treponema pallidum

Summary

Summary: The causative agent of venereal and non-venereal syphilis as well as yaws.

Top Publications

  1. Sun A, Mao Y, Hu Y, Sun Q, Yan J. Sensitive and specific ELISA coated by TpN15-TpN17-TpN47 fusion protein for detection of antibodies to Treponema pallidum. Clin Chem Lab Med. 2009;47:321-6 pubmed publisher
    ..were expressed and then purified antigens were immobilized on the surface of microplate wells for detecting Treponema pallidum-specific antibodies by ELISAs...
  2. STAMM L. Global challenge of antibiotic-resistant Treponema pallidum. Antimicrob Agents Chemother. 2010;54:583-9 pubmed publisher
    ..Macrolide-resistant strains of Treponema pallidum are now prevalent in several developed countries. An understanding of the genetic basis of T...
  3. Martin Ezquerra G, Fernandez Casado A, Barco D, Jucgla A, Juanpere Rodero N, Manresa J, et al. Treponema pallidum distribution patterns in mucocutaneous lesions of primary and secondary syphilis: an immunohistochemical and ultrastructural study. Hum Pathol. 2009;40:624-30 pubmed publisher
    To study the different patterns of Treponema pallidum distribution in primary and secondary syphilis, 34 biopsy specimens of 8 patients with primary and 26 with secondary syphilis were assessed...
  4. Stary G, Klein I, Brüggen M, Kohlhofer S, Brunner P, Spazierer D, et al. Host defense mechanisms in secondary syphilitic lesions: a role for IFN-gamma-/IL-17-producing CD8+ T cells?. Am J Pathol. 2010;177:2421-32 pubmed publisher
    ..By doing so, we detected Treponema pallidum spirochetes with a much greater abundance in late lesions of HIV+ individuals compared with the HIV- cohort...
  5. Grimes M, Sahi S, Godornes B, Tantalo L, Roberts N, Bostick D, et al. Two mutations associated with macrolide resistance in Treponema pallidum: increasing prevalence and correlation with molecular strain type in Seattle, Washington. Sex Transm Dis. 2012;39:954-8 pubmed publisher
    ..treatment failure has been documented and is associated with mutations in the 23S rDNA of corresponding Treponema pallidum strains...
  6. Cruz A, Ramirez L, Zuluaga A, Pillay A, Abreu C, Valencia C, et al. Immune evasion and recognition of the syphilis spirochete in blood and skin of secondary syphilis patients: two immunologically distinct compartments. PLoS Negl Trop Dis. 2012;6:e1717 pubmed publisher
    The clinical syndrome associated with secondary syphilis (SS) reflects the propensity of Treponema pallidum (Tp) to escape immune recognition while simultaneously inducing inflammation.
  7. Wu H, Chang S, Lee N, Huang W, Wu B, Yang C, et al. Evaluation of macrolide resistance and enhanced molecular typing of Treponema pallidum in patients with syphilis in Taiwan: a prospective multicenter study. J Clin Microbiol. 2012;50:2299-304 pubmed publisher
    ..of macrolide resistance mutations and molecular typing using the newly proposed enhanced typing system for Treponema pallidum isolates obtained from HIV-infected patients in the Asia-Pacific region are scarce...
  8. Machius M, Brautigam C, Tomchick D, Ward P, Otwinowski Z, Blevins J, et al. Structural and biochemical basis for polyamine binding to the Tp0655 lipoprotein of Treponema pallidum: putative role for Tp0655 (TpPotD) as a polyamine receptor. J Mol Biol. 2007;373:681-94 pubmed
    Tp0655 of Treponema pallidum, the causative agent of syphilis, is predicted to be a 40 kDa membrane lipoprotein...
  9. Sena A, White B, Sparling P. Novel Treponema pallidum serologic tests: a paradigm shift in syphilis screening for the 21st century. Clin Infect Dis. 2010;51:700-8 pubmed publisher
    The mainstay of diagnosis for Treponema pallidum infections is based on nontreponemal and treponemal serologic tests...

More Information

Publications106 found, 100 shown here

  1. Castro R, Prieto E, Aguas M, Manata M, Botas J, Santo I, et al. Detection of Treponema pallidum sp pallidum DNA in latent syphilis. Int J STD AIDS. 2007;18:842-5 pubmed
    In this study, polymerase chain reaction (PCR) techniques were used to detect Treponema pallidum DNA in samples from patients with latent syphilis. Sixty-nine patients with latent syphilis and 18 with treated syphilis were included...
  2. Pětrošová H, Zobaníková M, Čejková D, Mikalová L, Pospíšilová P, Strouhal M, et al. Whole genome sequence of Treponema pallidum ssp. pallidum, strain Mexico A, suggests recombination between yaws and syphilis strains. PLoS Negl Trop Dis. 2012;6:e1832 pubmed publisher
    b>Treponema pallidum ssp. pallidum (TPA), the causative agent of syphilis, and Treponema pallidum ssp. pertenue (TPE), the causative agent of yaws, are closely related spirochetes causing diseases with distinct clinical manifestations...
  3. Chen C, Chi K, Pillay A, Nachamkin E, Su J, Ballard R. Detection of the A2058G and A2059G 23S rRNA gene point mutations associated with azithromycin resistance in Treponema pallidum by use of a TaqMan real-time multiplex PCR assay. J Clin Microbiol. 2013;51:908-13 pubmed publisher
    ..is associated with a single point mutation (either A2058G or A2059G) in both copies of the 23S rRNA gene in Treponema pallidum strains...
