vibrio cholerae

Summary

Summary: The etiologic agent of CHOLERA.

Top Publications

  1. Borgeaud S, Blokesch M. Overexpression of the tcp gene cluster using the T7 RNA polymerase/promoter system and natural transformation-mediated genetic engineering of Vibrio cholerae. PLoS ONE. 2013;8:e53952 pubmed publisher
    The human pathogen and aquatic bacterium Vibrio cholerae belongs to the group of naturally competent bacteria...
  2. Pal R, Bag S, Dasgupta S, Das B, Bhadra R. Functional characterization of the stringent response regulatory gene dksA of Vibrio cholerae and its role in modulation of virulence phenotypes. J Bacteriol. 2012;194:5638-48 pubmed publisher
    ..govern cellular levels of ppGpp during various starvation stresses in the Gram-negative cholera pathogen Vibrio cholerae. Here we report functional characterization of the dksA gene of V...
  3. Dunstan R, Heinz E, Wijeyewickrema L, Pike R, Purcell A, Evans T, et al. Assembly of the type II secretion system such as found in Vibrio cholerae depends on the novel Pilotin AspS. PLoS Pathog. 2013;9:e1003117 pubmed publisher
    ..We have determined the crystal structure of the novel pilotin AspS from Vibrio cholerae, demonstrating convergent evolution wherein AspS is functionally equivalent and yet structurally unrelated to ..
  4. Dong T, Mekalanos J. Characterization of the RpoN regulon reveals differential regulation of T6SS and new flagellar operons in Vibrio cholerae O37 strain V52. Nucleic Acids Res. 2012;40:7766-75 pubmed publisher
    The alternative sigma factor RpoN is an essential colonization factor of Vibrio cholerae and controls important cellular functions including motility and type VI secretion (T6SS)...
  5. Marrero K, S nchez A, Gonz lez L, Led n T, Rodr guez Ulloa A, Castellanos Serra L, et al. Periplasmic proteins encoded by VCA0261-0260 and VC2216 genes together with copA and cueR products are required for copper tolerance but not for virulence in Vibrio cholerae. Microbiology. 2012;158:2005-16 pubmed publisher
    The bacterial pathogen Vibrio cholerae requires colonizination of the human small intestine to cause cholera...
  6. Blokesch M. Chitin colonization, chitin degradation and chitin-induced natural competence of Vibrio cholerae are subject to catabolite repression. Environ Microbiol. 2012;14:1898-912 pubmed publisher
    Although Vibrio cholerae is a human pathogen its primary habitat are aquatic environments. In this environment, V.cholerae takes advantage of the abundance of zooplankton, whose chitinous exoskeletons provide a nutritious surface...
  7. Lai C, Liu W, Chiu Y, Gau S, Hsueh P. Spontaneous bacterial empyema due to non-O1, non-O139 Vibrio cholerae in a cirrhotic patient with hepatocellular carcinoma. Diagn Microbiol Infect Dis. 2012;73:84-5 pubmed publisher
    b>Vibrio cholerae is known as a common etiology of epidemic diarrheal disease and rarely causes extra-intestinal infections...
  8. Zhao X, Koestler B, Waters C, Hammer B. Post-transcriptional activation of a diguanylate cyclase by quorum sensing small RNAs promotes biofilm formation in Vibrio cholerae. Mol Microbiol. 2013;89:989-1002 pubmed publisher
    Biofilms promote attachment of Vibrio cholerae in aquatic ecosystems and aid in transmission...
  9. Wyckoff E, Payne S. The Vibrio cholerae VctPDGC system transports catechol siderophores and a siderophore-free iron ligand. Mol Microbiol. 2011;81:1446-58 pubmed publisher
    b>Vibrio cholerae, the causative agent of cholera, has an absolute requirement for iron. It transports the catechol siderophores vibriobactin, which it synthesizes and secretes, and enterobactin...

More Information

Publications81

  1. Pickering B, Smith D, Watnick P. Glucose-specific enzyme IIA has unique binding partners in the vibrio cholerae biofilm. MBio. 2012;3:e00228-12 pubmed publisher
    ..We previously reported that EIIA(Glc) activates transcription of the genes required for Vibrio cholerae biofilm formation...
