nocardia infections

Summary

Summary: Infections with bacteria of the genus NOCARDIA.

Top Publications

  1. Minero M, Marin M, Cercenado E, Rabadán P, Bouza E, Munoz P. Nocardiosis at the turn of the century. Medicine (Baltimore). 2009;88:250-61 pubmed publisher
    ..The incidence of Nocardia infections did not increase significantly during the study period (0.39/100,000 inhabitants in 1995-1998 and 0...
  2. Tan C, Lai C, Lin S, Liao C, Chou C, Hsu H, et al. Clinical and microbiological characteristics of Nocardiosis including those caused by emerging Nocardia species in Taiwan, 1998-2008. Clin Microbiol Infect. 2010;16:966-72 pubmed publisher
    ..In conclusion, the clinical and microbiological manifestations of Nocardiosis vary with the different Nocardia species. Accurate identification of the species is crucial to make the diagnosis...
  3. Jodlowski T, Melnychuk I, Conry J. Linezolid for the treatment of Nocardia spp. infections. Ann Pharmacother. 2007;41:1694-9 pubmed
    ..To review the available evidence regarding the use of linezolid for the treatment of Nocardia spp. infections...
  4. Chedid M, Chedid M, Porto N, Severo C, Severo L. Nocardial infections: report of 22 cases. Rev Inst Med Trop Sao Paulo. 2007;49:239-46 pubmed
    ..We propose that the delay in diagnosis should be examined in larger series to document its influence in the prognosis of the disease...
  5. Espinoza González N, Welsh O, de Torres N, Cavazos Rocha N, Ocampo Candiani J, Said Fernandez S, et al. Efficacy of DA-7218, a new oxazolidinone prodrug, in the treatment of experimental actinomycetoma produced by Nocardia brasiliensis. Molecules. 2008;13:31-40 pubmed
    ..001), proving that DA-7218 is effective for the treatment of experimental murine actinomycetoma. This compound could be a potential option for patients affected with mycetoma by Nocardia brasiliensis...
  6. Ghalib M, Hassan I. Prolonged unconsciousness in a patient with End-stage Renal Disease. Saudi J Kidney Dis Transpl. 2006;17:273-7 pubmed
    ..However, the patient was treated successfully, surgically and chemotherapeutically. He was discharged home in a good condition...
  7. Maraki S, Scoulica E, Nioti E, Tselentis Y. Nocardial infection in Crete, Greece: review of fifteen cases from 2003 to 2007. Scand J Infect Dis. 2009;41:122-7 pubmed publisher
    ..Nocardiosis is a rare but sometimes life-threatening infection, complicating immunosuppression. Early diagnosis and timely administration of appropriate treatment result in a favourable outcome...
  8. Peleg A, Husain S, Qureshi Z, Silveira F, Sarumi M, Shutt K, et al. Risk factors, clinical characteristics, and outcome of Nocardia infection in organ transplant recipients: a matched case-control study. Clin Infect Dis. 2007;44:1307-14 pubmed
    ..Risk factors for Nocardia infection in organ transplant recipients have not been formally assessed in the current era of transplantation...
  9. Bonnet F, Donay J, Fieux F, Marie O, De Kerviler E, Jacob L. [Postoperative nocardiosis caused by Nocardia otitidiscaviarum: pitfalls and delayed diagnosis]. Ann Fr Anesth Reanim. 2007;26:680-4 pubmed
    ..Recommendations are proposed regarding physicians' role and optimized microbiological procedures for recognition of slowly growing nocardial strains...

More Information

Publications66

  1. Brasileiro R, Pinho A, Medeiros C, Ferri F, Schiavon L, Narciso Schiavon J, et al. [Pulmonary nocardiosis in a patient who was a chronic corticosteroid user]. Rev Soc Bras Med Trop. 2007;40:585-7 pubmed
    ..He developed pulmonary infection due to Nocardia farcinica, which was isolated from blood cultures. Despite correct treatment with trimethoprim-sulfamethoxazole, the patient died three months after this therapy was instituted...