  4. Scott L, Gunson R, Carman W, Winter A. A new multiplex real-time PCR test for HSV1/2 and syphilis: an evaluation of its impact in the laboratory and clinical setting. Sex Transm Infect. 2010;86:537-9 pubmed publisher
    ..A multiplex real-time PCR test detecting HSV1, HSV2 and Treponema pallidum was designed, validated and evaluated for a period of 6 months on patients attending the Sandyford ..
  5. Deka R, Brautigam C, Goldberg M, Schuck P, Tomchick D, Norgard M. Structural, bioinformatic, and in vivo analyses of two Treponema pallidum lipoproteins reveal a unique TRAP transporter. J Mol Biol. 2012;416:678-96 pubmed publisher
    b>Treponema pallidum, the bacterial agent of syphilis, is predicted to encode one tripartite ATP-independent periplasmic transporter (TRAP-T)...
  6. McGill M, Edmondson D, Carroll J, Cook R, Orkiszewski R, Norris S. Characterization and serologic analysis of the Treponema pallidum proteome. Infect Immun. 2010;78:2631-43 pubmed publisher
    b>Treponema pallidum subsp. pallidum is the causative agent of syphilis, a sexually transmitted disease characterized by widespread tissue dissemination and chronic infection. In this study, we analyzed the proteome of T...
  7. Pětrošová H, Pospíšilová P, Strouhal M, Čejková D, Zobaníková M, Mikalová L, et al. Resequencing of Treponema pallidum ssp. pallidum strains Nichols and SS14: correction of sequencing errors resulted in increased separation of syphilis treponeme subclusters. PLoS ONE. 2013;8:e74319 pubmed publisher
    b>Treponema pallidum ssp. pallidum (TPA), the causative agent of syphilis, is a highly clonal bacterium showing minimal genetic variability in the genome sequence of individual strains...
  8. Martin I, Tsang R, Sutherland K, Anderson B, Read R, Roy C, et al. Molecular typing of Treponema pallidum strains in western Canada: predominance of 14d subtypes. Sex Transm Dis. 2010;37:544-8 pubmed publisher
    ..tests for syphilis, identifies macrolide resistance, and uses a molecular typing system to characterize Treponema pallidum clinical strains causing syphilis in Alberta and Northwest Territories, Canada...
  9. Lewis D, Muller E, Steele L, Sternberg M, Radebe F, Lyall M, et al. Prevalence and associations of genital ulcer and urethral pathogens in men presenting with genital ulcer syndrome to primary health care clinics in South Africa. Sex Transm Dis. 2012;39:880-5 pubmed publisher
    ..This study aimed to determine the prevalence of genital ulcer and urethral pathogens, as well as their association with clinical features, in men with genital ulcer disease (GUD) enrolled in a clinical trial...
  10. Meyer C, Jung C, Kohl T, Poenicke A, Poppe A, Alt K. Syphilis 2001--a palaeopathological reappraisal. Homo. 2002;53:39-58 pubmed
    ..With the help of molecular methods which now allow a positive identification of Treponema pallidum pallidum, causative agent of venereal syphilis, in palaeopathological material, it seems possible to ..
  11. Buseri F, Muhibi M, Jeremiah Z. Sero-epidemiology of transfusion-transmissible infectious diseases among blood donors in Osogbo, south-west Nigeria. Blood Transfus. 2009;7:293-9 pubmed publisher
  12. Brautigam C, Deka R, Schuck P, Tomchick D, Norgard M. Structural and thermodynamic characterization of the interaction between two periplasmic Treponema pallidum lipoproteins that are components of a TPR-protein-associated TRAP transporter (TPAT). J Mol Biol. 2012;420:70-86 pubmed publisher
    ..In Treponema pallidum, this protein (TatT) is a water-soluble trimer whose protomers are each perforated by a pore...
  13. Martin I, Tsang R, Sutherland K, Tilley P, Read R, Anderson B, et al. Molecular characterization of syphilis in patients in Canada: azithromycin resistance and detection of Treponema pallidum DNA in whole-blood samples versus ulcerative swabs. J Clin Microbiol. 2009;47:1668-73 pubmed publisher
    Although detection of Treponema pallidum DNA in whole-blood specimens of syphilis patients has been reported, it is uncertain at what stage of the disease such specimens are most suitable for the molecular diagnosis of syphilis...
  14. Snowden J, Konda K, Leon S, Giron J, Escobar G, Coates T, et al. Recent syphilis infection prevalence and risk factors among male low-income populations in coastal Peruvian cities. Sex Transm Dis. 2010;37:75-80 pubmed publisher
    ..These findings demonstrate the need for more effective syphilis control services among those populations, to decrease syphilis-associated morbidity, transmission of syphilis, and the potential transmission of HIV. ..
  15. Van Damme K, Behets F, Ravelomanana N, Godornes C, Khan M, Randrianasolo B, et al. Evaluation of azithromycin resistance in Treponema pallidum specimens from Madagascar. Sex Transm Dis. 2009;36:775-6 pubmed publisher
    b>Treponema pallidum resistance to azithromycin has been documented in the US, Canada, and Ireland...
  16. Mitjà O, Hays R, Ipai A, Wau B, Bassat Q. Osteoperiostitis in early yaws: case series and literature review. Clin Infect Dis. 2011;52:771-4 pubmed publisher
    ..Osteoperiostitis occurred some weeks after the primary infection, and the most common finding was hypertrophic periostitis of long bones. All treated patients had excellent responses to benzyl-penicillin therapy...
