enterococcus faecium

Summary

Summary: A species of gram-positive, coccoid bacteria whose organisms are normal flora of the intestinal tract. Unlike ENTEROCOCCUS FAECALIS, this species may produce an alpha-hemolytic reaction on blood agar and is unable to utilize pyruvic acid as an energy source.

Top Publications

  1. Sánchez Valenzuela A, Lavilla Lerma L, Benomar N, Galvez A, Pérez Pulido R, Abriouel H. Phenotypic and molecular antibiotic resistance profile of Enterococcus faecalis and Enterococcus faecium isolated from different traditional fermented foods. Foodborne Pathog Dis. 2013;10:143-9 pubmed publisher
    A collection of 55 enterococci (41 Enterococcus faecium and 14 E. faecalis strains) isolated from various traditional fermented foodstuffs of both animal and vegetable origins, and water was evaluated for resistance against 15 antibiotics...
  2. Rathnayake I, Hargreaves M, Huygens F. SNP diversity of Enterococcus faecalis and Enterococcus faecium in a South East Queensland waterway, Australia, and associated antibiotic resistance gene profiles. BMC Microbiol. 2011;11:201 pubmed publisher
    Enterococcus faecalis and Enterococcus faecium are associated with faecal pollution of water, linked to swimmer-associated gastroenteritis and demonstrate a wide range of antibiotic resistance...
  3. Borrero J, Kunze G, Jimenez J, Böer E, Gútiez L, Herranz C, et al. Cloning, production, and functional expression of the bacteriocin enterocin A, produced by Enterococcus faecium T136, by the yeasts Pichia pastoris, Kluyveromyces lactis, Hansenula polymorpha, and Arxula adeninivorans. Appl Environ Microbiol. 2012;78:5956-61 pubmed publisher
    The bacteriocin enterocin A (EntA) produced by Enterococcus faecium T136 has been successfully cloned and produced by the yeasts Pichia pastoris X-33EA, Kluyveromyces lactis GG799EA, Hansenula polymorpha KL8-1EA, and Arxula adeninivorans ..
  4. Rathnayake I, Hargreaves M, Huygens F. Genotyping of Enterococcus faecalis and Enterococcus faecium isolates by use of a set of eight single nucleotide polymorphisms. J Clin Microbiol. 2011;49:367-72 pubmed publisher
    A single nucleotide polymorphism (SNP) genotyping method for Enterococcus faecalis and Enterococcus faecium was developed using the "Minimum SNPs" program. SNP sets were interrogated using allele-specific real-time PCR...
  5. Cheng V, Tai J, Ng M, Chan J, Wong S, Li I, et al. Extensive contact tracing and screening to control the spread of vancomycin-resistant Enterococcus faecium ST414 in Hong Kong. Chin Med J (Engl). 2012;125:3450-7 pubmed
    ..003), or vancomycin (P = 0.001) when compared with the controls. Extensive contact tracing and screening with a "search-and-confine" strategy was a successful tool for outbreak control in our healthcare region. ..
  6. Lam M, Seemann T, Bulach D, Gladman S, Chen H, Haring V, et al. Comparative analysis of the first complete Enterococcus faecium genome. J Bacteriol. 2012;194:2334-41 pubmed publisher
    ..In particular, infections caused by vancomycin-resistant Enterococcus faecium are becoming increasingly common. Comparative and functional genomic studies of E...
  7. Wang Y, Yu Y, Pan B, Hao P, Li Y, Shao Z, et al. Optimizing hybrid assembly of next-generation sequence data from Enterococcus faecium: a microbe with highly divergent genome. BMC Syst Biol. 2012;6 Suppl 3:S21 pubmed publisher
    ..Bacterium Enterococcus faecium emerged as an important nosocomial pathogen that were often associated with resistance to common ..
  8. Ganesh B, Richter J, Blaut M, Loh G. Enterococcus faecium NCIMB 10415 does not protect interleukin-10 knock-out mice from chronic gut inflammation. Benef Microbes. 2012;3:43-50 pubmed publisher
    b>Enterococcus faecium NCIMB 10415 reduces diarrhoea incidence and duration in animals and human study subjects...
  9. Conde Estévez D, Grau S, Albanell J, Terradas R, Salvado M, Knobel H. Clinical characteristics and outcomes of patients with vancomycin-susceptible Enterococcus faecalis and Enterococcus faecium bacteraemia in cancer patients. Eur J Clin Microbiol Infect Dis. 2011;30:103-8 pubmed publisher
    ..faecium should be considered in cancer patients suspected of having bacteraemia. ..

More Information

Publications106 found, 100 shown here

  1. Cao G, Zeng X, Chen A, Zhou L, Zhang L, Xiao Y, et al. Effects of a probiotic, Enterococcus faecium, on growth performance, intestinal morphology, immune response, and cecal microflora in broiler chickens challenged with Escherichia coli K88. Poult Sci. 2013;92:2949-55 pubmed publisher
    The effects of feeding dehydrated Enterococcus faecium on growth performance, immune response, and cecal microflora in broiler chickens challenged with Escherichia coli K88 were investigated...
  2. Tran T, Panesso D, Gao H, Roh J, Munita J, Reyes J, et al. Whole-genome analysis of a daptomycin-susceptible enterococcus faecium strain and its daptomycin-resistant variant arising during therapy. Antimicrob Agents Chemother. 2013;57:261-8 pubmed publisher
    ..However, the genetic bases for DAP resistance in Enterococcus faecium are unclear. We performed whole-genome comparative analysis of a clinical strain pair, DAP-susceptible E...
  3. Laverde Gomez J, van Schaik W, Freitas A, Coque T, Weaver K, Francia M, et al. A multiresistance megaplasmid pLG1 bearing a hylEfm genomic island in hospital Enterococcus faecium isolates. Int J Med Microbiol. 2011;301:165-75 pubmed publisher
    b>Enterococcus faecium is considered to be a nosocomial pathogen with increasing medical importance...
