mycoplasma pulmonis

Summary

Summary: A species of gram-negative bacteria highly pathogenic to RATS and MICE. It is the primary cause of murine respiratory mycoplasmosis.

Top Publications

  1. Reyes L, Shelton M, Riggs M, Brown M. Rat strains differ in susceptibility to maternal and fetal infection with Mycoplasma pulmonis. Am J Reprod Immunol. 2004;51:211-9 pubmed
    Vaginally infected Sprague-Dawley (SD) rats are more susceptible to adverse pregnancy outcomes than Wistar (WIS) rats. We postulated that SD rats have enhanced hematogenous spread of Mycoplasma pulmonis to fetal tissues.
  2. Bolland J, Dybvig K. Mycoplasma pulmonis Vsa proteins and polysaccharide modulate adherence to pulmonary epithelial cells. FEMS Microbiol Lett. 2012;331:25-30 pubmed publisher
    The Mycoplasma pulmonis Vsa proteins are a family of size- and phase-variable lipoproteins that shield the mycoplasmas from complement and modulate attachment to abiotic surfaces...
  3. Aurora A, Baluk P, Zhang D, Sidhu S, Dolganov G, Basbaum C, et al. Immune complex-dependent remodeling of the airway vasculature in response to a chronic bacterial infection. J Immunol. 2005;175:6319-26 pubmed
    ..for airway remodeling that occurs in mice that are chronically infected with the respiratory pathogen Mycoplasma pulmonis. Angiogenesis, lymphangiogenesis, and epithelial remodeling were greatly reduced in mice that lacked B ..
  4. Schoeb T, McConnell E, Juliana M, Davis J, Davidson M, Lindsey J. Mycoplasma pulmonis and lymphoma in bioassays in rats. Vet Pathol. 2009;46:952-9 pubmed publisher
    ..European regulatory authorities concluded that lymphomas in the aspartame study were caused by Mycoplasma pulmonis and suggested that this also was the case for the MTBE bioassay. To assess the role of M...
  5. Fehri L, Sirand Pugnet P, Gourgues G, Jan G, Wróblewski H, Blanchard A. Resistance to antimicrobial peptides and stress response in Mycoplasma pulmonis. Antimicrob Agents Chemother. 2005;49:4154-65 pubmed
    ..After determining the activity of 10 antimicrobial peptides against Mycoplasma pulmonis, a murine respiratory pathogen, the development of resistance was investigated...
  6. Kim D, Park J, Seok S, Cho S, Baek M, Lee H, et al. Differential identification of mycoplasma pulmonis and M. arthritidis using PCR-based RFLP. Exp Anim. 2005;54:359-62 pubmed
    b>Mycoplasma pulmonis and Mycoplasma arthritidis were differentially identified using PCR-restriction fragment length polymorphism (RFLP)...
  7. French C, Lao P, Loraine A, Matthews B, Yu H, Dybvig K. Large-scale transposon mutagenesis of Mycoplasma pulmonis. Mol Microbiol. 2008;69:67-76 pubmed publisher
    ..of mycoplasmas, the insertion site of transposon Tn4001T was determined for 1700 members of a library of Mycoplasma pulmonis mutants...
  8. Henriksson G, Helgeland L, Midtvedt T, Stierna P, Brandtzaeg P. Immune response to Mycoplasma pulmonis in nasal mucosa is modulated by the normal microbiota. Am J Respir Cell Mol Biol. 2004;31:657-62 pubmed
    ..lymphocyte responses in the upper airways was studied in rat nasal mucosa after infection with the pathogen Mycoplasma pulmonis. Phenotyping was performed in situ by paired immunofluorescence staining in germ-free (GF) and conventional ..
  9. Schoeb T, McConnell E. Commentary: further comments on Mycoplasma pulmonis and lymphoma in bioassays of rats. Vet Pathol. 2011;48:420-6 pubmed publisher
    ..ether conducted with conventional (not specific pathogen free) Sprague-Dawley rats were compromised by Mycoplasma pulmonis disease...

