treponema denticola

Summary

Summary: A species of bacteria in the family SPIROCHAETACEAE, frequently isolated from periodontal pockets (PERIODONTAL POCKET).

Top Publications

  1. Demmer R, Desvarieux M. Periodontal infections and cardiovascular disease: the heart of the matter. J Am Dent Assoc. 2006;137 Suppl:14S-20S; quiz 38S pubmed
    ..Periodontal infections are a leading culprit, with studies reporting associations between periodontal disease and CVD. The results, however, have varied, and it often is unclear what conclusions can be drawn from these data...
  2. Derdilopoulou F, Nonhoff J, Neumann K, Kielbassa A. Microbiological findings after periodontal therapy using curettes, Er:YAG laser, sonic, and ultrasonic scalers. J Clin Periodontol. 2007;34:588-98 pubmed
    ..To evaluate and compare the microbiological effects of hand instruments, Er:YAG-laser, sonic, and ultrasonic scalers in patients with chronic periodontitis. Patient perception of each treatment was documented...
  3. Mineoka T, Awano S, Rikimaru T, Kurata H, Yoshida A, Ansai T, et al. Site-specific development of periodontal disease is associated with increased levels of Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia in subgingival plaque. J Periodontol. 2008;79:670-6 pubmed
    Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia (previously T. forsythensis), which are regarded as the principal periodontopathogenic bacteria, exist as a consortium in subgingival biofilms...
  4. Yamazaki T, Miyamoto M, Yamada S, Okuda K, Ishihara K. Surface protease of Treponema denticola hydrolyzes C3 and influences function of polymorphonuclear leukocytes. Microbes Infect. 2006;8:1758-63 pubmed
    b>Treponema denticola is a dominant microorganism in human periodontal lesions. One of the major virulence factors of this microorganism is its chymotrypsin-like surface protease, dentilisin...
  5. Brissette C, Pham T, Coats S, Darveau R, Lukehart S. Treponema denticola does not induce production of common innate immune mediators from primary gingival epithelial cells. Oral Microbiol Immunol. 2008;23:474-81 pubmed publisher
    ..In periodontitis, this gradient is disrupted, impairing neutrophil chemotaxis to diseased sites. Treponema denticola is prominently associated with periodontal disease, yet little is known about its ability to modulate the ..
  6. Gonzalez C, Stonestrom A, Lorca G, Saier M. Biochemical characterization of phosphoryl transfer involving HPr of the phosphoenolpyruvate-dependent phosphotransferase system in Treponema denticola, an organism that lacks PTS permeases. Biochemistry. 2005;44:598-608 pubmed
    Treponema pallidum and Treponema denticola encode within their genomes homologues of energy coupling and regulatory proteins of the phosphoenolpyruvate:sugar phosphotransferase system (PTS) but no recognizable homologues of PTS permeases...
  7. Tanabe S, Bodet C, Grenier D. Treponema denticola lipooligosaccharide activates gingival fibroblasts and upregulates inflammatory mediator production. J Cell Physiol. 2008;216:727-31 pubmed publisher
    ..The spirochete Treponema denticola is a major etiological agent of periodontitis and can invade oral tissues...
  8. Sarkar J, Frederick J, Marconi R. The Hpk2-Rrp2 two-component regulatory system of Treponema denticola: a potential regulator of environmental and adaptive responses. Mol Oral Microbiol. 2010;25:241-51 pubmed publisher
    b>Treponema denticola levels in the gingival crevice become elevated as periodontal disease develops. Oral treponemes may account for as much as 40% of the total bacterial population in the periodontal pocket...
  9. Shin J, Choi Y. The fate of Treponema denticola within human gingival epithelial cells. Mol Oral Microbiol. 2012;27:471-82 pubmed publisher
    b>Treponema denticola is one of the major pathogens associated with chronic periodontitis. Bacterial invasion into gingival tissues is a critical process in the pathogenesis of periodontal disease. We recently reported that T...

More Information

Publications94

  1. Gomes B, Jacinto R, Pinheiro E, Sousa E, Zaia A, Ferraz C, et al. Molecular analysis of Filifactor alocis, Tannerella forsythia, and treponema denticola associated with primary endodontic infections and failed endodontic treatment. J Endod. 2006;32:937-40 pubmed
    ..was to investigate the presence of strict anaerobes such as Filifactor alocis, Tannerella forsythia, and Treponema denticola in primary and secondary root-infected canals with periapical lesions by molecular analysis and the ..
  2. Izard J, Hsieh C, Limberger R, Mannella C, Marko M. Native cellular architecture of Treponema denticola revealed by cryo-electron tomography. J Struct Biol. 2008;163:10-7 pubmed publisher
    ..we are developing a refined description of native cellular structures in the pathogenic spirochete Treponema denticola. Tightly organized bundles of periplasmic flagella were readily observed in intact plunge-frozen cells...