  4. Choi H, Nam D, Peck K, Song J, Shin D, Ko K. Loss of vancomycin resistance not completely dependent on the Tn1546 element in Enterococcus faecium isolates. Diagn Microbiol Infect Dis. 2011;69:105-10 pubmed publisher
    We investigated characteristics of 3 Enterococcus faecium strains (SHY-1, SHY-2, and SHY-3) isolated successively from 1 patient. In vitro susceptibility testing was performed using broth microdilution method...
  5. Ntokou E, Stathopoulos C, Kristo I, Dimitroulia E, Labrou M, Vasdeki A, et al. Intensive care unit dissemination of multiple clones of linezolid-resistant Enterococcus faecalis and Enterococcus faecium. J Antimicrob Chemother. 2012;67:1819-23 pubmed publisher
    ..Sixteen separate patients were infected and/or colonized by 22 LR enterococcal isolates (17 Enterococcus faecium and 5 Enterococcus faecalis)...
  6. Braga T, Pomba C, Lopes M. High-level vancomycin resistant Enterococcus faecium related to humans and pigs found in dust from pig breeding facilities. Vet Microbiol. 2013;161:344-9 pubmed publisher
    ..Among the isolated high-level vancomycin resistant Enterococcus faecium carrying the vanA genotype, we found multilocus sequence types closely related to pig and human isolates ..
  7. Donabedian S, Perri M, Abdujamilova N, Gordoncillo M, Naqvi A, Reyes K, et al. Characterization of vancomycin-resistant Enterococcus faecium isolated from swine in three Michigan counties. J Clin Microbiol. 2010;48:4156-60 pubmed publisher
    ..Vancomycin-resistant Enterococcus faecium (VREF) was isolated from six pigs but not from humans or any animal other than pigs...
  8. Kreuzer S, Machnowska P, Asmus J, Sieber M, Pieper R, Schmidt M, et al. Feeding of the probiotic bacterium Enterococcus faecium NCIMB 10415 differentially affects shedding of enteric viruses in pigs. Vet Res. 2012;43:58 pubmed publisher
    ..groups of sows and their piglets were fed with or without feed supplementation of the probiotic bacterium Enterococcus faecium NCIMB 10415...
  9. Ditu L, Chifiriuc M, Bezirtzoglou E, Voltsi C, Bleotu C, Pelinescu D, et al. Modulation of virulence and antibiotic susceptibility of enteropathogenic Escherichia coli strains by Enterococcus faecium probiotic strain culture fractions. Anaerobe. 2011;17:448-51 pubmed publisher
    ..This study demonstrates that the plurifactorial anti-infective action of probiotics is also due to the modulation of virulence factors and antibiotic susceptibility expression in E. coli pathogenic strains. ..
  10. Gagnon S, Levesque S, Lefebvre B, Bourgault A, Labbe A, Roger M. vanA-containing Enterococcus faecium susceptible to vancomycin and teicoplanin because of major nucleotide deletions in Tn1546. J Antimicrob Chemother. 2011;66:2758-62 pubmed publisher
    During the course of routine screening for vancomycin-resistant enterococci (VRE), we found six Enterococcus faecium isolates positive for vanA by PCR, but susceptible to vancomycin and teicoplanin by phenotypic testing...
  11. Vignaroli C, Zandri G, Aquilanti L, Pasquaroli S, Biavasco F. Multidrug-resistant enterococci in animal meat and faeces and co-transfer of resistance from an Enterococcus durans to a human Enterococcus faecium. Curr Microbiol. 2011;62:1438-47 pubmed publisher
    ..All 48 MDR enterococci were susceptible to linezolid and daptomycin. Enterococcus faecalis (16), Enterococcus faecium (8), Enterococcus mundtii (2) and Enterococcus gallinarum (1) were identified in meat, and E...
  12. Bybee S, Scorza A, Lappin M. Effect of the probiotic Enterococcus faecium SF68 on presence of diarrhea in cats and dogs housed in an animal shelter. J Vet Intern Med. 2011;25:856-60 pubmed publisher
    ..For 4 weeks, animals in 1 room for each species was fed Enterococcus faecium SF68 while animals in the other room were fed a placebo...
  13. Palazzo I, Pitondo Silva A, Levy C, da Costa Darini A. Changes in vancomycin-resistant Enterococcus faecium causing outbreaks in Brazil. J Hosp Infect. 2011;79:70-4 pubmed publisher
    ..The majority of vancomycin-resistant Enterococcus faecium (VRE(fm)) connected to outbreaks worldwide pertains to the clonal complex 17 (CC17)...
  14. Furukawa T, Yoshida T, Suzuki Y. Application of PFGE to source tracking of faecal pollution in coastal recreation area: a case study in Aoshima Beach, Japan. J Appl Microbiol. 2011;110:688-96 pubmed publisher
    ..b>Enterococcus faecium, an enterococcus, was used as a faecal indicator bacterium in this study...
  15. Lindenstrauss A, Pavlovic M, Bringmann A, Behr J, Ehrmann M, Vogel R. Comparison of genotypic and phenotypic cluster analyses of virulence determinants and possible role of CRISPR elements towards their incidence in Enterococcus faecalis and Enterococcus faecium. Syst Appl Microbiol. 2011;34:553-60 pubmed publisher
    Enterococcus faecalis and Enterococcus faecium are human commensals frequently found in fermented foods or used as probiotics, but also recognized as opportunistic pathogens...
  16. Sarti M, Campanile F, Sabia C, Santagati M, Gargiulo R, Stefani S. Polyclonal diffusion of beta-lactamase-producing Enterococcus faecium. J Clin Microbiol. 2012;50:169-72 pubmed publisher
    We describe here the isolation of 8 beta-lactamase-producing multidrug-resistant Enterococcus faecium isolates in 2010...
