borrelia burgdorferi

Summary

Summary: A specific species of bacteria, part of the BORRELIA BURGDORFERI GROUP, whose common name is Lyme disease spirochete.

Top Publications

  1. Cohn K, Thompson A, Shah S, Hines E, Lyons T, Welsh E, et al. Validation of a clinical prediction rule to distinguish Lyme meningitis from aseptic meningitis. Pediatrics. 2012;129:e46-53 pubmed publisher
    ..The goal of this study was to test the performance of the Rule of 7's in a multicenter cohort of children with CSF pleocytosis...
  2. He M, Zhang J, Ye M, Lou Y, Yang X. Cyclic Di-GMP receptor PlzA controls virulence gene expression through RpoS in Borrelia burgdorferi. Infect Immun. 2014;82:445-52 pubmed publisher
    As an obligate pathogen, the Lyme disease spirochete Borrelia burgdorferi has a streamlined genome that encodes only two two-component signal transduction systems, Hk1-Rrp1 and Hk2-Rrp2 (in addition to CheA-CheY systems)...
  3. Dolan M, Schulze T, Jordan R, Dietrich G, Schulze C, Hojgaard A, et al. Elimination of Borrelia burgdorferi and Anaplasma phagocytophilum in rodent reservoirs and Ixodes scapularis ticks using a doxycycline hyclate-laden bait. Am J Trop Med Hyg. 2011;85:1114-20 pubmed publisher
    ..protect and cure small-mammal reservoirs and reduce infection rates in questing Ixodes scapularis ticks for Borrelia burgdorferi and Anaplasma phagocytophilum...
  4. Wagner B, Erb H. Dogs and horses with antibodies to outer-surface protein C as on-time sentinels for ticks infected with Borrelia burgdorferi in New York State in 2011. Prev Vet Med. 2012;107:275-9 pubmed publisher
    Reported cases of Lyme disease (a chronic disease caused by infection with Borrelia burgdorferi) in humans increased more than two-fold between 1992 and 2006 in the United States...
  5. Liveris D, Schwartz I, McKenna D, Nowakowski J, Nadelman R, DeMarco J, et al. Quantitation of cell-associated borrelial DNA in the blood of Lyme disease patients with erythema migrans. Eur J Clin Microbiol Infect Dis. 2012;31:791-5 pubmed publisher
    ..This study was designed to measure the level of Borrelia burgdorferi in the plasma of Lyme disease patients and correlate these levels with selected clinical and laboratory ..
  6. Sytykiewicz H, Karbowiak G, Werszko J, Czerniewicz P, Sprawka I, Mitrus J. Molecular screening for Bartonella henselae and Borrelia burgdorferi sensu lato co-existence within Ixodes ricinus populations in central and eastern parts of Poland. Ann Agric Environ Med. 2012;19:451-6 pubmed
    The presented study aimed at establishing the prevalence and co-infection rates of Bartonella henselae and Borrelia burgdorferi sensu lato in Ixodes ricinus ticks collected from the central and eastern parts of Poland...
  7. LaRocca T, Pathak P, Chiantia S, Toledo A, Silvius J, Benach J, et al. Proving lipid rafts exist: membrane domains in the prokaryote Borrelia burgdorferi have the same properties as eukaryotic lipid rafts. PLoS Pathog. 2013;9:e1003353 pubmed publisher
    ..These findings provide compelling evidence for the existence of lipid rafts and show that the same principles of lipid raft formation apply to prokaryotes and eukaryotes despite marked differences in their lipid compositions...
  8. Kern A, Collin E, Barthel C, Michel C, Jaulhac B, Boulanger N. Tick saliva represses innate immunity and cutaneous inflammation in a murine model of Lyme disease. Vector Borne Zoonotic Dis. 2011;11:1343-50 pubmed publisher
    ..We conclude that Borrelia pathogens specifically use the tick saliva to facilitate their transmission to the host and that the skin constitutes an essential interface in the development of Lyme disease. ..
  9. Ramesh G, Benge S, Pahar B, Philipp M. A possible role for inflammation in mediating apoptosis of oligodendrocytes as induced by the Lyme disease spirochete Borrelia burgdorferi. J Neuroinflammation. 2012;9:72 pubmed publisher
    ..As oligodendrocytes are vital for the functioning and survival of neurons, the inflammation and subsequent apoptosis of oligodendrocytes induced by B. burgdorferi could contribute to the pathogenesis of Lyme neuroborreliosis. ..

More Information

Publications149 found, 100 shown here

  1. Xia Z, Yu D, Mao J, Zhang Z, Yu J. The occurrence of Dirofilaria immitis, Borrelia burgdorferi, Ehrlichia canis and Anaplasma phagocytophium in dogs in China. J Helminthol. 2012;86:185-9 pubmed publisher
    A survey of the occurrence of Dirofilaria immitis, Borrelia burgdorferi, Ehrlichia canis and Anaplasma phagocytophium in dogs was undertaken in the People's Republic of China between October 2008 and October 2009...
  2. Nogueira S, Smith A, Qin J, Pal U. A surface enolase participates in Borrelia burgdorferi-plasminogen interaction and contributes to pathogen survival within feeding ticks. Infect Immun. 2012;80:82-90 pubmed publisher
    b>Borrelia burgdorferi, a tick-borne bacterial pathogen, causes a disseminated infection involving multiple organs known as Lyme disease...