  17. Smajs D, Norris S, Weinstock G. Genetic diversity in Treponema pallidum: implications for pathogenesis, evolution and molecular diagnostics of syphilis and yaws. Infect Genet Evol. 2012;12:191-202 pubmed publisher
    Pathogenic uncultivable treponemes, similar to syphilis-causing Treponema pallidum subspecies pallidum, include T. pallidum ssp. pertenue, T. pallidum ssp. endemicum and Treponema carateum, which cause yaws, bejel and pinta, respectively...
  18. Giacani L, Lukehart S, Centurion Lara A. Length of guanosine homopolymeric repeats modulates promoter activity of subfamily II tpr genes of Treponema pallidum ssp. pallidum. FEMS Immunol Med Microbiol. 2007;51:289-301 pubmed
    In Treponema pallidum, homopolymeric guanosine repeats of varying length are present upstream of both Subfamily I (tprC, D, F and I) and II (tprE, G and J) tpr genes, a group of potential virulence factors, immediately upstream of the +1 ..
  19. de Melo F, de Mello J, Fraga A, Nunes K, Eggers S. Syphilis at the crossroad of phylogenetics and paleopathology. PLoS Negl Trop Dis. 2010;4:e575 pubmed publisher
    ..Then, we selected the oldest ones to calibrate the time of the most recent common ancestor of Treponema pallidum subsp. pallidum, T. pallidum subsp. endemicum and T. pallidum subsp...
  20. Asiedu K, Amouzou B, Dhariwal A, Karam M, Lobo D, Patnaik S, et al. Yaws eradication: past efforts and future perspectives. Bull World Health Organ. 2008;86:499-499A pubmed
  21. Tipple C, McClure M, Taylor G. High prevalence of macrolide resistant Treponema pallidum strains in a London centre. Sex Transm Infect. 2011;87:486-8 pubmed publisher
    Macrolide resistant Treponema pallidum strains, caused by mutations in the 23S ribosomal RNA (23S rRNA) gene, are widespread and increasingly prevalent...
  22. Dai T, Li K, Lu H, Gu X, Wang Q, Zhou P. Molecular typing of Treponema pallidum: a 5-year surveillance in Shanghai, China. J Clin Microbiol. 2012;50:3674-7 pubmed publisher
    Previously, a small study showed that 14f was the predominant subtype of Treponema pallidum in Shanghai, China. The result was quite different from the genotype distribution in other areas of China...
  23. Giacani L, Godornes C, Puray Chavez M, Guerra Giraldez C, Tompa M, Lukehart S, et al. TP0262 is a modulator of promoter activity of tpr Subfamily II genes of Treponema pallidum ssp. pallidum. Mol Microbiol. 2009;72:1087-99 pubmed publisher
    Transcriptional regulation in Treponema pallidum ssp. pallidum is poorly understood, primarily because this organism cannot be cultivated in vitro or genetically manipulated...
  24. Becker M, Stephen J, Moses S, Washington R, Maclean I, Cheang M, et al. Etiology and determinants of sexually transmitted infections in Karnataka state, south India. Sex Transm Dis. 2010;37:159-64 pubmed publisher
    ..Participants with genital ulcers were tested for Treponema pallidum (TP), Haemophilus ducreyi (HD), and HSV-2...
  25. Prabhakar P, Narayanan P, Deshpande G, Das A, Neilsen G, Mehendale S, et al. Genital ulcer disease in India: etiologies and performance of current syndrome guidelines. Sex Transm Dis. 2012;39:906-10 pubmed publisher
  26. Cruz A, Moore M, La Vake C, Eggers C, Salazar J, Radolf J. Phagocytosis of Borrelia burgdorferi, the Lyme disease spirochete, potentiates innate immune activation and induces apoptosis in human monocytes. Infect Immun. 2008;76:56-70 pubmed
    ..Surprisingly, opsonophagocytosis of Treponema pallidum did not elicit a discernible cell death response. Our combined results demonstrate that B...
  27. Müller E, Paz Bailey G, Lewis D. Macrolide resistance testing and molecular subtyping of Treponema pallidum strains from southern Africa. Sex Transm Infect. 2012;88:470-4 pubmed
    ..A2058G and A2059G mutations that confer macrolide resistance are present among southern African strains of Treponema pallidum and to determine their subtype distribution...
  28. Strouhal M, Smajs D, Matejková P, Sodergren E, Amin A, Howell J, et al. Genome differences between Treponema pallidum subsp. pallidum strain Nichols and T. paraluiscuniculi strain Cuniculi A. Infect Immun. 2007;75:5859-66 pubmed
    ..genome of Treponema paraluiscuniculi strain Cuniculi A was compared to the genome of the syphilis spirochete Treponema pallidum subsp...
  29. Lukehart S. Scientific monogamy: thirty years dancing with the same bug: 2007 Thomas Parran Award Lecture. Sex Transm Dis. 2008;35:2-7 pubmed
  30. Marra C, Sahi S, Tantalo L, Godornes C, Reid T, Behets F, et al. Enhanced molecular typing of treponema pallidum: geographical distribution of strain types and association with neurosyphilis. J Infect Dis. 2010;202:1380-8 pubmed publisher
    Strain typing is a tool for determining the diversity and epidemiology of infections. Treponema pallidum DNA was isolated from 158 patients with syphilis from the United States, China, Ireland, and Madagascar and from 15 T...