  2. Dutta D, Chowdhury G, Pazhani G, Guin S, Dutta S, Ghosh S, et al. Vibrio cholerae non-O1, non-O139 serogroups and cholera-like diarrhea, Kolkata, India. Emerg Infect Dis. 2013;19:464-7 pubmed publisher
    We identified 281 Vibrio cholerae non-O1, non-O139 strains from patients with diarrhea in Kolkata, India. Cholera-like diarrhea was the major symptom (66.0%); some patients (20.3%) had severe dehydration...
  3. Fu Y, Waldor M, Mekalanos J. Tn-Seq analysis of Vibrio cholerae intestinal colonization reveals a role for T6SS-mediated antibacterial activity in the host. Cell Host Microbe. 2013;14:652-63 pubmed publisher
    ..genes required for host infection will provide clues to the drivers of evolutionary fitness of pathogens like Vibrio cholerae, a mounting threat to global heath...
  4. Johnson Z, Cheong C, Lee S. Crystal structure of a concentrative nucleoside transporter from Vibrio cholerae at 2.4?Å. Nature. 2012;483:489-93 pubmed publisher
    ..Here we present the crystal structure of a concentrative nucleoside transporter from Vibrio cholerae in complex with uridine at 2.4?Å...
  5. Brooks T, Unterweger D, Bachmann V, Kostiuk B, Pukatzki S. Lytic activity of the Vibrio cholerae type VI secretion toxin VgrG-3 is inhibited by the antitoxin TsaB. J Biol Chem. 2013;288:7618-25 pubmed publisher
    ..Here, we present evidence that VgrG-3 of the Vibrio cholerae T6SS has both structural and toxin activity...
  6. Goss T, Morgan S, French E, Krukonis E. ToxR recognizes a direct repeat element in the toxT, ompU, ompT, and ctxA promoters of Vibrio cholerae to regulate transcription. Infect Immun. 2013;81:884-95 pubmed publisher
    ToxR facilitates TcpP-mediated activation of the toxT promoter in Vibrio cholerae, initiating a regulatory cascade that culminates in cholera toxin secretion and toxin coregulated pilus expression...
  7. Basler M, Ho B, Mekalanos J. Tit-for-tat: type VI secretion system counterattack during bacterial cell-cell interactions. Cell. 2013;152:884-94 pubmed publisher
    ..We show that, in the case of P. aeruginosa, T6SS-dependent killing of either Vibrio cholerae or Acinetobacter baylyi is greatly stimulated by T6SS activity occurring in those prey species...
  8. Chowdhury N, Norris J, McAlister E, Lau S, Thomas G, Boyd E. The VC1777-VC1779 proteins are members of a sialic acid-specific subfamily of TRAP transporters (SiaPQM) and constitute the sole route of sialic acid uptake in the human pathogen Vibrio cholerae. Microbiology. 2012;158:2158-67 pubmed publisher
    ..b>Vibrio cholerae contains a tripartite ATP-independent periplasmic (TRAP) transporter, SiaPQM (VC1777-VC1779), encoded by ..
  9. Yang M, Liu Z, Hughes C, Stern A, Wang H, Zhong Z, et al. Bile salt-induced intermolecular disulfide bond formation activates Vibrio cholerae virulence. Proc Natl Acad Sci U S A. 2013;110:2348-53 pubmed publisher
    ..By directly applying a reporter strain of Vibrio cholerae, the causative agent of cholera, to a thin layer chromatography (TLC) plate containing mouse intestinal ..
  10. Sarkar M, Bhowmick S, Casola A, Chaudhuri K. Interleukin-8 gene regulation in epithelial cells by Vibrio cholerae: role of multiple promoter elements, adherence and motility of bacteria and host MAPKs. FEBS J. 2012;279:1464-73 pubmed publisher
    ..We previously demonstrated that incubation of intestinal epithelial cells with Vibrio cholerae O395 resulted in increased IL-8 mRNA expression and IL-8 secretion, which was associated with the adherence ..
  11. Shea M, Juárez O, Cho J, Barquera B. Aspartic acid 397 in subunit B of the Na+-pumping NADH:quinone oxidoreductase from Vibrio cholerae forms part of a sodium-binding site, is involved in cation selectivity, and affects cation-binding site cooperativity. J Biol Chem. 2013;288:31241-9 pubmed publisher
    The Na(+)-pumping NADH:quinone complex is found in Vibrio cholerae and other marine and pathogenic bacteria...
