rickettsia

Summary

Summary: A genus of gram-negative, aerobic, rod-shaped bacteria often surrounded by a protein microcapsular layer and slime layer. The natural cycle of its organisms generally involves a vertebrate and an invertebrate host. Species of the genus are the etiological agents of human diseases, such as typhus.

Top Publications

  1. Dobec M, Golubic D, Punda Polic V, Kaeppeli F, Sievers M. Rickettsia helvetica in Dermacentor reticulatus ticks. Emerg Infect Dis. 2009;15:98-100 pubmed publisher
    We report on the molecular evidence that Dermacentor reticulatus ticks in Croatia are infected with Rickettsia helvetica (10%) or Rickettsia slovaca (2%) or co-infected with both species (1%)...
  2. Gillespie J, Williams K, Shukla M, Snyder E, Nordberg E, Ceraul S, et al. Rickettsia phylogenomics: unwinding the intricacies of obligate intracellular life. PLoS ONE. 2008;3:e2018 pubmed publisher
    Completed genome sequences are rapidly increasing for Rickettsia, obligate intracellular alpha-proteobacteria responsible for various human diseases, including epidemic typhus and Rocky Mountain spotted fever...
  3. Fournier P, El Karkouri K, Leroy Q, Robert C, Giumelli B, Renesto P, et al. Analysis of the Rickettsia africae genome reveals that virulence acquisition in Rickettsia species may be explained by genome reduction. BMC Genomics. 2009;10:166 pubmed publisher
    The Rickettsia genus includes 25 validated species, 17 of which are proven human pathogens. Among these, the pathogenicity varies greatly, from the highly virulent R...
  4. Zou Y, Wang Q, Fu Z, Liu P, Jin H, Yang H, et al. Detection of spotted fever group Rickettsia in Haemaphysalis longicornis from Hebei Province, China. J Parasitol. 2011;97:960-2 pubmed publisher
    ..Hebei Province, China, were analyzed by polymerase chain reaction (PCR) for the presence of spotted fever group Rickettsia. Fifty (6.9%) of 724 H. longicornis in the tick pool were positive, but no positive samples were found in 13 D...
  5. Silaghi C, Gilles J, Höhle M, Pradel I, Just F, Fingerle V, et al. Prevalence of spotted fever group rickettsiae in Ixodes ricinus (Acari: Ixodidae) in southern Germany. J Med Entomol. 2008;45:948-55 pubmed
    ..3%; 95% CI = 4.3-6.2%). Sequencing revealed Rickettsia helvetica in 91.4% of the samples and R. monacensis in 8.6%. Amplification of ompA was not possible for R...
  6. Boldis V, Strus J, Kocianova E, Tusek Znidaric M, Stefanidesová K, Schwarzová K, et al. Life cycle of Rickettsia slovaca in L929 cell line studied by quantitative real-time PCR and transmission electron microscopy. FEMS Microbiol Lett. 2009;293:102-6 pubmed publisher
    b>Rickettsia slovaca, a member of spotted fever rickettsiae, is an agent of a mild human disease known as Tibola or Debonel...
  7. Pluta S, Hartelt K, Oehme R, Mackenstedt U, Kimmig P. Prevalence of Coxiella burnetii and Rickettsia spp. in ticks and rodents in southern Germany. Ticks Tick Borne Dis. 2010;1:145-7 pubmed publisher
    Coxiella burnetii, the causative agent of Q fever, and Rickettsia spp. are bacterial pathogens that can be transmitted by ticks of the genus Dermacentor (i.e., Dermacentor marginatus and D. reticulatus)...
  8. Duan C, Tong Y, Huang Y, Wang X, Xiong X, Wen B. Complete genome sequence of Rickettsia heilongjiangensis, an emerging tick-transmitted human pathogen. J Bacteriol. 2011;193:5564-5 pubmed publisher
    b>Rickettsia heilongjiangensis is an emerging tick-transmitted human pathogen causing far-Eastern spotted fever. Here we report the complete sequence and the main features of the genome of R. heilongjiangensis (strain 054).
  9. Chiel E, Zchori Fein E, Inbar M, Gottlieb Y, Adachi Hagimori T, Kelly S, et al. Almost there: transmission routes of bacterial symbionts between trophic levels. PLoS ONE. 2009;4:e4767 pubmed publisher
    ..Here, we investigated transmission of two distantly related bacterial symbionts--Rickettsia and Hamiltonella--from their host, the sweet potato whitefly, Bemisia tabaci, to three species of whitefly ..

More Information

Publications105 found, 100 shown here

  1. Fortes F, Silveira I, Moraes Filho J, Leite R, Bonacim J, Biondo A, et al. Seroprevalence of Rickettsia bellii and Rickettsia felis in dogs, São José dos Pinhais, State of Paraná, Brazil. Rev Bras Parasitol Vet. 2010;19:222-7 pubmed
    Brazilian spotted fever (BSF) is a vector-borne zoonosis caused by Rickettsia rickettsii bacteria. Dogs can be host sentinels for this bacterium. The aim of the study was to determine the presence of antibodies against Rickettsia spp...
  2. Silva N, Eremeeva M, Rozental T, Ribeiro G, Paddock C, Ramos E, et al. Eschar-associated spotted fever rickettsiosis, Bahia, Brazil. Emerg Infect Dis. 2011;17:275-8 pubmed publisher
    ..The etiologic agent is most related to Rickettsia parkeri, R. africae, and R...