  3. Eggers C, Caimano M, Malizia R, Kariu T, Cusack B, Desrosiers D, et al. The coenzyme A disulphide reductase of Borrelia burgdorferi is important for rapid growth throughout the enzootic cycle and essential for infection of the mammalian host. Mol Microbiol. 2011;82:679-97 pubmed publisher
    In a microarray analysis of the RpoS regulon in mammalian host-adapted Borrelia burgdorferi, bb0728 (cdr) was found to be dually transcribed by the sigma factors ?(70) and RpoS...
  4. Sen E, Uchishima Y, Okamoto Y, Fukui T, Kadosaka T, Ohashi N, et al. Molecular detection of Anaplasma phagocytophilum and Borrelia burgdorferi in Ixodes ricinus ticks from Istanbul metropolitan area and rural Trakya (Thrace) region of north-western Turkey. Ticks Tick Borne Dis. 2011;2:94-8 pubmed publisher
    ..of human granulocytic anaplasmosis (HGA), Anaplasma phagocytophilum, and the agent of Lyme borreliosis, Borrelia burgdorferi sensu lato, in north-western Turkey...
  5. Jewett M, Jain S, Linowski A, Sarkar A, Rosa P. Molecular characterization of the Borrelia burgdorferi in vivo-essential protein PncA. Microbiology. 2011;157:2831-40 pubmed publisher
    ..In Borrelia burgdorferi, the nicotinamidase enzyme, PncA, is required for spirochaete survival throughout the infectious cycle...
  6. Wright S, Tucker J, Donohue A, Castro M, Kelley K, Novak M, et al. Avian hosts of Ixodes pacificus (Acari: Ixodidae) and the detection of Borrelia burgdorferi in larvae feeding on the Oregon junco. J Med Entomol. 2011;48:852-9 pubmed
    ..and nymphal ticks were removed and preserved for counting, examination and testing for the presence of Borrelia burgdorferi Johnson, Schmid, Hyde, Steigerwalt & Brenner. Mean infestations with I...
  7. Sapi E, Bastian S, Mpoy C, Scott S, Rattelle A, Pabbati N, et al. Characterization of biofilm formation by Borrelia burgdorferi in vitro. PLoS ONE. 2012;7:e48277 pubmed publisher
    b>Borrelia burgdorferi, the causative agent of Lyme disease, has long been known to be capable of forming aggregates and colonies...
  8. Nadelman R, Hanincová K, Mukherjee P, Liveris D, Nowakowski J, McKenna D, et al. Differentiation of reinfection from relapse in recurrent Lyme disease. N Engl J Med. 2012;367:1883-90 pubmed publisher
    ..We used molecular typing of Borrelia burgdorferi isolates obtained from patients with culture-confirmed episodes of erythema migrans to distinguish between ..
  9. Miller C, Karna S, Seshu J. Borrelia host adaptation Regulator (BadR) regulates rpoS to modulate host adaptation and virulence factors in Borrelia burgdorferi. Mol Microbiol. 2013;88:105-24 pubmed publisher
    The RpoS transcription factor of Borrelia burgdorferi is a 'gatekeeper' because it activates genes required for spirochaetes to transition from tick to vertebrate hosts...
  10. Groshong A, Blevins J. Insights into the biology of Borrelia burgdorferi gained through the application of molecular genetics. Adv Appl Microbiol. 2014;86:41-143 pubmed publisher
    b>Borrelia burgdorferi, the vector-borne bacterium that causes Lyme disease, was first identified in 1982...
  11. Pappas C, Iyer R, Petzke M, Caimano M, Radolf J, Schwartz I. Borrelia burgdorferi requires glycerol for maximum fitness during the tick phase of the enzootic cycle. PLoS Pathog. 2011;7:e1002102 pubmed publisher
    b>Borrelia burgdorferi, the spirochetal agent of Lyme disease, is a vector-borne pathogen that cycles between a mammalian host and tick vector...
  12. Jutras B, Verma A, Adams C, Brissette C, Burns L, Whetstine C, et al. BpaB and EbfC DNA-binding proteins regulate production of the Lyme disease spirochete's infection-associated Erp surface proteins. J Bacteriol. 2012;194:778-86 pubmed publisher
    ..The Lyme disease agent, Borrelia burgdorferi, produces Erp surface proteins throughout mammalian infection and represses their synthesis during ..
  13. Sze C, Morado D, Liu J, Charon N, Xu H, Li C. Carbon storage regulator A (CsrA(Bb)) is a repressor of Borrelia burgdorferi flagellin protein FlaB. Mol Microbiol. 2011;82:851-64 pubmed publisher
    The Lyme disease spirochete Borrelia burgdorferi lacks the transcriptional cascade control of flagellar protein synthesis common to other bacteria. Instead, it relies on a post-transcriptional mechanism to control its flagellar synthesis...
  14. Brisson D, Drecktrah D, Eggers C, Samuels D. Genetics of Borrelia burgdorferi. Annu Rev Genet. 2012;46:515-36 pubmed publisher
    The spirochetes in the Borrelia burgdorferi sensu lato genospecies group cycle in nature between tick vectors and vertebrate hosts. The current assemblage of B...
  15. Coleman J, Crowley J, Toledo A, Benach J. The HtrA protease of Borrelia burgdorferi degrades outer membrane protein BmpD and chemotaxis phosphatase CheX. Mol Microbiol. 2013;88:619-33 pubmed publisher
    b>Borrelia burgdorferi, the spirochaetal agent of Lyme disease, codes for a single HtrA protein, HtrABb (BB0104) that is homologous to DegP of Escherichia coli (41% amino acid identity)...
