pseudorabies

Summary

Alias: aujeszky disease
Summary: A highly contagious herpesvirus infection affecting the central nervous system of swine, cattle, dogs, cats, rats, and other animals.

Webpages

  1. entrez gene statistics
    www.ncbi.nih.gov/projects/Gene/gentrez_stats.cgi?TAXORG=1029 ...
  2. herd infection through semen
    www.omaf.gov.on.ca/english/livestock/swine/facts/infectio.ht ...
  3. comparative ophthalmology notes: literature cited
    www.vetmed.ucdavis.edu/courses/vet_eyes/conotes/con_literatu ...
  4. pigs - vaccines
    www.intervet.com/species/pigs/vaccines.aspx
  5. novartis animal health us, inc
    www.livestock.novartis.com/swine.html
  6. iowa pork industry center
    www.ipic.iastate.edu/topics.html
  7. cdfa > ahfss > animal health > animal diseases
    www.cdfa.ca.gov/ahfss/Animal_Health/Disease.html
  8. virology
    addl.purdue.edu/userguide/virology/vir_result.asp?agent=West ...
  9. pigs - products
    www.intervet.com/species/pigs/products.aspx
  10. virology
    addl.purdue.edu/userguide/virology/vir_result.asp?agent=Ente ...

Research Grants

  1. 33rd International Herpesvirus Workshop
    Jay A Nelson; Fiscal Year: 2008
  2. 28th International Herpesvirus Workshop,
    Jay A Nelson; Fiscal Year: 2007
  3. International Herpesvirus Workshop, Cairns, Australia
    Jay A Nelson; Fiscal Year: 2002
  4. Restraint stress-induced neurogenic bladder inflammation
    Theoharis C Theoharides; Fiscal Year: 2006
  5. Genetic Analysis of Herpesvirus Tropism and Virulence
    Lynn W Enquist; Fiscal Year: 2008
  6. Genetic Analysis of Herpesvirus Tropism and Virulence
    Lynn W Enquist; Fiscal Year: 2007
  7. Role of Intraspinal Plasticity in Autonomic Dysreflexia
    Alexander G Rabchevsky; Fiscal Year: 2008
  8. Role of Intraspinal Plasticity in Autonomic Dysreflexia
    Alexander G Rabchevsky; Fiscal Year: 2007
  9. Brainstem control of pain transmission
    Allan I Basbaum; Fiscal Year: 2008
  10. EFFECT OF DENERVATION ON THE FUNCTION OF THE AIRWAYS
    J JULIO PEREZ FONTAN; Fiscal Year: 2004

Publications

  1. Vaccine-induced T cell-mediated immunity plays a critical role in early protection against pseudorabies virus (suid herpes virus type 1) infection in pigs
    E M A van Rooij
    Central Institute for Animal Disease Control, CIDC Lelystad, P O Box 2004, 8203 AA Lelystad, The Netherlands
    Vet Immunol Immunopathol 99:113-25
  2. An approach to a FMD vaccine based on genetic engineered attenuated pseudorabies virus: one experiment using VP1 gene alone generates an antibody responds on FMD and pseudorabies in swine
    Ping Qian
    Laboratory of Animal Virology, College of Veterinary Medical Sciences, Huazhong Agricultural University, Wuhan 430070, PR China
    Vaccine 22:2129-36
  3. A DNA vaccine coding for gB and gD of pseudorabies virus (suid herpes type 1) primes the immune system in the presence of maternal immunity more efficiently than conventional vaccines
    E M A van Rooij
    Central Institute for Animal Disease Control, CIDC Lelystad, P O Box 2004, 8203 AA, Lelystad, The Netherlands
    Vaccine 24:1264-73
  4. Effect of transgenic expression of porcine interleukin-6 gene and CpG sequences on immune responses of newborn piglets inoculated with Pseudorabies attenuated vaccine
    Zhang Ling Hua
    School of Bioscience and Bioengineering, South China University of Technology, Guangzhou 510640, China
    Res Vet Sci 80:281-6
  5. Vaccination with the glycoprotein D gene of pseudorabies virus delivered by nonpathogenic Escherichia coli elicits protective immune responses
    A L Shiau
    Department of Microbiology, National Cheng Kung University Medical College, 701, Tainan, Taiwan
    Vaccine 19:3277-84
  6. Vaccination of pigs with a recombinant porcine adenovirus expressing the gD gene from pseudorabies virus
    J M Hammond
    CSIRO, Livestock Industries, Private Mail Bag 24, Australian Animal Health Laboratory, Geelong, Victoria 3220, Australia
    Vaccine 19:3752-8
  7. Antibody response of wild boar (Sus scrofa) piglets vaccinated against Aujeszky's disease virus
    F Ruiz-Fons
    Instituto de Investigación en Recursos Cinegéticos IREC (CSIC-UCLM-JCCM, Ronda de Toledo s/n, 13071, Cuidad Real, Spain
    Vet Rec 162:484-5
  8. Immunogenicity of a recombinant pseudorabies virus expressing ORF1-ORF2 fusion protein of porcine circovirus type 2
    Chunmei Ju
    Laboratory of Animal Virology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, PR China
    Vet Microbiol 109:179-90
  9. An analysis of a presumed major outbreak of pseudorabies virus in a vaccinated sow herd
    A van Nes
    Department of Farm Animal Health, University of Utrecht, The Netherlands
    Epidemiol Infect 126:119-28
  10. The use of different vaccination schedules for sows to protect piglets against Aujeszky's disease
    J Casal
    CReSA, Centre de Recerca en Sanitat Animal, Dep Sanitat i Anatomia Animals, Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    J Vet Med B Infect Dis Vet Public Health 51:8-11

