vibrio vulnificus

Summary

Summary: A species of halophilic bacteria in the genus VIBRIO, which lives in warm SEAWATER. It can cause infections in those who eat raw contaminated seafood or have open wounds exposed to seawater.

Top Publications

  1. Vickery M, Nilsson W, Strom M, Nordstrom J, DePaola A. A real-time PCR assay for the rapid determination of 16S rRNA genotype in Vibrio vulnificus. J Microbiol Methods. 2007;68:376-84 pubmed
    ..we recently reported a significant association between the type B 16S rRNA gene and clinical strains of Vibrio vulnificus associated with the consumption of raw oysters...
  2. Aagesen A, HASE C. Sequence analyses of type IV pili from Vibrio cholerae, Vibrio parahaemolyticus, and Vibrio vulnificus. Microb Ecol. 2012;64:509-24 pubmed publisher
    ..cholerae. Although the mechanism underlying this intriguing diversity has yet to be elucidated, our analyses are an important first step towards gaining insights into the various aspects of Vibrio ecology. ..
  3. Hsieh J, Pan C, Chen J. Tilapia hepcidin (TH)2-3 as a transgene in transgenic fish enhances resistance to Vibrio vulnificus infection and causes variations in immune-related genes after infection by different bacterial species. Fish Shellfish Immunol. 2010;29:430-9 pubmed publisher
    ..In vivo, transgenic TH2-3 fish (of the F3 generation) were challenged with Vibrio vulnificus (204) and Streptococcus agalactiae (SA). Results showed significant clearance of bacterial numbers of V...
  4. Chung K, Cho E, Kim M, Kim Y, Kim S, Yang H, et al. RtxA1-induced expression of the small GTPase Rac2 plays a key role in the pathogenicity of Vibrio vulnificus. J Infect Dis. 2010;201:97-105 pubmed publisher
    Infection with the human pathogen Vibrio vulnificus leads to the generation of reactive oxygen species (ROS) via NAD(P)H oxidase (Nox) in host cells. In the present study, we employed mutant V...
  5. Kim Y, Lee S, Kim B, Choy H, Rhee J. A dual regulatory role of cyclic adenosine monophosphate receptor protein in various virulence traits of Vibrio vulnificus. Microbiol Immunol. 2013;57:273-80 pubmed publisher
    b>Vibrio vulnificus causes fatal septicemia in susceptible subjects after the ingestion of raw seafood. In the present study, the roles of cyclic adenosine monophosphate (cAMP) receptor protein (CRP) in V...
  6. Park J, Cho Y, Chun J, Seok Y, Lee J, Kim K, et al. Complete genome sequence of Vibrio vulnificus MO6-24/O. J Bacteriol. 2011;193:2062-3 pubmed publisher
    b>Vibrio vulnificus is the causative agent of life-threatening septicemia and severe wound infections. Here, we announce the complete annotated genome sequence of V. vulnificus MO6-24/O, isolated from a patient with septicemia...
  7. Yu H, Lee Y, Park K, Rah S, Noh E, Song E, et al. Membrane cholesterol is required for activity of Vibrio vulnificus cytolysin. Arch Microbiol. 2007;187:467-73 pubmed
    b>Vibrio vulnificus cytolysin (VVC) forms a pore in the plasma membrane and induces cytolysis of various cells including erythrocytes, neutrophil and endothelial cells...
  8. Lee D, Jeong H, Jeong H, Kim K, Kim H, Choi S. A consensus sequence for binding of SmcR, a Vibrio vulnificus LuxR homologue, and genome-wide identification of the SmcR regulon. J Biol Chem. 2008;283:23610-8 pubmed publisher
    ..In the present study, DNA targets of SmcR, a Vibrio vulnificus LuxR homologue, were selected from a random pool of DNA fragments by using a cycle selection procedure ..
  9. Bisharat N, Cohen D, Maiden M, Crook D, Peto T, Harding R. The evolution of genetic structure in the marine pathogen, Vibrio vulnificus. Infect Genet Evol. 2007;7:685-93 pubmed
    Multi-locus sequence types (MLST) from a global collection of Vibrio vulnificus isolates were analysed for the contribution of recombination to the evolution of two divergent clusters of strains and a human-pathogenic hybrid genotype, ..

More Information

Publications99

  1. Jeong H, Satchell K. Additive function of Vibrio vulnificus MARTX(Vv) and VvhA cytolysins promotes rapid growth and epithelial tissue necrosis during intestinal infection. PLoS Pathog. 2012;8:e1002581 pubmed publisher
    b>Vibrio vulnificus is a pathogen that causes both severe necrotizing wound infections and life-threatening food-borne infections...
  2. Gulig P, Tucker M, Thiaville P, Joseph J, Brown R. USER friendly cloning coupled with chitin-based natural transformation enables rapid mutagenesis of Vibrio vulnificus. Appl Environ Microbiol. 2009;75:4936-49 pubmed publisher
    b>Vibrio vulnificus is a bacterial contaminant of shellfish and causes highly lethal sepsis and destructive wound infections...
  3. Sanjuan E, Fouz B, Oliver J, Amaro C. Evaluation of genotypic and phenotypic methods to distinguish clinical from environmental Vibrio vulnificus strains. Appl Environ Microbiol. 2009;75:1604-13 pubmed publisher
    b>Vibrio vulnificus is a heterogeneous bacterial species that comprises virulent and avirulent strains from environmental and clinical sources that have been grouped into three biotypes...