  3. Yang Y, Stewart P, Shi X, Li C. Development of a transposon mutagenesis system in the oral spirochete Treponema denticola. Appl Environ Microbiol. 2008;74:6461-4 pubmed publisher
    Here, we report successful transposon mutagenesis in the oral spirochete Treponema denticola. A modified Himar1 transposon, including a new antibiotic selection cassette for T...
  4. Shibli J, Melo L, Ferrari D, Figueiredo L, Faveri M, Feres M. Composition of supra- and subgingival biofilm of subjects with healthy and diseased implants. Clin Oral Implants Res. 2008;19:975-82 pubmed publisher
    ..Higher mean counts of Porphyromonas gingivalis, Treponema denticola and Tannerella forsythia were observed in the peri-implantitis group, both supra- and subgingivally (P<0...
  5. Frederick J, Rogers E, Marconi R. Analysis of a growth-phase-regulated two-component regulatory system in the periodontal pathogen Treponema denticola. J Bacteriol. 2008;190:6162-9 pubmed publisher
    Nothing is currently known regarding the global regulatory networks of Treponema denticola and other oral spirochetes...
  6. Nussbaum G, Ben Adi S, Genzler T, Sela M, Rosen G. Involvement of Toll-like receptors 2 and 4 in the innate immune response to Treponema denticola and its outer sheath components. Infect Immun. 2009;77:3939-47 pubmed publisher
    b>Treponema denticola is considered an important oral pathogen in the development and progression of periodontal diseases. In the present study, the mechanisms of recognition and activation of murine macrophages by T...
  7. Cavrini F, Sambri V, Moter A, Servidio D, Marangoni A, Montebugnoli L, et al. Molecular detection of Treponema denticola and Porphyromonas gingivalis in carotid and aortic atheromatous plaques by FISH: report of two cases. J Med Microbiol. 2005;54:93-6 pubmed
    b>Treponema denticola and Porphyromonas gingivalis have been identified in atheromatous plaques of two patients suffering from atherosclerosis by PCR and fluorescence in situ hybridization (FISH)...
  8. Edwards A, Jenkinson H, Woodward M, Dymock D. Binding properties and adhesion-mediating regions of the major sheath protein of Treponema denticola ATCC 35405. Infect Immun. 2005;73:2891-8 pubmed
    There is growing evidence that a number of oral Treponema species, in particular Treponema denticola, are associated with the progression of human periodontal disease. The major sheath (or surface) protein (Msp) of T...
  9. Kuramitsu H, Chen W, Ikegami A. Biofilm formation by the periodontopathic bacteria Treponema denticola and Porphyromonas gingivalis. J Periodontol. 2005;76:2047-51 pubmed
    ..Both Porphyromonas gingivalis and Treponema denticola are frequently associated together in these oral biofilms...
  10. Foschi F, Cavrini F, Montebugnoli L, Stashenko P, Sambri V, Prati C. Detection of bacteria in endodontic samples by polymerase chain reaction assays and association with defined clinical signs in Italian patients. Oral Microbiol Immunol. 2005;20:289-95 pubmed
    ..bacteria (Enterococcus faecalis, Porphyromonas gingivalis, Prevotella intermedia, Tannerella forsythensis, Treponema denticola) in infected root canals was studied using polymerase chain reaction (PCR) assays, and the association of ..
  11. Tucci S, Martin W. A novel prokaryotic trans-2-enoyl-CoA reductase from the spirochete Treponema denticola. FEBS Lett. 2007;581:1561-6 pubmed publisher
    An NADH-dependent trans-2-enoyl-CoA reductase (EC1.1.1.36) from the Gram negative spirochete Treponema denticola was identified, expressed and biochemically characterized...
  12. Shin J, Ji S, Choi Y. Ability of oral bacteria to induce tissue-destructive molecules from human neutrophils. Oral Dis. 2008;14:327-34 pubmed
    ..The aim of this study was to determine whether the ability to stimulate neutrophils is an authentic characteristic of periodontopathic bacteria...
  13. Zainal Abidin Z, Veith P, Dashper S, Zhu Y, Catmull D, Chen Y, et al. Differential proteomic analysis of a polymicrobial biofilm. J Proteome Res. 2012;11:4449-64 pubmed publisher
    Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia exist in a polymicrobial biofilm associated with chronic periodontitis...
  14. Haffajee A, Teles R, Socransky S. Association of Eubacterium nodatum and Treponema denticola with human periodontitis lesions. Oral Microbiol Immunol. 2006;21:269-82 pubmed
  15. Zhu Y, Dashper S, Chen Y, Crawford S, Slakeski N, Reynolds E. Porphyromonas gingivalis and Treponema denticola synergistic polymicrobial biofilm development. PLoS ONE. 2013;8:e71727 pubmed publisher
    ..Porphyromonas gingivalis, Treponema denticola and Tannerella forsythia have all been implicated as playing roles in disease progression. P...
