mycoplasma pneumoniae

Summary

Summary: Short filamentous organism of the genus Mycoplasma, which binds firmly to the cells of the respiratory epithelium. It is one of the etiologic agents of non-viral primary atypical pneumonia in man.

Top Publications

  1. Spuesens E, Hoogenboezem T, Sluijter M, Hartwig N, van Rossum A, Vink C. Macrolide resistance determination and molecular typing of Mycoplasma pneumoniae by pyrosequencing. J Microbiol Methods. 2010;82:214-22 pubmed publisher
    The first choice antibiotics for treatment of Mycoplasma pneumoniae infections are macrolides...
  2. Schmidl S, Gronau K, Pietack N, Hecker M, Becher D, Stülke J. The phosphoproteome of the minimal bacterium Mycoplasma pneumoniae: analysis of the complete known Ser/Thr kinome suggests the existence of novel kinases. Mol Cell Proteomics. 2010;9:1228-42 pubmed publisher
    b>Mycoplasma pneumoniae belongs to the Mollicutes, the group of organisms with the smallest genomes that are capable of host-independent life...
  3. Sasaki A, Ouchi K, Makata H, Hashimoto K, Matsubara T, Furukawa S. The effect of inhaled corticosteroids on Chlamydophila pneumoniae and Mycoplasma pneumoniae infection in children with bronchial asthma. J Infect Chemother. 2009;15:99-103 pubmed publisher
    ..whether inhaled corticosteroids (ICSs) increased the infectious load of Chlamydophila pneumoniae and/or Mycoplasma pneumoniae in the respiratory tracts of asthmatic children...
  4. Pereyre S, Charron A, Hidalgo Grass C, Touati A, Moses A, Nir Paz R, et al. The spread of Mycoplasma pneumoniae is polyclonal in both an endemic setting in France and in an epidemic setting in Israel. PLoS ONE. 2012;7:e38585 pubmed publisher
    b>Mycoplasma pneumoniae infections occur both endemically and epidemically, and macrolide resistance has been spreading for 10 years worldwide. A substantial increased incidence of M...
  5. Chaudhry R, Tabassum I, Kapoor L, Chhabra A, Sharma N, Broor S. A fulminant case of acute respiratory distress syndrome associated with Mycoplasma pneumoniae infection. Indian J Pathol Microbiol. 2010;53:555-7 pubmed publisher
    ..We suggest that M. pneumoniae infections should be included in the differential diagnosis of pathogens causing ARDS, establishing an early diagnosis may have important therapeutic implications. ..
  6. Kawai Y, Miyashita N, Yamaguchi T, Saitoh A, Kondoh E, Fujimoto H, et al. Clinical efficacy of macrolide antibiotics against genetically determined macrolide-resistant Mycoplasma pneumoniae pneumonia in paediatric patients. Respirology. 2012;17:354-62 pubmed publisher
    Since 2000, the prevalence of macrolide-resistant (MR) Mycoplasma pneumoniae has increased among paediatric patients in Japan. To determine the efficacy of macrolides against MR M...
  7. Hardy R, Coalson J, Peters J, Chaparro A, Techasaensiri C, Cantwell A, et al. Analysis of pulmonary inflammation and function in the mouse and baboon after exposure to Mycoplasma pneumoniae CARDS toxin. PLoS ONE. 2009;4:e7562 pubmed publisher
    b>Mycoplasma pneumoniae produces an ADP-ribosylating and vacuolating toxin known as the CARDS (Community Acquired Respiratory Distress Syndrome) toxin that has been shown to be cytotoxic to mammalian cells in tissue and organ culture...
  8. Waites K, Duffy L, Bébéar C, Matlow A, Talkington D, Kenny G, et al. Standardized methods and quality control limits for agar and broth microdilution susceptibility testing of Mycoplasma pneumoniae, Mycoplasma hominis, and Ureaplasma urealyticum. J Clin Microbiol. 2012;50:3542-7 pubmed publisher
    ..and consensus methods for the performance and quality control of antimicrobial susceptibility testing of Mycoplasma pneumoniae, Mycoplasma hominis, and Ureaplasma urealyticum using broth microdilution and agar dilution techniques...
  9. Ledford J, Lo B, Kislan M, Thomas J, Evans K, Cain D, et al. Surfactant protein-A inhibits mycoplasma-induced dendritic cell maturation through regulation of HMGB-1 cytokine activity. J Immunol. 2010;185:3884-94 pubmed publisher
    ..Recent publications have shown that SP-A binds to and is bacteriostatic for Mycoplasma pneumoniae in vitro. In vivo, SP-A aids in maintenance of airway homeostasis during M...

More Information

Publications97

  1. Sutherland E, King T, Icitovic N, Ameredes B, Bleecker E, Boushey H, et al. A trial of clarithromycin for the treatment of suboptimally controlled asthma. J Allergy Clin Immunol. 2010;126:747-53 pubmed publisher
    PCR studies have demonstrated evidence of Mycoplasma pneumoniae and Chlamydophila pneumoniae in the lower airways of patients with asthma...
  2. Bezerra P, Britto M, Correia J, Duarte M, Fonceca A, Rose K, et al. Viral and atypical bacterial detection in acute respiratory infection in children under five years. PLoS ONE. 2011;6:e18928 pubmed publisher
    ..AdV; 25%), Rhinoviruses (hRV; 19%), Bocavirus (hBoV; 19%), human Meta-pneumovirus (hMPV; 10%) and Mycoplasma pneumoniae (Mpp; 10%) were most prevalent...
