helicobacter felis

Summary

Summary: A species of HELICOBACTER that colonizes in the STOMACH of laboratory MICE; CATS; and DOGS. It is associated with lymphoid follicular hyperplasia and mild GASTRITIS in CATS.

Top Publications

  1. Drakes M, Czinn S, Blanchard T. Regulation of murine dendritic cell immune responses by Helicobacter felis antigen. Infect Immun. 2006;74:4624-33 pubmed
    ..After treatment with Helicobacter felis Ag, DC were polarized to secrete interleukin-6 as the dominant cytokine...
  2. Alam M, Kurtz C, Rowlett R, Reuter B, Wiznerowicz E, Das S, et al. CD73 is expressed by human regulatory T helper cells and suppresses proinflammatory cytokine production and Helicobacter felis-induced gastritis in mice. J Infect Dis. 2009;199:494-504 pubmed publisher
    ..investigated the expression of CD39 and CD73 on human T helper (Th) cells and the role of CD73 in regulating Helicobacter felis-induced gastritis and colonization...
  3. Every A, Chionh Y, Skene C, McGuckin M, Sutton P. Muc1 limits Helicobacter felis binding to gastric epithelial cells but does not limit colonization and gastric pathology following infection. Helicobacter. 2008;13:489-93 pubmed publisher
    ..We therefore examined the importance of Muc1 on the pathogenesis of Helicobacter felis, believed not to adhere to the murine mucosa.
  4. Ihrig M, Whary M, Dangler C, Fox J. Gastric helicobacter infection induces a Th2 phenotype but does not elevate serum cholesterol in mice lacking inducible nitric oxide synthase. Infect Immun. 2005;73:1664-70 pubmed
    Persistent Helicobacter felis infection in (C57BL/6 x 129SvEv)F1 mice induces chronic gastritis. Expression of inducible nitric oxide synthase (iNOS) is upregulated in response to Helicobacter infection...
  5. de Bock M, D Herde K, Duchateau L, Hellemans A, Decostere A, Haesebrouck F, et al. The effect of Helicobacter felis and Helicobacter bizzozeronii on the gastric mucosa in Mongolian gerbils: a sequential pathological study. J Comp Pathol. 2006;135:226-36 pubmed
    ..The mechanism by which H. felis induces PC necrosis and apoptosis remains unclear. The observed flagellar contact and NF-kappaB activation may play an important role in H. felis-associated inflammation...
  6. Hasegawa S, Nishikawa S, Miura T, Saito Y, Madarame H, Sekikawa K, et al. Tumor necrosis factor-alpha is required for gastritis induced by Helicobacter felis infection in mice. Microb Pathog. 2004;37:119-24 pubmed
    ..felis infection as IFN-gamma and that an interaction between TNF-alpha and IFN-gamma might be required in pathogenesis of gastritis induced by Helicobacter infection...
  7. Houghton J, Stoicov C, Nomura S, Rogers A, Carlson J, Li H, et al. Gastric cancer originating from bone marrow-derived cells. Science. 2004;306:1568-71 pubmed
    ..These findings suggest that epithelial cancers can originate from marrow-derived sources and thus have broad implications for the multistep model of cancer progression...
  8. Fukui T, Kishimoto M, Nakajima A, Yamashina M, Nakayama S, Kusuda T, et al. The specific linker phosphorylation of Smad2/3 indicates epithelial stem cells in stomach; particularly increasing in mucosae of Helicobacter-associated gastritis. J Gastroenterol. 2011;46:456-68 pubmed publisher
    ..However, the lack of useful markers has hindered studies of their origin. We explored whether Smad2/3, phosphorylated at specific linker threonine residues (pSmad2/3L-Thr), could serve as a marker for stem cells...
  9. Van den Bulck K, Decostere A, Gruntar I, Baele M, Krt B, Ducatelle R, et al. In vitro antimicrobial susceptibility testing of Helicobacter felis, H. bizzozeronii, and H. salomonis. Antimicrob Agents Chemother. 2005;49:2997-3000 pubmed
    The susceptibilities of Helicobacter felis (15 strains), H. bizzozeronii (7 strains), and H. salomonis (3 strains) to 10 antimicrobial agents were investigated by determination of the MIC using the agar dilution method...

More Information

Publications86

  1. Kawasaki K, Nishio A, Nakamura H, Uchida K, Fukui T, Ohana M, et al. Helicobacter felis-induced gastritis was suppressed in mice overexpressing thioredoxin-1. Lab Invest. 2005;85:1104-17 pubmed
    ..We investigated the roles of TRX-1 in the host defense mechanism against Helicobacter felis (H. felis) infection...