  16. Yoshida A, Nagashima S, Ansai T, Tachibana M, Kato H, Watari H, et al. Loop-mediated isothermal amplification method for rapid detection of the periodontopathic bacteria Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola. J Clin Microbiol. 2005;43:2418-24 pubmed
    ..the rapid detection of the major periodontal pathogens Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola. The LAMP method amplifies DNA with high specificity, efficiency, and rapidity under isothermal conditions ..
  17. Yamada M, Ikegami A, Kuramitsu H. Synergistic biofilm formation by Treponema denticola and Porphyromonas gingivalis. FEMS Microbiol Lett. 2005;250:271-7 pubmed
    ..In this study, in vitro biofilm formation by Treponema denticola and Porphyromonas gingivalis 381 displayed synergistic effects. Confocal microscopy demonstrated that P...
  18. Gaibani P, Pellegrino M, Rossini G, Alvisi G, Miragliotta L, Prati C, et al. The central region of the msp gene of Treponema denticola has sequence heterogeneity among clinical samples, obtained from patients with periodontitis. BMC Infect Dis. 2010;10:345 pubmed publisher
    b>Treponema denticola is an oral spirochete involved in the pathogenesis and progression of periodontal disease. Of its virulence factors, the major surface protein (MSP) plays a role in the interaction between the treponeme and host...
  19. Bian J, Shen H, Tu Y, Yu A, Li C. The riboswitch regulates a thiamine pyrophosphate ABC transporter of the oral spirochete Treponema denticola. J Bacteriol. 2011;193:3912-22 pubmed publisher
    ..The oral spirochete Treponema denticola is an important pathogen that is associated with human periodontal diseases...
  20. Bian J, Liu X, Cheng Y, Li C. Inactivation of cyclic Di-GMP binding protein TDE0214 affects the motility, biofilm formation, and virulence of Treponema denticola. J Bacteriol. 2013;195:3897-905 pubmed publisher
    ..The oral spirochete Treponema denticola, a periodontal pathogen associated with human periodontitis, has a complex c-di-GMP signaling network...
  21. Laugisch O, Schacht M, Guentsch A, Kantyka T, Sroka A, Stennicke H, et al. Periodontal pathogens affect the level of protease inhibitors in gingival crevicular fluid. Mol Oral Microbiol. 2012;27:45-56 pubmed publisher
    ..Finally loads of P. gingivalis, Aggregatibacter actinomycetemcomitans, Tannerella forsythia and Treponema denticola were determined...
  22. Jackson Rosario S, Self W. Inhibition of selenium metabolism in the oral pathogen Treponema denticola. J Bacteriol. 2009;191:4035-40 pubmed publisher
    In this report we provide evidence that the antimicrobial action of stannous salts and a gold drug, auranofin, against Treponema denticola is mediated through inhibition of the metabolism of selenium for synthesis of selenoproteins.
  23. Ji S, Kim Y, Min B, Han S, Choi Y. Innate immune responses of gingival epithelial cells to nonperiodontopathic and periodontopathic bacteria. J Periodontal Res. 2007;42:503-10 pubmed
  24. Dashper S, Seers C, Tan K, Reynolds E. Virulence factors of the oral spirochete Treponema denticola. J Dent Res. 2011;90:691-703 pubmed publisher
    ..Chronic periodontitis is a polymicrobial disease, and recent animal studies indicate that co-infection of Treponema denticola with other periodontal pathogens can enhance alveolar bone resorption...
  25. Miyamoto M, Ishihara K, Okuda K. The Treponema denticola surface protease dentilisin degrades interleukin-1 beta (IL-1 beta), IL-6, and tumor necrosis factor alpha. Infect Immun. 2006;74:2462-7 pubmed
    Dentilisin is a major surface protease and virulence factor of the bacterium Treponema denticola. In this study, we found that T...
  26. Gaibani P, Caroli F, Nucci C, Sambri V. Major surface protein complex of Treponema denticola induces the production of tumor necrosis factor alpha, interleukin-1 beta, interleukin-6 and matrix metalloproteinase 9 by primary human peripheral blood monocytes. J Periodontal Res. 2010;45:361-6 pubmed publisher
    b>Treponema denticola is a micro-organism that is involved in the pathogenesis of periodontitis. Major surface protein complex (MSPc), which is expressed on the envelope of this treponeme, plays a key role in the interaction between T...
