borrelia

Summary

Summary: A genus of gram-negative, anaerobic, helical bacteria, various species of which produce RELAPSING FEVER in humans and other animals.

Top Publications

  1. Putteet Driver A, Zhong J, Barbour A. Transgenic expression of RecA of the spirochetes Borrelia burgdorferi and Borrelia hermsii in Escherichia coli revealed differences in DNA repair and recombination phenotypes. J Bacteriol. 2004;186:2266-74 pubmed
    After unsuccessful attempts to recover a viable RecA-deficient mutant of the Lyme borreliosis agent Borrelia burgdorferi, we characterized the functional activities of RecA of B...
  2. Houhamdi L, Raoult D. Excretion of living Borrelia recurrentis in feces of infected human body lice. J Infect Dis. 2005;191:1898-906 pubmed
    Louse-borne relapsing fever (LBRF), caused by Borrelia recurrentis, is 1 of the most dangerous arthropod-borne diseases. Infection is thought to occur through louse crushing. Lice feces have not been shown to contain living borreliae...
  3. Schwan T, Raffel S, Schrumpf M, Gill J, Piesman J. Characterization of a novel relapsing fever spirochete in the midgut, coxal fluid, and salivary glands of the bat tick Carios kelleyi. Vector Borne Zoonotic Dis. 2009;9:643-7 pubmed publisher
    ..bases identified the Carios bacterium as a relapsing fever spirochete most closely related to, but distinct from, Borrelia turicatae...
  4. Chaconas G, Norris S. Peaceful coexistence amongst Borrelia plasmids: getting by with a little help from their friends?. Plasmid. 2013;70:161-7 pubmed publisher
    b>Borrelia species comprise a unique genus of bacterial pathogens. These organisms contain a segmented genome with up to two dozen plasmids ranging in size from 5 kb up to about 200 kb...
  5. Guyard C, Chester E, Raffel S, Schrumpf M, Policastro P, Porcella S, et al. Relapsing fever spirochetes contain chromosomal genes with unique direct tandemly repeated sequences. Infect Immun. 2005;73:3025-37 pubmed
    Genome sequencing of the relapsing fever spirochetes Borrelia hermsii and Borrelia turicatae identified three open reading frames (ORFs) on the chromosomes that contained internal, tandemly repeated amino acid sequences that were absent ..
  6. Bolz D, Sundsbak R, Ma Y, Akira S, Weis J, Schwan T, et al. Dual role of MyD88 in rapid clearance of relapsing fever Borrelia spp. Infect Immun. 2006;74:6750-60 pubmed
    Relapsing fever Borrelia spp. undergo antigenic variation, achieve high levels in blood, and require rapid production of immunoglobulin M (IgM) for clearance...
  7. Schulze T, Jordan R, Healy S, Roegner V, Meddis M, Jahn M, et al. Relative abundance and prevalence of selected Borrelia infections in Ixodes scapularis and Amblyomma americanum (Acari: Ixodidae) from publicly owned lands in Monmouth County, New Jersey. J Med Entomol. 2006;43:1269-75 pubmed
    ..Ixodidae) adults and nymphs to determine relative encounter frequencies and the infection prevalence of selected Borrelia spp. in their respective tick vectors...
  8. Hildebrandt A, Pauliks K, Sachse S, Straube E. Coexistence of Borrelia spp. and Babesia spp. in Ixodes ricinus ticks in Middle Germany. Vector Borne Zoonotic Dis. 2010;10:831-7 pubmed publisher
    ..were investigated by polymerase chain reaction and restriction fragment length polymorphism or sequencing for Borrelia spp. (ospA gene) and Babesia spp. (18S rRNA gene). Overall, 27.0% (270/1000) were infected with Borrelia species...
  9. Milhano N, de Carvalho I, Alves A, Arroube S, Soares J, Rodriguez P, et al. Coinfections of Rickettsia slovaca and Rickettsia helvetica with Borrelia lusitaniae in ticks collected in a Safari Park, Portugal. Ticks Tick Borne Dis. 2010;1:172-7 pubmed publisher
    b>Borrelia and Rickettsia bacteria are the most important tick-borne agents causing disease in Portugal...

More Information

Publications169 found, 100 shown here

  1. Londoño D, Bai Y, Zückert W, Gelderblom H, Cadavid D. Cardiac apoptosis in severe relapsing fever borreliosis. Infect Immun. 2005;73:7669-76 pubmed
    ..D. Thomas, R. Crawley, and A. G. Barbour, J. Exp. Med. 179:631-642, 1994). To investigate cardiac injury in borrelia carditis, we used antibody-deficient mice persistently infected with isogenic serotypes of the relapsing fever ..
  2. Maraspin V, Ruzic Sabljic E, Strle F. Lyme borreliosis and Borrelia spielmanii. Emerg Infect Dis. 2006;12:1177 pubmed
  3. Anderson J, Valenzuela J. Spit-acular entry: Borrelia gets help from a tick salivary protein to move from the mammalian host to the arthropod vector. Cell Host Microbe. 2007;2:3-4 pubmed
    ..describe how a tick salivary antioxidant neutralizes reactive oxygen species at the tick-host interface and facilitates the tick vector's acquisition of Borrelia burgdorferi bacteria from an infected mammalian host.