  4. Koo B, Lee J, Kim S, Yoon H, Kim K, Kwon K, et al. Phospholipase A as a potent virulence factor of Vibrio vulnificus. Int J Mol Med. 2007;20:913-8 pubmed
    b>Vibrio vulnificus infection has attracted special interest because of its high mortality rate. However, the identification of its major pathogenic determinant still remains obscure. In this study, a cytolysin-negative mutant strain of V...
  5. Ziolo K, Jeong H, Kwak J, Yang S, Lavker R, Satchell K. Vibrio vulnificus biotype 3 multifunctional autoprocessing RTX toxin is an adenylate cyclase toxin essential for virulence in mice. Infect Immun. 2014;82:2148-57 pubmed publisher
    b>Vibrio vulnificus is an environmental organism that causes both food-borne and wound infections with high morbidity and mortality in humans...
  6. Gulig P, De Crecy Lagard V, Wright A, Walts B, Telonis Scott M, McIntyre L. SOLiD sequencing of four Vibrio vulnificus genomes enables comparative genomic analysis and identification of candidate clade-specific virulence genes. BMC Genomics. 2010;11:512 pubmed publisher
    b>Vibrio vulnificus is the leading cause of reported death from consumption of seafood in the United States...
  7. Huff K, Aroonnual A, Littlejohn A, Rajwa B, Bae E, Banada P, et al. Light-scattering sensor for real-time identification of Vibrio parahaemolyticus, Vibrio vulnificus and Vibrio cholerae colonies on solid agar plate. Microb Biotechnol. 2012;5:607-20 pubmed publisher
    The three most common pathogenic species of Vibrio, Vibrio cholerae, Vibrio parahaemolyticus and Vibrio vulnificus, are of major concerns due to increased incidence of water- and seafood-related outbreaks and illness worldwide...
  8. Starks A, Bourdage K, Thiaville P, Gulig P. Use of a marker plasmid to examine differential rates of growth and death between clinical and environmental strains of Vibrio vulnificus in experimentally infected mice. Mol Microbiol. 2006;61:310-23 pubmed
    b>Vibrio vulnificus is Gram-negative bacterium that contaminates oysters, causing highly lethal sepsis after consumption of raw oysters and wound infection. We previously described two sets of V...
  9. Kuo C, Dai Z, Wu J, Hsieh T, Hung C, Hsu J. Septic arthritis as the initial manifestation of fatal Vibrio vulnificus septicemia in a patient with thalassemia and iron overload. Pediatr Blood Cancer. 2009;53:1156-8 pubmed publisher
    b>Vibrio vulnificus infection is an uncommon but potentially fatal disease in children such that prompt recognition has prognostic implications...
  10. Shao C, Lo H, Lin J, Hor L. Regulation of cytotoxicity by quorum-sensing signaling in Vibrio vulnificus is mediated by SmcR, a repressor of hlyU. J Bacteriol. 2011;193:2557-65 pubmed publisher
    Cytotoxicity is an important virulence determinant in the pathogenesis of Vibrio vulnificus, and two cytotoxins, RTX (encoded by rtxA1) and cytolysin/hemolysin (encoded by vvhA), have been identified in this organism...
  11. Izumiya H, Matsumoto K, Yahiro S, Lee J, Morita M, Yamamoto S, et al. Multiplex PCR assay for identification of three major pathogenic Vibrio spp., Vibrio cholerae, Vibrio parahaemolyticus, and Vibrio vulnificus. Mol Cell Probes. 2011;25:174-6 pubmed publisher
    ..molecular identification of 3 major pathogenic Vibrio species: Vibrio cholerae, Vibrio parahaemolyticus, and Vibrio vulnificus. It specifically identified them from among 133 strains of various Vibrio species and other genera, and was ..
  12. DePaola A, Jones J, Woods J, Burkhardt W, Calci K, Krantz J, et al. Bacterial and viral pathogens in live oysters: 2007 United States market survey. Appl Environ Microbiol. 2010;76:2754-68 pubmed publisher
    ..S. shellfish sanitation system to those in other countries. ..
  13. Lam A, Pardon E, Korotkov K, Hol W, Steyaert J. Nanobody-aided structure determination of the EpsI:EpsJ pseudopilin heterodimer from Vibrio vulnificus. J Struct Biol. 2009;166:8-15 pubmed publisher
    ..The crystallization of the EpsI:EpsJ pseudopilin heterodimer from Vibrio vulnificus was greatly accelerated by the use of nanobodies, which are the smallest antigen-binding fragments derived ..
  14. Chen Y, Liu X, Yan J, Li X, Mei L, Mao Q, et al. Foodborne pathogens in retail oysters in south China. Biomed Environ Sci. 2010;23:32-6 pubmed
    ..in different seasons from South China and analyzed for the prevalence and levels of Listeria monocytogenes, Vibrio vulnificus and Vibrio parahaemolyticus. None of L...
  15. Mouzopoulos G, Stamatakos M, Tzurbakis M, Batanis G, Michou E, Mouzopoulos D, et al. Lower extremity infections by vibrio vulnificus. Chirurgia (Bucur). 2008;103:201-3 pubmed
    b>Vibrio vulnificus is a Gram-negative pathogen which is found in seawater and shellfish during warm months and can cause local infections in healthy individuals or septicemia in patients with chronic liver disease...