  2. De Bock M, Decostere A, Hellemans A, Haesebrouck F, Ducatelle R. Helicobacter felis and Helicobacter bizzozeronii induce gastric parietal cell loss in Mongolian gerbils. Microbes Infect. 2006;8:503-10 pubmed
    ..Approximately 50% of these are caused by helicobacters commonly found in dogs and cats, including Helicobacter felis, Helicobacter bizzozeronii and H. salomonis...
  3. Burkitt M, Williams J, Duckworth C, O Hara A, Hanedi A, Varro A, et al. Signaling mediated by the NF-?B sub-units NF-?B1, NF-?B2 and c-Rel differentially regulate Helicobacter felis-induced gastric carcinogenesis in C57BL/6 mice. Oncogene. 2013;32:5563-73 pubmed publisher
    ..To investigate this C57BL/6, Nfkb1(-/-), Nfkb2(-/-) and c-Rel(-/-) mice were infected with Helicobacter felis for 6 weeks or 12 months...
  4. Mandell L, Moran A, Cocchiarella A, Houghton J, Taylor N, Fox J, et al. Intact gram-negative Helicobacter pylori, Helicobacter felis, and Helicobacter hepaticus bacteria activate innate immunity via toll-like receptor 2 but not toll-like receptor 4. Infect Immun. 2004;72:6446-54 pubmed
    ..Our studies suggest that TLR2 may be the dominant innate immune receptor for recognition of gastrointestinal Helicobacter species...
  5. Stoicov C, Whary M, Rogers A, Lee F, Klucevsek K, Li H, et al. Coinfection modulates inflammatory responses and clinical outcome of Helicobacter felis and Toxoplasma gondii infections. J Immunol. 2004;173:3329-36 pubmed
    ..Using the BALB/c strain of mice, we show that Toxoplasma gondii infection in a host infected with Helicobacter felis alters the natural outcome of T...
  6. Tu S, Bhagat G, Cui G, Takaishi S, Kurt Jones E, Rickman B, et al. Overexpression of interleukin-1beta induces gastric inflammation and cancer and mobilizes myeloid-derived suppressor cells in mice. Cancer Cell. 2008;14:408-19 pubmed publisher
    ..These results demonstrate that pathologic elevation of a single proinflammatory cytokine may be sufficient to induce neoplasia and provide a direct link between IL-1beta, MDSCs, and carcinogenesis...
  7. Stoicov C, Fan X, Liu J, Bowen G, Whary M, Kurt Jones E, et al. T-bet knockout prevents Helicobacter felis-induced gastric cancer. J Immunol. 2009;183:642-9 pubmed publisher
    ..this study, we used C57BL/6 mice to identify T-bet as a central regulator of the cytokine environment during Helicobacter felis infection. We infected male and female C57BL/6 and C57BL/6-T-bet knockout (KO) litter mates with H...
  8. Schmitz J, Durham C, Schoeb T, Soltau T, Wolf K, Tanner S, et al. Helicobacter felis--associated gastric disease in microbiota-restricted mice. J Histochem Cytochem. 2011;59:826-41 pubmed publisher
    ..ASF) to evaluate the role of nonhelicobacter gastric microbiota in disease development after Helicobacter felis infection. Despite similar histological changes, H. felis persisted in B6.ASF stomachs, while H...
  9. Gøbel R, Symonds E, Kritas S, Butler R, Tran C. Helicobacter felis infection causes an acute iron deficiency in nonpregnant and pregnant mice. Helicobacter. 2006;11:529-32 pubmed
    ..The role of Helicobacter pylori infection in iron deficiency during pregnancy is limited. The aim of the present study was to assess the relationship between Helicobacter infection and levels of iron stores in pregnant mice...
  10. Duckworth C, Clyde D, Pritchard D. CD24 is expressed in gastric parietal cells and regulates apoptosis and the response to Helicobacter felis infection in the murine stomach. Am J Physiol Gastrointest Liver Physiol. 2012;303:G915-26 pubmed publisher
    ..We have investigated the effects of CD24 deletion on gastric responses to Helicobacter felis infection and ?-irradiation using CD24-null mice...
  11. Obonyo M, Rickman B, Guiney D. Effects of myeloid differentiation primary response gene 88 (MyD88) activation on Helicobacter infection in vivo and induction of a Th17 response. Helicobacter. 2011;16:398-404 pubmed publisher
    ..We provide evidence showing that MyD88-dependent signaling is required for the host to induce a Th17 response for the control of Helicobacter infection. ..