  17. Bednorz C, Guenther S, Oelgeschläger K, Kinnemann B, Pieper R, Hartmann S, et al. Feeding the probiotic Enterococcus faecium strain NCIMB 10415 to piglets specifically reduces the number of Escherichia coli pathotypes that adhere to the gut mucosa. Appl Environ Microbiol. 2013;79:7896-904 pubmed publisher
    Feed supplementation with the probiotic Enterococcus faecium for piglets has been found to reduce pathogenic gut microorganisms...
  18. Johnson P, Ballard S, Grabsch E, Stinear T, Seemann T, Young H, et al. A sustained hospital outbreak of vancomycin-resistant Enterococcus faecium bacteremia due to emergence of vanB E. faecium sequence type 203. J Infect Dis. 2010;202:1278-86 pubmed publisher
    A significant increase in the rate of vancomycin-resistant Enterococcus faecium (VREfm) bacteremia at our health service, despite improved infection control, prompted us to investigate the cause. E...
  19. Rana S, Kumar A, Berven K, Cumper K, Walia S. Isolation of Tn1546-like elements in vancomycin-resistant Enterococcus faecium isolated from wood frogs: an emerging risk for zoonotic bacterial infections to humans. J Appl Microbiol. 2011;110:35-43 pubmed publisher
    Isolation and characterization of vancomycin-resistant enterococci (VRE), mainly Enterococcus faecium, from the faecal pellet of wood frogs (Rana sylvatica)...
  20. Paganelli F, Willems R, Leavis H. Optimizing future treatment of enterococcal infections: attacking the biofilm?. Trends Microbiol. 2012;20:40-9 pubmed publisher
    Enterococcus faecalis and Enterococcus faecium are among the leading causative agents of nosocomial infections and are infamous for their resistance to many antibiotics...
  21. Werner G, Freitas A, Coque T, Sollid J, Lester C, Hammerum A, et al. Host range of enterococcal vanA plasmids among Gram-positive intestinal bacteria. J Antimicrob Chemother. 2011;66:273-82 pubmed publisher
    ..glycopeptide resistance is encoded by the vanA transposon Tn1546 located mainly on transferable plasmids in Enterococcus faecium. The limited occurrence in other species could be due to the lack of inter-species transferability and/or ..
  22. Willems R, Top J, van Schaik W, Leavis H, Bonten M, Sirén J, et al. Restricted gene flow among hospital subpopulations of Enterococcus faecium. MBio. 2012;3:e00151-12 pubmed publisher
    b>Enterococcus faecium has recently emerged as an important multiresistant nosocomial pathogen...
  23. Rathnayake I, Hargreaves M, Huygens F. Antibiotic resistance and virulence traits in clinical and environmental Enterococcus faecalis and Enterococcus faecium isolates. Syst Appl Microbiol. 2012;35:326-33 pubmed publisher
    ..compared virulence and antibiotic resistance traits in clinical and environmental Enterococcus faecalis and Enterococcus faecium isolates. E. faecalis isolates harboured a broader spectrum of virulence determinants compared to E...
  24. Zhang X, Paganelli F, Bierschenk D, Kuipers A, Bonten M, Willems R, et al. Genome-wide identification of ampicillin resistance determinants in Enterococcus faecium. PLoS Genet. 2012;8:e1002804 pubmed publisher
    b>Enterococcus faecium has become a nosocomial pathogen of major importance, causing infections that are difficult to treat owing to its multi-drug resistance...
  25. Sletvold H, Johnsen P, Hamre I, Simonsen G, Sundsfjord A, Nielsen K. Complete sequence of Enterococcus faecium pVEF3 and the detection of an omega-epsilon-zeta toxin-antitoxin module and an ABC transporter. Plasmid. 2008;60:75-85 pubmed publisher
    Glycopeptide resistant Enterococcus faecium (GREF) persists on Norwegian poultry farms despite the ban on the growth promoter avoparcin. The biological basis for long-term persistence of avoparcin resistance is not fully understood...
  26. Mazaheri Nezhad Fard R, Barton M, Heuzenroeder M. Bacteriophage-mediated transduction of antibiotic resistance in enterococci. Lett Appl Microbiol. 2011;52:559-64 pubmed publisher
    ..gallinarum to Ent. faecalis (tetracycline resistance) and from Ent. faecalis to Enterococcus faecium, Enterococcus hirae/durans and Enterococcus casseliflavus (gentamicin resistance)...
  27. Tong S, Xie S, Richardson L, Ballard S, Dakh F, Grabsch E, et al. High-resolution melting genotyping of Enterococcus faecium based on multilocus sequence typing derived single nucleotide polymorphisms. PLoS ONE. 2011;6:e29189 pubmed publisher
    ..a single nucleotide polymorphism (SNP) nucleated high-resolution melting (HRM) technique to genotype Enterococcus faecium. Eight SNPs were derived from the E...
  28. Zhu W, Murray P, Huskins W, Jernigan J, McDonald L, Clark N, et al. Dissemination of an Enterococcus Inc18-Like vanA plasmid associated with vancomycin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2010;54:4314-20 pubmed publisher
    ..Although VRE isolates with the VRSA-associated Inc18-like vanA plasmid were more common in Michigan, they remain rare. Periodic surveillance of VRE isolates for the plasmid may be useful in predicting the occurrence of VRSA. ..
  29. Chibebe Junior J, Fuchs B, Sabino C, Junqueira J, Jorge A, Ribeiro M, et al. Photodynamic and antibiotic therapy impair the pathogenesis of Enterococcus faecium in a whole animal insect model. PLoS ONE. 2013;8:e55926 pubmed publisher
    b>Enterococcus faecium has emerged as one of the most important pathogens in healthcare-associated infections worldwide due to its intrinsic and acquired resistance to many antibiotics, including vancomycin...
