legionellosis

Summary

Summary: Infections with bacteria of the genus LEGIONELLA.

Top Publications

  1. Kulkarni K, Thorat S, Wagle S, Khadilkar S. Focal neurological manifestations in Legionellosis. J Assoc Physicians India. 2005;53:731-3 pubmed
    ..Neurological involvement in legionellosis is rare and tends to be among the presenting manifestations...
  2. Fisman D, Lim S, Wellenius G, Johnson C, Britz P, Gaskins M, et al. It's not the heat, it's the humidity: wet weather increases legionellosis risk in the greater Philadelphia metropolitan area. J Infect Dis. 2005;192:2066-73 pubmed
    ..Increases in cases of community-acquired legionellosis in the greater Philadelphia metropolitan area (GPMA) led to concern that changing environmental factors could ..
  3. Doyle R, Cianciotto N, Banvi S, Manning P, Heuzenroeder M. Comparison of virulence of Legionella longbeachae strains in guinea pigs and U937 macrophage-like cells. Infect Immun. 2001;69:5335-44 pubmed
    A guinea pig model of experimental legionellosis was established for assessment of virulence of isolates of Legionella longbeachae. The results showed that there were distinct virulence groupings of L...
  4. Borella P, Montagna M, Romano Spica V, Stampi S, Stancanelli G, Triassi M, et al. [Environmental diffusion of Legionella spp and legionellosis frequency among patients with pneumonia: preliminary results of a multicentric Italian survey]. Ann Ig. 2003;15:493-503 pubmed
    ..goal of the research plan is to account for some critical aspects concerning identification and prevention of legionellosis. To improve knowledge on factors associated with Legionella spp colonisation in hot waters, to detect cases ..
  5. Fields B, Nerad T, Sawyer T, King C, Barbaree J, Martin W, et al. Characterization of an axenic strain of Hartmannella vermiformis obtained from an investigation of nosocomial legionellosis. J Protozool. 1990;37:581-3 pubmed
    ..as Hartmannella vermiformis was isolated from a water sample obtained during an investigation of nosocomial legionellosis. Hartmannella vermiformis is known to support the intracellular multiplication of Legionella pneumophila...
  6. Alvarez J, Oyaga N, Escofet A, Codony F, Orcau A, Maria Oliva J. [Community-acquired legionellosis in the Barcelona region between 1992 and 1999: epidemiological characteristics and diagnostic methods]. Med Clin (Barc). 2001;117:495-6 pubmed
    The epidemiological characteristics of community-acquired legionellosis are not well known. We present here legionellosis cases appearing in Barcelona, Spain, districts during 1992-1999.
  7. Dirven K, Ieven M, Peeters M, van der Zee A, De Schrijver K, Goossens H. Comparison of three Legionella urinary antigen assays during an outbreak of legionellosis in Belgium. J Med Microbiol. 2005;54:1213-6 pubmed
    During an outbreak of legionellosis in Belgium, urine samples of 32 legionellosis patients were tested with three Legionella urinary antigen assays: the Biotest enzyme immunoassay (EIA) kit, the Binax EIA kit and the Binax NOW ..
  8. La Scola B, Mezi L, Weiller P, Raoult D. Isolation of Legionella anisa using an amoebic coculture procedure. J Clin Microbiol. 2001;39:365-6 pubmed
    Conventional diagnostic tests for legionellosis were negative for a 61-year-old immunocompromised man with pneumonia. However, coculture of a sputum sample with Acanthamoeba polyphaga amoebae led to the recovery of Legionella anisa...
  9. Borella P, Montagna M, Romano Spica V, Stampi S, Stancanelli G, Triassi M, et al. Legionella infection risk from domestic hot water. Emerg Infect Dis. 2004;10:457-64 pubmed

More Information

Publications65

  1. Saint C, Ho L. A PCR test for the identification and discrimination of Legionella longbeachae serogroups 1 and 2. J Microbiol Methods. 1999;37:245-53 pubmed
    ..PCR testing was demonstrated as a superior method of identification to traditional seroagglutination reactions, which were ambiguous and could explain the previous failure to identify the presence of this microorganism in water...
