mycoplasma hyopneumoniae

Summary

Summary: A species of gram-negative bacteria that causes MYCOPLASMA PNEUMONIA OF SWINE. The organism damages the CILIA in the airways of the pig, and thus compromises one of the most effective mechanical barriers against invading pathogens. The resulting weakening of the IMMUNE SYSTEM can encourage secondary infections, leading to porcine respiratory disease complex.

Top Publications

  1. Meyns T, Dewulf J, de Kruif A, Calus D, Haesebrouck F, Maes D. Comparison of transmission of Mycoplasma hyopneumoniae in vaccinated and non-vaccinated populations. Vaccine. 2006;24:7081-6 pubmed
    A transmission experiment was performed to quantify the effect of vaccination on the transmission of Mycoplasma hyopneumoniae (M. hyopneumoniae) in nursery piglets by means of an adjusted reproduction ratio (R(n))...
  2. Fano E, Pijoan C, Dee S, Deen J. Effect of Mycoplasma hyopneumoniae colonization at weaning on disease severity in growing pigs. Can J Vet Res. 2007;71:195-200 pubmed
    To determine whether Mycoplasma hyopneumoniae colonization at weaning in off-site weaning systems is associated with the severity of respiratory disease due to this agent in growing pigs, we studied 20 groups, each group representing a ..
  3. Sibila M, Calsamiglia M, Vidal D, Badiella L, Aldaz A, Jensen J. Dynamics of Mycoplasma hyopneumoniae infection in 12 farms with different production systems. Can J Vet Res. 2004;68:12-8 pubmed
    This study had 2 objectives: 1) to determine the involvement of Mycoplasma hyopneumoniae in respiratory outbreaks in herds of pigs, with the use of a nested polymerase chain reaction (nPCR) and an enzyme-linked immunosorbent assay (ELISA);..
  4. Dubosson C, Conzelmann C, Miserez R, Boerlin P, Frey J, Zimmermann W, et al. Development of two real-time PCR assays for the detection of Mycoplasma hyopneumoniae in clinical samples. Vet Microbiol. 2004;102:55-65 pubmed
    ..pneumonia (EP) in pigs two real-time polymerase chain reaction (rtPCR) assays for the detection of Mycoplasma hyopneumoniae in bronchial swabs from lung necropsies were established and validated in parallel...
  5. Sibila M, Bernal R, Torrents D, Riera P, Llopart D, Calsamiglia M, et al. Effect of sow vaccination against Mycoplasma hyopneumoniae on sow and piglet colonization and seroconversion, and pig lung lesions at slaughter. Vet Microbiol. 2008;127:165-70 pubmed
    The objectives of the present study were to compare Mycoplasma hyopneumoniae (Mh) colonization and serologic status on Mh vaccinated and non-vaccinated sows and to assess the effect of sow vaccination on colonization and serologic status ..
  6. McKelvie J, Morgan J, Nanjiani I, Sherington J, Rowan T, Sunderland S. Evaluation of tulathromycin for the treatment of pneumonia following experimental infection of swine with Mycoplasma hyopneumoniae. Vet Ther. 2005;6:197-202 pubmed
    Tulathromycin was evaluated in the treatment of pneumonia in weaned pigs inoculated intranasally with Mycoplasma hyopneumoniae. Five days postchallenge, the pigs were randomized to treatment with a single IM administration of saline, a ..
  7. Elicker S, Sipos W. The tissue compatibility of different Mycoplasma hyopneumoniae vaccines is mainly dependent upon their adjuvants. Berl Munch Tierarztl Wochenschr. 2009;122:348-53 pubmed
    Aim of this study was to investigate the tissue compatibility of three differently adjuvated Mycoplasma hyopneumoniae vaccines...
  8. Moreau I, Miller G, Bahnson P. Effects of Mycoplasma hyopneumoniae vaccine on pigs naturally infected with M. hyopneumoniae and porcine reproductive and respiratory syndrome virus. Vaccine. 2004;22:2328-33 pubmed
    The effects of a single-dose Mycoplasma hyopneumoniae vaccine was studied in growing pigs. Each of 24 vaccinated cohorts of approximately 1200 pigs reared in separate barns was matched by time, farm site, and sex with unvaccinated cohorts...
  9. Hwang M, Lim J, Yun H, Kim J, Jung B, Hsu W, et al. The effect of polyclonal antibody on intracellular calcium increase induced by Mycoplasma hyopneumoniae in porcine tracheal cells. Vet J. 2006;172:556-60 pubmed
    ..was undertaken to assess whether polyclonal convalescent and hyperimmune sera obtained from pigs inhibit Mycoplasma hyopneumoniae induced increases in intracellular calcium [Ca2+](i) in ciliated porcine tracheal cells...

More Information

Publications91

  1. Sibila M, Nofrarias M, López Soria S, Segales J, Riera P, Llopart D, et al. Exploratory field study on Mycoplasma hyopneumoniae infection in suckling pigs. Vet Microbiol. 2007;121:352-6 pubmed
    The present study focused on Mycoplasma hyopneumoniae (M. hyopneumoniae) detection by nPCR in nasal swabs of 507 suckling pigs...
  2. Nathues H, Woeste H, Doehring S, Fahrion A, Doherr M, Beilage E. Herd specific risk factors for Mycoplasma hyopneumoniae infections in suckling pigs at the age of weaning. Acta Vet Scand. 2013;55:30 pubmed publisher
    b>Mycoplasma hyopneumoniae is the etiologic agent of enzootic pneumonia mainly occurring in fattening pigs...