  27. Cellini B, Bertoldi M, Montioli R, Borri Voltattorni C. Probing the role of Tyr 64 of Treponema denticola cystalysin by site-directed mutagenesis and kinetic studies. Biochemistry. 2005;44:13970-80 pubmed
    Tyr 64, hydrogen-bonded to coenzyme phosphate in Treponema denticola cystalysin, was changed to alanine by site-directed mutagenesis...
  28. McDowell J, Lankford J, Stamm L, Sadlon T, Gordon D, Marconi R. Demonstration of factor H-like protein 1 binding to Treponema denticola, a pathogen associated with periodontal disease in humans. Infect Immun. 2005;73:7126-32 pubmed
    b>Treponema denticola is an important contributor to periodontal disease. In this study we investigated the ability of T. denticola to bind the complement regulatory proteins factor H and factor H-like protein 1 (FHL-1)...
  29. Rudney J, Chen R, Zhang G. Streptococci dominate the diverse flora within buccal cells. J Dent Res. 2005;84:1165-71 pubmed
    ..identify Fusobacterium nucleatum, Prevotella intermedia, oral Campylobacter species, Eikenella corrodens, Treponema denticola, Gemella haemolysans, Granulicatella adiacens, and total streptococci within buccal epithelial cells...
  30. Bodet C, Chandad F, Grenier D. [Pathogenic potential of Porphyromonas gingivalis, Treponema denticola and Tannerella forsythia, the red bacterial complex associated with periodontitis]. Pathol Biol (Paris). 2007;55:154-62 pubmed
    ..in the oral cavity, a bacterial complex named "red complex" and made of Porphyromonas gingivalis, Treponema denticola and Tannerella forsythia has been strongly related to advanced periodontal lesions...
  31. Fukamachi H, Nakano Y, Okano S, Shibata Y, Abiko Y, Yamashita Y. High production of methyl mercaptan by L-methionine-alpha-deamino-gamma-mercaptomethane lyase from Treponema denticola. Biochem Biophys Res Commun. 2005;331:127-31 pubmed
    ..We found that Treponema denticola, a member of the subgingival biofilm at periodontal disease sites, produced a large amount of methyl ..
  32. Goetting Minesky M, Godovikova V, Li J, Seshadrinathan S, Timm J, Kamodia S, et al. Conservation and revised annotation of the Treponema denticola prcB-prcA-prtP locus encoding the dentilisin (CTLP) protease complex. Mol Oral Microbiol. 2013;28:181-91 pubmed publisher
    ..b>Treponema denticola exhibits considerable interstrain variability in its major surface protein (Msp), but no studies have ..
  33. Ellen R, Galimanas V. Spirochetes at the forefront of periodontal infections. Periodontol 2000. 2005;38:13-32 pubmed
  34. Bodet C, Chandad F, Grenier D. Inflammatory responses of a macrophage/epithelial cell co-culture model to mono and mixed infections with Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia. Microbes Infect. 2006;8:27-35 pubmed
    Accumulated evidence points to Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia as three major etiologic agents of chronic periodontitis...
  35. McDowell J, Huang B, Fenno J, Marconi R. Analysis of a unique interaction between the complement regulatory protein factor H and the periodontal pathogen Treponema denticola. Infect Immun. 2009;77:1417-25 pubmed publisher
    b>Treponema denticola, a spirochete associated with periodontitis, is abundant at the leading edge of subgingival plaque, where it interacts with gingival epithelia. T...
  36. Bernardini C, Gaibani P, Zannoni A, Vocale C, Bacci M, Piana G, et al. Treponema denticola alters cell vitality and induces HO-1 and Hsp70 expression in porcine aortic endothelial cells. Cell Stress Chaperones. 2010;15:509-16 pubmed publisher
    b>Treponema denticola is an oral spirochete that is associated with periodontal disease and detected occasionally in extraoral lesions associated with systemic disorders such as cardiovascular diseases...
  37. Shin J, Kim Y, Oh J, Min B, Choi Y. Treponema denticola suppresses expression of human {beta}-defensin-3 in gingival epithelial cells through inhibition of the toll-like receptor 2 axis. Infect Immun. 2010;78:672-9 pubmed publisher
    We reported previously that Treponema denticola, one of the periodontal pathogens, suppresses the expression of human beta-defensins (HBDs) in human gingival epithelial cells...
  38. Holt S, Ebersole J. Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia: the "red complex", a prototype polybacterial pathogenic consortium in periodontitis. Periodontol 2000. 2005;38:72-122 pubmed
  39. Veith P, Dashper S, O Brien Simpson N, Paolini R, Orth R, Walsh K, et al. Major proteins and antigens of Treponema denticola. Biochim Biophys Acta. 2009;1794:1421-32 pubmed publisher
    b>Treponema denticola is a Gram-negative, motile, asaccharolytic, anaerobic spirochaete which along with Porphyromonas gingivalis and Tannerella forsythia has been shown to form a bacterial consortium called the Red Complex that is ..
