mycoplasma genitalium

Summary

Summary: A species of gram-negative bacteria originally isolated from urethral specimens of patients with non-gonoccocal URETHRITIS. In primates it exists in parasitic association with ciliated EPITHELIAL CELLS in the genital and respiratory tracts.

Top Publications

  1. Mena L, Mroczkowski T, Nsuami M, Martin D. A randomized comparison of azithromycin and doxycycline for the treatment of Mycoplasma genitalium-positive urethritis in men. Clin Infect Dis. 2009;48:1649-54 pubmed publisher
    ..studies have suggested that the tetracycline class of antibiotics may not be effective in treating Mycoplasma genitalium infection...
  2. Rahman S, Garland S, Currie M, Tabrizi S, Rahman M, Nessa K, et al. Prevalence of Mycoplasma genitalium in health clinic attendees complaining of vaginal discharge in Bangladesh. Int J STD AIDS. 2008;19:772-4 pubmed publisher
    The objective of the study was to determine the prevalence of Mycoplasma genitalium in a sample of health clinic attendees complaining of vaginal discharge...
  3. Sluijter M, Estevão S, Hoogenboezem T, Hartwig N, van Rossum A, Vink C. The RuvA homologues from Mycoplasma genitalium and Mycoplasma pneumoniae exhibit unique functional characteristics. PLoS ONE. 2012;7:e38301 pubmed publisher
    The DNA recombination and repair machineries of Mycoplasma genitalium and Mycoplasma pneumoniae differ considerably from those of gram-positive and gram-negative bacteria. Most notably, M...
  4. Vandepitte J, Weiss H, Bukenya J, Nakubulwa S, Mayanja Y, Matovu G, et al. Alcohol use, mycoplasma genitalium, and other STIs associated With HIV incidence among women at high risk in Kampala, Uganda. J Acquir Immune Defic Syndr. 2013;62:119-26 pubmed publisher
    ..HIV incidence was also independently associated with Mycoplasma genitalium infection at enrolment [adjusted hazard ratio (aHR) = 2.28, 95% confidence interval (CI): 1.15 to 4...
  5. Edberg A, Jurstrand M, Johansson E, Wikander E, Höög A, Ahlqvist T, et al. A comparative study of three different PCR assays for detection of Mycoplasma genitalium in urogenital specimens from men and women. J Med Microbiol. 2008;57:304-9 pubmed publisher
    ..aim of this study was to compare conventional 16S rRNA gene PCR, real-time 16S rRNA gene PCR and real-time Mycoplasma genitalium adhesin protein (MgPa) gene PCR as detection methods for M. genitalium infection...
  6. Benders G, Powell B, Hutchison C. Transcriptional analysis of the conserved ftsZ gene cluster in Mycoplasma genitalium and Mycoplasma pneumoniae. J Bacteriol. 2005;187:4542-51 pubmed
    ..detailed transcriptional profile of the phylogenetically conserved ftsZ cell division gene cluster in both Mycoplasma genitalium and its closest relative, Mycoplasma pneumoniae...
  7. Gdoura R, Kchaou W, Chaari C, Znazen A, Keskes L, Rebai T, et al. Ureaplasma urealyticum, Ureaplasma parvum, Mycoplasma hominis and Mycoplasma genitalium infections and semen quality of infertile men. BMC Infect Dis. 2007;7:129 pubmed
    Genital ureaplasmas (Ureaplasma urealyticum and Ureaplasma parvum) and mycoplasmas (Mycoplasma genitalium and Mycoplasma hominis) are potentially pathogenic species playing an etiologic role in both genital infections and male ..
  8. Walker J, Fairley C, Bradshaw C, Tabrizi S, Twin J, Chen M, et al. Mycoplasma genitalium incidence, organism load, and treatment failure in a cohort of young Australian women. Clin Infect Dis. 2013;56:1094-100 pubmed publisher
    b>Mycoplasma genitalium (MG) is an emerging sexually transmitted infection (STI) that is potentially associated with reproductive tract sequelae in women...
  9. Takahashi S, Takeyama K, Miyamoto S, Ichihara K, Maeda T, Kunishima Y, et al. Detection of Mycoplasma genitalium, Mycoplasma hominis, Ureaplasma urealyticum, and Ureaplasma parvum DNAs in urine from asymptomatic healthy young Japanese men. J Infect Chemother. 2006;12:269-71 pubmed
    ..A survey of 100 asymptomatic healthy male volunteers was carried out. C. trachomatis, Mycoplasma genitalium, Mycoplasma hominis, Ureaplasma urealyticum, and Ureaplasma parvum in first-voided urine specimens were ..

More Information

Publications102 found, 100 shown here

  1. Ueno P, Timenetsky J, Centonze V, Wewer J, Cagle M, Stein M, et al. Interaction of Mycoplasma genitalium with host cells: evidence for nuclear localization. Microbiology. 2008;154:3033-41 pubmed publisher
    b>Mycoplasma genitalium (Mg) is a mollicute that causes a range of human urogenital infections...
  2. McGowin C, Ma L, Martin D, Pyles R. Mycoplasma genitalium-encoded MG309 activates NF-kappaB via Toll-like receptors 2 and 6 to elicit proinflammatory cytokine secretion from human genital epithelial cells. Infect Immun. 2009;77:1175-81 pubmed publisher
    b>Mycoplasma genitalium has been implicated in several important reproductive tract syndromes in women, including pelvic inflammatory disease, cervicitis, and tubal factor infertility...