  2. Makin T, Pride M. Venturi system could be major breakthrough. Health Estate. 2010;64:27-33 pubmed
  3. Kubota M, Tomii K, Tachikawa R, Harada Y, Seo R, Kaji R, et al. [Legionella longbeachae pneumonia infection from home garden soil]. Nihon Kokyuki Gakkai Zasshi. 2007;45:698-703 pubmed
    ..rapidly subsided with the initiation of Ciprofloxacin and his sputum culture on GVPC medium indicated Legionellosis, which was afterwards identified as L. longbeachae by PCR and DNA-DNA hybridization...
  4. Kroca M, Johansson A, Sjostedt A, Tarnvik A. V gamma 9V delta 2 T cells in human legionellosis. Clin Diagn Lab Immunol. 2001;8:949-54 pubmed
    ..The assumption was tested here on legionellosis, a condition conforming to the category but not yet described with respect to gammadelta T cells...
  5. Napoli C, Fasano F, Iatta R, Barbuti G, Cuna T, Montagna M. Legionella spp. and legionellosis in southeastern Italy: disease epidemiology and environmental surveillance in community and health care facilities. BMC Public Health. 2010;10:660 pubmed publisher
    Following the publication of the Italian Guidelines for the control and prevention of legionellosis an environmental and clinical surveillance has been carried out in Southeastern Italy...
  6. Kappstein I. [Water filter for prevention of nosocomial legionellosis?]. Dtsch Med Wochenschr. 2006;131:2789-92 pubmed
  7. Anaissie E, Penzak S, Dignani M. The hospital water supply as a source of nosocomial infections: a plea for action. Arch Intern Med. 2002;162:1483-92 pubmed
    ..The purpose of this review is to assess the magnitude of the problem caused by waterborne nosocomial infections and to plea for immediate action for their prevention...
  8. Brieland J, McClain M, Legendre M, Engleberg C. Intrapulmonary Hartmannella vermiformis: a potential niche for Legionella pneumophila replication in a murine model of legionellosis. Infect Immun. 1997;65:4892-6 pubmed
    ..vermiformis and support the hypothesis that inhaled amoebae may potentiate intrapulmonary growth of L. pneumophila by providing a niche for bacterial replication...
  9. O NEILL E, Humphreys H. Surveillance of hospital water and primary prevention of nosocomial legionellosis: what is the evidence?. J Hosp Infect. 2005;59:273-9 pubmed
    ..controversy about the relationship between the presence of legionella in hospital water systems and nosocomial legionellosis. Primary prevention, i.e...
  10. Goh K, Ng D, Yap J, Ma S, Ooi E. Surveillance, prevention, and control of legionellosis in a tropical city-state. Am J Infect Control. 2005;33:286-91 pubmed
    b>Legionellosis is endemic in Singapore, with sporadic cases reported throughout the year...
  11. Montagna M, Napoli C, Tatò D, Spilotros G, Como D, Barbuti S. [Legionellosis in Apulia (Italy): an underevaluated disease]. Ann Ig. 2005;17:3-9 pubmed
    ..Thirty-seven patients (6%) tested positive for legionellosis: 10 resulted nosocomial cases and 27 as community-acquired...
  12. O Connor B, Carman J, Eckert K, Tucker G, Givney R, Cameron S. Does using potting mix make you sick? Results from a Legionella longbeachae case-control study in South Australia. Epidemiol Infect. 2007;135:34-9 pubmed
    ..Results are consistent with inhalation and ingestion as possible modes of transmission. Exposure to aerosolized organisms and poor gardening hygiene may be important predisposing factors to L. longbeachae infection...
  13. Thurman K, Warner A, Cowart K, Benitez A, Winchell J. Detection of Mycoplasma pneumoniae, Chlamydia pneumoniae, and Legionella spp. in clinical specimens using a single-tube multiplex real-time PCR assay. Diagn Microbiol Infect Dis. 2011;70:1-9 pubmed publisher
    ..This procedure may allow for a practical and efficient means to test respiratory clinical specimens for atypical pneumonia agents in health care settings and facilitate an appropriate public health response to outbreaks...
