rheumatic heart disease

Summary

Summary: Cardiac manifestation of systemic rheumatological conditions, such as RHEUMATIC FEVER. Rheumatic heart disease can involve any part the heart, most often the HEART VALVES and the ENDOCARDIUM.

Top Publications

  1. White H, Walsh W, Brown A, Riddell T, Tonkin A, Jeremy R, et al. Rheumatic heart disease in indigenous populations. Heart Lung Circ. 2010;19:273-81 pubmed publisher
    Rates of acute rheumatic fever and chronic rheumatic heart disease in Aboriginal people, Torres Strait Islanders and M?ori continue to be unacceptably high...
  2. Jackson S, Steer A, Campbell H. Systematic Review: Estimation of global burden of non-suppurative sequelae of upper respiratory tract infection: rheumatic fever and post-streptococcal glomerulonephritis. Trop Med Int Health. 2011;16:2-11 pubmed publisher
    To establish the incidence of post-streptococcal glomerulonephritis (PSGN) and acute rheumatic fever, the prevalence of rheumatic heart disease (RHD), and to estimate morbidity and mortality caused by these diseases globally.
  3. Naqshband M, Abid A, Akhtar R, Waheed A, Khan J. Functional tricuspid regurgitation in rheumatic heart disease: surgical options. Ann Thorac Cardiovasc Surg. 2010;16:417-25 pubmed
    ..Patients without significant annular dilatation in the no-repair group improved during follow-up once their left-sided valve lesion was corrected. ..
  4. Aurakzai H, Hameed S, Shahbaz A, Gohar S, Qureshi M, Khan H, et al. Echocardiographic profile of rheumatic heart disease at a tertiary cardiac centre. J Ayub Med Coll Abbottabad. 2009;21:122-6 pubmed
    b>Rheumatic Heart Disease (RHD) continues to be a major public health problem in developing countries like Pakistan...
  5. Ellis N, Kurahara D, Vohra H, Mascaro Blanco A, Erdem G, Adderson E, et al. Priming the immune system for heart disease: a perspective on group A streptococci. J Infect Dis. 2010;202:1059-67 pubmed publisher
  6. Guilherme L, Kalil J. Rheumatic fever and rheumatic heart disease: cellular mechanisms leading autoimmune reactivity and disease. J Clin Immunol. 2010;30:17-23 pubmed publisher
    ..Carditis, the most serious complication, occurs in 30% to 45% of RF patients and leads to chronic rheumatic heart disease (RHD), which is characterized by progressive and permanent valvular lesions...
  7. Kamal H, Hussein G, Hassoba H, Mosaad N, Gad A, Ismail M. Transforming growth factor-beta1 gene C-509T and T869C polymorphisms as possible risk factors in rheumatic heart disease in Egypt. Acta Cardiol. 2010;65:177-83 pubmed
    ..to investigate the possible relationship between the TGF-beta1 gene C-509T and T869C polymorphisms and rheumatic heart disease (RHD), as well as their clinical significance...
  8. Messias Reason I, Schafranski M, Kremsner P, Kun J. Ficolin 2 (FCN2) functional polymorphisms and the risk of rheumatic fever and rheumatic heart disease. Clin Exp Immunol. 2009;157:395-9 pubmed publisher
    ..pyogenes, which is the aetiological agent of rheumatic fever (RF) and its most severe sequelae, chronic rheumatic heart disease (CRHD)...
  9. Parks T, Smeesters P, Steer A. Streptococcal skin infection and rheumatic heart disease. Curr Opin Infect Dis. 2012;25:145-53 pubmed publisher
    ..and there is a growing body of opinion implicating impetigo in the pathogenesis of rheumatic fever and rheumatic heart disease (RHD)...

More Information

Publications62

  1. Geldenhuys A, Koshy J, Human P, Mtwale J, Brink J, Zilla P. Rheumatic mitral repair versus replacement in a threshold country: the impact of commissural fusion. J Heart Valve Dis. 2012;21:424-32 pubmed
    In developing countries rheumatic heart disease is the predominant indication for cardiac surgery. As the disease tends to progress, reoperation rates for mitral valve repairs are high...