  12. Arnold I, Zigova Z, Holden M, Lawley T, Rad R, Dougan G, et al. Comparative whole genome sequence analysis of the carcinogenic bacterial model pathogen Helicobacter felis. Genome Biol Evol. 2011;3:302-8 pubmed publisher
    The gram-negative bacterium Helicobacter felis naturally colonizes the gastric mucosa of dogs and cats. Due to its ability to persistently infect laboratory mice, H...
  13. Fritz E, Slavik T, Delport W, Olivier B, van der Merwe S. Incidence of Helicobacter felis and the effect of coinfection with Helicobacter pylori on the gastric mucosa in the African population. J Clin Microbiol. 2006;44:1692-6 pubmed
    Helicobacter pylori and Helicobacter felis are two of the Helicobacter spp. that infect humans. H. pylori has been linked to significant gastric pathology. Coinfection with Helicobacter spp...
  14. Baele M, Van den Bulck K, Decostere A, Vandamme P, Hänninen M, Ducatelle R, et al. Multiplex PCR assay for differentiation of Helicobacter felis, H. bizzozeronii, and H. salomonis. J Clin Microbiol. 2004;42:1115-22 pubmed
    b>Helicobacter felis, Helicobacter bizzozeronii, and Helicobacter salomonis are frequently found in the gastric mucous membrane of dogs and cats. These large spiral organisms are phylogenetically highly related to each other...
  15. de Bock M, Decostere A, Van den Bulck K, Baele M, Duchateau L, Haesebrouck F, et al. The inflammatory response in the mouse stomach to Helicobacter bizzozeronii, Helicobacter salomonis and two Helicobacter felis Strains. J Comp Pathol. 2005;133:83-91 pubmed
    ..H. bizzozeronii differed from the two H. felis strains in producing less striking pathological changes in mice. Of the two H. felis strains, ATCC 49179 produced the more severe inflammatory changes in SJL mice...
  16. Cai X, Carlson J, Stoicov C, Li H, Wang T, Houghton J. Helicobacter felis eradication restores normal architecture and inhibits gastric cancer progression in C57BL/6 mice. Gastroenterology. 2005;128:1937-52 pubmed
    ..This study examined the effects of eradication therapy on inflammation, atrophy, metaplasia, dysplasia, and cancer progression...
  17. Wüppenhorst N, von Loewenich F, Hobmaier B, Vetter Knoll M, Mohadjer S, Kist M. Culture of a gastric non-Helicobacter pylori Helicobacter from the stomach of a 14-year-old girl. Helicobacter. 2013;18:1-5 pubmed publisher
    b>Helicobacter felis belongs to the fastidious gastric non-Helicobacter pylori helicobacter species that are typically found in the stomach of cats and dogs...
  18. El Zaatari M, Kao J, Tessier A, Bai L, Hayes M, Fontaine C, et al. Gli1 deletion prevents Helicobacter-induced gastric metaplasia and expansion of myeloid cell subsets. PLoS ONE. 2013;8:e58935 pubmed publisher
  19. Floch P, Izotte J, Guillemaud J, Sifré E, Costet P, Rousseau B, et al. A New Animal Model of Gastric Lymphomagenesis: APRIL Transgenic Mice Infected by Helicobacter Species. Am J Pathol. 2017;187:1473-1484 pubmed publisher
    ..Wild-type (WT) and APRIL Tg mice were infected with Helicobacter felis and Helicobacter pylori and compared with noninfected animals...
  20. Burkitt M, Duckworth C, Williams J, Pritchard D. Helicobacter pylori-induced gastric pathology: insights from in vivo and ex vivo models. Dis Model Mech. 2017;10:89-104 pubmed publisher
    ..pylori, Helicobacter felis and Helicobacter suis in rodents and large animals...
  21. Hellemans A, Decostere A, Duchateau L, de Bock M, Haesebrouck F, Ducatelle R. Protective immunization against "Candidatus Helicobacter suis" with heterologous antigens of H. pylori and H. felis. Vaccine. 2006;24:2469-76 pubmed
    ..were vaccinated intranasally or subcutaneously with whole bacterial cell lysate of Helicobacter pylori or Helicobacter felis and subsequently challenge infected with "Candidatus H. suis"...
