burkholderia infections

Summary

Summary: Infections with bacteria of the genus BURKHOLDERIA.

Top Publications

  1. Vergunst A, Meijer A, Renshaw S, O Callaghan D. Burkholderia cenocepacia creates an intramacrophage replication niche in zebrafish embryos, followed by bacterial dissemination and establishment of systemic infection. Infect Immun. 2010;78:1495-508 pubmed publisher
    ..Our data indicate that the zebrafish embryo is an excellent vertebrate model to dissect the molecular basis of intracellular replication and the early innate immune responses in this intricate host-pathogen interaction. ..
  2. Petrucca A, Cipriani P, Sessa R, Teggi A, Pustorino R, Santapaola D, et al. Burkholderia cenocepacia vaginal infection in patient with smoldering myeloma and chronic hepatitis C. Emerg Infect Dis. 2004;10:1957-9 pubmed
    ..Treatment with piperacillin/tazobactam eliminated B. cenocepacia infection and vaginal symptoms. ..
  3. Chandler J, Duerkop B, Hinz A, West T, Herman J, Churchill M, et al. Mutational analysis of Burkholderia thailandensis quorum sensing and self-aggregation. J Bacteriol. 2009;191:5901-9 pubmed publisher
    ..We propose that the key function of the BtaR1-BtaI1 quorum-sensing system is to cause cells to gather into aggregates once a sufficient population has been established. ..
  4. Caraher E, Duff C, Mullen T, Mc Keon S, Murphy P, Callaghan M, et al. Invasion and biofilm formation of Burkholderia dolosa is comparable with Burkholderia cenocepacia and Burkholderia multivorans. J Cyst Fibros. 2007;6:49-56 pubmed
    ..B. dolosa shows comparable virulence characteristics in vitro to the two most clinically relevant species indicating precautions should be taken when this species is identified in the CF population. ..
  5. Manno G, Dalmastri C, Tabacchioni S, Vandamme P, Lorini R, Minicucci L, et al. Epidemiology and clinical course of Burkholderia cepacia complex infections, particularly those caused by different Burkholderia cenocepacia strains, among patients attending an Italian Cystic Fibrosis Center. J Clin Microbiol. 2004;42:1491-7 pubmed
    ..No significant differences in lung function, body weight, and mortality rate were observed between patients infected with epidemic strains belonging to either B. cenocepacia IIIA or B. cenocepacia IIID. ..
  6. Campana S, Taccetti G, Ravenni N, Favari F, Cariani L, Sciacca A, et al. Transmission of Burkholderia cepacia complex: evidence for new epidemic clones infecting cystic fibrosis patients in Italy. J Clin Microbiol. 2005;43:5136-42 pubmed
    ..Finally, a third clone comprised nine B. pyrrocinia isolates belonging to recA RFLP type Se 13. They represented three PFGE clusters and were collected in three CF centers. ..
  7. Sousa S, Ramos C, Almeida F, Meirinhos Soares L, Wopperer J, Schwager S, et al. Burkholderia cenocepacia J2315 acyl carrier protein: a potential target for antimicrobials' development?. Microb Pathog. 2008;45:331-6 pubmed publisher
    ..pseudomallei and B. mallei. ..
  8. De Soyza A, Meachery G, Hester K, Nicholson A, Parry G, Tocewicz K, et al. Lung transplantation for patients with cystic fibrosis and Burkholderia cepacia complex infection: a single-center experience. J Heart Lung Transplant. 2010;29:1395-404 pubmed publisher
    ..Long-term survival in the non-B cenocepacia BCC group was excellent, without high rates of acute rejection or bronchiolitis obliterans syndrome (BOS) longer term, and these patients continue to be considered for lung transplantation. ..
  9. Waine D, Henry D, Baldwin A, Speert D, Honeybourne D, Mahenthiralingam E, et al. Reliability of multilocus sequence typing of the Burkholderia cepacia complex in cystic fibrosis. J Cyst Fibros. 2007;6:215-9 pubmed
    ..We investigated the molecular clock speed of the seven genes used in the multilocus sequence typing (MLST) scheme for these bacteria...

More Information

Publications92

  1. Leitão J, Sousa S, Ferreira A, Ramos C, Silva I, Moreira L. Pathogenicity, virulence factors, and strategies to fight against Burkholderia cepacia complex pathogens and related species. Appl Microbiol Biotechnol. 2010;87:31-40 pubmed publisher
    ..An overview of these aspects of Bcc pathogenesis and opportunities for the design of future therapies is presented and discussed in this work. ..