  4. Ramos J, Malmierca E, Reyes F, Tesfamariam A. Results of a 10-year survey of louse-borne relapsing fever in southern Ethiopia: a decline in endemicity. Ann Trop Med Parasitol. 2008;102:467-9 pubmed publisher
  5. Miller S, Porcella S, Raffel S, Schwan T, Barbour A. Large linear plasmids of Borrelia species that cause relapsing fever. J Bacteriol. 2013;195:3629-39 pubmed publisher
    b>Borrelia species of relapsing fever (RF) and Lyme disease (LD) lineages have linear chromosomes and both linear and circular plasmids...
  6. Hovis K, Freedman J, Zhang H, Forbes J, Marconi R. Identification of an antiparallel coiled-coil/loop domain required for ligand binding by the Borrelia hermsii FhbA protein: additional evidence for the role of FhbA in the host-pathogen interaction. Infect Immun. 2008;76:2113-22 pubmed publisher
    b>Borrelia hermsii, an etiological agent of tick-borne relapsing fever in North America, binds host-derived serum proteins including factor H (FH), plasminogen, and an unidentified 60-kDa protein via its FhbA protein...
  7. Miklossy J, Kis A, Radenovic A, Miller L, Forro L, Martins R, et al. Beta-amyloid deposition and Alzheimer's type changes induced by Borrelia spirochetes. Neurobiol Aging. 2006;27:228-36 pubmed
    ..occurring in AD could be induced by infectious agents, we exposed mammalian glial and neuronal cells in vitro to Borrelia burgdorferi spirochetes and to the inflammatory bacterial lipopolysaccharide (LPS)...
  8. Cadavid D, Garcia E, Gelderblom H. Coinfection with Borrelia turicatae serotype 2 prevents the severe vestibular dysfunction and earlier mortality caused by serotype 1. J Infect Dis. 2007;195:1686-93 pubmed
    Relapsing fever (RF) is a multisystemic spirochetal infection caused by different Borrelia species. Studies in our laboratory have shown that disease severity varies depending on the infecting serotype...
  9. Londoño D, Marques A, Hornung R, Cadavid D. IL-10 helps control pathogen load during high-level bacteremia. J Immunol. 2008;181:2076-83 pubmed
    ..Previously, we showed that B cell-deficient mice persistently infected with Borrelia turicatae produce high levels of IL-10 and that exogenous IL-10 reduces bacteremia...
  10. Gassner F, Verbaarschot P, Smallegange R, Spitzen J, Van Wieren S, Takken W. Variations in Ixodes ricinus density and Borrelia infections associated with cattle introduced into a woodland in The Netherlands. Appl Environ Microbiol. 2008;74:7138-44 pubmed publisher
    The effect of introduced large herbivores on the abundance of Ixodes ricinus ticks and their Borrelia infections was studied in a natural woodland in The Netherlands. Oak and pine plots, either ungrazed or grazed by cattle, were selected...
  11. Miron D, Olshinsky A, Assy N, Zuker M, Efrat M, Hussein O. Plasmodium and Borrelia co-infection. J Travel Med. 2004;11:115-6 pubmed
  12. Diza E, Papa A, Vezyri E, Tsounis S, Milonas I, Antoniadis A. Borrelia valaisiana in cerebrospinal fluid. Emerg Infect Dis. 2004;10:1692-3 pubmed
  13. Schulze T, Jordan R, Schulze C, Mixson T, Papero M. Relative encounter frequencies and prevalence of selected Borrelia, Ehrlichia, and Anaplasma infections in Amblyomma americanum and Ixodes scapularis (Acari: Ixodidae) ticks from central New Jersey. J Med Entomol. 2005;42:450-6 pubmed
    ..Polymerase chain reaction (PCR) analysis of 121 A. americanum adults yielded infection prevalences of 9.1% for Borrelia lonestari, 12.3% for Ehrlichia chaffeenensis, and 8.2% for E. ewingii, and coinfection prevalences of 4.1% for E...
  14. Halperin T, Orr N, Cohen R, Hasin T, Davidovitch N, Klement E, et al. Detection of relapsing fever in human blood samples from Israel using PCR targeting the glycerophosphodiester phosphodiesterase (GlpQ) gene. Acta Trop. 2006;98:189-95 pubmed
    Relapsing fever caused by Borrelia persica is an acute tick-borne disease infecting people in the Middle East...
  15. Skuballa J, Oehme R, Hartelt K, Petney T, Bucher T, Kimmig P, et al. European Hedgehogs as Hosts for Borrelia spp., Germany. Emerg Infect Dis. 2007;13:952-3 pubmed
  16. McCall P, Hume J, Motshegwa K, Pignatelli P, Talbert A, Kisinza W. Does tick-borne relapsing fever have an animal reservoir in East Africa?. Vector Borne Zoonotic Dis. 2007;7:659-66 pubmed
    Tick-borne relapsing fevers (TBRF) are caused by infection with Borrelia spirochetes and transmitted to humans by ticks. All except East African TBRF, caused by Borrelia duttonii, are known zoonoses...
  17. Zeidner N, Schneider B, Nuncio M, Gern L, Piesman J. Coinoculation of Borrelia spp. with tick salivary gland lysate enhances spirochete load in mice and is tick species-specific. J Parasitol. 2002;88:1276-8 pubmed
    C3H/HeN mice were inoculated with 10(6) spirochetes, either Borrelia burgdorferi strain N40 or the Portuguese strain of B. lusitaniae, PotiB2...
