spondylarthritis

Summary

Summary: Inflammation of the joints of the SPINE, the intervertebral articulations.

Top Publications

  1. Baraliakos X, Braun J. Spondyloarthritides. Best Pract Res Clin Rheumatol. 2011;25:825-42 pubmed publisher
    ..As far as it stands now, TNF blockers seem to have no influence on new bone formation in AS...
  2. Ritchlin C. Therapeutic considerations in spondyloarthritis patients who fail tumour necrosis factor antagonists. Best Pract Res Clin Rheumatol. 2010;24:683-92 pubmed publisher
  3. Maksymowych W. Biomarkers in spondyloarthritis. Curr Rheumatol Rep. 2010;12:318-24 pubmed publisher
  4. Madsen K, Egund N, Jurik A. Grading of inflammatory disease activity in the sacroiliac joints with magnetic resonance imaging: comparison between short-tau inversion recovery and gadolinium contrast-enhanced sequences. J Rheumatol. 2010;37:393-400 pubmed publisher
  5. Althoff C, Sieper J, Song I, Haibel H, Weiß A, Diekhoff T, et al. Active inflammation and structural change in early active axial spondyloarthritis as detected by whole-body MRI. Ann Rheum Dis. 2013;72:967-73 pubmed publisher
    ..To evaluate active inflammatory lesions (AIL) and structural changes (SC) in patients with active non-radiographic axial spondyloarthritis (nr-axSpA) compared with patients with ankylosing spondylitis (AS) on whole-body MRI (wb-MRI)...
  6. Poddubnyy D, Rudwaleit M. Early spondyloarthritis. Rheum Dis Clin North Am. 2012;38:387-403 pubmed publisher
    ..This article discusses the current concept of the disease, typical manifestations, advances in diagnosis, and current treatment recommendations...
  7. Sieper J, van der Heijde D, Dougados M, Mease P, Maksymowych W, Brown M, et al. Efficacy and safety of adalimumab in patients with non-radiographic axial spondyloarthritis: results of a randomised placebo-controlled trial (ABILITY-1). Ann Rheum Dis. 2013;72:815-22 pubmed publisher
    ..To evaluate the efficacy and safety of adalimumab in patients with non-radiographic axial spondyloarthritis (nr-axSpA)...
  8. Poddubnyy D, Brandt H, Vahldiek J, Spiller I, Song I, Rudwaleit M, et al. The frequency of non-radiographic axial spondyloarthritis in relation to symptom duration in patients referred because of chronic back pain: results from the Berlin early spondyloarthritis clinic. Ann Rheum Dis. 2012;71:1998-2001 pubmed publisher
  9. Weisman M, Learch T, Baraliakos X, Chandran V, Gladman D, Raychaudhuri S, et al. Current controversies in spondyloarthritis: SPARTAN. J Rheumatol. 2010;37:2617-23 pubmed publisher
    ..Presentations also were made on psoriasis in the SCID mouse model; the challenges and opportunities of SpA in China; a discussion of the special needs in managing SpA in Ibero-America, and the SPARK Survey in Europe and North America...

More Information

Publications72

  1. Dougados M, D Agostino M, Benessiano J, Berenbaum F, Breban M, Claudepierre P, et al. The DESIR cohort: a 10-year follow-up of early inflammatory back pain in France: study design and baseline characteristics of the 708 recruited patients. Joint Bone Spine. 2011;78:598-603 pubmed publisher
  2. Song I, Hermann K, Haibel H, Althoff C, Poddubnyy D, Listing J, et al. Relationship between active inflammatory lesions in the spine and sacroiliac joints and new development of chronic lesions on whole-body MRI in early axial spondyloarthritis: results of the ESTHER trial at week 48. Ann Rheum Dis. 2011;70:1257-63 pubmed publisher
  3. Poddubnyy D, Rudwaleit M, Haibel H, Listing J, Märker Hermann E, Zeidler H, et al. Rates and predictors of radiographic sacroiliitis progression over 2 years in patients with axial spondyloarthritis. Ann Rheum Dis. 2011;70:1369-74 pubmed publisher
    ..To assess the progression of radiographic sacroiliitis in a cohort of patients with early axial spondyloarthritis over a period of 2 years and to explore predictors of progression...