  2. West T, Hawn T, Skerrett S. Toll-like receptor signaling in airborne Burkholderia thailandensis infection. Infect Immun. 2009;77:5612-22 pubmed publisher
    ..TLR signaling in B. thailandensis infection is substantially comparable to signaling induced by virulent B. pseudomallei. These studies provide additional insights into the host-pathogen interaction in pneumonic Burkholderia infection...
  3. Chen Y, Hsiao Y, Lin H, Liu Y, Chen Y. CpG-modified plasmid DNA encoding flagellin improves immunogenicity and provides protection against Burkholderia pseudomallei infection in BALB/c mice. Infect Immun. 2006;74:1699-705 pubmed
    ..pseudomallei infection. This CpG-modified plasmid DNA vaccination is an important potential strategy that should be developed to protect against melioidosis. ..
  4. Zhou J, Chen Y, Tabibi S, Alba L, Garber E, Saiman L. Antimicrobial susceptibility and synergy studies of Burkholderia cepacia complex isolated from patients with cystic fibrosis. Antimicrob Agents Chemother. 2007;51:1085-8 pubmed
    ..Minocycline, meropenem, and ceftazidime were the most active, inhibiting 38%, 26%, and 23% of strains, respectively. Synergy was rarely noted (range, 1% to 15% of strains per antibiotic combination)...
  5. Lucero C, Cohen A, Trevino I, Rupp A, Harris M, Forkan Kelly S, et al. Outbreak of Burkholderia cepacia complex among ventilated pediatric patients linked to hospital sinks. Am J Infect Control. 2011;39:775-8 pubmed publisher
    ..Hospital tap water used during oral and tracheostomy care was identified as the most likely mechanism for transmission. ..
  6. Haraga A, West T, Brittnacher M, Skerrett S, Miller S. Burkholderia thailandensis as a model system for the study of the virulence-associated type III secretion system of Burkholderia pseudomallei. Infect Immun. 2008;76:5402-11 pubmed publisher
    ..Therefore, we propose B. thailandensis as a useful BSL-1 model system to study the role of the Bsa TTSS during Burkholderia infection of mammalian cells and animals. ..
  7. Vial L, Chapalain A, Groleau M, Déziel E. The various lifestyles of the Burkholderia cepacia complex species: a tribute to adaptation. Environ Microbiol. 2011;13:1-12 pubmed publisher
  8. Horsley A, Jones A. Antibiotic treatment for Burkholderia cepacia complex in people with cystic fibrosis experiencing a pulmonary exacerbation. Cochrane Database Syst Rev. 2012;10:CD009529 pubmed publisher
    ..There is a clear need for multi-centre randomised clinical trials to assess the effectiveness of different antibiotic regimens in cystic fibrosis patients infected with organisms of the Burkholderia cepacia complex. ..
  9. Reik R, Spilker T, LiPuma J. Distribution of Burkholderia cepacia complex species among isolates recovered from persons with or without cystic fibrosis. J Clin Microbiol. 2005;43:2926-8 pubmed
    ..Although all B. cepacia complex species were found, some were rarely identified. The distribution of species differed between the CF and non-CF populations and appears to be changing over time among CF patients. ..
  10. Coenye T, Spilker T, Van Schoor A, LiPuma J, Vandamme P. Recovery of Burkholderia cenocepacia strain PHDC from cystic fibrosis patients in Europe. Thorax. 2004;59:952-4 pubmed
    ..Subsequent analysis of these isolates using BOX-PCR confirmed that the European isolates and strain PHDC represent the same clone. Strain PHDC represents a second transatlantic B cenocepacia clone capable of colonising patients with CF. ..
  11. Thomson E, Dennis J. A Burkholderia cepacia complex non-ribosomal peptide-synthesized toxin is hemolytic and required for full virulence. Virulence. 2012;3:286-98 pubmed publisher
    ..Molecular screening identifies the Bcc species containing this gene cluster, of which several strains produce hemolytic activity...
  12. Courtney J, Dunbar K, McDowell A, Moore J, Warke T, Stevenson M, et al. Clinical outcome of Burkholderia cepacia complex infection in cystic fibrosis adults. J Cyst Fibros. 2004;3:93-8 pubmed
    ..The Burkholderia cepacia complex (BCC) is one of the most important groups of organisms infecting cystic fibrosis (CF) patients. The aim of the study was to examine how infection with BCC affects clinical outcome...
