chronic wasting disease

Summary

Summary: A transmissible spongiform encephalopathy (prion disease) of DEER and elk characterized by chronic weight loss leading to death. It is thought to spread by direct contact between animals or through environmental contamination with the prion protein (PRIONS).

Top Publications

  1. O Rourke K, Spraker T, Zhuang D, Greenlee J, Gidlewski T, Hamir A. Elk with a long incubation prion disease phenotype have a unique PrPd profile. Neuroreport. 2007;18:1935-8 pubmed
    ..PRNP gene is associated with variation in relative susceptibility and incubation time in the cervid TSE chronic wasting disease. We now report that elk lacking the predisposing 132-methionine allele develop chronic wasting disease ..
  2. Wolfe L, Spraker T, Gonzalez L, Dagleish M, Sirochman T, Brown J, et al. PrPCWD in rectal lymphoid tissue of deer (Odocoileus spp.). J Gen Virol. 2007;88:2078-82 pubmed
    The utility of rectal lymphoid tissue sampling for the diagnosis of chronic wasting disease (CWD) infections in mule deer (Odocoileus hemionus) and white-tailed deer (Odocoileus virginianus) was evaluated...
  3. Krumm C, Conner M, Miller M. Relative vulnerability of chronic wasting disease infected mule deer to vehicle collisions. J Wildl Dis. 2005;41:503-11 pubmed
    We estimated chronic wasting disease (CWD) prevalence among vehicle-killed mule deer (Odocoileus hemionus) in select data analysis units (DAUs) in northern Colorado, USA, and compared these with estimated CWD prevalence among mule deer ..
  4. Lupi O. Risk analysis of ectoparasites acting as vectors for chronic wasting disease. Med Hypotheses. 2005;65:47-54 pubmed
    ..Animal prion infections, such as chronic wasting disease (CWD) and scrapie (sheep) have shown a pattern of horizontal transmission...
  5. O Rourke K, Spraker T, Hamburg L, Besser T, Brayton K, Knowles D. Polymorphisms in the prion precursor functional gene but not the pseudogene are associated with susceptibility to chronic wasting disease in white-tailed deer. J Gen Virol. 2004;85:1339-46 pubmed
    b>Chronic wasting disease (CWD) status and PrP genotypes were determined for a group of 133 wild white-tailed deer in a 780 acre enclosure in western Nebraska, USA...
  6. Angers R, Browning S, Seward T, Sigurdson C, Miller M, Hoover E, et al. Prions in skeletal muscles of deer with chronic wasting disease. Science. 2006;311:1117 pubmed
    The emergence of chronic wasting disease (CWD) in deer and elk in an increasingly wide geographic area, as well as the interspecies transmission of bovine spongiform encephalopathy to humans in the form of variant Creutzfeldt Jakob ..
  7. Sigurdson C. A prion disease of cervids: chronic wasting disease. Vet Res. 2008;39:41 pubmed publisher
    b>Chronic wasting disease (CWD) is a prion disease of deer, elk, and moose, initially recognized in Colorado mule deer...
  8. Garruto R, Reiber C, Alfonso M, Gastrich H, Needham K, Sunderman S, et al. Risk behaviors in a rural community with a known point-source exposure to chronic wasting disease. Environ Health. 2008;7:31 pubmed publisher
    The emergence and continuing spread of Chronic Wasting Disease (CWD) in cervids has now reached 14 U.S...
  9. Keane D, Barr D, Bochsler P, Hall S, Gidlewski T, O Rourke K, et al. Chronic wasting disease in a Wisconsin white-tailed deer farm. J Vet Diagn Invest. 2008;20:698-703 pubmed
    In September 2002, chronic wasting disease (CWD), a prion disorder of captive and wild cervids, was diagnosed in a white-tailed deer (Odocoileus virginianus) from a captive farm in Wisconsin...

More Information

Publications62

  1. Miller M, Wild M. Epidemiology of chronic wasting disease in captive white-tailed and mule deer. J Wildl Dis. 2004;40:320-7 pubmed
    The natural occurrence of chronic wasting disease (CWD) in a 1993 cohort of captive white-tailed deer (Odocoileus virginianus) afforded the opportunity to describe epidemic dynamics in this species and to compare dynamics with those seen ..