Scientific Experts

Detail Information

Webpages81 found, 30 most recent shown here

  1. entrez gene statistics
    www.ncbi.nih.gov/projects/Gene/gentrez_stats.cgi?TAXORG=1029 ...
  2. herd infection through semen
    www.omaf.gov.on.ca/english/livestock/swine/facts/infectio.ht ...
  3. comparative ophthalmology notes: literature cited
    www.vetmed.ucdavis.edu/courses/vet_eyes/conotes/con_literatu ...
  4. pigs - vaccines
    www.intervet.com/species/pigs/vaccines.aspx
  5. novartis animal health us, inc
    www.livestock.novartis.com/swine.html
  6. iowa pork industry center
    www.ipic.iastate.edu/topics.html
  7. cdfa > ahfss > animal health > animal diseases
    www.cdfa.ca.gov/ahfss/Animal_Health/Disease.html
  8. virology
    addl.purdue.edu/userguide/virology/vir_result.asp?agent=West ...
  9. pigs - products
    www.intervet.com/species/pigs/products.aspx
  10. virology
    addl.purdue.edu/userguide/virology/vir_result.asp?agent=Ente ...
  11. canadian food inspection agency - animal disease information
    www.inspection.gc.ca/english/anima/disemala/disemalae.shtml
  12. usda - aphis - wildlife damage management
    www.aphis.usda.gov/wildlife_damage/nwrc/research/pseudorabie ...
  13. serology
    www.addl.purdue.edu/userguide/serology/filter.asp?name=LEP
  14. swine diseases - pseudorabies
    www.vetmed.iastate.edu/departments/vdpam/swine/diseases/ches ...
  15. virology at waddl at washington state university
    www.vetmed.wsu.edu/depts_waddl/virology.aspx
  16. nebraska department of agriculture
    www.agr.ne.gov/regulate/regulate.htm
  17. comparative placentation
    placentation.ucsd.edu/pig.html
  18. ronald m. weigel, pathology, college of veterinary medicine, u of i at illinois
    www.cvm.uiuc.edu/faculty/vp/weigel.html
  19. information resources on ferrets
    www.nal.usda.gov/awic/pubs/ferrets/viruses.htm
  20. ronald m. weigel, pathology, college of veterinary medicine, u of i at illinois
    www.cvm.uiuc.edu/faculty/path/weigel.html
  21. weiss' personal page
    www-personal.ksu.edu/~mlweiss/
  22. brain and behavior (iphy 3730), university of colorado at boulder
    www.colorado.edu/intphys/Class/IPHY3730/06methodology.html
  23. livestock/poultry contact form
    www.idexx.com/production/contact/contactpas.jsp
  24. nvsl laboratory certification
    www.aphis.usda.gov/vs/nvsl/Labs/labcertification.htm
  25. idexx herdchek prv antibody test kit
    www.idexx.com/production/swine/swine1.jsp
  26. rabies prevention in livestock, vme-1-97
    ohioline.osu.edu/vme-fact/0001.html
  27. cdfa > ahfss > animal health home
    www.cdfa.ca.gov/ahfss/ah/anthrax_info.htm