  31. Pillay A, Chen C, Reynolds M, Mombouli J, Castro A, Louvouezo D, et al. Laboratory-confirmed case of yaws in a 10-year-old boy from the Republic of the Congo. J Clin Microbiol. 2011;49:4013-5 pubmed publisher
    ..This is the first report describing the use of DNA sequencing to identify Treponema pallidum subsp. pertenue-specific sequences in a patient with active yaws.
  32. Makasa M, Buve A, Sandøy I. Etiologic pattern of genital ulcers in Lusaka, Zambia: has chancroid been eliminated?. Sex Transm Dis. 2012;39:787-91 pubmed
    ..Monitoring local etiologies provides information that may aid policy for sexually transmitted infection treatment. We investigated the etiology of genital ulcer disease among outpatients in Lusaka, Zambia...
  33. Gayet Ageron A, Ninet B, Toutous Trellu L, Lautenschlager S, Furrer H, Piguet V, et al. Assessment of a real-time PCR test to diagnose syphilis from diverse biological samples. Sex Transm Infect. 2009;85:264-9 pubmed publisher
    To investigate the contribution of a real-time PCR assay for the detection of Treponema pallidum in various biological specimens with the secondary objective of comparing its value according to HIV status...
  34. Sun R, Lai D, Ren R, Lian S, Zhang H. Treponema pallidum-specific antibody expression for the diagnosis of different stages of syphilis. Chin Med J (Engl). 2013;126:206-10 pubmed
    Tp15, Tp17, Tp45, and Tp47 are outer-membrane proteins found in Treponema pallidum, the etiologic agent of syphilis. These proteins are potent antigens and are potential markers for the serological detection of syphilis...
  35. Lin L, Tong M, Fu Z, Dan B, Zheng W, Zhang C, et al. Evaluation of a colloidal gold immunochromatography assay in the detection of Treponema pallidum specific IgM antibody in syphilis serofast reaction patients: a serologic marker for the relapse and infection of syphilis. Diagn Microbiol Infect Dis. 2011;70:10-6 pubmed publisher
    ..A new testing method to detect Treponema pallidum IgM (TP-IgM), named colloidal gold immunochromatography assay (GICA), is presented in place of fluorescent ..
  36. Martin I, Gu W, Yang Y, Tsang R. Macrolide resistance and molecular types of Treponema pallidum causing primary syphilis in Shanghai, China. Clin Infect Dis. 2009;49:515-21 pubmed publisher
    ..This study focuses on implementing polymerase chain reaction (PCR) diagnostic tests for syphilis and for detection of molecular subtypes and macrolide resistance among strains causing primary syphilis in the city of Shanghai, China...
  37. Owusu Edusei K, Peterman T, Ballard R. Serologic testing for syphilis in the United States: a cost-effectiveness analysis of two screening algorithms. Sex Transm Dis. 2011;38:1-7 pubmed publisher
    ..We compared the economic and health outcomes of this new algorithm with the standard algorithm from the perspective of the United States health system...
  38. Babolin C, Amedei A, Ozolins D, Zilevica A, D Elios M, de Bernard M. TpF1 from Treponema pallidum activates inflammasome and promotes the development of regulatory T cells. J Immunol. 2011;187:1377-84 pubmed publisher
    Human syphilis is a multistage disease, with diverse and wide-ranging manifestations caused by Treponema pallidum. Despite the fact that a cell-mediated immune response takes part in the course of syphilis, T...
  39. Zhao F, Wu Y, Zhang X, Yu J, Gu W, Liu S, et al. Enhanced immune response and protective efficacy of a Treponema pallidum Tp92 DNA vaccine vectored by chitosan nanoparticles and adjuvanted with IL-2. Hum Vaccin. 2011;7:1083-9 pubmed publisher
    ..efficacy of using an interleukin-2 (IL-2) expression plasmid as a genetic adjuvant and chitosan (CS) nanoparticles as vectors to enhance a Tp92 DNA vaccine candidate were investigated in a Treponema pallidum (Tp) rabbit challenge model.
  40. Peng R, Wang A, Li J, Tucker J, Yin Y, Chen X. Molecular typing of Treponema pallidum: a systematic review and meta-analysis. PLoS Negl Trop Dis. 2011;5:e1273 pubmed publisher
    ..This study aimed to review original research on molecular typing of Treponema pallidum (T...
  41. Katz K, Klausner J. Azithromycin resistance in Treponema pallidum. Curr Opin Infect Dis. 2008;21:83-91 pubmed publisher
    ..We discuss azithromycin-related treatment failures and resistance in Treponema pallidum, and propose ways to meet the resulting clinical and public health challenges.
  42. Martin I, Lau A, Sawatzky P, Tsang R, Cuff W, Lee C, et al. Serological diagnosis of syphilis: enzyme-linked immunosorbent assay to measure antibodies to individual recombinant Treponema pallidum antigens. J Immunoassay Immunochem. 2008;29:143-51 pubmed publisher
    ..Further evaluations with sera from different stages of syphilis can help to define the applications of this ELISA test for each of the four antigens studied...
  43. Matejková P, Flasarová M, Zákoucká H, Borek M, Kremenová S, Arenberger P, et al. Macrolide treatment failure in a case of secondary syphilis: a novel A2059G mutation in the 23S rRNA gene of Treponema pallidum subsp. pallidum. J Med Microbiol. 2009;58:832-6 pubmed publisher
    ..The occurrence of this novel 23S rDNA mutation was examined among 7 rabbit-propagated syphilitic strains of Treponema pallidum and among 22 syphilis patient isolates from the Czech Republic...