  18. Bhide M, Travnicek M, Levkutova M, Curlik J, Revajova V, Levkut M. Sensitivity of Borrelia genospecies to serum complement from different animals and human: a host-pathogen relationship. FEMS Immunol Med Microbiol. 2005;43:165-72 pubmed
    Different Borrelia species and serotypes were tested for their sensitivity to serum complement from various animals and human...
  19. Hasin T, Davidovitch N, Cohen R, Dagan T, Romem A, Orr N, et al. Postexposure treatment with doxycycline for the prevention of tick-borne relapsing fever. N Engl J Med. 2006;355:148-55 pubmed
    Tick-borne relapsing fever (TBRF) is an acute febrile illness. In Israel, TBRF is caused by Borrelia persica and is transmitted by Ornithodoros tholozani ticks. We examined the safety and efficacy of postexposure treatment to prevent TBRF.
  20. de Carvalho I, Fonseca J, Marques J, Ullmann A, Hojgaard A, Zeidner N, et al. Vasculitis-like syndrome associated with Borrelia lusitaniae infection. Clin Rheumatol. 2008;27:1587-91 pubmed publisher
    We report the isolation of Borrelia lusitaniae from a 13-year-old female child presenting with a vasculitis syndrome. The patient was treated with doxycycline, 100 mg bid for 20 days, and is in remission after a follow-up of 2 years...
  21. Kudryashev M, Cyrklaff M, Wallich R, Baumeister W, Frischknecht F. Distinct in situ structures of the Borrelia flagellar motor. J Struct Biol. 2010;169:54-61 pubmed publisher
    ..Here we investigated the structure of flagellar motors of Borrelia spirochetes, the causative agents of Lyme disease in humans. We revealed the structure of the motor complex at 4...
  22. Dworkin M, Schwan T, Anderson D. Tick-borne relapsing fever in North America. Med Clin North Am. 2002;86:417-33, viii-ix pubmed
    ..The illness is caused by an infection from the Borrelia species (spirochetes) that may be acquired through the bite of an infected tick (Ornithodoros species) or contact ..
  23. Goddard J, Sumner J, Nicholson W, Paddock C, Shen J, Piesman J. Survey of ticks collected in Mississippi for Rickettsia, Ehrlichia, and Borrelia species. J Vector Ecol. 2003;28:184-9 pubmed
    ..as well as from deer, dogs, and humans for spotted fever group (SFG) rickettsiae, Ehrlichia chaffeensis, and Borrelia spp. spirochetes...
  24. Dubska L, Literak I, Kocianova E, Taragelova V, Sychra O. Differential role of passerine birds in distribution of Borrelia spirochetes, based on data from ticks collected from birds during the postbreeding migration period in Central Europe. Appl Environ Microbiol. 2009;75:596-602 pubmed publisher
    b>Borrelia spirochetes in bird-feeding ticks were studied in the Czech Republic. During the postbreeding period (July to September 2005), 1,080 passerine birds infested by 2,240 Ixodes ricinus subadult ticks were examined...
  25. Dickinson G, Piccone H, Sun G, Lien E, Gatto L, Alugupalli K. Toll-like receptor 2 deficiency results in impaired antibody responses and septic shock during Borrelia hermsii infection. Infect Immun. 2010;78:4579-88 pubmed publisher
    ..antibody and pathological inflammatory responses during bacteremia, we have been studying the murine model of Borrelia hermsii infection. Toll-like receptor (TLR) signaling plays an important role in generating the rapid anti-B...
  26. Platonov A, Karan L, Kolyasnikova N, Makhneva N, Toporkova M, Maleev V, et al. Humans infected with relapsing fever spirochete Borrelia miyamotoi, Russia. Emerg Infect Dis. 2011;17:1816-23 pubmed publisher
    b>Borrelia miyamotoi is distantly related to B. burgdorferi and transmitted by the same hard-body tick species. We report 46 cases of B...
  27. Takano A, Sugimori C, Fujita H, Kadosaka T, Taylor K, Tsubota T, et al. A novel relapsing fever Borrelia sp. infects the salivary glands of the molted hard tick, Amblyomma geoemydae. Ticks Tick Borne Dis. 2012;3:259-61 pubmed publisher
    A novel relapsing fever Borrelia sp. was found in Amblyomma geoemydae in Japan. The novel Borrelia sp. was phylogenetically related to the hard (ixodid) tick-borne relapsing fever Borrelia spp. Borrelia miyamotoi and B. lonestari...
  28. Schwab J, Hammerschmidt C, Richter D, Skerka C, Matuschka F, Wallich R, et al. Borrelia valaisiana resist complement-mediated killing independently of the recruitment of immune regulators and inactivation of complement components. PLoS ONE. 2013;8:e53659 pubmed publisher
    Spirochetes belonging to the Borrelia (B.) burgdorferi sensu lato complex differ in their resistance to complement-mediated killing, particularly in regard to human serum...