Research Grants39

  1. 33rd International Herpesvirus Workshop
    Jay A Nelson; Fiscal Year: 2008
    ..Animal herpesviruses pose a significant economic impact to poultry (Marek's and others), swine (pseudorabies virus), cattle (several bovine herpesviruses) and horses (several equine herpesviruses)...
  2. 28th International Herpesvirus Workshop,
    Jay A Nelson; Fiscal Year: 2007
    ..Animal herpesviruses are of significant economic importance to poultry (Marek's and others), swine (pseudorabies virus), cattle (several bovine herpesviruses) and horses (several equine herpesviruses)...
  3. International Herpesvirus Workshop, Cairns, Australia
    Jay A Nelson; Fiscal Year: 2002
    ..Animal herpes significant economic importance to the poultry (Marek's and others), swine (pseudorabies virus), cattle (several bovine herpesviruses) and horses (several equine herpesviruses)...
  4. Restraint stress-induced neurogenic bladder inflammation
    Theoharis C Theoharides; Fiscal Year: 2006
    ..shown that bladder inflammation could not occur in mast cell deficient mice infected with the neurotropic pseudorabies virus...
  5. Genetic Analysis of Herpesvirus Tropism and Virulence
    Lynn W Enquist; Fiscal Year: 2008
    ..I work with pseudorabies virus (PRV), a well-studied alpha herpesvirus causing a disease of economic impact in swine, but also infecting ..
  6. Genetic Analysis of Herpesvirus Tropism and Virulence
    Lynn W Enquist; Fiscal Year: 2007
    ..I work with pseudorabies virus (PRV), a well-studied alpha herpesvirus causing a disease of economic impact in swine, but also infecting ..
  7. Role of Intraspinal Plasticity in Autonomic Dysreflexia
    Alexander G Rabchevsky; Fiscal Year: 2008
    ..tracing of biotinylated dextran amine (BDA) from the L6/S 1 cord, and retrograde transsynaptic tracing of pseudorabies virus (PRV) from sympathetic pre-vertebral ganglia to identify the neural pathways that transmit visceral ..
  8. Role of Intraspinal Plasticity in Autonomic Dysreflexia
    Alexander G Rabchevsky; Fiscal Year: 2007
    ..tracing of biotinylated dextran amine (BDA) from the L6/S 1 cord, and retrograde transsynaptic tracing of pseudorabies virus (PRV) from sympathetic pre-vertebral ganglia to identify the neural pathways that transmit visceral ..
  9. Brainstem control of pain transmission
    Allan I Basbaum; Fiscal Year: 2008
    ..We will use Cre-recombinase-dependent pseudorabies virus transneuronal retrograde tracing to study selectively the circuits that regulate different populations of ..
  10. EFFECT OF DENERVATION ON THE FUNCTION OF THE AIRWAYS
    J JULIO PEREZ FONTAN; Fiscal Year: 2004
    ..under the transcriptional control of the PPT-A 5' regulatory region in conjunction with tracking studies using pseudorabies virus as a retrograde trans-synaptic marker...
  11. Photoperiodic Control of Obesity
    TIMOTHY JON BARTNESS; Fiscal Year: 2008
    ..WAT pads, brown fat and adrenal medulla using multiple variants of a transneuronal viral tract tracer (pseudorabies virus [PRV])...
  12. Photoperiodic Control of Obesity
    TIMOTHY JON BARTNESS; Fiscal Year: 2006
    ..WAT pads, brown fat and adrenal medulla using multiple variants of a transneuronal viral tract tracer (pseudorabies virus [PRV])...
  13. Photoperiodic Control of Obesity
    TIMOTHY JON BARTNESS; Fiscal Year: 2007
    ..WAT pads, brown fat and adrenal medulla using multiple variants of a transneuronal viral tract tracer (pseudorabies virus [PRV])...
  14. The Role of Us9 in Herpesvirus Neuroinvasion
    Mathew G Lyman; Fiscal Year: 2008
    ..This will aid the search for more delivery- specific, less pathogenic herpesvirus vectors. Specific Aims: Pseudorabies virus (PRV), a close relative to herpes simplex virus (HSV), infects and spreads within the peripheral and ..
  15. Developmental Plasticity of Micturition Reflexes
    MARGARET ANN VIZZARD; Fiscal Year: 2005
    ..A combination of transneuronal tracing with pseudorabies virus (Bartha strain) and conventional retrograde dye mapping techniques (Fluorogold) will be utilized...
  16. Herpes Simplex Virus FC Receptor
    HARVEY MICHAEL FRIEDMAN; Fiscal Year: 2008
    ..This defect distinguishes HSV-1 gE from pseudorabies virus (PRV) gE, since PRV gE is not required for retrograde spread...
  17. A Novel Neural Pathway Controls Testosterone Release
    Catherine L Rivier; Fiscal Year: 2007
    ..characterize this pathway by combining the intratesticular injection of the retrograde transganglionic tracer pseudorabies virus with the Fos response that is elicited in various brain regions by the icv injection of alcohol...
  18. Alpha-Herpesvirus Transport in Axons
    Gregory Allan Smith; Fiscal Year: 2008
    ..human viruses varicella-zoster virus (VZV) and herpes simplex virus (HSV) types 1 and 2, and the animal virus pseudorabies virus (PRV)...
  19. A Novel Neural Pathway Controls Testosterone Release
    Catherine L Rivier; Fiscal Year: 2008
    ..characterize this pathway by combining the intratesticular injection of the retrograde transganglionic tracer pseudorabies virus with the Fos response that is elicited in various brain regions by the icv injection of alcohol...
  20. Retinal Neurons Afferent to the Circadian System
