helicobacter hepaticus

Summary

Summary: A species of HELICOBACTER that colonizes the CECUM and COLON of several strains of MICE, and is associated with HEPATITIS and carcinogenesis.

Top Publications

  1. Dvorak K, Coursodon Boyiddle C, Snarrenberg C, Kananurak A, Underwood M, Dvorak B. Helicobacter hepaticus increases intestinal injury in a rat model of necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol. 2013;305:G585-92 pubmed publisher
    ..b>Helicobacter hepaticus, the prototypic murine EHS, is also associated with inflammation...
  2. Morrison P, Bending D, Fouser L, Wright J, Stockinger B, Cooke A, et al. Th17-cell plasticity in Helicobacter hepaticus-induced intestinal inflammation. Mucosal Immunol. 2013;6:1143-56 pubmed publisher
    ..We report that Helicobacter hepaticus-induced typhlocolitis in specific pathogen-free IL-10(-/-) mice is associated with elevated frequencies ..
  3. Lu K, Knutson C, Wishnok J, Fox J, Tannenbaum S. Serum metabolomics in a Helicobacter hepaticus mouse model of inflammatory bowel disease reveal important changes in the microbiome, serum peptides, and intermediary metabolism. J Proteome Res. 2012;11:4916-26 pubmed publisher
    ..Recombinase-activating gene-2-deficient (Rag2(-/-)) mice infected with Helicobacter hepaticus (H...
  4. Asquith M, Boulard O, Powrie F, Maloy K. Pathogenic and protective roles of MyD88 in leukocytes and epithelial cells in mouse models of inflammatory bowel disease. Gastroenterology. 2010;139:519-29, 529.e1-2 pubmed publisher
    ..Cellular compartmentalization of MyD88 signals in the intestine allow the maintenance of host defense and prevent deleterious inflammatory responses. ..
  5. Sterzenbach T, Lee S, Brenneke B, von Goetz F, Schauer D, Fox J, et al. Inhibitory effect of enterohepatic Helicobacter hepaticus on innate immune responses of mouse intestinal epithelial cells. Infect Immun. 2007;75:2717-28 pubmed
    ..The recent analysis of the whole genome sequence of the mouse enterohepatic species Helicobacter hepaticus allowed us to perform a functional analysis of bacterial factors that may play a role in these diseases...
  6. Nagamine C, Rogers A, Fox J, Schauer D. Helicobacter hepaticus promotes azoxymethane-initiated colon tumorigenesis in BALB/c-IL10-deficient mice. Int J Cancer. 2008;122:832-8 pubmed
    ..progression of AOM-induced tumors or colitis-associated adenocarcinomas; and (ii) prior infection with Helicobacter hepaticus, a common enterohepatic bacterial pathogen in many research mouse colonies, increases the incidence, ..
  7. Mangerich A, Knutson C, Parry N, Muthupalani S, Ye W, Prestwich E, et al. Infection-induced colitis in mice causes dynamic and tissue-specific changes in stress response and DNA damage leading to colon cancer. Proc Natl Acad Sci U S A. 2012;109:E1820-9 pubmed publisher
    b>Helicobacter hepaticus-infected Rag2(-/-) mice emulate many aspects of human inflammatory bowel disease, including the development of colitis and colon cancer...
  8. Ge Z, Sterzenbach T, Whary M, Rickman B, Rogers A, Shen Z, et al. Helicobacter hepaticus HHGI1 is a pathogenicity island associated with typhlocolitis in B6.129-IL10 tm1Cgn mice. Microbes Infect. 2008;10:726-33 pubmed publisher
    b>Helicobacter hepaticus strain 3B1 (H. hepaticus) contains a genomic island of approximately 71 kb, HHGI1, with some of the common features shared among known bacterial pathogenicity islands...
  9. Okoli A, Fox E, Raftery M, Mendz G. Effects of Helicobacter hepaticus on the proteome of HEp-2 cells. Antonie Van Leeuwenhoek. 2007;92:289-300 pubmed
    b>Helicobacter hepaticus infects the bowel and biliary tree of several animals, producing inflammation. Colonisation of mouse livers can induce hepatocellular carcinomas. The effects of H...