  3. Maglennon G, Cook B, Matthews D, Deeney A, Bosse J, Langford P, et al. Development of a self-replicating plasmid system for Mycoplasma hyopneumoniae. Vet Res. 2013;44:63 pubmed publisher
    b>Mycoplasma hyopneumoniae is a prevalent swine respiratory pathogen that is a major cause of economic loss to pig producers...
  4. Minion F, Lefkowitz E, Madsen M, Cleary B, Swartzell S, Mahairas G. The genome sequence of Mycoplasma hyopneumoniae strain 232, the agent of swine mycoplasmosis. J Bacteriol. 2004;186:7123-33 pubmed
    We present the complete genome sequence of Mycoplasma hyopneumoniae, an important member of the porcine respiratory disease complex. The genome is composed of 892,758 bp and has an average G+C content of 28.6 mol%...
  5. Damte D, Lee S, Hwang M, Gebru E, Choi M, Lee J, et al. Inflammatory responses to Mycoplasma hyopneumoniae in murine alveolar macrophage cell lines. N Z Vet J. 2011;59:185-90 pubmed publisher
    To investigate the mechanism by which Mycoplasma hyopneumoniae induces inflammatory responses in murine alveolar macrophage (MH-S) cells. A pathogenic strain of M...
  6. Dee S, Otake S, Deen J. Use of a production region model to assess the efficacy of various air filtration systems for preventing airborne transmission of porcine reproductive and respiratory syndrome virus and Mycoplasma hyopneumoniae: results from a 2-year study. Virus Res. 2010;154:177-84 pubmed publisher
    Porcine reproductive and respiratory syndrome virus (PRRSV) and Mycoplasma hyopneumoniae (M hyo) are economically significant pathogens of pigs that can be spread between herds via the airborne route...
  7. Deblanc C, Gorin S, Queguiner S, Gautier Bouchardon A, Ferre S, Amenna N, et al. Pre-infection of pigs with Mycoplasma hyopneumoniae modifies outcomes of infection with European swine influenza virus of H1N1, but not H1N2, subtype. Vet Microbiol. 2012;157:96-105 pubmed publisher
    Swine influenza virus (SIV) and Mycoplasma hyopneumoniae (Mhp) are widespread in farms and are major pathogens involved in the porcine respiratory disease complex (PRDC)...
  8. Meyns T, Maes D, Dewulf J, Vicca J, Haesebrouck F, de Kruif A. Quantification of the spread of Mycoplasma hyopneumoniae in nursery pigs using transmission experiments. Prev Vet Med. 2004;66:265-75 pubmed
    b>Mycoplasma hyopneumoniae (M. hyopneumoniae) is present in almost all swine herds worldwide, but transmission of the pathogen through herds is not yet fully clarified...
  9. Thacker E. Diagnosis of Mycoplasma hyopneumoniae. Anim Health Res Rev. 2004;5:317-20 pubmed
    b>Mycoplasma hyopneumoniae, the cause of enzootic pneumonia, remains an important pathogen in the swine industry...
  10. Villarreal I, Vranckx K, Calus D, Pasmans F, Haesebrouck F, Maes D. Effect of challenge of pigs previously immunised with inactivated vaccines containing homologous and heterologous Mycoplasma hyopneumoniae strains. BMC Vet Res. 2012;8:2 pubmed publisher
    b>Mycoplasma hyopneumoniae is the primary cause of enzootic pneumonia in pigs. Although vaccination is an important control tool, the results observed under field conditions are variable...
  11. Seymour L, Jenkins C, Deutscher A, Raymond B, Padula M, Tacchi J, et al. Mhp182 (P102) binds fibronectin and contributes to the recruitment of plasmin(ogen) to the Mycoplasma hyopneumoniae cell surface. Cell Microbiol. 2012;14:81-94 pubmed publisher
    b>Mycoplasma hyopneumoniae is a major, economically damaging respiratory pathogen. Although M...
  12. Redondo E, Masot A, Fernandez A, Gazquez A. Histopathological and immunohistochemical findings in the lungs of pigs infected experimentally with Mycoplasma hyopneumoniae. J Comp Pathol. 2009;140:260-70 pubmed publisher
    Pigs were infected intranasally with Mycoplasma hyopneumoniae and killed at intervals ranging from 7 to 35 days post-infection (dpi)...
  13. Otake S, Dee S, CORZO C, Oliveira S, Deen J. Long-distance airborne transport of infectious PRRSV and Mycoplasma hyopneumoniae from a swine population infected with multiple viral variants. Vet Microbiol. 2010;145:198-208 pubmed publisher
    Airborne transport of porcine reproductive and respiratory syndrome virus (PRRSV) and Mycoplasma hyopneumoniae (M hyo) has been reported out to 4.7 km...
  14. Conceição F, Moreira A, Dellagostin O. A recombinant chimera composed of R1 repeat region of Mycoplasma hyopneumoniae P97 adhesin with Escherichia coli heat-labile enterotoxin B subunit elicits immune response in mice. Vaccine. 2006;24:5734-43 pubmed
    Swine mycoplasmal pneumonia (SMP), caused by fastidious bacterium Mycoplasma hyopneumoniae, is the most important respiratory disease in swine breeding...
