paratuberculosis

Summary

Summary: A chronic GASTROENTERITIS in RUMINANTS caused by MYCOBACTERIUM AVIUM SUBSPECIES PARATUBERCULOSIS.

Top Publications

  1. Koets A, Santema W, Mertens H, Oostenrijk D, Keestra M, Overdijk M, et al. Susceptibility to paratuberculosis infection in cattle is associated with single nucleotide polymorphisms in Toll-like receptor 2 which modulate immune responses against Mycobacterium avium subspecies paratuberculosis. Prev Vet Med. 2010;93:305-15 pubmed publisher
    b>Paratuberculosis is a chronic intestinal infection in ruminants, caused by Mycobacterium avium subspecies paratuberculosis (Map)...
  2. Click R, Van Kampen C. Comparison of ante-mortem assays to assess progression/regression of paratuberculosis in individual dairy animals. Virulence. 2010;1:134-44 pubmed publisher
    Johne's disease, caused by Mycobacterium avium, subspecies paratuberculosis (MAP) is becoming increasingly widespread on dairy farms worldwide, due in part, to the absence of vaccine/drug or curative modalities...
  3. Zhang M, Zhang S. An efficient DNA extraction method for polymerase chain reaction-based detection of Mycobacterium avium subspecies paratuberculosis in bovine fecal samples. J Vet Diagn Invest. 2011;23:41-8 pubmed
    Due to the lipid rich cell wall of Mycobacterium avium subspecies paratuberculosis (MAP), the complex nature of bovine feces, and intermittent organism shedding by infected cattle, it is difficult to recover a sufficient amount of high-..
  4. Wynne J, Bull T, Seemann T, Bulach D, Wagner J, Kirkwood C, et al. Exploring the zoonotic potential of Mycobacterium avium subspecies paratuberculosis through comparative genomics. PLoS ONE. 2011;6:e22171 pubmed publisher
    A comparative genomics approach was utilised to compare the genomes of Mycobacterium avium subspecies paratuberculosis (MAP) isolated from early onset paediatric Crohn's disease (CD) patients as well as Johne's diseased animals...
  5. Lamont E, Sreevatsan S. Paradigm redux--Mycobacterium avium subspecies paratuberculosis-macrophage interactions show clear variations between bovine and human physiological body temperatures. Microb Pathog. 2010;48:143-9 pubmed publisher
    ..Current in vitro models investigating host-pathogen interactions of Mycobacterium avium subsp. paratuberculosis use 37 degrees C, the normal body temperatures of mice and humans...
  6. Stringer L, Wilson P, Heuer C, Hunnam J, Mackintosh C. Effect of vaccination and natural infection with Mycobacterium avium subsp. paratuberculosis on specificity of diagnostic tests for bovine tuberculosis in farmed red deer (Cervus elaphus). N Z Vet J. 2011;59:218-24 pubmed publisher
    To assess the effect of vaccination against paratuberculosis (Johne's disease) on reactivity to diagnostic tests for bovine tuberculosis (Tb) in deer exposed to natural challenge with Mycobacterium avium subsp...
  7. Kralik P, Beran V, Pavlik I. Enumeration of Mycobacterium avium subsp. paratuberculosis by quantitative real-time PCR, culture on solid media and optical densitometry. BMC Res Notes. 2012;5:114 pubmed publisher
    Different approaches are used for determining the number of Mycobacterium avium subsp. paratuberculosis (MAP) cells in a suspension...
  8. Lamont E, Xu W, Sreevatsan S. Host-Mycobacterium avium subsp. paratuberculosis interactome reveals a novel iron assimilation mechanism linked to nitric oxide stress during early infection. BMC Genomics. 2013;14:694 pubmed publisher
    ..The purpose of this study was to create a host-Mycobacterium avium subsp. paratuberculosis (MAP) interactome for early infection in an epithelium-macrophage co-culture system using RNA-seq...
  9. Park K, Allen A, Bannantine J, Seo K, Hamilton M, Abdellrazeq G, et al. Evaluation of two mutants of Mycobacterium avium subsp. paratuberculosis as candidates for a live attenuated vaccine for Johne's disease. Vaccine. 2011;29:4709-19 pubmed publisher
    Control of Johne's disease, caused by Mycobacterium avium subsp. paratuberculosis, has been difficult because of a lack of an effective vaccine...

More Information

Publications104 found, 100 shown here

  1. Masala S, Paccagnini D, Cossu D, Brezar V, Pacifico A, Ahmed N, et al. Antibodies recognizing Mycobacterium avium paratuberculosis epitopes cross-react with the beta-cell antigen ZnT8 in Sardinian type 1 diabetic patients. PLoS ONE. 2011;6:e26931 pubmed publisher
    ..Mycobacterium avium subspecies paratuberculosis (MAP) is transmitted from dairy herds to humans through food contamination...
  2. Sorge U, Kurnick S, Sreevatsan S. Detection of Mycobacterium avium subspecies paratuberculosis in the saliva of dairy cows: a pilot study. Vet Microbiol. 2013;164:383-6 pubmed publisher
    ..b>paratuberculosis (MAP). Transmission of MAP occurs predominately through feces, colostrum and milk...
  3. Okura H, Nielsen S, Toft N. Prevalence of Mycobacterium avium subsp. paratuberculosis infection in adult Danish non-dairy cattle sampled at slaughter. Prev Vet Med. 2010;94:185-90 pubmed publisher
    A voluntary, risk-based control program for paratuberculosis in dairy herds was started in 2006 in Denmark. The program does not include non-dairy herds, and the occurrence of Mycobacterium avium subsp...