More Information

Publications68

  1. Baluk P, Tammela T, Ator E, Lyubynska N, Achen M, Hicklin D, et al. Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation. J Clin Invest. 2005;115:247-57 pubmed
    ..We addressed these issues in mouse models of (a) chronic respiratory tract infection with Mycoplasma pulmonis and (b) adenoviral transduction of airway epithelium with VEGF family growth factors...
  2. Schoondermark van de Ven E, Philipse Bergmann I, van der Logt J. Prevalence of naturally occurring viral infections, Mycoplasma pulmonis and Clostridium piliforme in laboratory rodents in Western Europe screened from 2000 to 2003. Lab Anim. 2006;40:137-43 pubmed
    ..such as pneumonia virus of mice, reovirus type 3, Sendai virus, sialodacryoadenitis/rat coronavirus and Mycoplasma pulmonis. The introduction of new detection methods showed that mouse parvovirus and rat parvovirus, both members of ..
  3. Mahler M, Köhl W. A serological survey to evaluate contemporary prevalence of viral agents and Mycoplasma pulmonis in laboratory mice and rats in western Europe. Lab Anim (NY). 2009;38:161-5 pubmed publisher
    To evaluate current prevalence rates of 24 viruses and of the bacterium Mycoplasma pulmonis, the authors retrospectively surveyed serological data obtained from laboratory mice and rats housed in more than 100 western European ..
  4. Simmons W, Bolland J, Daubenspeck J, Dybvig K. A stochastic mechanism for biofilm formation by Mycoplasma pulmonis. J Bacteriol. 2007;189:1905-13 pubmed
    ..We examined biofilm formation by Mycoplasma pulmonis and found it to be dependent on the length of the tandem repeat region of the variable surface antigen (Vsa)..
  5. Simmons W, Dybvig K. Biofilms protect Mycoplasma pulmonis cells from lytic effects of complement and gramicidin. Infect Immun. 2007;75:3696-9 pubmed
    The length of the tandem repeat region of the Vsa protein of Mycoplasma pulmonis has previously been shown to modulate the susceptibility of mycoplasmas to killing by complement: cells that produce a short form of the Vsa protein are ..
  6. Dybvig K, Cao Z, French C, Yu H. Evidence for type III restriction and modification systems in Mycoplasma pulmonis. J Bacteriol. 2007;189:2197-202 pubmed
    b>Mycoplasma pulmonis possesses a cassette of genes that are predicted to code for type III restriction and modification (R-M) enzymes...
  7. Denison A, Clapper B, Dybvig K. Avoidance of the host immune system through phase variation in Mycoplasma pulmonis. Infect Immun. 2005;73:2033-9 pubmed
    Phase-variable lipoproteins are commonly found in Mycoplasma species. Mycoplasma pulmonis contains a family of extensively studied phase- and size-variable lipoproteins encoded by the vsa locus...
  8. Sun X, Jones H, Hodge L, Simecka J. Cytokine and chemokine transcription profile during Mycoplasma pulmonis infection in susceptible and resistant strains of mice: macrophage inflammatory protein 1beta (CCL4) and monocyte chemoattractant protein 2 (CCL8) and accumulation of CCR5+ Th ce. Infect Immun. 2006;74:5943-54 pubmed
    ..evaluated in lung tissues from both susceptible (BALB/c and C3H/HeN) and resistant (C57BL/6) mice after Mycoplasma pulmonis infection...
  9. Bakshi C, Malik M, Carrico P, Sellati T. T-bet deficiency facilitates airway colonization by Mycoplasma pulmonis in a murine model of asthma. J Immunol. 2006;177:1786-95 pubmed
    ..Using the T-bet-deficient (T-bet(-/-)) murine model of asthma and the natural murine pathogen Mycoplasma pulmonis, we provide a mechanistic explanation for this correlation...
  10. Xu X, Zhang D, Lyubynska N, Wolters P, Killeen N, Baluk P, et al. Mast cells protect mice from Mycoplasma pneumonia. Am J Respir Crit Care Med. 2006;173:219-25 pubmed
    ..Mice infected with Mycoplasma pulmonis can develop localized, life-long airway infection accompanied by persistent inflammation and remodeling.