  15. Krakowka S, Ellis J, McNeilly F, Waldner C, Rings D, Allan G. Mycoplasma hyopneumoniae bacterins and porcine circovirus type 2 (PCV2) infection: induction of postweaning multisystemic wasting syndrome (PMWS) in the gnotobiotic swine model of PCV2-associated disease. Can Vet J. 2007;48:716-24 pubmed
    ..with porcine circovirus type 2 (PCV2) at 3 days of age and then given 1 of 6 different commercial Mycoplasma hyopneumoniae (M...
  16. Cheikh Saad Bouh K, Shareck F, Dea S. Monoclonal antibodies to Escherichia coli-expressed P46 and P65 membranous proteins for specific immunodetection of Mycoplasma hyopneumoniae in lungs of infected pigs. Clin Diagn Lab Immunol. 2003;10:459-68 pubmed
    The P46 and P65 proteins of Mycoplasma hyopneumoniae are two membranous proteins carrying species-specific antigenic determinants...
  17. Mayor D, Zeeh F, Frey J, Kuhnert P. Diversity of Mycoplasma hyopneumoniae in pig farms revealed by direct molecular typing of clinical material. Vet Res. 2007;38:391-8 pubmed
    b>Mycoplasma hyopneumoniae is the etiological agent of enzootic pneumonia in swine. Various reports indicate that different strains are circulating in the swine population. We investigated the variety of M...
  18. de Castro L, Rodrigues Pedroso T, Kuchiishi S, Ramenzoni M, Kich J, Zaha A, et al. Variable number of tandem aminoacid repeats in adhesion-related CDS products in Mycoplasma hyopneumoniae strains. Vet Microbiol. 2006;116:258-69 pubmed
    The Mycoplasma hyopneumoniae genome contains at least 22 regions with a variable number of tandem nucleotide repeats (VNTRs) within coding DNA sequences (CDSs)...
  19. Ahn K, Kwon D, Jung K, Ha Y, Seo M, Kim S, et al. Identification of interleukin-1, tumor necrosis factor-alpha, and interleukin-6 expression in lungs from pigs naturally infected with Mycoplasma hyopneumoniae by in situ hybridization. J Vet Med Sci. 2009;71:441-5 pubmed
    ..probe, in formalin-fixed, paraffin-embedded lung tissue from 10 pigs naturally infected with Mycoplasma hyopneumoniae. The morphology of host cells was preserved despite the relatively high temperature required during the ..
  20. Sibila M, Pieters M, Molitor T, Maes D, Haesebrouck F, Segales J. Current perspectives on the diagnosis and epidemiology of Mycoplasma hyopneumoniae infection. Vet J. 2009;181:221-31 pubmed publisher
    b>Mycoplasma hyopneumoniae is the principal aetiological agent of enzootic pneumonia (EP), a chronic respiratory disease that affects mainly finishing pigs. Although major efforts to control M...
  21. Bai F, Ni B, Liu M, Feng Z, Xiong Q, Xiao S, et al. Mycoplasma hyopneumoniae-derived lipid-associated membrane proteins induce apoptosis in porcine alveolar macrophage via increasing nitric oxide production, oxidative stress, and caspase-3 activation. Vet Immunol Immunopathol. 2013;155:155-61 pubmed publisher
    b>Mycoplasma hyopneumoniae is the primary etiological agent of enzootic pneumonia in swine. Lipid-associated membrane proteins (LAMP) of mycoplasma are the main pathogenicity factors in mycoplasma diseases...
  22. Marois C, Dory D, Fablet C, Madec F, Kobisch M. Development of a quantitative Real-Time TaqMan PCR assay for determination of the minimal dose of Mycoplasma hyopneumoniae strain 116 required to induce pneumonia in SPF pigs. J Appl Microbiol. 2010;108:1523-33 pubmed publisher
    A triplex real-time PCR assay to quantify Mycoplasma hyopneumoniae in specimens from live and dead pigs was developed and validated. The minimal dose of Myc...
  23. Fano E, Pijoan C, Dee S. Infection dynamics of porcine reproductive and respiratory syndrome virus in a continuous-flow population of pigs also infected with Mycoplasma hyopneumoniae. Vet Rec. 2007;161:515-20 pubmed
    Twenty-eight 10-week-old pigs were inoculated intratracheally with 1 x 10(5) colour-changing units/ml Mycoplasma hyopneumoniae strain 232, and another 32 pigs were not inoculated but were divided into 12 direct-contact pigs and 20 ..
  24. Bandrick M, Pieters M, Pijoan C, Molitor T. Passive transfer of maternal Mycoplasma hyopneumoniae-specific cellular immunity to piglets. Clin Vaccine Immunol. 2008;15:540-3 pubmed publisher
    ..In this study we examined the transfer of vaccine-induced Mycoplasma hyopneumoniae cellular immunity from immune dams to newborn piglets...
  25. Marois C, Le Carrou J, Kobisch M, Gautier Bouchardon A. Isolation of Mycoplasma hyopneumoniae from different sampling sites in experimentally infected and contact SPF piglets. Vet Microbiol. 2007;120:96-104 pubmed
    ..Our results also suggested that tracheobronchiolar washings could have an influence on the lesion extent observed at necropsy. M. hyopneumoniae could be re-isolated from liver and spleen of experimentally infected pigs and contact pigs...