More Information

Publications64

  1. Young V, Knox K, Pratt J, Cortez J, Mansfield L, Rogers A, et al. In vitro and in vivo characterization of Helicobacter hepaticus cytolethal distending toxin mutants. Infect Immun. 2004;72:2521-7 pubmed
    b>Helicobacter hepaticus expresses a member of the cytolethal distending toxin (CDT) family of bacterial cytotoxins. To investigate the role of CDT in the pathogenesis of H...
  2. Rogers A, Boutin S, Whary M, Sundina N, Ge Z, Cormier K, et al. Progression of chronic hepatitis and preneoplasia in Helicobacter hepaticus-infected A/JCr mice. Toxicol Pathol. 2004;32:668-77 pubmed
    b>Helicobacter hepaticus infection induces sustained inflammation and carcinoma of the liver in A/JCr mice, and serves as a model of human cancers associated with viral hepatitis and H. pylorichronic gastritis...
  3. Erdman S, Rao V, Poutahidis T, Ihrig M, Ge Z, Feng Y, et al. CD4(+)CD25(+) regulatory lymphocytes require interleukin 10 to interrupt colon carcinogenesis in mice. Cancer Res. 2003;63:6042-50 pubmed
    ..to inhibit carcinogenesis, 129/SvEv Rag-2-deficient mice were inoculated by gastric gavage with Helicobacter hepaticus, an enteric bacterial pathogen of mice...
  4. Ge Z, Feng Y, Whary M, Nambiar P, Xu S, Ng V, et al. Cytolethal distending toxin is essential for Helicobacter hepaticus colonization in outbred Swiss Webster mice. Infect Immun. 2005;73:3559-67 pubmed
    b>Helicobacter hepaticus, which induces chronic hepatitis and typhlocolitis in susceptible mouse strains, produces a cytolethal distending toxin (CDT) consisting of CdtA, CdtB, and CdtC. A cdtB-deficient H...
  5. Murakami K, Takahashi R, Ono M, Watanabe K, Okimoto T, Kodama M, et al. Serodiagnosis of Helicobacter hepaticus infection in patients with liver and gastrointestinal diseases: western blot analysis and ELISA using a highly specific monoclonal antibody for H. hepaticus antigen. J Gastroenterol. 2011;46:1120-6 pubmed publisher
    b>Helicobacter hepaticus infection might be associated with liver and biliary tract diseases. To investigate its pathogenic role, the properties of anti-H. hepaticus serum antibody in patients with liver and diseases were elucidated.
  6. Kuehl C, Wood H, Marsh T, Schmidt T, Young V. Colonization of the cecal mucosa by Helicobacter hepaticus impacts the diversity of the indigenous microbiota. Infect Immun. 2005;73:6952-61 pubmed
    ..of the cecal mucosa of Helicobacter-free mice following experimental infection with the pathogen Helicobacter hepaticus. Two days after infection, H...
  7. Nagamine C, Sohn J, Rickman B, Rogers A, Fox J, Schauer D. Helicobacter hepaticus infection promotes colon tumorigenesis in the BALB/c-Rag2(-/-) Apc(Min/+) mouse. Infect Immun. 2008;76:2758-66 pubmed publisher
    ..We investigated the effect of the enterohepatic bacterial pathogen Helicobacter hepaticus on liver and intestine tumorigenesis in BALB-RagMin mice. H...
  8. Mandell L, Moran A, Cocchiarella A, Houghton J, Taylor N, Fox J, et al. Intact gram-negative Helicobacter pylori, Helicobacter felis, and Helicobacter hepaticus bacteria activate innate immunity via toll-like receptor 2 but not toll-like receptor 4. Infect Immun. 2004;72:6446-54 pubmed
    ..Our studies suggest that TLR2 may be the dominant innate immune receptor for recognition of gastrointestinal Helicobacter species...
