tuberculosis

Summary

Summary: Any of the infectious diseases of man and other animals caused by species of MYCOBACTERIUM TUBERCULOSIS.

Top Publications

  1. McDermid J, Hennig B, Van Der Sande M, Hill A, Whittle H, Jaye A, et al. Host iron redistribution as a risk factor for incident tuberculosis in HIV infection: an 11-year retrospective cohort study. BMC Infect Dis. 2013;13:48 pubmed publisher
    Identifying people at higher risk of developing tuberculosis with human immunodeficiency virus (HIV) infection may improve clinical management of co-infections...
  2. Feasey N, Banada P, Howson W, Sloan D, Mdolo A, Boehme C, et al. Evaluation of Xpert MTB/RIF for detection of tuberculosis from blood samples of HIV-infected adults confirms Mycobacterium tuberculosis bacteremia as an indicator of poor prognosis. J Clin Microbiol. 2013;51:2311-6 pubmed publisher
    b>Tuberculosis (TB) remains a leading cause of death among HIV-infected adults, in part because of delayed diagnosis and therefore delayed initiation of treatment...
  3. Lawn S, Kerkhoff A, Vogt M, Wood R. HIV-associated tuberculosis: relationship between disease severity and the sensitivity of new sputum-based and urine-based diagnostic assays. BMC Med. 2013;11:231 pubmed publisher
    Reducing mortality from HIV-associated tuberculosis (TB) requires diagnostic tools that are rapid and have high sensitivity among patients with poor prognosis...
  4. Assam Assam J, Penlap Beng V, Cho Ngwa F, Toukam M, Ngoh A, Kitavi M, et al. Mycobacterium tuberculosis is the causative agent of tuberculosis in the southern ecological zones of Cameroon, as shown by genetic analysis. BMC Infect Dis. 2013;13:431 pubmed publisher
    b>Tuberculosis (TB) is a major cause of mortality and suffering worldwide, with over 95% of TB deaths occurring in low- and middle-income countries...
  5. Corbett E, Macpherson P. Tuberculosis screening in high human immunodeficiency virus prevalence settings: turning promise into reality. Int J Tuberc Lung Dis. 2013;17:1125-38 pubmed publisher
    Twenty years of sky-high tuberculosis (TB) incidence rates and high TB mortality in high human immunodeficiency virus (HIV) prevalence countries have so far not been matched by the same magnitude or breadth of responses as seen in malaria ..
  6. Guzzetta G, Kirschner D. The roles of immune memory and aging in protective immunity and endogenous reactivation of tuberculosis. PLoS ONE. 2013;8:e60425 pubmed publisher
    Finding more effective vaccines against tuberculosis (TB) and improved preventive treatments against endogenous reactivation of latent TB is strategic to block transmission and reach the WHO goal of eliminating TB by 2050...
  7. Lall M, Sahni A, Rajput A. Pleuropulmonary paragonimiasis: mimicker of tuberculosis. Pathog Glob Health. 2013;107:40-2 pubmed publisher
    ..Diagnosis is generally delayed due to lack of suspicion and presentation similar to tuberculosis which is endemic in the population...
  8. PEPPERELL C, Casto A, Kitchen A, Granka J, Cornejo O, Holmes E, et al. The role of selection in shaping diversity of natural M. tuberculosis populations. PLoS Pathog. 2013;9:e1003543 pubmed publisher
    Mycobacterium tuberculosis (M.tb), the cause of tuberculosis (TB), is estimated to infect a new host every second. While analyses of genetic data from natural populations of M...
  9. Lawn S, Dheda K, Kerkhoff A, Peter J, Dorman S, Boehme C, et al. Determine TB-LAM lateral flow urine antigen assay for HIV-associated tuberculosis: recommendations on the design and reporting of clinical studies. BMC Infect Dis. 2013;13:407 pubmed publisher
    Detection of the Mycobacterium tuberculosis cell wall antigen lipoarabinomannan (LAM) in urine permits diagnoses of tuberculosis (TB) to be made in HIV-infected patients with advanced immunodeficiency...

More Information

Publications134 found, 100 shown here

  1. Orr M, Fox C, Baldwin S, Sivananthan S, Lucas E, Lin S, et al. Adjuvant formulation structure and composition are critical for the development of an effective vaccine against tuberculosis. J Control Release. 2013;172:190-200 pubmed publisher
    One third of the world is infected with Mycobacterium tuberculosis (Mtb) with eight million new cases of active tuberculosis (TB) each year...
  2. Kranzer K, Afnan Holmes H, Tomlin K, Golub J, Shapiro A, Schaap A, et al. The benefits to communities and individuals of screening for active tuberculosis disease: a systematic review. Int J Tuberc Lung Dis. 2013;17:432-46 pubmed publisher
    Screening for tuberculosis (TB) disease aims to improve early TB case detection...