  44. Izard J, Renken C, Hsieh C, Desrosiers D, Dunham Ems S, La Vake C, et al. Cryo-electron tomography elucidates the molecular architecture of Treponema pallidum, the syphilis spirochete. J Bacteriol. 2009;191:7566-80 pubmed publisher
    Cryo-electron tomography (CET) was used to examine the native cellular organization of Treponema pallidum, the syphilis spirochete. T...
  45. Giacani L, Molini B, Kim E, Godornes B, Leader B, Tantalo L, et al. Antigenic variation in Treponema pallidum: TprK sequence diversity accumulates in response to immune pressure during experimental syphilis. J Immunol. 2010;184:3822-9 pubmed publisher
    ..In Treponema pallidum (T...
  46. Liu J, Howell J, Bradley S, Zheng Y, Zhou Z, Norris S. Cellular architecture of Treponema pallidum: novel flagellum, periplasmic cone, and cell envelope as revealed by cryo electron tomography. J Mol Biol. 2010;403:546-61 pubmed publisher
    High-resolution cryo electron tomography (cryo-ET) was utilized to visualize Treponema pallidum, the causative agent of syphilis, at the molecular level...
  47. Houston S, Hof R, Francescutti T, Hawkes A, Boulanger M, Cameron C. Bifunctional role of the Treponema pallidum extracellular matrix binding adhesin Tp0751. Infect Immun. 2011;79:1386-98 pubmed publisher
    b>Treponema pallidum, the causative agent of syphilis, is a highly invasive pathogenic spirochete capable of attaching to host cells, invading the tissue barrier, and undergoing rapid widespread dissemination via the circulatory system...
  48. Heymans R, van der Helm J, de Vries H, Fennema H, Coutinho R, Bruisten S. Clinical value of Treponema pallidum real-time PCR for diagnosis of syphilis. J Clin Microbiol. 2010;48:497-502 pubmed publisher
    ..In the present study, therefore, we examined the additional clinical value of a Treponema pallidum real-time TaqMan PCR for the detection of primary and secondary syphilis. The additional value of the T...
  49. Rotty J, Anderson D, Garcia M, Diaz J, van de Waarsenburg S, Howard T, et al. Preliminary assessment of Treponema pallidum-specific IgM antibody detection and a new rapid point-of-care assay for the diagnosis of syphilis in human immunodeficiency virus-1-infected patients. Int J STD AIDS. 2010;21:758-64 pubmed publisher
    The aims of the study were to assess whether Treponema pallidum-specific IgM may provide a useful marker of infectious syphilis in human immunodeficiency virus (HIV)-infected patients, and to compare the performance of a prototype IgM-..
  50. Pando M, Reynaga E, Coloccini R, Rodriguez Fermepin M, Kochel T, Montano S, et al. [Prevalence of HIV infection and Treponema pallidum in Argentine female sex workers]. Rev Panam Salud Publica. 2011;30:303-8 pubmed
    Estimate the prevalence of human immunodeficiency virus (HIV) infection and Treponema pallidum in Argentine female sex workers (FSW), and describe the sociodemographic characteristics of this population group associated with HIV ..
  51. Azzato F, Ryan N, Fyfe J, Leslie D. Molecular subtyping of Treponema pallidum during a local syphilis epidemic in men who have sex with men in Melbourne, Australia. J Clin Microbiol. 2012;50:1895-9 pubmed publisher
    b>Treponema pallidum is the causative agent of syphilis, a sexually transmitted infection of significant public health importance...
  52. Flasarová M, Pospíšilová P, Mikalová L, Vališová Z, Dastychová E, Strnadel R, et al. Sequencing-based molecular typing of treponema pallidum strains in the Czech Republic: all identified genotypes are related to the sequence of the SS14 strain. Acta Derm Venereol. 2012;92:669-74 pubmed publisher
    ..The variants of arp and tpr genes appear to combine independently with sequence variants of TP0136, TP0548 and 23S rRNA genes...
  53. Giacani L, Chattopadhyay S, Centurion Lara A, Jeffrey B, Le H, Molini B, et al. Footprint of positive selection in Treponema pallidum subsp. pallidum genome sequences suggests adaptive microevolution of the syphilis pathogen. PLoS Negl Trop Dis. 2012;6:e1698 pubmed publisher
    In the rabbit model of syphilis, infection phenotypes associated with the Nichols and Chicago strains of Treponema pallidum (T. pallidum), though similar, are not identical...
  54. Brautigam C, Deka R, Ouyang Z, Machius M, Knutsen G, Tomchick D, et al. Biophysical and bioinformatic analyses implicate the Treponema pallidum Tp34 lipoprotein (Tp0971) in transition metal homeostasis. J Bacteriol. 2012;194:6771-81 pubmed publisher
    ..The genome of the etiologic agent of syphilis, Treponema pallidum, is compact and devoid of many metabolic enzyme genes...
  55. Chen X, Yin Y, Wei W, Wang H, Peng R, Zheng H, et al. High prevalence of azithromycin resistance to Treponema pallidum in geographically different areas in China. Clin Microbiol Infect. 2013;19:975-9 pubmed publisher
    ..65 (95% CI, 5.77-66.93). It can be concluded that prevalence of azithromycin resistance is substantial in China and consequently that the macrolides should not be used as a treatment option for early or incubating syphilis in China...