  13. Balkhy H, Cunningham G, Francis C, Almuneef M, Stevens G, Akkad N, et al. A National Guard outbreak of Burkholderia cepacia infection and colonization secondary to intrinsic contamination of albuterol nebulization solution. Am J Infect Control. 2005;33:182-8 pubmed
  14. Douce R, Zurita J, Sanchez O, Cardenas Aldaz P. Investigation of an outbreak of central venous catheter-associated bloodstream infection due to contaminated water. Infect Control Hosp Epidemiol. 2008;29:364-6 pubmed publisher
    ..Removal of these ampoules yielded a 10-fold reduction in the incidence of catheter-associated infection. ..
  15. Brisse S, Cordevant C, Vandamme P, Bidet P, Loukil C, Chabanon G, et al. Species distribution and ribotype diversity of Burkholderia cepacia complex isolates from French patients with cystic fibrosis. J Clin Microbiol. 2004;42:4824-7 pubmed
    ..B. multivorans genotype A (found in 32 French patients) and two other genotypes were also identified among isolates from Austrian, German, Italian, and Canadian patients. ..
  16. Zlosnik J, Hird T, Fraenkel M, Moreira L, Henry D, Speert D. Differential mucoid exopolysaccharide production by members of the Burkholderia cepacia complex. J Clin Microbiol. 2008;46:1470-3 pubmed publisher
    ..cenocepacia, the most virulent species of the complex, are most frequently nonmucoid. Additionally, isolates from patients with chronic infections can convert from mucoid to nonmucoid. ..
  17. Chu K, MacDonald K, Davidson D, Speert D. Persistence of Burkholderia multivorans within the pulmonary macrophage in the murine lung. Infect Immun. 2004;72:6142-7 pubmed
    ..multivorans-infected lungs localized bacteria to macrophages. Clearance of B. cenocepacia was associated with greater interleukin-1beta and neutrophil responses than the responses induced by B. multivorans. ..
  18. Baldwin A, Mahenthiralingam E, Drevinek P, Vandamme P, Govan J, Waine D, et al. Environmental Burkholderia cepacia complex isolates in human infections. Emerg Infect Dis. 2007;13:458-61 pubmed
    ..This finding links the natural environment with the emergence of many Bcc infections...
  19. Carmody L, Gill J, Summer E, Sajjan U, Gonzalez C, YOUNG R, et al. Efficacy of bacteriophage therapy in a model of Burkholderia cenocepacia pulmonary infection. J Infect Dis. 2010;201:264-71 pubmed publisher
    ..cenocepacia lung infection model. Systemic phage administration was more effective than inhalational administration, suggesting that circulating phages have better access to bacteria in lungs than do topical phages...
  20. Dizbay M, Tunccan O, Sezer B, Aktas F, Arman D. Nosocomial Burkholderia cepacia infections in a Turkish university hospital: a five-year surveillance. J Infect Dev Ctries. 2009;3:273-7 pubmed
    ..However, infections caused by B. cepacia should be taken into consideration because of their high mortality due to multidrug resistance in ICU settings. ..
  21. Yang C, Chen T, Liao L, Ma L, Wang C, Lu P, et al. Nosocomial outbreak of two strains of Burkholderia cepacia caused by contaminated heparin. J Hosp Infect. 2008;69:398-400 pubmed publisher
  22. Vanlaere E, Baldwin A, Gevers D, Henry D, De Brandt E, LiPuma J, et al. Taxon K, a complex within the Burkholderia cepacia complex, comprises at least two novel species, Burkholderia contaminans sp. nov. and Burkholderia lata sp. nov. Int J Syst Evol Microbiol. 2009;59:102-11 pubmed publisher
  23. LiPuma J. Update on the Burkholderia cepacia complex. Curr Opin Pulm Med. 2005;11:528-33 pubmed
  24. Pirone L, Bragonzi A, Farcomeni A, Paroni M, Auriche C, Conese M, et al. Burkholderia cenocepacia strains isolated from cystic fibrosis patients are apparently more invasive and more virulent than rhizosphere strains. Environ Microbiol. 2008;10:2773-84 pubmed publisher
    ..cenocepacia virulence, showed that they were present in B. cenocepacia strains irrespective of their origin. Overall, our results suggest that rhizosphere strains do not differ from clinical strains in some pathogenic traits...
  25. Seed K, Dennis J. Development of Galleria mellonella as an alternative infection model for the Burkholderia cepacia complex. Infect Immun. 2008;76:1267-75 pubmed publisher
    ..For experimentation examining the virulent properties of the BCC, the wax worm has proven to be a useful alternative infection model...