  29. Eisen L, Dolan M, Piesman J, Lane R. Vector competence of Ixodes pacificus and I. spinipalpis (Acari: Ixodidae), and reservoir competence of the dusky-footed woodrat (Neotoma fuscipes) and the deer mouse (Peromyscus maniculatus), for Borrelia bissettii. J Med Entomol. 2003;40:311-20 pubmed
    ..of the dusky-footed woodrat (Neotoma fuscipes Baird) and the deer mouse (Peromyscus maniculatus [Wagner]), for Borrelia bissettii Postic, Marti Ras, Lane, Hendson, and Baranton. Both rodent species are capable reservoirs for B...
  30. Seling A, Siegel C, Fingerle V, Jutras B, Brissette C, Skerka C, et al. Functional characterization of Borrelia spielmanii outer surface proteins that interact with distinct members of the human factor H protein family and with plasminogen. Infect Immun. 2010;78:39-48 pubmed publisher
    Acquisition of complement regulator factor H (CFH) and factor H-like protein 1 (CFHL1) from human serum enables Borrelia spielmanii, one of the etiological agents of Lyme disease, to evade complement-mediated killing by the human host...
  31. Oosting M, van de Veerdonk F, Kanneganti T, Sturm P, Verschueren I, Berende A, et al. Borrelia species induce inflammasome activation and IL-17 production through a caspase-1-dependent mechanism. Eur J Immunol. 2011;41:172-81 pubmed publisher
    b>Borrelia burgdorferi spirochetes cause Lyme disease, which can result in severe clinical symptoms such as multiple joint inflammation and neurological disorders...
  32. Romualdi A, Siddiqui R, Glockner G, Lehmann R, Sühnel J. GenColors: accelerated comparative analysis and annotation of prokaryotic genomes at various stages of completeness. Bioinformatics. 2005;21:3669-71 pubmed
    ..It has been efficiently used for Borrelia garinii and is currently applied to various ongoing genome projects...
  33. Eisen L, Eisen R, Mun J, Salkeld D, Lane R. Transmission cycles of Borrelia burgdorferi and B. bissettii in relation to habitat type in northwestern California. J Vector Ecol. 2009;34:81-91 pubmed publisher
    ..was undertaken to determine which rodent species serve as primary reservoirs for the Lyme disease spirochete Borrelia burgdorferi in commonly occurring woodland types in inland areas of northwestern California, and to examine ..
  34. Norris S. Antigenic variation with a twist--the Borrelia story. Mol Microbiol. 2006;60:1319-22 pubmed
    ..most complete description to date of the vlp/vsp antigenic variation system of the relapsing fever spirochaete, Borrelia hermsii...
  35. Davis H, Vincent J, Lynch J. Tick-borne relapsing fever caused by Borrelia turicatae. Pediatr Infect Dis J. 2002;21:703-5 pubmed
    ..We report a case of Borrelia turicatae disease in a 13-year-old male youth with outdoor exposures in Texas...
  36. Gassner F, van Vliet A, Burgers S, Jacobs F, Verbaarschot P, Hovius E, et al. Geographic and temporal variations in population dynamics of Ixodes ricinus and associated Borrelia infections in The Netherlands. Vector Borne Zoonotic Dis. 2011;11:523-32 pubmed publisher
    ..risk, a longitudinal study on population dynamics of the sheep tick Ixodes ricinus and their infections with Borrelia burgdorferi sensu lato (s.l.) was undertaken at 24 sites in The Netherlands from July 2006 to December 2007...
  37. Geller J, Nazarova L, Katargina O, Järvekülg L, Fomenko N, Golovljova I. Detection and genetic characterization of relapsing fever spirochete Borrelia miyamotoi in Estonian ticks. PLoS ONE. 2012;7:e51914 pubmed publisher
    ..Estonian sequences of the European type were obtained from I. ricinus ticks only, whereas the Asian type of B. miyamotoi was shown for both tick species in the sympatric regions...
  38. Barbour A, Putteet Driver A, Bunikis J. Horizontally acquired genes for purine salvage in Borrelia spp. causing relapsing fever. Infect Immun. 2005;73:6165-8 pubmed
    Unlike Borrelia burgdorferi, the relapsing fever agent Borrelia hermsii and the related Borrelia miyamotoi had purA and purB genes of the purine salvage pathway. These were located among the rRNA genes...
  39. Crowder C, Matthews H, Schutzer S, Rounds M, Luft B, Nolte O, et al. Genotypic variation and mixtures of Lyme Borrelia in Ixodes ticks from North America and Europe. PLoS ONE. 2010;5:e10650 pubmed publisher
    Lyme disease, caused by various species of Borrelia, is transmitted by Ixodes ticks in North America and Europe. Studies have shown the genotype of Borrelia burgdorferi sensu stricto (s.s.) or the species of B. burgdorferi sensu lato (s.l...
  40. Norte A, Ramos J, Gern L, Nuncio M, Lopes de Carvalho I. Birds as reservoirs for Borrelia burgdorferi s.l. in Western Europe: circulation of B. turdi and other genospecies in bird-tick cycles in Portugal. Environ Microbiol. 2013;15:386-97 pubmed publisher
    Birds are important in the ecology of Borrelia burgdorferi sensu lato (s.l.) because they are important hosts for vector tick immature stages and are known reservoirs for some Borrelia genospecies...
  41. Lawson C, Yung B, Barbour A, Zückert W. Crystal structure of neurotropism-associated variable surface protein 1 (Vsp1) of Borrelia turicatae. J Bacteriol. 2006;188:4522-30 pubmed
    ..Two isogenic serotypes of Borrelia turicatae strain Oz1 differ in their Vsp sequences and in disease manifestations in infected mice: Vsp1 is ..