  9. Ge Z, Lee A, Whary M, Rogers A, Maurer K, Taylor N, et al. Helicobacter hepaticus urease is not required for intestinal colonization but promotes hepatic inflammation in male A/JCr mice. Microb Pathog. 2008;45:18-24 pubmed publisher
    ..In this study, we generated a urease-deficient, isogenic mutant (HhureNT9) of Helicobacter hepaticus 3B1 (Hh 3B1), an EHS that possesses a urease gene cluster similar to that of H. pylori...
  10. Erdman S, Rao V, Poutahidis T, Rogers A, Taylor C, Jackson E, et al. Nitric oxide and TNF-alpha trigger colonic inflammation and carcinogenesis in Helicobacter hepaticus-infected, Rag2-deficient mice. Proc Natl Acad Sci U S A. 2009;106:1027-32 pubmed publisher
    ..Infection of Rag2(-/-) mice with Helicobacter hepaticus led to accumulation of macrophages and neutrophils in the colon, a process temporally related to up-..
  11. Eppinger M, Baar C, Raddatz G, Huson D, Schuster S. Comparative analysis of four Campylobacterales. Nat Rev Microbiol. 2004;2:872-85 pubmed
    ..species - two pathogens of humans, Helicobacter pylori and Campylobacter jejuni, as well as Helicobacter hepaticus, which is associated with liver cancer in rodents, and the non-pathogenic commensal species, Wolinella ..
  12. Boutin S, Rogers A, Shen Z, Fry R, Love J, Nambiar P, et al. Hepatic temporal gene expression profiling in Helicobacter hepaticus-infected A/JCr mice. Toxicol Pathol. 2004;32:678-93 pubmed
    b>Helicobacter hepaticus infection of A/JCr mice is a model of infectious liver cancer. We monitored hepatic global gene expression profiles in H...
  13. Garcia A, Ihrig M, Fry R, Feng Y, Xu S, Boutin S, et al. Genetic susceptibility to chronic hepatitis is inherited codominantly in Helicobacter hepaticus-infected AB6F1 and B6AF1 hybrid male mice, and progression to hepatocellular carcinoma is linked to hepatic expression of lipogenic genes and immune funct. Infect Immun. 2008;76:1866-76 pubmed publisher
    b>Helicobacter hepaticus causes hepatitis in susceptible strains of mice. Previous studies indicated that A/JCr mice are susceptible and C57BL/6NCr mice are resistant to H. hepaticus-induced hepatitis...
  14. Alyamani E, Brandt P, Pena J, Major A, Fox J, Suerbaum S, et al. Helicobacter hepaticus catalase shares surface-predicted epitopes with mammalian catalases. Microbiology. 2007;153:1006-16 pubmed
    b>Helicobacter hepaticus colonizes the murine intestine and has been associated with hepatic inflammation and neoplasia in susceptible mouse strains...
  15. Ge Z, Feng Y, Taylor N, Ohtani M, Polz M, Schauer D, et al. Colonization dynamics of altered Schaedler flora is influenced by gender, aging, and Helicobacter hepaticus infection in the intestines of Swiss Webster mice. Appl Environ Microbiol. 2006;72:5100-3 pubmed
    ..Intestinal colonization levels of the eight ASF strains in outbred Swiss Webster mice with or without Helicobacter hepaticus infection were characterized by real-time quantitative PCR...
  16. Mehta N, Benoit S, Mysore J, Sousa R, Maier R. Helicobacter hepaticus hydrogenase mutants are deficient in hydrogen-supported amino acid uptake and in causing liver lesions in A/J mice. Infect Immun. 2005;73:5311-8 pubmed
    b>Helicobacter hepaticus, a causative agent of chronic hepatitis and hepatocellular carcinoma in mice, expresses a nickel-containing hydrogen-oxidizing hydrogenase enzyme...
  17. Hong Y, Wang G, Maier R. Helicobacter hepaticus Dps protein plays an important role in protecting DNA from oxidative damage. Free Radic Res. 2006;40:597-605 pubmed
    ..Dps in the enterohepatic pathogen, Helicobacter hepaticus is characterized and a H. hepaticus dps mutant was generated by insertional mutagenesis...