  4. Clark R, Griffin J, Mackintosh C. Johne's disease caused by Mycobacterium avium subsp. paratuberculosis infection in red deer (Cervus elaphus): an histopathological grading system, and comparison of paucibacillary and multibacillary disease. N Z Vet J. 2010;58:90-7 pubmed publisher
    ..b>paratuberculosis (MAP), and report the distribution of granulomas and findings seen in paucibacillary and multibacillary forms ..
  5. Brujeni G, Gharibi D. Development of DNA-designed avian IgY antibodies for detection of Mycobacterium avium subsp. paratuberculosis heat shock protein 70 (Hsp70) and anti-Hsp70 antibodies in the serum of normal cattle. Appl Biochem Biotechnol. 2012;167:14-23 pubmed publisher
    Mycobacterium avium subsp. paratuberculosis heat shock protein 70 (MAPHsp70) is an immunodominant antigen, which can be used as a subunit vaccine against bovine paratuberculosis...
  6. Manning E. Paratuberculosis in captive and free-ranging wildlife. Vet Clin North Am Food Anim Pract. 2011;27:621-30, vii pubmed publisher
    ..b>paratuberculosis (MAP) infection. Young ruminants are the most prone to infection through fecal-oral transmission...
  7. Watkins C, Schock A, May L, Denham S, Sales J, Welch L, et al. Assessing virulence of vaccine strains of Mycobacterium avium subspecies paratuberculosis in a calf model. Vet Microbiol. 2010;146:63-9 pubmed publisher
    The purpose of this investigation was to characterise the virulence of two Mycobacterium avium subspecies paratuberculosis (M.a...
  8. Cossu D, Cocco E, Paccagnini D, Masala S, Ahmed N, Frau J, et al. Association of Mycobacterium avium subsp. paratuberculosis with multiple sclerosis in Sardinian patients. PLoS ONE. 2011;6:e18482 pubmed publisher
    Mycobacterium avium subsp. paratuberculosis (MAP) infection is highly spread in the ruminant herds of Sardinia, in the Western Mediterranean...
  9. Marfell B, O Brien R, Griffin J. Global gene expression profiling of monocyte-derived macrophages from red deer (Cervus elaphus) genotypically resistant or susceptible to Mycobacterium avium subspecies paratuberculosis infection. Dev Comp Immunol. 2013;40:210-7 pubmed publisher
    Mycobacterium avium subspecies paratuberculosis (MAP) can cause a chronic inflammatory bowel disease, Johne's disease (JD), in ruminant animals...
  10. Faisal S, Yan F, Chen T, Useh N, Guo S, Yan W, et al. Evaluation of a Salmonella vectored vaccine expressing Mycobacterium avium subsp. paratuberculosis antigens against challenge in a goat model. PLoS ONE. 2013;8:e70171 pubmed publisher
    Johnes disease (JD), caused by Mycobacterium avium subsp paratuberculosis (MAP), occurs worldwide as chronic granulomatous enteritis of domestic and wild ruminants...
  11. Forde T, Kutz S, De Buck J, Warren A, Ruckstuhl K, Pybus M, et al. Occurrence, diagnosis, and strain typing of Mycobacterium avium subspecies paratuberculosis infection in Rocky Mountain bighorn sheep (Ovis canadensis canadensis) in southwestern Alberta. J Wildl Dis. 2012;48:1-11 pubmed
    The role that wildlife may play in the transmission of Mycobacterium avium subspecies paratuberculosis (Map), the causative agent of Johne's disease (JD), and the potential consequences of infection in these populations are being given ..
  12. Subharat S, Shu D, Wedlock D, Price Carter M, de Lisle G, Luo D, et al. Immune responses associated with progression and control of infection in calves experimentally challenged with Mycobacterium avium subsp. paratuberculosis. Vet Immunol Immunopathol. 2012;149:225-36 pubmed publisher
    ..b>paratuberculosis (MAP) infection in calves...
  13. Bower K, Begg D, Whittington R. Optimisation of culture of Mycobacterium avium subspecies paratuberculosis from blood samples. J Microbiol Methods. 2010;80:93-9 pubmed publisher
    Mycobacterium avium subspecies paratuberculosis (MAP) is the causative agent of Johne's disease or paratuberculosis, a chronic enteritis of ruminants, and has been suggested to play a role in Crohn's disease in humans...
  14. Stief B, Möbius P, Türk H, Hörügel U, Arnold C, Pöhle D. [Paratuberculosis in a miniature donkey (Equus asinus f. asinus)]. Berl Munch Tierarztl Wochenschr. 2012;125:38-44 pubmed
    b>Paratuberculosis is mainly an infectious disease of ruminants with worldwide distribution. Infection occurs in early stages of life...
  15. Neibergs H, Settles M, Whitlock R, Taylor J. GSEA-SNP identifies genes associated with Johne's disease in cattle. Mamm Genome. 2010;21:419-25 pubmed publisher
    ..The objective of this study was to identify modest-effect genes associated with Mycobacterium avium subsp. paratuberculosis (Map) tissue infection or fecal shedding using GSEA-SNP applied to KEGG pathways or Gene Ontology (GO) gene ..
  16. Patton E. Paratuberculosis vaccination. Vet Clin North Am Food Anim Pract. 2011;27:573-80, vi pubmed publisher
    ..The vaccine reduces clinical disease and fecal shedding of Mycobacterium avium subsp. paratuberculosis (MAP)...
