enterotoxemia

Summary

Summary: Disease caused by the liberation of exotoxins of CLOSTRIDIUM PERFRINGENS in the intestines of sheep, goats, cattle, foals, and piglets. Type B enterotoxemia in lambs is lamb dysentery; type C enterotoxemia in mature sheep produces "struck", and in calves, lambs and piglets it produces hemorrhagic enterotoxemia; type D enterotoxemia in sheep and goats is pulpy-kidney disease or overeating disease.

Webpages

  1. novartis animal health us, inc
    www.livestock.novartis.com/swine.html
  2. gas gangrene clinical resources
    guam-dl.slis.ua.edu/clinical/infectious/byorganism/bacterial ...
  3. gas gangrene clinical resources
    fsumed-dl.slis.ua.edu/clinical/infectious/byorganism/bacteri ...
  4. cornell science news: enterotoxemia vaccinations
    www.news.cornell.edu/releases/Dec97/lambshots.bpf.html
  5. ncr379 sheep diseases | university of missouri extension
    www.extension.missouri.edu/explore/regpubs/ncr379.htm
  6. microbiology
    addl.purdue.edu/userguide/Bacteriology/bact_result.asp?disea ...
  7. microbiology
    www.addl.purdue.edu/userguide/Bacteriology/bact_result.asp?d ...
  8. pigs - vaccines
    www.intervet.com/species/pigs/vaccines.aspx
  9. novartis animal health us, inc. - cattle diseases dairy cattle diseases beef cattle diseases
    www.livestock.novartis.com/cattle_diseases.html
  10. sheep 201: flock vaccinations
    www.sheep101.info/201/vaccinations.html

Research Grants

  1. Functional analysis of C. perfringens epsilon toxin
    J Glenn Songer; Fiscal Year: 2006
  2. Inhibition of Clostridium perfringens epsilon toxin
    Mark S McClain; Fiscal Year: 2008
  3. Inhibitors to Clostridium perfrigens epsilon toxin
    Mark S McClain; Fiscal Year: 2007

Publications

  1. Comparison of four techniques for the detection of Clostridium perfringens type D epsilon toxin in intestinal contents and other body fluids of sheep and goats
    F A Uzal
    School of Veterinary Sciences and Animal Production, The University of Queensland, Brisbane, Queensland, Australia
    J Vet Diagn Invest 15:94-9
  2. The pathology of peracute experimental Clostridium perfringens type D enterotoxemia in sheep
    F A Uzal
    The National Institute of Agricultural Technology, 8400 Bariloche, Argentina
    J Vet Diagn Invest 16:403-11
  3. The early effects of Clostridium perfringens type D epsilon toxin in ligated intestinal loops of goats and sheep
    M E Fernandez Miyakawa
    Animal Health Unit, The National Institute of Agricultural Technology, Bariloche, Argentina
    Vet Res Commun 27:231-41
  4. Evaluation of different fluids for detection of Clostridium perfringens type D epsilon toxin in sheep with experimental enterotoxemia
    Jorge E Layana
    The National Institute of Agricultural Technology CC 277, 8400 Bariloche, Argentina
    Anaerobe 12:204-6
  5. Pathogenesis of brain damage produced in sheep by Clostridium perfringens type D epsilon toxin: a review
    J W Finnie
    Veterinary Services Division, Institute of Medical and Veterinary Science, 101 Blacks Road, Gilles Plains 5086, South Australia
    Aust Vet J 81:219-21
  6. The distribution and frequency of Clostridium perfringens toxinotypes in healthy sheep in Benin, West Africa
    A Aschfalk
    Institute of Animal Hygiene and Environmental Protection, Free University of Berlin, Germany
    Trop Anim Health Prod 34:289-93
  7. Clostridium perfringens toxin types from wild-caught Atlantic cod (Gadus morhua L.), determined by PCR and ELISA
    A Aschfalk
    The Norwegian School of Veterinary Science, Department of Arctic Veterinary Medicine, Tromsø
    Can J Microbiol 48:365-8
  8. Clostridium perfringens type A and beta2 toxin associated with enterotoxemia in a 5-week-old goat
    Tammy Dray
    Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1
    Can Vet J 45:251-3
  9. Quality assurance of C. perfringens epsilon toxoid vaccines--ELISA versus mouse neutralisation test
    Ute Rosskopf Streicher
    Paul Ehrlich Institut, D Langen, Germany
    ALTEX 21:65-9
  10. Antibody responses of mares to prepartum vaccination with Clostridium perfringens bacterin and beta2 toxin
    J F Timoney
    Gluck Equine Research Center, University of Kentucky, Lexington, KY 40546, USA
    Vet Rec 157:810-2