  3. Carlsen K, Jensen J. Mycoplasma genitalium PCR: does freezing of specimens affect sensitivity?. J Clin Microbiol. 2010;48:3624-7 pubmed publisher
    b>Mycoplasma genitalium is an established cause of sexually transmitted infections...
  4. Mellenius H, Boman J, Lundqvist E, Jensen J. [Mycoplasma genitalium should be suspected in unspecific urethritis and cervicitis. A study from Vasterbotten confirms the high prevalence of the bacteria]. Lakartidningen. 2005;102:3538, 3540-1 pubmed
    The microbe Mycoplasma genitalium has in several studies been proposed as an individual cause of non-gonococcal urethritis (NGU) in men, and has been associated with pelvic inflammatory disease (PID) and salpingitis...
  5. Taylor B, Ness R, Darville T, Haggerty C. Microbial correlates of delayed care for pelvic inflammatory disease. Sex Transm Dis. 2011;38:434-8 pubmed publisher
    ..before care were compared by microbial pathogen (Chlamydia trachomatis only, Neisseria gonorrhoeae only, Mycoplasma genitalium only, coinfection with 2 or more pathogens, or no pathogens) among 298 women with histologically confirmed ..
  6. Oakeshott P, Hay P, Taylor Robinson D, Hay S, Dohn B, Kerry S, et al. Prevalence of Mycoplasma genitalium in early pregnancy and relationship between its presence and pregnancy outcome. BJOG. 2004;111:1464-7 pubmed
    b>Mycoplasma genitalium is associated with cervicitis and pelvic inflammatory disease but little is known about its role in pregnancy. We investigated the prevalence of M...
  7. Bjartling C, Osser S, Persson K. The association between Mycoplasma genitalium and pelvic inflammatory disease after termination of pregnancy. BJOG. 2010;117:361-4 pubmed publisher
    The prevalence and complications of Mycoplasma genitalium and Chlamydia trachomatis infections among women undergoing termination of pregnancy were studied in this nested case-control study at Malmo University Hospital, Sweden, during ..
  8. Sluijter M, Kaptein E, Spuesens E, Hoogenboezem T, Hartwig N, van Rossum A, et al. The Mycoplasma genitalium MG352-encoded protein is a Holliday junction resolvase that has a non-functional orthologue in Mycoplasma pneumoniae. Mol Microbiol. 2010;77:1261-77 pubmed publisher
    ..Here, we describe the proteins encoded by the Mycoplasma genitalium MG352 and Mycoplasma pneumoniae MPN528a genes (RecU(Mge) and RecU(Mpn) respectively), which share sequence ..
  9. Jensen J, Björnelius E, Dohn B, Lidbrink P. Use of TaqMan 5' nuclease real-time PCR for quantitative detection of Mycoplasma genitalium DNA in males with and without urethritis who were attendees at a sexually transmitted disease clinic. J Clin Microbiol. 2004;42:683-92 pubmed
    b>Mycoplasma genitalium is a cause of nongonococcal urethritis, particularly in patients not infected with Chlamydia trachomatis. A quantitative 5' nuclease assay (TaqMan PCR) was developed and validated...
  10. Ma L, Taylor S, Jensen J, Myers L, Lillis R, Martin D. Short tandem repeat sequences in the Mycoplasma genitalium genome and their use in a multilocus genotyping system. BMC Microbiol. 2008;8:130 pubmed publisher
    Several methods have been reported for strain typing of Mycoplasma genitalium. The value of these methods has never been comparatively assessed...
  11. Hamasuna R. Identification of treatment strategies for Mycoplasma genitalium-related urethritis in male patients by culturing and antimicrobial susceptibility testing. J Infect Chemother. 2013;19:1-11 pubmed publisher
    b>Mycoplasma genitalium was first isolated from urethral swab specimens of male patients with non-gonococcal urethritis. However, the isolation of M. genitalium strains from clinical specimens has been difficult...
  12. Reinton N, Moi H, Olsen A, Zarabyan N, Bjerner J, Tønseth T, et al. Anatomic distribution of Neisseria gonorrhoeae, Chlamydia trachomatis and Mycoplasma genitalium infections in men who have sex with men. Sex Health. 2013;10:199-203 pubmed publisher
    ..The aim of this study was to determine the prevalence and sites of infection of common sexually transmissible infections (STIs) in men who have sex with men (MSM)...
  13. Gaydos C, Maldeis N, Hardick A, Hardick J, Quinn T. Mycoplasma genitalium as a contributor to the multiple etiologies of cervicitis in women attending sexually transmitted disease clinics. Sex Transm Dis. 2009;36:598-606 pubmed publisher
    ..to investigate the prevalence of Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, and Mycoplasma genitalium, in women attending a sexually transmitted disease (STD) clinic, as well as the frequency of coinfections, ..
  14. Vandepitte J, Muller E, Bukenya J, Nakubulwa S, Kyakuwa N, Buve A, et al. Prevalence and correlates of Mycoplasma genitalium infection among female sex workers in Kampala, Uganda. J Infect Dis. 2012;205:289-96 pubmed publisher
    The importance of Mycoplasma genitalium in human immunodeficiency virus (HIV)-burdened sub-Saharan Africa is relatively unknown...
  15. Anagrius C, Loré B, Jensen J. Treatment of Mycoplasma genitalium. Observations from a Swedish STD clinic. PLoS ONE. 2013;8:e61481 pubmed publisher
    To evaluate therapy for Mycoplasma genitalium infection with doxycycline or azithromycin 1 g compared to five days of azithromycin (total dose 1.5 g)...