    Gary E Pickard; Fiscal Year: 2008
    ..use melanopsin as a chromophore and neurons afferent to melanopsin-expressing cells will be identified using pseudorabies virus (PRV) as a transneuronal tracer...
  21. Retinal Neurons Afferent to the Circadian System
    Gary E Pickard; Fiscal Year: 2008
    ..use melanopsin as a chromophore and neurons afferent to melanopsin-expressing cells will be identified using pseudorabies virus (PRV) as a transneuronal tracer...
  22. TRANSPORT OF HERPESVIRUS MEMBRANE PROTEINS IN NEURITES
    ENRIQUE A FLOOD; Fiscal Year: 2003
    ..mechanisms of viral invasion and spread in the mammalian nervous system-by neurotropic herpesviruses, using pseudorabies virus (PRV) as a model virus...
  23. TRH and Energy Homeostasis
    Ronald M Lechan; Fiscal Year: 2006
    ..This approach, together with the use of genetically modified pseudorabies virus (PRV) that exploits the Cre-loxP system for conditional replication and expression of the fluorescent ..
  24. Retinal Neurons Afferent to the Circadian System
    Gary E Pickard; Fiscal Year: 2007
    ..use melanopsin as a chromophore and neurons afferent to melanopsin-expressing cells will be identified using pseudorabies virus (PRV) as a transneuronal tracer...
  25. Genetic system for thesus monkey rhadinovirus (RRV)
    Blossom A Damania; Fiscal Year: 2005
    ..BAC) encoding the entire RRV genome using a self-recombining Cre-Lox strategy previously used to create the pseudorabies virus BAC...
  26. Alpha-Herpesvirus Transport in Axons
    Gregory Allan Smith; Fiscal Year: 2007
    ..human viruses varicella-zoster virus (VZV) and herpes simplex virus (HSV) types 1 and 2, and the animal virus pseudorabies virus (PRV)...
  27. Regulation of Thermogenesis by the Melanocortin System
    Wei Fan; Fiscal Year: 2006
    ..goals, we will first use injection into peripheral effector tissue of the trans-synaptic retrograde tracer, pseudorabies virus, to characterize the neuroanatomical substrate(s) through which the melanocortin system regulates ..
  28. Role of gM and gE in herpesvirus infection of neurons
    Lisa E Pomeranz; Fiscal Year: 2004
    ..Our understanding of alphaherpesvirus assembly and spread in the nervous system is still in its early stages. Pseudorabies virus (PRV) is an alphaherpesvirus closely related to HSV and VZV...
  29. AFFERENT CONTROL OF LOCUS COERULEUS
    GARY S ASTON-JONES; Fiscal Year: 2002
    ..that specifically innervate extranuclear LC dendrites using the recently developed transsynaptic tract-tracer, pseudorabies virus (PRV)...
  30. PLASTICITY OF LUT INTERNEURONS FOLLOWING SPINAL CORD INJ
    MARGARET ANN VIZZARD; Fiscal Year: 2004
    ..neurons in the lumbosacral spinal cord (L6-S1) using a combination of transneuronal tracing with pseudorabies virus (PRV) and conventional retrograde dye tracing techniques (Fluorogold) in control and SCI animals...
  31. Vestibular Influences on Head Direction Cell Activity
    Bill J Yates; Fiscal Year: 2004
    ..Specific Aim 1 tests the hypothesis that injection of the retrograde transneuronal tracer pseudorabies virus into two areas containing HDC, the anterior dorsal nucleus of the thalamus and lateral mammillary nuclei, ..
  32. SWALLOWING--BUCCOPHARYNGEAL/ESOPHAGEAL COORDINATION
    Steven M Altschuler; Fiscal Year: 2002
    ..Transsynaptic tracing with Pseudorabies Virus in conjunction with: (1) Fluorescent retrograde tracing will be utilized to study the anatomical ..
  33. Integrative mechanisms of cortical circuits
    Gordon M Shepherd; Fiscal Year: 2008
    ..Third, we will use the pseudorabies virus as a retrograde tracer to reveal the route and reproducibility of distributed glomerular unit ..
  34. Dual PRV Transsynaptic Labeling: EGFP & mRFP1 Recepters
    Gary E Pickard; Fiscal Year: 2004
    DESCRIPTION (provided by applicant): The transsynaptic retrograde transport of the Bartha strain of pseudorabies virus (PRV Bartha) has become an important neuroanatomical tract-tracing technique for the characterization of neuronal ..
  35. Pathogenesis of pseudorabies virus (PRV):
    Ashley E Reynolds; Fiscal Year: 2008
    ..Public Health Relevance: This Public Health Relevance is not available...
  36. "Pathogenesis of pseudorabies virus (PRV):
    Ashley E Reynolds; Fiscal Year: 2007
    ..We hypothesize that the key viral proteins essential for induction of the host immune and nervous system responses to PRV are glycoprotein E, glycoprotein I and US9 protein...
  37. Mapping Neural Circuits Using Pseudorabie Virus Vectors
    Jeffrey M Friedman; Fiscal Year: 2007
    ..Our groups have recently made a recombinant Pseudorabies virus (PRV) that is conditional on cre-recombinase for viability and expression of a GFP reporter gene...
  38. Mapping Neural Circuits Using Pseudorabie Virus Vectors
    Jeffrey M Friedman; Fiscal Year: 2008
    ..Our groups have recently made a recombinant Pseudorabies virus (PRV) that is conditional on cre-recombinase for viability and expression of a GFP reporter gene...
  39. Dissection of Neuronal Circuits Underlying Obesity
    Shirly Pinto; Fiscal Year: 2004
    ..The proposed aims will be addressed by utilizing a neuronal tracing system, which employs the Pseudorabies virus (PRV) recombinant...