  40. Gaibani P, Vocale C, Ambretti S, Cavrini F, Izard J, Miragliotta L, et al. Killing of Treponema denticola by mouse peritoneal macrophages. J Dent Res. 2010;89:521-6 pubmed publisher
    b>Treponema denticola has been identified as an important cause of periodontal disease and hypothesized to be involved in extra-oral infections. The objective of this study was to investigate the role of T...
  41. Brett P, Burtnick M, Fenno J, Gherardini F. Treponema denticola TroR is a manganese- and iron-dependent transcriptional repressor. Mol Microbiol. 2008;70:396-409 pubmed publisher
    b>Treponema denticola harbours a genetic locus with significant homology to most of the previously characterized Treponema pallidum tro operon...
  42. Kesavalu L, Sathishkumar S, Bakthavatchalu V, Matthews C, Dawson D, Steffen M, et al. Rat model of polymicrobial infection, immunity, and alveolar bone resorption in periodontal disease. Infect Immun. 2007;75:1704-12 pubmed
    ..Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia have been strongly implicated as members of a pathogenic consortium in the ..
  43. Miao D, Fenno J, Timm J, Joo N, Kapila Y. The Treponema denticola chymotrypsin-like protease dentilisin induces matrix metalloproteinase-2-dependent fibronectin fragmentation in periodontal ligament cells. Infect Immun. 2011;79:806-11 pubmed publisher
    ..While their precise roles are not well understood, periodontal pathogens, including Treponema denticola, are believed to initiate the destructive inflammatory responses and dysregulation of tissue homeostasis ..
  44. Clark D, Soory M. The influence of cholesterol, progesterone, 4-androstenedione and testosterone on the growth of Treponema denticola ATCC 33520 in batch cultures. Anaerobe. 2006;12:267-73 pubmed
    Previously, we have shown that reference and freshly isolated Treponema denticola cultures are capable of metabolising cholesterol, progesterone, 4-androstenedione and testosterone by means of 5alpha-reductase, 3beta-and 17beta-..
  45. Lai Y, Chu L. Novel mechanism for conditional aerobic growth of the anaerobic bacterium Treponema denticola. Appl Environ Microbiol. 2008;74:73-9 pubmed
    b>Treponema denticola, a periodontal pathogen, has recently been shown to exhibit properties of a facultative anaerobic spirochete, in contrast to its previous recognition as an obligate anaerobic bacterium...
  46. Chu L, Lai Y, Xu X, Eddy S, Yang S, Song L, et al. A 52-kDa leucyl aminopeptidase from treponema denticola is a cysteinylglycinase that mediates the second step of glutathione metabolism. J Biol Chem. 2008;283:19351-8 pubmed publisher
    The metabolism of glutathione by the periodontal pathogen Treponema denticola produces hydrogen sulfide, which may play a role in the host tissue destruction seen in periodontitis...
  47. Mo S, You M, Su Y, Lacap Bugler D, Huo Y, Smith G, et al. Multilocus sequence analysis of Treponema denticola strains of diverse origin. BMC Microbiol. 2013;13:24 pubmed publisher
    The oral spirochete bacterium Treponema denticola is associated with both the incidence and severity of periodontal disease. Although the biological or phenotypic properties of a significant number of T...
  48. Goetting Minesky M, Fenno J. A simplified erythromycin resistance cassette for Treponema denticola mutagenesis. J Microbiol Methods. 2010;83:66-8 pubmed publisher
    The primary selectable marker for the genetic studies of Treponema denticola is a hybrid gene cassette containing both ermF and ermAM (ermB) genes. ErmB functions in Escherichia coli, while ErmF has been assumed to confer resistance in T...
  49. Ruby J, Lux R, Shi W, Charon N, Dasanayake A. Effect of glucose on Treponema denticola cell behavior. Oral Microbiol Immunol. 2008;23:234-8 pubmed publisher
    b>Treponema denticola inhabits the oral subgingival environment and is part of a proteolytic benzoyl-dl-arginine-naphthylamide-positive 'red complex' associated with active periodontal disease...
  50. Cogoni V, Morgan Smith A, Fenno J, Jenkinson H, Dymock D. Treponema denticola chymotrypsin-like proteinase (CTLP) integrates spirochaetes within oral microbial communities. Microbiology. 2012;158:759-70 pubmed publisher
    b>Treponema denticola is found ubiquitously in the human oral cavity and is mainly associated with bacterial communities implicated in the establishment and development of periodontal disease...