Scientific Experts

  • A Aschfalk
  • D Michael Rings
  • R A Fairley
  • M Lebrun
  • Mark S McClain
  • J Glenn Songer
  • F A Uzal
  • Mariano E Fernandez Miyakawa
  • Benjamin H Cassutto
  • S Albini
  • S F E Scholes
  • Francisco A Uzal
  • Jorge E Layana
  • Mads F Bertelsen
  • Grazia Greco
  • J F Timoney
  • P Boujon
  • Ute Rosskopf Streicher
  • Tammy Dray
  • W R Kelly
  • J W Finnie
  • M E Fernandez Miyakawa
  • C Manteca
  • I Brodard
  • A Jaussi
  • J Frey
  • R Miserez
  • N Wollschlaeger
  • C Abril
  • D de B Welchman
  • Mariano E Fernandez-Miyakawa
  • Bruce A McClane
  • Vicki Adams
  • Derek J Fisher
  • Julian Saputo
  • E S Mitchell
  • Sameera Sayeed
  • J P Hutchinson
  • G T Edwards
  • Julian I Rood
  • Rachael Poon
  • J Scott Weese
  • M Henzi
  • J Walker
  • Anna Madio
  • Marco Campolo
  • L Fallon
  • J-H Penseyres
  • Vito Martella
  • Marialaura Corrente
  • E Fallon
  • Domenico Buonavoglia
  • Canio Buonavoglia
  • L Belloy
  • M Hartmann
  • W E Morris
  • Esther Werner
  • Peter Volkers
  • Ute Rosskopf-Streicher
  • Kerstin Noeske
  • J Bermudez
  • R Thomas
  • F Galea
  • M Hornitzky
  • P Coppe
  • J G Mainil
  • A Linden
  • A Kaeckenbeeck
  • J Detilleux
  • A Ginter
  • Lydia Crystal Cook
  • V Pirson
  • T Jauniaux
  • G Daube

Detail Information

Webpages24

  1. novartis animal health us, inc
    www.livestock.novartis.com/swine.html
  2. gas gangrene clinical resources
    guam-dl.slis.ua.edu/clinical/infectious/byorganism/bacterial ...
  3. gas gangrene clinical resources
    fsumed-dl.slis.ua.edu/clinical/infectious/byorganism/bacteri ...
  4. cornell science news: enterotoxemia vaccinations
    www.news.cornell.edu/releases/Dec97/lambshots.bpf.html
  5. ncr379 sheep diseases | university of missouri extension
    www.extension.missouri.edu/explore/regpubs/ncr379.htm
  6. microbiology
    addl.purdue.edu/userguide/Bacteriology/bact_result.asp?disea ...
  7. microbiology
    www.addl.purdue.edu/userguide/Bacteriology/bact_result.asp?d ...
  8. pigs - vaccines
    www.intervet.com/species/pigs/vaccines.aspx
  9. novartis animal health us, inc. - cattle diseases dairy cattle diseases beef cattle diseases
    www.livestock.novartis.com/cattle_diseases.html
  10. sheep 201: flock vaccinations
    www.sheep101.info/201/vaccinations.html
  11. pigs - products
    www.intervet.com/species/pigs/products.aspx
  12. microbiology
    www.addl.purdue.edu/userguide/Bacteriology/bact_result.asp?d ...
  13. clostridium spp.梭狀桿菌整理 @ dorcas :: 痞客邦 pixnet
    blog.pixnet.net/DorcasChang/post/13398360
  14. university of nebraska–lincoln extension publications
    ianrpubs.unl.edu/animaldisease/g794.htm
  15. enterotoxemia
    www.cnpgc.embrapa.br/publicacoes/doc/doc65/enterotoxemia.htm ...

Research Grants3

  1. Functional analysis of C. perfringens epsilon toxin
    J Glenn Songer; Fiscal Year: 2006
    ..While best known for its role in pathogenesis of enteritis and enterotoxemia in domestic animals, its high toxicity, ease of production, even in developing nations, and ability to act ..
  2. Inhibition of Clostridium perfringens epsilon toxin
    Mark S McClain; Fiscal Year: 2008
    ..The Clostridium perfringens epsilon toxin, a Category B Select Agent, is responsible for a severe, often fatal enterotoxemia characterized by cardiac, pulmonary, kidney, and brain edema...
  3. Inhibitors to Clostridium perfrigens epsilon toxin
    Mark S McClain; Fiscal Year: 2007
    ..The Clostridium perfringens epsilon toxin, a Category B Select Agent, is responsible for a severe, often fatal enterotoxemia characterized by cardiac, pulmonary, kidney, and brain edema...