  3. Zhao F, Liu G, Cao B, Wu J, Gu Y, He L, et al. Multiple-locus variable-number tandem-repeat analysis of 201 Mycoplasma pneumoniae isolates from Beijing, China, from 2008 to 2011. J Clin Microbiol. 2013;51:636-9 pubmed publisher
    A total of 201 Mycoplasma pneumoniae clinical isolates from Beijing, China, isolated from 2008 to 2011, were clustered into 16 multiple-locus variable-number tandem-repeat analysis (MLVA) types, of which 6 new MLVA types have never been ..
  4. Youn Y, Lee K, Hwang J, Rhim J, Kang J, Lee J, et al. Difference of clinical features in childhood Mycoplasma pneumoniae pneumonia. BMC Pediatr. 2010;10:48 pubmed publisher
    ..The severity of pulmonary lesions was associated with the absence of diagnostic IgM antibodies at presentation and lymphocyte count. Short-term paired IgM serologic test may be mandatory for early and definitive diagnosis of MP. ..
  5. Spuesens E, Oduber M, Hoogenboezem T, Sluijter M, Hartwig N, van Rossum A, et al. Sequence variations in RepMP2/3 and RepMP4 elements reveal intragenomic homologous DNA recombination events in Mycoplasma pneumoniae. Microbiology. 2009;155:2182-96 pubmed publisher
    The gene encoding major adhesin protein P1 of Mycoplasma pneumoniae, MPN141, contains two DNA sequence stretches, designated RepMP2/3 and RepMP4, which display variation among strains...
  6. Matsubara K, Morozumi M, Okada T, Matsushima T, Komiyama O, Shoji M, et al. A comparative clinical study of macrolide-sensitive and macrolide-resistant Mycoplasma pneumoniae infections in pediatric patients. J Infect Chemother. 2009;15:380-3 pubmed publisher
    In recent years, the increased prevalence of macrolide-resistant Mycoplasma pneumoniae (MR-M. pneumoniae) has become a significant issue in Japan. We isolated 94 strains of M...
  7. Tian X, Dong Y, Dong X, Li J, Li D, Jiang Y, et al. P1 gene of Mycoplasma pneumoniae in clinical isolates collected in Beijing in 2010 and relationship between genotyping and macrolide resistance. Chin Med J (Engl). 2013;126:3944-8 pubmed
    b>Mycoplasma pneumoniae is a common pathogen that caused community-acquired pneumonia (CAP)...
  8. Kashyap B, Kumar S, Sethi G, Das B, Saigal S. Comparison of PCR, culture & serological tests for the diagnosis of Mycoplasma pneumoniae in community-acquired lower respiratory tract infections in children. Indian J Med Res. 2008;128:134-9 pubmed
    b>Mycoplasma pneumoniae is known to be a major cause of lower respiratory tract infections in children. A specific diagnosis is important to institute the appropriate treatment. Information on diagnostic methods used for M...
  9. Varshney A, Chaudhry R, Saharan S, Kabra S, Dhawan B, Dar L, et al. Association of Mycoplasma pneumoniae and asthma among Indian children. FEMS Immunol Med Microbiol. 2009;56:25-31 pubmed publisher
    The role of Mycoplasma pneumoniae infection as a trigger for asthma exacerbations is well supported in previous studies. This study was designed to investigate the role of M...
  10. Degrange S, Cazanave C, Charron A, Renaudin H, Bebear C, Bebear C. Development of multiple-locus variable-number tandem-repeat analysis for molecular typing of Mycoplasma pneumoniae. J Clin Microbiol. 2009;47:914-23 pubmed publisher
    ..of a multilocus variable-number tandem-repeat (VNTR) analysis (MLVA) method for the molecular typing of Mycoplasma pneumoniae. The genomic content of M...
  11. She R, Thurber A, Hymas W, Stevenson J, Langer J, Litwin C, et al. Limited utility of culture for Mycoplasma pneumoniae and Chlamydophila pneumoniae for diagnosis of respiratory tract infections. J Clin Microbiol. 2010;48:3380-2 pubmed publisher
    We assessed the utility of culture for Mycoplasma pneumoniae and Chlamydophila pneumoniae to diagnose respiratory tract infections. Compared to PCR and IgM serology, culture was less sensitive and had extremely low yield...
  12. Okada T, Morozumi M, Tajima T, Hasegawa M, Sakata H, Ohnari S, et al. Rapid effectiveness of minocycline or doxycycline against macrolide-resistant Mycoplasma pneumoniae infection in a 2011 outbreak among Japanese children. Clin Infect Dis. 2012;55:1642-9 pubmed publisher
    b>Mycoplasma pneumoniae is a major pathogen causing community-acquired pneumonia in children and young adults. Outbreaks typically occur at intervals of several years...
  13. Takahashi T, Morozumi M, Okada T, Chiba N, Asami R, Murayama S, et al. Prolonged Mycoplasma pneumoniae infection in an elderly patient with community-acquired pneumonia. J Infect Chemother. 2009;15:243-7 pubmed publisher
    ..for six respiratory bacteria and 12 respiratory viruses performed on sputum obtained on admission showed Mycoplasma pneumoniae DNA, with no evidence of other pathogens. M...
  14. Peuchant O, Menard A, Renaudin H, Morozumi M, Ubukata K, Bebear C, et al. Increased macrolide resistance of Mycoplasma pneumoniae in France directly detected in clinical specimens by real-time PCR and melting curve analysis. J Antimicrob Chemother. 2009;64:52-8 pubmed publisher
    b>Mycoplasma pneumoniae is a common aetiological agent of community-acquired respiratory tract infections for which macrolides are the treatment of choice. In France, only two macrolide-resistant isolates were reported in 1999...