  26. Lorenzo H, Quesada O, Assunçao P, Castro A, Rodriguez F. Cytokine expression in porcine lungs experimentally infected with Mycoplasma hyopneumoniae. Vet Immunol Immunopathol. 2006;109:199-207 pubmed
    ..b>Mycoplasma hyopneumoniae (Mh) and proinflammatory and immunoregulatory cytokines (IL-1alpha, IL-1beta, IL-2, IL-4, IL-6, IL-8, IL-..
  27. Kügler J, Nieswandt S, Gerlach G, Meens J, Schirrmann T, Hust M. Identification of immunogenic polypeptides from a Mycoplasma hyopneumoniae genome library by phage display. Appl Microbiol Biotechnol. 2008;80:447-58 pubmed publisher
    ..and improved a M13 genomic phage display-based method for the selection of immunogenic polypeptides of Mycoplasma hyopneumoniae, a pathogen causing porcine enzootic pneumonia. The fragmented genome of M...
  28. Adams C, Pitzer J, Minion F. In vivo expression analysis of the P97 and P102 paralog families of Mycoplasma hyopneumoniae. Infect Immun. 2005;73:7784-7 pubmed
    The P97 adhesin and P102 genes of Mycoplasma hyopneumoniae each have six paralogs in the genome. We tested whether these genes were expressed during infection. P102 is associated with the mycoplasma and with swine cilia...
  29. Kuhnert P, Overesch G, Belloy L. Genotyping of Mycoplasma hyopneumoniae in wild boar lung samples. Vet Microbiol. 2011;152:191-5 pubmed publisher
    b>Mycoplasma hyopneumoniae is the etiologic agent of enzootic pneumonia (EP), an important cause of disease-associated losses in swine production and a role of wild boar in recurrent infections can be supposed. Genotypes of M...
  30. Weber S, Sant Anna F, Schrank I. Unveiling Mycoplasma hyopneumoniae promoters: sequence definition and genomic distribution. DNA Res. 2012;19:103-15 pubmed publisher
    ..species have had their genome completely sequenced, including four strains of the swine pathogen Mycoplasma hyopneumoniae. Nevertheless, little is known about the nucleotide sequences that control transcriptional initiation in ..
  31. Bandrick M, Pieters M, Pijoan C, Baidoo S, Molitor T. Effect of cross-fostering on transfer of maternal immunity to Mycoplasma hyopneumoniae to piglets. Vet Rec. 2011;168:100 pubmed publisher
    The aim of this study was to assess the effect of cross-fostering on transfer of maternal Mycoplasma hyopneumoniae-specific humoral and cell-mediated immunity (CMI) from gilts to piglets...
  32. Wilton J, Jenkins C, Cordwell S, Falconer L, Minion F, Oneal D, et al. Mhp493 (P216) is a proteolytically processed, cilium and heparin binding protein of Mycoplasma hyopneumoniae. Mol Microbiol. 2009;71:566-82 pubmed publisher
    b>Mycoplasma hyopneumoniae induces respiratory disease in swine by colonizing cilia causing ciliostasis, cilial loss and epithelial cell death. Heparin binds to M...
  33. Deutscher A, Tacchi J, Minion F, Padula M, Crossett B, Bogema D, et al. Mycoplasma hyopneumoniae Surface proteins Mhp385 and Mhp384 bind host cilia and glycosaminoglycans and are endoproteolytically processed by proteases that recognize different cleavage motifs. J Proteome Res. 2012;11:1924-36 pubmed publisher
    P97 and P102 paralogues occur as endoproteolytic cleavage fragments on the surface of Mycoplasma hyopneumoniae that bind glycosaminoglycans, plasminogen, and fibronectin and perform essential roles in colonization of ciliated epithelia...
  34. Hansen M, Pors S, Jensen H, Bille Hansen V, Bisgaard M, Flachs E, et al. An investigation of the pathology and pathogens associated with porcine respiratory disease complex in Denmark. J Comp Pathol. 2010;143:120-31 pubmed publisher
    ..and US type), porcine circovirus type 2 (PCV2), porcine respiratory coronavirus, porcine cytomegalovirus, Mycoplasma hyopneumoniae and Mycoplasma hyorhinis. All cases had cranioventral lobular bronchopneumonia consistent with PRDC...
  35. Steenhard N, Jungersen G, Kokotovic B, Beshah E, Dawson H, Urban J, et al. Ascaris suum infection negatively affects the response to a Mycoplasma hyopneumoniae vaccination and subsequent challenge infection in pigs. Vaccine. 2009;27:5161-9 pubmed publisher
    ..The hypothesis posed in this study was that a concurrent Ascaris suum infection of pigs vaccinated with a Mycoplasma hyopneumoniae (Mh) vaccine would modulate the protective immune response to a subsequent challenge infection...
  36. Zhang H, Lunney J, Baker R, Opriessnig T. Cytokine and chemokine mRNA expression profiles in tracheobronchial lymph nodes from pigs singularly infected or coinfected with porcine circovirus type 2 (PCV2) and Mycoplasma hyopneumoniae (MHYO). Vet Immunol Immunopathol. 2011;140:152-8 pubmed publisher
    ..in tracheobronchial lymph nodes from pigs singularly infected with porcine circovirus type 2 (PCV2), Mycoplasma hyopneumoniae (MHYO), or coinfected with both...