  30. Ubeda C, Bucci V, Caballero S, Djukovic A, Toussaint N, Equinda M, et al. Intestinal microbiota containing Barnesiella species cures vancomycin-resistant Enterococcus faecium colonization. Infect Immun. 2013;81:965-73 pubmed publisher
    ..Our studies indicate that obligate anaerobic bacteria belonging to the Barnesiella genus enable clearance of intestinal VRE colonization and may provide novel approaches to prevent the spread of highly antibiotic-resistant bacteria. ..
  31. Qin X, Galloway Peña J, Sillanpaa J, Roh J, Nallapareddy S, Chowdhury S, et al. Complete genome sequence of Enterococcus faecium strain TX16 and comparative genomic analysis of Enterococcus faecium genomes. BMC Microbiol. 2012;12:135 pubmed publisher
    ..causes of hospital-acquired infections in the United States and Europe, with Enterococcus faecalis and Enterococcus faecium being the two most common species isolated from enterococcal infections...
  32. Xu X, Lin D, Yan G, Ye X, Wu S, Guo Y, et al. vanM, a new glycopeptide resistance gene cluster found in Enterococcus faecium. Antimicrob Agents Chemother. 2010;54:4643-7 pubmed publisher
    ..We investigated a clinical strain of Enterococcus faecium Efm-HS0661 that was isolated in 2006 from an inpatient with intra-abdominal infection in Shanghai...
  33. Palmer K, Daniel A, Hardy C, Silverman J, Gilmore M. Genetic basis for daptomycin resistance in enterococci. Antimicrob Agents Chemother. 2011;55:3345-56 pubmed publisher
    ..Since its introduction, resistance to daptomycin by strains of Enterococcus faecalis and Enterococcus faecium has been reported but is still rare. We evolved daptomycin-resistant strains of the multidrug-resistant E...
  34. Klingspor S, Martens H, Çaushi D, Twardziok S, Aschenbach J, Lodemann U. Characterization of the effects of Enterococcus faecium on intestinal epithelial transport properties in piglets. J Anim Sci. 2013;91:1707-18 pubmed publisher
    ..The objective of the study was to examine whether the probiotic strain Enterococcus faecium NCIMB 10415 (E...
  35. Starikova I, Al Haroni M, Werner G, Roberts A, Sørum V, Nielsen K, et al. Fitness costs of various mobile genetic elements in Enterococcus faecium and Enterococcus faecalis. J Antimicrob Chemother. 2013;68:2755-65 pubmed publisher
    To determine the fitness effects of various mobile genetic elements (MGEs) in Enterococcus faecium and Enterococcus faecalis when newly acquired...
  36. Le J, Bookstaver P, Rudisill C, Hashem M, Iqbal R, James C, et al. Treatment of meningitis caused by vancomycin-resistant Enterococcus faecium: high-dose and combination daptomycin therapy. Ann Pharmacother. 2010;44:2001-6 pubmed publisher
    To report 3 successful treatments of vancomycin-resistant Enterococcus faecium meningitis in adults using daptomycin and either linezolid or gentamicin.
  37. Yoon Y, Lee S, Lee J, Kim H, Kim J, Park D, et al. Risk factors for prolonged carriage of vancomycin-resistant Enterococcus faecium among patients in intensive care units: a case-control study. J Antimicrob Chemother. 2011;66:1831-8 pubmed publisher
    The aim of this study was to identify the risk factors for prolonged carriage of vancomycin-resistant Enterococcus faecium (VREF) in intensive care units (ICUs).
  38. Tsai H, Liao C, Chen Y, Lu P, Huang C, Lu C, et al. Trends in susceptibility of vancomycin-resistant Enterococcus faecium to tigecycline, daptomycin, and linezolid and molecular epidemiology of the isolates: results from the Tigecycline In Vitro Surveillance in Taiwan (TIST) study, 2006 to 2010. Antimicrob Agents Chemother. 2012;56:3402-5 pubmed publisher
    Among the 219 vancomycin-resistant Enterococcus faecium isolates collected in 20 Taiwanese hospitals from 2006 to 2010, all were susceptible to linezolid and daptomycin, and 98.6% were susceptible to tigecycline...
  39. Choudhury T, Singh K, Sillanpaa J, Nallapareddy S, Murray B. Importance of two Enterococcus faecium loci encoding Gls-like proteins for in vitro bile salts stress response and virulence. J Infect Dis. 2011;203:1147-54 pubmed publisher
    ..Here, we identified 2 gene clusters in Enterococcus faecium each encoding a homolog of Gls24 (Gls33 and Gls20; designated on the basis of their predicted sizes) and of ..
  40. Bjørkeng E, Rasmussen G, Sundsfjord A, Sjöberg L, Hegstad K, Söderquist B. Clustering of polyclonal VanB-type vancomycin-resistant Enterococcus faecium in a low-endemic area was associated with CC17-genogroup strains harbouring transferable vanB2-Tn5382 and pRUM-like repA containing plasmids with axe-txe plasmid addiction s. APMIS. 2011;119:247-58 pubmed publisher
    VanB-type vancomycin-resistant Enterococcus faecium isolates (n = 17) from 15 patients at the Örebro University hospital in Sweden during a span of 18 months was characterized...
  41. Kropec A, Sava I, Vonend C, Sakinc T, Grohmann E, Huebner J. Identification of SagA as a novel vaccine target for the prevention of Enterococcus faecium infections. Microbiology. 2011;157:3429-34 pubmed publisher
    ..Enterococci, especially Enterococcus faecium, are well-known pathogens of hospitalized patients and are frequently linked with resistance against ..
  42. Gröbner S, Beck J, Schaller M, Autenrieth I, Schulte B. Characterization of an Enterococcus faecium small-colony variant isolated from blood culture. Int J Med Microbiol. 2012;302:40-4 pubmed publisher
    ..We here report for the first time the isolation of an Enterococcus faecium SCV phenotype...