  17. van Hulzen K, Schopen G, van Arendonk J, Nielen M, Koets A, Schrooten C, et al. Genome-wide association study to identify chromosomal regions associated with antibody response to Mycobacterium avium subspecies paratuberculosis in milk of Dutch Holstein-Friesians. J Dairy Sci. 2012;95:2740-8 pubmed publisher
    ..the Netherlands were analyzed to obtain sire estimated breeding values for Mycobacterium avium subspecies paratuberculosis (MAP)-specific antibody response in milk using a sire-maternal grandsire model with fixed effects for parity, ..
  18. Hoek A, Rutten V, van der Zee R, Davies C, Koets A. Epitopes of Mycobacterium avium ssp. paratuberculosis 70kDa heat-shock protein activate bovine helper T cells in outbred cattle. Vaccine. 2010;28:5910-9 pubmed publisher
    The recombinant 70kDa heat-shock protein of Mycobacterium avium subspecies paratuberculosis (MAP Hsp70) has been shown to be an immunodominant antigen and a subunit vaccine candidate for bovine paratuberculosis...
  19. Collins M. Diagnosis of paratuberculosis. Vet Clin North Am Food Anim Pract. 2011;27:581-91, vi pubmed publisher
    ..The challenge is to be clear on the purpose for testing and then use the diagnostic test appropriate to that purpose for the specific animal species or type of business. ..
  20. MacHugh D, Taraktsoglou M, Killick K, Nalpas N, Browne J, DE Park S, et al. Pan-genomic analysis of bovine monocyte-derived macrophage gene expression in response to in vitro infection with Mycobacterium avium subspecies paratuberculosis. Vet Res. 2012;43:25 pubmed publisher
    Mycobacterium avium subspecies paratuberculosis is the causative agent of Johne's disease, an intestinal disease of ruminants with major economic consequences...
  21. Mortier R, Barkema H, Bystrom J, Illanes O, Orsel K, Wolf R, et al. Evaluation of age-dependent susceptibility in calves infected with two doses of Mycobacterium avium subspecies paratuberculosis using pathology and tissue culture. Vet Res. 2013;44:94 pubmed publisher
    ..assumption that calves of more than 6 months of age are more resistant to Mycobacterium avium subspecies paratuberculosis (MAP) infection has recently been challenged...
  22. Kirkpatrick B, Shook G. Genetic susceptibility to paratuberculosis. Vet Clin North Am Food Anim Pract. 2011;27:559-71, vi pubmed publisher
    ..Multiple studies indicate that host animal genetics play a role in susceptibility to Mycobacterium avium subsp. paratuberculosis (MAP) infection...
  23. Pérez de Val B, Nofrarias M, López Soria S, Garrido J, Vordermeier H, Villarreal Ramos B, et al. Effects of vaccination against paratuberculosis on tuberculosis in goats: diagnostic interferences and cross-protection. BMC Vet Res. 2012;8:191 pubmed publisher
    ..However, vaccination against paratuberculosis (PTB) in goats is often allowed even when its effect on TB diagnosis has not been fully evaluated...
  24. Casas E, Garcia M, Wells J, Smith T. Association of single nucleotide polymorphisms in the ANKRA2 and CD180 genes with bovine respiratory disease and presence of Mycobacterium avium subsp. paratuberculosis(1). Anim Genet. 2011;42:571-7 pubmed publisher
    ..b>paratuberculosis (MAP) in cattle. Two independent populations were used...
  25. Delgado L, Juste R, Munoz M, Morales S, Benavides J, Ferreras M, et al. Differences in the peripheral immune response between lambs and adult ewes experimentally infected with Mycobacterium avium subspecies paratuberculosis. Vet Immunol Immunopathol. 2012;145:23-31 pubmed publisher
    ..young lambs and adult ewes experimentally infected with two different doses of Mycobacterium avium subspecies paratuberculosis (Map). Sixteen 1...
  26. Nielsen S, Toft N. Effect of days in milk and milk yield on testing positive in milk antibody ELISA to Mycobacterium avium subsp. paratuberculosis in dairy cattle. Vet Immunol Immunopathol. 2012;149:6-10 pubmed publisher
    ..b>paratuberculosis (MAP)...
  27. Nielsen S, Toft N. Effect of management practices on paratuberculosis prevalence in Danish dairy herds. J Dairy Sci. 2011;94:1849-57 pubmed publisher
    A voluntary risk-based control program on paratuberculosis in dairy cattle was initiated in Denmark in 2006...
  28. Elze J, Liebler Tenorio E, Ziller M, Kohler H. Comparison of prevalence estimation of Mycobacterium avium subsp. paratuberculosis infection by sampling slaughtered cattle with macroscopic lesions vs. systematic sampling. Epidemiol Infect. 2013;141:1536-44 pubmed publisher
    ..b>paratuberculosis (MAP) infection in clinically healthy slaughtered cattle...
  29. Giangaspero M, Bonfini B, Orusa R, Savini G, Osawa T, Harasawa R. Epidemiological survey for Toxoplasma gondii, Chlamydia psittaci var. ovis, Mycobacterium paratuberculosis, Coxiella burnetii, Brucella spp., leptospirosis and Orf virus among sheep from northern districts of Japan. J Vet Med Sci. 2013;75:679-84 pubmed
    ..ovis, Mycobacterium paratuberculosis, Coxiella burnetii, Brucella spp., Leptospirosis and Orf virus (ORFV)...
  30. Pribylova R, Slana I, Kaevska M, Lamka J, Babak V, Jandak J, et al. Soil and plant contamination with Mycobacterium avium subsp. paratuberculosis after exposure to naturally contaminated mouflon feces. Curr Microbiol. 2011;62:1405-10 pubmed publisher
    The aim of this study was to demonstrate the persistence of Mycobacterium avium subsp. paratuberculosis (MAP) in soil and colonization of different plant parts after deliberate exposure to mouflon feces naturally contaminated with ..