  15. Specjalski K, Jassem E. Chlamydophila pneumoniae, Mycoplasma pneumoniae infections, and asthma control. Allergy Asthma Proc. 2011;32:9-17 pubmed publisher
    ..The aim of this study was to evaluate the impact of Chlamydophila pneumoniae and Mycoplasma pneumoniae infections on the control and severity of asthma...
  16. Thomas C, Jacobs E, Dumke R. Characterization of pyruvate dehydrogenase subunit B and enolase as plasminogen-binding proteins in Mycoplasma pneumoniae. Microbiology. 2013;159:352-65 pubmed publisher
    The obligate pathogenic mycoplasma species Mycoplasma pneumoniae uses a limited but effective repertoire of virulence factors to infect and colonize the human respiratory tract...
  17. Waites K, Balish M, Atkinson T. New insights into the pathogenesis and detection of Mycoplasma pneumoniae infections. Future Microbiol. 2008;3:635-48 pubmed publisher
    b>Mycoplasma pneumoniae is a common cause of upper and lower respiratory tract infections in persons of all ages and may be responsible for up to 40% of community-acquired pneumonias...
  18. Dumke R, von Baum H, Lück P, Jacobs E. Occurrence of macrolide-resistant Mycoplasma pneumoniae strains in Germany. Clin Microbiol Infect. 2010;16:613-6 pubmed publisher
    In a total of 167 respiratory tract specimens from adult outpatients with confirmed Mycoplasma pneumoniae pneumonia, sampled between 2003 and 2008, and a further 99 isolates obtained from patients between 1991 and 2009 in Germany, M...
  19. Sekine H, Taguchi H, Watanabe H, Kawai S, Fujioka Y, Goto H, et al. Immunological analysis and pathological examination of gnotobiotic mice monoassociated with Mycoplasma pneumoniae. J Med Microbiol. 2009;58:697-705 pubmed publisher
    ..significance of the immune response was examined using germ-free mice either infected intranasally with Mycoplasma pneumoniae or inoculated with M. pneumoniae antigens (soluble antigen and partially purified antigen)...
  20. Lluch Senar M, Luong K, Lloréns Rico V, Delgado J, Fang G, Spittle K, et al. Comprehensive methylome characterization of Mycoplasma genitalium and Mycoplasma pneumoniae at single-base resolution. PLoS Genet. 2013;9:e1003191 pubmed publisher
    ..to determine the methylomes of two related human pathogen species, Mycoplasma genitalium G-37 and Mycoplasma pneumoniae M129, with single-base resolution...
  21. Cao B, Zhao C, Yin Y, Zhao F, Song S, Bai L, et al. High prevalence of macrolide resistance in Mycoplasma pneumoniae isolates from adult and adolescent patients with respiratory tract infection in China. Clin Infect Dis. 2010;51:189-94 pubmed publisher
    The resistance rate of 67 Mycoplasma pneumoniae isolates from 356 ambulatory adult patients with respiratory tract infection was 69% (46 of 67). All 46 macrolide-resistant strains harbored point mutations in the 23S ribosomal RNA gene...
  22. Puljiz I, Markotic A, Cvetko Krajinovic L, Guzvinec M, Polasek O, Kuzman I. Mycoplasma pneumoniae in adult community-acquired pneumonia increases matrix metalloproteinase-9 serum level and induces its gene expression in peripheral blood mononuclear cells. Med Sci Monit. 2012;18:CR500-505 pubmed
    ..The plasma level of MMP-9 correlated with leukocyte count in peripheral circulation (r=0.67, p<0.001). We conclude that M. pneumoniae in adult CAP induces activity of MMP-9 in peripheral blood circulation. ..
  23. Principi N, Esposito S. Macrolide-resistant Mycoplasma pneumoniae: its role in respiratory infection. J Antimicrob Chemother. 2013;68:506-11 pubmed publisher
    Although the clinical relevance of antibiotic treatment in influencing the natural course of Mycoplasma pneumoniae-associated respiratory diseases is questioned by some physicians, most experts suggest that antibiotics should be ..
  24. Maheshwari M, Kumar S, Sethi G, Bhalla P. Detection of Mycoplasma pneumoniae in children with lower respiratory tract infections. Trop Doct. 2011;41:40-2 pubmed publisher
    b>Mycoplasma pneumoniae is known to be a major cause of lower respiratory tract infections (LRTIs) in children. We studied 75 children who had been hospitalized for community-acquired LRTIs for the detection of M...
  25. Maia I, Nicolau J, Machado M, Maia L, Takakura I, Rocha P, et al. Prevalence of Chlamydia pneumoniae and Mycoplasma pneumoniae in different forms of coronary disease. Arq Bras Cardiol. 2009;92:405-11, 422-8, 439-45 pubmed
    ..Several infectious agents have been investigated since the association between atherosclerosis and infection was demonstrated; however, the results of these studies are contradictory...
  26. Xin D, Mi Z, Han X, Qin L, Li J, Wei T, et al. Molecular mechanisms of macrolide resistance in clinical isolates of Mycoplasma pneumoniae from China. Antimicrob Agents Chemother. 2009;53:2158-9 pubmed publisher
    Fifty clinical Mycoplasma pneumoniae strains were isolated from 370 children with respiratory tract infections. Four strains were susceptible to macrolides, while the other 46 (92%) were macrolide resistant...