  22. Ferrero R, Ave P, Ndiaye D, Bambou J, Huerre M, Philpott D, et al. NF-kappaB activation during acute Helicobacter pylori infection in mice. Infect Immun. 2008;76:551-61 pubmed
    ..H. pylori and Helicobacter felis strains up-regulated the synthesis in mouse GECs of the NF-kappaB-dependent chemokines KC (CXCL1) and MIP-2 (..
  23. Moyat M, Mack M, Bouzourene H, Velin D. Role of Inflammatory Monocytes in Vaccine-Induced Reduction of Helicobacter felis Infection. Infect Immun. 2015;83:4217-28 pubmed publisher
    ..In this study, we evaluated the role of inflammatory monocytes in the vaccine-induced reduction of Helicobacter felis infection...
  24. Stoicov C, Li H, Liu J, Houghton J. Mesenchymal stem cells utilize CXCR4-SDF-1 signaling for acute, but not chronic, trafficking to gastric mucosal inflammation. Dig Dis Sci. 2013;58:2466-77 pubmed publisher
    ..Mouse culture-adapted MSC express CXCR4. Wild-type C57BL/6 mice infected with Helicobacter felis for 6 months or controls were given IV injections of CXCR4 knock-down MSC...
  25. Thomson M, Pritchard D, Boxall S, Abuderman A, Williams J, Varro A, et al. Gastric Helicobacter infection induces iron deficiency in the INS-GAS mouse. PLoS ONE. 2012;7:e50194 pubmed publisher
    ..INS-GAS mice were infected with Helicobacter felis for 3, 6 and 9 months...
  26. Said S, Barut G, Mansur N, Korkmaz A, Sayı Yazgan A. Bacterially activated B-cells drive T cell differentiation towards Tr1 through PD-1/PD-L1 expression. Mol Immunol. 2018;96:48-60 pubmed publisher
    ..Our results demonstrate that Helicobacter felis -stimulated IL-10- producing B cells (Hfstim- IL-10+ B) are composed of B10 and ..
  27. Xu J, Czinn S, Blanchard T. Maintenance of Helicobacter pylori cultures in agar stabs. Helicobacter. 2010;15:477-80 pubmed publisher
    ..H. pylori grown in agar stabs remains viable for prolonged periods of time without the need to subculture and may represent an improved method for storing H. pylori for infrequent use. ..
  28. Pellicano R, Astegiano M, Smedile A, Bonardi R, Morgando A, Repici A, et al. [Non-invasive diagnosis of Helicobacter pylori infection in the 2006 clinical practice]. Minerva Med. 2006;97:19-24 pubmed
    ..Confirmation of H. pylori eradication following treatment should be tested by UBT; the stool antigen assay is the alternative if the former is not available. ..
  29. Cai X, Stoicov C, Li H, Carlson J, Whary M, Fox J, et al. Overcoming Fas-mediated apoptosis accelerates Helicobacter-induced gastric cancer in mice. Cancer Res. 2005;65:10912-20 pubmed
    ..or wt/wt control mice, extending the life span of the lpr and ensuring a competent immune response to Helicobacter felis infection...
  30. Kawasaki K, Nishio A, Chiba T, Nakamura H. [Protective role of thioredoxin-1 in Helicobacter felis-induced gastritis]. Nihon Rinsho. 2005;63 Suppl 11:116-22 pubmed
  31. Marx J. Medicine. Bone marrow cells: the source of gastric cancer?. Science. 2004;306:1455-7 pubmed
  32. Takaishi S, Tu S, Dubeykovskaya Z, Whary M, Muthupalani S, Rickman B, et al. Gastrin is an essential cofactor for helicobacter-associated gastric corpus carcinogenesis in C57BL/6 mice. Am J Pathol. 2009;175:365-75 pubmed publisher
    We have previously described a synergistic interaction between hypergastrinemia and Helicobacter felis infection on gastric corpus carcinogenesis in FVB/N mice housed under specific-pathogen-free conditions...
  33. Takaishi S, Shibata W, Tomita H, Jin G, Yang X, Ericksen R, et al. In vivo analysis of mouse gastrin gene regulation in enhanced GFP-BAC transgenic mice. Am J Physiol Gastrointest Liver Physiol. 2011;300:G334-44 pubmed publisher
    ..were decreased by overnight fasting, octreotide (long-lasting somatostatin ortholog) infusion, and Helicobacter felis infection...
  34. Zavros Y, Rathinavelu S, Kao J, Todisco A, Del Valle J, Weinstock J, et al. Treatment of Helicobacter gastritis with IL-4 requires somatostatin. Proc Natl Acad Sci U S A. 2003;100:12944-9 pubmed
    ..Treatment of mice chronically infected with Helicobacter felis for 2 mo with the SOM analogue octreotide resolved the inflammation...