  16. Pozsgay V, Kubler Kielb J, Coxon B, Marques A, Robbins J, Schneerson R. Synthesis and antigenicity of BBGL-2 glycolipids of Borrelia burgdorferi, the causative agent of Lyme disease. Carbohydr Res. 2011;346:1551-63 pubmed publisher
    b>Borrelia burgdorferi is the etiological agent for Lyme disease (LD), the most common vector borne disease in the United States. There is no human vaccine against LD currently available...
  17. Salman Dilgimen A, Hardy P, Dresser A, Chaconas G. HrpA, a DEAH-box RNA helicase, is involved in global gene regulation in the Lyme disease spirochete. PLoS ONE. 2011;6:e22168 pubmed publisher
    ..This finding is particularly timely with the recent growth of the field of RNA regulation of gene expression and the ability of RNA helicases to modulate RNA structure and function. ..
  18. Rodríguez I, Fernandez C, Sanchez L, Martinez B, Siegrist H, Lienhard R. Prevalence of antibodies to Borrelia burgdorferi sensu stricto in humans from a Cuban village. Braz J Infect Dis. 2012;16:82-5 pubmed
    ..However, clinical cases have been serologically reported. Seroprevalence survey of Borrelia burgdorferi sensu stricto antibodies in humans in the country has not been conducted...
  19. Bestor A, Rego R, Tilly K, Rosa P. Competitive advantage of Borrelia burgdorferi with outer surface protein BBA03 during tick-mediated infection of the mammalian host. Infect Immun. 2012;80:3501-11 pubmed publisher
    ..conserved and differentially expressed elements of the segmented genome of the Lyme disease spirochete Borrelia burgdorferi. We previously reported that deletion of a 4...
  20. Huegli D, Moret J, Rais O, Moosmann Y, Erard P, Malinverni R, et al. Prospective study on the incidence of infection by Borrelia burgdorferi sensu lato after a tick bite in a highly endemic area of Switzerland. Ticks Tick Borne Dis. 2011;2:129-36 pubmed publisher
    ..9% of nymphs remained attached for more than 24h whereas only 38.3% of female ticks remained attached for more than 24h. We observed that 6.6% and 2.4% of participants bitten by infected and uninfected ticks, respectively, developed EM. ..
  21. Oosting M, Ter Hofstede H, Sturm P, Adema G, Kullberg B, Van der Meer J, et al. TLR1/TLR2 heterodimers play an important role in the recognition of Borrelia spirochetes. PLoS ONE. 2011;6:e25998 pubmed publisher
    ..TLR6 polymorphisms lead to a minor modified cytokine production. This study indicates a dominant role for TLR1/TLR2 heterodimers in the induction of the early inflammatory response by Borrelia spirochetes in humans. ..
  22. O Rourke M, Traweger A, Lusa L, Stupica D, Maraspin V, Barrett P, et al. Quantitative detection of Borrelia burgdorferi sensu lato in erythema migrans skin lesions using internally controlled duplex real time PCR. PLoS ONE. 2013;8:e63968 pubmed publisher
    ..This is the first quantitative PCR study of human skin biopsies predominantly infected with B. afzelii and the first study to demonstrate a clear relationship between clinical symptoms in B. afzelii-infected patients and Borrelia burden...
  23. Ouyang Z, Zhou J, Norgard M. CsrA (BB0184) is not involved in activation of the RpoN-RpoS regulatory pathway in Borrelia burgdorferi. Infect Immun. 2014;82:1511-22 pubmed publisher
    b>Borrelia burgdorferi encodes a homologue of the bacterial carbon storage regulator A (CsrA). Recently, it was reported that CsrA contributes to B...
  24. Wang X. Solution structure of decorin-binding protein A from Borrelia burgdorferi. Biochemistry. 2012;51:8353-62 pubmed publisher
    Decorin-binding protein A (DBPA) is an important lipoprotein from the bacterium Borrelia burgdorferi, the causative agent of Lyme disease...
  25. Rudenko N, Golovchenko M, Grubhoffer L, Oliver J. The rare ospC allele L of Borrelia burgdorferi sensu stricto, commonly found among samples collected in a coastal plain area of the southeastern United States, is associated with ixodes affinis ticks and local rodent hosts Peromyscus gossypinus and S. Appl Environ Microbiol. 2013;79:1403-6 pubmed publisher
    The rare ospC allele L was detected in 30% of Borrelia burgdorferi sensu stricto strains cultured from a tick species, Ixodes affinis, and two rodent host species, Peromyscus gossypinus and Sigmodon hispidus, collected in a coastal plain ..
  26. Brisson D, Zhou W, Jutras B, Casjens S, Stevenson B. Distribution of cp32 prophages among Lyme disease-causing spirochetes and natural diversity of their lipoprotein-encoding erp loci. Appl Environ Microbiol. 2013;79:4115-28 pubmed publisher
  27. Kumru O, Bunikis I, Sorokina I, Bergstrom S, Zückert W. Specificity and role of the Borrelia burgdorferi CtpA protease in outer membrane protein processing. J Bacteriol. 2011;193:5759-65 pubmed publisher
    To further characterize the function of the Borrelia burgdorferi C-terminal protease CtpA, we used site-directed mutagenesis to alter the putative CtpA cleavage site of one of its known substrates, the outer membrane (OM) porin P13...
  28. Toledo A, Coleman J, Kuhlow C, Crowley J, Benach J. The enolase of Borrelia burgdorferi is a plasminogen receptor released in outer membrane vesicles. Infect Immun. 2012;80:359-68 pubmed publisher
    The agent of Lyme disease, Borrelia burgdorferi, has a number of outer membrane proteins that are differentially regulated during its life cycle...