  31. Mackintosh C, Clark R, Thompson B, Tolentino B, Griffin J, de Lisle G. Age susceptibility of red deer (Cervus elaphus) to paratuberculosis. Vet Microbiol. 2010;143:255-61 pubmed publisher
    ..b>paratuberculosis (MAP) after experimental oral challenge...
  32. Ruiz Larra aga O, Manzano C, Iriondo M, Garrido J, Molina E, Vazquez P, et al. Genetic variation of toll-like receptor genes and infection by Mycobacterium avium ssp. paratuberculosis in Holstein-Friesian cattle. J Dairy Sci. 2011;94:3635-41 pubmed publisher
    ..In cattle, 3 members of the TLR family, TLR1, TLR2, and TLR4, are associated with Mycobacterium avium ssp. paratuberculosis infection, although the extent of this association for the TLR1 and TLR4 receptors has not yet been ..
  33. Faisal S, Chen J, Yan F, Chen T, Useh N, Yan W, et al. Evaluation of a Mycobacterium avium subsp. paratuberculosis leuD mutant as a vaccine candidate against challenge in a caprine model. Clin Vaccine Immunol. 2013;20:572-81 pubmed publisher
    ..avium subsp. paratuberculosis in a caprine colonization model...
  34. Dennis M, Reddacliff L, Whittington R. Longitudinal study of clinicopathological features of Johne's disease in sheep naturally exposed to Mycobacterium avium subspecies paratuberculosis. Vet Pathol. 2011;48:565-75 pubmed publisher
    ..Six of the 46 (8.7%) biopsy-culture-positive sheep later had negative cultures at necropsy, suggesting recovery from infection. Further study is needed to identify factors associated with clearance of infection or progression of disease...
  35. Vazquez P, Garrido J, Juste R. Specific antibody and interferon-gamma responses associated with immunopathological forms of bovine paratuberculosis in slaughtered Friesian cattle. PLoS ONE. 2013;8:e64568 pubmed publisher
    Mycobacterium avium subsp. paratuberculosis (MAP) infection causes a chronic granulomatous inflammatory regional enteritis in ruminants...
  36. Smith R, Strawderman R, Schukken Y, Wells S, Pradhan A, Espejo L, et al. Effect of Johne's disease status on reproduction and culling in dairy cattle. J Dairy Sci. 2010;93:3513-24 pubmed publisher
    Among the costs attributed to Mycobacterium avium ssp. paratuberculosis (MAP) infection in dairy cattle, the effects on reproduction and culling are the least documented...
  37. Weber M, Kogut J, de Bree J, van Schaik G, Nielen M. Age at which dairy cattle become Mycobacterium avium subsp. paratuberculosis faecal culture positive. Prev Vet Med. 2010;97:29-36 pubmed publisher
    Age at which cattle become faecal culture positive for Mycobacterium avium subsp. paratuberculosis (Map) can be used as a proxy parameter for age at onset of faecal shedding, which is an important parameter in the control of Map in cattle ..
  38. Bannantine J, Talaat A. Genomic and transcriptomic studies in Mycobacterium avium subspecies paratuberculosis. Vet Immunol Immunopathol. 2010;138:303-11 pubmed publisher
    ..With the complete genome sequence of a bovine isolate of M. avium subspecies paratuberculosis, and the independent construction of DNA microarrays in our laboratories, transcriptomic studies for this ..
  39. Timms V, Gehringer M, Mitchell H, Daskalopoulos G, Neilan B. How accurately can we detect Mycobacterium avium subsp. paratuberculosis infection?. J Microbiol Methods. 2011;85:1-8 pubmed publisher
    Mycobacteria have thwarted detection by scientists for centuries. Mycobacterium paratuberculosis is one of the most fastidious of the Mycobacteriaceae, and has been implicated in both animal and human diseases. In domestic livestock, M...
  40. Alonso Hearn M, Molina E, Geijo M, Vazquez P, Sevilla I, Garrido J, et al. Immunization of adult dairy cattle with a new heat-killed vaccine is associated with longer productive life prior to cows being sent to slaughter with suspected paratuberculosis. J Dairy Sci. 2012;95:618-29 pubmed publisher
    The objective of this study was to evaluate the efficacy of a new heat-killed Mycobacterium avium ssp. paratuberculosis (MAP) vaccine for control of premature culling in tuberculosis-free dairy cattle...
  41. Cho J, Tauer L, Schukken Y, Gomez M, Smith R, Lu Z, et al. Economic analysis of Mycobacterium avium subspecies paratuberculosis vaccines in dairy herds. J Dairy Sci. 2012;95:1855-72 pubmed publisher
    Johne's disease, or paratuberculosis, is a chronic infectious enteric disease of ruminants, caused by infection with Mycobacterium avium ssp. paratuberculosis (MAP)...
  42. Sweeney R, Collins M, Koets A, McGuirk S, Roussel A. Paratuberculosis (Johne's disease) in cattle and other susceptible species. J Vet Intern Med. 2012;26:1239-50 pubmed publisher
    b>Paratuberculosis (Johne's disease) is a widespread and costly disease. This consensus statement will summarize recommendations regarding diagnosis, control, and treatment of Johne's disease in cattle and other species...