  43. Teo J, Krishnan P, Jureen R, Lin R. Detection of an unusual van genotype in a vancomycin-resistant Enterococcus faecium hospital isolate. J Clin Microbiol. 2011;49:4297-8 pubmed publisher
    We highlight the detection of a rare vanM genotype in Enterococcus faecium. This isolate exhibited a VanB phenotype, with high levels of resistance to vancomycin (MIC, >256 mg/liter) and susceptibility to teicoplanin (MIC, 1 mg/liter)...
  44. Sakoulas G, Bayer A, POGLIANO J, Tsuji B, Yang S, Mishra N, et al. Ampicillin enhances daptomycin- and cationic host defense peptide-mediated killing of ampicillin- and vancomycin-resistant Enterococcus faecium. Antimicrob Agents Chemother. 2012;56:838-44 pubmed publisher
    We studied an ampicillin- and vancomycin-resistant Enterococcus faecium (VRE) isolate from a patient with endocarditis and bacteremia refractory to treatment with daptomycin (6 mg/kg of body weight) plus linezolid...
  45. Mafamane H, Szabo I, Schmidt M, Filter M, Walk N, Tedin K, et al. Studies on the effect of an Enterococcus faecium probiotic on T cell populations in peripheral blood and intestinal epithelium and on the susceptibility to Salmonella during a challenge infection with Salmonella Typhimurium in piglets. Arch Anim Nutr. 2011;65:415-30 pubmed
    Although Enterococcus faecium is used as a probiotic feed supplement in animal production, feeding of the bacterium to piglets resulted in a more severe infection with Salmonella Typhimurium DT104 during a challenge experiment...
  46. Cha J, Jung Y, Lee H, Yoo J, Lee Y. Comparison of genetic epidemiology of vancomycin-resistant Enterococcus faecium isolates from humans and poultry. J Med Microbiol. 2012;61:1121-8 pubmed publisher
    ..was conducted to investigate the molecular characteristics and genetic relatedness of vancomycin-resistant Enterococcus faecium (VREF) isolates obtained from humans and poultry in Korea...
  47. Werner G, Fleige C, Fessler A, Timke M, Kostrzewa M, Zischka M, et al. Improved identification including MALDI-TOF mass spectrometry analysis of group D streptococci from bovine mastitis and subsequent molecular characterization of corresponding Enterococcus faecalis and Enterococcus faecium isolates. Vet Microbiol. 2012;160:162-9 pubmed publisher
    ..Classical and MALDI TOF MS analyses identified 64 Enterococcus faecalis and 37 Enterococcus faecium isolates which were confirmed by species-specific PCRs...
  48. Jansson D, Nilsson O, Lindblad J, Greko C, Bengtsson B. Inter-batch contamination and potential sources of vancomycin-resistant Enterococcus faecium on broiler farms. Br Poult Sci. 2012;53:790-9 pubmed publisher
    1. Vancomycin-resistant Enterococcus faecium (VRE(fm)) has recently spread among Swedish broiler farms...
  49. Zhang X, Top J, de Been M, Bierschenk D, Rogers M, Leendertse M, et al. Identification of a genetic determinant in clinical Enterococcus faecium strains that contributes to intestinal colonization during antibiotic treatment. J Infect Dis. 2013;207:1780-6 pubmed publisher
    Intestinal colonization by antibiotic-resistant Enterococcus faecium is the first step in a process that can lead to infections in hospitalized patients...
  50. Al Ahmad A, Maier J, Follo M, Spitzmüller B, Wittmer A, Hellwig E, et al. Food-borne enterococci integrate into oral biofilm: an in vivo study. J Endod. 2010;36:1812-9 pubmed publisher
    ..To date, enterococci have been considered to be only transiently present in the oral cavity. The aim of this study was to examine whether different enterococci from food are able to reside in oral biofilm...
  51. Xu H, Tian R, Chen D, Xiao F, Nie Z, Hu Y, et al. Nosocomial spread of hospital-adapted CC17 vancomycin-resistant Enterococcus faecium in a tertiary-care hospital of Beijing, China. Chin Med J (Engl). 2011;124:498-503 pubmed
    ..The objective of this study was to analyze the molecular features of the isolates and the control measures used to eradicate a VRE outbreak in a tertiary institution in China...
  52. Tremblay C, Letellier A, Quessy S, Boulianne M, Daignault D, Archambault M. Multiple-antibiotic resistance of Enterococcus faecalis and Enterococcus faecium from cecal contents in broiler chicken and turkey flocks slaughtered in Canada and plasmid colocalization of tetO and ermB genes. J Food Prot. 2011;74:1639-48 pubmed publisher
    ..and investigate plasmid colocalization of tetracycline and macrolide genes in Enterococcus faecalis and Enterococcus faecium from broiler chicken and turkey flocks in Canada. A total of 387 E. faecalis and E...
  53. Bychowska A, Theilacker C, Czerwicka M, Marszewska K, Huebner J, Holst O, et al. Chemical structure of wall teichoic acid isolated from Enterococcus faecium strain U0317. Carbohydr Res. 2011;346:2816-9 pubmed publisher
    Wall teichoic acid (WTA) was isolated from Enterococcus faecium strain U0317 and structurally characterized using (1)H, (13)C, and (31)P NMR spectroscopy, including two-dimensional COSY, TOCSY, ROESY, HMQC, and HMBC experiments...
  54. Knoll B, Hellmann M, Kotton C. Vancomycin-resistant Enterococcus faecium meningitis in adults: case series and review of the literature. Scand J Infect Dis. 2013;45:131-9 pubmed publisher
    Vancomycin-resistant Enterococcus faecium (VR E. faecium) is a rare cause of meningitis and is associated with substantial mortality. Limited therapeutic options are available for the treatment of VR E. faecium meningitis...