  4. Yeremenko N, Noordenbos T, Cantaert T, van Tok M, van de Sande M, Canete J, et al. Disease-specific and inflammation-independent stromal alterations in spondylarthritis synovitis. Arthritis Rheum. 2013;65:174-85 pubmed publisher
    The molecular processes driving the distinct patterns of synovial inflammation and tissue remodeling in spondylarthritis (SpA) as compared to rheumatoid arthritis (RA) remain largely unknown...
  5. Gu J, Wei Y, Wei J, Huang F, Jan M, Centola M, et al. Identification of RGS1 as a candidate biomarker for undifferentiated spondylarthritis by genome-wide expression profiling and real-time polymerase chain reaction. Arthritis Rheum. 2009;60:3269-79 pubmed publisher
    To compare gene expression profiles between ankylosing spondylitis (AS) and undifferentiated spondylarthritis (uSpA) patients with inflammatory low back pain.
  6. Poddubnyy D, Haibel H, Listing J, Märker Hermann E, Zeidler H, Braun J, et al. Baseline radiographic damage, elevated acute-phase reactant levels, and cigarette smoking status predict spinal radiographic progression in early axial spondylarthritis. Arthritis Rheum. 2012;64:1388-98 pubmed publisher
    To assess prospectively the rates and to explore predictors of spinal radiographic progression over 2 years in a cohort of patients with early axial spondylarthritis (SpA).
  7. Cantaert T, Doorenspleet M, Francosalinas G, Paramarta J, Klarenbeek P, Tiersma Y, et al. Increased numbers of CD5+ B lymphocytes with a regulatory phenotype in spondylarthritis. Arthritis Rheum. 2012;64:1859-68 pubmed publisher
    Whether and how B lymphocytes contribute to the pathogenesis of spondylarthritis (SpA), a seronegative arthritis associated with gut inflammation, remains unknown...
  8. Ruutu M, Thomas G, Steck R, Degli Esposti M, Zinkernagel M, Alexander K, et al. ?-glucan triggers spondylarthritis and Crohn's disease-like ileitis in SKG mice. Arthritis Rheum. 2012;64:2211-22 pubmed publisher
    ..This study was undertaken to determine whether SKG mice injected with 1,3-?-glucan (curdlan) develop evidence of SpA, and the relationship of innate and adaptive autoimmunity to this process...
  9. Madsen K, Jurik A. Magnetic resonance imaging grading system for active and chronic spondylarthritis changes in the sacroiliac joint. Arthritis Care Res (Hoboken). 2010;62:11-8 pubmed publisher
    To develop a new grading method to quantify activity and chronic spondylarthritis (SpA) changes in the sacroiliac (SI) joints identified by magnetic resonance imaging (MRI), taking into account the complex joint anatomy, and to compare ..
  10. Rudwaleit M, Sieper J. Referral strategies for early diagnosis of axial spondyloarthritis. Nat Rev Rheumatol. 2012;8:262-8 pubmed publisher
  11. Kluger N, Cohen P, Fallet Bianco C, Guillevin L. Mycobacterium chelonae infection under adalimumab therapy for spondylarthritis. Clin Exp Rheumatol. 2010;28:101-2 pubmed
    ..Skin biopsy with histological examination and oriented microbiological cultures and molecular identification are mandatory to confirm the diagnosis...
  12. Aydin S, Maksymowych W, Bennett A, McGonagle D, Emery P, Marzo Ortega H. Validation of the ASAS criteria and definition of a positive MRI of the sacroiliac joint in an inception cohort of axial spondyloarthritis followed up for 8 years. Ann Rheum Dis. 2012;71:56-60 pubmed publisher
    ..To aid implementation, ASAS has proposed a definition of a positive MRI for active sacroiliitis...
  13. Dougados M, Simon P, Braun J, Burgos Vargas R, Maksymowych W, Sieper J, et al. ASAS recommendations for collecting, analysing and reporting NSAID intake in clinical trials/epidemiological studies in axial spondyloarthritis. Ann Rheum Dis. 2011;70:249-51 pubmed publisher
    ..This initiative should facilitate the conduct and analysis of clinical studies/trials...