  42. Mixson T, Campbell S, Gill J, Ginsberg H, Reichard M, Schulze T, et al. Prevalence of Ehrlichia, Borrelia, and Rickettsial agents in Amblyomma americanum (Acari: Ixodidae) collected from nine states. J Med Entomol. 2006;43:1261-8 pubmed
    ..We have determined the prevalence of infection of Ehrlichia chaffeensis, E. ewingii, "Borrelia lonestari", and R. amblyommii within A. americanum ticks from 29 sites in nine states...
  43. Bárcena Uribarri I, Thein M, Sacher A, Bunikis I, Bonde M, Bergstrom S, et al. P66 porins are present in both Lyme disease and relapsing fever spirochetes: a comparison of the biophysical properties of P66 porins from six Borrelia species. Biochim Biophys Acta. 2010;1798:1197-203 pubmed publisher
    The genus Borrelia is the cause of the two human diseases: Lyme disease (LD) and relapsing fever (RF). Both LD and RF Borrelia species are obligate parasites and are dependent on nutrients provided by their hosts...
  44. Welc Faleciak R, Hildebrandt A, Sinski E. Co-infection with Borrelia species and other tick-borne pathogens in humans: two cases from Poland. Ann Agric Environ Med. 2010;17:309-13 pubmed
    Co-infection with Borrelia species and Anaplasma phagocytophilum or Babesia spp. was assessed in a retrospective study of tick-exposed individuals from southeastern Poland...
  45. Guyard C, Raffel S, Schrumpf M, Dahlstrom E, Sturdevant D, Ricklefs S, et al. Periplasmic flagellar export apparatus protein, FliH, is involved in post-transcriptional regulation of FlaB, motility and virulence of the relapsing fever spirochete Borrelia hermsii. PLoS ONE. 2013;8:e72550 pubmed publisher
    ..In the present study, we characterize a spontaneous non-motile mutant of the relapsing fever spirochete Borrelia hermsii that was straight, non-motile and deficient in periplasmic flagella...
  46. Richter D, Schlee D, Allgöwer R, Matuschka F. Relationships of a novel Lyme disease spirochete, Borrelia spielmani sp. nov., with its hosts in Central Europe. Appl Environ Microbiol. 2004;70:6414-9 pubmed
    ..Garden dormice appear to be better reservoir hosts for A14S-like spirochetes than for Borrelia afzelii, because these spirochetes are retained longer and infect ticks more readily...
  47. Saito K, Ito T, Asashima N, Ohno M, Nagai R, Fujita H, et al. Case report: Borrelia valaisiana infection in a Japanese man associated with traveling to foreign countries. Am J Trop Med Hyg. 2007;77:1124-7 pubmed
    ..He had been bitten by an Ixodes persulcatus tick in which the DNA of Borrelia valaisiana was detected. The patient's symptoms improved rapidly after treatment with minocycline...
  48. Cutler S. Relapsing fever--a forgotten disease revealed. J Appl Microbiol. 2010;108:1115-22 pubmed publisher
    ..infection, largely through improving standards of living resulting in a reduction in body lice, the vector for Borrelia recurrentis [louse-borne relapsing fever (LBRF)]...
  49. Zipfel P, Skerka C, Hellwage J, Jokiranta S, Meri S, Brade V, et al. Factor H family proteins: on complement, microbes and human diseases. Biochem Soc Trans. 2002;30:971-8 pubmed
  50. Schott M, Grosskinsky S, Brenner C, Kraiczy P, Wallich R. Molecular characterization of the interaction of Borrelia parkeri and Borrelia turicatae with human complement regulators. Infect Immun. 2010;78:2199-208 pubmed publisher
    In North America, tick-borne relapsing fever is caused by the species Borrelia hermsii, B. parkeri, and B. turicatae, which are transmitted to humans through the bite of the respective infected tick vectors...
  51. Porcella S, Raffel S, Anderson D, Gilk S, Bono J, Schrumpf M, et al. Variable tick protein in two genomic groups of the relapsing fever spirochete Borrelia hermsii in western North America. Infect Immun. 2005;73:6647-58 pubmed
    b>Borrelia hermsii is the primary cause of tick-borne relapsing fever in North America...
  52. Zhong J, Barbour A. Cross-species hybridization of a Borrelia burgdorferi DNA array reveals infection- and culture-associated genes of the unsequenced genome of the relapsing fever agent Borrelia hermsii. Mol Microbiol. 2004;51:729-48 pubmed
    The known genome sequence of Borrelia burgdorferi, an agent of Lyme borreliosis, was used to study the genetic content and gene expression in B. hermsii, another spirochete pathogen and a cause of relapsing fever...
  53. Güner E, Watanabe M, Hashimoto N, Kadosaka T, Kawamura Y, Ezaki T, et al. Borrelia turcica sp. nov., isolated from the hard tick Hyalomma aegyptium in Turkey. Int J Syst Evol Microbiol. 2004;54:1649-52 pubmed
    ..Electron microscopy revealed that strain IST7T is morphologically similar to other spirochaetes of the genus Borrelia and possesses 15 to 16 flagellae that emerge from both polar regions...