  37. Hwang M, Damte D, Lee J, Gebru E, Chang Z, Cheng H, et al. Mycoplasma hyopneumoniae induces pro-inflammatory cytokine and nitric oxide production through NF?B and MAPK pathways in RAW264.7 cells. Vet Res Commun. 2011;35:21-34 pubmed publisher
    ..In summary, we found critical evidence for the involvement of NF-?B and MAPK signaling pathways in the upregulation of proinflammatory cytokine and NO induced by M. hyopneumoniae...
  38. Matic J, Wilton J, Towers R, Scarman A, Minion F, Walker M, et al. The pyruvate dehydrogenase complex of Mycoplasma hyopneumoniae contains a novel lipoyl domain arrangement. Gene. 2003;319:99-106 pubmed
    The genes encoding the pyruvate dehydrogenase (PDH) complex (pdhA, pdhB, pdhC and pdhD) from Mycoplasma hyopneumoniae have been cloned and sequenced...
  39. Rodriguez F, Ramirez G, Sarradell J, Andrada M, Lorenzo H. Immunohistochemical labelling of cytokines in lung lesions of pigs naturally infected with Mycoplasma hyopneumoniae. J Comp Pathol. 2004;130:306-12 pubmed
    b>Mycoplasma hyopneumoniae (Mh) is the primary agent of porcine enzootic pneumonia (PEN), a chronic respiratory disease endemic to pig farms, and characterized histologically by infiltration of mononuclear cells in airways and prominent ..
  40. Vigre H, Dohoo I, Stryhn H, Busch M. Intra-unit correlations in seroconversion to Actinobacillus pleuropneumoniae and Mycoplasma hyopneumoniae at different levels in Danish multi-site pig production facilities. Prev Vet Med. 2004;63:9-28 pubmed
    ..production facilities regarding seroconversion to Actinobacillus pleuropneumoniae serotype 2 (Ap2) and Mycoplasma hyopneumoniae (Mh)...
  41. Le Carrou J, Laurentie M, Kobisch M, Gautier Bouchardon A. Persistence of Mycoplasma hyopneumoniae in experimentally infected pigs after marbofloxacin treatment and detection of mutations in the parC gene. Antimicrob Agents Chemother. 2006;50:1959-66 pubmed
    The ability of Mycoplasma hyopneumoniae to persist despite fluoroquinolone treatments was investigated with pigs. Groups of specific-pathogen-free pigs were experimentally infected with M...
  42. Moorkamp L, Hewicker Trautwein M, Grosse Beilage E. Occurrence of Mycoplasma hyopneumoniae in coughing piglets (3-6 weeks of age) from 50 herds with a history of endemic respiratory disease. Transbound Emerg Dis. 2009;56:54-6 pubmed publisher
    The objective of this study was to determine the occurrence of Mycoplasma hyopneumoniae in the lower respiratory tract of suckling and recently weaned pigs from herds with a history of endemic respiratory disease in this age group...
  43. Ameri Mahabadi M, Zhou E, Hsu W. Comparison of two swine Mycoplasma hyopneumoniae enzyme-linked immunosorbent assays for detection of antibodies from vaccinated pigs and field serum samples. J Vet Diagn Invest. 2005;17:61-4 pubmed
    b>Mycoplasma hyopneumoniae (Mhyo) causes mycoplasmal pneumonia, an economically important disease of swine...
  44. Madsen M, Oneal M, Gardner S, Strait E, Nettleton D, Thacker E, et al. Array-based genomic comparative hybridization analysis of field strains of Mycoplasma hyopneumoniae. J Bacteriol. 2007;189:7977-82 pubmed
    b>Mycoplasma hyopneumoniae is the causative agent of porcine enzootic pneumonia and a major factor in the porcine respiratory disease complex...
  45. Deblanc C, Robert F, Pinard T, Gorin S, Queguiner S, Gautier Bouchardon A, et al. Pre-infection of pigs with Mycoplasma hyopneumoniae induces oxidative stress that influences outcomes of a subsequent infection with a swine influenza virus of H1N1 subtype. Vet Microbiol. 2013;162:643-51 pubmed publisher
    ..influenza is highly variable and can be exacerbated by many factors, such as a pre-infection of pigs with Mycoplasma hyopneumoniae (Mhp)...
  46. Sibila M, Fort M, Nofrarias M, Perez de Rozas A, Galindo Cardiel I, Mateu E, et al. Simultaneous porcine circovirus type 2 and Mycoplasma hyopneumoniae co-inoculation does not potentiate disease in conventional pigs. J Comp Pathol. 2012;147:285-95 pubmed publisher
    ..of simultaneous experimental inoculation of porcine circovirus type 2 (PCV2; intranasal delivery) and Mycoplasma hyopneumoniae (Mhyo; transtracheal delivery) into conventional, seropositive 6-week-old piglets...
  47. Chen A, Fry S, Forbes Faulkner J, Daggard G, Mukkur T. Evaluation of the immunogenicity of the P97R1 adhesin of Mycoplasma hyopneumoniae as a mucosal vaccine in mice. J Med Microbiol. 2006;55:923-9 pubmed
    The immunogenicity of P97 adhesin repeat region R1 (P97R1) of Mycoplasma hyopneumoniae, an important pathogenesis-associated region of P97, was evaluated in mice as a mucosal vaccine...