  16. Nishi K, Lee H, Park S, Bae S, Lee S, Adams P, et al. Crystal structure of the transcriptional activator HlyU from Vibrio vulnificus CMCP6. FEBS Lett. 2010;584:1097-102 pubmed publisher
    HlyU is a transcription factor of the ArsR/SmtB family and activates the expression of the pathogenic Vibrio vulnificus RTX toxin. In contrast to the other metal-responding ArsR/SmtB proteins, HlyU does not sense metal ions...
  17. Roh J, Lee M, Lee H, Kim S, Cho Y, Kim Y, et al. Transcriptional regulatory cascade for elastase production in Vibrio vulnificus: LuxO activates luxT expression and LuxT represses smcR expression. J Biol Chem. 2006;281:34775-84 pubmed publisher
    b>Vibrio vulnificus causes diseases through actions of various virulence factors, including the elastase encoded by the vvpE gene. Through transposon mutagenesis of V. vulnificus, vvpE expression was shown to be increased by luxO mutation...
  18. Baker Austin C, McArthur J, Lindell A, Wright M, Tuckfield R, Gooch J, et al. Multi-site analysis reveals widespread antibiotic resistance in the marine pathogen Vibrio vulnificus. Microb Ecol. 2009;57:151-9 pubmed publisher
    b>Vibrio vulnificus is a serious opportunistic human pathogen commonly found in subtropical coastal waters, and is the leading cause of seafood-borne mortality in the USA...
  19. Liu M, Alice A, Naka H, Crosa J. The HlyU protein is a positive regulator of rtxA1, a gene responsible for cytotoxicity and virulence in the human pathogen Vibrio vulnificus. Infect Immun. 2007;75:3282-9 pubmed
    b>Vibrio vulnificus is an opportunistic human pathogen that preferentially infects compromised iron-overloaded patients, causing a fatal primary septicemia with very rapid progress, resulting in a high mortality rate...
  20. Blackwell K, Oliver J. The ecology of Vibrio vulnificus, Vibrio cholerae, and Vibrio parahaemolyticus in North Carolina estuaries. J Microbiol. 2008;46:146-53 pubmed publisher
    ..here we have simultaneously examined several estuarine sites for Vibrio vulnificus, V. cholerae, and V. parahaemolyticus...
  21. Weis K, Hammond R, Hutchinson R, Blackmore C. Vibrio illness in Florida, 1998-2007. Epidemiol Infect. 2011;139:591-8 pubmed publisher
    ..Common Vibrio species reported were Vibrio vulnificus (33%), V. parahaemolyticus (29%), and V. alginolyticus (16%)...
  22. Chiang S, Tang H, Chang P, Cheng K, Ko W, Chen C, et al. Synergistic antimicrobial effect of cefotaxime and minocycline on proinflammatory cytokine levels in a murine model of Vibrio vulnificus infection. J Microbiol Immunol Infect. 2007;40:123-33 pubmed
    b>Vibrio vulnificus causes primary bacteremia and necrotizing wound infection, leading to high morbidity and mortality in humans...
  23. Tajiri T, Tate G, Akita H, Ohike N, Masunaga A, Kunimura T, et al. Autopsy cases of fulminant-type bacterial infection with necrotizing fasciitis: group A (beta) hemolytic Streptococcus pyogenes versus Vibrio vulnificus infection. Pathol Int. 2008;58:196-202 pubmed publisher
    ..was a woman with group A (beta) hemolytic Streptococcus pyogenes infection, and the latter was a man with Vibrio vulnificus infection...
  24. Liu M, Rose M, Crosa J. Homodimerization and binding of specific domains to the target DNA are essential requirements for HlyU to regulate expression of the virulence gene rtxA1, encoding the repeat-in-toxin protein in the human pathogen Vibrio vulnificus. J Bacteriol. 2011;193:6895-901 pubmed publisher
    ..The virulence gene rtxA1, encoding the repeat-in-toxin protein, plays an essential role in the pathogenesis of Vibrio vulnificus infections...
  25. Nakhamchik A, Wilde C, Rowe Magnus D. Cyclic-di-GMP regulates extracellular polysaccharide production, biofilm formation, and rugose colony development by Vibrio vulnificus. Appl Environ Microbiol. 2008;74:4199-209 pubmed publisher
    b>Vibrio vulnificus is a human and animal pathogen that carries the highest death rate of any food-borne disease agent. It colonizes shellfish and forms biofilms on the surfaces of plankton, algae, fish, and eels...
  26. Mahmud Z, Neogi S, Kassu A, Mai Huong B, Jahid I, Islam M, et al. Occurrence, seasonality and genetic diversity of Vibrio vulnificus in coastal seaweeds and water along the Kii Channel, Japan. FEMS Microbiol Ecol. 2008;64:209-18 pubmed publisher
    b>Vibrio vulnificus is a ubiquitous toxigenic bacterium found in a coastal environment but little is known about its occurrence and seasonality among seaweeds, which are widely consumed as seafood in Japan...
  27. Lee Y, Chuang Y. Ibuprofen augments pro-inflammatory cytokine release in a mouse model of Vibrio vulnificus infection. Microbiol Immunol. 2010;54:542-50 pubmed publisher
    ..the effects of ibuprofen on cytokine production and mortality in a mouse model of septic shock induced by Vibrio vulnificus, strain Chi Mei Vv05191...