  11. Odeh A, Simecka J. Regulatory CD4+CD25+ T Cells Dampen Inflammatory Disease in Murine Mycoplasma Pneumonia and Promote IL-17 and IFN-γ Responses. PLoS ONE. 2016;11:e0155648 pubmed publisher
    ..To examine this, BALB/c mice were depleted of CD25+ cells, and had increased disease severity due to Mycoplasma pulmonis infection...
  12. Rothenburger J, Himsworth C, Clifford C, Ellis J, Treuting P, Leighton F. Respiratory Pathology and Pathogens in Wild Urban Rats (Rattus norvegicus and Rattus rattus). Vet Pathol. 2015;52:1210-9 pubmed publisher
    ..05) with the presence of cilia-associated respiratory bacillus (CARB), Mycoplasma pulmonis, and increased body mass (odds ratio [OR] = 1.09; 95% confidence interval [CI] = 1.05-1.14 per 10 g)...
  13. Simmons W, Dybvig K. Mycoplasma biofilms ex vivo and in vivo. FEMS Microbiol Lett. 2009;295:77-81 pubmed publisher
    ..We observed the biofilms formed by the murine respiratory pathogen Mycoplasma pulmonis on the epithelium of trachea in tracheal organ culture and in experimentally infected mice and found ..
  14. Compton S, Macy J. Effect of Cage-Wash Temperature on the Removal of Infectious Agents from Caging and the Detection of Infectious Agents on the Filters of Animal Bedding-Disposal Cabinets by PCR Analysis. J Am Assoc Lab Anim Sci. 2015;54:745-55 pubmed
    ..Soiled cages from mice harboring MPV, Helicobacter spp., Mycoplasma pulmonis, Syphacia obvelata, and Myocoptes musculinus were washed at 110 or 180 °F or were not washed...
  15. Wawegama N, Markham P, Elso C, Kanci A, Marenda M, Browning G, et al. Autoimmune-Disease-Prone NOD Mice Help To Reveal a New Genetic Locus for Reducing Pulmonary Disease Caused by Mycoplasma pulmonis. Infect Immun. 2018;86: pubmed publisher
    ..Here we show that NOD mice are more susceptible than C57BL/6 (B6) mice to infection with Mycoplasma pulmonis, a natural model of pulmonary mycoplasmosis. The lungs of infected NOD mice had higher loads of M...
  16. Le C, Laidlaw G, Morehouse C, Naiman B, Brohawn P, Mustelin T, et al. Synergistic actions of blocking angiopoietin-2 and tumor necrosis factor-α in suppressing remodeling of blood vessels and lymphatics in airway inflammation. Am J Pathol. 2015;185:2949-68 pubmed publisher
    ..TNF)/TNF receptor signaling are known to contribute to these changes in airway inflammation after Mycoplasma pulmonis infection in mice...
  17. Seto S, Uenoyama A, Miyata M. Identification of a 521-kilodalton protein (Gli521) involved in force generation or force transmission for Mycoplasma mobile gliding. J Bacteriol. 2005;187:3502-10 pubmed
  18. Daubenspeck J, Bolland J, Luo W, Simmons W, Dybvig K. Identification of exopolysaccharide-deficient mutants of Mycoplasma pulmonis. Mol Microbiol. 2009;72:1235-45 pubmed publisher
    ..b>Mycoplasma pulmonis binds the lectin Griffonia simplicifolia I (GS-I), which is specific for terminal beta-linked galactose ..
  19. Okazaki T, Ni A, Baluk P, Ayeni O, Kearley J, Coyle A, et al. Capillary defects and exaggerated inflammatory response in the airways of EphA2-deficient mice. Am J Pathol. 2009;174:2388-99 pubmed publisher
    ..EphA2-deficient mice at various ages or EphA2-deficient mice whose airways were inflamed by either Mycoplasma pulmonis infection or ovalbumin sensitization and challenge...
  20. Lartigue C, Blanchard A, Renaudin J, Thiaucourt F, Sirand Pugnet P. Host specificity of mollicutes oriC plasmids: functional analysis of replication origin. Nucleic Acids Res. 2003;31:6610-8 pubmed
    ..dnaA gene and surrounding DnaA box sequences were obtained for the mollicutes Spiroplasma citri and Mycoplasma pulmonis. In order to study the specificity of these plasmids among mollicutes, a set of similar oriC plasmids was ..