  55. Wang Z, Chai W, Burwinkel M, Twardziok S, Wrede P, Palissa C, et al. Inhibitory influence of Enterococcus faecium on the propagation of swine influenza A virus in vitro. PLoS ONE. 2013;8:e53043 pubmed publisher
    ..Here we address this question by assessing the inhibitory potential of the probiotic Enterococcus faecium NCIMB 10415 (E...
  56. Zhao X, Guo Y, Guo S, Tan J. Effects of Clostridium butyricum and Enterococcus faecium on growth performance, lipid metabolism, and cecal microbiota of broiler chickens. Appl Microbiol Biotechnol. 2013;97:6477-88 pubmed publisher
    To investigate the effects of Clostridium butyricum and Enterococcus faecium on the growth performance, lipid metabolism, and cecal microbiota of broilers, 264 one-day-old male Ross 308 broiler chicks were randomly allocated into four ..
  57. Todorov S, Wachsman M, Tomé E, Dousset X, Destro M, Dicks L, et al. Characterisation of an antiviral pediocin-like bacteriocin produced by Enterococcus faecium. Food Microbiol. 2010;27:869-79 pubmed publisher
    The bacteriocin-producing strain Enterococcus faecium ST5Ha was isolated from smoked salmon and identified by biomolecular techniques. Ent...
  58. Xu Z, Li L, Shirtliff M, Peters B, Peng Y, Alam M, et al. First report of class 2 integron in clinical Enterococcus faecalis and class 1 integron in Enterococcus faecium in South China. Diagn Microbiol Infect Dis. 2010;68:315-7 pubmed publisher
    ..This is the first report of class 2 integron in Enterococcus faecalis and class 1 integron in Enterococcus faecium.
  59. Zhang X, Vrijenhoek J, Bonten M, Willems R, van Schaik W. A genetic element present on megaplasmids allows Enterococcus faecium to use raffinose as carbon source. Environ Microbiol. 2011;13:518-28 pubmed publisher
    b>Enterococcus faecium is a commensal of the gastrointestinal tract of humans and animals. Since the 1990s, it has also emerged as a nosocomial pathogen. Little is known about carbon metabolism of E...
  60. Furukawa T, Takahashi H, Yoshida T, Suzuki Y. Genotypic analysis of Enterococci isolated from fecal-polluted water from different sources by pulsed-field gel electrophoresis (PFGE) for application to microbial source tracking. Microbes Environ. 2011;26:181-3 pubmed
    ..We tried to distinguish the genotypes of Enterococcus faecium collected from fecal-contaminated water using PFGE. Well identified 115 strains of E...
  61. Ruiz Garbajosa P, de Regt M, Bonten M, Baquero F, Coque T, Canton R, et al. High-density fecal Enterococcus faecium colonization in hospitalized patients is associated with the presence of the polyclonal subcluster CC17. Eur J Clin Microbiol Infect Dis. 2012;31:519-22 pubmed publisher
    b>Enterococcus faecium belonging to the polyclonal subcluster CC17, with a typical ampicillin-resistant E. faecium (AREfm) phenotype, have become prevalent among nosocomial infections around the world...
  62. Garcia Migura L, Sanchez Valenzuela A, Jensen L. Presence of glycopeptide-encoding plasmids in enterococcal isolates from food and humans in Denmark. Foodborne Pathog Dis. 2011;8:1191-7 pubmed publisher
    ..Replicons associated with sex pheromone-inducible plasmids were detected in all GR E. faecalis, whereas GR Enterococcus faecium contained plasmids known to be widely distributed among enterococci. vanA resistance is common in E...
  63. Arias C, Murray B. The rise of the Enterococcus: beyond vancomycin resistance. Nat Rev Microbiol. 2012;10:266-78 pubmed publisher
    ..discusses the factors involved in the changing epidemiology of enterococcal infections, with an emphasis on Enterococcus faecium as an emergent and challenging nosocomial problem...
  64. Lu C, Chuang Y, Chang H, Chen Y, Wang J, Chang S. Microbiological and clinical characteristics of vancomycin-resistant Enterococcus faecium bacteraemia in Taiwan: implication of sequence type for prognosis. J Antimicrob Chemother. 2012;67:2243-9 pubmed publisher
    Vancomycin-resistant enterococci (VRE), particularly vancomycin-resistant Enterococcus faecium (VREfm), have emerged among the leading pathogens causing hospital-acquired infections worldwide...
  65. Cai J, Hu Y, Zhang R, Zhou H, Chen G. Linezolid-resistant clinical isolates of meticillin-resistant coagulase-negative staphylococci and Enterococcus faecium from China. J Med Microbiol. 2012;61:1568-73 pubmed publisher
    ..capitis, four Staphylococcus cohnii, two Staphylococcus haemolyticus and one Staphylococcus sciuri, and an Enterococcus faecium isolate with various levels of linezolid resistance were isolated from intensive care units in a Chinese ..
  66. de Been M, van Schaik W, Cheng L, Corander J, Willems R. Recent recombination events in the core genome are associated with adaptive evolution in Enterococcus faecium. Genome Biol Evol. 2013;5:1524-35 pubmed publisher
    Reasons for the rising clinical impact of the bacterium Enterococcus faecium include the species' rapid acquisition of adaptive genetic elements. Here, we focused on the impact of recombination on the evolution of E. faecium...
  67. Jung Y, Shin E, Kim O, Yoo J, Lee K, Yoo J, et al. Characterization of two newly identified genes, vgaD and vatH, [corrected] conferring resistance to streptogramin A in Enterococcus faecium. Antimicrob Agents Chemother. 2010;54:4744-9 pubmed publisher
    We characterized two new streptogramin A resistance genes from quinupristin-dalfopristin-resistant Enterococcus faecium JS79, which was selected from 79 E. faecium isolates lacking known genes encoding streptogramin A acetyltransferase...