  51. Godovikova V, Wang H, Goetting Minesky M, Ning Y, Capone R, Slater C, et al. Treponema denticola PrcB is required for expression and activity of the PrcA-PrtP (dentilisin) complex. J Bacteriol. 2010;192:3337-44 pubmed publisher
    The Treponema denticola surface protease complex, consisting of PrtP protease (dentilisin) and two auxiliary polypeptides (PrcA1 and PrcA2), is believed to contribute to periodontal disease by degrading extracellular matrix components ..
  52. Coleman N, Tetu S, Wilson N, Holmes A. An unusual integron in Treponema denticola. Microbiology. 2004;150:3524-6 pubmed
  53. Darveau R. Periodontitis: a polymicrobial disruption of host homeostasis. Nat Rev Microbiol. 2010;8:481-90 pubmed publisher
    ..species found in plaque (the 'red-complex' bacteria: Porphyromonas gingivalis, Tannerella forsythia and Treponema denticola) use various mechanisms to interfere with host defence mechanisms...
  54. Foschi F, Izard J, Sasaki H, Sambri V, Prati C, Muller R, et al. Treponema denticola in disseminating endodontic infections. J Dent Res. 2006;85:761-5 pubmed
    b>Treponema denticola is a consensus periodontal pathogen that has recently been associated with endodontic pathology. In this study, the effect of mono-infection of the dental pulp with T...
  55. Bamford C, Francescutti T, Cameron C, Jenkinson H, Dymock D. Characterization of a novel family of fibronectin-binding proteins with M23 peptidase domains from Treponema denticola. Mol Oral Microbiol. 2010;25:369-83 pubmed publisher
    ..The periodontitis-associated oral spirochaete Treponema denticola expresses at least two fibronectin-binding proteins, designated Msp (major surface protein) and OppA (..
  56. Kurniyati K, Zhang W, Zhang K, Li C. A surface-exposed neuraminidase affects complement resistance and virulence of the oral spirochaete Treponema denticola. Mol Microbiol. 2013;89:842-56 pubmed publisher
    ..Herein, a putative neuraminidase (TDE0471) was identified in Treponema denticola, an oral spirochaete associated with human periodontitis...
  57. Shin J, Choi Y. Treponema denticola suppresses expression of human beta-defensin-2 in gingival epithelial cells through inhibition of TNFalpha production and TLR2 activation. Mol Cells. 2010;29:407-12 pubmed publisher
    We previously reported that Treponema denticola, a periodontal pathogen, suppressed the expression of human beta-defensins (HBDs) and IL-8 in human gingival epithelial cells...
  58. Rosen G, Genzler T, Sela M. Coaggregation of Treponema denticola with Porphyromonas gingivalis and Fusobacterium nucleatum is mediated by the major outer sheath protein of Treponema denticola. FEMS Microbiol Lett. 2008;289:59-66 pubmed publisher
    Coagreggation of Treponema denticola with either Porphyromonas gingivalis or Fusobacterium nucleatum was characterized and the role of the major outer sheath protein (MSP) in the coaggregation process of these bacteria was evaluated...
  59. Choi B, Moon S, Cha J, Kim K, Yoo Y. Prostaglandin E(2) is a main mediator in receptor activator of nuclear factor-kappaB ligand-dependent osteoclastogenesis induced by Porphyromonas gingivalis, Treponema denticola, and Treponema socranskii. J Periodontol. 2005;76:813-20 pubmed
    ..To understand the mechanism of how periodontopathogens induce osteoclastogenesis, we determined which mediators are involved in the osteoclastogenesis...
  60. Mitchell H, Dashper S, Catmull D, Paolini R, Cleal S, Slakeski N, et al. Treponema denticola biofilm-induced expression of a bacteriophage, toxin-antitoxin systems and transposases. Microbiology. 2010;156:774-88 pubmed publisher
    b>Treponema denticola is an oral spirochaete that has been strongly associated with chronic periodontitis. The bacterium exists as part of a dense biofilm (subgingival dental plaque) accreted to the tooth. To determine T...
  61. Magalhaes M, Sun C, Glogauer M, Ellen R. The major outer sheath protein of Treponema denticola selectively inhibits Rac1 activation in murine neutrophils. Cell Microbiol. 2008;10:344-54 pubmed
    b>Treponema denticola major outer sheath protein (Msp) inhibits neutrophil chemotaxis in vitro, but key regulatory mechanisms have not been identified...
  62. Capone R, Wang H, Ning Y, Sweier D, Lopatin D, Fenno J. Human serum antibodies recognize Treponema denticola Msp and PrtP protease complex proteins. Oral Microbiol Immunol. 2008;23:165-9 pubmed publisher
    b>Treponema denticola outer membrane proteins are postulated to have key roles in microbe-host interactions in periodontitis. Because there are no reports of in vivo expression of these putative virulence factors, we examined several T...