  14. Pedersen S, Hetland M, Sørensen I, Ostergaard M, Nielsen H, Johansen J. Circulating levels of interleukin-6, vascular endothelial growth factor, YKL-40, matrix metalloproteinase-3, and total aggrecan in spondyloarthritis patients during 3 years of treatment with TNF? inhibitors. Clin Rheumatol. 2010;29:1301-9 pubmed publisher
    ..Larger prospective studies are required to clarify clinical utility of these biomarkers...
  15. Dougados M, Baeten D. Spondyloarthritis. Lancet. 2011;377:2127-37 pubmed publisher
  16. Méric J, Mulleman D, Ducourau E, Lauféron F, Miow Lin D, Watier H, et al. Therapeutic drug monitoring of infliximab in spondyloarthritis: an observational open-label study. Ther Drug Monit. 2011;33:411-6 pubmed publisher
    ..We investigated whether a knowledge of infliximab serum concentration modifies physician decision and improves the control of disease activity in SpA...
  17. Busquets Pérez N, Marzo Ortega H, Emery P. Emerging drugs for axial spondyloarthritis including ankylosing spondylitis. Expert Opin Emerg Drugs. 2013;18:71-86 pubmed publisher
    ..Only non-steroidal anti-inflammatories (NSAIDs) and TNF inhibitors (TNFi) are effective in ankylosing spondylitis (AS). However, not all patients successfully respond to these drugs and a subset may have contraindications to their use...
  18. Pedersen S, Sørensen I, Lambert R, Hermann K, Garnero P, Johansen J, et al. Radiographic progression is associated with resolution of systemic inflammation in patients with axial spondylarthritis treated with tumor necrosis factor ? inhibitors: a study of radiographic progression, inflammation on magnetic resonance imaging, . Arthritis Rheum. 2011;63:3789-800 pubmed publisher
    ..COMP]), and bone turnover (CTX-I and osteocalcin) to inflammation on magnetic resonance imaging (MRI) and radiographic progression in patients with axial spondylarthritis (SpA) beginning tumor necrosis factor ? (TNF?) inhibitor therapy.
  19. Arnbak B, Leboeuf Yde C, Jensen T. A systematic critical review on MRI in spondyloarthritis. Arthritis Res Ther. 2012;14:R55 pubmed publisher
    ..The aims were to identify which MRI findings are associated with the diagnosis of SpA and to quantify this association...
  20. Utriainen L, Firmin D, Wright P, Cerovic V, Breban M, McInnes I, et al. Expression of HLA-B27 causes loss of migratory dendritic cells in a rat model of spondylarthritis. Arthritis Rheum. 2012;64:3199-209 pubmed publisher
    ..Therefore, B27-transgenic rats provide a model of spondylarthritis. Because inflammation in these rats requires CD4+ T lymphocytes and involves intestinal pathology, we ..
  21. Song I, Weiß A, Hermann K, Haibel H, Althoff C, Poddubnyy D, et al. Similar response rates in patients with ankylosing spondylitis and non-radiographic axial spondyloarthritis after 1 year of treatment with etanercept: results from the ESTHER trial. Ann Rheum Dis. 2013;72:823-5 pubmed publisher
    ..We assessed whether there is a difference to etanercept (ETA) treatment in patients with ankylosing spondylitis (AS) compared with non-radiographic axial SpA (nr-axSpA) patients with a disease duration <5 years...
  22. Dougados M, Combe B, Braun J, Landewe R, Sibilia J, Cantagrel A, et al. A randomised, multicentre, double-blind, placebo-controlled trial of etanercept in adults with refractory heel enthesitis in spondyloarthritis: the HEEL trial. Ann Rheum Dis. 2010;69:1430-5 pubmed publisher
    ..The objective of this study was to investigate the efficacy of etanercept in refractory heel enthesitis related to SpA...
  23. Weber U, Lambert R, Østergaard M, Hodler J, Pedersen S, Maksymowych W. The diagnostic utility of magnetic resonance imaging in spondylarthritis: an international multicenter evaluation of one hundred eighty-seven subjects. Arthritis Rheum. 2010;62:3048-58 pubmed publisher
    ..assess the diagnostic utility of magnetic resonance imaging (MRI) to differentiate patients with spondylarthritis (SpA) from patients with nonspecific back pain and healthy volunteers, using a standardized evaluation of MR ..