  2. Alnaum H, Elhassan M, Mustafa F, Hamid M. Prevalence of Nocardia species among HIV-positive patients with suspected tuberculosis. Trop Doct. 2011;41:224-6 pubmed publisher
    ..Nocardia spp. cause pulmonary infections (4.09%) in both immunocompetent (2.92%) as well as immunocompromised (1.17%) patients who attend chest clinics in Sudan...
  3. Rivero A, Garcia Lazaro M, Perez Camacho I, Natera C, del Carmen Almodovar M, Camacho A, et al. Successful long-term treatment with linezolid for disseminated infection with multiresistant Nocardia farcinica. Infection. 2008;36:389-91 pubmed publisher
  4. Rasheed M, Belay G. Nocardiosis in HIV seropositive clinically suspected pulmonary tuberculosis patients. Trop Doct. 2008;38:34-5 pubmed publisher
    ..Clinicians should be aware of this entity in HIV/immunocompromised patients with respiratory infections who fail to respond to antituberculous treatment...
  5. Martinez R, Reyes S, Menendez R. Pulmonary nocardiosis: risk factors, clinical features, diagnosis and prognosis. Curr Opin Pulm Med. 2008;14:219-27 pubmed publisher
    ..This review analyzes the current situation, in order to better understand this infection and enhance awareness and clinical suspicion that would lead to further specific microbiological studies and treatment...
  6. Martínez Tomás R, Menéndez Villanueva R, Reyes Calzada S, Santos Durantez M, Vallés Tarazona J, Modesto Alapont M, et al. Pulmonary nocardiosis: risk factors and outcomes. Respirology. 2007;12:394-400 pubmed
    ..which can behave either as opportunistic or primary pathogens. The present study identifies the risk factors for PN, clinical symptoms and radiographic features and the factors that affect its prognosis...
  7. Mizota A, Haki K, Shiina C, Tanaka M, Nakazawa T, Yazawa K, et al. The first case of keratitis caused by Nocardia exalbida. Int Ophthalmol. 2007;27:333-6 pubmed
    ..Nocardia exalbida was first reported in 2006. We describe a first case of keratitis caused by Nocardia exalbida...
  8. Hong S, Han K, Son B, Shin K, Rim B. First case of Nocardia nova spinal abscess in an immunocompetent patient. Braz J Infect Dis. 2012;16:196-9 pubmed
    ..Nocardia species were isolated from intradural spinal abscesses and identified by 16S rRNA, hsp65 and secA1 sequence analyses. Surgical excision and treatment with amikacin, cefotaxime, and oral erythromycin was successful...
  9. Sullivan D, Chapman S. Bacteria that masquerade as fungi: actinomycosis/nocardia. Proc Am Thorac Soc. 2010;7:216-21 pubmed publisher
    ..Once recognized, treatment of these infections requires long courses of parenteral and oral therapy. This review will compare and contrast infections due to Actinomyces and Nocardia...
  10. Wilson J. Nocardiosis: updates and clinical overview. Mayo Clin Proc. 2012;87:403-7 pubmed publisher
    ..This review addresses the microbiology of Nocardia, risk factors for infection, clinical presentations, and management strategies...
  11. Uhde K, Pathak S, McCullum I, Jannat Khah D, Shadomy S, Dykewicz C, et al. Antimicrobial-resistant nocardia isolates, United States, 1995-2004. Clin Infect Dis. 2010;51:1445-8 pubmed publisher
    ..The species most commonly identified were N. nova (28%), N. brasiliensis (14%), and N. farcinica (14%). Of 765 isolates submitted, 61% were resistant to sulfamethoxazole and 42% were resistant to trimethoprim-sulfamethoxazole...
  12. Brown Elliott B, Biehle J, Conville P, Cohen S, Saubolle M, Sussland D, et al. Sulfonamide resistance in isolates of Nocardia spp. from a US multicenter survey. J Clin Microbiol. 2012;50:670-2 pubmed publisher
  13. Kanne J, Yandow D, Mohammed T, Meyer C. CT findings of pulmonary nocardiosis. AJR Am J Roentgenol. 2011;197:W266-72 pubmed publisher
    ..We review the various CT appearances of pulmonary nocardiosis and discuss the differential diagnosis...