  26. Seed K, Dennis J. Experimental bacteriophage therapy increases survival of Galleria mellonella larvae infected with clinically relevant strains of the Burkholderia cepacia complex. Antimicrob Agents Chemother. 2009;53:2205-8 pubmed publisher
    ..In a caterpillar infection model, we show that BCC phage therapy is an alternative treatment possibility and is highly effective under specific conditions...
  27. Charoensap J, Utaisincharoen P, Engering A, Sirisinha S. Differential intracellular fate of Burkholderia pseudomallei 844 and Burkholderia thailandensis UE5 in human monocyte-derived dendritic cells and macrophages. BMC Immunol. 2009;10:20 pubmed publisher
    ..pseudomallei strain 844 (Bp-844) in human monocyte-derived dendritic cells (MoDCs) and macrophages (Mphis), as well as its ability to stimulate host cell responses with those of B. thailandensis strain UE5 (Bt-UE5)...
  28. Chattoraj S, Murthy R, Ganesan S, Goldberg J, Zhao Y, Hershenson M, et al. Pseudomonas aeruginosa alginate promotes Burkholderia cenocepacia persistence in cystic fibrosis transmembrane conductance regulator knockout mice. Infect Immun. 2010;78:984-93 pubmed publisher
    ..These observations suggest that P. aeruginosa alginate may facilitate B. cenocepacia infection by interfering with host innate defense mechanisms...
  29. Govan J, Brown A, Jones A. Evolving epidemiology of Pseudomonas aeruginosa and the Burkholderia cepacia complex in cystic fibrosis lung infection. Future Microbiol. 2007;2:153-64 pubmed
    ..Strict cross-infection control was prompted by early epidemiological experience of the B. cepacia complex and is essential in the management of all CF pathogens...
  30. Jacobson M, Wray R, Kovach D, Henry D, Speert D, Matlow A. Sustained endemicity of Burkholderia cepacia complex in a pediatric institution, associated with contaminated ultrasound gel. Infect Control Hosp Epidemiol. 2006;27:362-6 pubmed
    ..To determine whether contaminated ultrasound gel is the source of intermittent outbreaks of nosocomial infection due to Burkholderia cepacia complex in patients without cystic fibrosis since 1992...
  31. Abe K, D Angelo M, Sunenshine R, Noble Wang J, Cope J, Jensen B, et al. Outbreak of Burkholderia cepacia bloodstream infection at an outpatient hematology and oncology practice. Infect Control Hosp Epidemiol. 2007;28:1311-3 pubmed
    ..Though we did not identify the source of the organism, our findings support the hypothesis that cross-contamination of multidose medications through the use of the same needle and syringe was a contributing factor...
  32. Morici L, Heang J, Tate T, Didier P, Roy C. Differential susceptibility of inbred mouse strains to Burkholderia thailandensis aerosol infection. Microb Pathog. 2010;48:9-17 pubmed publisher
    ..These results demonstrate that B. thailandensis can be used as a surrogate for experimental laboratory investigation of melioidosis in small animal models and that TLR4 may not play a prominent role during acute pneumonic melioidosis...
  33. McClean S, Callaghan M. Burkholderia cepacia complex: epithelial cell-pathogen confrontations and potential for therapeutic intervention. J Med Microbiol. 2009;58:1-12 pubmed publisher
    ..This review outlines these interactions and examines the therapeutic implications of understanding the mechanisms of pathogenesis of this difficult, antibiotic-resistant, opportunistic pathogen...
  34. Vandamme P, Dawyndt P. Classification and identification of the Burkholderia cepacia complex: Past, present and future. Syst Appl Microbiol. 2011;34:87-95 pubmed publisher
  35. Mariappan V, Vellasamy K, Thimma J, Hashim O, Vadivelu J. Identification of immunogenic proteins from Burkholderia cepacia secretome using proteomic analysis. Vaccine. 2010;28:1318-24 pubmed publisher
    ..Eighteen of these immunogenic proteins which reacted with all three antibodies were identified and might be potential molecules as a diagnostic marker or a putative candidate vaccine against B. cepacia infections...
  36. Kooi C, Sokol P. Burkholderia cenocepacia zinc metalloproteases influence resistance to antimicrobial peptides. Microbiology. 2009;155:2818-25 pubmed publisher
    ..These studies suggest that ZmpA and ZmpB may influence the resistance of B. cenocepacia to host antimicrobial peptides as well as alter the host protease/anti-protease balance in chronic respiratory infections...
  37. Kidd T, Douglas J, Bergh H, Coulter C, Bell S. Burkholderia cepacia complex epidemiology in persons with cystic fibrosis from Australia and New Zealand. Res Microbiol. 2008;159:194-9 pubmed publisher
    ..Although person-to-person transmission of B. cenocepacia strains has occurred in Australia, the majority of CF-related Bcc infections in Australia and New Zealand are most likely acquired from the environment...
