patients with skin and soft tissue infections in the northern and southern regions of The Netherlands. Eur J Clin Microbiol Infect Dis. 2012;31:349-56 pubmed publisher
    ..aureus in general practice (GP) patients with skin and soft tissue infections (SSTI) in the northern (Groningen and Drenthe) and southern (Limburg) regions of The Netherlands...
  36. Berger T, Garrido F, Green J, Lema P, Gupta J. Bedside ultrasound performed by novices for the detection of abscess in ED patients with soft tissue infections. Am J Emerg Med. 2012;30:1569-73 pubmed publisher
    ..The objective was to compare bedside ultrasound (US) to clinical examination for the detection of abscess...
  37. Forcade N, Parchman M, Jorgensen J, Du L, Nyren N, Treviño L, et al. Prevalence, severity, and treatment of community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) skin and soft tissue infections in 10 medical clinics in Texas: a South Texas Ambulatory Research Network (STARNet) study. J Am Board Fam Med. 2011;24:543-50 pubmed publisher
  38. Talan D, Krishnadasan A, Gorwitz R, Fosheim G, Limbago B, Albrecht V, et al. Comparison of Staphylococcus aureus from skin and soft-tissue infections in US emergency department patients, 2004 and 2008. Clin Infect Dis. 2011;53:144-9 pubmed publisher
    ..Little information exists regarding trends in MRSA prevalence and molecular characteristics or regarding antimicrobial susceptibility profiles of S. aureus isolates...
  39. Kaltsas A, Guh A, Mediavilla J, Varshney A, Robiou N, Gialanellia P, et al. Frequency of panton-valentine leukocidin-producing methicillin-sensitive Staphylococcus strains in patients with complicated skin and soft tissue infection in bronx, new york. J Clin Microbiol. 2011;49:2992-5 pubmed publisher
    ..aureus (MRSA) and MSSA SSTIs were comparable. In multivariable analysis, the presence of lukF-PV remained a significant predictor for incision and drainage among MSSA strains...
  40. Dalager Pedersen M, Søgaard M, Schønheyder H. Staphylococcus aureus skin and soft tissue infections in primary healthcare in Denmark: a 12-year population-based study. Eur J Clin Microbiol Infect Dis. 2011;30:951-6 pubmed publisher
    ..A major impetigo epidemic and calls for antibiotic stewardship with increased utilisation of specimens were contributing factors...
  41. Janny S, Bert F, Dondero F, Chanoine M, Belghiti J, Mantz J, et al. Fatal Escherichia coli skin and soft tissue infections in liver transplant recipients: report of three cases. Transpl Infect Dis. 2013;15:E49-53 pubmed publisher
    Gram-negative bacilli are unusual agents of skin and soft tissue infections. Most previous cases have been reported in cirrhotic or immunocompromised patients, including a single case in a liver transplant recipient...
  42. Fritz S, Hogan P, Camins B, Ainsworth A, Patrick C, Martin M, et al. Mupirocin and chlorhexidine resistance in Staphylococcus aureus in patients with community-onset skin and soft tissue infections. Antimicrob Agents Chemother. 2013;57:559-68 pubmed publisher
    ..including mupirocin and chlorhexidine, are often prescribed to prevent Staphylococcus aureus skin and soft tissue infections (SSTI)...
  43. Maina E, Kiiyukia C, Wamae C, Waiyaki P, Kariuki S. Characterization of methicillin-resistant Staphylococcus aureus from skin and soft tissue infections in patients in Nairobi, Kenya. Int J Infect Dis. 2013;17:e115-9 pubmed publisher
    Skin and soft tissue infections (SSTIs) are among the most common infectious diseases and a frequent cause of hospital visits...
  44. Sobhy N, Aly F, Abd El Kader O, Ghazal A, Elbaradei A. Community-acquired methicillin-resistant Staphylococcus aureus from skin and soft tissue infections (in a sample of Egyptian population): analysis of mec gene and staphylococcal cassette chromosome. Braz J Infect Dis. 2012;16:426-31 pubmed publisher
    ..Community-acquired methicillin-resistant S. aureus (CA-MRSA) infections commonly present as skin and soft-tissue infections (SSTIs). Treatment often includes incision and drainage with or without adjunctive antibiotics...
  45. Jenkins T, Sabel A, Sarcone E, Price C, Mehler P, Burman W. Skin and soft-tissue infections requiring hospitalization at an academic medical center: opportunities for antimicrobial stewardship. Clin Infect Dis. 2010;51:895-903 pubmed publisher
    ..Frequent use of potentially unnecessary diagnostic studies, broad-spectrum antibiotic therapy, and prolonged treatment courses in these patients suggest targets for antimicrobial stewardship programs. ..
  46. Dryden M. Complicated skin and soft tissue infections caused by methicillin-resistant Staphylococcus aureus: epidemiology, risk factors, and presentation. Surg Infect (Larchmt). 2008;9 Suppl 1:s3-10 pubmed publisher
    Complicated skin and soft tissue infections (cSSTIs) present a challenge to healthcare providers. Methicillin-resistant Staphylococcus aureus (MRSA) is an increasing cause of these infections, particularly in certain countries...
  47. Jacobsson G, Dashti S, Wahlberg T, Andersson R. The epidemiology of and risk factors for invasive Staphylococcus aureus infections in western Sweden. Scand J Infect Dis. 2007;39:6-13 pubmed
    ..One- quarter of the patients had no history of fever, and one-third of the bacteraemia patients had normal white blood cell count (<10 x 10(9)/l) at presentation. All cases were of MSSA (methicillin-sensitive Staphylococcus aureus). ..