Publications62

  1. Vaccine-induced T cell-mediated immunity plays a critical role in early protection against pseudorabies virus (suid herpes virus type 1) infection in pigs
    E M A van Rooij
    Central Institute for Animal Disease Control, CIDC Lelystad, P O Box 2004, 8203 AA Lelystad, The Netherlands
    Vet Immunol Immunopathol 99:113-25
    ..study was to evaluate the relative importance of antibody and T cell-mediated immunity in protection against pseudorabies virus (suid herpes virus type 1) infection in pigs...
  2. An approach to a FMD vaccine based on genetic engineered attenuated pseudorabies virus: one experiment using VP1 gene alone generates an antibody responds on FMD and pseudorabies in swine
    Ping Qian
    Laboratory of Animal Virology, College of Veterinary Medical Sciences, Huazhong Agricultural University, Wuhan 430070, PR China
    Vaccine 22:2129-36
    Foot-and-mouth disease (FMD) and pseudorabies (PR) are two important infectious diseases in swine. An attenuated pseudorabies virus (PRV) has been successfully used as a gene delivery vector for the development of live-viral vaccines...
  3. A DNA vaccine coding for gB and gD of pseudorabies virus (suid herpes type 1) primes the immune system in the presence of maternal immunity more efficiently than conventional vaccines
    E M A van Rooij
    Central Institute for Animal Disease Control, CIDC Lelystad, P O Box 2004, 8203 AA, Lelystad, The Netherlands
    Vaccine 24:1264-73
    ..To study this, we used the pseudorabies virus (PRV) infection model in the natural host, the pig...
  4. Effect of transgenic expression of porcine interleukin-6 gene and CpG sequences on immune responses of newborn piglets inoculated with Pseudorabies attenuated vaccine
    Zhang Ling Hua
    School of Bioscience and Bioengineering, South China University of Technology, Guangzhou 510640, China
    Res Vet Sci 80:281-6
    ..gene and CpG sequences were used as immunoadjuvants to enhance the immune responses of newborn piglets to Pseudorabies attenuated vaccine (PAV)...
  5. Vaccination with the glycoprotein D gene of pseudorabies virus delivered by nonpathogenic Escherichia coli elicits protective immune responses
    A L Shiau
    Department of Microbiology, National Cheng Kung University Medical College, 701, Tainan, Taiwan
    Vaccine 19:3277-84
    ..The pseudorabies virus (PrV) DNA vaccine carrying the glycoprotein D (gD) gene delivered by E...
  6. Vaccination of pigs with a recombinant porcine adenovirus expressing the gD gene from pseudorabies virus
    J M Hammond
    CSIRO, Livestock Industries, Private Mail Bag 24, Australian Animal Health Laboratory, Geelong, Victoria 3220, Australia
    Vaccine 19:3752-8
    ..either a single dose or two doses of a recombinant porcine adenovirus expressing the glycoprotein D gene from pseudorabies virus (PRV)...
  7. Antibody response of wild boar (Sus scrofa) piglets vaccinated against Aujeszky's disease virus
    F Ruiz-Fons
    Instituto de Investigación en Recursos Cinegéticos IREC (CSIC-UCLM-JCCM, Ronda de Toledo s/n, 13071, Cuidad Real, Spain
    Vet Rec 162:484-5
  8. Immunogenicity of a recombinant pseudorabies virus expressing ORF1-ORF2 fusion protein of porcine circovirus type 2
    Chunmei Ju
    Laboratory of Animal Virology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, PR China
    Vet Microbiol 109:179-90
    Porcine circovirus type 2 (PCV2) is associated with post-weaning multisystemic wasting syndrome (PMWS). Pseudorabies (PR) is also an important infectious disease in swine and sometimes co-infect with PCV2...
  9. An analysis of a presumed major outbreak of pseudorabies virus in a vaccinated sow herd
    A van Nes
    Department of Farm Animal Health, University of Utrecht, The Netherlands
    Epidemiol Infect 126:119-28
    We describe a major outbreak of pseudorabies virus (PRV) in a sow herd in which the sows were vaccinated simultaneously three times a year with a vaccine containing Bartha strain...
  10. The use of different vaccination schedules for sows to protect piglets against Aujeszky's disease
    J Casal
    CReSA, Centre de Recerca en Sanitat Animal, Dep Sanitat i Anatomia Animals, Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    J Vet Med B Infect Dis Vet Public Health 51:8-11
    ..Piglets born from sows vaccinated with attenuated or inactivated vaccines did not present remarkable differences on protection...
  11. Epidemiological survey of viral diseases of pigs in the Mekong delta of Vietnam between 1999 and 2003
    Akemi Kamakawa
    Animal Production and Grassland Division, Japan International Research Center for Agricultural Sciences, 1-1 Ohwashi, Tsukuba, Ibaraki 305-8686, Japan
    Vet Microbiol 118:47-56
    ..identify the causative agent, we first sero-surveyed porcine reproductive and respiratory syndrome (PRRS) and pseudorabies with 478 sera from non-vaccinated pigs collected from backyard farms, state farms and slaughterhouses in Can ..
  12. Protective antiviral immune responses to pseudorabies virus induced by DNA vaccination using dimethyldioctadecylammonium bromide as an adjuvant
    Eugene M A van Rooij
    Central Institute for Animal Disease Control, CIDC Lelystad, PO Box 2004, Houtribweg 39, NL 8203 AA Lelystad, The Netherlands
    J Virol 76:10540-5
    To enhance the efficacy of a DNA vaccine against pseudorabies virus (PRV), we evaluated the adjuvant properties of plasmids coding for gamma interferon or interleukin-12, of CpG immunostimulatory motifs, and of the conventional adjuvants ..
  13. Comparison of immune responses and protective efficacy of suicidal DNA vaccine and conventional DNA vaccine encoding glycoprotein C of pseudorabies virus in mice
    Shaobo Xiao
    Laboratory of Animal Virology, College of Veterinary Medicine, Huazhong Agricultural University, Hubei, Wuhan 430070, PR China