  38. Cesarini S, Bevivino A, Tabacchioni S, Chiarini L, Dalmastri C. RecA gene sequence and Multilocus Sequence Typing for species-level resolution of Burkholderia cepacia complex isolates. Lett Appl Microbiol. 2009;49:580-8 pubmed publisher
    ..To identify, by means of recA sequencing and multilocus sequence typing (MLST), Burkholderia cepacia complex (BCC) isolates of environmental and clinical origin, which failed to be identified by recA RFLP and species-specific PCR...
  39. Carvalho A, Ventura G, Pereira C, Leão R, Folescu T, Higa L, et al. Burkholderia cenocepacia, B. multivorans, B. ambifaria and B. vietnamiensis isolates from cystic fibrosis patients have different profiles of exoenzyme production. APMIS. 2007;115:311-8 pubmed
    ..multivorans was higher than in the other species. We speculate that the differential characteristics of exoenzyme production may account for the differences in the pathogenic potentials of each BCC species...
  40. De Smet B, Veng C, Kruy L, Kham C, van Griensven J, Peeters C, et al. Outbreak of Burkholderia cepacia bloodstream infections traced to the use of Ringer lactate solution as multiple-dose vial for catheter flushing, Phnom Penh, Cambodia. Clin Microbiol Infect. 2013;19:832-7 pubmed publisher
    ..The use of multiple-dose vials should be avoided and newly introduced procedures should be assessed for infection control risks...
  41. Loutet S, Valvano M. A decade of Burkholderia cenocepacia virulence determinant research. Infect Immun. 2010;78:4088-100 pubmed publisher
    ..cenocepacia establishes chronic infections in immunocompromised patients, which depend more on determinants mediating host niche adaptation than those involved directly in host cells and tissue damage...
  42. Boon C, Deng Y, Wang L, He Y, Xu J, Fan Y, et al. A novel DSF-like signal from Burkholderia cenocepacia interferes with Candida albicans morphological transition. ISME J. 2008;2:27-36 pubmed
  43. Huynh K, Plumb J, Downey G, Valvano M, Grinstein S. Inactivation of macrophage Rab7 by Burkholderia cenocepacia. J Innate Immun. 2010;2:522-33 pubmed publisher
    ..Jointly, these experiments indicate that B. cenocepacia express virulence factors capable of interfering with Rab7 function and thereby with membrane traffic...
  44. Yoder Himes D, Konstantinidis K, Tiedje J. Identification of potential therapeutic targets for Burkholderia cenocepacia by comparative transcriptomics. PLoS ONE. 2010;5:e8724 pubmed publisher
    ..The identification of virulence factors and potential therapeutic targets has been hampered by the genomic diversity within the species as many factors are not shared among the pathogenic members of the species...
  45. Martin M, Christiansen B, Caspari G, Hogardt M, von Thomsen A, Ott E, et al. Hospital-wide outbreak of Burkholderia contaminans caused by prefabricated moist washcloths. J Hosp Infect. 2011;77:267-70 pubmed publisher
    ..In case of infections due to contaminated products, immediate communication to healthcare authorities is required, including RAPEX warning if products are sold across Europe...
  46. Mahenthiralingam E, Urban T, Goldberg J. The multifarious, multireplicon Burkholderia cepacia complex. Nat Rev Microbiol. 2005;3:144-56 pubmed
    ..Here we highlight the unique characteristics of the Bcc, focusing on the factors that determine virulence...
  47. Moura J, Cristina de Assis M, Ventura G, Saliba A, Gonzaga L, Si Tahar M, et al. Differential interaction of bacterial species from the Burkholderia cepacia complex with human airway epithelial cells. Microbes Infect. 2008;10:52-9 pubmed
    ..Hence, our data demonstrate, for the first time, that all BCC species exhibit a similar ability to induce the expression of host immune mediators whereas they differ on their ability to adhere to, invade and kill airway epithelial cells...
  48. Ryan R, McCarthy Y, Watt S, Niehaus K, Dow J. Intraspecies signaling involving the diffusible signal factor BDSF (cis-2-dodecenoic acid) influences virulence in Burkholderia cenocepacia. J Bacteriol. 2009;191:5013-9 pubmed publisher
    ..Here, we show that BDSF also acts as an intraspecies signal in B. cenocepacia to control factors contributing to virulence of this major opportunistic pathogen...