  18. Pena J, Rogers A, Ge Z, Ng V, Li S, Fox J, et al. Probiotic Lactobacillus spp. diminish Helicobacter hepaticus-induced inflammatory bowel disease in interleukin-10-deficient mice. Infect Immun. 2005;73:912-20 pubmed
    ..probiotic lactobacilli were selected in vitro for their ability to inhibit TNF-alpha secretion by Helicobacter hepaticus-stimulated macrophages...
  19. Benoit S, Seshadri S, Lamichhane Khadka R, Maier R. Helicobacter hepaticus NikR controls urease and hydrogenase activities via the NikABDE and HH0418 putative nickel import proteins. Microbiology. 2013;159:136-46 pubmed publisher
    b>Helicobacter hepaticus open reading frame HH0352 was identified as a nickel-responsive regulator NikR. The gene was disrupted by insertion of an erythromycin resistance cassette. The H...
  20. Avenaud P, Castroviejo M, Claret S, Rosenbaum J, Megraud F, Menard A. Expression and activity of the cytolethal distending toxin of Helicobacter hepaticus. Biochem Biophys Res Commun. 2004;318:739-45 pubmed
    b>Helicobacter hepaticus, a causal agent of hepatocarcinoma in mice, exhibits a cytolethal distending toxin activity...
  21. Pratt J, Sachen K, Wood H, Eaton K, Young V. Modulation of host immune responses by the cytolethal distending toxin of Helicobacter hepaticus. Infect Immun. 2006;74:4496-504 pubmed
    Persistent murine infection with Helicobacter hepaticus leads to chronic gastrointestinal inflammation and neoplasia in susceptible strains...
  22. Ge Z, Rogers A, Feng Y, Lee A, Xu S, Taylor N, et al. Bacterial cytolethal distending toxin promotes the development of dysplasia in a model of microbially induced hepatocarcinogenesis. Cell Microbiol. 2007;9:2070-80 pubmed
    ..In this study, infection of A/JCr mice with an isogenic mutant of Helicobacter hepaticus lacking CDT activity (CDT mutant) induced chronic hepatitis comparable to wild-type H...
  23. Hong Y, Wang G, Maier R. The NADPH quinone reductase MdaB confers oxidative stress resistance to Helicobacter hepaticus. Microb Pathog. 2008;44:169-74 pubmed
    An mdaB mutant strain in a quinone reductase (MdaB) of Helicobacter hepaticus type strain ATCC51449 was constructed by insertional mutagenesis, and the MdaB protein was purified and compared to the Helicobacter pylori enzyme...
  24. Tomczak M, Gadjeva M, Wang Y, Brown K, Maroulakou I, Tsichlis P, et al. Defective activation of ERK in macrophages lacking the p50/p105 subunit of NF-kappaB is responsible for elevated expression of IL-12 p40 observed after challenge with Helicobacter hepaticus. J Immunol. 2006;176:1244-51 pubmed
    b>Helicobacter hepaticus is an enterohepatic Helicobacter species that induces lower bowel inflammation in susceptible mouse strains, including those lacking the p50/p105 subunit of NF-kappaB. H...
  25. Fox J, Ge Z, Whary M, Erdman S, Horwitz B. Helicobacter hepaticus infection in mice: models for understanding lower bowel inflammation and cancer. Mucosal Immunol. 2011;4:22-30 pubmed publisher
    Pioneering work in the 1990s first linked a novel microaerobic bacterium, Helicobacter hepaticus, with chronic active hepatitis and inflammatory bowel disease in several murine models. Targeted H...
  26. Pradhan S. Study of Helicobacter hepaticus in gallbladders with cholelithiasis and its sensitivity pattern. Kathmandu Univ Med J (KUMJ). 2009;7:125-8 pubmed
    ..The natural history of gallstone development is unknown. Bacteria are found in high concentration in bile and stone. It is difficult to ascertain whether bacterial infection of the bile arose before stone formation or vice versa...