  28. Liu M, Crosa J. The regulator HlyU, the repeat-in-toxin gene rtxA1, and their roles in the pathogenesis of Vibrio vulnificus infections. Microbiologyopen. 2012;1:502-13 pubmed publisher
    HlyU is a master regulator that plays an essential role in the virulence of the human pathogen Vibrio vulnificus. One of the most noteworthy characteristics of HlyU regulation in this organism is its positive control of the expression of ..
  29. Jeong H, Oh M, Kim B, Lee M, Han H, Choi S. The capability of catabolic utilization of N-acetylneuraminic acid, a sialic acid, is essential for Vibrio vulnificus pathogenesis. Infect Immun. 2009;77:3209-17 pubmed publisher
    ..In order to analyze the role of Neu5Ac catabolism in Vibrio vulnificus pathogenesis, a mutant with disruption of the nanA gene encoding Neu5Ac lyase was constructed by allelic ..
  30. Park K, Kim J, Lee Y, Moon Y, Hur H, Choi Y, et al. Low-density lipoprotein protects Vibrio vulnificus-induced lethality through blocking lipopolysaccharide action. Exp Mol Med. 2007;39:673-8 pubmed
    ..We have previously demonstrated that LDL directly inactivates the hemolytic activity of Vibrio vulnificus cytolysin (VVC) in vitro...
  31. Na H, Cha M, Oh D, Cho C, Rhee J, Kim Y. Protective mechanism of curcumin against Vibrio vulnificus infection. FEMS Immunol Med Microbiol. 2011;63:355-62 pubmed publisher
    ..This study examined the effect of curcumin on a Vibrio vulnificus infection. The cytotoxicity of V...
  32. Kim D, Jung S, Jang H, Lee C, Lee S, Yun N, et al. Vibrio vulnificus DNA load and mortality. J Clin Microbiol. 2011;49:413-5 pubmed publisher
    We determined the association between DNA load and mortality in patients with Vibrio vulnificus infection...
  33. Sugiyama H, Kashimoto T, Ueno S, Ehara H, Kodama T, Iida T, et al. Relationship between localization on cellular membranes and cytotoxicity of Vibrio vulnificus hemolysin. PLoS ONE. 2011;6:e26018 pubmed publisher
    b>Vibrio vulnificus secretes a hemolysin/cytolysin (VVH) that induces cytolysis in target cells...
  34. Jones J, Hara Kudo Y, Krantz J, Benner R, Smith A, Dambaugh T, et al. Comparison of molecular detection methods for Vibrio parahaemolyticus and Vibrio vulnificus. Food Microbiol. 2012;30:105-11 pubmed publisher
    ..study compares several molecular methods for detection of total and pathogenic Vibrio parahaemolyticus and Vibrio vulnificus, in MPN enrichments from oysters and fish intestine samples...
  35. Tsai Y, Huang T, Hsu R, Weng Y, Hsu W, Huang K, et al. Necrotizing soft-tissue infections and primary sepsis caused by Vibrio vulnificus and Vibrio cholerae non-O1. J Trauma. 2009;66:899-905 pubmed publisher
    ..This study examined fulminating clinical characteristics of Vibrio vulnificus and Vibrio cholerae non-O1 soft-tissue infections and identified outcome predictors.
  36. Han F, Walker R, Janes M, Prinyawiwatkul W, Ge B. Antimicrobial susceptibilities of Vibrio parahaemolyticus and Vibrio vulnificus isolates from Louisiana Gulf and retail raw oysters. Appl Environ Microbiol. 2007;73:7096-8 pubmed
    The antimicrobial susceptibilities of 168 Vibrio parahaemolyticus and 151 Vibrio vulnificus isolates recovered from 82 Louisiana Gulf and retail oysters in 2005 and 2006 were determined...
  37. Kim Y, Kim B, Park Y, Choi W, Hwang J, Kang B, et al. Crystal structure of SmcR, a quorum-sensing master regulator of Vibrio vulnificus, provides insight into its regulation of transcription. J Biol Chem. 2010;285:14020-30 pubmed publisher
    ..SmcR, a homologue of Vibrio harveyi LuxR, has been proposed as a quorum-sensing master regulator of Vibrio vulnificus, an opportunistic human pathogen...
  38. Yanez M, Korotkov K, Abendroth J, Hol W. The crystal structure of a binary complex of two pseudopilins: EpsI and EpsJ from the type 2 secretion system of Vibrio vulnificus. J Mol Biol. 2008;375:471-86 pubmed publisher
    ..Moreover, the 2.3 A resolution crystal structure of a complex of EspI and EpsJ from Vibrio vulnificus represents the first atomic resolution structure of a complex of two different pseudopilin components from ..
  39. Kim D, Cho H, Kang J, Kim H, Park C. Deferasirox plus ciprofloxacin combination therapy after rapid diagnosis of Vibrio vulnificus sepsis using real-time polymerase chain reaction. J Infect. 2008;57:489-92 pubmed publisher
    We report a case of Vibrio vulnificus sepsis developed during deferoxamine therapy for transfusional iron overload due to secondary hemochromatosis of myelodysplastic syndrome...
  40. Kim S, Park J, Lee H, Kim W, Ryu J, Han H, et al. LuxR homologue SmcR is essential for Vibrio vulnificus pathogenesis and biofilm detachment, and its expression is induced by host cells. Infect Immun. 2013;81:3721-30 pubmed publisher
    ..In the present study, the functions of quorum sensing in the pathogenesis of Vibrio vulnificus, a food-borne pathogen, were assessed by evaluating the virulence of a mutant deficient in SmcR, a quorum-..