  24. Liao Z, Lin Z, Xu M, Hu Z, Li T, Wei Q, et al. Clinical features of axial undifferentiated spondyloarthritis (USpA) in China: HLA-B27 is more useful for classification than MRI of the sacroiliac joint. Scand J Rheumatol. 2011;40:439-43 pubmed publisher
  25. Van Praet L, Van den Bosch F, Mielants H, Elewaut D. Mucosal inflammation in spondylarthritides: past, present, and future. Curr Rheumatol Rep. 2011;13:409-15 pubmed publisher
    ..In this paper, we focus on the clinical, genetic, and pathophysiologic overlap of SpA and IBD. Furthermore, we discuss some of the targets that may influence therapeutic decision making...
  26. Chung H, Machado P, van der Heijde D, D Agostino M, Dougados M. HLA-B27 positive patients differ from HLA-B27 negative patients in clinical presentation and imaging: results from the DESIR cohort of patients with recent onset axial spondyloarthritis. Ann Rheum Dis. 2011;70:1930-6 pubmed publisher
    ..To clarify the influence of human leucocyte antigen B27 (HLA-B27) status on the phenotype of early axial spondyloarthritis (SpA)...
  27. Noordenbos T, Yeremenko N, Gofita I, van de Sande M, Tak P, Canete J, et al. Interleukin-17-positive mast cells contribute to synovial inflammation in spondylarthritis. Arthritis Rheum. 2012;64:99-109 pubmed publisher
    Studies comparing spondylarthritis (SpA) to rheumatoid arthritis (RA) synovitis suggest that innate immune cells may play a predominant role in the pathogenesis of SpA...
  28. van der Heijde D, Sieper J, Maksymowych W, Dougados M, Burgos Vargas R, Landewe R, et al. 2010 Update of the international ASAS recommendations for the use of anti-TNF agents in patients with axial spondyloarthritis. Ann Rheum Dis. 2011;70:905-8 pubmed publisher
    ..Sulfasalazine is no longer mandatory in this group of patients. Finally, efficacy should be evaluated after at least 12 weeks. The remaining recommendations stayed largely unchanged...
  29. Taurog J, Rival C, van Duivenvoorde L, Satumtira N, Dorris M, Sun M, et al. Autoimmune epididymoorchitis is essential to the pathogenesis of male-specific spondylarthritis in HLA-B27-transgenic rats. Arthritis Rheum. 2012;64:2518-28 pubmed publisher
    ..human ?(2) -microglobulin (h?(2) m) spontaneously develop epididymoorchitis (EO) preceding the development of spondylarthritis (SpA)...
  30. Payeli S, Kollnberger S, Marroquin Belaunzaran O, Thiel M, McHugh K, Giles J, et al. Inhibiting HLA-B27 homodimer-driven immune cell inflammation in spondylarthritis. Arthritis Rheum. 2012;64:3139-49 pubmed publisher
    ..This study was undertaken to produce an antibody to HLA-B27(2) in order to confirm its expression in SpA and to inhibit its proinflammatory properties...
  31. Rudwaleit M, van der Heijde D, Landewe R, Akkoc N, Brandt J, Chou C, et al. The Assessment of SpondyloArthritis International Society classification criteria for peripheral spondyloarthritis and for spondyloarthritis in general. Ann Rheum Dis. 2011;70:25-31 pubmed publisher
    ..To evaluate new classification criteria for peripheral spondyloarthritis (SpA) in patients with SpA with peripheral manifestations only...
  32. Lories R, Schett G. Pathophysiology of new bone formation and ankylosis in spondyloarthritis. Rheum Dis Clin North Am. 2012;38:555-67 pubmed publisher
    ..In addition, proposed biomarkers of new bone formation are evaluated and the translational current and future challenges are discussed with regards to new bone formation in spondyloarthritis...
  33. Dhaenens M, Fert I, Glatigny S, Haerinck S, Poulain C, Donnadieu E, et al. Dendritic cells from spondylarthritis-prone HLA-B27-transgenic rats display altered cytoskeletal dynamics, class II major histocompatibility complex expression, and viability. Arthritis Rheum. 2009;60:2622-32 pubmed publisher
    b>Spondylarthritis (SpA) is characterized by spinal and peripheral joint inflammation, frequently combined with extraarticular manifestations...