  56. Herremans M, Notermans D, Mommers M, Kortbeek L. Comparison of a Treponema pallidum IgM immunoblot with a 19S fluorescent treponemal antibody absorption test for the diagnosis of congenital syphilis. Diagn Microbiol Infect Dis. 2007;59:61-6 pubmed
    We compared an in-house Treponema pallidum IgM immunoblot (IB) with a 19S fluorescent treponemal antibody absorption (IgM) test during routine use for the diagnosis of congenital syphilis (CS) in a national reference laboratory in a ..
  57. Harper K, Ocampo P, Steiner B, George R, Silverman M, Bolotin S, et al. On the origin of the treponematoses: a phylogenetic approach. PLoS Negl Trop Dis. 2008;2:e148 pubmed publisher
    ..Since the first recorded epidemic of syphilis in 1495, controversy has surrounded the origins of the bacterium Treponema pallidum subsp...
  58. Maple P, Ratcliffe D, Smit E. Characterization of Treponema pallidum particle agglutination assay-negative sera following screening by treponemal total antibody enzyme immunoassays. Clin Vaccine Immunol. 2010;17:1718-22 pubmed publisher
    Following a laboratory audit, a significant number of Treponema pallidum particle agglutination assay (TPPA)-negative sera were identified when TPPA was used as a confirmatory assay of syphilis enzyme immunoassay (EIA) screening-reactive ..
  59. Anand A, Luthra A, Dunham Ems S, Caimano M, Karanian C, Ledoyt M, et al. TprC/D (Tp0117/131), a trimeric, pore-forming rare outer membrane protein of Treponema pallidum, has a bipartite domain structure. J Bacteriol. 2012;194:2321-33 pubmed publisher
    Identification of Treponema pallidum rare outer membrane proteins (OMPs) has been a longstanding objective of syphilis researchers...
  60. Yin Y, Chen X, Wei W, Gong K, Cao W, Yong G, et al. A dual point-of-care test shows good performance in simultaneously detecting nontreponemal and treponemal antibodies in patients with syphilis: a multisite evaluation study in China. Clin Infect Dis. 2013;56:659-65 pubmed publisher
    ..This study aimed to conduct a multisite performance evaluation of a dual POC syphilis test in China...
  61. Clark J, Konda K, Munayco C, Pun M, Lescano A, Leon S, et al. Prevalence of HIV, herpes simplex virus-2, and syphilis in male sex partners of pregnant women in Peru. BMC Public Health. 2008;8:65 pubmed publisher
    ..We sought to determine the prevalence of HIV, herpes simplex virus type 2 (HSV-2), and syphilis infection and associated risk behaviors among male sex partners of pregnant women in Peru...
  62. Grange P, Gressier L, Dion P, Farhi D, Benhaddou N, Gerhardt P, et al. Evaluation of a PCR test for detection of treponema pallidum in swabs and blood. J Clin Microbiol. 2012;50:546-52 pubmed publisher
    ..is based on clinical observation, serological analysis, and dark-field microscopy (DFM) detection of Treponema pallidum subsp. pallidum, the etiological agent of syphilis, in skin ulcers...
  63. Čejková D, Zobaníková M, Chen L, Pospíšilová P, Strouhal M, Qin X, et al. Whole genome sequences of three Treponema pallidum ssp. pertenue strains: yaws and syphilis treponemes differ in less than 0.2% of the genome sequence. PLoS Negl Trop Dis. 2012;6:e1471 pubmed publisher
    The yaws treponemes, Treponema pallidum ssp. pertenue (TPE) strains, are closely related to syphilis causing strains of Treponema pallidum ssp. pallidum (TPA)...
  64. . Prevalence of the 23S rRNA A2058G point mutation and molecular subtypes in Treponema pallidum in the United States, 2007 to 2009. Sex Transm Dis. 2012;39:794-8 pubmed
    The 23S rRNA A2058G point mutation in Treponema pallidum is associated with macrolide antibiotic treatment failure. Its prevalence and potential association with a molecular subtype within the United States are unknown.
  65. Čejková D, Zobaníková M, Pospíšilová P, Strouhal M, Mikalová L, Weinstock G, et al. Structure of rrn operons in pathogenic non-cultivable treponemes: sequence but not genomic position of intergenic spacers correlates with classification of Treponema pallidum and Treponema paraluiscuniculi strains. J Med Microbiol. 2013;62:196-207 pubmed publisher
    ..It is suggested that the random distribution of tRNA genes is caused by reciprocal translocation between repetitive sequences mediated by a recBCD-like system...
  66. Young H, Pryde J, Duncan L, Dave J. The Architect Syphilis assay for antibodies to Treponema pallidum: an automated screening assay with high sensitivity in primary syphilis. Sex Transm Infect. 2009;85:19-23 pubmed publisher
    ..To determine the sensitivity and specificity of the Architect Syphilis Chemiluminescence Assay (CLIA): a new highly automated screening test for syphilis...
  67. Heymans R, Kolader M, van der Helm J, Coutinho R, Bruisten S. TprK gene regions are not suitable for epidemiological syphilis typing. Eur J Clin Microbiol Infect Dis. 2009;28:875-8 pubmed publisher
    ..syphilis incidence in Western countries, we used molecular typing and epidemiological data to elucidate Treponema pallidum transmission networks...