  3. Shukla S, Richardson E, Athman J, Shi L, Wearsch P, McDonald D, et al. Mycobacterium tuberculosis lipoprotein LprG binds lipoarabinomannan and determines its cell envelope localization to control phagolysosomal fusion. PLoS Pathog. 2014;10:e1004471 pubmed publisher
    Mycobacterium tuberculosis (Mtb) virulence is decreased by genetic deletion of the lipoprotein LprG, but the function of LprG remains unclear...
  4. Patil C, Kharat Patil R, Deshmukh P, Biswas J, John B. Primary tuberculosis of nasopharynx (adenoid)- a rare presentation. Asian Pac J Trop Med. 2013;6:246-8 pubmed publisher
    b>Tuberculosis has global presence and no part of human body is immune to it, most frequent site beings lungs...
  5. Ralph A, Ralph A, Lucas R, Norval M. Vitamin D and solar ultraviolet radiation in the risk and treatment of tuberculosis. Lancet Infect Dis. 2013;13:77-88 pubmed publisher
    Improved understanding of the association between tuberculosis and vitamin D is needed to inform clinical practice. Vitamin D has both immunostimulatory and immunosuppressive effects relevant to human antimycobacterial responses...
  6. Lönnroth K, Corbett E, Golub J, Godfrey Faussett P, Uplekar M, Weil D, et al. Systematic screening for active tuberculosis: rationale, definitions and key considerations. Int J Tuberc Lung Dis. 2013;17:289-98 pubmed publisher
    The impact of current interventions to improve early detection of tuberculosis (TB) seems to have been saturated. Case detection trends have stagnated...
  7. Baldwin S, Ching L, Pine S, Moutaftsi M, Lucas E, Vallur A, et al. Protection against tuberculosis with homologous or heterologous protein/vector vaccine approaches is not dependent on CD8+ T cells. J Immunol. 2013;191:2514-2525 pubmed publisher
    Considerable effort has been directed to develop Mycobacterium tuberculosis vaccines to boost bacille Calmette-Guérin or for those who cannot be immunized with bacille Calmette-Guérin...
  8. Jarosławski S, Pai M. Why are inaccurate tuberculosis serological tests widely used in the Indian private healthcare sector? A root-cause analysis. J Epidemiol Glob Health. 2012;2:39-50 pubmed publisher
    Serological tests for tuberculosis are inaccurate and WHO has recommended against their use. Although not used by the Revised National TB Control Programme (RNTCP), serodiagnostics are widely used in the private sector in India...
  9. Ponce M, Wysocki A, Scatolin B, Andrade R, Arakawa T, Ruffino Netto A, et al. [Tuberculosis diagnosis and performance assessment of the first health service used by patients in São José do Rio Preto, São Paulo State, Brazil]. Cad Saude Publica. 2013;29:945-54 pubmed
    This cross-sectional study aimed to analyze the first health service to which patients turned for tuberculosis diagnosis in São José do Rio Preto, São Paulo, Brazil, 2009...
  10. Tameris M, McShane H, McClain J, Landry B, Lockhart S, Luabeya A, et al. Lessons learnt from the first efficacy trial of a new infant tuberculosis vaccine since BCG. Tuberculosis (Edinb). 2013;93:143-9 pubmed publisher
    New tuberculosis (TB) vaccines are being developed to combat the global epidemic...
  11. Brouwer M, Gudo P, Simbe C, Perdigão P, van Leth F. Are routine tuberculosis programme data suitable to report on antiretroviral therapy use of HIV-infected tuberculosis patients?. BMC Res Notes. 2013;6:23 pubmed publisher
    Antiretroviral therapy (ART) is lifesaving for HIV-infected tuberculosis (TB) patients. ART-use by these patients lag behind compared to HIV-testing and co-trimoxazole preventive therapy...
  12. Tameris M, Hatherill M, Landry B, Scriba T, Snowden M, Lockhart S, et al. Safety and efficacy of MVA85A, a new tuberculosis vaccine, in infants previously vaccinated with BCG: a randomised, placebo-controlled phase 2b trial. Lancet. 2013;381:1021-8 pubmed
    BCG vaccination provides incomplete protection against tuberculosis in infants. A new vaccine, modified Vaccinia Ankara virus expressing antigen 85A (MVA85A), was designed to enhance the protective efficacy of BCG...
  13. Lugo Villarino G, Neyrolles O. Dressed not to kill: CD16+ monocytes impair immune defence against tuberculosis. Eur J Immunol. 2013;43:327-30 pubmed publisher
    ..subpopulation may represent an immune evasion strategy that ultimately favors persistence of Mycobacterium tuberculosis. Together with other recent reports, the article by Balboa et al...
  14. Ansong C, Ortega C, Payne S, Haft D, Chauvigne Hines L, LEWIS M, et al. Identification of widespread adenosine nucleotide binding in Mycobacterium tuberculosis. Chem Biol. 2013;20:123-33 pubmed publisher
    Computational prediction of protein function is frequently error-prone and incomplete. In Mycobacterium tuberculosis (Mtb), ~25% of all genes have no predicted function and are annotated as hypothetical proteins, severely limiting our ..