  27. Bartonickova L, Sterzenbach T, Nell S, Kops F, Schulze J, Venzke A, et al. Hcp and VgrG1 are secreted components of the Helicobacter hepaticus type VI secretion system and VgrG1 increases the bacterial colitogenic potential. Cell Microbiol. 2013;15:992-1011 pubmed publisher
    The enterohepatic Epsilonproteobacterium Helicobacter hepaticus persistently colonizes the intestine of mice and causes chronic inflammatory symptoms in susceptible mouse strains...
  28. Whary M, Taylor N, Feng Y, Ge Z, Muthupalani S, Versalovic J, et al. Lactobacillus reuteri promotes Helicobacter hepaticus-associated typhlocolitis in gnotobiotic B6.129P2-IL-10(tm1Cgn) (IL-10(-/-) ) mice. Immunology. 2011;133:165-78 pubmed publisher
    To model inflammatory bowel disease, we assessed infection with Helicobacter hepaticus 3B1 (ATCC 51449) and a potential probiotic Lactobacillus reuteri (ATCC PTA-6475) in gnotobiotic B6.129P2-IL-10(tm1Cgn) (IL-10(-/-) ) mice...
  29. Shimoyama T, Takahashi R, Abe D, Mizuki I, Endo T, Fukuda S. Serological analysis of Helicobacter hepaticus infection in patients with biliary and pancreatic diseases. J Gastroenterol Hepatol. 2010;25 Suppl 1:S86-9 pubmed publisher
    Infection with Helicobacter hepaticus has been associated with development of hepatocellular carcinoma and gallstones in animal models. In humans, however, the association of H...
  30. Hamada T, Yokota K, Ayada K, Hirai K, Kamada T, Haruma K, et al. Detection of Helicobacter hepaticus in human bile samples of patients with biliary disease. Helicobacter. 2009;14:545-51 pubmed publisher
    ..Some enterohepatic Helicobacters have been associated with inflammatory bowel disease or liver disease in mice. However the association of these bacteria with human diseases remains unknown...
  31. Mazmanian S, Round J, Kasper D. A microbial symbiosis factor prevents intestinal inflammatory disease. Nature. 2008;453:620-5 pubmed publisher
    ..the prominent human symbiont Bacteroides fragilis protects animals from experimental colitis induced by Helicobacter hepaticus, a commensal bacterium with pathogenic potential...
  32. Hue S, Ahern P, Buonocore S, Kullberg M, Cua D, McKenzie B, et al. Interleukin-23 drives innate and T cell-mediated intestinal inflammation. J Exp Med. 2006;203:2473-83 pubmed
    ..These results newly identify IL-23 as a driver of innate immune pathology in the intestine and suggest that selective targeting of IL-23 represents an attractive therapeutic approach in human IBD...
  33. Boutin S, Shen Z, Rogers A, Feng Y, Ge Z, Xu S, et al. Different Helicobacter hepaticus strains with variable genomic content induce various degrees of hepatitis. Infect Immun. 2005;73:8449-52 pubmed
    A 70-kb genomic island (HHGI1) in Helicobacter hepaticus strain ATCC 51449 is a putative pathogenicity island (PAI). To determine the in vivo relevance of this PAI, we inoculated A/JCr mice with one of three strains of H...
  34. Kullberg M, Jankovic D, Feng C, Hue S, Gorelick P, McKenzie B, et al. IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis. J Exp Med. 2006;203:2485-94 pubmed
    ..We have analyzed the role of IL-12 versus IL-23 in two models of Helicobacter hepaticus-triggered T cell-dependent colitis, one involving anti-IL-10R monoclonal antibody treatment of infected T ..
  35. Maggio Price L, Bielefeldt Ohmann H, Treuting P, Iritani B, Zeng W, Nicks A, et al. Dual infection with Helicobacter bilis and Helicobacter hepaticus in p-glycoprotein-deficient mdr1a-/- mice results in colitis that progresses to dysplasia. Am J Pathol. 2005;166:1793-806 pubmed
    ..This animal model may have particular relevance to human IBD and colorectal cancer because certain human MDR1 polymorphisms have been linked to ulcerative colitis and increased risk for colorectal cancer...