  12. Dittmer J, Withey J. Identification and characterization of the functional toxboxes in the Vibrio cholerae cholera toxin promoter. J Bacteriol. 2012;194:5255-63 pubmed publisher
    Following the consumption of contaminated food or water by a human host, the Vibrio cholerae bacterium produces virulence factors, including cholera toxin (CT), which directly causes voluminous diarrhea, producing cholera...
  13. Tiaden A, Hilbi H. ?-Hydroxyketone synthesis and sensing by Legionella and Vibrio. Sensors (Basel). 2012;12:2899-919 pubmed publisher
    ..AHKs), is produced and detected by the water-borne opportunistic pathogens Legionella pneumophila and Vibrio cholerae, which cause Legionnaires' disease and cholera, respectively...
  14. Ganguly S, Mukherjee A, Mazumdar B, Ghosh A, Banerjee K. The ?-prism lectin domain of Vibrio cholerae hemolysin promotes self-assembly of the ?-pore-forming toxin by a carbohydrate-independent mechanism. J Biol Chem. 2014;289:4001-8 pubmed publisher
    b>Vibrio cholerae cytolysin/hemolysin (VCC) is an amphipathic 65-kDa ?-pore-forming toxin with a C-terminal ?-prism lectin domain...
  15. Hankins J, Madsen J, Giles D, Brodbelt J, Trent M. Amino acid addition to Vibrio cholerae LPS establishes a link between surface remodeling in gram-positive and gram-negative bacteria. Proc Natl Acad Sci U S A. 2012;109:8722-7 pubmed publisher
    Historically, the O1 El Tor and classical biotypes of Vibrio cholerae have been differentiated by their resistance to the antimicrobial peptide polymyxin B...
  16. Nishiyama S, Suzuki D, Itoh Y, Suzuki K, Tajima H, Hyakutake A, et al. Mlp24 (McpX) of Vibrio cholerae implicated in pathogenicity functions as a chemoreceptor for multiple amino acids. Infect Immun. 2012;80:3170-8 pubmed publisher
    The chemotaxis of Vibrio cholerae, the causative agent of cholera, has been implicated in pathogenicity. The bacterium has more than 40 genes for methyl-accepting chemotaxis protein (MCP)-like proteins (MLPs)...
  17. Sahu S, Lewis J, Patel I, Bozdag S, Lee J, Leclerc J, et al. Genomic analysis of immune response against Vibrio cholerae hemolysin in Caenorhabditis elegans. PLoS ONE. 2012;7:e38200 pubmed publisher
    b>Vibrio cholerae cytolysin (VCC) is among the accessory V. cholerae virulence factors that may contribute to disease pathogenesis in humans...
  18. Lam C, Octavia S, Reeves P, Lan R. Multi-locus variable number tandem repeat analysis of 7th pandemic Vibrio cholerae. BMC Microbiol. 2012;12:82 pubmed publisher
    ..In this study we use multilocus variable number of tandem repeats (VNTRs) analysis (MLVA) to discriminate between isolates of the 7th pandemic clone of Vibrio cholerae.
  19. Li J, Egelman E, Craig L. Structure of the Vibrio cholerae Type IVb Pilus and stability comparison with the Neisseria gonorrhoeae type IVa pilus. J Mol Biol. 2012;418:47-64 pubmed publisher
    ..for the Type IVa GC pilus from Neisseria gonorrhoeae and the Type IVb toxin-coregulated pilus (TCP) from Vibrio cholerae. We show that while recombinant TCP pilin is more stable than GC pilin, the GC pili are more resistant to ..
  20. Devault A, Golding G, Waglechner N, Enk J, Kuch M, Tien J, et al. Second-pandemic strain of Vibrio cholerae from the Philadelphia cholera outbreak of 1849. N Engl J Med. 2014;370:334-40 pubmed publisher
    ..We used targeted high-throughput sequencing to reconstruct the Vibrio cholerae genome from the preserved intestine of a victim of the 1849 cholera outbreak in Philadelphia, part of the ..
  21. Wang Z, Berkey C, Watnick P. The Drosophila protein mustard tailors the innate immune response activated by the immune deficiency pathway. J Immunol. 2012;188:3993-4000 pubmed publisher
    In this study, we describe a Drosophila melanogaster transposon insertion mutant with tolerance to Vibrio cholerae infection and markedly decreased transcription of diptericin as well as other genes regulated by the immune deficiency ..