  34. Iagnocco A, Riente L, Delle Sedie A, Filippucci E, Salaffi F, Meenagh G, et al. Ultrasound imaging for the rheumatologist. XXII. Achilles tendon involvement in spondyloarthritis. A multi-centre study using high frequency volumetric probe. Clin Exp Rheumatol. 2009;27:547-51 pubmed
    ..Our study for the first time demonstrated that 3D US is a valid imaging modality for the assessment of Achilles tendon enthesitis...
  35. Toussirot E. Late-onset ankylosing spondylitis and spondylarthritis: an update on clinical manifestations, differential diagnosis and pharmacological therapies. Drugs Aging. 2010;27:523-31 pubmed publisher
    Ankylosing spondylitis (AS) and spondylarthritis (SpA) are generally observed in young male patients but can be diagnosed in the elderly. These cases correspond to late-onset or late-diagnosed AS or SpA...
  36. Hermann K, Baraliakos X, Van der Heijde D, Jurik A, Landewe R, Marzo Ortega H, et al. Descriptions of spinal MRI lesions and definition of a positive MRI of the spine in axial spondyloarthritis: a consensual approach by the ASAS/OMERACT MRI study group. Ann Rheum Dis. 2012;71:1278-88 pubmed publisher
    ..The aim of this study was to define characteristic MRI findings in the spine of patients with axial spondyloarthritis (SpA) and provide a definition of a positive spinal MRI for inflammation and structural changes...
  37. Sieper J. Developments in therapies for spondyloarthritis. Nat Rev Rheumatol. 2012;8:280-7 pubmed publisher
    ..New classification criteria for peripheral SpA will also allow treatment trials to be conducted more systematically than has previously been possible in this subgroup of patients...
  38. Braun J, Inman R. Clinical significance of inflammatory back pain for diagnosis and screening of patients with axial spondyloarthritis. Ann Rheum Dis. 2010;69:1264-8 pubmed publisher
    ..The value of IBP for diagnosis of SpA increases in the presence of other more or less sensitive and specific features of SpA such as response to exercise and physical therapy and/or treatment with non-steroidal anti-inflammatory agents...
  39. De Vos M, Hindryckx P, Laukens D. Novel development in extraintestinal manifestations and spondylarthropathy. Best Pract Res Clin Gastroenterol. 2011;25 Suppl 1:S19-26 pubmed publisher
    The important co-existence of spondylarthritis (SpA) and inflammatory bowel disease (IBD) within the same individual suggests common etiopathogenic mechanisms...
  40. Song I, Hermann K, Haibel H, Althoff C, Althoff C, Listing J, et al. Effects of etanercept versus sulfasalazine in early axial spondyloarthritis on active inflammatory lesions as detected by whole-body MRI (ESTHER): a 48-week randomised controlled trial. Ann Rheum Dis. 2011;70:590-6 pubmed publisher
    ..To evaluate the potential of etanercept versus sulfasalazine to reduce active inflammatory lesions on whole-body MRI in active axial spondyloarthritis with a symptom duration of less than 5 years...
  41. Gladman D, Inman R, Cook R, Maksymowych W, Braun J, Davis J, et al. International spondyloarthritis interobserver reliability exercise--the INSPIRE study: II. Assessment of peripheral joints, enthesitis, and dactylitis. J Rheumatol. 2007;34:1740-5 pubmed
    ..Enthesitis instruments can be used reliably in patients with AS and patients with PsA with spinal involvement. The Leeds dactylitis instrument functions well in PsA. ..
  42. Falsetti P, Frediani B, Filippou G, Acciai C, Baldi F, Storri L, et al. Enthesitis of proximal insertion of the deltoid in the course of seronegative spondyloarthritis. An atypical enthesitis that can mime impingement syndrome. Scand J Rheumatol. 2002;31:158-62 pubmed
    ..DPIE can determine shoulder pain in the course of SpA, and in particular in PsA. The clinical manifestations of DPIE are very similar to those of an impingement syndrome; sonography can differentiate the two conditions. ..