  68. Henard S, Lozniewski A, Aissa N, Jouzeau N, Rabaud C. Evaluation of the duration of vanA vancomycin-resistant Enterococcus faecium carriage and clearance during a large-scale outbreak in a region of eastern France. Am J Infect Control. 2011;39:169-71 pubmed publisher
    ..Recurrence was observed despite as many as 3 negative cultures. As a result, we propose another definition for VRE clearance...
  69. Capozzi V, Ladero V, Beneduce L, Fernandez M, Alvarez M, Benoit B, et al. Isolation and characterization of tyramine-producing Enterococcus faecium strains from red wine. Food Microbiol. 2011;28:434-9 pubmed publisher
    b>Enterococcus faecium strains were isolated from red wines undergoing malolactic fermentation and identified by comparison of their 16S rDNA gene sequences with those included in the GenEMBL Databases...
  70. Werner G, Fleige C, Geringer U, van Schaik W, Klare I, Witte W. IS element IS16 as a molecular screening tool to identify hospital-associated strains of Enterococcus faecium. BMC Infect Dis. 2011;11:80 pubmed publisher
    Hospital strains of Enterococcus faecium could be characterized and typed by various molecular methods (MLST, AFLP, MLVA) and allocated to a distinct clonal complex known as MLST CC17...
  71. de Regt M, van Schaik W, van Luit Asbroek M, Dekker H, van Duijkeren E, Koning C, et al. Hospital and community ampicillin-resistant Enterococcus faecium are evolutionarily closely linked but have diversified through niche adaptation. PLoS ONE. 2012;7:e30319 pubmed publisher
    Ampicillin-resistant Enterococcus faecium (ARE) has emerged as a nosocomial pathogen. Here, we quantified ARE carriage in different community sources and determined genetic relatedness with hospital ARE.
  72. Humphries R, Kelesidis T, Tewhey R, Rose W, Schork N, Nizet V, et al. Genotypic and phenotypic evaluation of the evolution of high-level daptomycin nonsusceptibility in vancomycin-resistant Enterococcus faecium. Antimicrob Agents Chemother. 2012;56:6051-3 pubmed publisher
    Whole-genome sequencing and cell membrane studies of three clonal Enterococcus faecium strains with daptomycin MICs of 4, 32, and 192 ?g/ml were performed, revealing nonsynonymous single nucleotide variants in eight open reading frames, ..
  73. Mishra N, Bayer A, Tran T, Shamoo Y, Mileykovskaya E, Dowhan W, et al. Daptomycin resistance in enterococci is associated with distinct alterations of cell membrane phospholipid content. PLoS ONE. 2012;7:e43958 pubmed publisher
    ..Here we characterized changes in CM phospholipid profiles associated with development of DAP resistance in clinical enterococcal strains...
  74. Boss L, Labudda Ł, Wegrzyn G, Hayes F, Kedzierska B. The axe-txe complex of Enterococcus faecium presents a multilayered mode of toxin-antitoxin gene expression regulation. PLoS ONE. 2013;8:e73569 pubmed publisher
  75. Sillanpaa J, Nallapareddy S, Singh K, Prakash V, Fothergill T, Ton That H, et al. Characterization of the ebp(fm) pilus-encoding operon of Enterococcus faecium and its role in biofilm formation and virulence in a murine model of urinary tract infection. Virulence. 2010;1:236-46 pubmed
    ..identified 15 genes encoding putative surface proteins with features of MSCRAMMs and/or pili in the Enterococcus faecium TX0016 (DO) genome, including four predicted pilus-encoding gene clusters; we also demonstrated that one of ..
  76. Foucault M, Depardieu F, Courvalin P, Grillot Courvalin C. Inducible expression eliminates the fitness cost of vancomycin resistance in enterococci. Proc Natl Acad Sci U S A. 2010;107:16964-9 pubmed publisher
    ..the biological cost of VanB-type resistance due to acquisition of conjugative transposon Tn1549 in Enterococcus faecium and Enterococcus faecalis...
  77. Halvorsen E, Williams J, Bhimani A, Billings E, Hergenrother P. Txe, an endoribonuclease of the enterococcal Axe-Txe toxin-antitoxin system, cleaves mRNA and inhibits protein synthesis. Microbiology. 2011;157:387-97 pubmed publisher
    ..TA) pair, Axe-Txe, that was initially identified on the multidrug-resistance plasmid pRUM in Enterococcus faecium. In Escherichia coli, expression of the Txe toxin is known to inhibit cell growth, and co-expression of the ..
  78. Freitas A, Coque T, Novais C, Hammerum A, Lester C, Zervos M, et al. Human and swine hosts share vancomycin-resistant Enterococcus faecium CC17 and CC5 and Enterococcus faecalis CC2 clonal clusters harboring Tn1546 on indistinguishable plasmids. J Clin Microbiol. 2011;49:925-31 pubmed publisher
    ..Thirty clonally related Enterococcus faecium clonal complex 5 (CC5) isolates (17 sequence type 6 [ST6], 6 ST5, 5 ST185, 1 ST147, and 1 ST493) were ..
  79. Heikens E, Singh K, Jacques Palaz K, van Luit Asbroek M, Oostdijk E, Bonten M, et al. Contribution of the enterococcal surface protein Esp to pathogenesis of Enterococcus faecium endocarditis. Microbes Infect. 2011;13:1185-90 pubmed publisher
    The enterococcal surface protein Esp, specifically linked to nosocomial Enterococcus faecium, is involved in biofilm formation. To assess the role of Esp in endocarditis, a biofilm-associated infection, an Esp-expressing E...
  80. Morris D, Galvin S, Boyle F, Hickey P, Mulligan M, Cormican M. Enterococcus faecium of the vanA genotype in rural drinking water, effluent, and the aqueous environment. Appl Environ Microbiol. 2012;78:596-8 pubmed publisher
    ..VRE were detected in the outflow of a wastewater treatment plant and in a single rural drinking water supply, suggesting potential for transmission to humans through environmental contamination...