  63. Rosen G, Sela M, Bachrach G. The antibacterial activity of LL-37 against Treponema denticola is dentilisin protease independent and facilitated by the major outer sheath protein virulence factor. Infect Immun. 2012;80:1107-14 pubmed publisher
    ..b>Treponema denticola is an oral anaerobic spirochete closely associated with the pathogenesis of periodontal disease. The T...
  64. Godovikova V, Goetting Minesky M, Fenno J. Composition and localization of Treponema denticola outer membrane complexes. Infect Immun. 2011;79:4868-75 pubmed publisher
    The Treponema denticola outer membrane lipoprotein-protease complex (dentilisin) contributes to periodontal disease by degrading extracellular matrix components and disrupting intercellular host signaling pathways...
  65. Ammann T, Bostanci N, Belibasakis G, Thurnheer T. Validation of a quantitative real-time PCR assay and comparison with fluorescence microscopy and selective agar plate counting for species-specific quantification of an in vitro subgingival biofilm model. J Periodontal Res. 2013;48:517-26 pubmed publisher
  66. Clark D, Soory M. The metabolism of cholesterol and certain hormonal steroids by Treponema denticola. Steroids. 2006;71:352-63 pubmed
    The aim was to investigate whether reference cultures and fresh isolates of Treponema denticola are able to 5alpha-reduce and further metabolise testosterone, 4-androstenedione, progesterone, corticosterone, cortisol or cholesterol...
  67. Anand A, Luthra A, Edmond M, Ledoyt M, Caimano M, Radolf J. The major outer sheath protein (Msp) of Treponema denticola has a bipartite domain architecture and exists as periplasmic and outer membrane-spanning conformers. J Bacteriol. 2013;195:2060-71 pubmed publisher
    The major outer sheath protein (Msp) is a primary virulence determinant in Treponema denticola, as well as the parental ortholog for the Treponema pallidum repeat (Tpr) family in the syphilis spirochete...
  68. McDowell J, Frederick J, Stamm L, Marconi R. Identification of the gene encoding the FhbB protein of Treponema denticola, a highly unique factor H-like protein 1 binding protein. Infect Immun. 2007;75:1050-4 pubmed publisher
    The gene encoding the Treponema denticola factor H-like protein 1 (FHL-1) binding protein, FhbB, was recovered and characterized. Sequence conservation, expression, and properties of FhbB were analyzed...
  69. Mchardy I, Keegan C, Sim J, Shi W, Lux R. Transcriptional profiles of Treponema denticola in response to environmental conditions. PLoS ONE. 2010;5:e13655 pubmed publisher
    ..In summary, stress responses in T. denticola exhibit many similarities to the corresponding stress responses in other organisms but also employ unique components including the induction of hypothetical proteins...
  70. Ito R, Ishihara K, Shoji M, Nakayama K, Okuda K. Hemagglutinin/Adhesin domains of Porphyromonas gingivalis play key roles in coaggregation with Treponema denticola. FEMS Immunol Med Microbiol. 2010;60:251-60 pubmed publisher
    Porphyromonas gingivalis and Treponema denticola are major pathogens of periodontal disease...
  71. Byrne S, Dashper S, Darby I, Adams G, Hoffmann B, Reynolds E. Progression of chronic periodontitis can be predicted by the levels of Porphyromonas gingivalis and Treponema denticola in subgingival plaque. Oral Microbiol Immunol. 2009;24:469-77 pubmed publisher
  72. Kim M, Jun H, Choi B, Cha J, Yoo Y. Td92, an outer membrane protein of Treponema denticola, induces osteoclastogenesis via prostaglandin E(2)-mediated RANKL/osteoprotegerin regulation. J Periodontal Res. 2010;45:772-9 pubmed publisher
    ..Td92 is a surface-exposed outer membrane protein of Treponema denticola, a periodontopathogen...
  73. Ishihara K, Wawrzonek K, Shaw L, Inagaki S, Miyamoto M, Potempa J. Dentipain, a Streptococcus pyogenes IdeS protease homolog, is a novel virulence factor of Treponema denticola. Biol Chem. 2010;391:1047-55 pubmed publisher
    b>Treponema denticola is a major pathogen of chronic periodontitis. Analysis of the T. denticola genome revealed a gene orthologous with a cysteine protease-encoding gene from Streptococcus pyogenes (IdeS)...
  74. Martínez Pabón M, Martínez Gaviria A, Isaza Guzmán D, Muskus López C, Tobón Arroyave S. Confounding and interaction effect of Treponema denticola salivary carriage in chronic periodontitis. Oral Dis. 2010;16:278-85 pubmed publisher
    To evaluate the salivary carriage of Treponema denticola and its association with demographic variables in the etiopathogenesis of chronic periodontitis.