  2. Rémond M, Wheaton G, Walsh W, Prior D, Maguire G. Acute rheumatic fever and rheumatic heart disease--priorities in prevention, diagnosis and management. A report of the CSANZ Indigenous Cardiovascular Health Conference, Alice Springs 2011. Heart Lung Circ. 2012;21:632-8 pubmed publisher
    Three priority areas in the prevention, diagnosis and management of acute rheumatic fever (ARF) and rheumatic heart disease (RHD) were identified and discussed in detail: 1...
  3. Marijon E, Celermajer D, Tafflet M, El Haou S, Jani D, Ferreira B, et al. Rheumatic heart disease screening by echocardiography: the inadequacy of World Health Organization criteria for optimizing the diagnosis of subclinical disease. Circulation. 2009;120:663-8 pubmed publisher
    Early case detection is vital in rheumatic heart disease (RHD) in children to minimize the risk of advanced valvular heart disease by preventive measures...
  4. Cilliers A, Manyemba J, Adler A, Saloojee H. Anti-inflammatory treatment for carditis in acute rheumatic fever. Cochrane Database Syst Rev. 2012;:CD003176 pubmed publisher
    b>Rheumatic heart disease remains an important cause of acquired heart disease in developing countries...
  5. Bianchi G, Solinas M, Bevilacqua S, Glauber M. Which patient undergoing mitral valve surgery should also have the tricuspid repair?. Interact Cardiovasc Thorac Surg. 2009;9:1009-20 pubmed publisher
    ..Annuloplasty ring repair has better outcome compared with non-ring based repair techniques; the beneficial effect is also independent of the type of mitral valve surgery performed. ..
  6. Rémond M, Severin K, Hodder Y, Martin J, Nelson C, Atkinson D, et al. Variability in disease burden and management of rheumatic fever and rheumatic heart disease in two regions of tropical Australia. Intern Med J. 2013;43:386-93 pubmed publisher
    Acute rheumatic fever (ARF) and rheumatic heart disease (RHD) contribute to Aboriginal Australian and Torres Strait Islander health disadvantage...
  7. Dobson J, Steer A, Colquhoun S, Kado J. Environmental factors and rheumatic heart disease in Fiji. Pediatr Cardiol. 2012;33:332-6 pubmed publisher
    b>Rheumatic heart disease (RHD) is an important cause of cardiac morbidity and mortality globally, particularly in the Pacific region...
  8. Reményi B, Wilson N, Steer A, Ferreira B, Kado J, Kumar K, et al. World Heart Federation criteria for echocardiographic diagnosis of rheumatic heart disease--an evidence-based guideline. Nat Rev Cardiol. 2012;9:297-309 pubmed publisher
    Over the past 5 years, the advent of echocardiographic screening for rheumatic heart disease (RHD) has revealed a higher RHD burden than previously thought...
  9. Sliwa K, Carrington M, Mayosi B, Zigiriadis E, Mvungi R, Stewart S. Incidence and characteristics of newly diagnosed rheumatic heart disease in urban African adults: insights from the heart of Soweto study. Eur Heart J. 2010;31:719-27 pubmed publisher
    Little is known on the incidence and clinical characteristics of newly diagnosed rheumatic heart disease (RHD) in adulthood from urban African communities in epidemiologic transition...
  10. Steer A, Carapetis J. Acute rheumatic fever and rheumatic heart disease in indigenous populations. Pediatr Clin North Am. 2009;56:1401-19 pubmed publisher
    Acute rheumatic fever and rheumatic heart disease are diseases of socioeconomic disadvantage. These diseases are common in developing countries and in Indigenous populations in industrialized countries...
  11. Tantchou Tchoumi J, Butera G. Rheumatic valvulopathies occurence, pattern and follow-up in rural area: the experience of the Shisong Hospital, Cameroon. Bull Soc Pathol Exot. 2009;102:155-8 pubmed
    b>Rheumatic heart disease (RHD) remains a major public health problem in developing countries. Whereas Africa has 10% of the world's population, broadly as many as half of the 2.4 million children affected by RHD live on the continent...
  12. Otto H, Saether S, Banteyrga L, Haugen B, Skjaerpe T. High prevalence of subclinical rheumatic heart disease in pregnant women in a developing country: an echocardiographic study. Echocardiography. 2011;28:1049-53 pubmed publisher
    Pregnant women with rheumatic heart disease (RHD) carry a high risk of morbidity and mortality. In this study the prevalence of subclinical RHD in pregnant women in Keren, Eritrea was assessed using echocardiography...