  21. Bolland J, Simmons W, Daubenspeck J, Dybvig K. Mycoplasma polysaccharide protects against complement. Microbiology. 2012;158:1867-73 pubmed publisher
    ..the glycocalyx, mycoplasmal surface proteins and host complement were explored using the murine pathogen Mycoplasma pulmonis as a model...
  22. Jordan D, Daubenspeck J, Dybvig K. Rhamnose biosynthesis in mycoplasmas requires precursor glycans larger than monosaccharide. Mol Microbiol. 2013;89:918-28 pubmed publisher
    ..biosynthesis, the monosaccharide rhamnose was detected in the d configuration in Mycoplasma pneumoniae and Mycoplasma pulmonis, and in both the d and l configurations in Mycoplasma arthritidis...
  23. Simmons W, Denison A, Dybvig K. Resistance of Mycoplasma pulmonis to complement lysis is dependent on the number of Vsa tandem repeats: shield hypothesis. Infect Immun. 2004;72:6846-51 pubmed
    The Vsa proteins are associated with the virulence of the murine respiratory pathogen Mycoplasma pulmonis. The antigens consist of a conserved N-terminal region that is combined with one of several different variable C-terminal regions ..
  24. Taylor Robinson D, Furr P. Mycoplasma-enhanced priapism in mice. Int J STD AIDS. 2005;16:383-5 pubmed
    ..Of six strains of young adult male mice inoculated intravenously with Mycoplasma pulmonis, of murine origin, priapism was seen only in CBA mice, penile erections persisting in some for seven to 44 ..
  25. Hickman Davis J, Gibbs Erwin J, Lindsey J, Matalon S. Role of surfactant protein-A in nitric oxide production and mycoplasma killing in congenic C57BL/6 mice. Am J Respir Cell Mol Biol. 2004;30:319-25 pubmed
    ..B6.SP-A(-/-) mice infected with 10(6) colony-forming units (cfu) of Mycoplasma pulmonis had significantly higher bacterial lung loads than B6 mice at 72 h postinfection (p.i.)...
  26. Xu X, Greenland J, Baluk P, Adams A, Bose O, McDonald D, et al. Cathepsin L protects mice from mycoplasmal infection and is essential for airway lymphangiogenesis. Am J Respir Cell Mol Biol. 2013;49:437-44 pubmed publisher
    ..Hypothesizing that Ctsl helps combat bacterial infection, we investigated its role in Mycoplasma pulmonis-infected mice as a model of acute and chronic infectious airway inflammation...
  27. Cook A, Johnson C, Brown M. Beta 2 microglobulin and resistance to murine respiratory mycoplasmosis. Contemp Top Lab Anim Sci. 2004;43:18-24 pubmed
    b>Mycoplasma pulmonis (MP) infection causes murine respiratory mycoplasmosis (MRM) in mice...
  28. Fuxe J, Tabruyn S, Colton K, Zaid H, Adams A, Baluk P, et al. Pericyte requirement for anti-leak action of angiopoietin-1 and vascular remodeling in sustained inflammation. Am J Pathol. 2011;178:2897-909 pubmed publisher
    ..induced by bradykinin, iii) sustained inflammation after 7-day infection by the respiratory pathogen Mycoplasma pulmonis, or iv) leakage after bradykinin challenge in the presence of vascular stabilization by the angiopoietin-1 (..
  29. Fuxe J, Lashnits E, O Brien S, Baluk P, Tabruyn S, Kuhnert F, et al. Angiopoietin/Tie2 signaling transforms capillaries into venules primed for leukocyte trafficking in airway inflammation. Am J Pathol. 2010;176:2009-18 pubmed publisher
    ..In chronic airway inflammation in mice infected by the bacterium Mycoplasma pulmonis (M...
  30. Loganbill J, Wagner A, Besselsen D. Detection of Mycoplasma pulmonis by fluorogenic nuclease polymerase chain reaction analysis. Comp Med. 2005;55:419-24 pubmed
    b>Mycoplasma pulmonis induces persistent infections in laboratory mice and rats and can contaminate biological materials. We developed a fluorogenic nuclease polymerase chain reaction (fnPCR) assay to detect M. pulmonis specifically...