  16. Jensen J. Mycoplasma genitalium: the aetiological agent of urethritis and other sexually transmitted diseases. J Eur Acad Dermatol Venereol. 2004;18:1-11 pubmed
    b>Mycoplasma genitalium was first isolated in 1980 from two of 13 men with non-gonococcal urethritis (NGU). It shares several features with M. pneumoniae, a recognized respiratory tract pathogen...
  17. Iverson Cabral S, Astete S, Cohen C, Totten P. mgpB and mgpC sequence diversity in Mycoplasma genitalium is generated by segmental reciprocal recombination with repetitive chromosomal sequences. Mol Microbiol. 2007;66:55-73 pubmed
    b>Mycoplasma genitalium is associated with sexually transmitted infections in men and women that, if untreated, can persist, suggesting that mechanism(s) exist to facilitate immune evasion. Approximately 4% of the limited M...
  18. Lusk M, Konecny P, Naing Z, Garden F, Cumming R, Rawlinson W. Mycoplasma genitalium is associated with cervicitis and HIV infection in an urban Australian STI clinic population. Sex Transm Infect. 2011;87:107-9 pubmed publisher
    To investigate the prevalence of the genital mollicutes, Mycoplasma genitalium (MG), Mycoplasma hominis (MH), Ureaplasma urealyticum (UU) and Ureaplasma parvum (UP), and their associations with cervicitis in a sexually transmitted ..
  19. Jensen A, Kleveland C, Moghaddam A, Haaheim H, Hjelmevoll S, Skogen V. Chlamydia trachomatis, Mycoplasma genitalium and Ureaplasma urealyticum among students in northern Norway. J Eur Acad Dermatol Venereol. 2013;27:e91-6 pubmed publisher
    The prevalence of Mycoplasma genitalium and Ureaplasma genitalium in populations outside sexually transmitted infection clinics in Norway is unknown...
  20. Couldwell D, Tagg K, Jeoffreys N, Gilbert G. Failure of moxifloxacin treatment in Mycoplasma genitalium infections due to macrolide and fluoroquinolone resistance. Int J STD AIDS. 2013;24:822-8 pubmed publisher
    Increasing azithromycin treatment failure in sexually transmitted Mycoplasma genitalium infection, is linked to macrolide resistance and second-line treatment relies on the fluoroquinolone, moxifloxacin...
  21. Björnelius E, Anagrius C, Bojs G, Carlberg H, Johannisson G, Johansson E, et al. Antibiotic treatment of symptomatic Mycoplasma genitalium infection in Scandinavia: a controlled clinical trial. Sex Transm Infect. 2008;84:72-6 pubmed
    ..The extended course of azithromycin was highly effective but was given after the initial treatment with doxycycline. Randomised clinical trials are needed to compare the different dosages of azithromycin. ..
  22. Wu Y, Qiu H, Zeng Y, You X, Deng Z, Yu M, et al. Mycoplasma genitalium lipoproteins induce human monocytic cell expression of proinflammatory cytokines and apoptosis by activating nuclear factor kappaB. Mediators Inflamm. 2008;2008:195427 pubmed publisher
    ..expression and apoptosis in human monocytic cell line THP-1 stimulated by lipoproteins (LPs) prepared from Mycoplasma genitalium. Cultured cells were stimulated with M...
  23. McGowin C, Annan R, Quayle A, Greene S, Ma L, Mancuso M, et al. Persistent Mycoplasma genitalium infection of human endocervical epithelial cells elicits chronic inflammatory cytokine secretion. Infect Immun. 2012;80:3842-9 pubmed publisher
    Infection with Mycoplasma genitalium has been associated with male and female urogenital disease syndromes, including urethritis, cervicitis, pelvic inflammatory disease (PID), and tubal factor infertility...
  24. Pich O, Burgos R, Planell R, Querol E, Piñol J. Comparative analysis of antibiotic resistance gene markers in Mycoplasma genitalium: application to studies of the minimal gene complement. Microbiology. 2006;152:519-27 pubmed
    b>Mycoplasma genitalium has been proposed as a suitable model for an in-depth understanding of the biology of a free-living organism...
  25. Soni S, Alexander S, Verlander N, Saunders P, Richardson D, Fisher M, et al. The prevalence of urethral and rectal Mycoplasma genitalium and its associations in men who have sex with men attending a genitourinary medicine clinic. Sex Transm Infect. 2010;86:21-4 pubmed publisher
    To determine the prevalence of rectal and urethral Mycoplasma genitalium (MG) in men who have sex with men (MSM) attending a genitourinary medicine clinic and to measure its associations with symptoms, clinical signs, sexual behaviour ..
  26. Short V, Jensen J, Nelson D, Murray P, Ness R, Haggerty C. Mycoplasma genitalium among young, urban pregnant women. Infect Dis Obstet Gynecol. 2010;2010:984760 pubmed publisher
    As the consequences of Mycoplasma genitalium in pregnant women are unknown, we examined the relationship between prenatal M. genitalium infection and SAB.
  27. Pingmin W, Yuepu P, Jiwen Z. Prevalence survey on condom use and infection of urogenital mycoplasmas in female sex workers in China. Contraception. 2005;72:217-20 pubmed
    ..were interviewed, and three mycoplasmas of Ureaplasma urealyticum (Uu), Mycoplasma hominis (Mh) and Mycoplasma genitalium (Mg) were detected by nested polymerase chain reaction in genital secretions of 72 female sex workers and ..