  2. Spraker T, Gidlewski T, Balachandran A, VerCauteren K, Creekmore L, Munger R. Detection of PrP(CWD) in postmortem rectal lymphoid tissues in Rocky Mountain elk (Cervus elaphus nelsoni) infected with chronic wasting disease. J Vet Diagn Invest. 2006;18:553-7 pubmed
    ..The utility of examining the rectal mucosal lymphoid tissues to detect chronic wasting disease (CWD) was investigated in Rocky Mountain elk (Cervus elaphus nelsoni), a species for which there is not a ..
  3. Seelig D, Mason G, Telling G, Hoover E. Pathogenesis of chronic wasting disease in cervidized transgenic mice. Am J Pathol. 2010;176:2785-97 pubmed publisher
    b>Chronic wasting disease (CWD) is a fatal, endemic prion disease of wild and captive cervids, including deer, elk, and moose...
  4. Race B, Meade White K, Miller M, Barbian K, Rubenstein R, LaFauci G, et al. Susceptibilities of nonhuman primates to chronic wasting disease. Emerg Infect Dis. 2009;15:1366-76 pubmed publisher
    b>Chronic wasting disease (CWD) is a transmissible spongiform encephalopathy, or prion disease, that affects deer, elk, and moose. Human susceptibility to CWD remains unproven despite likely exposure to CWD-infected cervids...
  5. Angers R, Kang H, Napier D, Browning S, Seward T, Mathiason C, et al. Prion strain mutation determined by prion protein conformational compatibility and primary structure. Science. 2010;328:1154-8 pubmed publisher
    ..Additionally, the frequency of strains causing chronic wasting disease (CWD), a burgeoning prion epidemic of cervids, is unknown...
  6. Hoey J. Wild game feasts and fatal degenerative neurologic illness. CMAJ. 2003;169:443 pubmed
  7. Hamir A, Kunkle R, Miller J, Hall S. Abnormal prion protein in ectopic lymphoid tissue in a kidney of an asymptomatic white-tailed deer experimentally inoculated with the agent of chronic wasting disease. Vet Pathol. 2006;43:367-9 pubmed
    b>Chronic wasting disease (CWD), a transmissible spongiform encephalopathy (TSE) of deer and elk, is one of a group of fatal, neurologic diseases that affect several mammalian species, including human beings...
  8. TAMGUNEY G, Giles K, Bouzamondo Bernstein E, Bosque P, Miller M, Safar J, et al. Transmission of elk and deer prions to transgenic mice. J Virol. 2006;80:9104-14 pubmed
    b>Chronic wasting disease (CWD) is a fatal prion disease in deer and elk. Unique among the prion diseases, it is transmitted among captive and free-ranging animals...
  9. Sigurdson C, Aguzzi A. Chronic wasting disease. Biochim Biophys Acta. 2007;1772:610-8 pubmed
    Until recently, chronic wasting disease of cervids, the only prion disease affecting wildlife, was believed to be geographically concentrated to Colorado and Wyoming within the United States...
  10. Belay E, Maddox R, Williams E, Miller M, Gambetti P, Schonberger L. Chronic wasting disease and potential transmission to humans. Emerg Infect Dis. 2004;10:977-84 pubmed
    b>Chronic wasting disease (CWD) of deer and elk is endemic in a tri-corner area of Colorado, Wyoming, and Nebraska, and new foci of CWD have been detected in other parts of the United States...
  11. TAMGUNEY G, Miller M, Giles K, Lemus A, Glidden D, Dearmond S, et al. Transmission of scrapie and sheep-passaged bovine spongiform encephalopathy prions to transgenic mice expressing elk prion protein. J Gen Virol. 2009;90:1035-47 pubmed publisher
    b>Chronic wasting disease (CWD) is a transmissible, fatal prion disease of cervids and is largely confined to North America...
  12. Trifilo M, Ying G, Teng C, Oldstone M. Chronic wasting disease of deer and elk in transgenic mice: oral transmission and pathobiology. Virology. 2007;365:136-43 pubmed
    To study the pathogenesis of chronic wasting disease (CWD) in deer and elk, transgenic (tg) mice were generated that expressed the prion protein (PrP) of deer containing a glycine at amino acid (aa) 96 and a serine at aa 225 under ..