  14. Magalhães G, Oliveira S, Soares A, Machado Pinto J, de Resende M. Mycetoma caused by Nocardia caviae in the first Brazilian patient. Int J Dermatol. 2010;49:56-8 pubmed publisher
    ..Infection initiation is related to local trauma and can spread to muscle, underlying bone, and adjacent organs. Nocardia brasiliensis is the most frequent actinomycete isolated, while N. caviae is a rare agent...
  15. Aboal C, Salamano R, Braselli A, Mansilla M, Galaret M, Pedreira W. [Recurrent brain abscess caused by Nocardia asteroides in a patient with primary polycythaemia]. Arq Neuropsiquiatr. 2006;64:526-9 pubmed
    ..This paper presents a patient with a primary polycythaemia and a recurrent brain abscess by Nocardia asteroides, probably of dental origin...
  16. Hashimoto M, Johkura K, Ichikawa T, Shinonaga M. Brain abscess caused by Nocardia nova. J Clin Neurosci. 2008;15:87-9 pubmed
    ..Surgical excision and antibiotic treatment of the brain abscess were successful. This is the first detailed report of central nervous system infection due to N. nova...
  17. Javadi M, Kanavi M, Zarei Ghanavati S, Zarei S, Mirbabaei F, Jamali H, et al. Outbreak of Nocardia keratitis after photorefractive keratectomy: clinical, microbiological, histopathological, and confocal scan study. J Cataract Refract Surg. 2009;35:393-8 pubmed publisher
    ..All eyes responded favorably to topical amikacin and the infection resolved without recurrence. The most probable cause of the outbreak was inadequate attention to sterility during surgery...
  18. Tsui I, Uslan D, Hubschman J, Deng S. Nocardia farcinica Infection of a Baerveldt implant and endophthalmitis in a patient with a Boston type I keratoprosthesis. J Glaucoma. 2010;19:339-40 pubmed publisher
    ..The infection resolved with aggressive surgical and medical treatment...
  19. Ribeiro M, Salerno T, Mattos Guaraldi A, Camello T, Langoni H, Siqueira A, et al. Nocardiosis: an overview and additional report of 28 cases in cattle and dogs. Rev Inst Med Trop Sao Paulo. 2008;50:177-85 pubmed
    ..otitidiscaviarum by first time in Brazil and the similarity between Nocardia species isolated from human and animal origin...
  20. Daw Garza A, Welsh O, Said Fernandez S, Lozano Garza H, Waksman de Torres N, Rocha N, et al. In vivo therapeutic effect of gatifloxacin on BALB/c mice infected with Nocardia brasiliensis. Antimicrob Agents Chemother. 2008;52:1549-50 pubmed publisher
    ..Gatifloxacin was injected subcutaneously at 100 mg/kg body weight every 8 h for 4 weeks. This compound was equally as efficient as linezolid in reducing the production of lesions...
  21. Conville P, Brown J, Steigerwalt A, Brown Elliott B, Witebsky F. Nocardia wallacei sp. nov. and Nocardia blacklockiae sp. nov., human pathogens and members of the "Nocardia transvalensis Complex". J Clin Microbiol. 2008;46:1178-84 pubmed publisher
    ..Case studies demonstrating the pathogenicity of N. wallacei and N. blacklockiae are presented. The type strain of N. wallacei is ATCC 49873 (DSM 45136), and that of N. blacklockiae is ATCC 700035 (DSM 45135)...
  22. Hansen G, Swanzy S, Gupta R, Cookson B, Limaye A. In vitro activity of fluoroquinolones against clinical isolates of Nocardia identified by partial 16S rRNA sequencing. Eur J Clin Microbiol Infect Dis. 2008;27:115-20 pubmed
    ..have several properties that make them potentially attractive candidates for the treatment of Nocardia infections, but information regarding their in vitro activity is limited...
  23. Dahan K, El Kabbaj D, Venditto M, Pastural M, Delahousse M. Intracranial Nocardia recurrence during fluorinated quinolones therapy. Transpl Infect Dis. 2006;8:161-5 pubmed
    ..It is surprising that moxifloxacin was efficient in vitro and the antimicrobial concentration in the central nervous system was high, yet the nocardial abscess recurred under this therapy...