  43. Bhattarai B, Fosgate G, Osterstock J, Fossler C, Park S, Roussel A. Comparison of calf weaning weight and associated economic variables between beef cows with and without serum antibodies against or isolation from feces of Mycobacterium avium subsp paratuberculosis. J Am Vet Med Assoc. 2013;243:1609-15 pubmed publisher
    ..and associated economic variables for beef cows with serum antibodies against Mycobacterium avium subsp paratuberculosis (MAP) or from which MAP was isolated from feces with those for cows that were seronegative for antibodies ..
  44. Pant S, Schenkel F, Verschoor C, You Q, Kelton D, Moore S, et al. A principal component regression based genome wide analysis approach reveals the presence of a novel QTL on BTA7 for MAP resistance in holstein cattle. Genomics. 2010;95:176-82 pubmed publisher
    Bovine Johne's disease (JD), caused by Mycobacterium avium spp. paratuberculosis (MAP), causes significant losses to the dairy and beef cattle industries...
  45. Nielsen S, Toft N, Gardner I. Structured approach to design of diagnostic test evaluation studies for chronic progressive infections in animals. Vet Microbiol. 2011;150:115-25 pubmed publisher
    ..The process is illustrated by two examples of Mycobacterium avium subsp. paratuberculosis (MAP) infections in cattle...
  46. Purkhart R, Köhler H, Liebler Tenorio E, Meyer M, Becher G, Kikowatz A, et al. Chronic intestinal Mycobacteria infection: discrimination via VOC analysis in exhaled breath and headspace of feces using differential ion mobility spectrometry. J Breath Res. 2011;5:027103 pubmed publisher
    ..consisted of two groups of goats orally infected with two different doses of Mycobacterium avium subspecies paratuberculosis (MAP) and one group of non-infected healthy controls (each group: n = 6)...
  47. Borrmann E, Möbius P, Diller R, Köhler H. Divergent cytokine responses of macrophages to Mycobacterium avium subsp. paratuberculosis strains of Types II and III in a standardized in vitro model. Vet Microbiol. 2011;152:101-11 pubmed publisher
    Based on epidemiological and clinical observations, different strains of Mycobacterium avium subsp. paratuberculosis (MAP) are suspected to significantly differ in their virulence for ruminants...
  48. Logar K, Kopinč R, Bandelj P, Starič J, Lapanje A, Ocepek M. Evaluation of combined high-efficiency DNA extraction and real-time PCR for detection of Mycobacterium avium subsp. paratuberculosis in subclinically infected dairy cattle: comparison with faecal culture, milk real-time PCR and milk ELISA. BMC Vet Res. 2012;8:49 pubmed publisher
    Johne's disease is caused by Mycobacterium avium subsp. paratuberculosis (Map) and it is one of the most important diseases in cattle worldwide...
  49. Dobson B, Liggett S, O Brien R, Griffin J. Innate immune markers that distinguish red deer (Cervus elaphus) selected for resistant or susceptible genotypes for Johne's disease. Vet Res. 2013;44:5 pubmed publisher
    ..inflammatory bowel disease affecting ruminants and is caused by infection with Mycobacterium avium subspecies paratuberculosis (MAP)...
  50. Favila Humara L, Chávez Gris G, Carrillo Casas E, Hernández Castro R. Mycobacterium avium subsp. paratuberculosis detection in individual and bulk tank milk samples from bovine herds and caprine flocks. Foodborne Pathog Dis. 2010;7:351-5 pubmed publisher
    b>Paratuberculosis, or Johne's disease, is caused by Mycobacterium avium subsp. paratuberculosis (Map), and it generates great economic losses for the dairy industry worldwide. In humans, Map has been associated with Crohn's disease...
  51. Gillan S, O Brien R, Hughes A, Griffin J. Identification of immune parameters to differentiate disease states among sheep infected with Mycobacterium avium subsp. paratuberculosis. Clin Vaccine Immunol. 2010;17:108-17 pubmed publisher
    Johne's disease, a chronic enteritis of ruminants, is caused by infection with Mycobacterium avium subsp. paratuberculosis. Three distinct forms have been observed in sheep: paucibacillary disease (PB), multibacillary disease (MB), and ..
  52. Gaukler S, Linz G, Sherwood J, Dyer N, Bleier W, Wannemuehler Y, et al. Escherichia coli, Salmonella, and Mycobacterium avium subsp. paratuberculosis in wild European starlings at a Kansas cattle feedlot. Avian Dis. 2009;53:544-51 pubmed
    The prevalence of Escherichia coli, Salmonella spp., and Mycobacterium avium subsp. paratuberculosis isolated from the feces of wild European starlings (Sturnus vulgaris) humanely trapped at a feedlot in central Kansas was assessed. All E...
  53. Sorge U, Lissemore K, Godkin A, Hendrick S, Wells S, Kelton D. Associations between paratuberculosis milk ELISA result, milk production, and breed in Canadian dairy cows. J Dairy Sci. 2011;94:754-61 pubmed publisher
    The 3 objectives of this study were (1) to quantify milk production differences among cows with different paratuberculosis (ParaTB) milk ELISA results; (2) to determine if production differences existed in lactations preceding the test ..
  54. Davis W, Madsen Bouterse S. Crohn's disease and Mycobacterium avium subsp. paratuberculosis: the need for a study is long overdue. Vet Immunol Immunopathol. 2012;145:1-6 pubmed publisher
    The initial suggestion that Mycobacterium avium subsp. paratuberculosis (Map) might be involved in the pathogenesis of Crohn's disease (CD) was based on the apparent similarity of lesions in the intestine of patients with CD with those ..