    Vaccine 22:345-51
    ..5) incorporating Semliki Forest virus (SFV) replicon and expressing glycoprotein C (gC) of pseudorabies virus (PrV) was investigated and compared with a conventional plasmid DNA vaccine (pcDC) encoding the same ..
  14. Porcine circovirus type 2-induced interleukin-10 modulates recall antigen responses
    Tuija Kekarainen
    Centre de Recerca en Sanitat Animal, Bellaterra, Barcelona, Spain
    J Gen Virol 89:760-5
    ..Besides alpha and gamma interferon synthesis by PBMCs from pseudorabies virus (PRV)-immunized animals, activated in vitro PRV also was repressed by subsequent infection by PCV2...
  15. Evaluation of efficacy and safety of Aujeszky's disease vaccines
    A Lipowski
    Department of Swine Diseases, National Veterinary Research Institute, Partyzantów 57, 24 100 Puławy, Poland
    Pol J Vet Sci 9:75-9
    ..Soon it became evident that they differ in their efficacy. In this article a panel of tests used for evaluation of safety and efficacy of inactivated as well as live Aujeszky's disease vaccines is described...
  16. Antibodies to selected viral disease agents in wild boars from the Czech Republic
    Kamil Sedlak
    Department of Virology and Serology, State Veterinary Institute Prague, Sidlistni 136 24, 165 03 Prague 6, Czech Republic
    J Wildl Dis 44:777-80
    ..Wild boars in the Czech Republic may act as a potential reservoir of ADV and thus have a role in the epidemiology of this disease...
  17. Effective protection of pigs against lethal Pseudorabies virus infection after a single injection of low-dose Sindbis-derived plasmids encoding PrV gB, gC and gD glycoproteins
    Daniel Dory
    Viral Genetics and Biosafety Unit, AFSSA, BP 53, F 22440 Ploufragan, France
    Vaccine 23:3483-91
    This study compared protection of pigs against lethal Pseudorabies virus (PrV) infection induced by a single injection of various quantities of Sindbis virus-derived plasmids encoding PrV glycoproteins gB, gC and gD...
  18. Risk factors for Aujeszky's-disease seropositivity of swine herds of a region of northern Italy
    M Tamba
    Istituto Zooprofilattico Sperimentale della Lombardia e dell Emilia Romagna, Via Bianchi 9, 25124, Brescia, Italy
    Prev Vet Med 54:203-12
    ..In finishing herds, (1) increased herd size was related to ADV-seropositivity, whereas (2) periodic rearing suspension was protective...
  19. Spatial relative risk mapping of pseudorabies-seropositive pig herds in an animal-dense region
    O Berke
    Department of Biometry, Epidemiology and Information Processing, School of Veterinary Medicine Hannover, Bünteweg 2, D 30559 Hannover, Germany
    J Vet Med B Infect Dis Vet Public Health 50:322-5
    ..The spatial epidemiological analysis is based on geographically referenced data about pseudorabies (Aujeszky's disease) virus infections at farm level in a region of high animal density in Germany at the ..
  20. Specificity of three ELISA-gE kits for screening pig meat for antibodies to Aujeszky's disease
    K De Lange
    Laboratoire OIE de Référence pour la Maladie d'Aujeszky, Ecole National Vétérinaire d'Alfort, 94704 Maisons-Alfort, France
    Vet Rec 153:621-4
    ..995 and 1.000, depending on the classification of the doubtful results. In the case of a positive or doubtful result, it proved useful to repeat the test on the same sample, in order to limit the number of false positive results...
  21. Prime-boost immunization using DNA vaccine and recombinant Orf virus protects pigs against Pseudorabies virus (Herpes suid 1)
    Daniel Dory
    Viral Genetics and Biosafety Unit, French Food Safety Agency Afssa, BP 53, Fr 22440 Ploufragan, France
    Vaccine 24:6256-63
    ..study demonstrates the protective potential of a novel prime-boost vaccination strategy of pigs against lethal Pseudorabies virus (PRV; Herpes suid 1) infection...
  22. In vivo tissue distribution and kinetics of a pseudorabies virus plasmid DNA vaccine after intramuscular injection in swine
    Rodolphe Gravier
    Viral Genetics and Biosafety Unit, French Food Safety Agency, AFSSA, Fr 22440, Ploufragan, France
    Vaccine 25:6930-8
    ..The exact persistence in the injected muscle was not determined but exceeded 4 weeks. To date this is the first published DNA vaccine tissue distribution study in large animals...
  23. Immune and protective abilities of ubiquitinated and non-ubiquitinated pseudorabies virus glycoproteins
    R Gravier
    Viral Genetics and Biosafety Unit, French Food Safety Agency, Ploufragan, France
    Acta Virol 51:35-45
    Plasmids encoding ubiquitinated (ubi-) or non-ubiquitinated (non-ubi-) glycoproteins of Pseudorabies virus (PRV) were used for vaccination of pigs...
  24. Multiple alternating immunizations with DNA vaccine and replication incompetent adenovirus expressing gB of pseudorabies virus protect animals against lethal virus challenge
    Seon Ju Kim
    Laboratory of Microbiology, College of Veterinary Medicine and Bio Safety Research Institute, Chonbuk National University, Jeonju, Korea
    J Microbiol Biotechnol 18:1326-34
    ..with DNA vaccine (pCIgB) and replication-incompetent adenovirus (Ad-gB) expressing glycoprotein gB of pseudorabies virus (PrV)...
  25. Cytokine GM-CSF genetic adjuvant facilitates prophylactic DNA vaccine against pseudorabies virus through enhanced immune responses
    Hyun A Yoon
    Laboratories of Microbiology and College of Veterinary Medicine and Bio-Safety Research Institute, Chonbuk National University, Jeonju, South Korea
    Microbiol Immunol 50:83-92
    ..This study evaluated the utility of GM-CSF cDNA as a DNA vaccine adjuvant for glycoprotein B (gB) of pseudorabies virus (PrV) in a murine model...
  26. Antibody-induced internalization of viral glycoproteins in pseudorabies virus-infected monocytes and role of the cytoskeleton: a confocal study