  13. Race B, Meade White K, Ward A, Jewell J, Miller M, Williams E, et al. Levels of abnormal prion protein in deer and elk with chronic wasting disease. Emerg Infect Dis. 2007;13:824-30 pubmed
    b>Chronic wasting disease (CWD) of deer and elk is a widespread health concern because its potential for crossspecies transmission is undetermined...
  14. Raymond G, Raymond L, Meade White K, Hughson A, Favara C, Gardner D, et al. Transmission and adaptation of chronic wasting disease to hamsters and transgenic mice: evidence for strains. J Virol. 2007;81:4305-14 pubmed
    ..using the cell-free prion protein conversion system indicated that certain rodents may be susceptible to chronic wasting disease (CWD)...
  15. Johnson C, Johnson J, Clayton M, McKenzie D, Aiken J. Prion protein gene heterogeneity in free-ranging white-tailed deer within the chronic wasting disease affected region of Wisconsin. J Wildl Dis. 2003;39:576-81 pubmed
    b>Chronic wasting disease (CWD) was first identified in Wisconsin (USA) in whitetailed deer (Odocoileus virginianus) in February 2002...
  16. Ernest H, Hoar B, Well J, O Rourke K. Molecular genealogy tools for white-tailed deer with chronic wasting disease. Can J Vet Res. 2010;74:153-6 pubmed
    ..Spread of chronic wasting disease (CWD), a prion disorder of deer and their cervid relatives, is presumed to be associated with direct ..
  17. Kurt T, Perrott M, Wilusz C, Wilusz J, Supattapone S, Telling G, et al. Efficient in vitro amplification of chronic wasting disease PrPRES. J Virol. 2007;81:9605-8 pubmed
    b>Chronic wasting disease (CWD) of cervids is associated with conversion of the normal cervid prion protein, PrP(C), to a protease-resistant conformer, PrP(CWD)...
  18. Sandberg M, Al Doujaily H, Sigurdson C, Glatzel M, O Malley C, Powell C, et al. Chronic wasting disease prions are not transmissible to transgenic mice overexpressing human prion protein. J Gen Virol. 2010;91:2651-7 pubmed publisher
    b>Chronic wasting disease (CWD) is a prion disease that affects free-ranging and captive cervids, including mule deer, white-tailed deer, Rocky Mountain elk and moose...
  19. LaFauci G, Carp R, Meeker H, Ye X, Kim J, Natelli M, et al. Passage of chronic wasting disease prion into transgenic mice expressing Rocky Mountain elk (Cervus elaphus nelsoni) PrPC. J Gen Virol. 2006;87:3773-80 pubmed
    b>Chronic wasting disease (CWD) of elk (Cervus elaphus nelsoni) and mule deer (Odocoileus hemionus) is one of three naturally occurring forms of prion disease, the others being Creutzfeldt-Jakob disease in humans and scrapie in sheep...
  20. Huang H, Rendulich J, Stevenson D, O Rourke K, Balachandran A. Evaluation of Western blotting methods using samples with or without sodium phosphotungstic acid precipitation for diagnosis of scrapie and chronic wasting disease. Can J Vet Res. 2005;69:193-9 pubmed
    ..Western blot (WB) test for use as an alternative and confirmatory method for the diagnosis of scrapie and chronic wasting disease (CWD) in Canada by comparing 2 sample preparation procedures: an abnormal prion protein (PrPSc) ..
  21. Kim T, Shon H, Joo Y, Mun U, Kang K, Lee Y. Additional cases of Chronic Wasting Disease in imported deer in Korea. J Vet Med Sci. 2005;67:753-9 pubmed
    b>Chronic Wasting Disease (CWD), which had previously occurred only in the U.S.A. and Canada, broke out in a farm at Chungbuk, Korea from imported Canadian deer (Aug. 8, 2001)...
  22. Spraker T, O Rourke K, Gidlewski T, Powers J, Greenlee J, Wild M. Detection of the abnormal isoform of the prion protein associated with chronic wasting disease in the optic pathways of the brain and retina of Rocky Mountain elk (Cervus elaphus nelsoni). Vet Pathol. 2010;47:536-46 pubmed publisher
    ..Tissues were examined for the presence of the abnormal isoform of the prion protein associated with chronic wasting disease (PrP(CWD))...