  35. Kiriya K, Watanabe N, Nishio A, Okazaki K, Kido M, Saga K, et al. Essential role of Peyer's patches in the development of Helicobacter-induced gastritis. Int Immunol. 2007;19:435-46 pubmed
    ..well-organized lymphoid organs except for PPs and intra-gastrically infected the resulting PP-null mice with Helicobacter felis. PP deficiency severely impaired both the development of T(h)1 cell-mediated gastritis induced by ..
  36. Jenks P, Jeremy A, Robinson P, Walker M, Crabtree J. Long-term infection with Helicobacter felis and inactivation of the tumour suppressor gene p53 cumulatively enhance the gastric mutation frequency in Big Blue transgenic mice. J Pathol. 2003;201:596-602 pubmed
    The aims of this study were to determine whether colonization with Helicobacter felis resulted in the accumulation of mutations within murine gastric tissue and whether the degree of genetic damage was increased by p53 deficiency...
  37. Kobayashi M, Lee H, Schaffer L, Gilmartin T, Head S, Takaishi S, et al. A distinctive set of genes is upregulated during the inflammation-carcinoma sequence in mouse stomach infected by Helicobacter felis. J Histochem Cytochem. 2007;55:263-74 pubmed
    ..pylori-related Helicobacter felis. Histological examination revealed that more than half of those mice developed invasive adenocarcinoma after ..
  38. Ng G, Every A, McGuckin M, Sutton P. Increased Helicobacter felis colonization in male 129/Sv mice fails to suppress gastritis. Gut Microbes. 2011;2:358-60 pubmed publisher
    ..pylori. Moreover, our demonstration that H. pylori but not H. felis can locally suppress inflammation in vivo may explain why H. felis infection induces superior levels of gastritis as compared with H. pylori infection of mice. ..
  39. Baudron C, Chambonnier L, Buissionnière A, Giese A, Macrez N, Cho Y, et al. An Eighteen-Month Helicobacter Infection Does Not Induce Amyloid Plaques or Neuroinflammation in Brains of Wild Type C57BL/6J Mice. J Alzheimers Dis. 2015;45:1045-50 pubmed
    ..For that, C57BL/6J mice were infected by oral gavage with H. pylori SS1 (n = 6) and Helicobacter felis (H...
  40. Shibata W, Sue S, Tsumura S, Ishii Y, Sato T, Kameta E, et al. Helicobacter-induced gastric inflammation alters the properties of gastric tissue stem/progenitor cells. BMC Gastroenterol. 2017;17:145 pubmed publisher
    ..mimicking gastric epithelial layer, and characterized the changes in epithelial cells after chronic Helicobacter felis infection. We used three mice model; 1) long-term H. felis infection, 2) H...
  41. Kenny S, Gamble J, Lyons S, Vlatkovic N, Dimaline R, Varro A, et al. Gastric expression of plasminogen activator inhibitor (PAI)-1 is associated with hyperphagia and obesity in mice. Endocrinology. 2013;154:718-26 pubmed publisher
    ..Infection of C57BL/6 mice with Helicobacter felis increased gastric abundance of PAI-1 and reduced the satiating effects of CCK8s, whereas the response to ..
  42. Piao S, Jin X, Yun B, Kim N, Cho H, Fukuda M, et al. Crystal structure and functional insight of HP0420-homolog from Helicobacter felis. Biochem Biophys Res Commun. 2010;394:940-6 pubmed publisher
    ..The crystal structure suggests that HF0420 has enzymatic activity that involves a conserved histidine residue at the end of the central alpha-helix. Subsequent biochemical studies provide clues to the function of HP0420 and HF0420...
  43. Stoicov C, Saffari R, Houghton J. Green tea inhibits Helicobacter growth in vivo and in vitro. Int J Antimicrob Agents. 2009;33:473-8 pubmed publisher
    ..In this study, we assessed the bactericidal and/or bacteriostatic effect of green tea against Helicobacter felis and H...
  44. Huhtinen H, Grönroos J, Uksila J, Grass D, Nevalainen T, Laine V. Experimental Helicobacter felis infection in transgenic mice expressing human group IIA phospholipase A2. Helicobacter. 2004;9:408-16 pubmed
    ..pylori infection. In animal experiments with Helicobacter felis, large variations in the severity of disease have been observed between different mouse strains infected ..