Publications22

  1. Comparison of four techniques for the detection of Clostridium perfringens type D epsilon toxin in intestinal contents and other body fluids of sheep and goats
    F A Uzal
    School of Veterinary Sciences and Animal Production, The University of Queensland, Brisbane, Queensland, Australia
    J Vet Diagn Invest 15:94-9
    ..Until more consistent results are achieved, the diagnosis of enterotoxemia should not only be based solely on epsilon toxin detection, but also on clinical and pathological data.
  2. The pathology of peracute experimental Clostridium perfringens type D enterotoxemia in sheep
    F A Uzal
    The National Institute of Agricultural Technology, 8400 Bariloche, Argentina
    J Vet Diagn Invest 16:403-11
    The pathological findings in sheep with peracute experimental Clostridium perfringens type D enterotoxemia are described...
  3. The early effects of Clostridium perfringens type D epsilon toxin in ligated intestinal loops of goats and sheep
    M E Fernandez Miyakawa
    Animal Health Unit, The National Institute of Agricultural Technology, Bariloche, Argentina
    Vet Res Commun 27:231-41
    ..These results suggest that epsilon toxin modifies ion and water transport in the small and the large intestine of goats and sheep through different mechanisms...
  4. Evaluation of different fluids for detection of Clostridium perfringens type D epsilon toxin in sheep with experimental enterotoxemia
    Jorge E Layana
    The National Institute of Agricultural Technology CC 277, 8400 Bariloche, Argentina
    Anaerobe 12:204-6
    b>Enterotoxemia caused by Clostridium perfringens type D is a highly lethal disease of sheep, goats and other ruminants. The diagnosis of this condition is usually confirmed by detection of epsilon toxin, a major exotoxin produced by C...
  5. Pathogenesis of brain damage produced in sheep by Clostridium perfringens type D epsilon toxin: a review
    J W Finnie
    Veterinary Services Division, Institute of Medical and Veterinary Science, 101 Blacks Road, Gilles Plains 5086, South Australia
    Aust Vet J 81:219-21
    ..These cases follow a more protracted clinical course, but death is the usual outcome. The precise pathogenesis of the focal brain damage found in subacutely intoxicated sheep is unresolved, but several possible mechanisms are discussed...
  6. The distribution and frequency of Clostridium perfringens toxinotypes in healthy sheep in Benin, West Africa
    A Aschfalk
    Institute of Animal Hygiene and Environmental Protection, Free University of Berlin, Germany
    Trop Anim Health Prod 34:289-93
  7. Clostridium perfringens toxin types from wild-caught Atlantic cod (Gadus morhua L.), determined by PCR and ELISA
    A Aschfalk
    The Norwegian School of Veterinary Science, Department of Arctic Veterinary Medicine, Tromsø
    Can J Microbiol 48:365-8
    ..This is the first detection of C. perfringens alpha and beta2 toxin in cod and of beta2 toxin in fish in general. The origin of this bacterium in cod is discussed...
  8. Clostridium perfringens type A and beta2 toxin associated with enterotoxemia in a 5-week-old goat
    Tammy Dray
    Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1
    Can Vet J 45:251-3
    ..Clostridium perfringens Type A was isolated. Some isolates carried the gene for beta2 toxin, suggesting a role for beta2 toxin in caprine enterotoxemia, a common cause of death in growing kids.
  9. Quality assurance of C. perfringens epsilon toxoid vaccines--ELISA versus mouse neutralisation test
    Ute Rosskopf Streicher
    Paul Ehrlich Institut, D Langen, Germany
    ALTEX 21:65-9
    ..This ELISA method was subjected to an international validation to verify whether the protocol and the precision can be transferred within and between the participating laboratories...
  10. Antibody responses of mares to prepartum vaccination with Clostridium perfringens bacterin and beta2 toxin
    J F Timoney
    Gluck Equine Research Center, University of Kentucky, Lexington, KY 40546, USA
    Vet Rec 157:810-2
  11. Development and application of an oral challenge mouse model for studying Clostridium perfringens type D infection
    Mariano E Fernandez Miyakawa