  31. Osawa M, Erickson H. FtsZ from divergent foreign bacteria can function for cell division in Escherichia coli. J Bacteriol. 2006;188:7132-40 pubmed
    FtsZs from Mycoplasma pulmonis (MpuFtsZ) and Bacillus subtilis (BsFtsZ) are only 46% and 53% identical in amino acid sequence to FtsZ from Escherichia coli (EcFtsZ)...
  32. Piasecki T, Chrząstek K, Kasprzykowska U. Mycoplasma pulmonis of Rodents as a Possible Human Pathogen. Vector Borne Zoonotic Dis. 2017;17:475-477 pubmed publisher
    b>Mycoplasma pulmonis is a naturally occurring respiratory pathogen in rodents. To date, this pathogen was not isolated from humans. This study aimed to evaluate the prevalence and seropositivity to M...
  33. Ferreira J, Yamaguti M, Marques L, Oliveira R, Neto R, Buzinhani M, et al. Detection of Mycoplasma pulmonis in laboratory rats and technicians. Zoonoses Public Health. 2008;55:229-34 pubmed publisher
    Five species of mycoplasma are associated with several rat diseases. Mycoplasma pulmonis is the most important and most studied, possibly causing disease in rats and undermining the validity of laboratory experiments. M...
  34. Liang C, Wu S, Huang Y, Lin Y, Chang W, Chou J, et al. Immunohistochemical diagnosis of mouse hepatitis virus and mycoplasma pulmonis infection with murine antiserum. J Comp Pathol. 2004;131:214-20 pubmed
    ..phosphatase-labelled avidin-biotin-complex (ABC-AP) method for diagnosis of mouse hepatitis virus (MHV) and Mycoplasma pulmonis infection from formalin-fixed, paraffin wax-embedded sections, murine antibody-positive serum being used as ..
  35. Mrazek J. Analysis of distribution indicates diverse functions of simple sequence repeats in Mycoplasma genomes. Mol Biol Evol. 2006;23:1370-85 pubmed
    ..Mycoplasma hyopneumoniae and Mycoplasma pulmonis feature abundant short adenine and thymine runs periodically spaced at 11 and 12 bp, respectively, which ..
  36. Woolard M, Hardy R, Simecka J. IL-4-independent pathways exacerbate methacholine-induced airway hyperreactivity during mycoplasma respiratory disease. J Allergy Clin Immunol. 2004;114:645-9 pubmed
    ..IL-4 is a key cytokine in the development of AHR and airway reconstruction in asthmatic patients and might be an important component in exacerbation of AHR during pulmonary mycoplasma infection...
  37. Shaw B, Simmons W, Dybvig K. The Vsa shield of Mycoplasma pulmonis is antiphagocytic. Infect Immun. 2012;80:704-9 pubmed publisher
    The infection of mice with Mycoplasma pulmonis is a model for studying chronic mycoplasmal respiratory disease...
  38. Celamkoti S, Kundeti S, Purkayastha A, Mazumder R, Buck C, Seto D. GeneOrder3.0: software for comparing the order of genes in pairs of small bacterial genomes. BMC Bioinformatics. 2004;5:52 pubmed
    ..It was originally developed for comparing virus, mitochondrion and chloroplast genomes. This is now extended to small bacterial genomes of sizes less than 2 Mb...
  39. Mounzer R, Svendsen O, Baluk P, Bergman C, Padera T, Wiig H, et al. Lymphotoxin-alpha contributes to lymphangiogenesis. Blood. 2010;116:2173-82 pubmed publisher
    ..Airways of LT?(-/-) mice infected with Mycoplasma pulmonis had significantly more lymphangiogenesis than wild type (WT) or LT?(-/-) mice, as did the skin draining ..
  40. Kitagawa Y, Tohya Y, Ike F, Kajita A, Park S, Ishii Y, et al. Indirect ELISA and indirect immunofluorescent antibody assay for detecting the antibody against murine norovirus S7 in mice. Exp Anim. 2010;59:47-55 pubmed
    ..We found that some serum samples were negative for antibodies to mouse hepatitis virus and Mycoplasma pulmonis but positive for antibody to MNV-S7...