  15. Mihret A, Bekele Y, Aytenew M, Assefa Y, Abebe M, Wassie L, et al. Modern lineages of Mycobacterium tuberculosis in Addis Ababa, Ethiopia: implications for the tuberculosis control programe. Afr Health Sci. 2012;12:339-44 pubmed
    The genotyping of Mycobacterium tuberculosis strains is important to have unique insights into the dissemination dynamics and evolutionary genetics of this pathogen and for TB control as it allows the detection of suspected outbreaks and ..
  16. Yin X, Zheng L, Lin L, Hu Y, Zheng F, Hu Y, et al. Commercial MPT64-based tests for rapid identification of Mycobacterium tuberculosis complex: a meta-analysis. J Infect. 2013;67:369-77 pubmed publisher
    ..the accuracy of commercial MPT64-based immunochromatographic tests for rapid identification of Mycobacterium tuberculosis complex...
  17. van Laarhoven A, Mandemakers J, Kleinnijenhuis J, Enaimi M, Lachmandas E, Joosten L, et al. Low induction of proinflammatory cytokines parallels evolutionary success of modern strains within the Mycobacterium tuberculosis Beijing genotype. Infect Immun. 2013;81:3750-6 pubmed publisher
    One of the most widespread clades of Mycobacterium tuberculosis worldwide, the Beijing genotype family, consists of ancient (atypical) and modern (typical) strains...
  18. Peltzer K, Louw J. Prevalence of suicidal behaviour & associated factors among tuberculosis patients in public primary care in South Africa. Indian J Med Res. 2013;138:194-200 pubmed
    In spite of the high prevalence of tuberculosis worldwide, there are only a few studies on its psychiatric complications such as suicidal behaviour...
  19. Anderson S, Kaforou M, Brent A, Wright V, Banwell C, Chagaluka G, et al. Diagnosis of childhood tuberculosis and host RNA expression in Africa. N Engl J Med. 2014;370:1712-1723 pubmed publisher
    Improved diagnostic tests for tuberculosis in children are needed...
  20. Durovni B, Saraceni V, Moulton L, Pacheco A, Cavalcante S, King B, et al. Effect of improved tuberculosis screening and isoniazid preventive therapy on incidence of tuberculosis and death in patients with HIV in clinics in Rio de Janeiro, Brazil: a stepped wedge, cluster-randomised trial. Lancet Infect Dis. 2013;13:852-8 pubmed publisher
    Preventive therapy for tuberculosis in patients with HIV is effective, but it has not been widely implemented in moderate or high-burden settings...
  21. Laureillard D, Marcy O, Madec Y, Chea S, Chan S, Borand L, et al. Paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome after early initiation of antiretroviral therapy in a randomized clinical trial. AIDS. 2013;27:2577-86 pubmed publisher
    To analyze cases of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) in the CAMbodian Early versus Late Introduction of Antiretrovirals (CAMELIA) randomized trial designed to compare early (2 weeks)..
  22. Marinucci F, Manyazewal T, Paterniti A, Medina Moreno S, Wattleworth M, Hagembe J, et al. Impact of horizontal approach in vertical program: continuous quality improvement of malaria and tuberculosis diagnostic services at primary-level medical laboratories in the context of HIV care and treatment program in Ethiopia. Am J Trop Med Hyg. 2013;88:547-51 pubmed publisher
    ..All laboratories scored above 85% for both services at the end of interventions. ..
  23. Bonnet M, Bhatt N, Baudin E, Silva C, Michon C, Taburet A, et al. Nevirapine versus efavirenz for patients co-infected with HIV and tuberculosis: a randomised non-inferiority trial. Lancet Infect Dis. 2013;13:303-12 pubmed publisher
    In countries with a high incidence of HIV and tuberculosis co-infection, nevirapine and efavirenz are widely used as antiretroviral therapy but both interact with antituberculosis drugs...
  24. Nakanishi N, Wada T, Arikawa K, Millet J, Rastogi N, Iwamoto T. Evolutionary robust SNPs reveal the misclassification of Mycobacterium tuberculosis Beijing family strains into sublineages. Infect Genet Evol. 2013;16:174-7 pubmed publisher
    Genotypic classification in Mycobacterium tuberculosis has greatly contributed to the comprehension of phylogenetic and population genetic relationships...
  25. Naidoo P, Peltzer K, Louw J, Matseke G, McHunu G, Tutshana B. Predictors of tuberculosis (TB) and antiretroviral (ARV) medication non-adherence in public primary care patients in South Africa: a cross sectional study. BMC Public Health. 2013;13:396 pubmed publisher
    Despite the downward trend in the absolute number of tuberculosis (TB) cases since 2006 and the fall in the incidence rates since 2001, the burden of disease caused by TB remains a global health challenge...