  23. Miller M, Conner M. Epidemiology of chronic wasting disease in free-ranging mule deer: spatial, temporal, and demographic influences on observed prevalence patterns. J Wildl Dis. 2005;41:275-90 pubmed
    We analyzed chronic wasting disease (CWD) prevalence data from mule deer populations in northcentral Colorado, USA, to discern the likely influences of temporal, spatial, and demographic factors on patterns observed in naturally infected ..
  24. Bian J, Napier D, Khaychuck V, Angers R, Graham C, Telling G. Cell-based quantification of chronic wasting disease prions. J Virol. 2010;84:8322-6 pubmed publisher
    ..diseased elk, we describe a modification of the scrapie cell assay allowing evaluation of prions causing chronic wasting disease, a naturally occurring transmissible spongiform encephalopathy...
  25. Beekes M, McBride P. The spread of prions through the body in naturally acquired transmissible spongiform encephalopathies. FEBS J. 2007;274:588-605 pubmed
    ..This holds true also for scrapie in sheep, bovine spongiform encephalopathy in cattle, chronic wasting disease in elk and deer, or variant Creutzfeldt-Jakob disease in humans, all of which are assumed to originate ..
  26. Brayton K, O Rourke K, Lyda A, Miller M, Knowles D. A processed pseudogene contributes to apparent mule deer prion gene heterogeneity. Gene. 2004;326:167-73 pubmed
    ..Comparable data have not been derived for mule deer, a species susceptible to the TSE chronic wasting disease (CWD)...
  27. Saunders S, Bartz J, VerCauteren K, Bartelt Hunt S. Enzymatic digestion of chronic wasting disease prions bound to soil. Environ Sci Technol. 2010;44:4129-35 pubmed publisher
    b>Chronic wasting disease (CWD) and sheep scrapie can be transmitted via indirect environmental routes, and it is known that soil can serve as a reservoir of prion infectivity...
  28. Browning S, Mason G, Seward T, Green M, Eliason G, Mathiason C, et al. Transmission of prions from mule deer and elk with chronic wasting disease to transgenic mice expressing cervid PrP. J Virol. 2004;78:13345-50 pubmed
    We generated mice expressing cervid prion protein to produce a transgenic system simulating chronic wasting disease (CWD) in deer and elk...
  29. Heisey D, Mickelsen N, Schneider J, Johnson C, Johnson C, Langenberg J, et al. Chronic wasting disease (CWD) susceptibility of several North American rodents that are sympatric with cervid CWD epidemics. J Virol. 2010;84:210-5 pubmed publisher
    b>Chronic wasting disease (CWD) is a highly contagious always fatal neurodegenerative disease that is currently known to naturally infect only species of the deer family, Cervidae...
  30. Nichols T, Pulford B, Wyckoff A, Meyerett C, Michel B, Gertig K, et al. Detection of protease-resistant cervid prion protein in water from a CWD-endemic area. Prion. 2009;3:171-83 pubmed
    b>Chronic wasting disease (CWD) is the only known transmissible spongiform encephalopathy affecting free-ranging wildlife...
  31. Balachandran A, Harrington N, Algire J, Soutyrine A, Spraker T, Jeffrey M, et al. Experimental oral transmission of chronic wasting disease to red deer (Cervus elaphus elaphus): early detection and late stage distribution of protease-resistant prion protein. Can Vet J. 2010;51:169-78 pubmed
    b>Chronic wasting disease (CWD), an important emerging prion disease of cervids, is readily transmitted by intracerebral or oral inoculation from deer-to-deer and elk-to-elk, suggesting the latter is a natural route of exposure...
  32. Sohn H, Kim J, Choi K, Nah J, Joo Y, Jean Y, et al. A case of chronic wasting disease in an elk imported to Korea from Canada. J Vet Med Sci. 2002;64:855-8 pubmed
    ..All the remaining elk and deer that had been in contact with this elk were destroyed and negative for chronic wasting disease (CWD). To our knowledge, this is the first case of CWD occurring outside of the U.S.A. and Canada.