  22. Juárez O, Neehaul Y, Turk E, Chahboun N, Demicco J, Hellwig P, et al. The role of glycine residues 140 and 141 of subunit B in the functional ubiquinone binding site of the Na+-pumping NADH:quinone oxidoreductase from Vibrio cholerae. J Biol Chem. 2012;287:25678-85 pubmed publisher
    ..Moreover, mutations in residue NqrB-G140 almost completely abolished the electron transfer to ubiquinone. Thus, NqrB-G140 and -G141 are critical for the binding and reaction of Na(+)-NQR with its electron acceptor, ubiquinone...
  23. Koestler B, Waters C. Exploring environmental control of cyclic di-GMP signaling in Vibrio cholerae by using the ex vivo lysate cyclic di-GMP assay (TELCA). Appl Environ Microbiol. 2013;79:5233-41 pubmed publisher
    b>Vibrio cholerae senses its environment, including the surrounding bacterial community, using both the second messenger cyclic di-GMP (c-di-GMP) and quorum sensing (QS) to regulate biofilm formation and other bacterial behaviors...
  24. Islam A, Labbate M, Djordjevic S, Alam M, Darling A, Melvold J, et al. Indigenous Vibrio cholerae strains from a non-endemic region are pathogenic. Open Biol. 2013;3:120181 pubmed publisher
    Of the 200+ serogroups of Vibrio cholerae, only O1 or O139 strains are reported to cause cholera, and mostly in endemic regions. Cholera outbreaks elsewhere are considered to be via importation of pathogenic strains...
  25. Koch B, Ma X, Løbner Olesen A. rctB mutations that increase copy number of Vibrio cholerae oriCII in Escherichia coli. Plasmid. 2012;68:159-69 pubmed publisher
    RctB serves as the initiator protein for replication from oriCII, the origin of replication of Vibrio cholerae chromosome II...
  26. Moisi M, Lichtenegger S, Tutz S, Seper A, Schild S, Reidl J. Characterizing the hexose-6-phosphate transport system of Vibrio cholerae, a utilization system for carbon and phosphate sources. J Bacteriol. 2013;195:1800-8 pubmed publisher
    The facultative human pathogen Vibrio cholerae transits between the gastrointestinal tract of its host and aquatic reservoirs. V. cholerae adapts to different situations by the timely coordinated expression of genes during its life cycle...
  27. Baharoglu Z, Krin E, Mazel D. RpoS plays a central role in the SOS induction by sub-lethal aminoglycoside concentrations in Vibrio cholerae. PLoS Genet. 2013;9:e1003421 pubmed publisher
    ..coli, sub-minimal inhibitory concentrations (sub-MIC) of aminoglycosides (AGs) induce the SOS response in Vibrio cholerae. SOS is induced upon DNA damage, and since AGs do not directly target DNA, we addressed two issues in this ..
  28. Walden P, Heras B, Chen K, Halili M, Rimmer K, Sharma P, et al. The 1.2 Å resolution crystal structure of TcpG, the Vibrio cholerae DsbA disulfide-forming protein required for pilus and cholera-toxin production. Acta Crystallogr D Biol Crystallogr. 2012;68:1290-302 pubmed
    The enzyme TcpG is a periplasmic protein produced by the Gram-negative pathogen Vibrio cholerae. TcpG is essential for the production of ToxR-regulated proteins, including virulence-factor pilus proteins and cholera toxin, and is ..
  29. Awasthi S, Asakura M, Chowdhury N, Neogi S, Hinenoya A, Golbar H, et al. Novel cholix toxin variants, ADP-ribosylating toxins in Vibrio cholerae non-O1/non-O139 strains, and their pathogenicity. Infect Immun. 2013;81:531-41 pubmed publisher
    Cholix toxin (ChxA) is a recently discovered exotoxin in Vibrio cholerae which has been characterized as a third member of the eukaryotic elongation factor 2-specific ADP-ribosyltransferase toxins, in addition to exotoxin A of ..
  30. Seman M, Prokšová M, Rosinský J, Ferianc P. Isolation, identification, and characterization of Vibrio cholerae from the Danube River in Slovakia. Folia Microbiol (Praha). 2012;57:191-7 pubmed publisher
    The occurrence of Vibrio cholerae, an important aquatic pathogen, was assessed in the surface water of the Danube River near Bratislava...