    California Animal Health and Food Safety Laboratory System, San Bernardino Branch, University of California Davis, 105 West Central Avenue, San Bernardino, CA 92408, USA
    Infect Immun 75:4282-8
    Clostridium perfringens type D isolates cause enterotoxemia in sheep, goats, and probably cattle...
  12. A role for the Clostridium perfringens beta2 toxin in bovine enterotoxaemia?
    C Manteca
    Department of Infectious and Parasitic Diseases Bacteriology, Veterinary Faculty, University of Liège, Belgium
    Vet Microbiol 86:191-202
    ..However, isolation of beta2-toxigenic C. perfringens does not confirm the clinical diagnosis of bovine enterotoxaemia and a clostridial cell counts must still be performed...
  13. Enterotoxemia associated with beta2 toxin-producing Clostridium perfringens type A in two Asiatic black bears (Selenarctos thibetanus)
    Grazia Greco
    Department of Animal Health and Wellbeing, Faculty of Veterinary Medicine, University of Bari, 70010 Valenzano, Italy
    J Vet Diagn Invest 17:186-9
    ..This finding suggests the existence of 2 cpb2 subtypes. This is the first report of enterotoxemia associated with the presence of C...
  14. Clostridium perfringens type D enterotoxaemia in neonatal lambs
    S F E Scholes
    Vet Rec 160:811-2
  15. Real-time multiplex PCR assays for reliable detection of Clostridium perfringens toxin genes in animal isolates
    S Albini
    Institute of Veterinary Bacteriology, Vetsuisse Faculty, University of Bern, Länggassstrasse 122, Bern, Switzerland
    Vet Microbiol 127:179-85
    ..Furthermore, the real-time PCR carried out as simplex allows to quantitate the copy numbers of plasmid-borne toxin genes in relation to the chromosomally located alpha-toxin gene...
  16. The expression of Clostridium perfringens consensus beta2 toxin is associated with bovine enterotoxaemia syndrome
    M Lebrun
    Department of Infectious and Parasitic Diseases Bacteriology, Faculty of Veterinary Medicine, University of Liège, Liège 4000, Belgium
    Vet Microbiol 120:151-7
    ..9%) and infrequently in isolates from healthy cattle (6.9%). These data suggest that the typical variant of the CPB2 toxin may play a role in the pathogenesis of cattle enterotoxaemia...
  17. Enterotoxaemia involving beta2-toxigenic Clostridium perfringens in a white stork (Ciconia ciconia)
    P Boujon
    Institut Galli-Valerio, Laboratory of the Veterinary Service, 1014 Lausanne, Switzerland
    Vet Rec 156:746-7
  18. Confused by results of study on use of fecal panel for dogs
    Benjamin H Cassutto
    J Am Vet Med Assoc 221:486; author reply 486-7
  19. An epidemiological survey of Clostridium perfringens-associated enterotoxemia at an army veterinary treatment facility
    Benjamin H Cassutto
    Okinawa Branch Veterinary Service, 18 MDG SCV Unit 5142, Kadena AB, Japan, APO AP 96368 5142
    Mil Med 167:219-22
    ..Service and to establish a relationship between dietary indiscretion and the presence of clostridial enterotoxemia. Stool samples were obtained from 38 control animals and 44 animals with vomiting and diarrhea during a 3-..
  20. Lesions in the brains of three cattle resembling the lesions of enterotoxaemia in lambs
    R A Fairley
    Gribbles Veterinary Diagnostic Laboratory, Lincoln University, Christchurch, New Zealand
    N Z Vet J 53:356-8
    ....
  21. Fatal clostridial enterotoxemia (Clostridium glycolicum) in an ornate Nile monitor (Varanus ornatus)
    Mads F Bertelsen
    Toronto Zoo, 361A Old Finch Avenue, Scarborough, Ontario M1B 5K7, Canada
    J Zoo Wildl Med 37:53-4
    b>Enterotoxemia caused by Clostridium glycolicum was identified as the cause of circulatory collapse and death in a female, 3-yr-old, captive-bred ornate Nile monitor (Varanus ornatus)...
  22. Clostridial disease associated with neurologic signs: tetanus, botulism, and enterotoxemia
    D Michael Rings
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, 601 Tharp Street, Columbus, OH 43210, USA
    Vet Clin North Am Food Anim Pract 20:379-91, vii-viii
    ..In addition, neurologic signs are described with C perfringens types C and D but are not the dominant feature of these diseases...