  43. Rohekar G, Inman R. Conundrums in nosology: synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome and spondylarthritis. Arthritis Rheum. 2006;55:665-9 pubmed
  44. Heuft Dorenbosch L, Landewe R, Weijers R, Houben H, van der Linden S, Jacobs P, et al. Performance of various criteria sets in patients with inflammatory back pain of short duration; the Maastricht early spondyloarthritis clinic. Ann Rheum Dis. 2007;66:92-8 pubmed
    ..In this cohort, the contribution of MRI and human leucocyte antigen B27 to purely clinical criteria in making a diagnosis of axial SpA was limited. ..
  45. Breban M. Genetics of spondyloarthritis. Best Pract Res Clin Rheumatol. 2006;20:593-9 pubmed
    ..The current concept of SpA heterogeneity has been challenged by family studies which showed that all articular and extra-articular manifestations were linked together, and most likely to the same genetic factors. ..
  46. Rudwaleit M, van der Heijde D, Landewe R, Listing J, Akkoc N, Brandt J, et al. The development of Assessment of SpondyloArthritis international Society classification criteria for axial spondyloarthritis (part II): validation and final selection. Ann Rheum Dis. 2009;68:777-83 pubmed publisher
    ..To validate and refine two sets of candidate criteria for the classification/diagnosis of axial spondyloarthritis (SpA)...
  47. Homeff G, Burgos Vargas R. TNF-alpha antagonists for the treatment of juvenile-onset spondyloarthritides. Clin Exp Rheumatol. 2002;20:S137-42 pubmed
    ..However, without further studies no recommendations can be provided for indication for treatment, dosing, intervals and duration of treatment. ..
  48. McMichael A, Bowness P. HLA-B27: natural function and pathogenic role in spondyloarthritis. Arthritis Res. 2002;4 Suppl 3:S153-8 pubmed
    ..We are currently investigating the possibility that such interactions could be involved in disease pathogenesis. ..
  49. Zinovieva E, Lebrun N, Letourneur F, Laurent F, Said Nahal R, Chiocchia G, et al. Lack of association between Tenascin-C gene and spondyloarthritis. Rheumatology (Oxford). 2008;47:1655-8 pubmed publisher
    ..However, we cannot exclude that variants located in intronic regions or in the vicinity of TNC, which were not tested in the present study, could be implicated in the predisposition to SpA. ..
  50. Eshed I, Bollow M, McGonagle D, Tan A, Althoff C, Asbach P, et al. MRI of enthesitis of the appendicular skeleton in spondyloarthritis. Ann Rheum Dis. 2007;66:1553-9 pubmed
    ..The MRI appearances of inflammatory and degenerative enthesopathy are described. New options for imaging enthesitis, including whole-body MRI and high-resolution microscopy MRI, are briefly discussed. ..
  51. Rudwaleit M, Landewe R, van der Heijde D, Listing J, Brandt J, Braun J, et al. The development of Assessment of SpondyloArthritis international Society classification criteria for axial spondyloarthritis (part I): classification of paper patients by expert opinion including uncertainty appraisal. Ann Rheum Dis. 2009;68:770-6 pubmed publisher
    ..The objective of this study was to develop candidate classification criteria for axial SpA that include patients with but also without radiographic sacroiliitis...
  52. Marzo Ortega H, McGonagle D, O CONNOR P, Emery P. Efficacy of etanercept for treatment of Crohn's related spondyloarthritis but not colitis. Ann Rheum Dis. 2003;62:74-6 pubmed
    ..These findings suggest that the effect of TNFalpha blockade in SpA differs between the joint and the bowel...
  53. Chan A, Kollnberger S, Wedderburn L, Bowness P. Expansion and enhanced survival of natural killer cells expressing the killer immunoglobulin-like receptor KIR3DL2 in spondylarthritis. Arthritis Rheum. 2005;52:3586-95 pubmed
    ..We therefore undertook the present study to determine the number and function of NK and T cells bearing KIR3DL2 in SpA...
  54. Braun J, Zochling J, Baraliakos X, Alten R, Burmester G, Grasedyck K, et al. Efficacy of sulfasalazine in patients with inflammatory back pain due to undifferentiated spondyloarthritis and early ankylosing spondylitis: a multicentre randomised controlled trial. Ann Rheum Dis. 2006;65:1147-53 pubmed
    ..To assess the effect of sulfasalazine (SSZ) on inflammatory back pain (IBP) due to active undifferentiated spondyloarthritis (uSpA) or ankylosing spondylitis in patients with symptom duration <5 years...