  33. Kahn S, Dubé C, Bates L, Balachandran A. Chronic wasting disease in Canada: Part 1. Can Vet J. 2004;45:397-404 pubmed
    The purpose of part 1 is to provide an overview of published literature (1980-2002) on chronic wasting disease (CWD) to inform Canadian readers about the disease and to explain Canadian regulatory approaches to the surveillance and ..
  34. Safar J, Scott M, Monaghan J, Deering C, Didorenko S, Vergara J, et al. Measuring prions causing bovine spongiform encephalopathy or chronic wasting disease by immunoassays and transgenic mice. Nat Biotechnol. 2002;20:1147-50 pubmed
    ..CDI was able to discriminate between PrP(Sc) from BSE-infected cattle and Tg(BoPrP) mice as well as from chronic wasting disease (CWD)-infected deer and elk...
  35. TAMGUNEY G, Miller M, Wolfe L, Sirochman T, Glidden D, Palmer C, et al. Asymptomatic deer excrete infectious prions in faeces. Nature. 2009;461:529-32 pubmed publisher
    Infectious prion diseases-scrapie of sheep and chronic wasting disease (CWD) of several species in the deer family-are transmitted naturally within affected host populations...
  36. Hamir A, Kunkle R, Miller J, Greenlee J, Richt J. Experimental second passage of chronic wasting disease (CWD(mule deer)) agent to cattle. J Comp Pathol. 2006;134:63-9 pubmed
    To compare clinicopathological findings in first and second passage chronic wasting disease (CWD(mule deer)) in cattle, six calves were inoculated intracerebrally with brain tissue derived from a first-passage CWD-affected calf in an ..
  37. Jennelle C, Samuel M, Nolden C, Keane D, Barr D, Johnson C, et al. Surveillance for transmissible spongiform encephalopathy in scavengers of white-tailed deer carcasses in the chronic wasting disease area of Wisconsin. J Toxicol Environ Health A. 2009;72:1018-24 pubmed publisher
    b>Chronic wasting disease (CWD), a class of neurodegenerative transmissible spongiform encephalopathies (TSE) occurring in cervids, is found in a number of states and provinces across North America...
  38. Green K, Browning S, Seward T, Jewell J, Ross D, Green M, et al. The elk PRNP codon 132 polymorphism controls cervid and scrapie prion propagation. J Gen Virol. 2008;89:598-608 pubmed publisher
    ..methionine (M) or leucine (L) at codon 132, the L132 allele apparently affording protection against chronic wasting disease (CWD)...
  39. Gossert A, Bonjour S, Lysek D, Fiorito F, Wuthrich K. Prion protein NMR structures of elk and of mouse/elk hybrids. Proc Natl Acad Sci U S A. 2005;102:646-50 pubmed
    ..These results are evaluated in the context of recent reports on chronic wasting disease (CWD) in captive and free-ranging deer and elk in the U.S...
  40. Bosque P. Bovine spongiform encephalopathy, chronic wasting disease, scrapie, and the threat to humans from prion disease epizootics. Curr Neurol Neurosci Rep. 2002;2:488-95 pubmed
    ..A large, and apparently growing, epidemic of chronic wasting disease plagues deer and elk in North America...
  41. Raymond G, Olsen E, Lee K, Raymond L, Bryant P, Baron G, et al. Inhibition of protease-resistant prion protein formation in a transformed deer cell line infected with chronic wasting disease. J Virol. 2006;80:596-604 pubmed
    b>Chronic wasting disease (CWD) is an emerging transmissible spongiform encephalopathy (prion disease) of North American cervids, i.e., mule deer, white-tailed deer, and elk (wapiti)...
  42. Haley N, Seelig D, Zabel M, Telling G, Hoover E. Detection of CWD prions in urine and saliva of deer by transgenic mouse bioassay. PLoS ONE. 2009;4:e4848 pubmed publisher
    b>Chronic wasting disease (CWD) is a prion disease affecting captive and free-ranging cervids (e.g. deer, elk, and moose). The mechanisms of CWD transmission are poorly understood, though bodily fluids are thought to play an important role...