  28. Wroblewski J, Manhart L, Dickey K, Hudspeth M, Totten P. Comparison of transcription-mediated amplification and PCR assay results for various genital specimen types for detection of Mycoplasma genitalium. J Clin Microbiol. 2006;44:3306-12 pubmed
    b>Mycoplasma genitalium is now recognized as a possible cause of several idiopathic sexually transmitted disease (STD) syndromes...
  29. Jensen J, Bradshaw C, Tabrizi S, Fairley C, Hamasuna R. Azithromycin treatment failure in Mycoplasma genitalium-positive patients with nongonococcal urethritis is associated with induced macrolide resistance. Clin Infect Dis. 2008;47:1546-53 pubmed publisher
    b>Mycoplasma genitalium is a common cause of nongonococcal urethritis. Treatment trials have shown that doxycycline is inefficient, whereas a 5-day course of azithromycin eradicates the bacterium from 95% of infected men...
  30. Jernberg E, Moghaddam A, Moi H. Azithromycin and moxifloxacin for microbiological cure of Mycoplasma genitalium infection: an open study. Int J STD AIDS. 2008;19:676-9 pubmed publisher
    There are no evidence-based guidelines for the treatment of Mycoplasma genitalium-positive genital infection. In a retrospective survey, we analysed the treatment results of patients tested for M...
  31. Moi H, Reinton N, Moghaddam A. Mycoplasma genitalium in women with lower genital tract inflammation. Sex Transm Infect. 2009;85:10-4 pubmed publisher
    To examine the prevalence of Mycoplasma genitalium in a large number of female patients attending a sexually transmitted infections (STI) clinic and to determine if there is an association with signs or symptoms of lower genital tract ..
  32. Gdoura R, Kchaou W, Ammar Keskes L, Chakroun N, Sellemi A, Znazen A, et al. Assessment of Chlamydia trachomatis, Ureaplasma urealyticum, Ureaplasma parvum, Mycoplasma hominis, and Mycoplasma genitalium in semen and first void urine specimens of asymptomatic male partners of infertile couples. J Androl. 2008;29:198-206 pubmed
    ..ureaplasmas (Ureaplasma urealyticum and Ureaplasma parvum) and genital mycoplasmas (Mycoplasma hominis and Mycoplasma genitalium). Semen analysis was assessed according to the guidelines of the World Health Organization...
  33. Hamasuna R, Imai H, Tsukino H, Jensen J, Osada Y. Prevalence of Mycoplasma genitalium among female students in vocational schools in Japan. Sex Transm Infect. 2008;84:303-5 pubmed publisher
    ..Most of them were asymptomatic, which may lead to continuing spread of the infection. Like C trachomatis, Mycoplasma genitalium is a pathogen in male non-gonococcal urethritis...
  34. Sluijter M, Spuesens E, Hartwig N, van Rossum A, Vink C. The Mycoplasma pneumoniae MPN490 and Mycoplasma genitalium MG339 genes encode reca homologs that promote homologous DNA strand exchange. Infect Immun. 2009;77:4905-11 pubmed publisher
    The P1, P40, and P90 proteins of Mycoplasma pneumoniae and the MgPa and P110 proteins of Mycoplasma genitalium are immunogenic adhesion proteins that display sequence variation...
  35. Bjartling C, Osser S, Persson K. Mycoplasma genitalium in cervicitis and pelvic inflammatory disease among women at a gynecologic outpatient service. Am J Obstet Gynecol. 2012;206:476.e1-8 pubmed publisher
    We sought to analyze the prevalence and clinical manifestations of Mycoplasma genitalium infection in a heterogeneous population of women.
  36. Zhang W, Baseman J. Functional characterization of osmotically inducible protein C (MG_427) from Mycoplasma genitalium. J Bacteriol. 2014;196:1012-9 pubmed publisher
    b>Mycoplasma genitalium is the smallest self-replicating bacterium and an important human pathogen responsible for a range of urogenital infections and pathologies...
  37. Taylor Robinson D, Horner P. Mycoplasma genitalium and asymptomatic chlamydia-negative non-gonococcal urethritis revisited. Int J STD AIDS. 2005;16:768-9 pubmed
  38. Huppert J, Mortensen J, Reed J, Kahn J, Rich K, Hobbs M. Mycoplasma genitalium detected by transcription-mediated amplification is associated with Chlamydia trachomatis in adolescent women. Sex Transm Dis. 2008;35:250-4 pubmed publisher
    The clinical significance of Mycoplasma genitalium (MG) infection in adolescent women is poorly understood...
  39. McGowin C, Popov V, Pyles R. Intracellular Mycoplasma genitalium infection of human vaginal and cervical epithelial cells elicits distinct patterns of inflammatory cytokine secretion and provides a possible survival niche against macrophage-mediated killing. BMC Microbiol. 2009;9:139 pubmed publisher
    b>Mycoplasma genitalium is an emerging sexually transmitted pathogen that has been associated with significant reproductive tract inflammatory syndromes in women. In addition, the strong association between severity of M...
  40. Twin J, Taylor N, Garland S, Hocking J, Walker J, Bradshaw C, et al. Comparison of two Mycoplasma genitalium real-time PCR detection methodologies. J Clin Microbiol. 2011;49:1140-2 pubmed publisher
    Established in-house quantitative PCR (qPCR) assays to detect the Mycoplasma genitalium adhesion protein (MgPa) and the 16S rRNA gene were found to be comparable for screening purposes, with a kappa value of 0...