  55. Roderfeld M, Koc A, Rath T, Blöcher S, Tschuschner A, Akineden O, et al. Induction of matrix metalloproteinases and TLR2 and 6 in murine colon after oral exposure to Mycobacterium avium subsp. paratuberculosis. Microbes Infect. 2012;14:545-53 pubmed publisher
    Mycobacterium avium subspecies paratuberculosis (MAP) is suspected to be a causative agent in Crohn's disease...
  56. Kupper J, Brandt H, Donat K, Erhardt G. Heritability estimates for Mycobacterium avium subspecies paratuberculosis status of German Holstein cows tested by fecal culture. J Dairy Sci. 2012;95:2734-9 pubmed publisher
    The objective of this study was to estimate genetic manifestation of Mycobacterium avium ssp. paratuberculosis (MAP) infection in German Holstein cows...
  57. Okuni J, Dovas C, Loukopoulos P, Bouzalas I, Kateete D, Joloba M, et al. Isolation of Mycobacterium avium subspecies paratuberculosis from Ugandan cattle and strain differentiation using optimised DNA typing techniques. BMC Vet Res. 2012;8:99 pubmed publisher
    The occurrence of paratuberculosis in Ugandan cattle has recently been reported but there is no information on the strains of Mycobacterium avium subspecies paratuberculosis (MAP) responsible for the disease...
  58. Chandra S, Faisal S, Chen J, Chen T, McDonough S, Liu S, et al. Immune response and protective efficacy of live attenuated Salmonella vaccine expressing antigens of Mycobacterium avium subsp. paratuberculosis against challenge in mice. Vaccine. 2012;31:242-51 pubmed publisher
    Mycobacterium avium subsp. paratuberculosis (MAP) causes chronic granulomatous enteritis in ruminants that leads to diarrhea and eventually death...
  59. Pithua P, Wells S, Sreevatsan S, Godden S. Lack of evidence for fecal shedding of Mycobacterium avium subsp. paratuberculosis in calves born to fecal culture positive dams. Prev Vet Med. 2010;93:242-5 pubmed publisher
    The objective was to detect presence of calves excreting Mycobacterium avium subsp. paratuberculosis (MAP) in their feces as a consequence of being born to MAP fecal culture positive (vs. negative) dams...
  60. Plain K, Purdie A, Begg D, de Silva K, Whittington R. Toll-like receptor (TLR)6 and TLR1 differentiation in gene expression studies of Johne's disease. Vet Immunol Immunopathol. 2010;137:142-8 pubmed publisher
    ..infection of the gut affecting ruminants and other species caused by Mycobacterium avium subspecies paratuberculosis (MAP)...
  61. Aly S, Mangold B, Whitlock R, Sweeney R, Anderson R, Jiang J, et al. Correlation between Herrold egg yolk medium culture and real-time quantitative polymerase chain reaction results for Mycobacterium avium subspecies paratuberculosis in pooled fecal and environmental samples. J Vet Diagn Invest. 2010;22:677-83 pubmed
    Real-time quantitative polymerase chain reaction (qPCR) testing for Mycobacterium avium subspecies paratuberculosis (MAP) in fecal samples is a rapid alternative to culture on Herrold egg yolk medium (HEYM), the traditional antemortem ..
  62. Mitchell R, Medley G, Collins M, Schukken Y. A meta-analysis of the effect of dose and age at exposure on shedding of Mycobacterium avium subspecies paratuberculosis (MAP) in experimentally infected calves and cows. Epidemiol Infect. 2012;140:231-46 pubmed publisher
    ..b>paratuberculosis (MAP) in cattle...
  63. Stabel J, Waters W, Bannantine J, Lyashchenko K. Mediation of host immune responses after immunization of neonatal calves with a heat-killed Mycobacterium avium subsp. paratuberculosis vaccine. Clin Vaccine Immunol. 2011;18:2079-89 pubmed publisher
    A major drawback of current whole-cell vaccines for Mycobacterium avium subsp. paratuberculosis is the interference with diagnostic tests for bovine tuberculosis (TB) and paratuberculosis...
  64. Subharat S, Shu D, de Lisle G, Buddle B, Wedlock D. Altered patterns of toll-like receptor gene expression in cull cows infected with Mycobacterium avium subsp. paratuberculosis. Vet Immunol Immunopathol. 2012;145:471-8 pubmed publisher
    Johne's disease caused by Mycobacterium avium subsp. paratuberculosis (MAP), is a chronic enteric disease of cattle...
  65. Ghosh P, Hsu C, Alyamani E, Shehata M, Al Dubaib M, Al Naeem A, et al. Genome-wide analysis of the emerging infection with Mycobacterium avium subspecies paratuberculosis in the Arabian camels (Camelus dromedarius). PLoS ONE. 2012;7:e31947 pubmed publisher
    Mycobacterium avium subspecies paratuberculosis (M. ap) is the causative agent of paratuberculosis or Johne's disease (JD) in herbivores with potential involvement in cases of Crohn's disease in humans...
  66. Eisenberg S, Nielen M, Hoeboer J, Rutten V, Heederik D, Koets A. Environmental contamination with Mycobacterium avium subspecies paratuberculosis within and around a dairy barn under experimental conditions. J Dairy Sci. 2012;95:6477-82 pubmed publisher
    To establish environmental contamination in and around a dairy barn, cows shedding Mycobacterium avium ssp. paratuberculosis (MAP) were housed in a freestall barn...
  67. Charavaryamath C, González Cano P, Fries P, Gomis S, Doig K, Scruten E, et al. Host responses to persistent Mycobacterium avium subspecies paratuberculosis infection in surgically isolated bovine ileal segments. Clin Vaccine Immunol. 2013;20:156-65 pubmed publisher
    ..b>paratuberculosis. A model was developed for the controlled delivery of a defined dose of M. avium subsp...