  81. Lebreton F, van Schaik W, Sanguinetti M, Posteraro B, Torelli R, Le Bras F, et al. AsrR is an oxidative stress sensing regulator modulating Enterococcus faecium opportunistic traits, antimicrobial resistance, and pathogenicity. PLoS Pathog. 2012;8:e1002834 pubmed publisher
    ..an oxidative stress sensor and response regulator in the important multidrug-resistant nosocomial pathogen Enterococcus faecium belonging to the MarR family and called AsrR (antibiotic and stress response regulator)...
  82. Top J, Paganelli F, Zhang X, van Schaik W, Leavis H, van Luit Asbroek M, et al. The Enterococcus faecium enterococcal biofilm regulator, EbrB, regulates the esp operon and is implicated in biofilm formation and intestinal colonization. PLoS ONE. 2013;8:e65224 pubmed publisher
    Nowadays, Enterococcus faecium is one of the leading nosocomial pathogens worldwide. Strains causing clinical infections or hospital outbreaks are enriched in the enterococcal surface protein (Esp) encoding ICEEfm1 mobile genetic element...
  83. Weng P, Ramli R, Shamsudin M, Cheah Y, Hamat R. High genetic diversity of Enterococcus faecium and Enterococcus faecalis clinical isolates by pulsed-field gel electrophoresis and multilocus sequence typing from a hospital in Malaysia. Biomed Res Int. 2013;2013:938937 pubmed publisher
    ..We studied the antibiotic susceptibility profiles of Enterococcus faecium and Enterococcus faecalis and subjected them to pulsed-field gel electrophoresis (PFGE) and multilocus ..
  84. Panesso D, Montealegre M, Rincon S, Mojica M, Rice L, Singh K, et al. The hylEfm gene in pHylEfm of Enterococcus faecium is not required in pathogenesis of murine peritonitis. BMC Microbiol. 2011;11:20 pubmed publisher
    ..hylEfm (pHylEfm) were previously shown to increase gastrointestinal colonization and lethality of Enterococcus faecium in experimental peritonitis...
  85. Triboulet S, Arthur M, Mainardi J, Veckerlé C, Dubée V, Nguekam Moumi A, et al. Inactivation kinetics of a new target of beta-lactam antibiotics. J Biol Chem. 2011;286:22777-84 pubmed publisher
    ..and as a bypass mechanism conferring resistance to all ?-lactams, except carbapenems such as imipenem, in Enterococcus faecium. Investigation of the mechanism of inhibition of this new ?-lactam target showed that acylation of the E...
  86. Galloway Peña J, Rice L, Murray B. Analysis of PBP5 of early U.S. isolates of Enterococcus faecium: sequence variation alone does not explain increasing ampicillin resistance over time. Antimicrob Agents Chemother. 2011;55:3272-7 pubmed publisher
    ..S. Enterococcus faecium isolates...
  87. Meyer E, Ziegler R, Mattner F, Schwab F, Gastmeier P, Martin M. Increase of patients co-colonised or co-infected with methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecium or extended-spectrum ?-lactamase-producing Enterobacteriaceae. Infection. 2011;39:501-6 pubmed publisher
    ..co-colonised or co-infected with methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus faecium or extended-spectrum ?-lactamase (ESBL)-producing Enterobacteriaceae in four German tertiary care hospitals.
  88. Coşkun F, Mumcuoglu I, Aksu N, Karahan Z, Us E, Tekeli F, et al. [Phenotypic and genotypic traits of vancomycin-resistant enterococci in a public hospital: the first vanB-positive Enterococcus faecium isolates]. Mikrobiyol Bul. 2012;46:276-82 pubmed
    ..All isolates were identified as Enterococcus faecium by VITEK2 system (bioMerieux, France)...
  89. Sharifi Y, Ghotaslou R, Naghili B, Hasani A, Aghazadeh M, Milani M, et al. Molecular screening of virulence genes in high-level gentamicin-resistant Enterococcus faecalis and Enterococcus faecium isolated from clinical specimens in Northwest Iran. Indian J Med Microbiol. 2012;30:175-81 pubmed publisher
    The present study screened clinical isolates of Enterococcus faecalis and Enterococcus faecium to determine the prevalence of high-level gentamicin-resistant enterococci and the potential virulence genes among them.
  90. Sadowy E, Sienko A, Gawryszewska I, Bojarska A, Malinowska K, Hryniewicz W. High abundance and diversity of antimicrobial resistance determinants among early vancomycin-resistant Enterococcus faecium in Poland. Eur J Clin Microbiol Infect Dis. 2013;32:1193-203 pubmed publisher
    ..structure, antimicrobial resistance phenotypes and their determinants among early vancomycin-resistant Enterococcus faecium (VREm) isolates in Poland...
  91. Ruzon F, de Paula S, Kanoshiki R, Pereira Santos J, Kerbauy G, Kobayashi R, et al. Virulence determinants in vancomycin-resistant Enterococcus faecium vanA isolated from different sources at University Hospital of Londrina, Paraná, Brazil. J Microbiol. 2010;48:814-21 pubmed publisher
    b>Enterococcus faecium, especially those showing multidrug resistance, has emerged as a significant cause of healthcare-associated infections worldwide...
  92. Aligholi M, Emaneini M, Taherikalani M, Shahsavan S, Jabalameli F, Asadollahi P, et al. Time-kill study and synergistic activity of cell-wall inhibitor antibiotics in combination with gentamicin against Enterococcus faecalis and Enterococcus faecium. Acta Microbiol Immunol Hung. 2011;58:219-26 pubmed publisher
    ..In order to treat serious enterococcal infections, further clinical evaluation is needed to examine the in vitro combined effects of gentamicin and vancomycin, teicoplanin and linezolid...