  13. Rifaie O, Ismail M, Nammas W. Immediate and long-term outcome of redo percutaneous mitral valvuloplasty: comparison with initial procedure in patients with rheumatic mitral restenosis. J Interv Cardiol. 2010;23:1-6 pubmed publisher
    ..6 +/- 0.3 cm(2). Three patients--out of 12 available for follow-up--developed restenosis. Redo PMV for mitral restenosis is feasible, safe, and achieves immediate and long-term outcome comparable to initial PMV. ..
  14. Kimbally Kaky G, Gombet T, Voumbo Y, Ikama Méo S, Elenga Mbola B, Mbika Cardorelle A, et al. [Rheumatic heart disease in schoolchildren in Brazzaville]. Med Trop (Mars). 2008;68:603-5 pubmed
    The purpose of this study is to screen for rheumatic heart disease as a basis for treatment of the disease and determination of its prevalence in schoolchildren in Brazzaville, Congo...
  15. Ahmad S, Hayat U, Naz H. Frequency of severe mitral stenosis in young female patients having pure mitral stenosis secondary to rheumatic heart disease. J Ayub Med Coll Abbottabad. 2010;22:19-22 pubmed
    High morbidity and mortality due to Rheumatic heart disease (RHD) associated with females is mainly because of late diagnosis on one hand and socioeconomic reasons on the other hand...
  16. Omurzakova N, Yamano Y, Saatova G, Mirzakhanova M, Shukurova S, Kydyralieva R, et al. High incidence of rheumatic fever and rheumatic heart disease in the republics of Central Asia. Int J Rheum Dis. 2009;12:79-83 pubmed publisher
    The epidemiological situation involving rheumatic fever (RF) and rheumatic heart disease (RHD) not only remains unresolved but is also a cause of serious concern due to the rapid increase in the incidence of RF/RHD in many developing ..
  17. Paar J, Berrios N, Rose J, Cáceres M, Peña R, Pérez W, et al. Prevalence of rheumatic heart disease in children and young adults in Nicaragua. Am J Cardiol. 2010;105:1809-14 pubmed publisher
    b>Rheumatic heart disease (RHD) results in morbidity and mortality that is disproportionate among individuals in developing countries compared to those living in economically developed countries...
  18. Karthikeyan G, Mayosi B. Is primary prevention of rheumatic fever the missing link in the control of rheumatic heart disease in Africa?. Circulation. 2009;120:709-13 pubmed publisher
    Rheumatic fever and rheumatic heart disease continue to be major public health problems in the developing world, particularly in the countries of sub-Saharan Africa...
  19. Colquhoun S, Carapetis J, Kado J, Steer A. Rheumatic heart disease and its control in the Pacific. Expert Rev Cardiovasc Ther. 2009;7:1517-24 pubmed publisher
    Rheumatic fever and rheumatic heart disease continue to be a huge public-health burden on many Pacific Island countries...
  20. Roberts K, Colquhoun S, Steer A, Reményi B, Carapetis J. Screening for rheumatic heart disease: current approaches and controversies. Nat Rev Cardiol. 2013;10:49-58 pubmed publisher
    b>Rheumatic heart disease (RHD) is a leading cause of cardiac disease among children in developing nations, and in indigenous populations of some industrialized countries...
  21. Mirabel M, Celermajer D, Ferreira B, Tafflet M, Perier M, Karam N, et al. Screening for rheumatic heart disease: evaluation of a simplified echocardiography-based approach. Eur Heart J Cardiovasc Imaging. 2012;13:1024-9 pubmed publisher
    Portable echocardiography has emerged as a potential tool to detect rheumatic heart disease (RHD) early...
  22. Wilson N. Rheumatic heart disease in indigenous populations--New Zealand experience. Heart Lung Circ. 2010;19:282-8 pubmed publisher
    ..The rates of mitral valve repair for rheumatic heart disease (RHD) are currently greater than 90% in the children's cardiac unit but remain low in adult cardiac units ..