  29. Onder O, Humphrey P, McOmber B, Korobova F, Francella N, Greenbaum D, et al. OspC is potent plasminogen receptor on surface of Borrelia burgdorferi. J Biol Chem. 2012;287:16860-8 pubmed publisher
    ..successful infection of vertebrates by several pathogens, including the Lyme disease spirochete bacterium, Borrelia burgdorferi. B...
  30. Chan K, Awan M, Barthold S, Parveen N. Comparative molecular analyses of Borrelia burgdorferi sensu stricto strains B31 and N40D10/E9 and determination of their pathogenicity. BMC Microbiol. 2012;12:157 pubmed publisher
    ..This study further emphasizes a need to investigate multiple invasive strains of B. burgdorferi to fully appreciate the pathogenic mechanisms that contribute to Lyme disease manifestations. ..
  31. Magnarelli L, Norris S, Fikrig E. Serum antibodies to whole-cell and recombinant antigens of Borrelia burgdorferi in cottontail rabbits. J Wildl Dis. 2012;48:12-20 pubmed
    ..for total and class-specific immunoglobulin (Ig) M antibodies to whole-cell or recombinant antigens of Borrelia burgdorferi sensu stricto...
  32. Randolph S, Dobson A. Pangloss revisited: a critique of the dilution effect and the biodiversity-buffers-disease paradigm. Parasitology. 2012;139:847-63 pubmed publisher
    ..We warn against raising a straw man, an untenable argument easily dismantled and dismissed. The intrinsic value of protecting biodiversity and ecosystem function outweighs this questionable utilitarian justification...
  33. Koenigs A, Hammerschmidt C, Jutras B, Pogoryelov D, Barthel D, Skerka C, et al. BBA70 of Borrelia burgdorferi is a novel plasminogen-binding protein. J Biol Chem. 2013;288:25229-43 pubmed publisher
    The Lyme disease spirochete Borrelia burgdorferi lacks endogenous, surface-exposed proteases...
  34. Imai D, Feng S, Hodzic E, Barthold S. Dynamics of connective-tissue localization during chronic Borrelia burgdorferi infection. Lab Invest. 2013;93:900-10 pubmed publisher
    The etiologic agent of Lyme disease, Borrelia burgdorferi, localizes preferentially in the extracellular matrix during persistence. In chronically infected laboratory mice, there is a direct association between B...
  35. Russell T, Delorey M, Johnson B. Borrelia burgdorferi?BbHtrA degrades host ECM proteins and stimulates release of inflammatory cytokines in vitro. Mol Microbiol. 2013;90:241-51 pubmed publisher
    The Lyme disease spirochaete, Borrelia burgdorferi, causes damage to diverse host tissues and induces inflammation but the mechanisms of injury are poorly understood. We recently reported that a surface-exposed B...
  36. Caimano M, Kenedy M, Kairu T, Desrosiers D, Harman M, Dunham Ems S, et al. The hybrid histidine kinase Hk1 is part of a two-component system that is essential for survival of Borrelia burgdorferi in feeding Ixodes scapularis ticks. Infect Immun. 2011;79:3117-30 pubmed publisher
    Two-component systems (TCS) are principal mechanisms by which bacteria adapt to their surroundings. Borrelia burgdorferi encodes only two TCS. One is comprised of a histidine kinase, Hk2, and the response regulator Rrp2...
  37. Mathers A, Smith R, Cahill B, Lubelczyk C, Elias S, Lacombe E, et al. Strain diversity of Borrelia burgdorferi in ticks dispersed in North America by migratory birds. J Vector Ecol. 2011;36:24-9 pubmed publisher
    ..burgdorferi, including strain types associated with invasive Lyme disease. Birds and the ticks that feed on them may introduce a diversity of strains of the agent of Lyme disease to emergent areas. ..
  38. Brisson D, Baxamusa N, Schwartz I, Wormser G. Biodiversity of Borrelia burgdorferi strains in tissues of Lyme disease patients. PLoS ONE. 2011;6:e22926 pubmed publisher
    ..In this study, we compared the strain biodiversity of Borrelia burgdorferi found in tick populations with that found in skin, blood, synovial fluid or cerebrospinal fluid of Lyme ..
  39. Motaleb M, Pitzer J, Sultan S, Liu J. A novel gene inactivation system reveals altered periplasmic flagellar orientation in a Borrelia burgdorferi fliL mutant. J Bacteriol. 2011;193:3324-31 pubmed publisher
    Motility and chemotaxis are essential components of pathogenesis for many infectious bacteria, including Borrelia burgdorferi, the causative agent of Lyme disease. Motility and chemotaxis genes comprise 5 to 6% of the genome of B...
  40. Bunikis I, Kutschan Bunikis S, Bonde M, Bergstrom S. Multiplex PCR as a tool for validating plasmid content of Borrelia burgdorferi. J Microbiol Methods. 2011;86:243-7 pubmed publisher
    b>Borrelia burgdorferi has an unusual genomic structure containing 21 plasmids. These plasmids carry genes that are essential for infectivity and survival of the spirochetes in vivo...
  41. Dulebohn D, Bestor A, Rego R, Stewart P, Rosa P. Borrelia burgdorferi linear plasmid 38 is dispensable for completion of the mouse-tick infectious cycle. Infect Immun. 2011;79:3510-7 pubmed publisher
    b>Borrelia burgdorferi, the causative agent of Lyme disease, exists in a complex enzootic cycle, transiting between its vector, Ixodes ticks, and a diverse range of vertebrate hosts. B...