  24. Rafiei N, Tabandeh H, Bhatti M, Monshizadeh R. Retinal fibrovascular proliferation associated with Nocardia subretinal abscess. Eur J Ophthalmol. 2006;16:641-3 pubmed
    ..To report the development of extensive fibrovascular proliferation in association with Nocardia subretinal abscess...
  25. Ramos Esteban J, Servat J, Silva R, Ambrosio R, Tauber S, Bia F. Necrotizing nocardial scleritis after combined penetrating keratoplasty and phacoemulsification with intraocular lens implantation: a case report and review of the literature. Arq Bras Oftalmol. 2007;70:355-9 pubmed
  26. Agterof M, van der Bruggen T, Tersmette M, ter Borg E, van den Bosch J, Biesma D. Nocardiosis: a case series and a mini review of clinical and microbiological features. Neth J Med. 2007;65:199-202 pubmed
    ..The diversity of clinical manifestations, microbiological identification and general principles of treatment of nocardiosis are reviewed...
  27. Kennedy K, Chung K, Bowden F, Mews P, Pik J, Fuller J, et al. A cluster of nocardial brain abscesses. Surg Neurol. 2007;68:43-9; discussion 49 pubmed
    ..Cerebral nocardiosis is an uncommon clinical entity, representing only 2% of all cerebral abscesses. It is an illness associated with significant morbidity and mortality...
  28. Ozturk S, Tufan F, Alisir S, Görçin S, Guven D, Cagatay A, et al. A case of isolated Nocardia asteroides brain abscess in a kidney transplant recipient. Transplant Proc. 2006;38:3121-4 pubmed
    ..Nocardia brain abscess is a rare condition, seen most commonly among immunocompromised patients. It may be confused with intracranial tumors and requires long-term combined antibiotic therapy after drainage...
  29. Tremblay J, Thibert L, Alarie I, Valiquette L, Pepin J. Nocardiosis in Quebec, Canada, 1988-2008. Clin Microbiol Infect. 2011;17:690-6 pubmed publisher
  30. Elmaci I, Senday D, Silav G, Ekenel F, Balak N, Ayan E, et al. Nocardial cerebral abscess associated with mycetoma, pneumonia, and membranoproliferative glomerulonephritis. J Clin Microbiol. 2007;45:2072-4 pubmed
    ..Nocardial soft tissue involvement, mycetoma, is well known. However, the fact that actinomycetoma can metastasize may not be as well appreciated. The association between nocardiosis and glomerulonephritis should be better clarified...
  31. Yu X, Han F, Wu J, He Q, Peng W, Wang Y, et al. Nocardia infection in kidney transplant recipients: case report and analysis of 66 published cases. Transpl Infect Dis. 2011;13:385-91 pubmed publisher
    ..We also review the English literature published from 1980 to 2010 and analyze the clinical characteristics of nocardiosis in kidney transplant recipients...
  32. Hardak E, Yigla M, Berger G, Sprecher H, Oren I. Clinical spectrum and outcome of Nocardia infection: experience of 15-year period from a single tertiary medical center. Am J Med Sci. 2012;343:286-90 pubmed publisher
    ..This study describes all cases of nocardial infection treated in the authors' hospital to provide more information about clinical manifestations, species isolated, treatment and outcome of patients with nocardiosis...
  33. Ambrosioni J, Lew D, Garbino J. Nocardiosis: updated clinical review and experience at a tertiary center. Infection. 2010;38:89-97 pubmed publisher
    ..We report the epidemiologic characteristics of Nocardia spp. observed in our institution and discuss the risk factors, clinical features, diagnosis, and management of the disease...
  34. Liu W, Lai C, Ko W, Chen Y, Tang H, Huang Y, et al. Clinical and microbiological characteristics of infections caused by various Nocardia species in Taiwan: a multicenter study from 1998 to 2010. Eur J Clin Microbiol Infect Dis. 2011;30:1341-7 pubmed publisher
    ..Molecular methods for identifying Nocardia to the species level are mandatory for better understanding the epidemiology and clinical characteristics of patients with nocardiosis...