  23. Saikia U, Kumar R, Pandian V, Gupta S, Dhaliwal R, Talwar K. Adhesion molecule expression and ventricular remodeling in chronic rheumatic heart disease: a cause or effect in the disease progression--a pilot study. Cardiovasc Pathol. 2012;21:83-8 pubmed publisher
    Rheumatic fever and chronic rheumatic heart disease (RHD) remains one of the most important causes of cardiovascular morbidity leading to a major public health problem, especially in developing countries...
  24. Bergmark R, Bergmark B, Blander J, Fataki M, Janabi M. Burden of disease and barriers to the diagnosis and treatment of group a beta-hemolytic streptococcal pharyngitis for the prevention of rheumatic heart disease in Dar Es Salaam, Tanzania. Pediatr Infect Dis J. 2010;29:1135-7 pubmed
    To understand patient and clinician attitudes toward Streptococcus pharyngitis and rheumatic heart disease prevention in Tanzania, data from 3 sources were obtained: a survey of 119 clinicians, outpatient rapid test screening, and ..
  25. Saxena A, Ramakrishnan S, Roy A, Seth S, Krishnan A, Misra P, et al. Prevalence and outcome of subclinical rheumatic heart disease in India: the RHEUMATIC (Rheumatic Heart Echo Utilisation and Monitoring Actuarial Trends in Indian Children) study. Heart. 2011;97:2018-22 pubmed publisher
    To study the prevalence and medium term outcome of subclinical rheumatic heart disease (RHD) in India. Cross sectional echocardiographic screening study. School children aged 5-15 years living in rural areas of north India...
  26. Karthikeyan G, Zuhlke L, Engel M, Rangarajan S, Yusuf S, Teo K, et al. Rationale and design of a Global Rheumatic Heart Disease Registry: the REMEDY study. Am Heart J. 2012;163:535-40.e1 pubmed publisher
    b>Rheumatic heart disease (RHD) is the principal cause of valvular heart disease-related mortality and morbidity in low- and middle-income countries. The disease predominantly affects children and young adults...
  27. Beaton A, Okello E, Lwabi P, Mondo C, McCarter R, Sable C. Echocardiography screening for rheumatic heart disease in Ugandan schoolchildren. Circulation. 2012;125:3127-32 pubmed publisher
    Historically, sub-Saharan Africa has had the highest prevalence rates of clinically detected rheumatic heart disease (RHD). Echocardiography-based screening improves detection of RHD in endemic regions...
  28. Bhaya M, Panwar S, Beniwal R, Panwar R. High prevalence of rheumatic heart disease detected by echocardiography in school children. Echocardiography. 2010;27:448-53 pubmed publisher
    It is fairly easy to detect advanced valve lesions of established rheumatic heart disease by echocardiography in the clinically identified cases of rheumatic heart disease...
  29. Duzgun N, Duman T, Haydardedeoglu F, Tutkak H. Cytotoxic T lymphocyte-associated antigen-4 polymorphism in patients with rheumatic heart disease. Tissue Antigens. 2009;74:539-42 pubmed publisher
    ..of the infectious organism leads to the development of autoimmune reactions and cardiac tissue damage in rheumatic heart disease (RHD)...
  30. Rehman S, Akhtar N, Saba N, Munir S, Ahmed W, Mohyuddin A, et al. A study on the association of TNF-?(-308), IL-6(-174), IL-10(-1082) and IL-1Ra(VNTR) gene polymorphisms with rheumatic heart disease in Pakistani patients. Cytokine. 2013;61:527-31 pubmed publisher
    Inflammation is an important contributor to the pathogenesis of rheumatic heart disease (RHD), a disorder of heart valves caused by a combination of immune, genetic and environmental factors...
  31. Reményi B, Carapetis J, Wyber R, Taubert K, Mayosi B. Position statement of the World Heart Federation on the prevention and control of rheumatic heart disease. Nat Rev Cardiol. 2013;10:284-92 pubmed publisher
    In the 21(st) century, rheumatic fever (RF) and rheumatic heart disease (RHD) are neglected diseases of marginalized communities. Globally, RHD remains the most-common cardiovascular disease in young people aged <25 years...