  26. Aguilo J, Alonso H, Uranga S, Marinova D, Arbues A, De Martino A, et al. ESX-1-induced apoptosis is involved in cell-to-cell spread of Mycobacterium tuberculosis. Cell Microbiol. 2013;15:1994-2005 pubmed publisher
    ..Nevertheless, the role of apoptosis during infection with Mycobacterium tuberculosis, the causative agent of human tuberculosis, is subject of an intense debate and still remains unclear...
  27. Coleman M, Maiello P, Tomko J, Frye L, Fillmore D, Janssen C, et al. Early Changes by (18)Fluorodeoxyglucose positron emission tomography coregistered with computed tomography predict outcome after Mycobacterium tuberculosis infection in cynomolgus macaques. Infect Immun. 2014;82:2400-4 pubmed publisher
    Cynomolgus macaques infected with low-dose Mycobacterium tuberculosis develop both active tuberculosis and latent infection similar to those of humans, providing an opportunity to study the clinically silent early events in infection...
  28. Müller R, Roberts C, Brown T. Biomolecular identification of ancient Mycobacterium tuberculosis complex DNA in human remains from Britain and continental Europe. Am J Phys Anthropol. 2014;153:178-89 pubmed publisher
    b>Tuberculosis is known to have afflicted humans throughout history and re-emerged towards the end of the 20th century, to an extent that it was declared a global emergency in 1993...
  29. Sloot R, Borgdorff M, de Beer J, van Ingen J, Supply P, van Soolingen D. Clustering of tuberculosis cases based on variable-number tandem-repeat typing in relation to the population structure of Mycobacterium tuberculosis in the Netherlands. J Clin Microbiol. 2013;51:2427-31 pubmed publisher
    The population structure of 3,776 Mycobacterium tuberculosis isolates was determined using variable-number tandem-repeat (VNTR) typing. The degree of clonality was so high that a more relaxed definition of clustering cannot be applied...
  30. van Deun A, Aung K, Bola V, Lebeke R, Hossain M, de Rijk W, et al. Rifampin drug resistance tests for tuberculosis: challenging the gold standard. J Clin Microbiol. 2013;51:2633-40 pubmed publisher
    ..However, a result of rifampin susceptibility should be questioned when suspicion is very high, and further DST using a different system (i.e., genotypic after phenotypic testing) would be fully justified. ..
  31. Eklund D, Welin A, Andersson H, Verma D, Söderkvist P, Stendahl O, et al. Human gene variants linked to enhanced NLRP3 activity limit intramacrophage growth of Mycobacterium tuberculosis. J Infect Dis. 2014;209:749-53 pubmed publisher
    ..individuals to inflammatory disorders have a host-protective role during infection with Mycobacterium tuberculosis. By isolation of macrophages from patients and healthy blood donors with genetic variants in NLRP3 and CARD8 ..
  32. Nakajima C, Tamaru A, Rahim Z, Poudel A, Maharjan B, Khin Saw Aye -, et al. Simple multiplex PCR assay for identification of Beijing family Mycobacterium tuberculosis isolates with a lineage-specific mutation in Rv0679c. J Clin Microbiol. 2013;51:2025-32 pubmed publisher
    The Beijing genotype of Mycobacterium tuberculosis is known to be a worldwide epidemic clade...
  33. Simner P, Buckwalter S, Uhl J, Wengenack N. Identification of Mycobacterium species and Mycobacterium tuberculosis complex resistance determinants by use of PCR-electrospray ionization mass spectrometry. J Clin Microbiol. 2013;51:3492-8 pubmed publisher
    ..We evaluated the MDR-TB (multidrug-resistant tuberculosis) assay, which uses PCR-ESI-MS for detection and identification of Mycobacterium spp...
  34. Varghese B, Al Omari R, Grimshaw C, Al Hajoj S. Endogenous reactivation followed by exogenous re-infection with drug resistant strains, a new challenge for tuberculosis control in Saudi Arabia. Tuberculosis (Edinb). 2013;93:246-9 pubmed publisher
    Endogenous reactivation and exogenous reinfection of tuberculosis were studied for the first time in Saudi Arabia after enrolling a total of 39 patients with multiple episodes of tuberculosis between 2009 and 2010...
  35. Aabye M, Latorre I, Diaz J, Maldonado J, Mialdea I, Eugen Olsen J, et al. Dried plasma spots in the diagnosis of tuberculosis: IP-10 release assay on filter paper. Eur Respir J. 2013;42:495-503 pubmed publisher
    ..IFN)-? release assays (IGRAs) are probably the most accurate tests for the detection of latent Mycobacterium tuberculosis infection, but IGRAs are labour intensive and the transport of samples over longer distances is difficult...