  68. Whittington R, Waldron A, Warne D. Thermal inactivation profiles of Mycobacterium avium subsp. paratuberculosis in lamb skeletal muscle homogenate fluid. Int J Food Microbiol. 2010;137:32-9 pubmed publisher
    Mycobacterium avium subsp. paratuberculosis (MAP) causes Johne's disease in livestock and there is a debate about its role in humans in chronic inflammatory bowel disorders such as Crohn's disease, but the relationship remains unproven...
  69. Foddai A, Elliott C, Grant I. Maximizing capture efficiency and specificity of magnetic separation for Mycobacterium avium subsp. paratuberculosis cells. Appl Environ Microbiol. 2010;76:7550-8 pubmed publisher
    In order to introduce specificity for Mycobacterium avium subsp. paratuberculosis prior to a phage amplification assay, various magnetic-separation approaches, involving either antibodies or peptides, were evaluated in terms of the ..
  70. Santema W, van Kooten P, Hoek A, Leeflang M, Overdijk M, Rutten V, et al. Hsp70 vaccination-induced antibodies recognize B cell epitopes in the cell wall of Mycobacterium avium subspecies paratuberculosis. Vaccine. 2011;29:1364-73 pubmed publisher
    Mycobacterium avium subspecies paratuberculosis (MAP) causes a chronic intestinal infection of ruminants and has been associated with the etiology of human Crohn's disease...
  71. Castellanos E, de Juan L, Dominguez L, Aranaz A. Progress in molecular typing of Mycobacterium avium subspecies paratuberculosis. Res Vet Sci. 2012;92:169-79 pubmed publisher
    Mycobacterium avium subspecies paratuberculosis (M. a. paratuberculosis) is responsible for paratuberculosis or Johne's disease, a chronic inflammation of the gastrointestinal tract in different animal species...
  72. Click R. A 60-day probiotic protocol with Dietzia subsp. C79793-74 prevents development of Johne's disease parameters after in utero and/or neonatal MAP infection. Virulence. 2011;2:337-47 pubmed
    ..subspecies C79793-74, used as a probiotic, could prevent development of parameters indicative of bovine paratuberculosis after potential in utero, birthing and neonatal (colostrum) exposure to Mycobacterium avium subspecies ..
  73. Costanzo G, Pinedo F, Mon M, Viale M, Gil A, Illia M, et al. Accuracy assessment and screening of a dairy herd with paratuberculosis by three different ELISAs. Vet Microbiol. 2012;156:183-8 pubmed publisher
    ..Although the culture of Mycobacterium avium subsp. paratuberculosisis is the gold standard for the diagnosis of paratuberculosis, this bacterium is difficult to grow...
  74. Fisher C, Bhattarai E, Osterstock J, Dowd S, Seabury P, Vikram M, et al. Evolution of the bovine TLR gene family and member associations with Mycobacterium avium subspecies paratuberculosis infection. PLoS ONE. 2011;6:e27744 pubmed publisher
    ..ligands revealed six SNPs potentially eliciting small effects on susceptibility to Mycobacterium avium spp paratuberculosis infection in dairy cattle...
  75. Coussens P, Sipkovsky S, Murphy B, Roussey J, Colvin C. Regulatory T cells in cattle and their potential role in bovine paratuberculosis. Comp Immunol Microbiol Infect Dis. 2012;35:233-9 pubmed publisher
    The intracellular bacterium Mycobacterium avium subspecies paratuberculosis (MAP) causes Johne's disease in wild and domestic ruminants...
  76. Hanifian S, Khani S, Barzegari A, Shayegh J. Quantitative real-time PCR and culture examination of Mycobacterium avium subsp. paratuberculosis at farm level. Vet Microbiol. 2013;162:160-5 pubmed publisher
    Mycobacterium avium subsp. paratuberculosis (MAP) causes Johne's disease in ruminants and may contribute to Crohn's disease in humans...
  77. Carta T, Alvarez J, Perez de la Lastra J, Gortazar C. Wildlife and paratuberculosis: a review. Res Vet Sci. 2013;94:191-7 pubmed publisher
    b>Paratuberculosis (PTB) is an infectious granulomatous enteritis caused by Mycobacterium avium paratuberculosis (MAP) causing significant economic losses in livestock...
  78. Fecteau M, Whitlock R, Buergelt C, Sweeney R. Exposure of young dairy cattle to Mycobacterium avium subsp. paratuberculosis (MAP) through intensive grazing of contaminated pastures in a herd positive for Johne's disease. Can Vet J. 2010;51:198-200 pubmed
    This study investigated the susceptibility of 1- to 2-year-old cattle to Mycobacterium avium subsp. paratuberculosis (MAP) on pasture previously grazed by infected cattle...
  79. Mercier P, Baudry C, Beaudeau F, Seegers H, Malher X. Estimated prevalence of Mycobacterium avium subspecies paratuberculosis infection in herds of dairy goats in France. Vet Rec. 2010;167:412-5 pubmed publisher
    A study of the prevalence of Mycobacterium avium subspecies paratuberculosis (MAP) infection in dairy goats was carried out in France, using a serological ELISA...
  80. Click R, Van Kampen C. Assessment of Dietzia subsp. C79793-74 for treatment of cattle with evidence of paratuberculosis. Virulence. 2010;1:145-55 pubmed publisher
    ..C79793-74, previously shown to inhibit growth of Mycobacterium subsp. paratuberculosis under in vitro culture conditions, has therapeutic value as a probiotic for adult cattle with ..