  32. Zuhlke L, Mirabel M, Marijon E. Congenital heart disease and rheumatic heart disease in Africa: recent advances and current priorities. Heart. 2013;99:1554-61 pubmed publisher
    ..prevalence of heart diseases in children and young adults, including congenital heart disease (CHD) and rheumatic heart disease (RHD)...
  33. Manji R, Witt J, Tappia P, Jung Y, Menkis A, Ramjiawan B. Cost-effectiveness analysis of rheumatic heart disease prevention strategies. Expert Rev Pharmacoecon Outcomes Res. 2013;13:715-24 pubmed publisher
    b>Rheumatic heart disease (RHD), secondary to group A streptococcal infection is endemic in the developing as well as parts of the developed world with significant costs to the patient, and to the healthcare system...
  34. Tantchou Tchoumi J, Ambassa J, Kingue S, Giamberti A, Cirri S, Frigiola A, et al. Occurrence, aetiology and challenges in the management of congestive heart failure in sub-Saharan Africa: experience of the Cardiac Centre in Shisong, Cameroon. Pan Afr Med J. 2011;8:11 pubmed
    ..The compensation treatment of congestive heart failure is challenging in our milieu, characterized by poor compliance and financial limitations. ..
  35. Alizzi A, Knight J, Tully P. Surgical challenges in rheumatic heart disease in the Australian indigenous population. Heart Lung Circ. 2010;19:295-8 pubmed publisher
    Acute rheumatic fever, leading to rheumatic heart disease (RHD), is rare in Australia except amongst Aboriginal and Torres Strait Islander people...
  36. Ciss A, Diarra O, Dieng P, N Diaye A, Ba P, Toure A, et al. [Mitral valve repair for rheumatic valve disease in children in Senegal: a review of 100 cases]. Med Trop (Mars). 2009;69:278-80 pubmed
    ..4% (p = 0.99). Mitral valve repair was successful in stabilizing myocardial function and remodeling the left ventricle. Outcome is dependent on careful patient selection and evaluation of lesions. Middle-term outcome is encouraging. ..
  37. Baskerville C, Hanrahan B, Burke A, Holwell A, Rémond M, Maguire G. Infective endocarditis and rheumatic heart disease in the north of Australia. Heart Lung Circ. 2012;21:36-41 pubmed publisher
    ..IE), Australian guidelines recommend providing prophylactic antibiotics to Indigenous patients with rheumatic heart disease (RHD) prior to procedures which may cause bacteremia. In northern Australia RHD remains prevalent...
  38. Zuhlke L, Mayosi B. Echocardiographic screening for subclinical rheumatic heart disease remains a research tool pending studies of impact on prognosis. Curr Cardiol Rep. 2013;15:343 pubmed publisher
    ..The application of portable echocardiography to the screening of asymptomatic children and young adults for rheumatic heart disease (RHD) in developing countries indicates that the disease may affect 62 million to 78 million individuals ..
  39. Irlam J, Mayosi B, Engel M, Gaziano T. Primary prevention of acute rheumatic fever and rheumatic heart disease with penicillin in South African children with pharyngitis: a cost-effectiveness analysis. Circ Cardiovasc Qual Outcomes. 2013;6:343-51 pubmed publisher
    Acute rheumatic fever and subsequent rheumatic heart disease remain significant in developing countries...
  40. Okello E, Wanzhu Z, Musoke C, Twalib A, Kakande B, Lwabi P, et al. Cardiovascular complications in newly diagnosed rheumatic heart disease patients at Mulago Hospital, Uganda. Cardiovasc J Afr. 2013;24:80-5 pubmed publisher
    Complications of rheumatic heart disease are associated with severe morbidity and mortality in developing countries where the disease prevalence remains high...
  41. Onwuchekwa A, Asekomeh G. Pattern of heart failure in a Nigerian teaching hospital. Vasc Health Risk Manag. 2009;5:745-50 pubmed
    ..The commonest causes of CCF were hypertension (56.3%) and cardiomyopathy (12.3%). Chronic renal failure, rheumatic heart disease, and ischemic heart disease accounted for 7.8%, 4.3%, and 0.2% of CCF, respectively...