  41. Mirnejad R, Amirmozafari N, Kazemi B. Simultaneous and rapid differential diagnosis of Mycoplasma genitalium and Ureaplasma urealyticum based on a polymerase chain reaction-restriction fragment length polymorphism. Indian J Med Microbiol. 2011;29:33-6 pubmed publisher
    The aim of this investigation was to simultaneously detect and differentiate Mycoplasma genitalium and Ureaplasma urealyticum in female patients suffering from genital complications by polymerase chain reaction (PCR)-restriction fragment ..
  42. Svenstrup H, Jensen J, Gevaert K, Birkelund S, Christiansen G. Identification and characterization of immunogenic proteins of mycoplasma genitalium. Clin Vaccine Immunol. 2006;13:913-22 pubmed
    b>Mycoplasma genitalium causes nonchlamydial nongonococcal urethritis. M. genitalium was detected by PCR in 17 urethral swabs obtained from 99 men with and without urethritis (J. S. Jensen, R. Orsum, B. Dohn, S. Uldum, A. M. Worm, and K...
  43. Pich O, Burgos R, Ferrer Navarro M, Querol E, Piñol J. Role of Mycoplasma genitalium MG218 and MG317 cytoskeletal proteins in terminal organelle organization, gliding motility and cytadherence. Microbiology. 2008;154:3188-98 pubmed publisher
    ..For this reason, the analysis of Mycoplasma genitalium mutants displaying anomalous terminal organelles could improve our knowledge regarding the structural ..
  44. Deguchi T, Yasuda M, Yokoi S, Nakano M, Ito S, Ohkusu K, et al. Failure to detect Mycoplasma genitalium in the pharynges of female sex workers in Japan. J Infect Chemother. 2009;15:410-3 pubmed publisher
    ..Neisseria gonorrhoeae, Chlamydia trachomatis, Mycoplasma genitalium, Mycoplasma hominis, Ureaplasma parvum, and Ureaplasma urealyticum in vaginal and throat specimens were ..
  45. Mavedzenge S, Van Der Pol B, Weiss H, Kwok C, Mambo F, Chipato T, et al. The association between Mycoplasma genitalium and HIV-1 acquisition in African women. AIDS. 2012;26:617-24 pubmed publisher
    b>Mycoplasma genitalium is an emerging sexually transmitted infection (STI) and has been associated with reproductive tract infections and HIV in cross-sectional studies. In this longitudinal study, we assess whether M...
  46. Mobley V, Hobbs M, Lau K, Weinbaum B, Getman D, Sena A. Mycoplasma genitalium infection in women attending a sexually transmitted infection clinic: diagnostic specimen type, coinfections, and predictors. Sex Transm Dis. 2012;39:706-9 pubmed publisher
    In female sexually transmitted infection clinic attendees, Mycoplasma genitalium was more frequently detected using vaginal (53/73) versus endocervical (43/73) specimens. In women without other sexually transmitted infections, M...
  47. Ishihara S, Yasuda M, Ito S, Maeda S, Deguchi T. Mycoplasma genitalium urethritis in men. Int J Antimicrob Agents. 2004;24 Suppl 1:S23-7 pubmed
    b>Mycoplasma genitalium was first isolated from two men with non-gonococcal urethritis (NGU) and thereafter shown to produce urethritis in subhuman primates, inoculated intraurethrally...
  48. Ross J, Jensen J. Mycoplasma genitalium as a sexually transmitted infection: implications for screening, testing, and treatment. Sex Transm Infect. 2006;82:269-71 pubmed
    The evidence that Mycoplasma genitalium is a sexually transmitted pathogen is virtually incontrovertible based on both the concordance rates among partners and on DNA typing showing the same sequence type among partners in contrast to ..
  49. Haggerty C, Totten P, Astete S, Ness R. Mycoplasma genitalium among women with nongonococcal, nonchlamydial pelvic inflammatory disease. Infect Dis Obstet Gynecol. 2006;2006:30184 pubmed
    ..We detected M genitalium in 7 (14%) of the women tested: 6 (12%) in cervical specimens and 4 (8%) in endometrial specimens. We conclude that M genitalium is prevalent in the endometrium of women with nongonococcal, nonchlamydial PID...
  50. Haggerty C, Totten P, Astete S, Lee S, Hoferka S, Kelsey S, et al. Failure of cefoxitin and doxycycline to eradicate endometrial Mycoplasma genitalium and the consequence for clinical cure of pelvic inflammatory disease. Sex Transm Infect. 2008;84:338-42 pubmed publisher
    As Mycoplasma genitalium is associated with pelvic inflammatory disease (PID), we examined the efficacy of a commonly used PID antimicrobial in treating M genitalium upper genital tract infection.
  51. Moi H, Reinton N, Moghaddam A. Mycoplasma genitalium is associated with symptomatic and asymptomatic non-gonococcal urethritis in men. Sex Transm Infect. 2009;85:15-8 pubmed publisher
    To examine the prevalence of Mycoplasma genitalium in a large number of male patients attending a sexually transmitted infections (STI) clinic and to determine if there is an association with objective non-gonococcal urethritis (NGU) in ..
  52. McGowin C, Anderson Smits C. Mycoplasma genitalium: an emerging cause of sexually transmitted disease in women. PLoS Pathog. 2011;7:e1001324 pubmed publisher
    b>Mycoplasma genitalium is an emerging sexually transmitted pathogen implicated in urethritis in men and several inflammatory reproductive tract syndromes in women including cervicitis, pelvic inflammatory disease (PID), and infertility...