  14. Phares C, Wangroongsarb P, Chantra S, Paveenkitiporn W, Tondella M, Benson R, et al. Epidemiology of severe pneumonia caused by Legionella longbeachae, Mycoplasma pneumoniae, and Chlamydia pneumoniae: 1-year, population-based surveillance for severe pneumonia in Thailand. Clin Infect Dis. 2007;45:e147-55 pubmed publisher
    ..Legionella species, Mycoplasma pneumoniae, and Chlamydia pneumoniae are recognized as important causes of pneumonia in high-income countries, but their significance in middle-income countries, such as Thailand, is unknown...
  15. Pravinkumar S, Edwards G, Lindsay D, Redmond S, Stirling J, House R, et al. A cluster of Legionnaires' disease caused by Legionella longbeachae linked to potting compost in Scotland, 2008-2009. Euro Surveill. 2010;15:19496 pubmed
    ..The linked cases associated with compost exposure call for an introduction of compost labelling, as is already in place in other countries where L. longbeachae outbreaks have been reported...
  16. Neil K, Berkelman R. Increasing incidence of legionellosis in the United States, 1990-2005: changing epidemiologic trends. Clin Infect Dis. 2008;47:591-9 pubmed publisher
    An abrupt increase in the incidence of legionellosis in the United States has been noted since 2003. Whether the recent increase is associated with shifting epidemiologic trends has not been well characterized.
  17. Kuroki T, Ishihara T, Ito K, Kura F. Bathwater-associated cases of legionellosis in Japan, with a special focus on Legionella concentrations in water. Jpn J Infect Dis. 2009;62:201-5 pubmed
    To evaluate the relationship between the incidence of legionellosis and Legionella concentrations in bathwater, we sent a questionnaire to 76 prefectural and municipal public health laboratories in Japan and found that 35 had encountered ..
  18. Bennett E, Ashton M, Calvert N, Chaloner J, Cheesbrough J, Egan J, et al. Barrow-in-Furness: a large community legionellosis outbreak in the UK. Epidemiol Infect. 2014;142:1763-77 pubmed publisher
    A community outbreak of legionellosis occurred in Barrow-in-Furness, Cumbria, during July and August 2002...
  19. Garcia C, Ugalde E, Campo A, Minambres E, Kovacs N. Fatal case of community-acquired pneumonia caused by Legionella longbeachae in a patient with systemic lupus erythematosus. Eur J Clin Microbiol Infect Dis. 2004;23:116-8 pubmed
    ..including urinary antigen and serology, cannot detect infections caused by non- pneumophila Legionella spp., culture on legionella-selective media should be strongly considered when diagnosing immunosuppressed patients with pneumonia...
  20. Fields B, Haupt T, Davis J, Arduino M, Miller P, Butler J. Pontiac fever due to Legionella micdadei from a whirlpool spa: possible role of bacterial endotoxin. J Infect Dis. 2001;184:1289-92 pubmed
    ..Additional studies are needed to determine the role of endotoxin from legionellae or other bacteria in the pathogenesis of Pontiac fever...
  21. Bangsborg J, Friis Møller A, Rechnitzer C, Høiby N, Lind K. The E. coli immunosorbent as used in serodiagnosis of Legionella infections studied by crossed immunoelectrophoresis. APMIS. 1988;96:177-84 pubmed
    ..CIE results could not explain the effect of BF in Legionella IFA, and further studies are needed to sufficiently define the use of immunosorbents in diagnostic Legionella serology...
  22. Levin A. Nosocomial legionellosis: prevention and management. Expert Rev Anti Infect Ther. 2009;7:57-68 pubmed publisher
    ..No randomized controlled trials have been performed to study the treatment of legionellosis but comparative observational studies have been published, mostly involving community-acquired cases...
  23. Li J, O Brien E, Guest C. A review of national legionellosis surveillance in Australia, 1991 to 2000. Commun Dis Intell Q Rep. 2002;26:461-8 pubmed
    A study was undertaken to analyse legionellosis notifications for the period 1991 to 2000 to establish the distribution of legionellosis in Australia with the aim of identifying risk factors amenable to public health intervention...