  27. Schwartz S, Thurman K, Mitchell S, Wolff B, Winchell J. Genotyping of Mycoplasma pneumoniae isolates using real-time PCR and high-resolution melt analysis. Clin Microbiol Infect. 2009;15:756-62 pubmed publisher
    b>Mycoplasma pneumoniae is an important respiratory pathogen, accounting for up to 25% of community-acquired pneumonia, and is a common cause of hospitalized pneumonia in otherwise healthy adults and children...
  28. Jiang D, Nelson M, Gally F, Smith S, Wu Q, Minor M, et al. Airway epithelial NF-?B activation promotes Mycoplasma pneumoniae clearance in mice. PLoS ONE. 2012;7:e52969 pubmed publisher
    Respiratory infections including atypical bacteria Mycoplasma pneumoniae (Mp) contribute to the pathobiology of asthma and chronic obstructive pulmonary disease (COPD)...
  29. Ledford J, Goto H, Potts E, Degan S, Chu H, Voelker D, et al. SP-A preserves airway homeostasis during Mycoplasma pneumoniae infection in mice. J Immunol. 2009;182:7818-27 pubmed publisher
    ..SP-A has a bacteriostatic effect on Mycoplasma pneumoniae (Mp), which occurs by binding surface disaturated phosphatidylglycerols...
  30. Cloward J, Krause D. Mycoplasma pneumoniae J-domain protein required for terminal organelle function. Mol Microbiol. 2009;71:1296-307 pubmed publisher
    The cell wall-less prokaryote Mycoplasma pneumoniae causes tracheobronchitis and primary atypical pneumonia in humans...
  31. Hames C, Halbedel S, Hoppert M, Frey J, Stülke J. Glycerol metabolism is important for cytotoxicity of Mycoplasma pneumoniae. J Bacteriol. 2009;191:747-53 pubmed publisher
    Glycerol is one of the few carbon sources that can be utilized by Mycoplasma pneumoniae. Glycerol metabolism involves uptake by facilitated diffusion, phosphorylation, and the oxidation of glycerol 3-phosphate to dihydroxyacetone ..
  32. Krishnakumar R, Assad Garcia N, Benders G, Phan Q, Montague M, Glass J. Targeted chromosomal knockouts in Mycoplasma pneumoniae. Appl Environ Microbiol. 2010;76:5297-9 pubmed publisher
    ..Here, we describe a method for making targeted deletions in Mycoplasma pneumoniae by use of homologous recombination. In this method, M...
  33. Spuesens E, Fraaij P, Visser E, Hoogenboezem T, Hop W, van Adrichem L, et al. Carriage of Mycoplasma pneumoniae in the upper respiratory tract of symptomatic and asymptomatic children: an observational study. PLoS Med. 2013;10:e1001444 pubmed publisher
    b>Mycoplasma pneumoniae is thought to be a common cause of respiratory tract infections (RTIs) in children. The diagnosis of M...
  34. Sluijter M, Kaptein E, Spuesens E, Hoogenboezem T, Hartwig N, van Rossum A, et al. The Mycoplasma genitalium MG352-encoded protein is a Holliday junction resolvase that has a non-functional orthologue in Mycoplasma pneumoniae. Mol Microbiol. 2010;77:1261-77 pubmed publisher
    ..Here, we describe the proteins encoded by the Mycoplasma genitalium MG352 and Mycoplasma pneumoniae MPN528a genes (RecU(Mge) and RecU(Mpn) respectively), which share sequence similarity with RecU Holliday ..
  35. Sliman J, Metzgar D, Asseff D, Coon R, Faix D, Lizewski S. Outbreak of acute respiratory disease caused by Mycoplasma pneumoniae on board a deployed U.S. navy ship. J Clin Microbiol. 2009;47:4121-3 pubmed publisher
    ..S. Navy vessel. Laboratory tests showed Mycoplasma pneumoniae to be the etiological agent...
  36. Zhao F, Cao B, Li J, Song S, Tao X, Yin Y, et al. Sequence analysis of the p1 adhesin gene of Mycoplasma pneumoniae in clinical isolates collected in Beijing in 2008 to 2009. J Clin Microbiol. 2011;49:3000-3 pubmed publisher
    The p1 genes of 60 Mycoplasma pneumoniae clinical isolates were sequenced and compared to previously reported p1 gene sequences...
  37. Balasubramanian S, Kannan T, Hart P, Baseman J. Amino acid changes in elongation factor Tu of Mycoplasma pneumoniae and Mycoplasma genitalium influence fibronectin binding. Infect Immun. 2009;77:3533-41 pubmed publisher
    b>Mycoplasma pneumoniae and Mycoplasma genitalium are closely related organisms that cause distinct clinical manifestations and possess different tissue predilections despite their high degree of genome homology...
  38. Maier T, Schmidt A, Güell M, Kühner S, Gavin A, Aebersold R, et al. Quantification of mRNA and protein and integration with protein turnover in a bacterium. Mol Syst Biol. 2011;7:511 pubmed publisher
    ..data for mRNA, proteins, as well as individual protein half-lives from the genome-reduced bacterium Mycoplasma pneumoniae. We provide a fine-grained, quantitative analysis of basic intracellular processes under various external ..
  39. Miyashita N, Kawai Y, Yamaguchi T, Ouchi K, Oka M. Clinical potential of diagnostic methods for the rapid diagnosis of Mycoplasma pneumoniae pneumonia in adults. Eur J Clin Microbiol Infect Dis. 2011;30:439-46 pubmed publisher
    ..Society (JRS) scoring system (including six parameters), for the early presumptive diagnosis of Mycoplasma pneumoniae pneumonia in adults...