  36. Chow J, Mazmanian S. A pathobiont of the microbiota balances host colonization and intestinal inflammation. Cell Host Microbe. 2010;7:265-76 pubmed publisher
    ..Here we reveal a protective role for the T6SS of Helicobacter hepaticus, a Gram-negative bacterium of the intestinal microbiota. H...
  37. Rao V, Poutahidis T, Ge Z, Nambiar P, Boussahmain C, Wang Y, et al. Innate immune inflammatory response against enteric bacteria Helicobacter hepaticus induces mammary adenocarcinoma in mice. Cancer Res. 2006;66:7395-400 pubmed
    ..we report that infecting Rag2-deficient C57BL/6 Apc(Min/+) mice with an intestinal bacterial pathogen, Helicobacter hepaticus, significantly promotes mammary carcinoma in females and enhances intestinal adenoma multiplicity by a ..
  38. Pradhan S, Dali S. Relation between gallbladder neoplasm and Helicobacter hepaticus infection. Kathmandu Univ Med J (KUMJ). 2004;2:331-5 pubmed
    The main objective of this study was to see the various histopathological changes in the gallbladder with cholelithiasis and to correlate them with Helicobacter hepaticus infection.
  39. Belzer C, Stoof J, Beckwith C, Kuipers E, Kusters J, van Vliet A. Differential regulation of urease activity in Helicobacter hepaticus and Helicobacter pylori. Microbiology. 2005;151:3989-95 pubmed publisher
    b>Helicobacter hepaticus is a pathogen of rodents, which causes diverse enteric and hepatic inflammatory diseases and malignancies...
  40. Singletary K, Kloster C, Baker D. Optimal age at fostering for derivation of Helicobacter hepaticus-free mice. Comp Med. 2003;53:259-64 pubmed
    b>Helicobacter hepaticus is well established as an unwanted variable in laboratory rodent colonies. Historically, cesarean section and embryo transfer have been used to derive Helicobacter-free mouse colonies...
  41. Jeong E, Lee K, Heo S, Seo J, Choi Y. Triplex PCR for the simultaneous detection of Pseudomonas aeruginosa, Helicobacter hepaticus, and Salmonella typhimurium. Exp Anim. 2011;60:65-70 pubmed
    ..PCR method for the direct detection of three common gastroenteric bacteria, Pseudomonas aeruginosa, Helicobacter hepaticus, and Salmonella typhimurium...
  42. Yang I, Eibach D, Kops F, Brenneke B, Woltemate S, Schulze J, et al. Intestinal microbiota composition of interleukin-10 deficient C57BL/6J mice and susceptibility to Helicobacter hepaticus-induced colitis. PLoS ONE. 2013;8:e70783 pubmed publisher
    The mouse pathobiont Helicobacter hepaticus can induce typhlocolitis in interleukin-10-deficient mice, and H...
  43. Tomczak M, Erdman S, Davidson A, Wang Y, Nambiar P, Rogers A, et al. Inhibition of Helicobacter hepaticus-induced colitis by IL-10 requires the p50/p105 subunit of NF-kappa B. J Immunol. 2006;177:7332-9 pubmed
    Defects within the innate immune system sensitize NF-kappaB-deficient (p50(-/-); p65(+/-)) mice to Helicobacter hepaticus (Hh)-induced colitis...
  44. Boulard O, Kirchberger S, Royston D, Maloy K, Powrie F. Identification of a genetic locus controlling bacteria-driven colitis and associated cancer through effects on innate inflammation. J Exp Med. 2012;209:1309-24 pubmed publisher
    ..We report the identification of a genetic interval Hiccs that regulates Helicobacter hepaticus-induced colitis and associated cancer susceptibility in a 129.RAG(-/-) mouse model. The 1...
  45. Büchler G, Wos Oxley M, Smoczek A, Zschemisch N, Neumann D, Pieper D, et al. Strain-specific colitis susceptibility in IL10-deficient mice depends on complex gut microbiota-host interactions. Inflamm Bowel Dis. 2012;18:943-54 pubmed publisher
    ..The aim of this study was to determine the impact of microbiota on this differential colitis susceptibility using a Helicobacter hepaticus infection model.