  36. Owens C, Chim N, Graves A, Harmston C, Iniguez A, Contreras H, et al. The Mycobacterium tuberculosis secreted protein Rv0203 transfers heme to membrane proteins MmpL3 and MmpL11. J Biol Chem. 2013;288:21714-28 pubmed publisher
    Mycobacterium tuberculosis is the causative agent of tuberculosis, which is becoming an increasingly global public health problem due to the rise of drug-resistant strains. While residing in the human host, M...
  37. Cobat A, Hoal E, Gallant C, Simkin L, Black G, Stanley K, et al. Identification of a major locus, TNF1, that controls BCG-triggered tumor necrosis factor production by leukocytes in an area hyperendemic for tuberculosis. Clin Infect Dis. 2013;57:963-70 pubmed publisher
    Tumor necrosis factor (TNF) is a key immune regulator of tuberculosis resistance, as exemplified by the highly increased risk of tuberculosis disease among individuals receiving TNF-blocker therapy.
  38. Chen J, Zhang M, Rybniker J, Basterra L, Dhar N, Tischler A, et al. Phenotypic profiling of Mycobacterium tuberculosis EspA point mutants reveals that blockage of ESAT-6 and CFP-10 secretion in vitro does not always correlate with attenuation of virulence. J Bacteriol. 2013;195:5421-30 pubmed publisher
    The EspA protein of Mycobacterium tuberculosis is essential for the type VII ESX-1 protein secretion apparatus, which delivers the principal virulence factors ESAT-6 and CFP-10...
  39. Martinez A, Mehra S, Kaushal D. Role of interleukin 6 in innate immunity to Mycobacterium tuberculosis infection. J Infect Dis. 2013;207:1253-61 pubmed publisher
    Mycobacterium tuberculosis can grow in the hostile intracellular environment of macrophages by actively evading macrophage-associated antibacterial activities...
  40. Li C, Long J, Hu X, Zhou Y. GSTM1 and GSTT1 genetic polymorphisms and risk of anti-tuberculosis drug-induced hepatotoxicity: an updated meta-analysis. Eur J Clin Microbiol Infect Dis. 2013;32:859-68 pubmed publisher
    The results of studies investigating the associations between GSTM1 and GSTT1 polymorphisms and anti-tuberculosis drug-induced hepatotoxicity (ADIH) risk exhibit much controversy...
  41. El Daker S, Sacchi A, Montesano C, Altieri A, Galluccio G, Colizzi V, et al. An abnormal phenotype of lung V?9V?2 T cells impairs their responsiveness in tuberculosis patients. Cell Immunol. 2013;282:106-12 pubmed publisher
    ..These observations indicate that ?? T cell functions are specifically impaired in situ by active TB, suggesting that the alveolar ambient during tuberculosis may affect resident ?? T cells in comparison to circulating cells.
  42. Torrado E, Fountain J, Robinson R, Martino C, Pearl J, Rangel Moreno J, et al. Differential and site specific impact of B cells in the protective immune response to Mycobacterium tuberculosis in the mouse. PLoS ONE. 2013;8:e61681 pubmed publisher
    ..the impact of B cells in the absence of secreted immunoglobulin, we analyzed the progression of Mycobacterium tuberculosis (Mtb) infection in mice that have B cells but which lack secretory immunoglobulin (AID(-/-)µS(-/-)mice)...
  43. Bloemberg G, Voit A, Ritter C, Deggim V, Bottger E. Evaluation of Cobas TaqMan MTB for direct detection of the Mycobacterium tuberculosis complex in comparison with Cobas Amplicor MTB. J Clin Microbiol. 2013;51:2112-7 pubmed publisher
    ..Cobas TaqMan MTB assay, was one of the first commercially available assays for detection of the Mycobacterium tuberculosis complex based on nucleic acid amplification...
  44. Banada P, Koshy R, Alland D. Detection of Mycobacterium tuberculosis in blood by use of the Xpert MTB/RIF assay. J Clin Microbiol. 2013;51:2317-22 pubmed publisher
    We have developed a novel blood lysis-centrifugation approach for highly sensitive Mycobacterium tuberculosis detection in large volumes of blood with the Xpert MTB/RIF assay. One through 20 ml of blood was spiked with 0...
  45. Mhmoud N, Fahal A, Wendy van de Sande W. Association of IL-10 and CCL5 single nucleotide polymorphisms with tuberculosis in the Sudanese population. Trop Med Int Health. 2013;18:1119-1127 pubmed publisher
    To investigate the genetic determinants for developing tuberculosis in Sudan. Case study of 232 patients with tuberculosis and 206 healthy matched controls from Sudan...
  46. Buregyeya E, Nuwaha F, Verver S, Criel B, Colebunders R, Wanyenze R, et al. Implementation of tuberculosis infection control in health facilities in Mukono and Wakiso districts, Uganda. BMC Infect Dis. 2013;13:360 pubmed publisher
    b>Tuberculosis infection control (TBIC) is rarely implemented in the health facilities in resource limited settings. Understanding the reasons for low level of implementation is critical...