    Gerlinde R Van De Walle
    Laboratory of Virology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820, Merelbeke, Belgium
    Vet Microbiol 86:51-7
    Addition of pseudorabies virus (PrV)-specific polyclonal immunoglobulins to PrV-infected monocytes induces internalization of plasma membrane anchored viral glycoproteins...
  27. [Sero-monitoring of notifiable diseases in wild boar in the Netherlands 1999-2001]
    A R Elbers
    Gezondheidsdienst voor Dieren, Postbus 9, 7400 AA Deventer
    Tijdschr Diergeneeskd 126:779-81
    ..To date, antibodies against FMD have not been detected...
  28. Immunogenicity and protective efficacy of recombinant pseudorabies virus expressing the two major membrane-associated proteins of porcine reproductive and respiratory syndrome virus
    Yunbo Jiang
    Laboratory of Animal Virology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, Hubei, PR China
    Vaccine 25:547-60
    ..To develop a new generation of vaccine against PRRSV, a live attenuated pseudorabies virus (PRV) was used as vaccine vector to express the two major membrane-associated proteins (GP5 or M) of ..
  29. DNA vaccination against pseudorabies virus and bovine respiratory syncytial virus infections of young animals in the face of maternally derived immunity
    C Hamers
    Merial SAS, Research and Development, Centre de Recherche Saint Vulbas PIPA, Saint Vulbas, France
    J Comp Pathol 137:S35-41
    ..The pseudorabies virus (PRV) infection model in neonatal piglets was employed to demonstrate that a single DNA vaccination was ..
  30. In vivo oral administration effects of various oligodeoxynucleotides containing synthetic immunostimulatory motifs in the immune response to pseudorabies attenuated virus vaccine in newborn piglets
    Zhang Linghua
    Microbiological Staff Room, College of Life Sciences, South China Agricultural University, Wushan Road, Tianhe District, Guangzhou 510642, Guangdong, China
    Vaccine 26:224-33
    ..We have previously demonstrated that human-specific CpG ODN is a potent adjuvant to pseudorabies live attenuated virus (PRV) vaccine when administered subcutaneously (SC) or ocularly in piglets...
  31. Investigation of pseudorabies virus latency in nervous tissues of seropositive pigs exposed to field strain
    Hyun-A Yoon
    Laboratory of Microbiology, College of Veterinary Medicine and Bio-Safety Research Institute, Chonbuk National University, Jeonju 561-756, Republic of Korea
    J Vet Med Sci 68:143-8
    The prevalence and quantity of latent pseudorabies virus (PrV) in nervous tissues of pigs exposed to field strain in Korea was investigated by nested and real-time PCR...
  32. Protective immunity induced by systemic and mucosal delivery of DNA vaccine expressing glycoprotein B of pseudorabies virus
    Hyun A Yoon
    Department of Microbiology, College of Veterinary Medicine and Bio Safety Research Institute, Chonbuk National University, Jeonju 561 756, Korea
    J Microbiol Biotechnol 18:591-9
    ..model immunized by systemic and mucosal delivery of plasmid DNA vaccine expressing glycoprotein B (pCIgB) of pseudorabies virus (PrV) was used to evaluate both the nature of the induced immunity and protection against a virulent ..
  33. Development of real-time polymerase chain reaction assays for rapid detection and differentiation of wild-type pseudorabies and gene-deleted vaccine viruses
    Wenjun Ma
    Department of Veterinary Diagonostic and Production Animal Services, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USA
    J Vet Diagn Invest 20:440-7
    The successful eradication of pseudorabies in U.S. domestic swine was accomplished through the use of glycoprotein E (gE) deleted modified live virus vaccines and an accompanying gE differential enzyme-linked immunosorbent assay (ELISA)...
  34. Survival and immunization of raccoons after exposure to pseudorabies (Aujeszky's disease) virus gene-deleted vaccines
    Ronald M Weigel
    Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Illinois, 2001 South Lincoln Avenue, Urbana, IL 61802, USA
    Vet Microbiol 92:19-24
    In a controlled experiment, 16 wild-trapped raccoons were exposed to 1 of 2 genetically modified live pseudorabies virus (PRV) vaccines used in swine...
  35. Expression of pseudorabies virus gE epitopes in Pichia pastoris and its utilization in an indirect PRV gE-ELISA
    Jing Qun Ao
    State Key Laboratory for Biocontrol, Sun Yat Sen University, Guangzhou 510275, PR China
    J Virol Methods 114:145-50
    b>Pseudorabies virus glycoprotein E (PRV gE) has been recognized as a suitable diagnostic antigen for pseudorabies...
  36. Limited protection conferred by a DNA vaccine against a lethal pseudorabies virus infection at day 5 postvaccination
    Daniel Dory
    Viral Genetics and Biosafety Unit, French Food Safety Agency Afssa, Fr 22440 Ploufragan, France
    Clin Vaccine Immunol 14:470-3
    No pseudorabies virus (PRV)-specific neutralizing or immunoglobulin G1-type antibodies were detected in sera 5 days after injection of a DNA vaccine against PRV infection in pigs...
  37. Receptor-determined susceptibility of preimplantation embryos to pseudorabies virus and porcine reproductive and respiratory syndrome virus
    B Mateusen
    Department of Reproduction, Obstetrics, and Herd Health, Faculty of Veterinary Medicine, Ghent University, 9820 Merelbeke, Belgium
    Biol Reprod 76:415-23
    In the present study, the in vitro interaction of embryos with pseudorabies virus (PRV) and porcine reproductive and respiratory syndrome virus (PRRSV) was investigated by viral antigen detection and by evaluating the expression of virus ..
  38. Comparison of protection levels against pseudorabies virus infection of transgenic mice expressing a soluble form of porcine nectin-1/HveC and vaccinated mice