  24. Montagna M, Napoli C, Tatò D, Spilotros G, Barbuti G, Barbuti S. Clinical-environmental surveillance of legionellosis: an experience in Southern Italy. Eur J Epidemiol. 2006;21:325-31 pubmed
    In Italy, although the number of cases of legionellosis notified to the health authorities has significantly increased in recent years, the incidence is still believed to be underestimated...
  25. Rangel K, Delclos G, Emery R, Symanski E. Assessing maintenance of evaporative cooling systems in legionellosis outbreaks. J Occup Environ Hyg. 2011;8:249-65 pubmed publisher
  26. Su H, Tseng L, Tzeng S, Chou C, Chung T. A legionellosis case due to contaminated spa water and confirmed by genomic identification in Taiwan. Microbiol Immunol. 2006;50:371-7 pubmed
    Tracing the source of a legionellosis (LG) case revealed that the Legionella pneumophila (LP) strain isolated from patient's sputum shared the same serogroup (SG) and PFGE-type with 4 LP strains obtained from a spa center...
  27. Descours G, Suet A, Ginevra C, Campese C, Slimani S, Ader F, et al. Contribution of amoebic coculture to recovery of Legionella isolates from respiratory samples: prospective analysis over a period of 32 months. J Clin Microbiol. 2012;50:1725-6 pubmed publisher
    ..1%. Amoebic coculture was particularly efficient in isolating Legionella spp. from respiratory samples contaminated with oropharyngeal flora...
  28. Guyard C, Low D. Legionella infections and travel associated legionellosis. Travel Med Infect Dis. 2011;9:176-86 pubmed publisher
    ..Because of the propensity of these bacteria to colonize man-made water systems, legionellosis are frequently reported in travelers who stayed in accommodations sites such as hotels or cruise ships...
  29. Rantakokko Jalava K, Jalava J. Development of conventional and real-time PCR assays for detection of Legionella DNA in respiratory specimens. J Clin Microbiol. 2001;39:2904-10 pubmed
  30. Yu V, Plouffe J, Pastoris M, Stout J, Schousboe M, Widmer A, et al. Distribution of Legionella species and serogroups isolated by culture in patients with sporadic community-acquired legionellosis: an international collaborative survey. J Infect Dis. 2002;186:127-8 pubmed
    This international collaborative survey identified culture-confirmed legionellosis in 508 patients with sporadic community-acquired legionellosis. Legionella pneumophila constituted 91.5% of the isolates...
  31. Pancer K, Stypułkowska Misiurewicz H. [Pontiac fever--non-pneumonic legionellosis]. Przegl Epidemiol. 2003;57:607-12 pubmed
    Pontiac fever is a non-pneumonic, epidemic form of legionellosis. The symptoms are similar to flu: fever, tiredness, myalgia, arthralgia, headache, cough, sore throat and nausea. The incubation period is from 30 to 90 hours, approx. 36 h...
  32. Jespersen S, Søgaard O, Schønheyder H, Fine M, Ostergaard L. Clinical features and predictors of mortality in admitted patients with community- and hospital-acquired legionellosis: a Danish historical cohort study. BMC Infect Dis. 2010;10:124 pubmed publisher
    Legionella is a common cause of bacterial pneumonia. Community-acquired [CAL] and hospital-acquired legionellosis [HAL] may have different presentations and outcome...
  33. Muder R, Yu V. Infection due to Legionella species other than L. pneumophila. Clin Infect Dis. 2002;35:990-8 pubmed
    ..The major clinical manifestation of infection due to Legionella species is pneumonia, although nonpneumonic legionellosis (Pontiac fever) and extrapulmonary infection may occur...
  34. Napoli C, Tatò D, Iatta R, Montagna M. [Assessment of occupational risk of Legionella spp. infection among dental health-care personnel]. Ig Sanita Pubbl. 2007;63:683-9 pubmed
    ..It is essential, therefore, that surveillance of microbiological quality of dental waterlines be implemented and appropriate disinfection procedures performed where necessary...