  75. Cellini B, Bertoldi M, Montioli R, Laurents D, Paiardini A, Voltattorni C. Dimerization and folding processes of Treponema denticola cystalysin: the role of pyridoxal 5'-phosphate. Biochemistry. 2006;45:14140-54 pubmed
    Cystalysin, the key virulence factor in the bacterium Treponema denticola responsible for periodontitis, is a homodimeric pyridoxal 5'-phosphate (PLP)-C-S lyase...
  76. Puthengady Thomas B, Sun C, Bajenova E, Ellen R, Glogauer M. Modulation of human neutrophil functions in vitro by Treponema denticola major outer sheath protein. Infect Immun. 2006;74:1954-7 pubmed
    In this study of human polymorphonuclear leukocytes (PMNs), pretreatment with Treponema denticola major outer sheath protein (Msp) inhibited formyl-methionyl-leucyl-phenylalanine (fMLP)-induced chemotaxis, phagocytosis of immunoglobulin ..
  77. Lee J, Yi N, Kim U, Choi J, Kim S, Choi J. Porphyromonas gingivalis heat shock protein vaccine reduces the alveolar bone loss induced by multiple periodontopathogenic bacteria. J Periodontal Res. 2006;41:10-4 pubmed
    ..The present study was performed to evaluate Porphyromonas gingivalis heat shock protein 60 (HSP60) as a vaccine candidate to inhibit multiple bacteria-induced alveolar bone loss...
  78. Bian X, Wang H, Ning Y, Lee S, Fenno J. Mutagenesis of a novel gene in the prcA-prtP protease locus affects expression of Treponema denticola membrane complexes. Infect Immun. 2005;73:1252-5 pubmed publisher
    A novel gene was identified in the Treponema denticola prcA-prtP protease operon. Strains with mutations in either the prcA-prtP or the msp region showed altered expression of a product(s) of the other locus...
  79. Bamford C, Fenno J, Jenkinson H, Dymock D. The chymotrypsin-like protease complex of Treponema denticola ATCC 35405 mediates fibrinogen adherence and degradation. Infect Immun. 2007;75:4364-72 pubmed
    b>Treponema denticola is an anaerobic spirochete strongly associated with human periodontal disease. T. denticola bacteria interact with a range of host tissue proteins, including fibronectin, laminin, and fibrinogen...
  80. Orth R, O Brien Simpson N, Dashper S, Reynolds E. Synergistic virulence of Porphyromonas gingivalis and Treponema denticola in a murine periodontitis model. Mol Oral Microbiol. 2011;26:229-40 pubmed publisher
    ..associated with the presence of a subgingival polymicrobial biofilm containing Porphyromonas gingivalis and Treponema denticola. We have investigated the potential synergistic virulence of P. gingivalis and T...
  81. Tamura K, Nakano K, Hayashibara T, Nomura R, Fujita K, Shintani S, et al. Distribution of 10 periodontal bacteria in saliva samples from Japanese children and their mothers. Arch Oral Biol. 2006;51:371-7 pubmed
    ..corrodens, Actinobacillus actinomycetemcomitans, Capnocytophaga ochracea, Capnocytophaga sputigena, and Treponema denticola) in children, and then compared their distribution in those children and their mothers, with special ..
  82. McDowell J, Frederick J, Miller D, Goetting Minesky M, Goodman H, Fenno J, et al. Identification of the primary mechanism of complement evasion by the periodontal pathogen, Treponema denticola. Mol Oral Microbiol. 2011;26:140-9 pubmed publisher
    b>Treponema denticola, a periodontal pathogen, binds the complement regulatory protein Factor H (FH). Factor H binding protein B (FhbB) is the sole FH binding protein produced by T. denticola...
  83. Tamai R, Deng X, Kiyoura Y. Porphyromonas gingivalis with either Tannerella forsythia or Treponema denticola induces synergistic IL-6 production by murine macrophage-like J774.1 cells. Anaerobe. 2009;15:87-90 pubmed publisher
    ..Porphyromonas gingivalis, Tannerella forsythia and Treponema denticola are frequently detected in deep periodontal pockets...
  84. Nahid M, Rivera M, Lucas A, Chan E, Kesavalu L. Polymicrobial infection with periodontal pathogens specifically enhances microRNA miR-146a in ApoE-/- mice during experimental periodontal disease. Infect Immun. 2011;79:1597-605 pubmed publisher
    Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia are periodontal pathogens associated with the etiology of adult periodontitis as polymicrobial infections. Recent studies demonstrated that oral infection with P...
  85. Lee S, Andrian E, Rowland E, Marquez I. Immune response and alveolar bone resorption in a mouse model of Treponema denticola infection. Infect Immun. 2009;77:694-8 pubmed publisher
    b>Treponema denticola is considered to be an agent strongly associated with periodontal disease. The lack of an animal infection model has hampered the understanding of T. denticola pathogenesis and the host's immune response to infection...