  46. Garcia A, Zeng Y, Muthupalani S, Ge Z, Potter A, Mobley M, et al. Helicobacter hepaticus--induced liver tumor promotion is associated with increased serum bile acid and a persistent microbial-induced immune response. Cancer Res. 2011;71:2529-40 pubmed publisher
    ..or without the tumor initiator diethylnitrosamine (DEN) at 5 weeks of age and then orally inoculated with Helicobacter hepaticus (Hh) or sterile media at 8 weeks of age...
  47. Buonocore S, Ahern P, Uhlig H, Ivanov I, Littman D, Maloy K, et al. Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology. Nature. 2010;464:1371-5 pubmed publisher
    ..These results identify a previously unrecognized IL-23-responsive innate lymphoid population that mediates intestinal immune pathology and may therefore represent a target in inflammatory bowel disease. ..
  48. Okoli A, Wilkins M, Raftery M, Mendz G. Response of Helicobacter hepaticus to bovine bile. J Proteome Res. 2010;9:1374-84 pubmed publisher
    b>Helicobacter hepaticus is an enterohepatic bacterium associated with inflammatory bowel disease in children and causes severe hepatobiliary disorders in mice. To elucidate the molecular response of H...
  49. Sterzenbach T, Bartonickova L, Behrens W, Brenneke B, Schulze J, Kops F, et al. Role of the Helicobacter hepaticus flagellar sigma factor FliA in gene regulation and murine colonization. J Bacteriol. 2008;190:6398-408 pubmed publisher
    The enterohepatic Helicobacter species Helicobacter hepaticus colonizes the murine intestinal and hepatobiliary tract and is associated with chronic intestinal inflammation, gall stone formation, hepatitis, and hepatocellular carcinoma...
  50. Krishnan N, Doster A, Duhamel G, Becker D. Characterization of a Helicobacter hepaticus putA mutant strain in host colonization and oxidative stress. Infect Immun. 2008;76:3037-44 pubmed publisher
    b>Helicobacter hepaticus is a gram-negative, spiral-shaped microaerophilic bacterium associated with chronic intestinal infection leading to hepatitis and colonic and hepatic carcinomas in susceptible strains of mice...
  51. Livingston R, Myles M, Livingston B, Criley J, Franklin C. Sex influence on chronic intestinal inflammation in Helicobacter hepaticus-infected A/JCr mice. Comp Med. 2004;54:301-8 pubmed
    b>Helicobacter hepaticus is a bacterial pathogen of mice that has been reported to cause chronic intestinal inflammation in A/JCr, germfree Swiss Webster, and immunodeficient mice...
  52. Kullberg M. Immunology: soothing intestinal sugars. Nature. 2008;453:602-4 pubmed publisher
  53. Belzer C, van Schendel B, Kuipers E, Kusters J, van Vliet A. Iron-responsive repression of urease expression in Helicobacter hepaticus is mediated by the transcriptional regulator Fur. Infect Immun. 2007;75:745-52 pubmed
    ..b>Helicobacter hepaticus is a urease-positive pathogen that colonizes the intestinal and hepatobiliary tracts of rodents...
  54. Liyanage N, Manthey K, Dassanayake R, Kuszynski C, Oakley G, Duhamel G. Helicobacter hepaticus cytolethal distending toxin causes cell death in intestinal epithelial cells via mitochondrial apoptotic pathway. Helicobacter. 2010;15:98-107 pubmed publisher
    b>Helicobacter hepaticus, the prototype for enterohepatic Helicobacter species, colonizes the lower intestinal and hepatobiliary tracts of mice and causes typhlocolitis, hepatitis, and hepatocellular carcinoma in susceptible mouse strains...
  55. Thomson N, Sebaihia M, Cerdeno Tárraga A, Bentley S, Crossman L, Parkhill J. The value of comparison. Nat Rev Microbiol. 2003;1:11-2 pubmed
    ..Several genome sequences published recently indicate the value of comparisons at the genomic level...