  35. Atlas R. Legionella: from environmental habitats to disease pathology, detection and control. Environ Microbiol. 1999;1:283-93 pubmed
    Studies on Legionella show a continuum from environment to human disease. Legionellosis is caused by Legionella species acquired from environmental sources, principally water sources such as cooling towers, where Legionella grows ..
  36. Borella P, Bargellini A, Marchesi I, Rovesti S, Stancanelli G, Scaltriti S, et al. Prevalence of anti-legionella antibodies among Italian hospital workers. J Hosp Infect. 2008;69:148-55 pubmed publisher
    ..No association was found between the presence of antibodies and the presence of risk factors for legionellosis, nor with the occurrence of pneumonia and/or flu-like symptoms...
  37. Trerotoli P, Montagna M, Borella P, Romano Spica V, Stancanelli G, Triassi M, et al. [The discharge form: advantages and limits legionellosis cases individuation]. Ann Ig. 2003;15:817-24 pubmed
    Despite legionellosis surveillance is active in Italy since many years, the disease notification appears still undervalued. A multicentric survey was carried out among 5 big Italian hospitals...
  38. Maurin M, Hammer L, Gestin B, Timsit J, Rogeaux O, Delavena F, et al. Quantitative real-time PCR tests for diagnostic and prognostic purposes in cases of legionellosis. Clin Microbiol Infect. 2010;16:379-84 pubmed publisher
    ..6, 98.7, 77.7 and 97.4%, respectively. Group B included 56 consecutive legionellosis patients diagnosed during a 4-year period (2003-2006) at the Grenoble University Hospital...
  39. Ditommaso S, Biasin C, Giacomuzzi M, Zotti C, Arione R, Guglielmi E, et al. Colonization of a water system by Legionella organisms and nosocomial legionellosis: a 5-year report from a large Italian hospital. Infect Control Hosp Epidemiol. 2006;27:532-5 pubmed
  40. Boivin S, Lacombe M, Lalancette L, Allard A, Bordeleau M, Laverdure G. Environmental factors associated with nosocomial legionellosis after anti-tumor necrosis factor therapy: case study. Am J Infect Control. 2012;40:470-3 pubmed publisher
    In response to 2 reported cases of nosocomial legionellosis after anti-tumor necrosis factor (TNF) treatment, the environmental controls and testing facilities in a 221-bed acute care hospital were investigated...
  41. Whiley H, Bentham R. Legionella longbeachae and legionellosis. Emerg Infect Dis. 2011;17:579-83 pubmed publisher
    Reported cases of legionellosis attributable to Legionella longbeachae infection have increased worldwide. In Australia and New Zealand, L. longbeachae has been a known cause of legionellosis since the late 1980s...
  42. Ng V, Tang P, Jamieson F, Guyard C, Low D, Fisman D. Laboratory-based evaluation of legionellosis epidemiology in Ontario, Canada, 1978 to 2006. BMC Infect Dis. 2009;9:68 pubmed publisher
    b>Legionellosis is a common cause of severe community acquired pneumonia and respiratory disease outbreaks...
  43. Kümpers P, Tiede A, Kirschner P, Girke J, Ganser A, Peest D. Legionnaires' disease in immunocompromised patients: a case report of Legionella longbeachae pneumonia and review of the literature. J Med Microbiol. 2008;57:384-7 pubmed publisher
    ..The features of Legionnaires' disease in immunocompromised patients with special emphasis on significance and detection of non-pneumophila species are reviewed...
  44. Hicks L, Rose C, Fields B, Drees M, Engel J, Jenkins P, et al. Increased rainfall is associated with increased risk for legionellosis. Epidemiol Infect. 2007;135:811-7 pubmed
    ..To investigate a possible relationship, we analysed the association between monthly legionellosis incidence and monthly rainfall totals from January 1990 to December 2003 in five Mid-Atlantic states...
  45. Diederen B, van Zwet A, van der Zee A, Peeters M. Community-acquired pneumonia caused by Legionella longbeachae in an immunocompetent patient. Eur J Clin Microbiol Infect Dis. 2005;24:545-8 pubmed
    ..cannot detect infections caused by non-pneumophila Legionella spp., culture on Legionella-selective media or PCR should be considered when diagnosing severe pneumonia of unknown etiology...