  3. Himler A, Adachi Hagimori T, Bergen J, Kozuch A, Kelly S, Tabashnik B, et al. Rapid spread of a bacterial symbiont in an invasive whitefly is driven by fitness benefits and female bias. Science. 2011;332:254-6 pubmed publisher
    ..Here, we show that Rickettsia sp. nr...
  4. Rieg S, Schmoldt S, Theilacker C, de With K, Wölfel S, Kern W, et al. Tick-borne lymphadenopathy (TIBOLA) acquired in Southwestern Germany. BMC Infect Dis. 2011;11:167 pubmed publisher
    Tick-borne lymphadenopathy (TIBOLA) was first described in 1997 in a patient in France. The causative agent, Rickettsia slovaca, is transmitted by Dermacentor ticks.
  5. Rymaszewska A, Piotrowski M. Use of DNA sequences for Rickettsia identification in Ixodes ricinus ticks: the first detection of Rickettsia monacensis in Poland. Microbes Infect. 2013;15:140-6 pubmed publisher
    ..tick Ixodes ricinus inhabiting Europe, including Poland, is a vector for many pathogens, such as various Rickettsia species, which spread to new territories...
  6. Sahni S, Rydkina E. Host-cell interactions with pathogenic Rickettsia species. Future Microbiol. 2009;4:323-39 pubmed publisher
    Pathogenic Rickettsia species are Gram-negative, obligate intracellular bacteria responsible for the spotted fever and typhus groups of diseases around the world...
  7. Dong X, El Karkouri K, Robert C, Raoult D, Fournier P. Genomic analysis of Rickettsia japonica strain YHT. J Bacteriol. 2012;194:6992 pubmed publisher
    b>Rickettsia japonica strain YH, isolated in 1984 in Japan, is the type strain of R. japonica, the tick-borne agent of Japanese spotted fever. Here, we report the 1.33-Mb genome of this rickettsial species.
  8. Wang J, Hudson B, Watts M, Karagiannis T, Fisher N, Anderson C, et al. Diagnosis of Queensland tick typhus and African tick bite fever by PCR of lesion swabs. Emerg Infect Dis. 2009;15:963-5 pubmed publisher
    ..We report 3 cases of Queensland tick typhus (QTT) and 1 case of African tick bite fever in which the causative rickettsiae were detected by PCR of eschar and skin lesions in all cases. An oral mucosal lesion in 1 QTT case was also positive...
  9. Graves S, Stenos J. Rickettsioses in Australia. Ann N Y Acad Sci. 2009;1166:151-5 pubmed publisher
    ..honei, strain "marmionii") in eastern Australia; Rickettsia felis, Western Australia; eight new RFG rickettsiae from ticks (of unknown pathogenicity); and two nonhuman ..
  10. Lledó L, Giménez Pardo C, Domínguez Peñafiel G, Sousa R, Gegúndez M, Casado N, et al. Molecular detection of hemoprotozoa and Rickettsia species in arthropods collected from wild animals in the Burgos Province, Spain. Vector Borne Zoonotic Dis. 2010;10:735-8 pubmed publisher
    ..In an attempt to address this issue, the prevalence of Theileria, Babesia, Hepatozoon, and Rickettsia species was investigated by polymerase chain reaction plus sequencing...
  11. Mediannikov O, Audoly G, Diatta G, Trape J, Raoult D. New Rickettsia sp. in tsetse flies from Senegal. Comp Immunol Microbiol Infect Dis. 2012;35:145-50 pubmed publisher
    ..In all studied flies we amplified genes of bacterium phylogenetically close to obligate intracellular pathogen Rickettsia felis, the agent of spotted fever in humans...
  12. Duron O. Lateral transfers of insertion sequences between Wolbachia, Cardinium and Rickettsia bacterial endosymbionts. Heredity (Edinb). 2013;111:330-7 pubmed publisher
    ..that a selfish genetic element, the insertion sequence ISRpe1, is widespread in the Wolbachia, Cardinium and Rickettsia endosymbionts and experiences recent (and likely ongoing) transfers over long evolutionary distances...
  13. Nava S, Elshenawy Y, Eremeeva M, Sumner J, Mastropaolo M, Paddock C. Rickettsia parkeri in Argentina. Emerg Infect Dis. 2008;14:1894-7 pubmed publisher
    ..When evaluated by PCR, 17 (7.6%) of 223 questing adult A. triste ticks, collected from 2 sites in the lower Paraná River Delta, contained DNA of Rickettsia parkeri.
  14. Strube C, Schicht S, Schnieder T. Borrelia burgdorferi sensu lato and Rickettsia spp. infections in hard ticks (Ixodes ricinus) in the region of Hanover (Germany). Berl Munch Tierarztl Wochenschr. 2011;124:512-7 pubmed
    ..garinii, B. spielmanii, B. valaisiana and B. burgdorferi sensu stricto (ss). Rickettsia spp. were found in 34.2% of the collected ticks, divided into 37.6% adults (42.5% females and 32...
  15. Oteo J, Portillo A. Tick-borne rickettsioses in Europe. Ticks Tick Borne Dis. 2012;3:271-8 pubmed publisher
    Rickettsioses are caused by obligate intracellular bacteria within the genus Rickettsia, mainly transmitted by arthropods...
  16. Cicuttin G, Nava S. Molecular identification of Rickettsia parkeri infecting Amblyomma triste ticks in an area of Argentina where cases of rickettsiosis were diagnosed. Mem Inst Oswaldo Cruz. 2013;108:123-5 pubmed
    Specimens of the hard tick Amblyomma triste were found infected with Rickettsia parkeri in an area of Argentina (General Lavalle, Buenos Aires Province) where cases of human illness attributed to this microorganism have been reported...