  42. Sarkar A, Hayes B, Dulebohn D, Rosa P. Regulation of the virulence determinant OspC by bbd18 on linear plasmid lp17 of Borrelia burgdorferi. J Bacteriol. 2011;193:5365-73 pubmed publisher
    Persistent infection of a mammalian host by Borrelia burgdorferi, the spirochete that causes Lyme disease, requires specific downregulation of an immunogenic outer surface protein, OspC...
  43. Bouchard C, Leighton P, Beauchamp G, Nguon S, Trudel L, Milord F, et al. Harvested white-tailed deer as sentinel hosts for early establishing Ixodes scapularis populations and risk from vector-borne zoonoses in southeastern Canada. J Med Entomol. 2013;50:384-93 pubmed
    ..Overall, 3, 15, and 0% of the ticks collected were polymerase chain reaction (PCR)-positive for Borrelia burgdorferi, Anaplasma phagocytophilum, and Babesia microti, respectively...
  44. Patton T, Dietrich G, Dolan M, Piesman J, Carroll J, Gilmore R. Functional analysis of the Borrelia burgdorferi bba64 gene product in murine infection via tick infestation. PLoS ONE. 2011;6:e19536 pubmed publisher
    b>Borrelia burgdorferi, the causative agent of Lyme borreliosis, is transmitted to humans from the bite of Ixodes spp. ticks. During the borrelial tick-to-mammal life cycle, B...
  45. Chan K, Casjens S, Parveen N. Detection of established virulence genes and plasmids to differentiate Borrelia burgdorferi strains. Infect Immun. 2012;80:1519-29 pubmed publisher
    b>Borrelia burgdorferi sensu stricto is the major causative agent of Lyme disease in the United States, while B. garinii and B. afzelii are more prevalent in Europe. The highly complex genome of B...
  46. Li X, McHugh G, Damle N, Sikand V, Glickstein L, Steere A. Burden and viability of Borrelia burgdorferi in skin and joints of patients with erythema migrans or lyme arthritis. Arthritis Rheum. 2011;63:2238-47 pubmed publisher
    To determine the burden and viability of Borrelia burgdorferi in the skin and joints of patients with Lyme disease...
  47. Kuo J, Nardelli D, Warner T, Callister S, Schell R. Interleukin-35 enhances Lyme arthritis in Borrelia-vaccinated and -infected mice. Clin Vaccine Immunol. 2011;18:1125-32 pubmed publisher
    ..Our data do not support a role for IL-35 as a potential therapeutic agent to reduce inflammation in Lyme arthritis. ..
  48. Love A, Schwartz I, Petzke M. Borrelia burgdorferi RNA induces type I and III interferons via Toll-like receptor 7 and contributes to production of NF-?B-dependent cytokines. Infect Immun. 2014;82:2405-16 pubmed publisher
    b>Borrelia burgdorferi elicits a potent cytokine response through activation of multiple signaling receptors on innate immune cells...
  49. Liveris D, Schwartz I, Bittker S, Cooper D, Iyer R, Cox M, et al. Improving the yield of blood cultures from patients with early Lyme disease. J Clin Microbiol. 2011;49:2166-8 pubmed publisher
    ..disease associated with erythema migrans have a positive blood culture based on microscopic detection of Borrelia burgdorferi in Barbour-Stoenner-Kelly medium after 2 to 12 weeks of incubation...
  50. Hamer S, Hickling G, Sidge J, Walker E, Tsao J. Synchronous phenology of juvenile Ixodes scapularis, vertebrate host relationships, and associated patterns of Borrelia burgdorferi ribotypes in the midwestern United States. Ticks Tick Borne Dis. 2012;3:65-74 pubmed publisher
    ..scapularis life cycle. Densities of Borrelia burgdorferi-infected, questing nymphs were comparable to those found in endemic areas elsewhere in the midwestern and ..
  51. Motaleb M, Sultan S, Miller M, Li C, Charon N. CheY3 of Borrelia burgdorferi is the key response regulator essential for chemotaxis and forms a long-lived phosphorylated intermediate. J Bacteriol. 2011;193:3332-41 pubmed publisher
    ..The genome of the Lyme disease spirochete Borrelia burgdorferi contains multiple homologues of chemotaxis genes, including three copies of cheY, referred to as cheY1, ..
  52. Antonara S, Ristow L, Coburn J. Adhesion mechanisms of Borrelia burgdorferi. Adv Exp Med Biol. 2011;715:35-49 pubmed publisher
    ..At this point, the primary focus of research in this area has been on Borrelia burgdorferi, one agent of Lyme disease, but many of the adhesins of B...
  53. Swei A, Briggs C, Lane R, Ostfeld R. Impacts of an introduced forest pathogen on the risk of Lyme disease in California. Vector Borne Zoonotic Dis. 2012;12:623-32 pubmed publisher
    ..The Lyme disease bacterium, Borrelia burgdorferi, is maintained in the far western United States by a suite of animal reservoirs including the dusky-footed ..
  54. Mannelli A, Bertolotti L, Gern L, Gray J. Ecology of Borrelia burgdorferi sensu lato in Europe: transmission dynamics in multi-host systems, influence of molecular processes and effects of climate change. FEMS Microbiol Rev. 2012;36:837-61 pubmed publisher
    The analysis of different multi-host systems suggests that even hosts that are not capable of transmitting Borrelia burgdorferi sensu lato (s.l...