  47. Kirenga B, Worodria W, Massinga Loembe M, Nalwoga T, Manabe Y, Kestens L, et al. Tuberculin skin test conversion among HIV patients on antiretroviral therapy in Uganda. Int J Tuberc Lung Dis. 2013;17:336-41 pubmed publisher
    A human immunodeficiency virus (HIV) clinic in a setting of high tuberculosis (TB) and HIV prevalence...
  48. Gupta A, Wood R, Kaplan R, Bekker L, Lawn S. Prevalent and incident tuberculosis are independent risk factors for mortality among patients accessing antiretroviral therapy in South Africa. PLoS ONE. 2013;8:e55824 pubmed publisher
    Patients with prevalent or incident tuberculosis (TB) in antiretroviral treatment (ART) programmes in sub-Saharan Africa have high mortality risk...
  49. Wilson M. Rapid diagnosis of Mycobacterium tuberculosis infection and drug susceptibility testing. Arch Pathol Lab Med. 2013;137:812-9 pubmed publisher
    The global control of tuberculosis remains a challenge from the standpoint of diagnosis, detection of drug resistance, and treatment...
  50. Vignesh R, Kumarasamy N, Lim A, Solomon S, Murugavel K, Balakrishnan P, et al. TB-IRIS after initiation of antiretroviral therapy is associated with expansion of preexistent Th1 responses against Mycobacterium tuberculosis antigens. J Acquir Immune Defic Syndr. 2013;64:241-8 pubmed publisher
    The role of T-cell responses against Mycobacterium tuberculosis antigens in tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) is unclear...
  51. Ayala J, Pimienta E, Rodriguez C, Anne J, Vallin C, Milanés M, et al. Use of Strep-tag II for rapid detection and purification of Mycobacterium tuberculosis recombinant antigens secreted by Streptomyces lividans. J Microbiol Methods. 2013;94:192-8 pubmed publisher
    Recent results with respect to the secretory production of bio-active Mycobacterium tuberculosis proteins in Streptomyces have stimulated the further exploitation of this host as a bacterial cell factory...
  52. Kozakiewicz L, Phuah J, Flynn J, Chan J. The role of B cells and humoral immunity in Mycobacterium tuberculosis infection. Adv Exp Med Biol. 2013;783:225-50 pubmed publisher
    b>Tuberculosis (TB) remains a serious threat to public health, causing 2 million deaths annually world-wide...
  53. Top R, Boshuizen H, Dekkers A, Korthals Altes H. Similar seasonal peak in clustered and unique extra-pulmonary tuberculosis notifications: winter crowding hypothesis ruled out?. Int J Tuberc Lung Dis. 2013;17:1466-71 pubmed publisher
    The incidence of extra-pulmonary tuberculosis (EPTB) in the Netherlands shows a seasonal trend, with a peak in spring and a trough in autumn...
  54. Theron G, Peter J, Dowdy D, Langley I, Squire S, Dheda K. Do high rates of empirical treatment undermine the potential effect of new diagnostic tests for tuberculosis in high-burden settings?. Lancet Infect Dis. 2014;14:527-32 pubmed publisher
    In tuberculosis-endemic settings, patients are often treated empirically, meaning that they are placed on treatment based on clinical symptoms or tests that do not provide a microbiological diagnosis (eg, chest radiography)...
  55. Wong K, Jacobs W. Mycobacterium tuberculosis exploits human interferon ? to stimulate macrophage extracellular trap formation and necrosis. J Infect Dis. 2013;208:109-19 pubmed publisher
    Human neutrophils form extracellular traps during M. tuberculosis infection, but a similar phenomenon has not been reported in human macrophages. Here we demonstrate that M...
  56. Monteserin J, Camacho M, Barrera L, Palomino J, Ritacco V, Martin A. Genotypes of Mycobacterium tuberculosis in patients at risk of drug resistance in Bolivia. Infect Genet Evol. 2013;17:195-201 pubmed publisher
    Bolivia ranks among the 10 Latin American countries with the highest rates of tuberculosis (TB) and multidrug resistant (MDR) TB...
  57. Kompala T, Shenoi S, Friedland G. Transmission of tuberculosis in resource-limited settings. Curr HIV/AIDS Rep. 2013;10:264-72 pubmed publisher
    ..Infection control in community settings has been neglected and requires urgent attention. Developing and implementing improved strategies for decreasing transmission to children, within prisons and of drug-resistant TB are needed. ..
  58. Du Q, Dai G, Long Q, Yu X, Dong L, Huang H, et al. Mycobacterium tuberculosis rrs A1401G mutation correlates with high-level resistance to kanamycin, amikacin, and capreomycin in clinical isolates from mainland China. Diagn Microbiol Infect Dis. 2013;77:138-42 pubmed publisher
    Mutations correlating phenotypic resistance level with the injectable second-line anti-tuberculosis drugs (SLDs) including kanamycin (KAN), amikacin (AMK), and capreomycin (CAP) remain elusive...