  17. Dergousoff S, Gajadhar A, Chilton N. Prevalence of Rickettsia species in Canadian populations of Dermacentor andersoni and D. variabilis. Appl Environ Microbiol. 2009;75:1786-9 pubmed publisher
    We determined the prevalence of rickettsiae in Dermacentor adults at 15 localities in Canada. Rickettsia rickettsii was not detected in any tick, whereas Rickettsia peacockii was present in 76% of Dermacentor andersoni adults and ..
  18. Weinert L, Welch J, Jiggins F. Conjugation genes are common throughout the genus Rickettsia and are transmitted horizontally. Proc Biol Sci. 2009;276:3619-27 pubmed publisher
    b>Rickettsia are endosymbionts of arthropods, some of which are vectored to vertebrates where they cause disease...
  19. Elfving K, Olsen B, Bergstrom S, Waldenstrom J, Lundkvist A, Sjostedt A, et al. Dissemination of spotted fever rickettsia agents in Europe by migrating birds. PLoS ONE. 2010;5:e8572 pubmed publisher
    ..The DNA was assayed for detection of Rickettsia spp. using real-time PCR, followed by DNA sequencing for species identification. Rickettsia spp...
  20. Szabo M, Nieri Bastos F, Spolidorio M, Martins T, Barbieri A, Labruna M. In vitro isolation from Amblyomma ovale (Acari: Ixodidae) and ecological aspects of the Atlantic rainforest Rickettsia, the causative agent of a novel spotted fever rickettsiosis in Brazil. Parasitology. 2013;140:719-28 pubmed publisher
    ..A Rickettsia parkeri-like agent (Rickettsia sp...
  21. Johnston S, Glaser C, Padgett K, Wadford D, Espinosa A, Espinosa N, et al. Rickettsia spp. 364D causing a cluster of eschar-associated illness, California. Pediatr Infect Dis J. 2013;32:1036-9 pubmed publisher
    We describe the clinical course of the first 3 pediatric cases infected with Rickettsia spp. 364D. Although the pathogen was identified in California ticks decades ago, only recently have human cases been documented...
  22. Balraj P, Nappez C, Raoult D, Renesto P. Western-blot detection of RickA within spotted fever group rickettsiae using a specific monoclonal antibody. FEMS Microbiol Lett. 2008;286:257-62 pubmed publisher
    ..Here, using recombinant protein of Rickettsia conorii as an antigen, we produced a monoclonal antibody (mAb) directed against RickA...
  23. Bayliss D, Morris A, Horta M, Labruna M, Radecki S, Hawley J, et al. Prevalence of Rickettsia species antibodies and Rickettsia species DNA in the blood of cats with and without fever. J Feline Med Surg. 2009;11:266-70 pubmed publisher
    b>Rickettsia species antibodies have been detected in some cats but it is unknown whether infected cats develop clinical signs...
  24. Felsheim R, Kurtti T, Munderloh U. Genome sequence of the endosymbiont Rickettsia peacockii and comparison with virulent Rickettsia rickettsii: identification of virulence factors. PLoS ONE. 2009;4:e8361 pubmed publisher
    b>Rickettsia peacockii, also known as the East Side Agent, is a non-pathogenic obligate intracellular bacterium found as an endosymbiont in Dermacentor andersoni ticks in the western USA and Canada...
  25. Kuo C, Huang J, Lin T, Wang H. Detection of Rickettsia spp. and host and habitat associations of fleas (Siphonaptera) in eastern Taiwan. Med Vet Entomol. 2012;26:341-50 pubmed publisher
    b>Rickettsia typhi and Rickettsia felis (Rickettsiales: Rickettsiaceae) are two rickettsiae principally transmitted by fleas, but the detection of either pathogen has rarely been attempted in Taiwan...
  26. Robinson J, Eremeeva M, Olson P, Thornton S, Medina M, Sumner J, et al. New approaches to detection and identification of Rickettsia africae and Ehrlichia ruminantium in Amblyomma variegatum (Acari: Ixodidae) ticks from the Caribbean. J Med Entomol. 2009;46:942-51 pubmed
    ..A. variegatum is a vector for Rickettsia africae, the causative agent of African tick bite fever, and Ehrlichia ruminantium, the causative agent of ..
  27. Burri C, Dupasquier C, Bastic V, Gern L. Pathogens of emerging tick-borne diseases, Anaplasma phagocytophilum, Rickettsia spp., and Babesia spp., in ixodes ticks collected from rodents at four sites in Switzerland (Canton of Bern). Vector Borne Zoonotic Dis. 2011;11:939-44 pubmed publisher
    ..Here we focused on the detection of three intracellular pathogens, Anaplasma phagocytophilum, Rickettsia spp., and Babesia spp., in field-derived ticks that detached from 79 small mammals...
  28. Goodacre S, Martin O, Bonte D, Hutchings L, Woolley C, Ibrahim K, et al. Microbial modification of host long-distance dispersal capacity. BMC Biol. 2009;7:32 pubmed publisher
    ..This spider persists in heterogeneous environments because of its ability to recolonise areas through active long-distance airborne dispersal using silk as a sail, in a process termed 'ballooning'...