  48. Deutscher A, Jenkins C, Minion F, Seymour L, Padula M, Dixon N, et al. Repeat regions R1 and R2 in the P97 paralogue Mhp271 of Mycoplasma hyopneumoniae bind heparin, fibronectin and porcine cilia. Mol Microbiol. 2010;78:444-58 pubmed publisher
    b>Mycoplasma hyopneumoniae, the causative agent of porcine enzootic pneumonia, adheres to ciliated respiratory epithelia resulting in ciliostasis and epithelial cell death...
  49. Madsen M, Nettleton D, Thacker E, Minion F. Transcriptional profiling of Mycoplasma hyopneumoniae during iron depletion using microarrays. Microbiology. 2006;152:937-44 pubmed
    b>Mycoplasma hyopneumoniae, the causative agent of swine enzootic pneumonia and a major component of the porcine respiratory disease complex, continues to confound swine producers despite control programmes worldwide...
  50. Siqueira F, Schrank A, Schrank I. Mycoplasma hyopneumoniae transcription unit organization: genome survey and prediction. DNA Res. 2011;18:413-22 pubmed publisher
    b>Mycoplasma hyopneumoniae is associated with swine respiratory diseases. Although gene organization and regulation are well known in many prokaryotic organisms, knowledge on mycoplasma is limited...
  51. Zeeh F, Kuhnert P, Miserez R, Doherr M, Zimmermann W. [Field validation of a real-time PCR test for the detection of Mycoplasma hyopneumoniae in nasal swabs of live pigs]. Schweiz Arch Tierheilkd. 2005;147:373-9 pubmed
    Enzootic pneumonia (EP) of pigs, caused by Mycoplasma hyopneumoniae has been a notifiable disease in Switzerland since May 2003...
  52. Seymour L, Falconer L, Deutscher A, Minion F, Padula M, Dixon N, et al. Mhp107 is a member of the multifunctional adhesin family of Mycoplasma hyopneumoniae. J Biol Chem. 2011;286:10097-104 pubmed publisher
    b>Mycoplasma hyopneumoniae is the causative pathogen of porcine enzootic pneumonia, an economically significant disease that disrupts the mucociliary escalator in the swine respiratory tract...
  53. Maes D, Segales J, Meyns T, Sibila M, Pieters M, Haesebrouck F. Control of Mycoplasma hyopneumoniae infections in pigs. Vet Microbiol. 2008;126:297-309 pubmed
    b>Mycoplasma hyopneumoniae, the primary pathogen of enzootic pneumonia, occurs worldwide and causes major economic losses to the pig industry. The organism adheres to and damages the ciliated epithelium of the respiratory tract...
  54. Opriessnig T, Madson D, Schalk S, Brockmeier S, Shen H, Beach N, et al. Porcine circovirus type 2 (PCV2) vaccination is effective in reducing disease and PCV2 shedding in semen of boars concurrently infected with PCV2 and Mycoplasma hyopneumoniae. Theriogenology. 2011;76:351-60 pubmed publisher
    ..of porcine circovirus type 2 (PCV2) shed in semen increased in boars experimentally coinfected with Mycoplasma hyopneumoniae (MHYO), and whether PCV2 vaccination of boars prior to PCV2 exposure reduced PCV2 viremia and virus ..
  55. Vicca J, Maes D, Jonker L, de Kruif A, Haesebrouck F. Efficacy of in-feed medication with tylosin for the treatment and control of Mycoplasma hyopneumoniae infections. Vet Rec. 2005;156:606-10 pubmed
    ..in-feed medication with tylosin for the treatment of enzootic pneumonia was examined in an experimental Mycoplasma hyopneumoniae infection model. One group of 10 conventional M...
  56. Nathues H, Kubiak R, Tegeler R, Grosse Beilage E. Occurrence of Mycoplasma hyopneumoniae infections in suckling and nursery pigs in a region of high pig density. Vet Rec. 2010;166:194-8 pubmed publisher
    The occurrence of Mycoplasma hyopneumoniae infections in young pigs was surveyed in a retrospective study of 1122 datasets obtained from routine diagnostics where either suckling or nursery pigs were examined for M hyopneumoniae in lung ..
  57. Marois C, Gottschalk M, Morvan H, Fablet C, Madec F, Kobisch M. Experimental infection of SPF pigs with Actinobacillus pleuropneumoniae serotype 9 alone or in association with Mycoplasma hyopneumoniae. Vet Microbiol. 2009;135:283-91 pubmed publisher
    ..The pathogenicity of one Mycoplasma hyopneumoniae strain alone or associated with A. pleuropneumoniae strain 21 was also compared...
  58. Zou H, Liu X, Ma F, Chen P, Zhou R, He Q. Attenuated Actinobacillus pleuropneumoniae as a bacterial vector for expression of Mycoplasma hyopneumoniae P36 gene. J Gene Med. 2011;13:221-9 pubmed publisher
    Actinobacillus pleuropneumoniae and Mycoplasma hyopneumoniae are causative agents of porcine pneumonia. Over the last few years, attenuated A. pleuropneumoniae live vaccines have been shown to provide protection against A...
  59. Liu W, Feng Z, Fang L, Zhou Z, Li Q, Li S, et al. Complete genome sequence of Mycoplasma hyopneumoniae strain 168. J Bacteriol. 2011;193:1016-7 pubmed publisher
    b>Mycoplasma hyopneumoniae strain 168, a pathogenic strain prevalent in China, was isolated in 1974. Although this strain has been widespread for a long time, the genome sequence had not been determined...