  41. Broza Y, Danin Poleg Y, Lerner L, Broza M, Kashi Y. Vibrio vulnificus typing based on simple sequence repeats: insights into the biotype 3 group. J Clin Microbiol. 2007;45:2951-9 pubmed
    b>Vibrio vulnificus is an opportunistic, highly invasive human pathogen with worldwide distribution. V. vulnificus strains are commonly divided into three biochemical groups (biotypes), most members of which are pathogenic...
  42. Pan C, Lee S, Rajanbabu V, Lin C, Chen J. Insights into the antibacterial and immunomodulatory functions of tilapia hepcidin (TH)2-3 against Vibrio vulnificus infection in mice. Dev Comp Immunol. 2012;36:166-73 pubmed publisher
    ..investigated the antibacterial and immunomodulatory functions of TH2-3 in mice infected with the pathogen, Vibrio vulnificus. A TH2-3 injection in V...
  43. Goo S, Han Y, Kim W, Lee K, Park S. Vibrio vulnificus IlpA-induced cytokine production is mediated by Toll-like receptor 2. J Biol Chem. 2007;282:27647-58 pubmed
    b>Vibrio vulnificus is a pathogenic bacterium causing primary septicemia, which follows a classical septic shock pathway, including an overwhelming inflammatory cytokine response. In this study, we identified a putative lipoprotein of V...
  44. Oh M, Lee S, Lee D, Choi S. Regulation of the Vibrio vulnificus hupA gene by temperature alteration and cyclic AMP receptor protein and evaluation of its role in virulence. Infect Immun. 2009;77:1208-15 pubmed publisher
    ..In this study, cellular levels of Vibrio vulnificus HupA, a heme receptor protein, and the hupA transcript were found to increase in cells grown at 40 degrees C ..
  45. Richards G, Fay J, Dickens K, Parent M, Soroka D, Boyd E. Predatory bacteria as natural modulators of Vibrio parahaemolyticus and Vibrio vulnificus in seawater and oysters. Appl Environ Microbiol. 2012;78:7455-66 pubmed
    ..The growth and persistence of Vibrio parahaemolyticus and Vibrio vulnificus were assessed in natural seawater and in the Eastern oyster, Crassostrea virginica...
  46. Lee H, Kim J, Lee M, Park S, Lee K. Regulation of haemolysin (VvhA) production by ferric uptake regulator (Fur) in Vibrio vulnificus: repression of vvhA transcription by Fur and proteolysis of VvhA by Fur-repressive exoproteases. Mol Microbiol. 2013;88:813-26 pubmed publisher
    VvhA produced by Vibrio vulnificus exhibits cytolytic activity to human cells including erythrocytes...
  47. Bogard R, Oliver J. Role of iron in human serum resistance of the clinical and environmental Vibrio vulnificus genotypes. Appl Environ Microbiol. 2007;73:7501-5 pubmed
    ..Here we report that the clinical genotype of Vibrio vulnificus is significantly better able to survive in human serum than is the environmental genotype...
  48. Inoue Y, Miyasaka J, Ono T, Ihn H. The growth of Vibrio vulnificus and the habitat of infected patients in Kumamoto. Biosci Trends. 2007;1:134-9 pubmed
    In Japan, Vibrio vulnificus (V. vulnificus) infection is very rare, and most infections have occurred in Kumamoto Prefecture (1), and especially around the Ariake and Yatsushiro seas...
  49. Wang J, Sasaki T, Maehara Y, Nakao H, Tsuchiya T, Miyoshi S. Variation of extracellular proteases produced by Vibrio vulnificus clinical isolates: genetic diversity of the metalloprotease gene (vvp), and serine protease secretion by vvp-negative strains. Microb Pathog. 2008;44:494-500 pubmed publisher
    b>Vibrio vulnificus is a causative agent of septicemia or wound infection in human and eel; however, the genetic variation between human and eel isolates has been reported...
  50. Kim H, Kim S, Jeong H, Kim T, Kim J, Choy H, et al. Integrative genome-scale metabolic analysis of Vibrio vulnificus for drug targeting and discovery. Mol Syst Biol. 2011;7:460 pubmed publisher
    ..genomic information for drug targeting and discovery, and apply this approach to the opportunistic pathogen Vibrio vulnificus CMCP6. First, we partially re-sequenced and fully re-annotated the V...
  51. Roig F, Gonz lez Candelas F, Amaro C. Domain organization and evolution of multifunctional autoprocessing repeats-in-toxin (MARTX) toxin in Vibrio vulnificus. Appl Environ Microbiol. 2011;77:657-68 pubmed publisher
    ..multifunctional autoprocessing repeats-in-toxin (MARTX) toxin domain organization within the aquatic species Vibrio vulnificus as well as to study the evolution of the rtxA1 gene...
  52. Chhabra P, Huang Y, Frank J, Chmielewski R, Gates K. Fate of Staphylococcus aureus, Salmonella enterica serovar typhimurium, and vibrio vulnificus in raw oysters treated with chitosan. J Food Prot. 2006;69:1600-4 pubmed
    The fate of Staphylococcus aureus, Salmonella enterica serovar Typhimurium, and Vibrio vulnificus in oysters treated with chitosan was investigated. Three concentrations (0.5, 1.0, and 2.0%) of chitosan in 0...