  29. Duh D, Punda Polic V, Avsic Zupanc T, Bouyer D, Walker D, Popov V, et al. Rickettsia hoogstraalii sp. nov., isolated from hard- and soft-bodied ticks. Int J Syst Evol Microbiol. 2010;60:977-84 pubmed publisher
    A novel spotted fever group Rickettsia was found in Haemaphysalis sulcata ticks collected from sheep and goats in Croatia in 2006...
  30. Conti Diaz I, Moraes Filho J, Pacheco R, Labruna M. Serological evidence of Rickettsia parkeri as the etiological agent of rickettsiosis in Uruguay. Rev Inst Med Trop Sao Paulo. 2009;51:337-9 pubmed
    ..The three clinical cases presented clinical manifestations similar to previous reported cases of Rickettsia parkeri in the United States; that is mild fever (< 40 degrees C), malaise, headache, rash, inoculation ..
  31. Franke J, Fritzsch J, Tomaso H, Straube E, Dorn W, Hildebrandt A. Coexistence of pathogens in host-seeking and feeding ticks within a single natural habitat in Central Germany. Appl Environ Microbiol. 2010;76:6829-36 pubmed publisher
    ..Our results suggest that birds not only are important reservoirs for several pathogens but also act as vehicles for infected ticks and might therefore play a key role in the dispersal of tick-borne diseases...
  32. Uchiyama T, Kishi M, Ogawa M. Restriction of the growth of a nonpathogenic spotted fever group rickettsia. FEMS Immunol Med Microbiol. 2012;64:42-7 pubmed publisher
    ..Vero and HeLa cells derived from mammals were inoculated with a nonpathogenic species of spotted fever group rickettsia, Rickettsia montanensis, before being infected with the pathogenic species Rickettsia japonica...
  33. Giulieri S, Jaton K, Cometta A, Trellu L, Greub G. Development of a duplex real-time PCR for the detection of Rickettsia spp. and typhus group rickettsia in clinical samples. FEMS Immunol Med Microbiol. 2012;64:92-7 pubmed publisher
    ..a duplex real-time PCR that amplifies (1) DNA of any rickettsial species and (2) DNA of both typhus group rickettsia, that is, Rickettsia prowazekii and Rickettsia typhi...
  34. Wallménius K, Pettersson J, Jaenson T, Nilsson K. Prevalence of Rickettsia spp., Anaplasma phagocytophilum, and Coxiella burnetii in adult Ixodes ricinus ticks from 29 study areas in central and southern Sweden. Ticks Tick Borne Dis. 2012;3:100-6 pubmed publisher
    ..adult Ixodes ricinus ticks (469 females and 418 males) from 29 different localities in Sweden were screened for Rickettsia, Anaplasma, and Coxiella DNA using PCR and then subjected to gene sequencing. Rickettsial DNA was detected in 9...
  35. Mao C, Bhardwaj K, Sharkady S, Fish R, Driscoll T, Wower J, et al. Variations on the tmRNA gene. RNA Biol. 2009;6:355-61 pubmed
  36. Ando S, Kurosawa M, Sakata A, Fujita H, Sakai K, Sekine M, et al. Human Rickettsia heilongjiangensis infection, Japan. Emerg Infect Dis. 2010;16:1306-8 pubmed publisher
    A case of Rickettsia heilongjiangensis infection in Japan was identified in a 35-year-old man who had rash, fever, and eschars. Serum contained R. heilongjiangensis antibodies, and eschars contained R. heilongjiangensis DNA. R...
  37. Tabara K, Kawabata H, Arai S, Itagaki A, Yamauchi T, Katayama T, et al. High incidence of rickettsiosis correlated to prevalence of Rickettsia japonica among Haemaphysalis longicornis tick. J Vet Med Sci. 2011;73:507-10 pubmed
    ..cases found in the endemic area, the infectious agent of spotted fever group rickettsiosis was identified as Rickettsia japonica...
  38. Richards A. Worldwide detection and identification of new and old rickettsiae and rickettsial diseases. FEMS Immunol Med Microbiol. 2012;64:107-10 pubmed publisher
    ..These methods have lead to the detection of new and old rickettsial pathogens often in new locations leading investigators to suggest new regions of risk of these rickettsioses...
  39. Palomar A, Portillo A, Santibáñez P, Santibáñez S, García Álvarez L, Oteo J. Genetic characterization of Candidatus Rickettsia vini, a new rickettsia amplified in ticks from La Rioja, Spain. Ticks Tick Borne Dis. 2012;3:319-21 pubmed publisher
    A total of 222 ticks removed from birds in La Rioja (Spain) were screened for spotted fever group rickettsia species using ompA PCR assays. Rickettsia monacensis (n=1) and R. sibirica (n=1) were detected...
  40. Kernif T, Djerbouh A, Mediannikov O, Ayach B, Rolain J, Raoult D, et al. Rickettsia africae in Hyalomma dromedarii ticks from sub-Saharan Algeria. Ticks Tick Borne Dis. 2012;3:377-9 pubmed publisher
    Spotted fever group (SFG) rickettsioses are caused by obligate, intracellular Gram-negative bacteria of the genus Rickettsia. In recent years, several species and subspecies of rickettsias have been identified as emerging pathogens ..
  41. Vilcins I, Fournier P, Old J, Deane E. Evidence for the presence of Francisella and spotted fever group rickettsia DNA in the tick Amblyomma fimbriatum (Acari: Ixodidae), Northern Territory, Australia. J Med Entomol. 2009;46:926-33 pubmed
    ..ticks per pool), according to sex or host animal, resulted in 187 samples used for screening for the presence of Rickettsia species via molecular methods...