  45. Baele M, Pasmans F, Flahou B, Chiers K, Ducatelle R, Haesebrouck F. Non-Helicobacter pylori helicobacters detected in the stomach of humans comprise several naturally occurring Helicobacter species in animals. FEMS Immunol Med Microbiol. 2009;55:306-13 pubmed publisher
    ..Other NHPH that colonize the human stomach are Helicobacter felis, Helicobacter bizzozeronii, Helicobacter salomonis and 'Candidatus Helicobacter heilmannii'...
  46. Velin D, Bachmann D, Bouzourene H, Michetti P. Mast cells are critical mediators of vaccine-induced Helicobacter clearance in the mouse model. Gastroenterology. 2005;129:142-55 pubmed
    ..Despite the proven ability of immunization to prevent Helicobacter infection in mouse models, the precise mechanism of protection has remained elusive...
  47. Okumura T, Wang S, Takaishi S, Tu S, Ng V, Ericksen R, et al. Identification of a bone marrow-derived mesenchymal progenitor cell subset that can contribute to the gastric epithelium. Lab Invest. 2009;89:1410-22 pubmed publisher
    ..Taken together, our results show that bone marrow-derived MSCs can contribute to the gastric epithelium. The K19-positive MSC fraction that is induced by chronic H. felis infection appears to be the important subset in this process...
  48. Schmitz J, McCracken V, Dimmitt R, Lorenz R. Expression of CXCL15 (Lungkine) in murine gastrointestinal, urogenital, and endocrine organs. J Histochem Cytochem. 2007;55:515-24 pubmed
    ..increased expression of CXCL15 during pulmonary inflammation, gastric inflammation induced by infection with Helicobacter felis caused an increase in gastric CXCL15 expression...
  49. Tran C, Huynh H, van den Berg M, van der Pas M, Campbell M, Philcox J, et al. Helicobacter-induced gastritis in mice not expressing metallothionein-I and II. Helicobacter. 2003;8:533-41 pubmed
    ..This study investigates the role of MT in H. pylori-induced gastritis in mice...
  50. Secko D. Do stem cells cause gastric cancer?. CMAJ. 2005;172:325-6 pubmed
  51. McCracken V, Martin S, Lorenz R. The Helicobacter felis model of adoptive transfer gastritis. Immunol Res. 2005;33:183-94 pubmed
    ..Although the critical components of this gastric infiltrate that lead to disease are unclear, the Helicobacter felis-infected mouse and other mouse models of Helicobacter-associated gastritis have demonstrated the critical ..
  52. Stoicov C, Cai X, Li H, Klucevsek K, Carlson J, Saffari R, et al. Major histocompatibility complex class II inhibits fas antigen-mediated gastric mucosal cell apoptosis through actin-dependent inhibition of receptor aggregation. Infect Immun. 2005;73:6311-21 pubmed
    ..For these studies we used the well-described C57BL/6 mouse model of Helicobacter pylori and Helicobacter felis infection...
  53. Asfaha S, Dubeykovskiy A, Tomita H, Yang X, Stokes S, Shibata W, et al. Mice that express human interleukin-8 have increased mobilization of immature myeloid cells, which exacerbates inflammation and accelerates colon carcinogenesis. Gastroenterology. 2013;144:155-66 pubmed publisher
    ..We generated mice that carry a bacterial artificial chromosome that encompasses the entire human IL-8 gene, including its regulatory elements (IL-8Tg mice)...
  54. Mueller A, O Rourke J, Chu P, Kim C, Sutton P, Lee A, et al. Protective immunity against Helicobacter is characterized by a unique transcriptional signature. Proc Natl Acad Sci U S A. 2003;100:12289-94 pubmed
    Immunization with a whole-cell sonicate vaccine of Helicobacter felis in conjunction with cholera toxin as a mucosal adjuvant induces long-term protective immunity in a majority of laboratory mice...
  55. Nam K, Lee H, Sousa J, Weis V, O Neal R, Finke P, et al. Mature chief cells are cryptic progenitors for metaplasia in the stomach. Gastroenterology. 2010;139:2028-2037.e9 pubmed publisher
    ..Previous investigations have shown that infection of mice with Helicobacter felis or induction of acute parietal cell loss with the drug DMP-777 leads to the emergence of a type of ..
  56. Wang S, Asfaha S, Okumura T, Betz K, Muthupalani S, Rogers A, et al. Fibroblastic colony-forming unit bone marrow cells delay progression to gastric dysplasia in a helicobacter model of gastric tumorigenesis. Stem Cells. 2009;27:2301-11 pubmed publisher
    ..cells reduced the progression to low-grade gastric dysplasia in mice infected with chronic Helicobacter felis (p = .038)...