  53. Blaylock M, Musatovova O, Baseman J, Baseman J. Determination of infectious load of Mycoplasma genitalium in clinical samples of human vaginal cells. J Clin Microbiol. 2004;42:746-52 pubmed
    b>Mycoplasma genitalium is a leading cause of chlamydia-negative, nongonoccocal urethritis and has been directly implicated in numerous other genitourinary as well as extragenitourinary tract pathologies. Detection of M...
  54. Hamasuna R, Osada Y, Jensen J. Antibiotic susceptibility testing of Mycoplasma genitalium by TaqMan 5' nuclease real-time PCR. Antimicrob Agents Chemother. 2005;49:4993-8 pubmed
    b>Mycoplasma genitalium is an important pathogen in male nongonococcal urethritis (NGU). Isolation of M...
  55. Anagrius C, Loré B, Jensen J. Mycoplasma genitalium: prevalence, clinical significance, and transmission. Sex Transm Infect. 2005;81:458-62 pubmed
    To study the prevalence, symptoms and signs of Mycoplasma genitalium and Chlamydia trachomatis infections in STD clinic attendees and in partners of M genitalium infected patients.
  56. Wikstrom A, Jensen J. Mycoplasma genitalium: a common cause of persistent urethritis among men treated with doxycycline. Sex Transm Infect. 2006;82:276-9 pubmed
    ..The aim of this study was to determine the importance of Mycoplasma genitalium in this condition and to monitor the effect of treatment with macrolides.
  57. Svenstrup H, Fedder J, Kristoffersen S, Trolle B, Birkelund S, Christiansen G. Mycoplasma genitalium, Chlamydia trachomatis, and tubal factor infertility--a prospective study. Fertil Steril. 2008;90:513-20 pubmed
    ..To determine the presence of M. genitalium and C. trachomatis in women attending fertility clinics and to follow these women for the effects of previous infections or tubal damage on pregnancy rate and outcome...
  58. Bradshaw C, Fairley C, Lister N, Chen S, Garland S, Tabrizi S. Mycoplasma genitalium in men who have sex with men at male-only saunas. Sex Transm Infect. 2009;85:432-5 pubmed publisher
    To determine the prevalence and clinical associations of Mycoplasma genitalium in urethral, rectal and pharyngeal specimens collected from men who have sex with men (MSM) attending male-only saunas.
  59. Waites K, Crabb D, Duffy L. Comparative in vitro susceptibilities of human mycoplasmas and ureaplasmas to a new investigational ketolide, CEM-101. Antimicrob Agents Chemother. 2009;53:2139-41 pubmed publisher
    ..telithromycin, doxycycline, levofloxacin, clindamycin, and linezolid against 36 Mycoplasma pneumoniae, 5 Mycoplasma genitalium, 13 Mycoplasma hominis, 15 Mycoplasma fermentans, and 20 Ureaplasma isolates...
  60. McGowin C, Radtke A, Abraham K, Martin D, Herbst Kralovetz M. Mycoplasma genitalium infection activates cellular host defense and inflammation pathways in a 3-dimensional human endocervical epithelial cell model. J Infect Dis. 2013;207:1857-68 pubmed publisher
    Because Mycoplasma genitalium is a prevalent and emerging cause of sexually transmitted infections, understanding the mechanisms by which M...
  61. Taylor Robinson D, Gilroy C, Thomas B, Hay P. Mycoplasma genitalium in chronic non-gonococcal urethritis. Int J STD AIDS. 2004;15:21-5 pubmed
    ..or recurrent non-gonococcal urethritis (NGU) at the time of referral, 11 (21%) were infected with Mycoplasma genitalium and three with Chlamydia trachomatis. Men who were M...
  62. Liu J, Yokota H, Kim R, Kim S. A conserved hypothetical protein from Mycoplasma genitalium shows structural homology to nusb proteins. Proteins. 2004;55:1082-6 pubmed
  63. Andersen B, Sokolowski I, Østergaard L, Kjølseth Møller J, Olesen F, Jensen J. Mycoplasma genitalium: prevalence and behavioural risk factors in the general population. Sex Transm Infect. 2007;83:237-41 pubmed
    b>Mycoplasma genitalium has been shown to cause urethritis in men and cervicitis in women and may also be a causative agent in female infertility.
  64. Haggerty C. Evidence for a role of Mycoplasma genitalium in pelvic inflammatory disease. Curr Opin Infect Dis. 2008;21:65-9 pubmed publisher
    b>Mycoplasma genitalium is a common sexually transmitted pathogen frequently identified among women with pelvic inflammatory disease, the infection and inflammation of a woman's upper genital tract...
  65. Francis S, Kent C, Klausner J, Rauch L, Kohn R, Hardick A, et al. Prevalence of rectal Trichomonas vaginalis and Mycoplasma genitalium in male patients at the San Francisco STD clinic, 2005-2006. Sex Transm Dis. 2008;35:797-800 pubmed publisher
  66. Gaydos C, Maldeis N, Hardick A, Hardick J, Quinn T. Mycoplasma genitalium compared to chlamydia, gonorrhoea and trichomonas as an aetiological agent of urethritis in men attending STD clinics. Sex Transm Infect. 2009;85:438-40 pubmed publisher
    To investigate prevalence of Mycoplasma genitalium, Chlamydia trachomatis, Neisseria gonorrhoeae and Trichomonas vaginalis in men, frequency of co-infections, and association of organisms with urethritis in men...