  42. Veronez V, Freitas B, Olegário M, Carvalho W, Pascoli G, Thorga K, et al. Ticks (Acari: Ixodidae) within various phytophysiognomies of a Cerrado reserve in Uberlândia, Minas Gerais, Brazil. Exp Appl Acarol. 2010;50:169-79 pubmed publisher
    ..Search for Rickettsia in the hemolymph of 497 A. cajennense and one A. dubitatum ticks yielded negative results...
  43. Tomassone L, Nunez P, Ceballos L, Gurtler R, Kitron U, Farber M. Detection of "Candidatus Rickettsia sp. strain Argentina"and Rickettsia bellii in Amblyomma ticks (Acari: Ixodidae) from Northern Argentina. Exp Appl Acarol. 2010;52:93-100 pubmed publisher
    ..adult ticks, identified as Amblyomma parvum, Amblyomma tigrinum and Amblyomma pseudoconcolor, was examined for Rickettsia spp. We identified an SFG rickettsia of unknown pathogenicity, "Candidatus Rickettsia sp...
  44. Heise S, Elshahed M, Little S. Bacterial diversity in Amblyomma americanum (Acari: Ixodidae) with a focus on members of the genus Rickettsia. J Med Entomol. 2010;47:258-68 pubmed
    ..In contrast, the proportion of OTUs identified as Rickettsia sp. in wild-caught ticks increased from 2.2% (2/92) before feeding to as high as 46...
  45. Phan J, Lu C, Bender W, Smoak R, Zhong J. Molecular detection and identification of Rickettsia species in Ixodes pacificus in California. Vector Borne Zoonotic Dis. 2011;11:957-61 pubmed publisher
    ..Sequencing, BLAST analysis, and phylogenetic constructions indicated that two Rickettsia phylotypes are present in I. pacificus...
  46. Abarca K, Lopez J, Acosta Jamett G, Lepe P, Soares J, Labruna M. A third Amblyomma species and the first tick-borne rickettsia in Chile. J Med Entomol. 2012;49:219-22 pubmed
    ..triste. Molecular analyses also showed that one of the three Chilean ticks was infected by Candidatus 'Rickettsia andeanae'. These findings extend the geographical distribution of A...
  47. Matsutani M, Ogawa M, Takaoka N, Hanaoka N, Toh H, Yamashita A, et al. Complete genomic DNA sequence of the East Asian spotted fever disease agent Rickettsia japonica. PLoS ONE. 2013;8:e71861 pubmed publisher
    b>Rickettsia japonica is an obligate intracellular alphaproteobacteria that causes tick-borne Japanese spotted fever, which has spread throughout East Asia. We determined the complete genomic DNA sequence of R...
  48. Izzard L, Graves S, Cox E, Fenwick S, Unsworth N, Stenos J. Novel rickettsia in ticks, Tasmania, Australia. Emerg Infect Dis. 2009;15:1654-6 pubmed publisher
    A novel rickettsia was detected in Ixodes tasmani ticks collected from Tasmanian devils. A total of 55% were positive for the citrate synthase gene by quantitative PCR...
  49. Williamson P, Billingsley P, Teltow G, Seals J, Turnbough M, Atkinson S. Borrelia, Ehrlichia, and Rickettsia spp. in ticks removed from persons, Texas, USA. Emerg Infect Dis. 2010;16:441-6 pubmed publisher
    ..Cause, treatment, and prevention strategies can be better addressed through collecting sufficient data to establish baseline assessments of risk...
  50. Serio A, Jeng R, Haglund C, Reed S, Welch M. Defining a core set of actin cytoskeletal proteins critical for actin-based motility of Rickettsia. Cell Host Microbe. 2010;7:388-98 pubmed publisher
    Many Rickettsia species are intracellular bacterial pathogens that use actin-based motility for spread during infection...
  51. Wieten R, Hovius J, Groen E, van der Wal A, de Vries P, Beersma M, et al. Molecular diagnostics of Rickettsia africae infection in travelers returning from South Africa to The Netherlands. Vector Borne Zoonotic Dis. 2011;11:1541-7 pubmed publisher
    ..It is caused by Rickettsia africae and diagnosis is based on travel history and clinical presentation and usually confirmed by detecting ..
  52. Nilsson K. Septicaemia with Rickettsia helvetica in a patient with acute febrile illness, rash and myasthenia. J Infect. 2009;58:79-82 pubmed publisher
    The spotted fever rickettsia, Rickettsia helvetica, is mostly reported to present a flu-like self-limiting disease. In the present case, however, where the presence of R...
  53. Boretti F, Perreten A, Meli M, Cattori V, Willi B, Wengi N, et al. Molecular Investigations of Rickettsia helvetica infection in dogs, foxes, humans, and Ixodes ticks. Appl Environ Microbiol. 2009;75:3230-7 pubmed publisher
    b>Rickettsia helvetica, a tick-borne member of the spotted-fever-group rickettsiae, is a suspected pathogen in humans; however, its role in animals is unknown. The aims of this study were to establish a R...
  54. Fournier P, Raoult D. Current knowledge on phylogeny and taxonomy of Rickettsia spp. Ann N Y Acad Sci. 2009;1166:1-11 pubmed publisher
    Due to improved diagnostic methods and increased interest, the number of representatives of the genus Rickettsia has increased dramatically over the past 20 years, with 25 currently validated species...