  41. Sieve A, Meeks K, Bodhankar S, Lee S, Kolls J, Simecka J, et al. A novel IL-17-dependent mechanism of cross protection: respiratory infection with mycoplasma protects against a secondary listeria infection. Eur J Immunol. 2009;39:426-38 pubmed publisher
    ..Here we provide evidence that a primary infection with the chronic respiratory pathogen, Mycoplasma pulmonis, provides a novel form of cross protection against a secondary infection with Listeria monocytogenes that ..
  42. Hickman Davis J, McNicholas Bevensee C, Davis I, Ma H, Davis G, Bosworth C, et al. Reactive species mediate inhibition of alveolar type II sodium transport during mycoplasma infection. Am J Respir Crit Care Med. 2006;173:334-44 pubmed
    ..Mycoplasma pneumoniae is a significant cause of pneumonia in humans...
  43. Takahashi Omoe H, Omoe K, Matsushita S, Kobayashi H, Yamamoto K. Polymerase chain reaction with a primer pair in the 16S-23S rRNA spacer region for detection of Mycoplasma pulmonis in clinical isolates. Comp Immunol Microbiol Infect Dis. 2004;27:117-28 pubmed
    To develop a diagnostic tool to identify Mycoplasma pulmonis (M. pulmonis) in clinical isolates, we developed a polymerase chain reaction (PCR) assay using primers specific for the 16S-23S rRNA intergenic spacer region (SR) of M...
  44. Tabruyn S, Colton K, Morisada T, Fuxe J, Wiegand S, Thurston G, et al. Angiopoietin-2-driven vascular remodeling in airway inflammation. Am J Pathol. 2010;177:3233-43 pubmed publisher
    ..into venules at an early stage of the sustained inflammatory response in the airways of mice infected with Mycoplasma pulmonis. However, the precise contributions of both angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2) are not clear...
  45. Bodhankar S, Woolard M, Sun X, Simecka J. NK cells interfere with the generation of resistance against mycoplasma respiratory infection following nasal-pulmonary immunization. J Immunol. 2009;183:2622-31 pubmed publisher
    ..Thus, NK cells can influence the responses of multiple lymphocyte populations capable of mediating resistance to mycoplasma infection...
  46. ten Brinke A. Risk factors associated with irreversible airflow limitation in asthma. Curr Opin Allergy Clin Immunol. 2008;8:63-9 pubmed publisher
    ..This paper reviews recent literature on natural course, risk factors, and potential mechanisms of persistent airflow limitation in asthma...
  47. Riggs M, Maunsell F, Reyes L, Brown M. Hematogenous infection of Sprague-Dawley rats with Mycoplasma pulmonis: development of a model for maternal and fetal infection. Am J Obstet Gynecol. 2008;198:318.e1-7 pubmed
    The specific objective of this study was to conduct a dose response experiment with Mycoplasma pulmonis in Sprague-Dawley rats to develop a reproducible animal model of maternal and fetal infection that would provide a versatile ..
  48. Goto K, Yamamoto M, Asahara M, Tamura T, Matsumura M, Hayashimoto N, et al. Rapid identification of Mycoplasma pulmonis isolated from laboratory mice and rats using matrix-assisted laser desorption ionization time-of-flight mass spectrometry. J Vet Med Sci. 2012;74:1083-6 pubmed
    ..We developed the first database of MALDI-TOF MS profiles of Mycoplasma species, containing Mycoplasma pulmonis, M. arthritidis, and M...
  49. Peltier M, Richey L, Brown M. Placental lesions caused by experimental infection of Sprague-Dawley rats with Mycoplasma pulmonis. Am J Reprod Immunol. 2003;50:254-62 pubmed
    Sprague-Dawley (SD) rats infected during pregnancy with Mycoplasma pulmonis display adverse pregnancy outcomes that are similar to those observed in women with chorioamnionitis and may provide a good model system for this disease...