  55. Rihl M, Kellner H, Kellner W, Barthel C, Yu D, Tak P, et al. Identification of interleukin-7 as a candidate disease mediator in spondylarthritis. Arthritis Rheum. 2008;58:3430-5 pubmed publisher
    Understanding of the molecular pathophysiology of spondylarthritis (SpA) remains largely elusive...
  56. Maksymowych W, Dhillon S, Park R, Salonen D, Inman R, Lambert R. Validation of the spondyloarthritis research consortium of Canada magnetic resonance imaging spinal inflammation index: is it necessary to score the entire spine?. Arthritis Rheum. 2007;57:501-7 pubmed
    ..Scoring of the entire spine limits feasibility and a scoring method that records inflammation in only the more severely affected spinal segments may improve feasibility without sacrificing performance...
  57. Zeboulon N, Dougados M, Gossec L. Prevalence and characteristics of uveitis in the spondyloarthropathies: a systematic literature review. Ann Rheum Dis. 2008;67:955-9 pubmed
    ..Uveitis is reported to be the most common extra-articular manifestation in spondyloarthritis (SpA); however, its prevalence and characteristics are not well established...
  58. Benjamin M, McGonagle D. Histopathologic changes at "synovio-entheseal complexes" suggesting a novel mechanism for synovitis in osteoarthritis and spondylarthritis. Arthritis Rheum. 2007;56:3601-9 pubmed
    ..To determine the extent to which different entheses form part of a "synovio-entheseal complex" (SEC) and whether such SECs are commonly associated with the presence of inflammatory cells and evidence of enthesis microdamage...
  59. Rudwaleit M, Haibel H, Baraliakos X, Listing J, Märker Hermann E, Zeidler H, et al. The early disease stage in axial spondylarthritis: results from the German Spondyloarthritis Inception Cohort. Arthritis Rheum. 2009;60:717-27 pubmed publisher
    ..whether patients without definite radiographically defined sacroiliitis, referred to as nonradiographic axial spondylarthritis (SpA), are different from patients with AS with regard to clinical manifestations and disease activity ..
  60. Carter J, Gerard H, Espinoza L, Ricca L, Valeriano J, Snelgrove J, et al. Chlamydiae as etiologic agents in chronic undifferentiated spondylarthritis. Arthritis Rheum. 2009;60:1311-6 pubmed publisher
    ..The aim of the present study was to assess the prevalence of synovial Chlamydia trachomatis and Chlamydia pneumoniae infections in patients with chronic undifferentiated spondylarthritis (uSpA).
  61. Barkham N, Keen H, Coates L, O Connor P, Hensor E, Fraser A, et al. Clinical and imaging efficacy of infliximab in HLA-B27-Positive patients with magnetic resonance imaging-determined early sacroiliitis. Arthritis Rheum. 2009;60:946-54 pubmed publisher
    ..To evaluate the efficacy of infliximab in HLA-B27-positive patients with magnetic resonance imaging (MRI)-determined early sacroiliitis, using both clinical and MRI assessments...
  62. Demetter P, De Vos M, Van Huysse J, Baeten D, Ferdinande L, Peeters H, et al. Colon mucosa of patients both with spondyloarthritis and Crohn's disease is enriched with macrophages expressing the scavenger receptor CD163. Ann Rheum Dis. 2005;64:321-4 pubmed
    ..Crohn's disease is associated with an increased number of macrophages in ileal and colonic mucosa. Data on macrophages in gut mucosa of patients with spondyloarthritis (SpA) are scarce...
  63. Muñoz Fernández S, de Miguel E, Cobo Ibáñez T, Madero R, Ferreira A, Hidalgo M, et al. Enthesis inflammation in recurrent acute anterior uveitis without spondylarthritis. Arthritis Rheum. 2009;60:1985-90 pubmed publisher
    To investigate whether patients with idiopathic recurrent acute anterior uveitis (AAU) have enthesis alterations comparable with those in patients with spondylarthritis (SpA).