  31. Bhowmick S, Chatterjee D, Chaudhuri K. Human epithelial cells stimulated with Vibrio cholerae produce thymic stromal lymphopoietin and promote dendritic cell-mediated inflammatory Th2 response. Int J Biochem Cell Biol. 2012;44:1779-90 pubmed publisher
    b>Vibrio cholerae induces acute inflammatory response at intestinal epithelial surface; the underlying cellular immune mechanisms for such effects are largely unexplored...
  32. Pande K, Mendiratta D, Vijayashri D, Thamke D, Narang P. SXT constin among Vibrio cholerae isolates from a tertiary care hospital. Indian J Med Res. 2012;135:346-50 pubmed
    ..conjugable, self transmissible, integrating element) is an integrating conjugative element (ICE) in Vibrio cholerae discovered in the chromosome of epidemic V...
  33. Ahrens S, Geissler B, Satchell K. Identification of a His-Asp-Cys catalytic triad essential for function of the Rho inactivation domain (RID) of Vibrio cholerae MARTX toxin. J Biol Chem. 2013;288:1397-408 pubmed publisher
    b>Vibrio cholerae is the causative agent of the severe diarrheal disease cholera. For V...
  34. Sharifnia A, Bakhshi B, Pourshafie M. wbeT sequence typing and IS1004 profiling of Vibrio cholerae isolates. Lett Appl Microbiol. 2012;54:267-71 pubmed publisher
    To investigate the molecular basis for serotype variation in Vibrio cholerae O1 and the genetic relatedness amongst different serotypes isolated from 2004 to 2008 in Iran.
  35. Thiramanas R, Jangpatarapongsa K, Tangboriboonrat P, Polpanich D. Detection of Vibrio cholerae using the intrinsic catalytic activity of a magnetic polymeric nanoparticle. Anal Chem. 2013;85:5996-6002 pubmed publisher
    ..chain reaction-colorimetry (magneto-PCR-colorimetry) technique was developed for detection of Vibrio cholerae ( V. cholerae ). The technique involved an amplification of V...
  36. Dörr T, Moll A, Chao M, Cava F, Lam H, Davis B, et al. Differential requirement for PBP1a and PBP1b in in vivo and in vitro fitness of Vibrio cholerae. Infect Immun. 2014;82:2115-24 pubmed publisher
    We investigated the roles of the Vibrio cholerae high-molecular-weight bifunctional penicillin binding proteins, PBP1a and PBP1b, in the fitness of this enteric pathogen. Using a screen for synthetic lethality, we found that the V...
  37. Liu S, Zhang C, Li N, Niu B, Liu M, Liu X, et al. Structural insight into the ISC domain of VibB from Vibrio cholerae at atomic resolution: a snapshot just before the enzymatic reaction. Acta Crystallogr D Biol Crystallogr. 2012;68:1329-38 pubmed
    ..The structural, biochemical and MD results reveal the residues that are involved in substrate binding and provide clues towards defining a possible mechanism...
  38. Basler M, Pilhofer M, Henderson G, Jensen G, Mekalanos J. Type VI secretion requires a dynamic contractile phage tail-like structure. Nature. 2012;483:182-6 pubmed publisher
    ..Here we show that protein secretion by the type VI secretion system of Vibrio cholerae requires the action of a dynamic intracellular tubular structure that is structurally and functionally ..
  39. Huff K, Aroonnual A, Littlejohn A, Rajwa B, Bae E, Banada P, et al. Light-scattering sensor for real-time identification of Vibrio parahaemolyticus, Vibrio vulnificus and Vibrio cholerae colonies on solid agar plate. Microb Biotechnol. 2012;5:607-20 pubmed publisher
    The three most common pathogenic species of Vibrio, Vibrio cholerae, Vibrio parahaemolyticus and Vibrio vulnificus, are of major concerns due to increased incidence of water- and seafood-related outbreaks and illness worldwide...
  40. Baharoglu Z, Krin E, Mazel D. Connecting environment and genome plasticity in the characterization of transformation-induced SOS regulation and carbon catabolite control of the Vibrio cholerae integron integrase. J Bacteriol. 2012;194:1659-67 pubmed publisher
    The human pathogen Vibrio cholerae carries a chromosomal superintegron (SI)...
  41. Taylor D, Bina X, Bina J. Vibrio cholerae VexH encodes a multiple drug efflux pump that contributes to the production of cholera toxin and the toxin co-regulated pilus. PLoS ONE. 2012;7:e38208 pubmed publisher
    ..Recent studies showed that RND systems were required for virulence factor production in Vibrio cholerae. The V. cholerae genome encodes six RND efflux systems...