  55. Parola P, Rovery C, Rolain J, Brouqui P, Davoust B, Raoult D. Rickettsia slovaca and R. raoultii in tick-borne Rickettsioses. Emerg Infect Dis. 2009;15:1105-8 pubmed publisher
    ..We identified the etiologic agent for 65% of 86 patients with TIBOLA/DEBONEL as either Rickettsia slovaca (49/86, 57%) or R. raoultii (7/86, 8%).
  56. Varela Stokes A, Paddock C, Engber B, Toliver M. Rickettsia parkeri in Amblyomma maculatum ticks, North Carolina, USA, 2009-2010. Emerg Infect Dis. 2011;17:2350-3 pubmed publisher
    We detected Rickettsia parkeri in 20%-33% of Amblyomma maculatum ticks sampled in North Carolina. Results highlight the high frequencies of R...
  57. Tian Z, Liu G, Shen H, Xie J, Luo J, Tian M. First report on the occurrence of Rickettsia slovaca and Rickettsia raoultii in Dermacentor silvarum in China. Parasit Vectors. 2012;5:19 pubmed publisher
    ..Although new spotted fever group rickettsiae have been isolated in many parts of the world including China, Little is known about the epidemiology of Rickettsia pathogens in ticks from Xinjiang Autonomous Region of China.
  58. Weinert L, Werren J, Aebi A, Stone G, Jiggins F. Evolution and diversity of Rickettsia bacteria. BMC Biol. 2009;7:6 pubmed publisher
    b>Rickettsia are intracellular symbionts of eukaryotes that are best known for infecting and causing serious diseases in humans and other mammals...
  59. Pornwiroon W, Bourchookarn A, Paddock C, Macaluso K. Proteomic analysis of Rickettsia parkeri strain portsmouth. Infect Immun. 2009;77:5262-71 pubmed publisher
    b>Rickettsia parkeri, a recently recognized pathogen of human, is one of several Rickettsia spp. in the United States that causes a spotted fever rickettsiosis...
  60. Tomassone L, Conte V, Parrilla G, De Meneghi D. Rickettsia infection in dogs and Rickettsia parkeri in Amblyomma tigrinum ticks, Cochabamba Department, Bolivia. Vector Borne Zoonotic Dis. 2010;10:953-8 pubmed publisher
    ..Dog sera were subjected to enzyme-linked immunosorbent assay test to detect IgG antibodies against Rickettsia rickettsii and 68.2% of samples were found to be positive (n?=?30; 95% confidence interval [CI]: 52.4-81.4)...
  61. Schorn S, Pfister K, Reulen H, Mahling M, Silaghi C. Occurrence of Babesia spp., Rickettsia spp. and Bartonella spp. in Ixodes ricinus in Bavarian public parks, Germany. Parasit Vectors. 2011;4:135 pubmed publisher
    ..b>Rickettsia spp. and Bartonella spp. by PCR...
  62. Bowman D. Introduction to the alpha-proteobacteria: Wolbachia and Bartonella, Rickettsia, Brucella, Ehrlichia, and Anaplasma. Top Companion Anim Med. 2011;26:173-7 pubmed publisher
    ..and this group includes a number of important arthropod-transmitted bacterial agents of dogs and cats: Rickettsia rickettsii, R. felis, Anaplasma platys, Ehrlichia canis, E. chaffeensis, and E. ewingii...
  63. Masala G, Chisu V, Satta G, Socolovschi C, Raoult D, Parola P. Rickettsia slovaca from Dermacentor marginatus ticks in Sardinia, Italy. Ticks Tick Borne Dis. 2012;3:393-5 pubmed publisher
    ..gltA-specific and ompA-specific primers, leading to the identification and first isolation in cell culture of Rickettsia slovaca, the causative agent of tick-borne lymphadenopathy (TIBOLA), on the island of Sardinia...
  64. Nilsson K, Elfving K, Pahlson C. Rickettsia helvetica in patient with meningitis, Sweden, 2006. Emerg Infect Dis. 2010;16:490-2 pubmed publisher
    Pathogenicity of Rickettsia helvetica is relatively unknown. We isolated a spotted fever group rickettsial organism from a patient with subacute meningitis...
  65. Spolidorio M, Labruna M, Mantovani E, Brandao P, Richtzenhain L, Yoshinari N. Novel spotted fever group rickettsiosis, Brazil. Emerg Infect Dis. 2010;16:521-3 pubmed publisher
    ..Molecular analysis of skin samples indicated the agent was a novel spotted fever group strain closely related to Rickettsia africae, R. parkeri, and R. sibirica.
  66. Haglund C, Choe J, Skau C, Kovar D, Welch M. Rickettsia Sca2 is a bacterial formin-like mediator of actin-based motility. Nat Cell Biol. 2010;12:1057-63 pubmed publisher
    ..b>Rickettsia in the spotted fever group (SFG) are Gram-negative, obligate intracellular bacterial pathogens that undergo ..
  67. Ogrzewalska M, Uezu A, Jenkins C, Labruna M. Effect of forest fragmentation on tick infestations of birds and tick infection rates by rickettsia in the Atlantic forest of Brazil. Ecohealth. 2011;8:320-31 pubmed publisher
    ..nodosum tested for rickettsial infection by polymerase chain reaction, 51 were found to be infected by Rickettsia bellii or Rickettsia parkeri. However, tick infection rates by Rickettsia spp...