  55. Hammerschmidt C, Hallström T, Skerka C, Wallich R, Stevenson B, Zipfel P, et al. Contribution of the infection-associated complement regulator-acquiring surface protein 4 (ErpC) to complement resistance of Borrelia burgdorferi. Clin Dev Immunol. 2012;2012:349657 pubmed publisher
    b>Borrelia burgdorferi evades complement-mediated killing by interacting with complement regulators through distinct complement regulator-acquiring surface proteins (CRASPs)...
  56. Casjens S, Mongodin E, Qiu W, Luft B, Schutzer S, Gilcrease E, et al. Genome stability of Lyme disease spirochetes: comparative genomics of Borrelia burgdorferi plasmids. PLoS ONE. 2012;7:e33280 pubmed publisher
    ..natural diversity, population structure and epizootic spread of the North American Lyme agent, Borrelia burgdorferi sensu stricto, a much better understanding of the natural diversity of its genome will be required...
  57. Sprong H, Hofhuis A, Gassner F, Takken W, Jacobs F, van Vliet A, et al. Circumstantial evidence for an increase in the total number and activity of Borrelia-infected Ixodes ricinus in the Netherlands. Parasit Vectors. 2012;5:294 pubmed publisher
    ..The objective of this study was to determine whether an increase in the number of questing ticks infected with B. burgdorferi sensu lato is a potential cause of the rise in Lyme disease incidence...
  58. Hawley K, Mart n Ruiz I, Iglesias Pedraz J, Berwin B, Anguita J. CD14 targets complement receptor 3 to lipid rafts during phagocytosis of Borrelia burgdorferi. Int J Biol Sci. 2013;9:803-10 pubmed publisher
    Phagocytosis of Borrelia burgdorferi, the causative agent of Lyme disease, is mediated partly by the interaction of the spirochete with Complement Receptor (CR) 3...
  59. McCall J, Baker C, Mather T, Chester S, McCall S, Irwin J, et al. The ability of a topical novel combination of fipronil, amitraz and (S)-methoprene to protect dogs from Borrelia burgdorferi and Anaplasma phagocytophilum infections transmitted by Ixodes scapularis. Vet Parasitol. 2011;179:335-42 pubmed publisher
    Healthy, purpose-bred laboratory beagle dogs that had not been exposed to ticks and were seronegative for Borrelia burgdorferi and Anaplasma phagocytophilum were randomly assigned to four groups of eight dogs each...
  60. Hoon Hanks L, Morton E, Lybecker M, Battisti J, Samuels D, Drecktrah D. Borrelia burgdorferi malQ mutants utilize disaccharides and traverse the enzootic cycle. FEMS Immunol Med Microbiol. 2012;66:157-65 pubmed publisher
    b>Borrelia burgdorferi, the causative agent of Lyme disease, cycles in nature between a vertebrate host and a tick vector. We demonstrate that B...
  61. Sze C, Smith A, Choi Y, Yang X, Pal U, Yu A, et al. Study of the response regulator Rrp1 reveals its regulatory role in chitobiose utilization and virulence of Borrelia burgdorferi. Infect Immun. 2013;81:1775-87 pubmed publisher
    Life cycle alternation between arthropod and mammals forces the Lyme disease spirochete, Borrelia burgdorferi, to adapt to different host milieus by utilizing diverse carbohydrates...
  62. Patton T, Brandt K, Nolder C, Clifton D, Carroll J, Gilmore R. Borrelia burgdorferi bba66 gene inactivation results in attenuated mouse infection by tick transmission. Infect Immun. 2013;81:2488-98 pubmed publisher
    The impact of the Borrelia burgdorferi surface-localized immunogenic lipoprotein BBA66 on vector and host infection was evaluated by inactivating the encoding gene, bba66, and characterizing the mutant phenotype throughout the natural ..
  63. Salo J, Loimaranta V, Lahdenne P, Viljanen M, Hytönen J. Decorin binding by DbpA and B of Borrelia garinii, Borrelia afzelii, and Borrelia burgdorferi sensu Stricto. J Infect Dis. 2011;204:65-73 pubmed publisher
    ..DbpA and B of Borrelia garinii, Borrelia afzelii, and Borrelia burgdorferi sensu stricto (ss) differ in their amino acid sequence, but little attention has been paid to the potential ..
  64. Scott J, Anderson J, Durden L. Widespread dispersal of Borrelia burgdorferi-infected ticks collected from songbirds across Canada. J Parasitol. 2012;98:49-59 pubmed publisher
    ..Using PCR, 52 (29.5%) of 176 Ixodes ticks tested were positive for the Lyme disease spirochete, Borrelia burgdorferi s.l. Immature blacklegged ticks, Ixodes scapularis , collected from infested songbirds had a B...
  65. Heylen D, Tijsse E, Fonville M, Matthysen E, Sprong H. Transmission dynamics of Borrelia burgdorferi s.l. in a bird tick community. Environ Microbiol. 2013;15:663-73 pubmed publisher
    We examined the Borrelia burgdorferi sensu lato circulation in a tick community consisting of three species (Ixodes ricinus, I.?frontalis, I...
  66. Haven J, Vargas L, Mongodin E, Xue V, Hernández Y, Pagan P, et al. Pervasive recombination and sympatric genome diversification driven by frequency-dependent selection in Borrelia burgdorferi, the Lyme disease bacterium. Genetics. 2011;189:951-66 pubmed publisher
    ..Natural populations of Borrelia burgdorferi, the bacterial agent of Lyme disease, consist of diverse genomic groups co-infecting single individual ..