  48. Larsen A, Stegger M, Böcher S, Sørum M, Monnet D, Skov R. Emergence and characterization of community-associated methicillin-resistant Staphyloccocus aureus infections in Denmark, 1999 to 2006. J Clin Microbiol. 2009;47:73-8 pubmed publisher
    ..CA-MRSA was associated with a young age, skin and soft tissue infections, and non-Danish origin. Transmission between household members was frequently reported...
  49. Creech C, Beekmann S, Chen Y, Polgreen P. Variability among pediatric infectious diseases specialists in the treatment and prevention of methicillin-resistant Staphylococcus aureus skin and soft tissue infections. Pediatr Infect Dis J. 2008;27:270-2 pubmed publisher
    ..the treatment and prevention of community-associated methicillin-resistant Staphylococcus aureus skin and soft tissue infections in pediatric patients...
  50. Frei C, Makos B, Daniels K, Oramasionwu C. Emergence of community-acquired methicillin-resistant Staphylococcus aureus skin and soft tissue infections as a common cause of hospitalization in United States children. J Pediatr Surg. 2010;45:1967-74 pubmed publisher
    ..Since then, possible risk factors for contracting CA-MRSA have been hypothesized, but supporting studies are limited...
  51. Paydar K, Hansen S, Charlebois E, Harris H, Young D. Inappropriate antibiotic use in soft tissue infections. Arch Surg. 2006;141:850-4; discussion 855-6 pubmed
    Many soft tissue infections treated with surgical drainage resolve even when treated with antibiotics not active against the organism isolated from the infection. Retrospective. Integrated Soft Tissue Infection Services clinic...
  52. Petkovsek Z, Elersic K, Gubina M, Zgur Bertok D, Starcic Erjavec M. Virulence potential of Escherichia coli isolates from skin and soft tissue infections. J Clin Microbiol. 2009;47:1811-7 pubmed publisher
    Escherichia coli strains frequently are isolated from skin and soft tissue infections (SSTI); however, their virulence potential has not yet been extensively studied. In the present study, we characterized 102 E...
  53. Napolitano L. Early appropriate parenteral antimicrobial treatment of complicated skin and soft tissue infections caused by methicillin-resistant Staphylococcus aureus. Surg Infect (Larchmt). 2008;9 Suppl 1:s17-27 pubmed publisher
    Complicated skin and soft tissue infections (cSSTIs) are a major clinical problem, in part because of the increasing resistance of infecting bacteria to our current antibiotic therapies...
  54. Quigley A, Gnanasegaran G, Buscombe J, Hilson A. Technetium-99m-labelled sulesomab (LeukoScan) in the evaluation of soft tissue infections. Med Princ Pract. 2008;17:447-52 pubmed publisher
    To perform a retrospective review of all patients receiving technetium-99m ((99m)Tc)-labelled sulesomab over a 4-year period to determine if soft tissue infections can be accurately identified.
  55. Shen H, Lu C. Skin and soft tissue infections in hospitalized and critically ill patients: a nationwide population-based study. BMC Infect Dis. 2010;10:151 pubmed publisher
    The proportional distributions of various skin and soft tissue infections (SSTIs) with/without intensive care are unclear...
  56. David M, Mennella C, Mansour M, Boyle Vavra S, Daum R. Predominance of methicillin-resistant Staphylococcus aureus among pathogens causing skin and soft tissue infections in a large urban jail: risk factors and recurrence rates. J Clin Microbiol. 2008;46:3222-7 pubmed publisher
    ..All skin and soft tissue infections (SSTIs) cultured in the Cook County Jail in March 2004 to August 2005 were reviewed...
  57. Daum R. Clinical practice. Skin and soft-tissue infections caused by methicillin-resistant Staphylococcus aureus. N Engl J Med. 2007;357:380-90 pubmed
  58. Ruhe J, Smith N, Bradsher R, Menon A. Community-onset methicillin-resistant Staphylococcus aureus skin and soft-tissue infections: impact of antimicrobial therapy on outcome. Clin Infect Dis. 2007;44:777-84 pubmed
    ..Conflicting data exist on the role of antimicrobial therapy for the treatment of uncomplicated community-onset methicillin-resistant Staphylococcus aureus (MRSA) skin and soft-tissue infections (SSTIs)...
  59. McCaig L, McDonald L, Mandal S, Jernigan D. Staphylococcus aureus-associated skin and soft tissue infections in ambulatory care. Emerg Infect Dis. 2006;12:1715-23 pubmed
    To describe the number and treatment of skin and soft tissue infections likely caused by Staphylococcus aureus in the United States, we analyzed data from the 1992-1994 and 2001-2003 National Ambulatory Medical Care Surveys and National ..
  60. Rivera Olivero I, Guevara A, Escalona A, Oliver M, Pérez Alfonzo R, Piquero J, et al. [Soft-tissue infections due to non-tuberculous mycobacteria following mesotherapy. What is the price of beauty]. Enferm Infecc Microbiol Clin. 2006;24:302-6 pubmed
  61. Sreeramoju P, Porbandarwalla N, Arango J, Latham K, Dent D, Stewart R, et al. Recurrent skin and soft tissue infections due to methicillin-resistant Staphylococcus aureus requiring operative debridement. Am J Surg. 2011;201:216-20 pubmed publisher
    The aim of this study was to examine clinical factors associated with the recurrence of community-onset skin and soft tissue infections caused by methicillin-resistant Staphylococcus aureus.
  62. Szumowski J, Cohen D, Kanaya F, Mayer K. Treatment and outcomes of infections by methicillin-resistant Staphylococcus aureus at an ambulatory clinic. Antimicrob Agents Chemother. 2007;51:423-8 pubmed
    Community-acquired methicillin-resistant Staphylococcus aureus (MRSA) skin and soft tissue infections (SSTI) have become increasingly common...