  68. Castro R, Prieto E, Aguas M, Manata M, Botas J, Pereira F. Molecular subtyping of Treponema pallidum subsp. pallidum in Lisbon, Portugal. J Clin Microbiol. 2009;47:2510-2 pubmed publisher
    The objectives of this study were to evaluate the reproducibility of a molecular method for the subtyping of Treponema pallidum subsp. pallidum and to discriminate strains of this microorganism from strains from patients with syphilis...
  69. Knauf S, Batamuzi E, Mlengeya T, Kilewo M, Lejora I, Nordhoff M, et al. Treponema infection associated with genital ulceration in wild baboons. Vet Pathol. 2012;49:292-303 pubmed publisher
    The authors describe genital alterations and detailed histologic findings in baboons naturally infected with Treponema pallidum. The disease causes moderate to severe genital ulcerations in a population of olive baboons (Papio hamadryas ..
  70. Desrosiers D, Anand A, Luthra A, Dunham Ems S, Ledoyt M, Cummings M, et al. TP0326, a Treponema pallidum ?-barrel assembly machinery A (BamA) orthologue and rare outer membrane protein. Mol Microbiol. 2011;80:1496-515 pubmed publisher
    Definitive identification of Treponema pallidum rare outer membrane proteins (OMPs) has long eluded researchers. TP0326, the sole protein in T...
  71. Liu Z, Zhang Y, Qiu K, Du S. Osteomyelitis as the only manifestation of late latent syphilis: case report and literature review. Int J STD AIDS. 2011;22:353-5 pubmed publisher
    ..We report a case of a 62-year-old man who presented with one-month acute pain in the left leg. Treponema pallidum particle agglutination test was positive, and radiography showed a pathological fracture of the left ..
  72. Long F, Zhang J, Shang G, Shang S, Gong K, Wang Q. Seroreactivity and immunogenicity of Tp0965, a hypothetical membrane protein of Treponema pallidum. Chin Med J (Engl). 2012;125:1920-4 pubmed
    b>Treponema pallidum (T. pallidum) subsp. pallidum is the causative agent of syphilis. Analysis of recombinant antigens of T...
  73. Giacani L, Jeffrey B, Molini B, Le H, Lukehart S, Centurion Lara A, et al. Complete genome sequence and annotation of the Treponema pallidum subsp. pallidum Chicago strain. J Bacteriol. 2010;192:2645-6 pubmed publisher
    In syphilis research, the Nichols strain of Treponema pallidum, isolated in 1912, has been the most widely studied. Recently, important differences among T...
  74. Cruz A, Pillay A, Zuluaga A, Ramirez L, Duque J, Aristizabal G, et al. Secondary syphilis in cali, Colombia: new concepts in disease pathogenesis. PLoS Negl Trop Dis. 2010;4:e690 pubmed publisher
    Venereal syphilis is a multi-stage, sexually transmitted disease caused by the spirochetal bacterium Treponema pallidum (Tp)...
  75. Zhou P, Li K, Lu H, Qian Y, Gu X, Gong W, et al. Azithromycin treatment failure among primary and secondary syphilis patients in Shanghai. Sex Transm Dis. 2010;37:726-9 pubmed publisher
    ..Azithromycin has been used to treat primary and secondary syphilis and as prophylaxis for sexual partners. We evaluated syphilis treatment failure in patients who received azithromycin therapy...
  76. Cox D, Luthra A, Dunham Ems S, Desrosiers D, Salazar J, Caimano M, et al. Surface immunolabeling and consensus computational framework to identify candidate rare outer membrane proteins of Treponema pallidum. Infect Immun. 2010;78:5178-94 pubmed publisher
    b>Treponema pallidum reacts poorly with the antibodies present in rabbit and human syphilitic sera, a property attributed to the paucity of proteins in its outer membrane...
  77. Mikalová L, Strouhal M, Čejková D, Zobaníková M, Pospíšilová P, Norris S, et al. Genome analysis of Treponema pallidum subsp. pallidum and subsp. pertenue strains: most of the genetic differences are localized in six regions. PLoS ONE. 2010;5:e15713 pubmed publisher
    ..p. pallidum and T. p. pertenue strains. These regions of sequence divergence could be used for the molecular detection and discrimination of syphilis and yaws strains...
  78. Ramos J, Toro C, Reyes F, Amor A, Gutierrez F. Seroprevalence of HIV-1, HBV, HTLV-1 and Treponema pallidum among pregnant women in a rural hospital in Southern Ethiopia. J Clin Virol. 2011;51:83-5 pubmed publisher
    ..virus type 1 (HIV-1), hepatitis B virus (HBV), human T-cell lymphotropic virus type 1 (HTLV-1) and Treponema pallidum represent major public health problems in sub-Saharan countries...
  79. Luthra A, Zhu G, Desrosiers D, Eggers C, Mulay V, Anand A, et al. The transition from closed to open conformation of Treponema pallidum outer membrane-associated lipoprotein TP0453 involves membrane sensing and integration by two amphipathic helices. J Biol Chem. 2011;286:41656-68 pubmed publisher
    The molecular architecture and composition of the outer membrane (OM) of Treponema pallidum (Tp), the noncultivable agent of venereal syphilis, differ considerably from those of typical Gram-negative bacteria...
  80. Muldoon E, Walsh A, Crowley B, Mulcahy F. Treponema pallidum azithromycin resistance in Dublin, Ireland. Sex Transm Dis. 2012;39:784-6 pubmed
    ..Of the 104 samples, 36 (34.6%) were positive for Treponema pallidum DNA by polymerase chain reaction. Thirty samples were analyzed for A2058G mutation, 29 samples sequenced...