  68. Kato C, Chung I, Robinson L, Austin A, Dasch G, Massung R. Assessment of real-time PCR assay for detection of Rickettsia spp. and Rickettsia rickettsii in banked clinical samples. J Clin Microbiol. 2013;51:314-7 pubmed publisher
    Two novel real-time PCR assays were developed for the detection of Rickettsia spp. One assay detects all tested Rickettsia spp.; the other is specific for Rickettsia rickettsii...
  69. Socolovschi C, Kernif T, Raoult D, Parola P. Borrelia, Rickettsia, and Ehrlichia species in bat ticks, France, 2010. Emerg Infect Dis. 2012;18:1966-75 pubmed publisher
    ..b>Rickettsia sp. AvBat, a new genotype of spotted fever group rickettsiae, was detected and cultivated from 3 of the 5 ticks...
  70. Qi Y, Xiong X, Duan C, Jiao J, Gong W, Wen B. Recombinant protein YbgF induces protective immunity against Rickettsia heilongjiangensis infection in C3H/HeN mice. Vaccine. 2013;31:5643-50 pubmed publisher
    Surface proteins YbgF and PrsA are major seroreactive antigens of Rickettsia heilongjiangensis, the etiological agent of Far-Eastern spotted fever. This study investigated their potential immunogenicity for protective immunity.
  71. Márquez F. Spotted fever group Rickettsia in ticks from southeastern Spain natural parks. Exp Appl Acarol. 2008;45:185-94 pubmed publisher
    ..pusillus) only R. massiliae (15.2%) was found. Haemaphysalis punctata and Ha. sulcata were infected with a Rickettsia sp. near R. hoogstraalii (prevalence of 3.1% and 16.1%, respectively). In addition, Ha...
  72. Boldis V, Spitalska E. Dermacentor marginatus and Ixodes ricinus ticks versus L929 and Vero cell lines in Rickettsia slovaca life cycle evaluated by quantitative real time PCR. Exp Appl Acarol. 2010;50:353-9 pubmed publisher
    Ticks transmit many different pathogens to animals, humans and their pets. Rickettsia slovaca, as a member of the spotted-fever-group rickettsiae is an agent of the human disease Tick-borne lymphadenopathy (TIBOLA), also called ..
  73. Premaratna R, Rajapakse R, Chandrasena T, Nanayakkara D, Bandara N, Kularatna S, et al. Contribution of rickettsioses in Sri Lankan patients with fever who responded to empirical doxycycline treatment. Trans R Soc Trop Med Hyg. 2010;104:368-70 pubmed publisher
    ..This suggests that greater use of doxycycline appears justified for patients with undiagnosed fever in settings where rickettsial diseases are endemic or re-emerging with inadequate diagnostic facilities...
  74. Milhano N, de Carvalho I, Alves A, Arroube S, Soares J, Rodriguez P, et al. Coinfections of Rickettsia slovaca and Rickettsia helvetica with Borrelia lusitaniae in ticks collected in a Safari Park, Portugal. Ticks Tick Borne Dis. 2010;1:172-7 pubmed publisher
    Borrelia and Rickettsia bacteria are the most important tick-borne agents causing disease in Portugal...
  75. Park H, Lee J, Gouin E, Cossart P, Izard T. The rickettsia surface cell antigen 4 applies mimicry to bind to and activate vinculin. J Biol Chem. 2011;286:35096-103 pubmed publisher
    Pathogenic Rickettsia species cause high morbidity and mortality, especially R. prowazekii, the causative agent of typhus. Like many intracellular pathogens, Rickettsia exploit the cytoskeleton to enter and spread within the host cell...
  76. Fornadel C, Zhang X, Smith J, Paddock C, Arias J, Norris D. High rates of Rickettsia parkeri infection in Gulf Coast ticks (Amblyomma maculatum) and identification of "Candidatus Rickettsia andeanae" from Fairfax County, Virginia. Vector Borne Zoonotic Dis. 2011;11:1535-9 pubmed publisher
    The Gulf Coast tick, Amblyomma maculatum, is a vector of Rickettsia parkeri, a recently identified human pathogen that causes a disease with clinical symptoms that resemble a mild form of Rocky Mountain spotted fever...
  77. Roucher C, Mediannikov O, Diatta G, Trape J, Raoult D. A new Rickettsia species found in fleas collected from human dwellings and from domestic cats and dogs in Senegal. Vector Borne Zoonotic Dis. 2012;12:360-5 pubmed publisher
    ..4% of acute febrile diseases in the Sine-Saloum region of Senegal were due to Rickettsia felis. The aim of this study was to explain the high prevalence of R...
  78. Fournier P, El Karkouri K, Robert C, Medigue C, Raoult D. Complete genome sequence of Rickettsia slovaca, the agent of tick-borne lymphadenitis. J Bacteriol. 2012;194:1612 pubmed publisher
    The present study reports the complete and annotated genome sequence of the human pathogen Rickettsia slovaca strain 13-B, which was isolated from a Dermacentor tick in Slovakia in 1968. The 1...
  79. Ogrzewalska M, Literak I, Cardenas Callirgos J, Capek M, Labruna M. Rickettsia bellii in ticks Amblyomma varium Koch, 1844, from birds in Peru. Ticks Tick Borne Dis. 2012;3:254-6 pubmed publisher
    ..calcaratum Neumann, 1899. The 2 larvae of A. varium were infected with Rickettsia bellii. This is the first report of R. bellii in A. varium and also the first record of this rickettsia in Peru...