  59. Bukhari S, Franzblau S, Jantan I, Jasamai M. Current prospects of synthetic curcumin analogs and chalcone derivatives against mycobacterium tuberculosis. Med Chem. 2013;9:897-903 pubmed
    b>Tuberculosis, caused by Mycobacterium tuberculosis, is amongst the foremost infectious diseases...
  60. Pasipanodya J, Gumbo T. A meta-analysis of self-administered vs directly observed therapy effect on microbiologic failure, relapse, and acquired drug resistance in tuberculosis patients. Clin Infect Dis. 2013;57:21-31 pubmed publisher
    ..We evaluated the superiority of directly observed therapy (DOT) for tuberculosis patients vs self-administered therapy (SAT) in decreasing ADR, microbiologic failure, and relapse in meta-..
  61. Verway M, Bouttier M, Wang T, Carrier M, Calderon M, An B, et al. Vitamin D induces interleukin-1? expression: paracrine macrophage epithelial signaling controls M. tuberculosis infection. PLoS Pathog. 2013;9:e1003407 pubmed publisher
    Although vitamin D deficiency is a common feature among patients presenting with active tuberculosis, the full scope of vitamin D action during Mycobacterium tuberculosis (Mtb) infection is poorly understood...
  62. Sambarey A, Prashanthi K, Chandra N. Mining large-scale response networks reveals 'topmost activities' in Mycobacterium tuberculosis infection. Sci Rep. 2013;3:2302 pubmed publisher
    Mycobacterium tuberculosis owes its high pathogenic potential to its ability to evade host immune responses and thrive inside the macrophage...
  63. Schoonmaker M, Bishai W, Lamichhane G. Nonclassical transpeptidases of Mycobacterium tuberculosis alter cell size, morphology, the cytosolic matrix, protein localization, virulence, and resistance to ?-lactams. J Bacteriol. 2014;196:1394-402 pubmed publisher
    ..Mycobacterium tuberculosis, an infectious pathogen that causes tuberculosis (TB), is known to possess as many as five proteins with L,D-..
  64. Marin N, Paris S, Rojas M, Garcia L. Functional profile of CD4+ and CD8+ T cells in latently infected individuals and patients with active TB. Tuberculosis (Edinb). 2013;93:155-66 pubmed publisher
    b>Tuberculosis (TB) is one of the most important infectious diseases around the world. Several studies have focused on the identification of correlates of protection against TB...
  65. Tompkins D, Buddle B, Whitford J, Cross M, Yates G, Lambeth M, et al. Sustained protection against tuberculosis conferred to a wildlife host by single dose oral vaccination. Vaccine. 2013;31:893-9 pubmed publisher
    Vaccination of wildlife against bovine tuberculosis (TB) is being considered by several countries to reduce the transmission of Mycobacterium bovis infection to livestock...
  66. Jiang Y, Dou X, Zhang W, Liu H, Zhao X, Wang H, et al. Genetic diversity of antigens Rv2945c and Rv0309 in Mycobacterium tuberculosis strains may reflect ongoing immune evasion. FEMS Microbiol Lett. 2013;347:77-82 pubmed publisher
    ..A previous study showed that human T-cell epitopes of Mycobacterium tuberculosis are evolutionarily hyperconserved and thus it was deduced that M...
  67. Li Q, Li J, Tian J, Zhu B, Zhang Y, Yang K, et al. IL-17 and IFN-? production in peripheral blood following BCG vaccination and Mycobacterium tuberculosis infection in human. Eur Rev Med Pharmacol Sci. 2012;16:2029-36 pubmed
    During Mycobacterium tuberculosis (Mtb) infection, cells of the immune system rely on cytokines to regulate the activity of other immune and structural cells such as IFN-gamma and IL-4...
  68. Schön T, Lerm M, Stendahl O. Shortening the 'short-course' therapy- insights into host immunity may contribute to new treatment strategies for tuberculosis. J Intern Med. 2013;273:368-82 pubmed publisher
    Achieving global control of tuberculosis (TB) is a great challenge considering the current increase in multidrug resistance and mortality rate...
  69. Tessema B, Beer J, Merker M, Emmrich F, Sack U, Rodloff A, et al. Molecular epidemiology and transmission dynamics of Mycobacterium tuberculosis in Northwest Ethiopia: new phylogenetic lineages found in Northwest Ethiopia. BMC Infect Dis. 2013;13:131 pubmed publisher
    Although Ethiopia ranks seventh among the world's 22 high-burden tuberculosis (TB) countries, little is known about strain diversity and transmission...
  70. Hales C, Heilig C, Chaisson R, Leung C, Chang K, Goldberg S, et al. The association between symptoms and microbiologically defined response to tuberculosis treatment. Ann Am Thorac Soc. 2013;10:18-25 pubmed publisher
    The lack of consistent associations between clinical outcomes and microbiological responses to therapy for some infectious diseases has raised questions about the adequacy of microbiological endpoints for tuberculosis treatment trials.