  60. Simionatto S, Marchioro S, Maes D, Dellagostin O. Mycoplasma hyopneumoniae: from disease to vaccine development. Vet Microbiol. 2013;165:234-42 pubmed publisher
    b>Mycoplasma hyopneumoniae is the etiological agent of swine enzootic pneumonia (EP), a disease that affects swine production worldwide. Vaccination is the most cost-effective strategy for the control and prevention of the disease...
  61. Jenkins C, Wilton J, Minion F, Falconer L, Walker M, Djordjevic S. Two domains within the Mycoplasma hyopneumoniae cilium adhesin bind heparin. Infect Immun. 2006;74:481-7 pubmed
    b>Mycoplasma hyopneumoniae is the causative agent of porcine enzootic pneumonia, a chronic and economically significant respiratory disease that affects swine production worldwide. M...
  62. Stakenborg T, Vicca J, Maes D, Peeters J, de Kruif A, Haesebrouck F, et al. Comparison of molecular techniques for the typing of Mycoplasma hyopneumoniae isolates. J Microbiol Methods. 2006;66:263-75 pubmed
    ..repeats (VNTR) of the P97 encoding gene, as possible methods for typing an international collection of Mycoplasma hyopneumoniae isolates. All techniques showed a typeability of 100% and high intraspecific diversity...
  63. Seymour L, Deutscher A, Jenkins C, Kuit T, Falconer L, Minion F, et al. A processed multidomain mycoplasma hyopneumoniae adhesin binds fibronectin, plasminogen, and swine respiratory cilia. J Biol Chem. 2010;285:33971-8 pubmed publisher
    ..The etiological agent of the disease, Mycoplasma hyopneumoniae, is a bacterium that adheres to cilia of the swine respiratory tract, resulting in loss of cilia and ..
  64. Wimmers K, Murani E, Schellander K, Ponsuksili S. QTL for traits related to humoral immune response estimated from data of a porcine F2 resource population. Int J Immunogenet. 2009;36:141-51 pubmed publisher
    ..in blood samples obtained from F2 piglets (n = 457) of a porcine F2 resource population before and after Mycoplasma hyopneumoniae, Aujeszky's disease virus (Suid herpesvirus I, SuHVI) and porcine reproductive and respiratory syndrome ..
  65. Thanawongnuwech R, Thacker B, Halbur P, Thacker E. Increased production of proinflammatory cytokines following infection with porcine reproductive and respiratory syndrome virus and Mycoplasma hyopneumoniae. Clin Diagn Lab Immunol. 2004;11:901-8 pubmed
    ..following experimental infection with porcine reproductive and respiratory syndrome virus (PRRSV) and/or Mycoplasma hyopneumoniae by using in vivo and in vitro models. The in vivo model consisted of pigs infected with PRRSV and/or M...
  66. Robinson M, Buchtmann K, Jenkins C, Tacchi J, Raymond B, To J, et al. MHJ_0125 is an M42 glutamyl aminopeptidase that moonlights as a multifunctional adhesin on the surface of Mycoplasma hyopneumoniae. Open Biol. 2013;3:130017 pubmed publisher
    ..We show that MHJ_0125 from the swine respiratory pathogen Mycoplasma hyopneumoniae represents a new member of the M42 class of bacterial aminopeptidases...
  67. Schmidt J, Browning G, Markham P. Mycoplasma hyopneumoniae mhp379 is a Ca2+-dependent, sugar-nonspecific exonuclease exposed on the cell surface. J Bacteriol. 2007;189:3414-24 pubmed
    b>Mycoplasma hyopneumoniae mhp379 is a putative lipoprotein that shares significant amino acid sequence similarity with a family of bacterial thermostable nucleases...
  68. He Y, Xu M, Zhou D, Zou F, Lin R, Yin C, et al. Seroprevalence of Mycoplasma hyopneumoniae in pigs in subtropical southern China. Trop Anim Health Prod. 2011;43:695-8 pubmed publisher
    Enzootic pneumonia caused by Mycoplasma hyopneumoniae is a severe disease of pigs, causing significant economic losses to the pig industry worldwide, including the tropical and subtropical regions...
  69. Otagiri Y, Asai T, Okada M, Uto T, Yazawa S, Hirai H, et al. Detection of Mycoplasma hyopneumoniae in lung and nasal swab samples from pigs by nested PCR and culture methods. J Vet Med Sci. 2005;67:801-5 pubmed
    ..nasal swab and lung homogenate samples collected from pigs experimentally and naturally infected with Mycoplasma hyopneumoniae for the detection of M. hyopneumoniae by the nested PCR (nPCR) and culture methods...
  70. Villarreal I, Meyns T, Dewulf J, Vranckx K, Calus D, Pasmans F, et al. The effect of vaccination on the transmission of Mycoplasma hyopneumoniae in pigs under field conditions. Vet J. 2011;188:48-52 pubmed publisher
    This study investigated the effect of vaccination against Mycoplasma hyopneumoniae on its transmission in nursery pigs under field conditions...
  71. Calus D, Maes D, Vranckx K, Villareal I, Pasmans F, Haesebrouck F. Validation of ATP luminometry for rapid and accurate titration of Mycoplasma hyopneumoniae in Friis medium and a comparison with the color changing units assay. J Microbiol Methods. 2010;83:335-40 pubmed publisher
    Limited reports are available on the growth response of Mycoplasma hyopneumoniae in Friis medium and the routinely used color changing units (CCU) assay has not yet been profoundly compared with other titration methods...