  57. Spinetti N, Zavala Spinetti L, Hempe J, Correa H, BEGUE R. Effect of long-term Helicobacter felis infection in a mouse model of streptozotocin-induced diabetes. Helicobacter. 2005;10:586-91 pubmed
    We previously REPORTED that mice with diabetes and short-term Helicobacter felis infection had an increase in glycated hemoglobin (HbA1c). Here we report the effect of long-term infection.
  58. Symonds E, Tran C, Butler R, Omari T. Gastric emptying is altered with the presence of gastritis. Dig Dis Sci. 2008;53:636-41 pubmed
    ..Changes to gastric emptying in mouse models of gastritis are associated with the presence of nutrients. Altered gastric emptying may contribute to symptoms commonly reported in humans with gastritis...
  59. BEGUE R, Manning J, Correa H. Real-time PCR for quantification of Helicobacter felis in mouse stomach. South Med J. 2006;99:1306-7 pubmed
  60. Tran C, Gøbel R, Symonds E. Metallothionein expression in Helicobacter-infected pregnant mice and their fetuses and pups. Dig Dis Sci. 2007;52:1527-32 pubmed
    ..H. felis infection altered MT levels of pregnant mice, their fetuses and pups, and mice postpartum, which may be a response to the marked inflammation...
  61. Lee J, Baxter T, Yamaguchi H, Wang T, Goldenring J, Anderson M. Differential protein analysis of spasomolytic polypeptide expressing metaplasia using laser capture microdissection and two-dimensional difference gel electrophoresis. Appl Immunohistochem Mol Morphol. 2003;11:188-93 pubmed
    ..antralization or pseudopyloric metaplasia) that develops in the atrophic fundus mucosa of mice infected with Helicobacter felis and in humans infected with Helicobacter pylori...
  62. Kang W, Rathinavelu S, Samuelson L, Merchant J. Interferon gamma induction of gastric mucous neck cell hypertrophy. Lab Invest. 2005;85:702-15 pubmed
    ..Ki67-labeled GSII-positive neck cells in Helicobacter felis-infected, but not G-/- stomachs, suggested that mucous neck cell proliferation accounted for expansion of ..
  63. Yang C, Gu L, Deng D. Bone marrow-derived cells may not be the original cells for carcinogen-induced mouse gastrointestinal carcinomas. PLoS ONE. 2013;8:e79615 pubmed publisher
    ..reported that bone marrow-derived cells (BMDC) can be original cells of mouse gastric cancers induced by Helicobacter felis (H. felis) infection...
  64. Kurt Jones E, Cao L, Sandor F, Rogers A, Whary M, Nambiar P, et al. Trefoil family factor 2 is expressed in murine gastric and immune cells and controls both gastrointestinal inflammation and systemic immune responses. Infect Immun. 2007;75:471-80 pubmed
    ..TFF2 knockout and wild-type mice were infected with Helicobacter felis (H. felis) to induce gastritis...
  65. Fukui T, Nishio A, Okazaki K, Kasahara K, Saga K, Tanaka J, et al. Cross-primed CD8+ cytotoxic T cells induce severe Helicobacter-associated gastritis in the absence of CD4+ T cells. Helicobacter. 2007;12:486-97 pubmed
    ..To study the roles of CD8(+) T cells, we examined the immune response in the gastric mucosa of Helicobacter felis-infected major histocompatibility complex (MHC) class II-deficient (II(-/-)) mice, which lack CD4(+) T cells.
  66. Bergin P, Raghavan S, Svensson H, Starckx S, Van Aelst I, Gjertsson I, et al. Gastric gelatinase B/matrix metalloproteinase-9 is rapidly increased in Helicobacter felis-induced gastritis. FEMS Immunol Med Microbiol. 2008;52:88-98 pubmed
    ..MMP-9 response resulting from Helicobacter infection in C57BL/6 and MMP-9 knock-out mice using the murine Helicobacter felis model were examined. H...
  67. Shiohara M, Kawakubo M, Matsumoto T, Kumagai T, Yamauchi K, Oana K, et al. Laboratory appraisal of optimal gaseous conditions for growth of zoonotic Helicobacter felis ATCC 49179. Microbiol Immunol. 2009;53:251-8 pubmed publisher
    An attempt was made to assess the hitherto undescribed optimal gaseous conditions for growth of zoonotic Helicobacter felis, focusing on the ratio of spiral-forms amongst the whole cells examined...