  71. McNairy M, Howard A, El Sadr W. Antiretroviral therapy for prevention of HIV and tuberculosis: a promising intervention but not a panacea. J Acquir Immune Defic Syndr. 2013;63 Suppl 2:S200-7 pubmed publisher
    ..In addition, evidence of the possible effect of use of ART on decreasing the incidence of tuberculosis (TB) in persons living with HIV has also contributed further enthusiasm...
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    Japan Anti-Tuberculosis Association (JATA) (12)-variable numbers of tandem repeats (VNTR) is a standard method for genotyping of clinical isolates of Mycobacterium tuberculosis in Japan...
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    ..b>Tuberculosis (TB) drug discovery and biology follow the same pattern...
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    The prevention of tuberculosis (TB) transmission in healthcare settings is a major issue, particularly because of the interaction between human immunodeficiency virus and TB and the emergence of multidrug-resistant TB.
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    This cohort study utilized data from a large HIV treatment program in western Kenya to describe the impact of active tuberculosis (TB) on clinical outcomes among African patients on antiretroviral therapy (ART).
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    Mycobacterial interspersed repetitive units (MIRUs) are minisatellites within the Mycobacterium tuberculosis (Mtb) genome...
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    b>Tuberculosis (TB) is a major public health problem globally. Little is known about TB incidence in adolescents who are a proposed target group for new TB vaccines...
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    ..However, limited information is available on the prevalence and outcomes of cryptococcal antigenemia among hospitalized HIV-seropositive patients in sub-Saharan Africa...
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    ..To investigate the pharmacokinetics of artemether, dihydroartemisinin and lumefantrine during rifampicin intake and after stopping rifampicin...
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    b>Tuberculosis caused 20% of all human deaths in the Western world between the seventeenth and nineteenth centuries and remains a cause of high mortality in developing countries...
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    To assess whether Interferon-? release assays (IGRAs) reduce the number of people considered for tuberculosis (TB) preventive treatment without increasing subsequent active disease.
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    ..There was a B-cell epitope for CE and ESAT-6 protein in the position 40 to 62 of ESAT-6. E5 peptide may be useful in the serodiagnosis of tuberculosis, which need to be further confirmed by more sera samples.
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    The dosage of 10 mg/kg/d rifampin, as currently used in the treatment of tuberculosis (TB), is not an optimal dose. Shortening of treatment duration might be achievable using an increased rifampin dose.
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    Despite the improvements in the global fight against tuberculosis (TB), critical points still remain and fuel the epidemic...
  85. Donoghue H. Insights into ancient leprosy and tuberculosis using metagenomics. Trends Microbiol. 2013;21:448-50 pubmed publisher
    Leprosy and tuberculosis were widespread in the past and remain significant diseases today...
  86. Banu S, Rahman S, Khan M, Ferdous S, Ahmed S, Gratz J, et al. Discordance across several methods for drug susceptibility testing of drug-resistant Mycobacterium tuberculosis isolates in a single laboratory. J Clin Microbiol. 2014;52:156-63 pubmed publisher
    Given the increases in drug-resistant tuberculosis, laboratory capacities for drug susceptibility testing are being scaled up worldwide. A laboratory must decide among several endorsed methodologies...
  87. Carter S, Chambers M, Rushton S, Shirley M, Schuchert P, Pietravalle S, et al. BCG vaccination reduces risk of tuberculosis infection in vaccinated badgers and unvaccinated badger cubs. PLoS ONE. 2012;7:e49833 pubmed publisher
    Wildlife is a global source of endemic and emerging infectious diseases. The control of tuberculosis (TB) in cattle in Britain and Ireland is hindered by persistent infection in wild badgers (Meles meles)...
  88. Ritz N, Mui M, Balloch A, Curtis N. Non-specific effect of Bacille Calmette-Guérin vaccine on the immune response to routine immunisations. Vaccine. 2013;31:3098-103 pubmed publisher
    ..In addition to protection against tuberculosis (TB), evidence suggests that BCG immunisation has a number of additional beneficial non-specific immunological ..
  89. Puri R, Reddy P, Tyagi A. Secreted acid phosphatase (SapM) of Mycobacterium tuberculosis is indispensable for arresting phagosomal maturation and growth of the pathogen in guinea pig tissues. PLoS ONE. 2013;8:e70514 pubmed publisher
    b>Tuberculosis (TB) is responsible for nearly 1.4 million deaths globally every year and continues to remain a serious threat to human health...
  90. Schwartz A, Tamuhla N, Steenhoff A, Nkakana K, Letlhogile R, Chadborn T, et al. Outcomes in HIV-infected adults with tuberculosis at clinics with and without co-located HIV clinics in Botswana. Int J Tuberc Lung Dis. 2013;17:1298-303 pubmed publisher
    ..Gaborone, Botswana...
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    For the first time in decades, there are multiple new drugs in the pipeline for the treatment of tuberculosis (TB)...