  80. Dubska L, Literak I, Kverek P, Roubalova E, Kocianova E, Taragelova V. Tick-borne zoonotic pathogens in ticks feeding on the common nightingale including a novel strain of Rickettsia sp. Ticks Tick Borne Dis. 2012;3:265-8 pubmed publisher
    ..sampled in the Czech Republic in 2008 for the presence of Borrelia spirochetes, Anaplasma phagocytophilum, Rickettsia spp., and Babesia spp. We detected Borrelia garinii (in 4% of ticks), A...
  81. Tijsse Klasen E, Sprong H, Pandak N. Co-infection of Borrelia burgdorferi sensu lato and Rickettsia species in ticks and in an erythema migrans patient. Parasit Vectors. 2013;6:347 pubmed publisher
    ..Here, we compared the exposure to Rickettsia helvetica and Rickettsia monacensis with that to Lyme borreliosis spirochetes...
  82. Cohen S, Yabsley M, Garrison L, Freye J, Dunlap B, Dunn J, et al. Rickettsia parkeri in Amblyomma americanum ticks, Tennessee and Georgia, USA. Emerg Infect Dis. 2009;15:1471-3 pubmed publisher
    To determine the geographic distribution of the newly recognized human pathogen Rickettsia parkeri, we looked for this organism in ticks from Tennessee and Georgia, USA. Using PCR and sequence analysis, we identified R...
  83. Baldridge G, Burkhardt N, Oliva A, Kurtti T, Munderloh U. Rickettsial ompB promoter regulated expression of GFPuv in transformed Rickettsia montanensis. PLoS ONE. 2010;5:e8965 pubmed publisher
    b>Rickettsia spp. (Rickettsiales: Rickettsiaceae) are Gram-negative, obligate intracellular, alpha-proteobacteria that have historically been associated with blood-feeding arthropods...
  84. Edwards K, Goddard J, Jones T, Paddock C, Varela Stokes A. Cattle and the natural history of Rickettsia parkeri in Mississippi. Vector Borne Zoonotic Dis. 2011;11:485-91 pubmed publisher
    ..For nearly as long, A. maculatum have been known to harbor the spotted fever group Rickettsia (SFGR), now known as Rickettsia parkeri. However, human infection with R. parkeri was not documented until 2004...
  85. Sabatini G, Pinter A, Nieri Bastos F, Marcili A, Labruna M. Survey of ticks (Acari: Ixodidae) and their rickettsia in an Atlantic rain forest reserve in the State of São Paulo, Brazil. J Med Entomol. 2010;47:913-6 pubmed
    ..b>Rickettsia bellii, a rickettsia of unknown pathogenicity, was detected in one A. aureolatum, one A. ovale, and three A...
  86. Kelly P, Lucas H, Beati L, Yowell C, Mahan S, Dame J. Rickettsia africae in Amblyomma variegatum and domestic ruminants on eight Caribbean islands. J Parasitol. 2010;96:1086-8 pubmed publisher
    ..Kitts (7), American Virgin Islands (4), Montserrat (2), and St. Lucia (1) were 100% homologous with that of Rickettsia africae , the agent of African tick-bite fever. To determine if transmission of R...
  87. Toju H, Fukatsu T. Diversity and infection prevalence of endosymbionts in natural populations of the chestnut weevil: relevance of local climate and host plants. Mol Ecol. 2011;20:853-68 pubmed publisher
    ..we identified six distinct endosymbiont lineages, namely Curculioniphilus, Sodalis, Serratia, Wolbachia, Rickettsia and Spiroplasma, at different infection frequencies (96.7%, 12.8%, 82.3%, 82.5%, 28.2% and 6...
  88. Chu D, Gao C, De Barro P, Zhang Y, Wan F, Khan I. Further insights into the strange role of bacterial endosymbionts in whitefly, Bemisia tabaci: comparison of secondary symbionts from biotypes B and Q in China. Bull Entomol Res. 2011;101:477-86 pubmed publisher
    The percentage infection of secondary symbionts (SS) (Wolbachia, Arsenophonus, Rickettsia, Hamiltonella, Fritschea and Cardinium) in the exotic Bemisia tabaci (Genn...
  89. Hun L, Troyo A, Taylor L, Barbieri A, Labruna M. First report of the isolation and molecular characterization of Rickettsia amblyommii and Rickettsia felis in Central America. Vector Borne Zoonotic Dis. 2011;11:1395-7 pubmed publisher
    ..The three tick isolates were genotypically identified as Rickettsia amblyommii, and the flea isolate was identified as Rickettsia felis through DNA sequencing of portions of the ..
  90. Reed S, Serio A, Welch M. Rickettsia parkeri invasion of diverse host cells involves an Arp2/3 complex, WAVE complex and Rho-family GTPase-dependent pathway. Cell Microbiol. 2012;14:529-45 pubmed publisher
    ..To identify the host factors important during cell invasion by Rickettsia parkeri, a member of the spotted fever group (SFG), we performed an RNAi screen targeting 105 proteins in ..
  91. Schicht S, Schnieder T, Strube C. Rickettsia spp. and coinfections with other pathogenic microorganisms in hard ticks from northern Germany. J Med Entomol. 2012;49:766-71 pubmed
    b>Rickettsia species are the causative agent of different forms of spotted fever and thus, monitored in a number of prevalence studies...
  92. Goddard J, Varela Stokes A, Smith W, Edwards K. Artificial infection of the bed bug with Rickettsia parkeri. J Med Entomol. 2012;49:922-6 pubmed
    ..In this study we assayed survivability of the mildly pathogenic spotted fever group rickettsia, Rickettsia parkeri, in bed bugs after feeding on R. parkeri-infected chicken blood...