  67. Saikolappan S, Sasindran S, Yu H, Baseman J, Dhandayuthapani S. The Mycoplasma genitalium MG_454 gene product resists killing by organic hydroperoxides. J Bacteriol. 2009;191:6675-82 pubmed publisher
    b>Mycoplasma genitalium is the smallest self-replicating organism and a successful human pathogen associated with a range of genitourinary maladies...
  68. Haggerty C, Taylor B. Mycoplasma genitalium: an emerging cause of pelvic inflammatory disease. Infect Dis Obstet Gynecol. 2011;2011:959816 pubmed publisher
    b>Mycoplasma genitalium is a sexually transmitted pathogen that is increasingly identified among women with pelvic inflammatory disease (PID)...
  69. Yamaguchi Y, Takei M, Kishii R, Yasuda M, Deguchi T. Contribution of topoisomerase IV mutation to quinolone resistance in Mycoplasma genitalium. Antimicrob Agents Chemother. 2013;57:1772-6 pubmed publisher
    The mechanism of quinolone resistance in Mycoplasma genitalium remains poorly understood due to difficulties with in vitro culture, especially of clinical isolates...
  70. Ma L, Martin D. Single-nucleotide polymorphisms in the rRNA operon and variable numbers of tandem repeats in the lipoprotein gene among Mycoplasma genitalium strains from clinical specimens. J Clin Microbiol. 2004;42:4876-8 pubmed
    ..in the rRNA operon and variable numbers of tandem repeats in the lipoprotein gene MG309 among Mycoplasma genitalium strains from clinical specimens by PCR and sequencing. Analysis of 31 M...
  71. Musatovova O, Herrera C, Baseman J. Proximal region of the gene encoding cytadherence-related protein permits molecular typing of Mycoplasma genitalium clinical strains by PCR-restriction fragment length polymorphism. J Clin Microbiol. 2006;44:598-603 pubmed
    ..the gene encoding cytadherence accessory protein P110 (MG192) revealed DNA sequence divergences among 54 Mycoplasma genitalium clinical strains isolated from the genitourinary tracts of women attending a sexually transmitted disease-..
  72. Hjorth S, Björnelius E, Lidbrink P, Falk L, Dohn B, Berthelsen L, et al. Sequence-based typing of Mycoplasma genitalium reveals sexual transmission. J Clin Microbiol. 2006;44:2078-83 pubmed
    b>Mycoplasma genitalium causes male nonchlamydial, nongonococcal urethritis and is associated with cervicitis and pelvic inflammatory disease in women. Epidemiological studies indicate that M...
  73. Burgos R, Pich O, Ferrer Navarro M, Baseman J, Querol E, Piñol J. Mycoplasma genitalium P140 and P110 cytadhesins are reciprocally stabilized and required for cell adhesion and terminal-organelle development. J Bacteriol. 2006;188:8627-37 pubmed
    b>Mycoplasma genitalium is a human pathogen that mediates cell adhesion by a complex structure known as the attachment organelle...
  74. Arráiz R N, Colina Ch S, Marcucci J R, Rondón G N, Reyes S F, Bermúdez P V, et al. [Mycoplasma genitalium detection and correlation with clinical manifestations in population of the Zulia State, Venezuela]. Rev Chilena Infectol. 2008;25:256-61 pubmed publisher
    Diverse studies demonstrate an association between Mycoplasma genitalium and urogenital pathologies. The aim of this study was to investigate the prevalence of M...
  75. Olsen B, Lan P, Stålsby Lundborg C, Khang T, Unemo M. Population-based assessment of Mycoplasma genitalium in Vietnam--low prevalence among married women of reproductive age in a rural area. J Eur Acad Dermatol Venereol. 2009;23:533-7 pubmed publisher
    To analyse the prevalence of Mycoplasma genitalium infection in a population-based study among married women from a demographic surveillance site in a rural geographical area of Vietnam.
  76. Shimada Y, Deguchi T, Nakane K, Masue T, Yasuda M, Yokoi S, et al. Emergence of clinical strains of Mycoplasma genitalium harbouring alterations in ParC associated with fluoroquinolone resistance. Int J Antimicrob Agents. 2010;36:255-8 pubmed publisher
    Surveillance for antimicrobial resistance in Mycoplasma genitalium clinical strains is extremely limited as culturing of strains from clinical specimens is still difficult...
  77. Lalonde M, Zuo Y, Zhang J, Gong X, Wu S, Malhotra A, et al. Exoribonuclease R in Mycoplasma genitalium can carry out both RNA processing and degradative functions and is sensitive to RNA ribose methylation. RNA. 2007;13:1957-68 pubmed
    b>Mycoplasma genitalium, a small bacterium having minimal genome size, has only one identified exoribonuclease, RNase R (MgR)...
  78. Högdahl M, Kihlstrom E. Leucocyte esterase testing of first-voided urine and urethral and cervical smears to identify Mycoplasma genitalium-infected men and women. Int J STD AIDS. 2007;18:835-8 pubmed
    ..urine (FVU) and presence of leucocytes in urethral and cervical smears were evaluated to identify Mycoplasma genitalium infection in 416 men and 417 women attending Department of Genitourinary Medicine. M...
  79. Short V, Totten P, Ness R, Astete S, Kelsey S, Haggerty C. Clinical presentation of Mycoplasma genitalium Infection versus Neisseria gonorrhoeae infection among women with pelvic inflammatory disease. Clin Infect Dis. 2009;48:41-7 pubmed publisher
    ..The characteristics of nongonococcal, nonchlamydial PID have not been well described. Our objective was to examine the characteristics of Mycoplasma genitalium infection among women with clinically suspected PID.