  40. Wang Y, Zhu Z, Church T, Lugogo N, Que L, Francisco D, et al. SHP-1 as a critical regulator of Mycoplasma pneumoniae-induced inflammation in human asthmatic airway epithelial cells. J Immunol. 2012;188:3371-81 pubmed publisher
    ..that SHP-1 function is defective in asthma, contributing to the increased inflammatory response induced by Mycoplasma pneumoniae, a pathogen known to exacerbate asthma. M...
  41. Wulff Burchfield E, Schell W, Eckhardt A, Pollack M, Hua Z, Rouse J, et al. Microfluidic platform versus conventional real-time polymerase chain reaction for the detection of Mycoplasma pneumoniae in respiratory specimens. Diagn Microbiol Infect Dis. 2010;67:22-9 pubmed publisher
    Rapid, accurate diagnosis of community-acquired pneumonia (CAP) due to Mycoplasma pneumoniae is compromised by low sensitivity of culture and serology. Polymerase chain reaction (PCR) has emerged as a sensitive method to detect M...
  42. Cunha B, Pherez F. Mycoplasma pneumoniae community-acquired pneumonia (CAP) in the elderly: Diagnostic significance of acute thrombocytosis. Heart Lung. 2009;38:444-9 pubmed publisher
    The most common cause of nonzoonotic atypical community-acquired pneumonia (CAP) is Mycoplasma pneumoniae. M. pneumoniae CAP is most common in young adults but may occur at any age. Like other atypical CAPs, M...
  43. Wodke J, Puchałka J, Lluch Senar M, Marcos J, Yus E, Godinho M, et al. Dissecting the energy metabolism in Mycoplasma pneumoniae through genome-scale metabolic modeling. Mol Syst Biol. 2013;9:653 pubmed publisher
    b>Mycoplasma pneumoniae, a threatening pathogen with a minimal genome, is a model organism for bacterial systems biology for which substantial experimental information is available...
  44. Li X, Atkinson T, Hagood J, Makris C, Duffy L, Waites K. Emerging macrolide resistance in Mycoplasma pneumoniae in children: detection and characterization of resistant isolates. Pediatr Infect Dis J. 2009;28:693-6 pubmed publisher
    Epidemiologic data from Asia have documented the rapid and extensive emergence of macrolide resistance in Mycoplasma pneumoniae. This drug resistance has also been documented in Europe and recently in the United States, but there is very ..
  45. Zhao F, Liu G, Wu J, Cao B, Tao X, He L, et al. Surveillance of macrolide-resistant Mycoplasma pneumoniae in Beijing, China, from 2008 to 2012. Antimicrob Agents Chemother. 2013;57:1521-3 pubmed publisher
    Macrolide resistance rates of Mycoplasma pneumoniae in the Beijing population were as high as 68.9%, 90.0%, 98.4%, 95.4%, and 97.0% in the years 2008 to 2012, respectively...
  46. Liu Y, Ye X, Zhang H, Xu X, Wang M. Multiclonal origin of macrolide-resistant Mycoplasma pneumoniae isolates as determined by multilocus variable-number tandem-repeat analysis. J Clin Microbiol. 2012;50:2793-5 pubmed publisher
    There was a high percentage of macrolide resistance in Mycoplasma pneumoniae clinical isolates in China. The genetic relatedness of macrolide-resistant M...
  47. Miyachi A, Miyazaki A, Shingu Y, Matsuda K, Dohi H, Nishida Y. Synthesis and absolute structures of Mycoplasma pneumoniae beta-glyceroglycolipid antigens. Carbohydr Res. 2009;344:36-43 pubmed publisher
    Just recently, a pair of beta-glycolipids was isolated from the cell membrane of Mycoplasma pneumoniae as a mixture of the two compounds...
  48. Thurman K, Walter N, Schwartz S, Mitchell S, Dillon M, Baughman A, et al. Comparison of laboratory diagnostic procedures for detection of Mycoplasma pneumoniae in community outbreaks. Clin Infect Dis. 2009;48:1244-9 pubmed publisher
    b>Mycoplasma pneumoniae continues to be a significant cause of community-acquired pneumonia (CAP). A more definitive methodology for reliable detection of M...
  49. Peters J, Singh H, Brooks E, Diaz J, Kannan T, Coalson J, et al. Persistence of community-acquired respiratory distress syndrome toxin-producing Mycoplasma pneumoniae in refractory asthma. Chest. 2011;140:401-407 pubmed publisher
    The role of Mycoplasma pneumoniae (Mp) in the initiation and persistence of asthma remains elusive...
  50. von Baum H, Welte T, Marre R, Suttorp N, Lück C, Ewig S. Mycoplasma pneumoniae pneumonia revisited within the German Competence Network for Community-acquired pneumonia (CAPNETZ). BMC Infect Dis. 2009;9:62 pubmed publisher
    ..Therefore, the relative impact of each atypical pathogen, particularly Mycoplasma pneumoniae deserves renewed attention.
  51. Bebear C, Pereyre S, Peuchant O. Mycoplasma pneumoniae: susceptibility and resistance to antibiotics. Future Microbiol. 2011;6:423-31 pubmed publisher
    b>Mycoplasma pneumoniae is a pathogenic mycoplasma responsible for respiratory tract infections in humans, which occurs worldwide in children and adults...