  53. Lee H, Bang S, Lee K, Park S. Positive regulation of fur gene expression via direct interaction of fur in a pathogenic bacterium, Vibrio vulnificus. J Bacteriol. 2007;189:2629-36 pubmed
    ..In Vibrio vulnificus, a human pathogen causing gastroenteritis and septicemia, fur gene expression is positively regulated by Fur ..
  54. Kim J, Choi S, Lee J. Lysine decarboxylase expression by Vibrio vulnificus is induced by SoxR in response to superoxide stress. J Bacteriol. 2006;188:8586-92 pubmed
    Lysine decarboxylase expression by Vibrio vulnificus, which is up-regulated by CadC in response to acid stress, is also induced by SoxR in response to superoxide stress...
  55. Warner E, Oliver J. Refined medium for direct isolation of Vibrio vulnificus from oyster tissue and seawater. Appl Environ Microbiol. 2007;73:3098-100 pubmed
    We have developed a new medium for the direct isolation of Vibrio vulnificus from water and oyster samples. The medium was shown in laboratory and field studies to be highly selective without providing preferential isolation of either V...
  56. Chung P, Chuang S, Tsang T, Wai man L, Yung R, Lo J. Cutaneous injury and Vibrio vulnificus infection. Emerg Infect Dis. 2006;12:1302-3 pubmed
  57. Lim J, Choi S. IscR is a global regulator essential for pathogenesis of Vibrio vulnificus and induced by host cells. Infect Immun. 2014;82:569-78 pubmed publisher
    ..human intestinal epithelial cells than the wild type was screened from a random transposon mutant library of Vibrio vulnificus, and an open reading frame encoding an Fe-S cluster regulator, IscR, was identified using a transposon-..
  58. Bisharat N, Amaro C, Fouz B, Llorens A, Cohen D. Serological and molecular characteristics of Vibrio vulnificus biotype 3: evidence for high clonality. Microbiology. 2007;153:847-56 pubmed
    b>Vibrio vulnificus biotype 3 has been implicated as the causative pathogen of an ongoing disease outbreak that erupted in Israel in 1996. Recent work based on multi-locus sequence typing (MLST) showed that V...
  59. Shin N, Lee D, Yoo H. Analysis of gene expression in mouse alveolar macrophages stimulated with quorum-sensing mutants of Vibrio vulnificus. Jpn J Infect Dis. 2008;61:402-6 pubmed
    ..In this study, microarray technology was used to identify the genes that are affected by the Vibrio vulnificus quorum-sensing genes, luxS and smcR...
  60. Jones M, Oliver J. Vibrio vulnificus: disease and pathogenesis. Infect Immun. 2009;77:1723-33 pubmed publisher
  61. Yokochi N, Tanaka S, Matsumoto K, Oishi H, Tashiro Y, Yoshikane Y, et al. Distribution of virulence markers among Vibrio vulnificus isolates of clinical and environmental origin and regional characteristics in Japan. PLoS ONE. 2013;8:e55219 pubmed publisher
    b>Vibrio vulnificus is an opportunistic human pathogen that is widely distributed in estuarine environments and is capable of causing necrotizing fasciitis and sepsis. In Japan, based on epidemiological research, the incidences of V...
  62. Miyoshi S, Wang J, Katoh K, Senoh M, Mizuno T, Maehara Y. An extracellular serine protease produced by Vibrio vulnificus NCIMB 2137, a metalloprotease-gene negative strain isolated from a diseased eel. World J Microbiol Biotechnol. 2012;28:1633-9 pubmed publisher
    b>Vibrio vulnificus is a ubiquitous estuarine microorganism but causes fatal systemic infections in immunocompromised humans, cultured eels or shrimps...
  63. Lee H, Choi S, Choi S. Complete genome sequence of Vibrio vulnificus bacteriophage SSP002. J Virol. 2012;86:7711 pubmed publisher
    b>Vibrio vulnificus phages are abundant in coastal marine environments, shellfish, clams, and oysters. SSP002, a V. vulnificus-specific bacteriophage, was isolated from oysters from the west coast of South Korea...
  64. Kim J, Oh D, Cha M, Pyo B, Rhee J, Choy H, et al. Protective effect of polygoni cuspidati radix and emodin on Vibrio vulnificus cytotoxicity and infection. J Microbiol. 2008;46:737-43 pubmed publisher
    b>Vibrio vulnificus, a good model organism of bacterial septicemia, causes fatal septicemia manifesting a fulminating course and a high mortality rate within days. In order to identify new natural substances preventing V...
  65. Miyamoto K, Kosakai K, Ikebayashi S, Tsuchiya T, Yamamoto S, Tsujibo H. Proteomic analysis of Vibrio vulnificus M2799 grown under iron-repleted and iron-depleted conditions. Microb Pathog. 2009;46:171-7 pubmed publisher
    b>Vibrio vulnificus is an opportunistic marine bacterium that causes a serious, often fatal, infection in human. An important factor that determines the survival of V. vulnificus in the human body is the ability to acquire iron...
  66. Kim C, Chung Y, Shin S. Iron differentially regulates gene expression and extracellular secretion of Vibrio vulnificus cytolysin-hemolysin. J Infect Dis. 2009;200:582-9 pubmed publisher
    In a previous study, we showed that Vibrio vulnificus is a ferrophilic bacterium that requires high levels of available iron for growth...