  80. Short V, Totten P, Ness R, Astete S, Kelsey S, Murray P, et al. The demographic, sexual health and behavioural correlates of Mycoplasma genitalium infection among women with clinically suspected pelvic inflammatory disease. Sex Transm Infect. 2010;86:29-31 pubmed publisher
    b>Mycoplasma genitalium has been identified as a cause of pelvic inflammatory disease (PID), a clinical syndrome associated with inflammation of the female upper genital tract and serious reproductive sequelae...
  81. He J, You X, Zeng Y, Yu M, Zuo L, Wu Y. Mycoplasma genitalium-derived lipid-associated membrane proteins activate NF-kappaB through toll-like receptors 1, 2, and 6 and CD14 in a MyD88-dependent pathway. Clin Vaccine Immunol. 2009;16:1750-7 pubmed publisher
    b>Mycoplasma genitalium is a leading pathogen of nongonoccocal chlamydia-negative urethritis, which has been implicated directly in numerous other genitourinary and extragenitourinary tract pathologies...
  82. Ma L, Jensen J, Mancuso M, Hamasuna R, Jia Q, McGowin C, et al. Genetic variation in the complete MgPa operon and its repetitive chromosomal elements in clinical strains of Mycoplasma genitalium. PLoS ONE. 2010;5:e15660 pubmed publisher
    b>Mycoplasma genitalium has been increasingly recognized as an important microbe not only because of its significant association with human genital tract diseases but also because of its utility as a model for studying the minimum set of ..
  83. Rodrigues M, Fernandes P, Haddad J, Paiva M, Souza M, Andrade T, et al. Frequency of Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma genitalium, Mycoplasma hominis and Ureaplasma species in cervical samples. J Obstet Gynaecol. 2011;31:237-41 pubmed publisher
    We investigated the relative frequencies of Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma genitalium, Mycoplasma hominis and Ureaplasma sp. in cervical samples...
  84. Burgos R, Wood G, Young L, Glass J, Totten P. RecA mediates MgpB and MgpC phase and antigenic variation in Mycoplasma genitalium, but plays a minor role in DNA repair. Mol Microbiol. 2012;85:669-83 pubmed publisher
    b>Mycoplasma genitalium, a sexually transmitted human pathogen, encodes MgpB and MgpC adhesins that undergo phase and antigenic variation through recombination with archived 'MgPar' donor sequences...
  85. Yokoi S, Maeda S, Kubota Y, Tamaki M, Mizutani K, Yasuda M, et al. The role of Mycoplasma genitalium and Ureaplasma urealyticum biovar 2 in postgonococcal urethritis. Clin Infect Dis. 2007;45:866-71 pubmed
    ..Thus, we conducted a study to determine the prevalence of coinfection with genital mycoplasmas and ureaplasmas among men with GU and to assess the role of these pathogens in PGU...
  86. Napierala Mavedzenge S, Weiss H. Association of Mycoplasma genitalium and HIV infection: a systematic review and meta-analysis. AIDS. 2009;23:611-20 pubmed publisher
    To systematically review studies of Mycoplasma genitalium and the association with HIV infection in adults and to summarize the findings in a meta-analysis.
  87. Sluijter M, Aslam M, Hartwig N, van Rossum A, Vink C. Identification of amino acid residues critical for catalysis of Holliday junction resolution by Mycoplasma genitalium RecU. J Bacteriol. 2011;193:3941-8 pubmed publisher
    The RecU protein from Mycoplasma genitalium, RecU(Mge), is a 19...
  88. Ma L, Jensen J, Mancuso M, Hamasuna R, Jia Q, McGowin C, et al. Variability of trinucleotide tandem repeats in the MgPa operon and its repetitive chromosomal elements in Mycoplasma genitalium. J Med Microbiol. 2012;61:191-7 pubmed publisher
    b>Mycoplasma genitalium, a human pathogen associated with sexually transmitted diseases, is unique in that it has the smallest genome of any known free-living organism. Despite its small genome, 4...
  89. Johnston L, Paz Bailey G, Morales Miranda S, Morgan M, Alvarez B, Hickman L, et al. High prevalence of Mycoplasma genitalium among female sex workers in Honduras: implications for the spread of HIV and other sexually transmitted infections. Int J STD AIDS. 2012;23:5-11 pubmed publisher
    This study describes HIV, sexually transmitted infections (STI) and risk factors associated with Mycoplasma genitalium among female sex workers (FSWs) in four cities in Honduras...
  90. Jensen J. Protocol for the detection of Mycoplasma genitalium by PCR from clinical specimens and subsequent detection of macrolide resistance-mediating mutations in region V of the 23S rRNA gene. Methods Mol Biol. 2012;903:129-39 pubmed publisher
    b>Mycoplasma genitalium is an established cause of male nongonococcal urethritis, in particular in cases with recurrent disease and in those negative for Chlamydia trachomatis. In women M...
  91. Krieger J, Riley D. Chronic prostatitis: Charlottesville to Seattle. J Urol. 2004;172:2557-60 pubmed
    ..Since few men with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) have culturable bacteria by traditional approaches, we used sensitive molecular methods to determine presence of fastidious microorganisms...
  92. Ma L, Jensen J, Myers L, Burnett J, Welch M, Jia Q, et al. Mycoplasma genitalium: an efficient strategy to generate genetic variation from a minimal genome. Mol Microbiol. 2007;66:220-36 pubmed
    b>Mycoplasma genitalium, a human pathogen associated with sexually transmitted diseases, is unique in that it has smallest genome of any known free-living organism. The goal of this study was to investigate if and how M...