  52. Hirao S, Wada H, Nakagaki K, Saraya T, Kurai D, Mikura S, et al. Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone. FEMS Immunol Med Microbiol. 2011;62:182-9 pubmed publisher
    Recently, combination treatment with a macrolide and a steroid for Mycoplasma pneumoniae (Mp) pneumonia has been reported to be effective...
  53. Khan F, A yassin M. Mycoplasma pneumoniae associated with severe autoimmune hemolytic anemia: case report and literature review. Braz J Infect Dis. 2009;13:77-9 pubmed
    We report a case of severe hemolytic anemia following Mycoplasma pneumoniae infection in a 29-year-old male patient who was treated with azithromycin...
  54. Tabassum I, Chaudhry R, Chourasia B, Malhotra P. Identification of an N-terminal 27 kDa fragment of Mycoplasma pneumoniae P116 protein as specific immunogen in M. pneumoniae infections. BMC Infect Dis. 2010;10:350 pubmed publisher
    b>Mycoplasma pneumoniae is an important cause of respiratory tract infection and is increasingly being associated with other diseases such as asthma and extra-pulmonary complications...
  55. Loens K, Goossens H, Ieven M. Acute respiratory infection due to Mycoplasma pneumoniae: current status of diagnostic methods. Eur J Clin Microbiol Infect Dis. 2010;29:1055-69 pubmed publisher
    ..commercially available diagnostic tests, the reliable diagnosis of respiratory infection due to Mycoplasma pneumoniae remains difficult...
  56. Sluijter M, Spuesens E, Hartwig N, van Rossum A, Vink C. The Mycoplasma pneumoniae MPN490 and Mycoplasma genitalium MG339 genes encode reca homologs that promote homologous DNA strand exchange. Infect Immun. 2009;77:4905-11 pubmed publisher
    The P1, P40, and P90 proteins of Mycoplasma pneumoniae and the MgPa and P110 proteins of Mycoplasma genitalium are immunogenic adhesion proteins that display sequence variation...
  57. Maquelin K, Hoogenboezem T, Jachtenberg J, Dumke R, Jacobs E, Puppels G, et al. Raman spectroscopic typing reveals the presence of carotenoids in Mycoplasma pneumoniae. Microbiology. 2009;155:2068-77 pubmed publisher
    ..to evaluate whether this technology could also be applied as a tool to discriminate between isolates of Mycoplasma pneumoniae, which is generally considered to be a genetically highly uniform species...
  58. Huber B, Strozzi S, Steinlin M, Aebi C, Fluri S. Mycoplasma pneumoniae associated opsoclonus-myoclonus syndrome in three cases. Eur J Pediatr. 2010;169:441-5 pubmed publisher
    ..b>Mycoplasma pneumoniae has been implicated in a number of immune-mediated neurologic diseases [28]. However, the association of M...
  59. Liu C, Wang G, Zhang B, Xu H, Hu L, He X, et al. Mycoplasma pneumoniae pneumonia in hospitalized children diagnosed at acute stage by paired sera. Chin Med J (Engl). 2010;123:3444-50 pubmed
    b>Mycoplasma pneumoniae (M. pneumoniae) is a frequent cause of respiratory tract infections. However, there is deficient knowledge about the clinical manifestations of M. pneumoniae infection...
  60. Wang K, Chalker V, Bermingham A, Harrison T, Mant D, Harnden A. Mycoplasma pneumoniae and respiratory virus infections in children with persistent cough in England: a retrospective analysis. Pediatr Infect Dis J. 2011;30:1047-51 pubmed publisher
    ..This study estimates the prevalence of Mycoplasma pneumoniae (Mp) and assesses the prognostic value of detecting Mp and respiratory viruses in children with persistent ..
  61. Lai C, Chang L, Lin J, Chen W, Kuo L, Lin H, et al. High seroprevalence of Mycoplasma pneumoniae IgM in acute Q fever by enzyme-linked immunosorbent assay (ELISA). PLoS ONE. 2013;8:e77640 pubmed publisher
    ..However, studies of the serological status of Mycoplasma pneumoniae and Chlamydophila pneumoniae during Q fever are rare. We conducted a retrospective serological study of M...
  62. Spuesens E, van de Kreeke N, Estevão S, Hoogenboezem T, Sluijter M, Hartwig N, et al. Variation in a surface-exposed region of the Mycoplasma pneumoniae P40 protein as a consequence of homologous DNA recombination between RepMP5 elements. Microbiology. 2011;157:473-83 pubmed publisher
    b>Mycoplasma pneumoniae is a human pathogen that causes a range of respiratory tract infections. The first step in infection is adherence of the bacteria to the respiratory epithelium...
  63. Postic G, Danchin A, Mechold U. Characterization of NrnA homologs from Mycobacterium tuberculosis and Mycoplasma pneumoniae. RNA. 2012;18:155-65 pubmed publisher
    ..Here, we characterize NrnA homologs from important human pathogens, Mpn140 from Mycoplasma pneumoniae, and Rv2837c from Mycobacterium tuberculosis...
  64. Lee K, Kim K, Hong J, Kim K, Sohn M. Modulation of IL-8 boosted by Mycoplasma pneumoniae lysate in human airway epithelial cells. J Clin Immunol. 2013;33:1117-25 pubmed publisher
    b>Mycoplasma pneumoniae, a major cause of community-acquired pneumonia, has been recognized as a trigger for asthma inception and exacerbation. The epithelial cells on the respiratory tract parasitized by M...