  54. Fritz C, Bronson L, Smith C, Schriefer M, Tucker J, Schwan T. Isolation and characterization of Borrelia hermsii associated with two foci of tick-borne relapsing fever in California. J Clin Microbiol. 2004;42:1123-8 pubmed
    Relapsing fever, caused by the spirochete Borrelia hermsii and transmitted by the soft tick Ornithodoros hermsi, is endemic in many rural mountainous areas of California...
  55. Lin T, Gao L, Seyfang A, Oliver J. 'Candidatus Borrelia texasensis', from the American dog tick Dermacentor variabilis. Int J Syst Evol Microbiol. 2005;55:685-93 pubmed
    TXW-1, a Borrelia strain isolated in March 1998 from an adult male Dermacentor variabilis tick feeding on a coyote from Webb county, Texas, USA, was characterized by using randomly amplified polymorphic DNA (RAPD) analysis, RFLP and ..
  56. Schwan T, Battisti J, Porcella S, Raffel S, Schrumpf M, Fischer E, et al. Glycerol-3-phosphate acquisition in spirochetes: distribution and biological activity of glycerophosphodiester phosphodiesterase (GlpQ) among Borrelia species. J Bacteriol. 2003;185:1346-56 pubmed
    ..b>Borrelia hermsii, a tick-borne relapsing-fever spirochete, contains orthologs to glpQ and glpT, genes that encode ..
  57. Alugupalli K, Gerstein R, Chen J, Szomolanyi Tsuda E, Woodland R, Leong J. The resolution of relapsing fever borreliosis requires IgM and is concurrent with expansion of B1b lymphocytes. J Immunol. 2003;170:3819-27 pubmed
    ..for the remarkably rapid clearance of individual episodes of bacteremia caused by the relapsing fever bacterium, Borrelia hermsii. SCID or Rag(-/-) mice were incapable of resolving B...
  58. Reeves W, Loftis A, Sanders F, Spinks M, Wills W, Denison A, et al. Borrelia, Coxiella, and Rickettsia in Carios capensis (Acari: Argasidae) from a brown pelican (Pelecanus occidentalis) rookery in South Carolina, USA. Exp Appl Acarol. 2006;39:321-9 pubmed
    ..South Carolina and screened 64 individual ticks, six pools of larvae, and an egg mass for DNA from Bartonella, Borrelia, Coxiella, and Rickettsia by polymerase chain reaction amplification and sequencing...
  59. Sethi N, Sondey M, Bai Y, Kim K, Cadavid D. Interaction of a neurotropic strain of Borrelia turicatae with the cerebral microcirculation system. Infect Immun. 2006;74:6408-18 pubmed
    ..next step to elucidate this phenomenon, we studied the interaction of the neurotropic Oz1 strain of the RF agent Borrelia turicatae with the cerebral microcirculation...
  60. Rudenko N, Golovchenko M, Ruzek D, Piskunova N, Mallátová N, Grubhoffer L. Molecular detection of Borrelia bissettii DNA in serum samples from patients in the Czech Republic with suspected borreliosis. FEMS Microbiol Lett. 2009;292:274-81 pubmed publisher
    ..three spirochete genospecies were considered to be the causative agents of Lyme borreliosis (LB) in Europe: Borrelia burgdorferi sensu stricto, Borrelia afzelii and Borrelia garinii...
  61. Grosskinsky S, Schott M, Brenner C, Cutler S, Kraiczy P, Zipfel P, et al. Borrelia recurrentis employs a novel multifunctional surface protein with anti-complement, anti-opsonic and invasive potential to escape innate immunity. PLoS ONE. 2009;4:e4858 pubmed publisher
    b>Borrelia recurrentis, the etiologic agent of louse-borne relapsing fever in humans, has evolved strategies, including antigenic variation, to evade immune defence, thereby causing severe diseases with high mortality rates...
  62. Tokarz R, Jain K, Bennett A, Briese T, Lipkin W. Assessment of polymicrobial infections in ticks in New York state. Vector Borne Zoonotic Dis. 2010;10:217-21 pubmed publisher
    ..We determined the prevalence of polymicrobial infection with Borrelia burgdorferi, Anaplasma phagocytophilum, Babesia microti, Borrelia miyamotoi, and Powassan virus in 286 adult ..
  63. Lopez J, McCoy B, Krajacich B, Schwan T. Acquisition and subsequent transmission of Borrelia hermsii by the soft tick Ornithodoros hermsi. J Med Entomol. 2011;48:891-5 pubmed
    Tick-borne relapsing fever is caused by spirochetes within the genus Borrelia. The hallmark of this disease is recurrent febrile episodes and high spirochete densities in mammalian blood resulting from immune evasion...
  64. Delihas N. Intergenic regions of Borrelia plasmids contain phylogenetically conserved RNA secondary structure motifs. BMC Genomics. 2009;10:101 pubmed publisher
    b>Borrelia species are unusual in that they contain a large number of linear and circular plasmids. Many of these plasmids have long intergenic regions...
  65. Lopez J, Wilder H, Hargrove R, Brooks C, Peterson K, Beare P, et al. Development of genetic system to inactivate a Borrelia turicatae surface protein selectively produced within the salivary glands of the arthropod vector. PLoS Negl Trop Dis. 2013;7:e2514 pubmed publisher
    b>Borrelia turicatae, an agent of tick-borne relapsing fever, is an example of a pathogen that can adapt to disparate conditions found when colonizing the mammalian host and arthropod vector...