  42. Mocumbi A. The challenges of cardiac surgery for African children. Cardiovasc J Afr. 2012;23:165-7 pubmed publisher
  43. Diao M, Kane A, Ndiaye M, Mbaye A, Bodian M, Dia M, et al. Pregnancy in women with heart disease in sub-Saharan Africa. Arch Cardiovasc Dis. 2011;104:370-4 pubmed publisher
    ..Although previous studies showed that pregnancy with heart disease is associated with significant complications, few focused on patients with valvular heart disease in sub-Saharan Africa...
  44. Marijon E, Mirabel M, Celermajer D, Jouven X. Rheumatic heart disease. Lancet. 2012;379:953-964 pubmed publisher
    b>Rheumatic heart disease, often neglected by media and policy makers, is a major burden in developing countries where it causes most of the cardiovascular morbidity and mortality in young people, leading to about 250,000 deaths per year ..
  45. Bhardwaj R, Kandoria A, Marwah R, Vaidya P, Singh B, Dhiman P, et al. Prevalence of rheumatic fever and rheumatic heart disease in rural population of Himachal--a population based study. J Assoc Physicians India. 2012;60:13-4 pubmed
    b>Rheumatic heart disease is still the commonest valvular heart disease in India. There is no population based study regarding the prevalence of rheumatic fever/rheumatic heart disease (RF/RHD) from Himachal and hence the purpose of study.
  46. Suliman A. The state of heart disease in Sudan. Cardiovasc J Afr. 2011;22:191-6 pubmed publisher
    ..The SHHS reported a prevalence of 2.5% for heart disease. Hypertensive heart disease (HHD), rheumatic heart disease (RHD), ischaemic heart disease (IHD) and cardiomyopathy constitute more than 80% of CVD in Sudan...
  47. Guilherme L, Cury P, Demarchi L, Coelho V, Abel L, Lopez A, et al. Rheumatic heart disease: proinflammatory cytokines play a role in the progression and maintenance of valvular lesions. Am J Pathol. 2004;165:1583-91 pubmed
    Heart lesions of rheumatic heart disease (RHD) patients contain T-cell clones that recognize heart proteins and streptococcal M peptides...
  48. Ravisha M, Tullu M, Kamat J. Rheumatic fever and rheumatic heart disease: clinical profile of 550 cases in India. Arch Med Res. 2003;34:382-7 pubmed
    ..of this paper were to analyze the clinical presentation of children with rheumatic fever (RF) and rheumatic heart disease (RHD), to determine the cardiac sequel of RF and valvular affection due to RF, and to study clinical ..
  49. Sampath Kumar A, Talwar S, Saxena A, Singh R. Ross procedure in rheumatic aortic valve disease. Eur J Cardiothorac Surg. 2006;29:156-61 pubmed
    To assess the results of aortic valve replacement with the pulmonary autograft in patients with rheumatic heart disease. From October 1993 through September 2003, 81 rheumatic patients with aortic valve disease, mean age 29.5+/-11...
  50. Robertson K, Volmink J, Mayosi B. Towards a uniform plan for the control of rheumatic fever and rheumatic heart disease in Africa--the Awareness Surveillance Advocacy Prevention (A.S.A.P.) Programme. S Afr Med J. 2006;96:241 pubmed
  51. Marijon E, Ou P, Celermajer D, Ferreira B, Mocumbi A, Jani D, et al. Prevalence of rheumatic heart disease detected by echocardiographic screening. N Engl J Med. 2007;357:470-6 pubmed
    Epidemiologic studies of the prevalence of rheumatic heart disease have used clinical screening with echocardiographic confirmation of suspected cases...
  52. Sani M, Karaye K, Borodo M. Prevalence and pattern of rheumatic heart disease in the Nigerian savannah: an echocardiographic study. Cardiovasc J Afr. 2007;18:295-9 pubmed
    b>Rheumatic heart disease (RHD) remains a major public health problem in developing countries. Whereas Africa has 10% of the world's population, as many as half of the 2.4 million children affected by RHD globally live on the continent...
  53. Saxena A, Kumar R, Gera R, Radhakrishnan S, Mishra S, Ahmed Z. Consensus guidelines on pediatric acute rheumatic fever and rheumatic heart disease. Indian Pediatr. 2008;45:565-73 pubmed
    ..Furthermore, there are glaring differences in management protocols available in literature. These facts prompted Indian Academy of Pediatrics to review the management of rheumatic fever...