  35. Ba Fall K, Mbaye M, Niang A, Faye M, Fall K, Fall B, et al. [Nocardiosis: 4 cases in Senegal]. Med Trop (Mars). 2011;71:613-4 pubmed
    ..Nocardia bacteria should be identified before starting antibiotic treatment. Patients require long-term antibiotic treatment with third generation cephalosporins or sulfamethoxazole-trimethoprim...
  36. Kong F, Wang H, Zhang E, Sintchenko V, Xiao M, Sorrell T, et al. secA1 gene sequence polymorphisms for species identification of Nocardia species and recognition of intraspecies genetic diversity. J Clin Microbiol. 2010;48:3928-34 pubmed publisher
    ..The secA1 locus has potential for species identification as an adjunct to 16S rRNA gene sequencing but requires additional deduced amino acid sequence analysis. It may be a suitable marker for phylogenetic/subtyping studies...
  37. Budzik J, Hosseini M, MacKinnon A, Taxy J. Disseminated Nocardia farcinica: literature review and fatal outcome in an immunocompetent patient. Surg Infect (Larchmt). 2012;13:163-70 pubmed publisher
    ..Nocardia farcinica is a gram-positive, partially acid-fast, methenamine silver-positive aerobic actinomycete. Nocardia spp. are opportunistic pathogens, and N. farcinica is the least common species of clinical importance...
  38. Aidê M, Lourenço S, Marchiori E, Zanetti G, Mondino P. Pulmonary nocardiosis in a patient with chronic obstructive pulmonary disease and bronchiectasis. J Bras Pneumol. 2008;34:985-8 pubmed
    ..Sputum smear microscopy and culture revealed the presence of Nocardia spp. The patient was treated with imipenem and cilastatin, which produced an excellent clinical response...
  39. Glupczynski Y, Berhin C, Janssens M, Wauters G. Determination of antimicrobial susceptibility patterns of Nocardia spp. from clinical specimens by Etest. Clin Microbiol Infect. 2006;12:905-12 pubmed
    ..Further studies on a larger number of species from more diverse geographical sources, including species that are found less commonly among clinical isolates, are required to validate and extend the results...
  40. Castro J, Espinoza L. Nocardia species infections in a large county hospital in Miami: 6 years experience. J Infect. 2007;54:358-61 pubmed
    ..There were 25 cases of nocardiosis and 76% of them were also infected with HIV. Of the HIV infected patients, all of them had CD4 counts less than 100 cells/mm(3) and most cases were localized in the lungs...
  41. Khan S, Sanche S, Robinson C, Pirouzmand F. N. paucivorans infection presenting as a brain abscess. Can J Neurol Sci. 2006;33:426-7 pubmed
  42. Nakamura S, Mihara T, Hitotsumatsu T, Soejima Y, Izumikawa K, Seki M, et al. [Case report of disseminated nocardiosis complicated in an elderly person with pneumoconiosis]. Kansenshogaku Zasshi. 2006;80:721-5 pubmed
    ..Nocardia infection is not as rare as generally assumed and should be considered as a possibility in the elderly due to its high mortality...
  43. Munoz J, Mirelis B, Aragón L, Gutierrez N, Sanchez F, Espanol M, et al. Clinical and microbiological features of nocardiosis 1997-2003. J Med Microbiol. 2007;56:545-50 pubmed
    ..Accurate identification of the species and susceptibility testing of Nocardia isolates may play an important role in diagnosis and treatment...
  44. Garg P, Sharma S, Vemuganti G, Ramamurthy B. A cluster of Nocardia keratitis after LASIK. J Refract Surg. 2007;23:309-12 pubmed
    ..To report a cluster of Nocardia asteroides keratitis cases after LASIK...
  45. Seth R, Gaudio P. Nocardia asteroides necrotizing scleritis associated with subtenon triamcinolone acetonide injection. Ocul Immunol Inflamm. 2008;16:139-40 pubmed publisher
    ..To report a case of Nocardia asteroides infection after subtenon triamcinolone acetonide injection...