  42. Quinn M, Resch C, Sun J, Lind E, Dibrov P, HASE C. NhaP1 is a K+(Na+)/H+ antiporter required for growth and internal pH homeostasis of Vibrio cholerae at low extracellular pH. Microbiology. 2012;158:1094-105 pubmed publisher
    b>Vibrio cholerae has adapted to a wide range of salinity, pH and osmotic conditions, enabling it to survive passage through the host and persist in the environment...
  43. Kiiru J, Mutreja A, Mohamed A, Kimani R, Mwituria J, Sanaya R, et al. A study on the geophylogeny of clinical and environmental Vibrio cholerae in Kenya. PLoS ONE. 2013;8:e74829 pubmed publisher
    ..cholerae isolated elsewhere in the world and similarly harbour antibiotic resistance-associated STX elements. Further, the Kenyan O1 El Tor isolates fall into two distinct clades that may have entered Kenya independently. ..
  44. Shlyapnikov Y, Shlyapnikova E, Simonova M, Shepelyakovskaya A, Brovko F, Komaleva R, et al. Rapid simultaneous ultrasensitive immunodetection of five bacterial toxins. Anal Chem. 2012;84:5596-603 pubmed publisher
    ..1-1 pg/mL for water and to 1 pg/mL for food samples...
  45. Adagbada A, Adesida S, Nwaokorie F, Niemogha M, Coker A. Cholera epidemiology in Nigeria: an overview. Pan Afr Med J. 2012;12:59 pubmed
    ..Based on existing relevant scientific literature on features of cholera, this paper presents a synopsis of cholera epidemiology emphasising the situation in Nigeria...
  46. Li N, Zhang C, Li B, Liu X, Huang Y, Xu S, et al. Unique iron coordination in iron-chelating molecule vibriobactin helps Vibrio cholerae evade mammalian siderocalin-mediated immune response. J Biol Chem. 2012;287:8912-9 pubmed publisher
    Iron is essential for the survival of almost all bacteria. Vibrio cholerae acquires iron through the secretion of a catecholate siderophore called vibriobactin. At present, how vibriobactin chelates ferric ion remains controversial...
  47. Barh D, Barve N, Gupta K, Chandra S, Jain N, Tiwari S, et al. Exoproteome and secretome derived broad spectrum novel drug and vaccine candidates in Vibrio cholerae targeted by Piper betel derived compounds. PLoS ONE. 2013;8:e52773 pubmed publisher
    b>Vibrio cholerae is the causal organism of the cholera epidemic, which is mostly prevalent in developing and underdeveloped countries. However, incidences of cholera in developed countries are also alarming...
  48. de Sá Morais L, Garza D, Loureiro E, Nunes K, Vellasco R, da Silva C, et al. Complete genome sequence of a sucrose-nonfermenting epidemic strain of Vibrio cholerae O1 from Brazil. J Bacteriol. 2012;194:2772 pubmed publisher
    We report the genome sequence of Vibrio cholerae strain IEC224, which fails to ferment sucrose. It was isolated from a cholera outbreak in the Amazon...
  49. Wang H, Ayala J, Benitez J, Silva A. The LuxR-type regulator VpsT negatively controls the transcription of rpoS, encoding the general stress response regulator, in Vibrio cholerae biofilms. J Bacteriol. 2014;196:1020-30 pubmed publisher
    Cholera is a waterborne diarrheal disease caused by Vibrio cholerae strains of serogroups O1 and O139. Expression of the general stress response regulator RpoS and formation of biofilm communities enhance the capacity of V...
  50. Jutla A, Whitcombe E, Hasan N, Haley B, Akanda A, Huq A, et al. Environmental factors influencing epidemic cholera. Am J Trop Med Hyg. 2013;89:597-607 pubmed publisher
    ..b>Vibrio cholerae is autochthonous to aquatic environment, hence, it cannot be eradicated but hydroclimatology-based prediction ..
  51. Mudrak B, Tamayo R. The Vibrio cholerae Pst2 phosphate transport system is upregulated in biofilms and contributes to biofilm-induced hyperinfectivity. Infect Immun. 2012;80:1794-802 pubmed publisher
    b>Vibrio cholerae is the causative agent of the deadly diarrheal disease cholera. As part of its life cycle, V. cholerae persists in marine environments, where it forms surface-attached communities commonly described as biofilms...