    Etsuro Ono
    The Avian Zoonoses Research Centre, Faculty of Agriculture, Tottori University, Tottori 680 8533, Japan
    Vet Microbiol 114:327-30
    ..transgenic mice expressing a soluble form of porcine nectin-1 (PHveCIg) showing remarkable resistance to pseudorabies virus (PRV) infection...
  39. A recombinant pseudorabies virus expressing rabies virus glycoprotein: safety and immunogenicity in dogs
    Ziguo Yuan
    Laboratory of Epidemiology, Veterinary Institute, Academy of Military Medical Sciences, 1068 Qinglong Road, Changchun 130062, PR China
    Vaccine 26:1314-21
    ..b>Pseudorabies virus (PRV) has been licensed for use as a live vaccine in pigs and possesses an excellent safety and efficacy ..
  40. Antibody-induced internalization of viral glycoproteins and gE-gI Fc receptor activity protect pseudorabies virus-infected monocytes from efficient complement-mediated lysis
    Gerlinde R Van De Walle
    Laboratory of Virology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B-9820 Merelbeke, Belgium
    J Gen Virol 84:939-48
    b>Pseudorabies virus (PRV)-infected blood monocytes are able to transport virus throughout the body of vaccination-immune pigs...
  41. DNA priming and killed virus boosting vaccination strategy can augment the immune response to pseudorabies virus
    Z H Chen
    College of Veterinary Medicine, China Agricultural University, Beijing, China
    Acta Virol 51:163-70
    The immune efficacy of DNA vaccines containing three plasmids encoding gB, gC, and gD glycoproteins (Mix DNA) of Pseudorabies virus (PRV) or the plasmid for gC only (gC DNA), killed virus (KV) vaccine or combination of gC DNA, Mix DNA and ..
  42. Comparative utility of restriction fragment length polymorphism analysis and gene sequencing to the molecular epidemiological investigation of a viral outbreak
    T L Goldberg
    University of Illinois, Department of Veterinary Pathobiology, Urbana 61820, USA
    Epidemiol Infect 126:415-24
    ..This study compares the application of both techniques to the analysis of 16 pseudorabies virus isolates collected during a 1989 outbreak...
  43. Effects of sugar cane extract on pseudorabies virus challenge of pigs
    Dan-Yuan Lo
    Graduate Institute of Veterinary Pathology, National Chung Hsing University, 402 Taichung, Japan
    J Vet Med Sci 68:219-25
    ..aimed to evaluate the efficacy of sugar cane extract (SCE) on the modulation of porcine immunity against pseudorabies virus (PrV) infection...
  44. Detection of porcine circovirus type 2, porcine parvovirus and porcine pseudorabies virus from pigs with postweaning multisystemic wasting syndrome by multiplex PCR
    S Cao
    Laboratory of Animal Virology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, 430070, PR China
    Vet Res Commun 29:263-9
    Multiplex PCR was established to detect porcine circovirus type 2 (PCV-2), porcine parvovirus (PPV) and porcine pseudorabies virus (PRV) and applied to samples from 137 piglets exhibiting clinical signs of postweaning multisystemic ..
  45. Multiplex PCR for rapid detection of pseudorabies virus, porcine parvovirus and porcine circoviruses
    Chienjin Huang
    Graduate Institute of Veterinary Microbiology, National Chung Hsing University, 250 Kuo Kuang Road, Taichung 40227, Taiwan, ROC
    Vet Microbiol 101:209-14
    ..Specific primers for each of four common DNA viruses, namely, pseudorabies virus (PRV), porcine circovirus type I (PCV1), porcine circovirus type II (PCV2), and porcine parvovirus (PPV), ..
  46. Exploratory spatial analysis of Aujeszky's disease during four phases of the eradication programme in Catalonia, Spain (2003-2007)
    A Allepuz
    Centre de Recerca en Sanitat Animal, UAB IRTA, Campus de la Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain
    Prev Vet Med 86:164-75
    ..40 farms/km(2) (median of 0.28 and standard deviation of 0.33) in clusters of sow farms that became negative and 1.51 (median of 0.70 and standard deviation of 1.61) in clusters where more sow farms became positive (p-value<0.05)...
  47. Temporary inhibition of neuronal apoptosis in Aujeszky's disease virus-infected swine
    A Marcaccini
    Cátedra de Histología II y Embriología Especial, Facultad de Ciencias Veterinarias, Universidad Nacional de Rosario, Casilda, Argentina
    Vet Microbiol 113:237-42
    ....
  48. [Induction or inhibition of apoptosis by pseudorabies virus ea strain in suckling piglets]
    Xiang Min Li
    Laboratory of Animal Virology, College of Animal Medical Science, Huazhong Agricultural University, Wuhan 430070, China
    Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 35:325-30
    To study induction or inhibition of apoptosis by pseudorabies virus (PrV) Ea strain in suckling piglets, Aujeszky s disease was replicated by artificially inoculating 15 day-old piglets with PrV-Ea strain...
  49. Transcriptomic analysis of the dialogue between Pseudorabies virus and porcine epithelial cells during infection
    Laurence Flori
    INRA, DGA, UMR 314, Laboratoire de Radiobiologie et d Etude du Génome, Jouy en Josas, F 78350 France
    BMC Genomics 9:123
    ..b>Pseudorabies virus (PrV), a porcine Alphaherpesvirus, is a good model for such studies in pig...
  50. Molecular survey of latent pseudorabies virus infection in nervous tissues of slaughtered pigs by nested and real-time PCR
    Hyun A Yoon
    Laboratory of Microbiology, College of Veterinary Medicine and Bio-Safety Research Institute, Chonbuk National University, Jeonju 561-756, Republic of Korea
    J Microbiol 43:430-6
    In this study, the prevalence and quantity of a latent pseudorabies virus (PrV) infection in the nervous tissues of randomly selected pigs was determined via nested and real-time PCR...