  65. Pereyre S, Touati A, Petitjean Lecherbonnier J, Charron A, Vabret A, Bebear C. The increased incidence of Mycoplasma pneumoniae in France in 2011 was polyclonal, mainly involving M. pneumoniae type 1 strains. Clin Microbiol Infect. 2013;19:E212-7 pubmed publisher
    An increased incidence of Mycoplasma pneumoniae infections was reported in 2011 in two cities in France, Bordeaux and Caen...
  66. Zhao F, Cao B, He L, Yin Y, Tao X, Song S, et al. Evaluation of a new real-time PCR assay for detection of Mycoplasma pneumoniae in clinical specimens. Biomed Environ Sci. 2012;25:77-81 pubmed publisher
    To establish and evaluate a real-time PCR assay to detect Mycoplasma pneumoniae (M.pneumoniae) in clinical specimens.
  67. Somarajan S, Kannan T, Baseman J. Mycoplasma pneumoniae Mpn133 is a cytotoxic nuclease with a glutamic acid-, lysine- and serine-rich region essential for binding and internalization but not enzymatic activity. Cell Microbiol. 2010;12:1821-31 pubmed publisher
    We identified Mpn133 as a Ca(2+)-dependent cytotoxic nuclease of Mycoplasma pneumoniae. Flow cytometry analysis and immunofluorescence studies revealed the binding and internalization of recombinant Mpn133 (rMpn133) in human airway A549 ..
  68. Martinez M, Ruiz M, Zunino E, Luchsinger V, Avendaño L. Detection of Mycoplasma pneumoniae in adult community-acquired pneumonia by PCR and serology. J Med Microbiol. 2008;57:1491-5 pubmed publisher
    Diagnosis of pneumonia caused by Mycoplasma pneumoniae in adults is hampered by a lack of rapid and standardized tests for detection...
  69. Choi S, Lim J, Shimizu T, Kuwano K, Kim J, Kim H. Reactive oxygen species mediate Jak2/Stat3 activation and IL-8 expression in pulmonary epithelial cells stimulated with lipid-associated membrane proteins from Mycoplasma pneumoniae. Inflamm Res. 2012;61:493-501 pubmed publisher
    ..and activators of transcription3 (Stat3), and IL-8 expression in pulmonary epithelial cells stimulated with lipid-associated membrane proteins (LAMP) from Mycoplasma pneumoniae using a known antioxidant, N-acetylcysteine (NAC).
  70. Thaikoottathil J, Martin R, Zdunek J, Weinberger A, Rino J, Chu H. Cigarette smoke extract reduces VEGF in primary human airway epithelial cells. Eur Respir J. 2009;33:835-43 pubmed publisher
    ..The current authors determined the effect of cigarette smoke extract (CSE) alone and in combination with Mycoplasma pneumoniae (Mp) on VEGF production in well-differentiated primary normal human bronchial epithelial (NHBE) and small ..
  71. Martinez M, Ruiz M, Zunino E, Luchsinger V, Aguirre R, Avendaño L. Identification of P1 types and variants of Mycoplasma pneumoniae during an epidemic in Chile. J Med Microbiol. 2010;59:925-9 pubmed publisher
    ..In conclusion, during the 2005-2006 epidemic in Santiago, both types of M. pneumoniae circulated. Although the analysed area in the RepMP4 was small, we detected the existence of P1 variants in the two types of this organism...
  72. Sun H, Xue G, Yan C, Li S, Cao L, Yuan Y, et al. Multiple-locus variable-number tandem-repeat analysis of mycoplasma pneumoniae clinical specimens and proposal for amendment of MLVA nomenclature. PLoS ONE. 2013;8:e64607 pubmed publisher
    b>Mycoplasma pneumoniae is one of the major respiratory bacterial pathogens that cause pneumonia in humans. Multiple-locus variable-number tandem-repeat analysis (MLVA) is currently the most discriminative method for typing M...
  73. Touati A, Benard A, Hassen A, Bebear C, Pereyre S. Evaluation of five commercial real-time PCR assays for detection of Mycoplasma pneumoniae in respiratory tract specimens. J Clin Microbiol. 2009;47:2269-71 pubmed publisher
    The performances of five commercial TaqMan real-time PCR assays for the detection of Mycoplasma pneumoniae in respiratory tract specimens were evaluated in comparison with an in-house real-time PCR...
  74. Miyashita N, Maruyama T, Kobayashi T, Kobayashi H, Taguchi O, Kawai Y, et al. Community-acquired macrolide-resistant Mycoplasma pneumoniae pneumonia in patients more than 18 years of age. J Infect Chemother. 2011;17:114-8 pubmed publisher
    A macrolide-resistant Mycoplasma pneumoniae strain was isolated from two patients with community-acquired pneumonia...
  75. Nakane D, Adan Kubo J, Kenri T, Miyata M. Isolation and characterization of P1 adhesin, a leg protein of the gliding bacterium Mycoplasma pneumoniae. J Bacteriol. 2011;193:715-22 pubmed publisher
    b>Mycoplasma pneumoniae, a pathogen causing human pneumonia, binds to solid surfaces at its membrane protrusion and glides by a unique mechanism...
  76. Chang H, Jordan J, Krause D. Domain analysis of protein P30 in Mycoplasma pneumoniae cytadherence and gliding motility. J Bacteriol. 2011;193:1726-33 pubmed publisher
    The cell wall-less prokaryote Mycoplasma pneumoniae causes bronchitis and atypical pneumonia in humans...