  67. Wood E, Tamborero S, Mingarro I, Esteve Gassent M. BB0172, a Borrelia burgdorferi outer membrane protein that binds integrin ?3?1. J Bacteriol. 2013;195:3320-30 pubmed publisher
    Lyme disease is a multisystemic disorder caused by Borrelia burgdorferi infection. Upon infection, some B...
  68. Karna S, Prabhu R, Lin Y, Miller C, Seshu J. Contributions of environmental signals and conserved residues to the functions of carbon storage regulator A of Borrelia burgdorferi. Infect Immun. 2013;81:2972-85 pubmed publisher
    Carbon storage regulator A of Borrelia burgdorferi (CsrABb) contributes to vertebrate host-specific adaptation by modulating activation of the Rrp2-RpoN-RpoS pathway and is critical for infectivity...
  69. Jutras B, Chenail A, Stevenson B. Changes in bacterial growth rate govern expression of the Borrelia burgdorferi OspC and Erp infection-associated surface proteins. J Bacteriol. 2013;195:757-64 pubmed publisher
    ..can be stimulated in culture by shifting the temperature from 23°C to 34°C, leading to a hypothesis that Borrelia burgdorferi senses environmental temperature to determine its location in the tick-mammal infectious cycle...
  70. Shi C, Sahay B, Russell J, Fortner K, Hardin N, Sellati T, et al. Reduced immune response to Borrelia burgdorferi in the absence of ?? T cells. Infect Immun. 2011;79:3940-6 pubmed publisher
    ..We previously observed that ?? T cells in vitro are activated by Borrelia burgdorferi in a TLR2-dependent manner...
  71. Wang P, Lutton A, Olesik J, Vali H, Li X. A novel iron- and copper-binding protein in the Lyme disease spirochaete. Mol Microbiol. 2012;86:1441-51 pubmed publisher
    ..The Lyme disease pathogen Borrelia burgdorferi does not require iron, but its genome encodes a ferritin-like Dps (DNA-binding protein from starved ..
  72. Strle F, Ruzic Sabljic E, Logar M, Maraspin V, Lotric Furlan S, Cimperman J, et al. Comparison of erythema migrans caused by Borrelia burgdorferi and Borrelia garinii. Vector Borne Zoonotic Dis. 2011;11:1253-8 pubmed publisher
    A comparison of patients with erythema migrans due to Borrelia garinii versus Borrelia burgdorferi has not been reported. One hundred nineteen patients from New York State with erythema migrans caused by B...
  73. Sabino G, Hwang S, McAllister S, Mena P, Furie M. Interferon-? influences the composition of leukocytic infiltrates in murine lyme carditis. Am J Pathol. 2011;179:1917-28 pubmed publisher
    ..of Lyme carditis, wild-type and IFN?-deficient C57BL/6 mice were infected with the causative bacterium, Borrelia burgdorferi. Histological analysis revealed no change in the severity of carditis between wild-type and IFN?-deficient ..
  74. Tilly K, Checroun C, Rosa P. Requirements for Borrelia burgdorferi plasmid maintenance. Plasmid. 2012;68:1-12 pubmed publisher
    b>Borrelia burgdorferi has multiple linear and circular plasmids that are faithfully replicated and partitioned as the bacterium grows and divides...
  75. Charon N, Cockburn A, Li C, Liu J, Miller K, Miller M, et al. The unique paradigm of spirochete motility and chemotaxis. Annu Rev Microbiol. 2012;66:349-70 pubmed publisher
    ..Using the Lyme disease spirochete Borrelia burgdorferi (Bb) as a model system, we explore the current research on spirochete motility and chemotaxis...
  76. Durovska J, Bazovska S, Pancak J, Zaborska M, Derdakova M, Traubner P. Infection with B. burgdorferi s.l., and the CNS demyelinating disease. A case report. Neuro Endocrinol Lett. 2011;32:411-4 pubmed
    ..garinii in the liquor, indicated previous experience with the infection. Presumably, persistence of borrelia in the organism could act as one of the autoimmune process triggers, resulting in the demyelinating disease. ..
  77. Crowley J, Toledo A, LaRocca T, Coleman J, London E, Benach J. Lipid exchange between Borrelia burgdorferi and host cells. PLoS Pathog. 2013;9:e1003109 pubmed publisher
    b>Borrelia burgdorferi, the agent of Lyme disease, has cholesterol and cholesterol-glycolipids that are essential for bacterial fitness, are antigenic, and could be important in mediating interactions with cells of the eukaryotic host...
  78. Troxell B, Ye M, Yang Y, Carrasco S, Lou Y, Yang X. Manganese and zinc regulate virulence determinants in Borrelia burgdorferi. Infect Immun. 2013;81:2743-52 pubmed publisher
    b>Borrelia burgdorferi, the causative agent of Lyme disease, must adapt to two diverse niches, an arthropod vector and a mammalian host...
  79. Bourret T, Boylan J, Lawrence K, Gherardini F. Nitrosative damage to free and zinc-bound cysteine thiols underlies nitric oxide toxicity in wild-type Borrelia burgdorferi. Mol Microbiol. 2011;81:259-73 pubmed publisher
    b>Borrelia burgdorferi encounters potentially harmful reactive nitrogen species (RNS) throughout its infective cycle. In this study, diethylamine NONOate (DEA/NO) was used to characterize the lethal effects of RNS on B. burgdorferi...