  72. Kim T, Cho H, Park N, Lee J. Serodiagnostic comparison between two methods, ELISA and surface plasmon resonance for the detection of antibody titres of Mycoplasma hyopneumoniae. J Vet Med B Infect Dis Vet Public Health. 2006;53:87-90 pubmed
    A protein chip based on surface plasmon resonance (SPR) was developed for measuring the Mycoplasma hyopneumoniae antibody titres using a recombinant 30-kDa fragment of P97 adhesin as an antigen...
  73. Bogema D, Scott N, Padula M, Tacchi J, Raymond B, Jenkins C, et al. Sequence TTKF ? QE defines the site of proteolytic cleavage in Mhp683 protein, a novel glycosaminoglycan and cilium adhesin of Mycoplasma hyopneumoniae. J Biol Chem. 2011;286:41217-29 pubmed publisher
    b>Mycoplasma hyopneumoniae colonizes the ciliated respiratory epithelium of swine, disrupting mucociliary function and inducing chronic inflammation. P97 and P102 family members are major surface proteins of M...
  74. Fablet C, Marois C, Kobisch M, Madec F, Rose N. Estimation of the sensitivity of four sampling methods for Mycoplasma hyopneumoniae detection in live pigs using a Bayesian approach. Vet Microbiol. 2010;143:238-45 pubmed publisher
    Four sampling techniques for Mycoplasma hyopneumoniae detection, namely nasal swabbing, oral-pharyngeal brushing, tracheo-bronchial swabbing and tracheo-bronchial washing, were compared in naturally infected live pigs...
  75. Pieters M, Fano E, Pijoan C, Dee S. An experimental model to evaluate Mycoplasma hyopneumoniae transmission from asymptomatic carriers to unvaccinated and vaccinated sentinel pigs. Can J Vet Res. 2010;74:157-60 pubmed
    ..of this study was to determine the effect of vaccinating susceptible animals on the transmission of Mycoplasma hyopneumoniae from experimentally infected pigs during the chronic phase of infection...
  76. Dee S, Otake S, Oliveira S, Deen J. Evidence of long distance airborne transport of porcine reproductive and respiratory syndrome virus and Mycoplasma hyopneumoniae. Vet Res. 2009;40:39 pubmed publisher
    The ability of porcine reproductive and respiratory syndrome virus (PRRSV) and Mycoplasma hyopneumoniae to be transported over long distances via the airborne route was evaluated...
  77. Kim D, Kim C, Han K, Seo H, Oh Y, Park C, et al. Comparative efficacy of commercial Mycoplasma hyopneumoniae and porcine circovirus 2 (PCV2) vaccines in pigs experimentally infected with M. hyopneumoniae and PCV2. Vaccine. 2011;29:3206-12 pubmed publisher
    The efficacies of two commercial Mycoplasma hyopneumoniae bacterins and porcine circovirus 2 (PCV2) vaccines were compared in conventional pigs immunized at different ages based on humoral response, pathological observation, and growth ..
  78. Li Y, Ho Y, Chen S, Chiou T, Li Z, Shiuan D. Proteomic comparative analysis of pathogenic strain 232 and avirulent strain J of Mycoplasma hyopneumoniae. Biochemistry (Mosc). 2009;74:215-20 pubmed
    b>Mycoplasma hyopneumoniae is an important pathogen of pigs causing enzootic pneumonia of swine. The pathogen remains largely enigmatic as far as the host-pathogen interactions are concerned...
  79. Muneta Y, Uenishi H, Kikuma R, Yoshihara K, Shimoji Y, Yamamoto R, et al. Porcine TLR2 and TLR6: identification and their involvement in Mycoplasma hyopneumoniae infection. J Interferon Cytokine Res. 2003;23:583-90 pubmed
    ..tumor necrosis factor-alpha (TNF-alpha) production by porcine alveolar macrophages stimulated with Mycoplasma hyopneumoniae. These results indicated that both TLR2 and TLR6 are important in the recognition of M...
  80. Marchioro S, Maes D, Flahou B, Pasmans F, Del Pozo Sacristán R, Vranckx K, et al. Local and systemic immune responses in pigs intramuscularly injected with an inactivated Mycoplasma hyopneumoniae vaccine. Vaccine. 2013;31:1305-11 pubmed publisher
    ..These results show that the vaccine induced both systemic and mucosal cellular and humoral immune responses...
  81. Yazawa S, Okada M, Ono M, Fujii S, Okuda Y, Shibata I, et al. Experimental dual infection of pigs with an H1N1 swine influenza virus (A/Sw/Hok/2/81) and Mycoplasma hyopneumoniae. Vet Microbiol. 2004;98:221-8 pubmed
    Dual infection of pigs with swine influenza virus (SIV) and Mycoplasma hyopneumoniae was carried out to compare the clinical and pathological effects of dual infection in caesarian derived and colostrums deprived (CDCD) pigs, with that of ..
  82. Mayor D, Jores J, Korczak B, Kuhnert P. Multilocus sequence typing (MLST) of Mycoplasma hyopneumoniae: a diverse pathogen with limited clonality. Vet Microbiol. 2008;127:63-72 pubmed
    A multilocus sequence typing (MLST) scheme was established and evaluated for Mycoplasma hyopneumoniae, the etiologic agent of enzootic pneumonia in swine with the aim of defining strains...