  77. Chironna M, Sallustio A, Esposito S, Perulli M, Chinellato I, Di Bari C, et al. Emergence of macrolide-resistant strains during an outbreak of Mycoplasma pneumoniae infections in children. J Antimicrob Chemother. 2011;66:734-7 pubmed publisher
    b>Mycoplasma pneumoniae is a frequent cause of human lower respiratory tract infections (LRTIs) for which macrolides are the treatment of choice. The aim of this study was to determine the rate of macrolide resistance and to subtype M...
  78. Lu A, Wang L, Zhang X, Zhang M. Combined treatment for child refractory Mycoplasma pneumoniae pneumonia with ciprofloxacin and glucocorticoid. Pediatr Pulmonol. 2011;46:1093-7 pubmed publisher
    To evaluate the efficacy of combined treatment of ciprofloxacin and glucocorticoid for child refractory Mycoplasma pneumoniae (M. pneumoniae) pneumonia.
  79. Techasaensiri C, Tagliabue C, Cagle M, Iranpour P, Katz K, Kannan T, et al. Variation in colonization, ADP-ribosylating and vacuolating cytotoxin, and pulmonary disease severity among mycoplasma pneumoniae strains. Am J Respir Crit Care Med. 2010;182:797-804 pubmed publisher
    b>Mycoplasma pneumoniae was recently discovered to produce an ADP-ribosylating and vacuolating cytotoxin, designated CARDS toxin, which is hypothesized to be a primary pathogenic mechanism responsible for M...
  80. Gotoh K, Nishimura N, Ohshima Y, Arakawa Y, Hosono H, Yamamoto Y, et al. Detection of Mycoplasma pneumoniae by loop-mediated isothermal amplification (LAMP) assay and serology in pediatric community-acquired pneumonia. J Infect Chemother. 2012;18:662-7 pubmed publisher
    Rapid diagnosis of Mycoplasma pneumoniae pneumonia is required for treatment with effective antimicrobial agents without delay; however, this capacity has not yet been established in clinical practice...
  81. Kurata S, Taguchi H, Sasaki T, Fujioka Y, Kamiya S. Antimicrobial and immunomodulatory effect of clarithromycin on macrolide-resistant Mycoplasma pneumoniae. J Med Microbiol. 2010;59:693-701 pubmed publisher
    ..However, macrolide-resistant Mycoplasma pneumoniae has recently been isolated from clinical specimens in Japan...
  82. Kannan T, Musatovova O, Balasubramanian S, Cagle M, Jordan J, Krunkosky T, et al. Mycoplasma pneumoniae Community Acquired Respiratory Distress Syndrome toxin expression reveals growth phase and infection-dependent regulation. Mol Microbiol. 2010;76:1127-41 pubmed publisher
    b>Mycoplasma pneumoniae causes acute and chronic respiratory infections, including tracheobronchitis and community acquired pneumonia, and is linked to asthma and an array of extra-pulmonary disorders...
  83. Pignanelli S, Shurdhi A, Delucca F, Donati M. Simultaneous use of direct and indirect diagnostic techniques in atypical respiratory infections from Chlamydophila pneumoniae and Mycoplasma pneumoniae. J Clin Lab Anal. 2009;23:206-9 pubmed publisher
    ..using two real-time PCR methods: one assay for the single detection of Chlamydophila pneumoniae and Mycoplasma pneumoniae DNA and one commercially available real-time duplex PCR assay for the detection of C. pneumoniae and M...
  84. Linchevski I, Klement E, Klmenet E, Nir Paz R. Mycoplasma pneumoniae vaccine protective efficacy and adverse reactions--Systematic review and meta-analysis. Vaccine. 2009;27:2437-46 pubmed publisher
    b>Mycoplasma pneumoniae is a leading cause of both upper and lower respiratory infections that can lead to devastating sequela. Currently no primary prevention measures are available. During the 1960s and 1970s several inactivated M...
  85. Chen Z, Ji W, Wang Y, Yan Y, Zhu H, Shao X, et al. Epidemiology and associations with climatic conditions of Mycoplasma pneumoniae and Chlamydophila pneumoniae infections among Chinese children hospitalized with acute respiratory infections. Ital J Pediatr. 2013;39:34 pubmed publisher
    The incidence of severe acute respiratory tract infections in children caused by Mycoplasma pneumoniae (syn...
  86. Weng W, Peng S, Wang S, Chou Y, Lee W. Mycoplasma pneumoniae--associated transverse myelitis and rhabdomyolysis. Pediatr Neurol. 2009;40:128-30 pubmed publisher
    b>Mycoplasma pneumoniae is a common cause of respiratory tract infection. Extrapulmonary manifestations of M. pneumoniae infection are also common...
  87. Schmidl S, Otto A, Lluch Senar M, Pi ol J, Busse J, Becher D, et al. A trigger enzyme in Mycoplasma pneumoniae: impact of the glycerophosphodiesterase GlpQ on virulence and gene expression. PLoS Pathog. 2011;7:e1002263 pubmed publisher
    b>Mycoplasma pneumoniae is a causative agent of atypical pneumonia. The formation of hydrogen peroxide, a product of glycerol metabolism, is essential for host cell cytotoxicity...
  88. Kenri T, Horino A, Matsui M, Sasaki Y, Suzuki S, Narita M, et al. Complete genome sequence of Mycoplasma pneumoniae type 2a strain 309, isolated in Japan. J Bacteriol. 2012;194:1253-4 pubmed publisher
    b>Mycoplasma pneumoniae strain 309, a type 2a (subtype 2 variant) strain of this bacterium, has variations in the P1 protein, which is responsible for attachment of the bacterium to host cells...