  66. Gelderblom H, Londoño D, Bai Y, Cabral E, Quandt J, Hornung R, et al. High production of CXCL13 in blood and brain during persistent infection with the relapsing fever spirochete Borrelia turicatae. J Neuropathol Exp Neurol. 2007;66:208-17 pubmed
    ..To study the consequences to the brain of persistent infection with the RF spirochete Borrelia turicatae, we studied B cell (Igh6-/-) and B and T (Rag1-/-) cell-deficient mice inoculated with isogenic ..
  67. Brahim H, Perrier Gros Claude J, Postic D, Baranton G, Jambou R. Identifying relapsing fever Borrelia, Senegal. Emerg Infect Dis. 2005;11:474-5 pubmed
    We describe a nested polymerase chain reaction for the identification of Borrelia species from serum of patients with unidentified fevers...
  68. Wyplosz B, Mihaila Amrouche L, Baixench M, Bigel M, Berardi Grassias L, Fontaine C, et al. Imported tickborne relapsing fever, France. Emerg Infect Dis. 2005;11:1801-3 pubmed
  69. Herzberger P, Siegel C, Skerka C, Fingerle V, Schulte Spechtel U, Wilske B, et al. Identification and characterization of the factor H and FHL-1 binding complement regulator-acquiring surface protein 1 of the Lyme disease spirochete Borrelia spielmanii sp. nov. Int J Med Microbiol. 2009;299:141-54 pubmed publisher
    b>Borrelia spielmanii, one of the etiological agents of Lyme disease found in Europe, evades host complement-mediated killing by recruitment of the immune regulators factor H and FHL-1 from human serum...
  70. Tokarz R, Kapoor V, Samuel J, Bouyer D, Briese T, Lipkin W. Detection of tick-borne pathogens by MassTag polymerase chain reaction. Vector Borne Zoonotic Dis. 2009;9:147-52 pubmed publisher
    ..The identification of a microbe in a sample is determined by its cognate tags. Here we describe establishment and implementation of a MassTag PCR panel for surveillance of microbes implicated in tick-vectored infectious diseases. ..
  71. Sarih M, Garnier M, Boudebouch N, Bouattour A, Rihani A, Hassar M, et al. Borrelia hispanica relapsing fever, Morocco. Emerg Infect Dis. 2009;15:1626-9 pubmed publisher
    ..Molecular detection specific for the 16S rRNA gene identified Borrelia hispanica...
  72. Zückert W, Lloyd J, Stewart P, Rosa P, Barbour A. Cross-species surface display of functional spirochetal lipoproteins by recombinant Borrelia burgdorferi. Infect Immun. 2004;72:1463-9 pubmed
    Surface-exposed lipoproteins of relapsing fever (RF) and Lyme borreliosis Borrelia spirochetes mediate certain interactions of the bacteria with their arthropod and vertebrate hosts...
  73. Tordini G, Giaccherini R, Corbisiero R, Zanelli G. Relapsing fever in a traveller from Senegal: determination of Borrelia species using molecular methods. Trans R Soc Trop Med Hyg. 2006;100:992-4 pubmed
    ..Senegal in which haemoscopic and molecular investigation confirmed tick-borne relapsing fever (TBRF), suggesting Borrelia crocidurae as the causative agent...
  74. Grego E, Bertolotti L, Peletto S, Amore G, Tomassone L, Mannelli A. Borrelia lusitaniae OspA gene heterogeneity in Mediterranean basin area. J Mol Evol. 2007;65:512-8 pubmed
    In this study, Borrelia lusitaniae DNA extracted from ticks and lizards was used to amplify the outer surface protein A (OspA) gene in order to increase knowledge about sequence variability in the Mediterranean basin area, to better ..
  75. Kotloski N, Nardelli D, Peterson S, Torrealba J, Warner T, Callister S, et al. Interleukin-23 is required for development of arthritis in mice vaccinated and challenged with Borrelia species. Clin Vaccine Immunol. 2008;15:1199-207 pubmed publisher
    ..Th17) cells and their associated cytokines are involved in the development of arthritis following infection with Borrelia burgdorferi...
  76. Socolovschi C, Kernif T, Raoult D, Parola P. Borrelia, Rickettsia, and Ehrlichia species in bat ticks, France, 2010. Emerg Infect Dis. 2012;18:1966-75 pubmed publisher
    ..AvBat, was also detected in 3 ticks. Four ticks were infected with Borrelia sp...
  77. Vidal V, Cutler S, Scragg I, Wright D, Kwiatkowski D. Characterisation of silent and active genes for a variable large protein of Borrelia recurrentis. BMC Infect Dis. 2002;2:25 pubmed
    We report the characterisation of the variable large protein (vlp) gene expressed by clinical isolate A1 of Borrelia recurrentis; the agent of the life-threatening disease louse-borne relapsing fever...
  78. Bunikis J, Barbour A. Third Borrelia species in white-footed mice. Emerg Infect Dis. 2005;11:1150-1 pubmed
  79. Comstedt P, Bergstrom S, Olsen B, Garpmo U, Marjavaara L, Mejlon H, et al. Migratory passerine birds as reservoirs of Lyme borreliosis in Europe. Emerg Infect Dis. 2006;12:1087-95 pubmed
    To define the role of birds as reservoirs and disseminators of Borrelia spirochetes, we characterized tick infestation and reservoir competence of migratory passerine birds in Sweden...