  52. Dolores J, Satchell K. Analysis of Vibrio cholerae genome sequences reveals unique rtxA variants in environmental strains and an rtxA-null mutation in recent altered El Tor isolates. MBio. 2013;4:e00624 pubmed publisher
    b>Vibrio cholerae genome sequences were analyzed for variation in the rtxA gene that encodes the multifunctional autoprocessing RTX (MARTX) toxin...
  53. Sakharwade S, Sharma P, Mukhopadhaya A. Vibrio cholerae porin OmpU induces pro-inflammatory responses, but down-regulates LPS-mediated effects in RAW 264.7, THP-1 and human PBMCs. PLoS ONE. 2013;8:e76583 pubmed publisher
    b>Vibrio cholerae porin OmpU plays a crucial role in the survival of the organism in the human gut. Various observations suggest critical involvement of OmpU in V. cholerae pathogenesis...
  54. Octavia S, Salim A, Kurniawan J, Lam C, Leung Q, Ahsan S, et al. Population structure and evolution of non-O1/non-O139 Vibrio cholerae by multilocus sequence typing. PLoS ONE. 2013;8:e65342 pubmed publisher
    Pathogenic non-O1/non-O139 Vibrio cholerae strains can cause sporadic outbreaks of cholera worldwide...
  55. Wholey W, Jakob U. Hsp33 confers bleach resistance by protecting elongation factor Tu against oxidative degradation in Vibrio cholerae. Mol Microbiol. 2012;83:981-91 pubmed publisher
    ..by which expression of Hsp33 confers resistance to oxidative protein unfolding conditions, we made use of Vibrio cholerae strain O395 lacking the Hsp33 gene hslO...
  56. Durand E, Derrez E, Audoly G, Spinelli S, Ortiz Lombardia M, Raoult D, et al. Crystal structure of the VgrG1 actin cross-linking domain of the Vibrio cholerae type VI secretion system. J Biol Chem. 2012;287:38190-9 pubmed publisher
    b>Vibrio cholerae is the cause of the diarrheal disease cholera. V...
  57. Wei Y, Ng W, Cong J, Bassler B. Ligand and antagonist driven regulation of the Vibrio cholerae quorum-sensing receptor CqsS. Mol Microbiol. 2012;83:1095-108 pubmed publisher
    ..a bacterial cell-cell communication process, controls biofilm formation and virulence factor production in Vibrio cholerae, a human pathogen that causes the disease cholera. The major V...
  58. Uchida T, Sekine Y, Matsui T, Ikeda Saito M, Ishimori K. A heme degradation enzyme, HutZ, from Vibrio cholerae. Chem Commun (Camb). 2012;48:6741-3 pubmed publisher
    HutZ, one of the crucial proteins of the iron uptake system in Vibrio cholerae, was purified, which binds to heme at a stoichiometry of 1 : 1...
  59. Roy S, Parande M, Mantur B, Bhat S, Shinde R, Parande A, et al. Multidrug-resistant Vibrio cholerae O1 in Belgaum, south India. J Med Microbiol. 2012;61:1574-9 pubmed publisher
    ..An estimated 16.22?% of people were affected and 0.16?% deaths were reported. Vibrio cholerae O1 El Tor was isolated from 18 of the 147 stool samples cultured...
  60. Luo Y, Ye J, Jin D, Ding G, Zhang Z, Mei L, et al. Molecular analysis of non-O1/non-O139 Vibrio cholerae isolated from hospitalised patients in China. BMC Microbiol. 2013;13:52 pubmed publisher
    Cholera is still a significant public health issue in developing countries. The aetiological agent is Vibrio cholerae and only two serogroups, O1 and O139, are known to cause pandemic or epidemic cholera. In contrast, non-O1/non-O139 V...
  61. Jubair M, Morris J, Ali A. Survival of Vibrio cholerae in nutrient-poor environments is associated with a novel "persister" phenotype. PLoS ONE. 2012;7:e45187 pubmed publisher
    ..Although toxigenic Vibrio cholerae, responsible for the disease cholera, can be found in nutrient-poor aquatic environments in endemic areas, ..
  62. Xu J, Zhang J, Lu X, Liang W, Zhang L, Kan B. O antigen is the receptor of Vibrio cholerae serogroup O1 El Tor typing phage VP4. J Bacteriol. 2013;195:798-806 pubmed publisher
    Bacteriophage VP4 is a lytic phage of the Vibrio cholerae serogroup O1, and it is used in phage subtyping of V. cholerae biotype El Tor...