  43. Perucchini M, Griffin K, Miller M, Goldmann W. PrP genotypes of free-ranging wapiti (Cervus elaphus nelsoni) with chronic wasting disease. J Gen Virol. 2008;89:1324-8 pubmed publisher
    Variation in PrP prion gene sequence appears to modulate susceptibility to chronic wasting disease (CWD), a naturally occurring prion disease affecting four North American species of the family Cervidae...
  44. Miller M, Williams E, Hobbs N, Wolfe L. Environmental sources of prion transmission in mule deer. Emerg Infect Dis. 2004;10:1003-6 pubmed
    Whether transmission of the chronic wasting disease (CWD) prion among cervids requires direct interaction with infected animals has been unclear...
  45. Mathiason C, Powers J, Dahmes S, Osborn D, Miller K, Warren R, et al. Infectious prions in the saliva and blood of deer with chronic wasting disease. Science. 2006;314:133-6 pubmed
    A critical concern in the transmission of prion diseases, including chronic wasting disease (CWD) of cervids, is the potential presence of prions in body fluids...
  46. Joly D, Ribic C, Langenberg J, Beheler K, Batha C, Dhuey B, et al. Chronic wasting disease in free-ranging Wisconsin White-tailed Deer. Emerg Infect Dis. 2003;9:599-601 pubmed
    Three White-tailed Deer shot within 5 km during the 2001 hunting season in Wisconsin tested positive for chronic wasting disease, a prion disease of cervids. Subsequent sampling within 18 km showed a 3% prevalence (n=476)...
  47. Meade White K, Race B, Trifilo M, Bossers A, Favara C, LaCasse R, et al. Resistance to chronic wasting disease in transgenic mice expressing a naturally occurring allelic variant of deer prion protein. J Virol. 2007;81:4533-9 pubmed
    ..For example, expression of deer or elk PrP in transgenic mice has induced susceptibility to chronic wasting disease (CWD), the prion disease of cervids...
  48. Jewell J, Brown J, Kreeger T, Williams E. Prion protein in cardiac muscle of elk (Cervus elaphus nelsoni) and white-tailed deer (Odocoileus virginianus) infected with chronic wasting disease. J Gen Virol. 2006;87:3443-50 pubmed
    To investigate the possible presence of disease-associated prion protein (PrP(d)) in striated muscle of chronic wasting disease (CWD)-affected cervids, samples of diaphragm, tongue, heart and three appendicular skeletal muscles from mule ..
  49. Kurt T, Telling G, Zabel M, Hoover E. Trans-species amplification of PrP(CWD) and correlation with rigid loop 170N. Virology. 2009;387:235-43 pubmed publisher
    b>Chronic wasting disease (CWD) is an efficiently transmitted spongiform encephalopathy of cervids. Whether CWD could represent a threat to non-cervid species remains speculative...
  50. Williams E. Scrapie and chronic wasting disease. Clin Lab Med. 2003;23:139-59 pubmed
    ..This technique holds promise for antemortem diagnosis of infection in the peripheral lymphoid tissues such as lymphoid follicles of the nictitating membrane and the tonsil. ..
  51. Belay E, Schonberger L. The public health impact of prion diseases. Annu Rev Public Health. 2005;26:191-212 pubmed
    ..disease (CJD), the possible occurrence of variant CJD (vCJD), and potential zoonotic transmission of chronic wasting disease (CWD)...
  52. Marsh R, Kincaid A, Bessen R, Bartz J. Interspecies transmission of chronic wasting disease prions to squirrel monkeys (Saimiri sciureus). J Virol. 2005;79:13794-6 pubmed
    b>Chronic wasting disease (CWD) is an emerging prion disease of deer and elk. The risk of CWD transmission to humans following exposure to CWD-infected tissues is unknown...
  53. Race R, Raines A, Baron T, Miller M, Jenny A, Williams E. Comparison of abnormal prion protein glycoform patterns from transmissible spongiform encephalopathy agent-infected deer, elk, sheep, and cattle. J Virol. 2002;76:12365-8 pubmed
    Analysis of abnormal prion protein glycoform patterns from chronic wasting disease (CWD)-affected deer and elk, scrapie-affected sheep and cattle, and cattle with bovine spongiform encephalopathy failed to identify patterns capable of ..