  50. Park H, Kang K, Dybvig K, Lee B, Jung Y, Lee I. Interaction of cationic antimicrobial peptides with Mycoplasma pulmonis. FEBS Lett. 2013;587:3321-6 pubmed publisher
    ..underlying the anti-mycoplasma activity of cationic antimicrobial peptides (AMPs) using four known AMPs and Mycoplasma pulmonis as a model mycoplasma. Scanning electron microscopy revealed that the integrity of the M...
  51. Shaw B, Daubenspeck J, Simmons W, Dybvig K. EPS-I polysaccharide protects Mycoplasma pulmonis from phagocytosis. FEMS Microbiol Lett. 2013;338:155-60 pubmed publisher
    ..The infection of mice with Mycoplasma pulmonis has been utilized in many in vivo and in vitro studies to gain a better understanding of host-pathogen ..
  52. Peltier M, Brown M. Experimental genital mycoplasmosis causes increased levels of mRNA for IL-6 and TNF-alpha in the placenta. Am J Reprod Immunol. 2005;53:189-98 pubmed
    ..Previous work in our laboratory with an animal model for genital infection with a similar organism, Mycoplasma pulmonis, revealed that widespread infection in maternal and fetal tissues can be experimentally induced with ..
  53. Yao L, Baluk P, Srinivasan R, Oliver G, McDonald D. Plasticity of button-like junctions in the endothelium of airway lymphatics in development and inflammation. Am J Pathol. 2012;180:2561-75 pubmed publisher
    ..In inflammation, zippers replaced buttons in airway lymphatics at 14 and 28 days after Mycoplasma pulmonis infection of the respiratory tract...
  54. Burton A, Kizhner O, Brown M, Peltier M. Effect of experimental genital mycoplasmosis on gene expression in the fetal brain. J Reprod Immunol. 2012;93:9-16 pubmed publisher
    ..In a preliminary experiment, rats were exposed at 14 days gestation (GD14) to Mycoplasma pulmonis or sterile broth and sacrificed at GD18...
  55. Peltier M, Barney B, Brown M. Effect of experimental genital mycoplasmosis on production of matrix metalloproteinases in membranes and amniotic fluid of Sprague-Dawley rats. Am J Reprod Immunol. 2007;57:116-21 pubmed
    ..We tested this hypothesis in a well-defined model system of genital infection with M. pulmonis, a natural reproductive pathogen of rats...
  56. Baluk P, Yao L, Feng J, Romano T, Jung S, Schreiter J, et al. TNF-alpha drives remodeling of blood vessels and lymphatics in sustained airway inflammation in mice. J Clin Invest. 2009;119:2954-64 pubmed publisher
    ..The microvasculature of the mouse trachea provides an ideal opportunity to study this process, as Mycoplasma pulmonis infection of mouse airways induces widespread and sustained vessel remodeling, including enlargement of ..
  57. Okazaki T, Ni A, Ayeni O, Baluk P, Yao L, Vossmeyer D, et al. alpha5beta1 Integrin blockade inhibits lymphangiogenesis in airway inflammation. Am J Pathol. 2009;174:2378-87 pubmed publisher
    ..acid (JSM8757), in a model of sustained airway inflammation in mice with Mycoplasma pulmonis infection, which is known to be accompanied by robust blood vessel remodeling and lymphangiogenesis...
  58. Fassi Fehri L, Wróblewski H, Blanchard A. Activities of antimicrobial peptides and synergy with enrofloxacin against Mycoplasma pulmonis. Antimicrob Agents Chemother. 2007;51:468-74 pubmed
    ..These results support the interest devoted to AMPs as a novel class of antimicrobial agents and pinpoint their ability to potentiate the activities of conventional antibiotics, such as fluoroquinolones...
  59. Xu X, Zhang D, Zhang H, Wolters P, Killeen N, Sullivan B, et al. Neutrophil histamine contributes to inflammation in mycoplasma pneumonia. J Exp Med. 2006;203:2907-17 pubmed
    ..To address the hypothesis that mycoplasma provokes histamine release, we exposed mice to Mycoplasma pulmonis, comparing responses in wild-type and mast cell-deficient KitW-sh/KitW-sh (W-sh) mice...