  46. Shimada T, Noguchi Y, Jackson J, Miyashita J, Hayashino Y, Kamiya T, et al. Systematic review and metaanalysis: urinary antigen tests for Legionellosis. Chest. 2009;136:1576-1585 pubmed publisher
    ..Urinary antigen assays offer simplicity and rapidity in diagnosing Legionnaires' disease, though studies report a range of sensitivities. We conducted a systematic review to assess the test characteristics of Legionella urinary antigen...
  47. Gilmour M, Bernard K, Tracz D, Olson A, Corbett C, Burdz T, et al. Molecular typing of a Legionella pneumophila outbreak in Ontario, Canada. J Med Microbiol. 2007;56:336-41 pubmed
    ..These molecular typing methods confirmed the outbreak source as a contaminated air conditioning cooling tower...
  48. Brewster U. Acute renal failure associated with legionellosis. Ann Intern Med. 2004;140:406-7 pubmed
  49. Heudorf U, Hentschel W, Hoffmann M, Luck C, Schubert R. [Legionellas in domestic warm water--effects on the health of residents]. Gesundheitswesen. 2001;63:326-34 pubmed
    ..During this investigation in the population exposed to Legionella no cases of legionellosis were reported...
  50. Lowry P, Tompkins L. Nosocomial legionellosis: a review of pulmonary and extrapulmonary syndromes. Am J Infect Control. 1993;21:21-7 pubmed
    ..We describe 22 cases of extrapulmonary legionellosis reported in the literature...
  51. Stypułkowska Misiurewicz H, Pancer K. [Legionellosis in Poland in 2005]. Przegl Epidemiol. 2007;61:235-8 pubmed
    b>Legionellosis is a notified disease in Poland since 2001, but laboratory diagnostic methods were introduced even earlier, in 1997. In 2005 the 21 cases of legionellosis were reported in Poland, the incidence rate was 0.055 /100,000...
  52. Lay C, Yu K, Chi C, Lai C, Wong W, Liu C. Impact of the 1997 revised Centers for Disease Control criteria on case rates of legionellosis in Taiwan: review of 38 cases at a teaching hospital, 1998-2002. J Microbiol Immunol Infect. 2005;38:211-7 pubmed
    ..the United States Centers for Disease Control and Prevention (CDC) published revised case definitions for legionellosis which eliminated the previously used category of "probable case" based on a single indirect ..
  53. Shroff G, Marom E, Wu C, Godoy M, Wei W, Ihegword A, et al. Pulmonary Legionellosis in Oncologic Patients: Findings on Chest CT. J Comput Assist Tomogr. 2016;40:917-922 pubmed
    ..pneumophila and non-pneumophila Legionella. Findings in L. pneumophila pneumonia and non-pneumophila Legionella pneumonia are similar but nonspecific. Airspace consolidation is almost always present; the halo sign is not uncommon. ..
  54. Zhang C, Kuspa A. Transcriptional down-regulation and rRNA cleavage in Dictyostelium discoideum mitochondria during Legionella pneumophila infection. PLoS ONE. 2009;4:e5706 pubmed publisher
    ..These findings suggest that L. pneumophila specifically disrupts mitochondrial protein synthesis in D. discoideum during the course of infection...
  55. Loens K, Beck T, Ursi D, Overdijk M, Sillekens P, Goossens H, et al. Evaluation of different nucleic acid amplification techniques for the detection of M. pneumoniae, C. pneumoniae and Legionella spp. in respiratory specimens from patients with community-acquired pneumonia. J Microbiol Methods. 2008;73:257-62 pubmed publisher
    ..It's practical attractiveness pleads for further optimalisation of the multiplex approach...
  56. De Gheldre Y, Maes N, Presti F, Etienne J, Struelens M. Rapid identification of clinically relevant Legionella spp. by analysis of transfer DNA intergenic spacer length polymorphism. J Clin Microbiol. 2001;39:162-9 pubmed
    ..tDNA-ILP analysis is proposed as a routinely applicable method which allows rapid identification of environmental and clinical isolates of Legionella spp. associated with legionellosis.