  49. Sim B, Chantratita N, Ooi W, Nandi T, Tewhey R, Wuthiekanun V, et al. Genomic acquisition of a capsular polysaccharide virulence cluster by non-pathogenic Burkholderia isolates. Genome Biol. 2010;11:R89 pubmed publisher
    ..To study B. thailandensis genomic variation, we profiled 50 isolates using a pan-genome microarray comprising genomic elements from 28 Burkholderia strains and species...
  50. Peacock S, Schweizer H, Dance D, Smith T, Gee J, Wuthiekanun V, et al. Management of accidental laboratory exposure to Burkholderia pseudomallei and B. mallei. Emerg Infect Dis. 2008;14:e2 pubmed publisher
    ..pseudomallei. The overall mortality rate of infected persons is 50% in northeast Thailand (35% in children) and 19% in Australia...
  51. Engledow A, Medrano E, Mahenthiralingam E, LiPuma J, Gonzalez C. Involvement of a plasmid-encoded type IV secretion system in the plant tissue watersoaking phenotype of Burkholderia cenocepacia. J Bacteriol. 2004;186:6015-24 pubmed
    ..Our findings indicate that in strain K56-2, the plasmid-encoded Ptw type IV secretion system is responsible for the secretion of a plant cytotoxic protein(s)...
  52. Lieberman T, Michel J, Aingaran M, Potter Bynoe G, Roux D, Davis M, et al. Parallel bacterial evolution within multiple patients identifies candidate pathogenicity genes. Nat Genet. 2011;43:1275-80 pubmed publisher
    ..The identification of parallel molecular evolution as a pathogen spreads among multiple individuals points to the key selection forces it experiences within human hosts...
  53. Ortega X, Hunt T, Loutet S, Vinion Dubiel A, Datta A, Choudhury B, et al. Reconstitution of O-specific lipopolysaccharide expression in Burkholderia cenocepacia strain J2315, which is associated with transmissible infections in patients with cystic fibrosis. J Bacteriol. 2005;187:1324-33 pubmed
  54. Bakkal S, Robinson S, Ordonez C, Waltz D, Riley M. Role of bacteriocins in mediating interactions of bacterial isolates taken from cystic fibrosis patients. Microbiology. 2010;156:2058-67 pubmed publisher
    ..These data suggest that bacteriocin-based inhibition may play a role in governing Pa and Bcc interactions in the CF lung and may, therefore, offer a novel approach to mediating these often fatal infections...
  55. Loutet S, Flannagan R, Kooi C, Sokol P, Valvano M. A complete lipopolysaccharide inner core oligosaccharide is required for resistance of Burkholderia cenocepacia to antimicrobial peptides and bacterial survival in vivo. J Bacteriol. 2006;188:2073-80 pubmed
    ..Together, these data show that the B. cenocepacia LPS inner core oligosaccharide is needed for in vitro resistance to three structurally unrelated antimicrobial peptides and for in vivo survival in a rat model of chronic lung infection...
  56. Mahenthiralingam E, Baldwin A, Drevinek P, Vanlaere E, Vandamme P, LiPuma J, et al. Multilocus sequence typing breathes life into a microbial metagenome. PLoS ONE. 2006;1:e17 pubmed
  57. Mann T, Ben David D, Zlotkin A, Shachar D, Keller N, Toren A, et al. An outbreak of Burkholderia cenocepacia bacteremia in immunocompromised oncology patients. Infection. 2010;38:187-94 pubmed publisher
    ..We describe an outbreak of B. cenocepacia bacteremia among hospitalized oncology patients...
  58. Visser M, Majumdar S, Hani E, Sokol P. Importance of the ornibactin and pyochelin siderophore transport systems in Burkholderia cenocepacia lung infections. Infect Immun. 2004;72:2850-7 pubmed
    ..These studies suggest that the ornibactin uptake system is the most important siderophore-mediated iron transport system in B. cenocepacia lung infections...
  59. Viktorov D, Zakharova I, Podshivalova M, Kalinkina E, Merinova O, Ageeva N, et al. High-level resistance to fluoroquinolones and cephalosporins in Burkholderia pseudomallei and closely related species. Trans R Soc Trop Med Hyg. 2008;102 Suppl 1:S103-10 pubmed publisher
  60. Jones A, Dodd M, Govan J, Barcus V, Doherty C, Morris J, et al. Burkholderia cenocepacia and Burkholderia multivorans: influence on survival in cystic fibrosis. Thorax. 2004;59:948-51 pubmed
    ..The clinical outcome of infection with the two most commonly isolated genomovars (B cenocepacia and B multivorans) was studied at a specialist CF centre between 1982 and 2003...