  46. Baldi B, Santana A, Takagaki T. Pulmonary and cutaneous nocardiosis in a patient treated with corticosteroids. J Bras Pneumol. 2006;32:592-5 pubmed
    ..After long-term treatment with sulfamethoxazole-trimethoprim, the clinical and radiological profile improved...
  47. Tuo M, Tsai Y, Tseng H, Wang W, Liu C, Lee C. Clinical experiences of pulmonary and bloodstream nocardiosis in two tertiary care hospitals in northern Taiwan, 2000-2004. J Microbiol Immunol Infect. 2008;41:130-6 pubmed
    ..To understand the incidence, clinical characteristics, treatment and outcome of pulmonary and bloodstream nocardiosis, we conducted a retrospective study in two tertiary care hospitals in northern Taiwan...
  48. Pandya V, Petsoglou C. Nocardia transvalensis resistant to amikacin: an unusual cause of microbial keratitis. Cornea. 2008;27:1082-5 pubmed publisher
    ..To report a case of microbial keratitis caused by Nocardia transvalensis with resistance to amikacin...
  49. Lalitha P. Nocardia keratitis. Curr Opin Ophthalmol. 2009;20:318-23 pubmed publisher
    ..The purpose of this review is to discuss the recently published literature in relation to the epidemiology, cause, diagnosis, and therapy of Nocardia keratitis...
  50. Kilincer C, Hamamcioglu M, Simsek O, Hicdonmez T, Aydoslu B, Tansel O, et al. Nocardial brain abscess: review of clinical management. J Clin Neurosci. 2006;13:481-5 pubmed
    ..The clinical course, radiological findings, and management of nocardial brain abscess are discussed in light of the relevant literature, and current clinical management is reviewed through examination of the cases presented here. ..
  51. Barata C, Oliveira D, Colombo A, Pereira C. [Brain abscess caused by Nocardia sp in immunosuppressed patient]. Rev Soc Bras Med Trop. 2000;33:609-12 pubmed
    ..Diagnosis could be possible after recover secretion of peribulbar abscess and maintenance of this material over seven days in incubation. ..
  52. Braun T, Kerson L, Eisenberg F. Nocardial brain abscesses in a pregnant woman. Rev Infect Dis. 1991;13:630-2 pubmed
    ..This case illustrates the difficulty in treating a nocardial infection of the brain during pregnancy as well as the importance of achieving adequate surgical drainage of the abscesses...
  53. Beaman B, Burnside J, Edwards B, Causey W. Nocardial infections in the United States, 1972-1974. J Infect Dis. 1976;134:286-9 pubmed
    ..Between 8.6% and 18.8% of pulmonary-systemic infections in this series were caused by species of Nocardia other than N. asteroides. ..
  54. Vera Cabrera L, Gonzalez E, Choi S, Welsh O. In vitro activities of new antimicrobials against Nocardia brasiliensis. Antimicrob Agents Chemother. 2004;48:602-4 pubmed
    ..The most active drug in vitro was DA-7867, with a MIC at which 90% of the isolates tested were inhibited of 0.03 micro g/ml and a MIC at which 50% of the isolates tested were inhibited of 0.06 micro g/ml...
  55. Saubolle M, Sussland D. Nocardiosis: review of clinical and laboratory experience. J Clin Microbiol. 2003;41:4497-501 pubmed
  56. Lee L, Zaidman G, Van Horn K. Topical bactrim versus trimethoprim and sulfonamide against nocardia keratitis. Cornea. 2001;20:179-82 pubmed
    ..Recently, topical trimethoprim and sulfamethoxazole (Bactrim) has been suggested as treatment. This study compares the in vitro efficacy against Nocardia asteroides of Bactrim and various ratios of trimethoprim and a sulfonamide...
  57. Duran E, Lopez L, Martinez A, Comunas F, Boiron P, Rubio M. Primary brain abscess with Nocardia otitidiscaviarum in an intravenous drug abuser. J Med Microbiol. 2001;50:101-3 pubmed
    ..In contrast to five cases described previously the patient survived after surgical removal and antibiotic treatment with imipenem and trimethoprim-sulphamethoxazole...