  81. van Hulzen K, Nielen M, Koets A, de Jong G, van Arendonk J, Heuven H. Effect of herd prevalence on heritability estimates of antibody response to Mycobacterium avium subspecies paratuberculosis. J Dairy Sci. 2011;94:992-7 pubmed publisher
    ..The aim of this study was to estimate genetic parameters for the presence of a Mycobacterium avium ssp. paratuberculosis specific antibody response in milk of Dutch Holstein-Friesian cows using subsets of data based on within-herd ..
  82. Carta T, Martín Hernando M, Boadella M, Fernandez de Mera I, Balseiro A, Sevilla I, et al. No evidence that wild red deer (Cervus elaphus) on the Iberian Peninsula are a reservoir of Mycobacterium avium subspecies paratuberculosis infection. Vet J. 2012;192:544-6 pubmed publisher
    The potential role of red deer (Cervus elaphus) as a reservoir of Mycobacterium avium subspecies paratuberculosis (MAP) infection is largely unknown...
  83. Momotani E. Epidemiological situation and control strategies for paratuberculosis in Japan. Jpn J Vet Res. 2012;60 Suppl:S19-29 pubmed
    b>Paratuberculosis (Ptb), caused by Mycobacterium avium subsp. paratuberculosis (Map), is a chronic and progressive granulomatous enteritis that affects many livestock and wild animals worldwide...
  84. Münster P, Fechner K, Völkel I, von Buchholz A, Czerny C. Distribution of Mycobacterium avium ssp. paratuberculosis in a German zoological garden determined by IS900 semi-nested and quantitative real-time PCR. Vet Microbiol. 2013;163:116-23 pubmed publisher
    Little data concerning the distribution of Mycobacterium avium ssp. paratuberculosis (MAP) in zoological gardens is available...
  85. Scandurra G, de Lisle G, Cavaignac S, Young M, Kawakami R, Collins D. Assessment of live candidate vaccines for paratuberculosis in animal models and macrophages. Infect Immun. 2010;78:1383-9 pubmed publisher
    Mycobacterium avium subsp. paratuberculosis (basonym M. paratuberculosis) is the causative agent of paratuberculosis, a chronic enteritis of ruminants...
  86. Sasikala M, Reddy D, Pratap N, Sharma S, Balkumar P, Sekaran A, et al. Absence of Mycobacterium avium ss paratuberculosis-specific IS900 sequence in intestinal biopsy tissues of Indian patients with Crohn's disease. Indian J Gastroenterol. 2009;28:169-74 pubmed publisher
    The role of Mycobacterium avium ss paratuberculosis (MAP) in the etiopathology of Crohn's disease (CD) remains controversial, because of conflicting reports demonstrating the presence of MAP-specific insertion sequence from intestinal ..
  87. van Hulzen K, Heuven H, Nielen M, Hoeboer J, Santema W, Koets A. Different Mycobacterium avium subsp. paratuberculosis MIRU-VNTR patterns coexist within cattle herds. Vet Microbiol. 2011;148:419-24 pubmed publisher
    A better understanding of the biodiversity of Mycobacterium avium subsp. paratuberculosis (MAP) offers more insight in the epidemiology of paratuberculosis and therefore may contribute to the control of the disease...
  88. Chen J, Faisal S, Chandra S, McDonough S, Moreira M, Scaria J, et al. Immunogenicity and protective efficacy of the Mycobacterium avium subsp. paratuberculosis attenuated mutants against challenge in a mouse model. Vaccine. 2012;30:3015-25 pubmed publisher
    Johne's disease (JD), caused by Mycobacterium avium subsp. paratuberculosis (MAP), results in serious economic losses worldwide especially in cattle, sheep and goats...
  89. Forde T, De Buck J, Elkin B, Kutz S, van der Meer F, Orsel K. Contrasting results of culture-dependent and molecular analyses of Mycobacterium avium subsp. paratuberculosis from wood bison. Appl Environ Microbiol. 2013;79:4448-54 pubmed publisher
    ..Mycobacterium avium subsp. paratuberculosis, a bacterium that causes chronic enteritis in ruminants, is among the pathogens of potential concern for wood ..
  90. Maattanen P, Trost B, Scruten E, Potter A, Kusalik A, Griebel P, et al. Divergent immune responses to Mycobacterium avium subsp. paratuberculosis infection correlate with kinome responses at the site of intestinal infection. Infect Immun. 2013;81:2861-72 pubmed publisher
    Mycobacterium avium subsp. paratuberculosis is the causative agent of Johne's disease (JD) in cattle. M. avium subsp. paratuberculosis infects the gastrointestinal tract of calves, localizing and persisting primarily in the distal ileum...
  91. Stringer L, Wilson P, Heuer C, Mackintosh C. A randomised controlled trial of Silirum vaccine for control of paratuberculosis in farmed red deer. Vet Rec. 2013;173:551 pubmed publisher
    A randomised controlled trial to assess the efficacy of Silirum vaccine in control of paratuberculosis in young farmed deer was carried out in 2008-2009 in six New Zealand herds with a history of clinical disease...
  92. Corn J, Cartwright M, Alexy K, Cornish T, Manning E, Cartoceti A, et al. Surveys for disease agents in introduced elk in Arkansas and Kentucky. J Wildl Dis. 2010;46:186-94 pubmed
    ..Significant findings included isolation of Mycobacterium avium paratuberculosis from one elk in Kentucky and evidence of previous or current infections by Parelaphostrongylus tenuis in ..