  61. Lynch K, Dennis J. Development of a species-specific fur gene-based method for identification of the Burkholderia cepacia complex. J Clin Microbiol. 2008;46:447-55 pubmed
    ..This assay is useful for the rapid, definitive identification of all nine current BCC species and potentially novel species groups...
  62. Mahenthiralingam E, Baldwin A, Dowson C. Burkholderia cepacia complex bacteria: opportunistic pathogens with important natural biology. J Appl Microbiol. 2008;104:1539-51 pubmed publisher
    ..In the last 10 years considerable progress has been made in understanding the natural biology and clinical infections caused by this fascinating group of bacteria...
  63. Drevinek P, Vosahlikova S, Cinek O, Vavrova V, Bartosova J, Pohunek P, et al. Widespread clone of Burkholderia cenocepacia in cystic fibrosis patients in the Czech Republic. J Med Microbiol. 2005;54:655-9 pubmed
    ..cepacia epidemic strain marker, PCR negativity for the cable pilin subunit gene and close genetic relatedness to the epidemic strain of RAPD 01 type previously identified in Canada...
  64. Kim H, Schell M, Yu Y, Ulrich R, Sarria S, Nierman W, et al. Bacterial genome adaptation to niches: divergence of the potential virulence genes in three Burkholderia species of different survival strategies. BMC Genomics. 2005;6:174 pubmed
    ..To investigate the genomic factors resulting in such a dramatic difference, we first identified the Bm genes responsive to the mouse environment, and then examined the divergence of these genes in Bp and Bt...
  65. Zlosnik J, Costa P, Brant R, Mori P, Hird T, Fraenkel M, et al. Mucoid and nonmucoid Burkholderia cepacia complex bacteria in cystic fibrosis infections. Am J Respir Crit Care Med. 2011;183:67-72 pubmed publisher
    ..Some BCC, but not others, elaborate copious mucoid exopolysaccharide, endowing them with a gross mucoid phenotype, the clinical significance of which has not been described...
  66. Martins I, Pellegrino F, Freitas A, Santos M, Ferraiuoli G, Vasques M, et al. Case-crossover study of Burkholderia cepacia complex bloodstream infection associated with contaminated intravenous bromopride. Infect Control Hosp Epidemiol. 2010;31:516-21 pubmed publisher
    ..To investigate an outbreak of healthcare-associated Burkholderia cepacia complex (BCC) primary bloodstream infections (BCC-BSI)...
  67. Pope C, Gillespie S, Moore J, McHugh T. Approaches to measure the fitness of Burkholderia cepacia complex isolates. J Med Microbiol. 2010;59:679-86 pubmed publisher
    ..Unlike in Pseudomonas aeruginosa where hypermutability has been detected in strains isolated from CF patients, we were unable to demonstrate hypermutability in this panel of Burkholderia cenocepacia and Burkholderia multivorans isolates...
  68. Saldías M, Valvano M. Interactions of Burkholderia cenocepacia and other Burkholderia cepacia complex bacteria with epithelial and phagocytic cells. Microbiology. 2009;155:2809-17 pubmed publisher
    ..This review summarizes recent findings concerning the interaction between Bcc bacteria and epithelial and phagocytic cells...
  69. Romero Gómez M, Quiles Melero M, Peña García P, Gutiérrez Altés A, García de Miguel M, Jimenez C, et al. Outbreak of Burkholderia cepacia bacteremia caused by contaminated chlorhexidine in a hemodialysis unit. Infect Control Hosp Epidemiol. 2008;29:377-8 pubmed publisher
  70. Alexander B, Petzold E, Reller L, Palmer S, Davis R, Woods C, et al. Survival after lung transplantation of cystic fibrosis patients infected with Burkholderia cepacia complex. Am J Transplant. 2008;8:1025-30 pubmed publisher
    ..00005). Following LT, infection with Bcc species other than B. cenocepacia does not significantly impact 5-year survival whereas infection with B. cenocepacia pretransplant is associated with decreased survival...
  71. De Boeck K, Malfroot A, Van Schil L, Lebecque P, Knoop C, Govan J, et al. Epidemiology of Burkholderia cepacia complex colonisation in cystic fibrosis patients. Eur Respir J. 2004;23:851-6 pubmed
    ..The cross-infection rate is low. Three patients had transient colonisation. The impact of Burkholderia cepacia complex on morbidity in the Belgian cystic fibrosis population is high and not limited to Burkholderia cenocepacia...