  68. Ericksen R, Rose S, Westphalen C, Shibata W, Muthupalani S, Tailor Y, et al. Obesity accelerates Helicobacter felis-induced gastric carcinogenesis by enhancing immature myeloid cell trafficking and TH17 response. Gut. 2014;63:385-94 pubmed publisher
    ..To investigate the role of obesity-associated inflammation and immune modulation in gastric carcinogenesis during Helicobacter-induced chronic gastric inflammation...
  69. Aristoteli L, O Rourke J, Danon S, Larsson H, Mellgard B, Mitchell H, et al. Urea, fluorofamide, and omeprazole treatments alter helicobacter colonization in the mouse gastric mucosa. Helicobacter. 2006;11:460-8 pubmed
    ..Its urease enzyme allows survival in acid conditions and drives bacterial intracellular metabolism. We aimed to investigate the role of urease in determining the intragastric distribution of Helicobacter species in vivo...
  70. Gonda T, Kim Y, Salas M, Gamble M, Shibata W, Muthupalani S, et al. Folic acid increases global DNA methylation and reduces inflammation to prevent Helicobacter-associated gastric cancer in mice. Gastroenterology. 2012;142:824-833.e7 pubmed publisher
    ..We examined the effects of FA supplementation on DNA methylation, gene expression, and gastric dysplasia in a transgenic mouse model that is etiologically and histologically well matched with human gastric cancers...
  71. Gossmann J, Stolte M, Lohoff M, Yu P, Moll R, Finkernagel F, et al. A Gain-Of-Function Mutation in the Plcg2 Gene Protects Mice from Helicobacter felis-Induced Gastric MALT Lymphoma. PLoS ONE. 2016;11:e0150411 pubmed publisher
    ..Heterozygous BALB/c Plcg2Ali5/+ and wildtype (WT) mice were infected with Helicobacter felis (H. felis) and observed up to 16 months for development of gastric MALT lymphomas...
  72. Nomura S, Baxter T, Yamaguchi H, Leys C, Vartapetian A, Fox J, et al. Spasmolytic polypeptide expressing metaplasia to preneoplasia in H. felis-infected mice. Gastroenterology. 2004;127:582-94 pubmed
    ..To examine the relationship of SPEM to the neoplastic process in the H. felis -infected C57BL/6 mouse, we have now studied the association of SPEM-related transcripts with preneoplasia...
  73. Sutton P, O Rourke J, Wilson J, Dixon M, Lee A. Immunisation against Helicobacter felis infection protects against the development of gastric MALT Lymphoma. Vaccine. 2004;22:2541-6 pubmed
    ..The formation of mucosa-associated lymphoid tissue (MALT) in response to Helicobacter pylori infection is closely associated with the development of primary gastric MALT lymphoma...
  74. Gasbarrini A, Carloni E, Gasbarrini G, Menard A. Helicobacter pylori and extragastric diseases -- other helicobacters. Helicobacter. 2003;8 Suppl 1:68-76 pubmed
    ..New Helicobacter species are regularly described and molecular methods are developed to improve their detection. Helicobacter felis remains the major species to be used in animal models of Helicobacter infection.
  75. Khamri W, Worku M, Anderson A, Walker M, Hawgood S, Reid K, et al. Helicobacter infection in the surfactant protein D-deficient mouse. Helicobacter. 2007;12:112-23 pubmed
    ..SP-D binds to Helicobacter in vitro, suggesting the involvement of SP-D in Helicobacter-induced immune responses. The aim of this study was to determine the role of SP-D in gastric epithelial defense in vivo...
  76. Okumura T, Ericksen R, Takaishi S, Wang S, Dubeykovskiy Z, Shibata W, et al. K-ras mutation targeted to gastric tissue progenitor cells results in chronic inflammation, an altered microenvironment, and progression to intraepithelial neoplasia. Cancer Res. 2010;70:8435-45 pubmed publisher
    ..K19-K-ras-V12 (K19-kras) transgenic mice were assessed at 3, 6, 12, and 18 months of age, in comparison with Helicobacter felis-infected wild-type littermates...
  77. Tomita H, Takaishi S, Menheniott T, Yang X, Shibata W, Jin G, et al. Inhibition of gastric carcinogenesis by the hormone gastrin is mediated by suppression of TFF1 epigenetic silencing. Gastroenterology. 2011;140:879-91 pubmed publisher
    ..Although hormones have been associated with cancer risk, the mechanisms have not been determined. The peptide hormone gastrin exerts a suppressive effect on antral gastric carcinogenesis...