  80. Hyde J, Weening E, Chang M, Trzeciakowski J, H k M, Cirillo J, et al. Bioluminescent imaging of Borrelia burgdorferi in vivo demonstrates that the fibronectin-binding protein BBK32 is required for optimal infectivity. Mol Microbiol. 2011;82:99-113 pubmed publisher
    The aetiological agent of Lyme disease, Borrelia burgdorferi, is transmitted via infected Ixodes spp. ticks. Infection, if untreated, results in dissemination to multiple tissues and significant morbidity...
  81. Strle K, Shin J, Glickstein L, Steere A. Association of a Toll-like receptor 1 polymorphism with heightened Th1 inflammatory responses and antibiotic-refractory Lyme arthritis. Arthritis Rheum. 2012;64:1497-507 pubmed publisher
    ..This study was undertaken to assess the frequency and functional outcomes of these polymorphisms in patients with Lyme disease...
  82. Lochhead R, Sonderegger F, Ma Y, Brewster J, Cornwall D, Maylor Hagen H, et al. Endothelial cells and fibroblasts amplify the arthritogenic type I IFN response in murine Lyme disease and are major sources of chemokines in Borrelia burgdorferi-infected joint tissue. J Immunol. 2012;189:2488-501 pubmed publisher
    ..been uniquely linked to the severe Lyme arthritis that develops in C3H mice infected with the spirochete Borrelia burgdorferi. In this study, the dynamic interactions that result in generation of these responses were further examined ..
  83. Norte A, Ramos J, Gern L, Nuncio M, Lopes de Carvalho I. Birds as reservoirs for Borrelia burgdorferi s.l. in Western Europe: circulation of B. turdi and other genospecies in bird-tick cycles in Portugal. Environ Microbiol. 2013;15:386-97 pubmed publisher
    Birds are important in the ecology of Borrelia burgdorferi sensu lato (s.l.) because they are important hosts for vector tick immature stages and are known reservoirs for some Borrelia genospecies...
  84. Kung F, Anguita J, Pal U. Borrelia burgdorferi and tick proteins supporting pathogen persistence in the vector. Future Microbiol. 2013;8:41-56 pubmed publisher
    b>Borrelia burgdorferi, a pathogen transmitted by Ixodes ticks, is responsible for a prevalent illness known as Lyme disease, and a vaccine for human use is unavailable. Recently, genome sequences of several B...
  85. Richer L, Brisson D, Melo R, Ostfeld R, Zeidner N, Gomes Solecki M. Reservoir targeted vaccine against Borrelia burgdorferi: a new strategy to prevent Lyme disease transmission. J Infect Dis. 2014;209:1972-80 pubmed publisher
    A high prevalence of infection with Borrelia burgdorferi in ixodid ticks is correlated with a high incidence of Lyme disease. The transmission of B...
  86. Lafrance M, Pierce J, Antonara S, Coburn J. The Borrelia burgdorferi integrin ligand P66 affects gene expression by human cells in culture. Infect Immun. 2011;79:3249-61 pubmed publisher
    b>Borrelia burgdorferi, an agent of Lyme disease, establishes persistent infection in immunocompetent animals and humans...
  87. Bouchard C, Beauchamp G, Nguon S, Trudel L, Milord F, Lindsay L, et al. Associations between Ixodes scapularis ticks and small mammal hosts in a newly endemic zone in southeastern Canada: implications for Borrelia burgdorferi transmission. Ticks Tick Borne Dis. 2011;2:183-90 pubmed publisher
    Immature Ixodes scapularis infestation and Borrelia burgdorferi infection of wild small mammals were studied from June to October in 2007 and from May to October in 2008 at 71 study sites in a zone where I...
  88. Wagner B, Freer H, Rollins A, Garcia Tapia D, Erb H, Earnhart C, et al. Antibodies to Borrelia burgdorferi OspA, OspC, OspF, and C6 antigens as markers for early and late infection in dogs. Clin Vaccine Immunol. 2012;19:527-35 pubmed publisher
    Lyme disease in the United States is caused by Borrelia burgdorferi sensu stricto, which is transmitted to mammals by infected ticks. Borrelia spirochetes differentially express immunogenic outer surface proteins (Osp)...
  89. Chaconas G. CSM murray award lecture - functional studies of the Lyme disease spirochete - from molecules to mice. Can J Microbiol. 2012;58:236-48 pubmed publisher
    ..It is caused by the spirochete Borrelia burgdorferi and related species...
  90. Rosen M, Hamer S, Gerhardt R, Jones C, Muller L, Scott M, et al. Borrelia burgdorferi not detected in widespread Ixodes scapularis (Acari: Ixodidae) collected from white-tailed deer in Tennessee. J Med Entomol. 2012;49:1473-80 pubmed
    Lyme disease (LD), caused by the bacterium Borrelia burgdorferi and transmitted in the eastern United States by blacklegged ticks, Ixodes scapularis Say, is classified as nonendemic in Tennessee and surrounding states in the Southeast...
  91. Xu Q, Shi Y, Dadhwal P, Liang F. RpoS regulates essential virulence factors remaining to be identified in Borrelia burgdorferi. PLoS ONE. 2012;7:e53212 pubmed publisher
    Since the RpoN-RpoS regulatory network was revealed in the Lyme disease spirochete Borrelia burgdorferi a decade ago, both upstream and downstream of the pathway have been intensively investigated...
  92. Tilly K, Bestor A, Rosa P. Lipoprotein succession in Borrelia burgdorferi: similar but distinct roles for OspC and VlsE at different stages of mammalian infection. Mol Microbiol. 2013;89:216-27 pubmed publisher
    b>Borrelia burgdorferi alternates between ticks and mammals, requiring variable gene expression and protein production to adapt to these diverse niches...