  72. Conway B, Chu K, Bylund J, Altman E, Speert D. Production of exopolysaccharide by Burkholderia cenocepacia results in altered cell-surface interactions and altered bacterial clearance in mice. J Infect Dis. 2004;190:957-66 pubmed
    ..This mucoid colonial appearance could enhance the persistence and virulence of this important CF-related pathogen...
  73. Baldwin A, Mahenthiralingam E, Drevinek P, Pope C, Waine D, Henry D, et al. Elucidating global epidemiology of Burkholderia multivorans in cases of cystic fibrosis by multilocus sequence typing. J Clin Microbiol. 2008;46:290-5 pubmed
    ..multivorans...
  74. Cheung K, Li G, Urban T, Goldberg J, Griffith A, Lu F, et al. Pilus-mediated epithelial cell death in response to infection with Burkholderia cenocepacia. Microbes Infect. 2007;9:829-37 pubmed
    ..Understanding the role of cbl pili in the pathogenesis of B. cenocepacia infections offers the potential for decreasing the virulence of these potentially life-threatening organisms in CF patients...
  75. Godshall M. Mounting a defense against Burkholderia cepacia. Nursing. 2005;35:18-9 pubmed
  76. Subramoni S, Nguyen D, Sokol P. Burkholderia cenocepacia ShvR-regulated genes that influence colony morphology, biofilm formation, and virulence. Infect Immun. 2011;79:2984-97 pubmed publisher
    ..Together, our data show that the ShvR-regulated genes BCAS0208 to BCAS0201 are required for the rough colony morphotype, biofilm and pellicle formation, and virulence in B. cenocepacia...
  77. McDowell A, Mahenthiralingam E, Dunbar K, Moore J, Crowe M, Elborn J. Epidemiology of Burkholderia cepacia complex species recovered from cystic fibrosis patients: issues related to patient segregation. J Med Microbiol. 2004;53:663-8 pubmed
    ..It is therefore suggested that CF centres cohort patients based on the presence or absence of B. cepacia complex infection and not on the basis of transmissibility marker-positive B. cenocepacia as previously suggested...
  78. Ghazal S, Al Mudaimeegh K, Al Fakihi E, Asery A. Outbreak of Burkholderia cepacia bacteremia in immunocompetent children caused by contaminated nebulized sulbutamol in Saudi Arabia. Am J Infect Control. 2006;34:394-8 pubmed
    ..The Infection Control Department (ICD) in the King Fahad Medical City (KFMC) detected and investigated the outbreak to identify the source of the organism and mode of transmission...
  79. DeShazer D. Virulence of clinical and environmental isolates of Burkholderia oklahomensis and Burkholderia thailandensis in hamsters and mice. FEMS Microbiol Lett. 2007;277:64-9 pubmed
    ..The virulence of B. thailandensis CDC3015869, on the other hand, was more similar to the virulence of isolates of B. thailandensis from Southeast Asia...
  80. Aubert D, MacDonald D, Valvano M. BcsKC is an essential protein for the type VI secretion system activity in Burkholderia cenocepacia that forms an outer membrane complex with BcsLB. J Biol Chem. 2010;285:35988-98 pubmed publisher
    ..Together, our data show that BcsK(C)/BcsL(B) interaction is essential for the T6SS activity in B. cenocepacia...
  81. Savoia D, Deplano C, Zucca M. Pseudomonas aeruginosa and Burkholderia cenocepacia infections in patients affected by cystic fibrosis: serum resistance and antibody response. Immunol Invest. 2008;37:19-27 pubmed publisher
    ..aeruginosa was higher than that against B. cenocepacia. The contribution of these data to the assessment of the importance of the humoral immune response in CF pulmonary infections by Pseudomonas and Burkholderia is briefly discussed...
  82. Drevinek P, Vosahlikova S, Dedeckova K, Cinek O, Mahenthiralingam E. Direct culture-independent Strain typing of Burkholderia cepacia complex in sputum samples from patients with cystic fibrosis. J Clin Microbiol. 2010;48:1888-91 pubmed publisher
    ..The redesigned nested-PCR MLST format was successfully used to accurately identify strains in 23 sputum samples, of which 8 were culture negative...
  83. McCarthy Y, Yang L, Twomey K, Sass A, Tolker Nielsen T, Mahenthiralingam E, et al. A sensor kinase recognizing the cell-cell signal BDSF (cis-2-dodecenoic acid) regulates virulence in Burkholderia cenocepacia. Mol Microbiol. 2010;77:1220-36 pubmed publisher
    ..The findings identify BCAM0227 as a novel BDSF sensor and a potential target for interference in virulence-related signalling in B. cenocepacia...