  81. Mitjà O, Asiedu K, Mabey D. Yaws. Lancet. 2013;381:763-73 pubmed publisher
    Yaws is an infectious disease caused by Treponema pallidum pertenue-a bacterium that closely resembles the causative agent of syphilis-and is spread by skin-to-skin contact in humid tropical regions...
  82. Brinkman M, McGill M, Pettersson J, Rogers A, Matejková P, Smajs D, et al. A novel Treponema pallidum antigen, TP0136, is an outer membrane protein that binds human fibronectin. Infect Immun. 2008;76:1848-57 pubmed publisher
    The antigenicity, structural location, and function of the predicted lipoprotein TP0136 of Treponema pallidum subsp...
  83. Titz B, Rajagopala S, Goll J, Hauser R, McKevitt M, Palzkill T, et al. The binary protein interactome of Treponema pallidum--the syphilis spirochete. PLoS ONE. 2008;3:e2292 pubmed publisher
    ..Here we present the protein interaction network for the syphilis spirochete Treponema pallidum which encodes 1,039 proteins, 726 (or 70%) of which interact via 3,649 interactions as revealed by ..
  84. Florindo C, Reigado V, Gomes J, Azevedo J, Santo I, Borrego M. Molecular typing of treponema pallidum clinical strains from Lisbon, Portugal. J Clin Microbiol. 2008;46:3802-3 pubmed publisher
    A molecular system was used to subtype Portuguese Treponema pallidum clinical strains isolated from both skin lesions and blood. The study with this system constitutes the first typing study in a European country. Three T...
  85. Suntoke T, Hardick A, Tobian A, Mpoza B, Laeyendecker O, Serwadda D, et al. Evaluation of multiplex real-time PCR for detection of Haemophilus ducreyi, Treponema pallidum, herpes simplex virus type 1 and 2 in the diagnosis of genital ulcer disease in the Rakai District, Uganda. Sex Transm Infect. 2009;85:97-101 pubmed publisher
    ..predominant sexually transmitted aetiological agents of genital ulcer disease (GUD) (Haemophilus ducreyi, Treponema pallidum and herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2)) and to assess the use of real-time PCR ..
  86. Cole M, Chisholm S, Palmer H, Wallace L, Ison C. Molecular epidemiology of syphilis in Scotland. Sex Transm Infect. 2009;85:447-51 pubmed publisher
    ..To examine the molecular epidemiology of syphilis in Scotland...
  87. Tang J, Zhou L, Gao W, Cao X, Wang Y. Visual DNA microarrays for simultaneous detection of human immunodeficiency virus type-1 and Treponema pallidum coupled with multiplex asymmetric polymerase chain reaction. Diagn Microbiol Infect Dis. 2009;65:372-8 pubmed publisher
    ..for simultaneous, sensitive, and specific detection of human immunodeficiency virus type-1 (HIV-1) and Treponema pallidum. The 5'-end amino-modified oligonucleotides were immobilized on glass surface, which were used as the ..
  88. Katz K, Pillay A, Ahrens K, Kohn R, Hermanstyne K, Bernstein K, et al. Molecular epidemiology of syphilis--San Francisco, 2004-2007. Sex Transm Dis. 2010;37:660-3 pubmed publisher
    We describe the molecular epidemiology of syphilis in San Francisco (SF) using Treponema pallidum specimens obtained from patients examined at the SF municipal sexually transmitted diseases clinic during 2004-2007...
  89. Peng R, Yin Y, Wei W, Wang H, Zhu B, Liu Q, et al. Molecular typing of Treponema pallidum causing early syphilis in China: a cross-sectional study. Sex Transm Dis. 2012;39:42-5 pubmed publisher
    There have been limited data on molecular epidemiology of syphilis in China. This study aimed to analyze strain type distribution of Treponema pallidum causing early syphilis across geographic areas in China using an enhanced method.
  90. Cameron C, Kuroiwa J, Yamada M, Francescutti T, Chi B, Kuramitsu H. Heterologous expression of the Treponema pallidum laminin-binding adhesin Tp0751 in the culturable spirochete Treponema phagedenis. J Bacteriol. 2008;190:2565-71 pubmed publisher
    b>Treponema pallidum subsp. pallidum, the causative agent of syphilis, is an unculturable, genetically intractable bacterium. Here we report the use of the shuttle vector pKMR4PEMCS for the expression of a previously identified T...
  91. Matejková P, Strouhal M, Smajs D, Norris S, Palzkill T, Petrosino J, et al. Complete genome sequence of Treponema pallidum ssp. pallidum strain SS14 determined with oligonucleotide arrays. BMC Microbiol. 2008;8:76 pubmed publisher
    Syphilis spirochete Treponema pallidum ssp. pallidum remains the enigmatic pathogen, since no virulence factors have been identified and the pathogenesis of the disease is poorly understood...
  92. Parsonage D, Desrosiers D, Hazlett K, Sun Y, NELSON K, Cox D, et al. Broad specificity AhpC-like peroxiredoxin and its thioredoxin reductant in the sparse antioxidant defense system of Treponema pallidum. Proc Natl Acad Sci U S A. 2010;107:6240-5 pubmed publisher
    Little is known about the mechanisms by which Treponema pallidum (Tp), the causative agent of syphilis, copes with oxidative stress as it establishes persistent infection within its obligate human host...