  80. Lim L, Rosenbaum J. Borrelia hermsii causing relapsing Fever and uveitis. Am J Ophthalmol. 2006;142:348-9 pubmed
    To describe a case of uveitis that is associated with Borrelia hermsii relapsing fever.
  81. Gugliotta J, Goethert H, Berardi V, Telford S. Meningoencephalitis from Borrelia miyamotoi in an immunocompromised patient. N Engl J Med. 2013;368:240-5 pubmed publisher
    Ixodes ticks serve as vectors for Borrelia burgdorferi, the agent of Lyme disease. Globally, these ticks often concurrently harbor B. miyamotoi, a spirochete that is classified within the relapsing-fever group of spirochetes...
  82. Stegall Faulk T, Clark D, Wright S. Detection of Borrelia lonestari in Amblyomma americanum (Acari: Ixodidae) from Tennessee. J Med Entomol. 2003;40:100-2 pubmed
    Genetic sequences characteristic of Borrelia lonestari (Barbour et al. 1996) were detected in two pools of adult Amblyomma americanum (L.) from Tennessee, corresponding to an estimated minimum field infection rate of 8...
  83. Clark K. Borrelia species in host-seeking ticks and small mammals in northern Florida. J Clin Microbiol. 2004;42:5076-86 pubmed
    ..of this study was to improve understanding of several factors related to the ecology and environmental risk of Borrelia infection in northern Florida...
  84. Larsson C, Andersson M, Bergstrom S. Current issues in relapsing fever. Curr Opin Infect Dis. 2009;22:443-9 pubmed publisher
    ..This review focuses on recent advances in diagnostics, molecular biology and host-pathogen interactions...
  85. Barbour A, Bunikis J, Travinsky B, Hoen A, Diuk Wasser M, Fish D, et al. Niche partitioning of Borrelia burgdorferi and Borrelia miyamotoi in the same tick vector and mammalian reservoir species. Am J Trop Med Hyg. 2009;81:1120-31 pubmed publisher
    The Lyme borreliosis agent Borrelia burgdorferi and the relapsing fever group species Borrelia miyamotoi co-occur in the United States...
  86. Pettersson J, Schrumpf M, Raffel S, Porcella S, Guyard C, Lawrence K, et al. Purine salvage pathways among Borrelia species. Infect Immun. 2007;75:3877-84 pubmed
    Genome sequencing projects on two relapsing fever spirochetes, Borrelia hermsii and Borrelia turicatae, revealed differences in genes involved in purine metabolism and salvage compared to those in the Lyme disease spirochete Borrelia ..
  87. Moore V, Varela A, Yabsley M, Davidson W, Little S. Detection of Borrelia lonestari, putative agent of southern tick-associated rash illness, in white-tailed deer (Odocoileus virginianus) from the southeastern United States. J Clin Microbiol. 2003;41:424-7 pubmed
    To determine if white-tailed deer may serve as a reservoir host for Borrelia lonestari, we used a nested PCR for the Borrelia flagellin gene to evaluate blood samples collected from deer from eight southeastern states. Seven of 80 deer (8...
  88. Collares Pereira M, Couceiro S, Franca I, Kurtenbach K, Schafer S, Vitorino L, et al. First isolation of Borrelia lusitaniae from a human patient. J Clin Microbiol. 2004;42:1316-8 pubmed
    The first human isolate of Borrelia lusitaniae recovered from a Portuguese patient with suspected Lyme borreliosis is described. This isolate, from a chronic skin lesion, is also the first human isolate of Borrelia in Portugal...
  89. Jouda F, Perret J, Gern L. Ixodes ricinus density, and distribution and prevalence of Borrelia burgdorferi sensu lato infection along an altitudinal gradient. J Med Entomol. 2004;41:162-9 pubmed
    In this study, we measured the phenology of Ixodes ricinus ticks and their infection with Borrelia burgdorferi sensu lato (sl) simultaneously along an altitudinal gradient to assess the impact of climate on the phenology of ticks and on ..
  90. Meri T, Cutler S, Blom A, Meri S, Jokiranta T. Relapsing fever spirochetes Borrelia recurrentis and B. duttonii acquire complement regulators C4b-binding protein and factor H. Infect Immun. 2006;74:4157-63 pubmed
    Relapsing fever is a rapidly progressive and severe septic disease caused by certain Borrelia spirochetes. The disease is divided into two forms, i.e...
  91. Parola P, Diatta G, Socolovschi C, Mediannikov O, Tall A, Bassene H, et al. Tick-borne relapsing fever borreliosis, rural senegal. Emerg Infect Dis. 2011;17:883-5 pubmed publisher
    ..Using real-time PCR specific for the 16S rRNA Borrelia gene, we found 27 (13%) of 206 samples from febrile patients in rural Senegal to be positive, whereas thick blood ..
  92. Alugupalli K, Akira S, Lien E, Leong J. MyD88- and Bruton's tyrosine kinase-mediated signals are essential for T cell-independent pathogen-specific IgM responses. J Immunol. 2007;178:3740-9 pubmed
    ..To understand the immune mechanisms required for the rapid control of bacteremia, we studied Borrelia hermsii, a bacterial pathogen that colonizes the blood stream of humans and rodents to an extremely high density...