  63. Dong T, Ho B, Yoder Himes D, Mekalanos J. Identification of T6SS-dependent effector and immunity proteins by Tn-seq in Vibrio cholerae. Proc Natl Acad Sci U S A. 2013;110:2623-8 pubmed publisher
    ..approach using transposon mutagenesis and deep sequencing (Tn-seq) to identify T6SS immunity proteins in Vibrio cholerae. Saturating transposon mutagenesis was performed in wild type and a T6SS null mutant...
  64. Faruque S, Mekalanos J. Phage-bacterial interactions in the evolution of toxigenic Vibrio cholerae. Virulence. 2012;3:556-65 pubmed publisher
    ..b>Vibrio cholerae the causative agent of cholera epidemics represents a paradigm for this process in that this organism evolved ..
  65. Wong E, Vaaje Kolstad G, Ghosh A, Hurtado Guerrero R, Konarev P, Ibrahim A, et al. The Vibrio cholerae colonization factor GbpA possesses a modular structure that governs binding to different host surfaces. PLoS Pathog. 2012;8:e1002373 pubmed publisher
    b>Vibrio cholerae is a bacterial pathogen that colonizes the chitinous exoskeleton of zooplankton as well as the human gastrointestinal tract...
  66. Seitz P, Blokesch M. DNA-uptake machinery of naturally competent Vibrio cholerae. Proc Natl Acad Sci U S A. 2013;110:17987-92 pubmed publisher
    ..Here, we report the visualization of a competence-induced pilus in the Gram-negative bacterium Vibrio cholerae. We show that piliated cells mostly contain a single pilus that is not biased toward a polar localization and ..
  67. Patra T, Koley H, Ramamurthy T, Ghose A, Nandy R. The Entner-Doudoroff pathway is obligatory for gluconate utilization and contributes to the pathogenicity of Vibrio cholerae. J Bacteriol. 2012;194:3377-85 pubmed publisher
    ..for many organisms although very little information is available on the functionality of this pathway in Vibrio cholerae, the causative agent of cholera...
  68. Vincent H, Henderson C, Ragan T, Garza Garcia A, Cary P, Gowers D, et al. Characterization of Vibrio cholerae Hfq provides novel insights into the role of the Hfq C-terminal region. J Mol Biol. 2012;420:56-69 pubmed publisher
    ..In Vibrio cholerae, Hfq and four Hfq-dependent small RNAs are essential for the expression of virulence genes, but little is ..
  69. Sun S, Kjelleberg S, McDougald D. Relative contributions of Vibrio polysaccharide and quorum sensing to the resistance of Vibrio cholerae to predation by heterotrophic protists. PLoS ONE. 2013;8:e56338 pubmed publisher
    Protozoan grazing is a major mortality factor faced by bacteria in the environment. Vibrio cholerae, the causative agent of the disease cholera, is a natural inhabitant of aquatic ecosystems, and its survival depends on its ability to ..
  70. Lee K, Park Y, Bari W, Yoon M, Go J, Kim S, et al. Activation of cholera toxin production by anaerobic respiration of trimethylamine N-oxide in Vibrio cholerae. J Biol Chem. 2012;287:39742-52 pubmed publisher
    b>Vibrio cholerae is a gram-negative bacterium that causes cholera...
  71. Nedielkov R, Steffen W, Steuber J, Möller H. NMR reveals double occupancy of quinone-type ligands in the catalytic quinone binding site of the Na+-translocating NADH:Quinone oxidoreductase from Vibrio cholerae. J Biol Chem. 2013;288:30597-606 pubmed publisher
    The sodium ion-translocating NADH:quinone oxidoreductase (Na(+)-NQR) from the pathogen Vibrio cholerae exploits the free energy liberated during oxidation of NADH with ubiquinone to pump sodium ions across the cytoplasmic membrane...
  72. Davies B, Bogard R, Young T, Mekalanos J. Coordinated regulation of accessory genetic elements produces cyclic di-nucleotides for V. cholerae virulence. Cell. 2012;149:358-70 pubmed publisher
    ..cholerae, and implicates its occurrence in 7(th) pandemic strains as a benefit for host adaptation through the production of a regulatory cyclic di-nucleotide...