  67. Grau B, Henk M, Garrison K, Olivier B, Schulz R, O Reilly K, et al. Further characterization of Vibrio vulnificus rugose variants and identification of a capsular and rugose exopolysaccharide gene cluster. Infect Immun. 2008;76:1485-97 pubmed publisher
    Capsular polysaccharide (CPS) is a major virulence factor in Vibrio vulnificus, and encapsulated strains have an opaque, smooth (OpS) colony morphology, while nonencapsulated strains have a translucent, smooth (TrS) colony morphology...
  68. Lin S, Fan T, Wu J, Hui C, Chen J. Immune response and inhibition of bacterial growth by electrotransfer of plasmid DNA containing the antimicrobial peptide, epinecidin-1, into zebrafish muscle. Fish Shellfish Immunol. 2009;26:451-8 pubmed
    ..These data demonstrate that electroporation of epinecidin-1 might have provoked an inflammatory response that accounts for the improvement in bacterial clearance...
  69. Lee B, Choi S, Kim T. Vibrio vulnificus RTX toxin plays an important role in the apoptotic death of human intestinal epithelial cells exposed to Vibrio vulnificus. Microbes Infect. 2008;10:1504-13 pubmed publisher
    During Vibrio vulnificus infection, V. vulnificus reaches the intestine and then invades the bloodstream by crossing the intestinal mucosal barrier of the host, which results in systemic septicemia...
  70. Kim W, Goo S, Shin M, Chun S, Lee H, Lee K, et al. Vibrio vulnificus-induced death of Jurkat T-cells requires activation of p38 mitogen-activated protein kinase by NADPH oxidase-derived reactive oxygen species. Cell Immunol. 2008;253:81-91 pubmed publisher
    b>Vibrio vulnificus, a pathogenic bacterium causing primary septicemia, exhibited cytotoxicity towards Jurkat cells of T-lymphocytes through intracellular reactive oxygen species (ROS) production...
  71. Broza Y, Raz N, Lerner L, Danin Poleg Y, Kashi Y. Genetic diversity of the human pathogen Vibrio vulnificus: a new phylogroup. Int J Food Microbiol. 2012;153:436-43 pubmed publisher
    The biotype 3 group of the human pathogen Vibrio vulnificus emerged in Israel probably as a result of genome hybridization of two bacterial populations. We performed a genomic and phylogenetic study of V...
  72. Bross M, Soch K, Morales R, Mitchell R. Vibrio vulnificus infection: diagnosis and treatment. Am Fam Physician. 2007;76:539-44 pubmed
    b>Vibrio vulnificus infection is the leading cause of death related to seafood consumption in the United States. This virulent, gram-negative bacterium causes two distinct syndromes...
  73. Kim Y, Kim B, Kim S, Kim C, Na H, Koh J, et al. Outer membrane vesicles of Vibrio vulnificus deliver cytolysin-hemolysin VvhA into epithelial cells to induce cytotoxicity. Biochem Biophys Res Commun. 2010;399:607-12 pubmed publisher
    The Gram-negative bacterium Vibrio vulnificus produces cytotoxins that induce the acute death of host cells. However, the secretory mechanisms of such cytotoxins have not been extensively studied...
  74. Sanjuan E, Gonzalez Candelas F, Amaro C. Polyphyletic origin of Vibrio vulnificus biotype 2 as revealed by sequence-based analysis. Appl Environ Microbiol. 2011;77:688-95 pubmed publisher
    A sequence-based analysis of seven housekeeping and virulence-related genes shows that the species Vibrio vulnificus is subdivided into three phylogenetic lineages that do not correspond with the biotypes and that biotype 2 is ..
  75. Lee C, Amaro C, Wu K, Valiente E, Chang Y, Tsai S, et al. A common virulence plasmid in biotype 2 Vibrio vulnificus and its dissemination aided by a conjugal plasmid. J Bacteriol. 2008;190:1638-48 pubmed
    Strains of Vibrio vulnificus, a marine bacterial species pathogenic for humans and eels, are divided into three biotypes, and those virulent for eels are classified as biotype 2...
  76. Matsumoto K, Ohshige K, Fujita N, Tomita Y, Mitsumizo S, Nakashima M, et al. Clinical features of Vibrio vulnificus infections in the coastal areas of the Ariake Sea, Japan. J Infect Chemother. 2010;16:272-9 pubmed publisher
    b>Vibrio vulnificus infection can result in necrotizing fasciitis and sepsis and is associated with high mortality. Most patients infected with this microbe have liver dysfunction as an underlying disease...
  77. Neupane G, Kim D, Yun N, Shin S, Lim S, Choi C. Quantitative PCR and in vivo efficacy of antibiotics in the treatment of Vibrio vulnificus infection in a mouse model. Eur J Clin Microbiol Infect Dis. 2012;31:2461-7 pubmed publisher
    ..intravenous doxycycline plus a third-generation cephalosporin or fluoroquinolone alone for the treatment of Vibrio vulnificus infections...
  78. Lee J, Kim D, Yun N, Neupane G, Jung S, Park K, et al. Tumor necrosis factor-? and mortality in patients infected with Vibrio vulnificus. Am J Trop Med Hyg. 2011;84:426-8 pubmed publisher
    Serum tumor necrosis factor-? (TNF-?) was evaluated in Vibrio vulnificus-infected patients at admission. The median TNF-? concentration in the non-survivor group was determined to be 261.0 pg/mL, in contrast to 69...
  79. Chen H, Athar R, Zheng G, Williams H. Prey bacteria shape the community structure of their predators. ISME J. 2011;5:1314-22 pubmed publisher
    ..Bacteriovorax, a predator within the group of BALOs, in environmental waters were fed two prey bacteria, Vibrio vulnificus and Vibrio parahaemolyticus...
  80. Kim H, Lee M, Chun S, Park S, Lee K. Role of NtrC in biofilm formation via controlling expression of the gene encoding an ADP-glycero-manno-heptose-6-epimerase in the pathogenic bacterium, Vibrio vulnificus. Mol Microbiol. 2007;63:559-74 pubmed
    To identify the genetic elements required for biofilm formation, we screened a pool of random Vibrio vulnificus mutants for their ability to form biofilms...
  81. Lee M, Kim H, Song S, Joo M, Lee S, Kim D, et al. The ?-barrel tip region of Escherichia coli TolC homologs of Vibrio vulnificus interacts with the MacA protein to form the functional macrolide-specific efflux pump MacAB-TolC. J Microbiol. 2013;51:154-9 pubmed publisher
    ..Two open reading frames in the Vibrio vulnificus genome that encode proteins homologous to Escherichia coli TolC, designated TolCV1 and TolCV2, have 51...
  82. Bauer A, Rørvik L. A novel multiplex PCR for the identification of Vibrio parahaemolyticus, Vibrio cholerae and Vibrio vulnificus. Lett Appl Microbiol. 2007;45:371-5 pubmed
    To establish a simple multiplex polymerase chain reaction (PCR) that will identify Vibrio parahaemolyticus, Vibrio cholerae and Vibrio vulnificus.
  83. Garrison Schilling K, Grau B, McCarter K, Olivier B, Comeaux N, Pettis G. Calcium promotes exopolysaccharide phase variation and biofilm formation of the resulting phase variants in the human pathogen Vibrio vulnificus. Environ Microbiol. 2011;13:643-54 pubmed publisher
    b>Vibrio vulnificus is a Gram-negative bacterium found in estuaries and coastal waters and is associated with human disease caused by ingestion of raw shellfish...
  84. Kim H, Kim D, Neupane G, Lee Y, Yang N, Jang S, et al. Comparison of conventional, nested, and real-time PCR assays for rapid and accurate detection of Vibrio vulnificus. J Clin Microbiol. 2008;46:2992-8 pubmed publisher
    ..Therefore, the appropriate application of the Q-PCR assay using blood is useful for the rapid diagnosis and subsequent treatment of V. vulnificus sepsis...
  85. Kim I, Kim B, Lee K, Kim I, Son J, Kim K. Identification of virulence factors in vibrio vulnificus by comparative transcriptomic analyses between clinical and environmental isolates using cDNA microarray. J Microbiol Biotechnol. 2011;21:1228-35 pubmed
    ..Mutants with lesions in the gene encoding pilin showed significantly higher LD50 values than that of wild type...
  86. Newton A, Kendall M, Vugia D, Henao O, Mahon B. Increasing rates of vibriosis in the United States, 1996-2010: review of surveillance data from 2 systems. Clin Infect Dis. 2012;54 Suppl 5:S391-5 pubmed publisher
    ..Epidemiologic patterns were similar in both systems. Current prevention efforts have failed to prevent increasing rates of vibriosis; more effective efforts will be needed to decrease rates. ..
  87. Liu M, Naka H, Crosa J. HlyU acts as an H-NS antirepressor in the regulation of the RTX toxin gene essential for the virulence of the human pathogen Vibrio vulnificus CMCP6. Mol Microbiol. 2009;72:491-505 pubmed publisher
    In Vibrio vulnificus, HlyU upregulates the expression of the large RTX toxin gene. In this work we identified the binding site of HlyU to -417 to -376 bp of the rtxA1 operon transcription start site...
  88. Senchenkova S, Shashkov A, Knirel Y, Esteve C, Alcaide E, Merino S, et al. Structure of a polysaccharide from the lipopolysaccharide of Vibrio vulnificus clinical isolate YJ016 containing 2-acetimidoylamino-2-deoxy-L-galacturonic acid. Carbohydr Res. 2009;344:1009-13 pubmed publisher
    A polysaccharide isolated after mild acid degradation of the lipopolysaccharide of Vibrio vulnificus clinical isolate YJ016 was found to contain L-Fuc, D-GlcpNAc, 2,4-diacetamido-2,4,6-trideoxy-D-glucose (di-N-acetylbacillosamine, D-..
  89. Guo Y, Rowe Magnus D. Overlapping and unique contributions of two conserved polysaccharide loci in governing distinct survival phenotypes in Vibrio vulnificus. Environ Microbiol. 2011;13:2888-990 pubmed publisher
    As an aetiological agent of bacterial sepsis and wound infections, Vibrio vulnificus is unique among the Vibrionacea...
  90. Collin B, Rehnstam Holm A. Occurrence and potential pathogenesis of Vibrio cholerae, Vibrio parahaemolyticus and Vibrio vulnificus on the South Coast of Sweden. FEMS Microbiol Ecol. 2011;78:306-13 pubmed publisher
    ..cholerae, Vibrio vulnificus and Vibrio parahaemolyticus in The Sound between Sweden and Denmark...