streptococcus suis

Summary

Summary: A species of STREPTOCOCCUS isolated from pigs. It is a pathogen of swine but rarely occurs in humans.

Top Publications

  1. van de Beek D, Spanjaard L, de Gans J. Streptococcus suis meningitis in the Netherlands. J Infect. 2008;57:158-61 pubmed publisher
    We present four patients with Streptococcus suis meningitis identified during a 3.5-year prospective surveillance study in the Netherlands. All cases were associated with exposure to pigs...
  2. Segura M, Gottschalk M, Olivier M. Encapsulated Streptococcus suis inhibits activation of signaling pathways involved in phagocytosis. Infect Immun. 2004;72:5322-30 pubmed
    b>Streptococcus suis capsular type 2 is an important zoonotic agent of meningitis. Previous studies reported that, in contrast to nonencapsulated mutants, encapsulated S. suis is able to resist phagocytosis...
  3. Cheung P, Lo K, Cheung T, Yeung W, Leung P, Kam K. Streptococcus suis in retail markets: how prevalent is it in raw pork?. Int J Food Microbiol. 2008;127:316-20 pubmed publisher
    b>Streptococcus suis present in raw pork meats sold in local retail markets was enumerated by Most Probable Number (MPN)-PCR method...
  4. Haikarainen T, Thanassoulas A, Stavros P, Nounesis G, Haataja S, Papageorgiou A. Structural and thermodynamic characterization of metal ion binding in Streptococcus suis Dpr. J Mol Biol. 2011;405:448-60 pubmed publisher
    ..The results presented here demonstrate the ability of SsDpr to bind various metals as substitutes for iron and will help in better understanding protein-metal interactions in the Dps family of proteins as potential metal nanocontainers. ..
  5. Wang Y, Gagnon C, Savard C, Music N, Srednik M, Segura M, et al. Capsular sialic acid of Streptococcus suis serotype 2 binds to swine influenza virus and enhances bacterial interactions with virus-infected tracheal epithelial cells. Infect Immun. 2013;81:4498-508 pubmed publisher
    b>Streptococcus suis serotype 2 is an important swine bacterial pathogen, and it is also an emerging zoonotic agent. It is unknown how S...
  6. Ma E, Chung P, So T, Wong L, Choi K, Cheung D, et al. Streptococcus suis infection in Hong Kong: an emerging infectious disease?. Epidemiol Infect. 2008;136:1691-7 pubmed publisher
    We conducted a 31-month retrospective review of all laboratory-confirmed Streptococcus suis infections admitted to public hospitals in Hong Kong. Strain identification, serotyping and antibiotic susceptibility tests were conducted on S...
  7. Hu P, Yang M, Zhang A, Wu J, Chen B, Hua Y, et al. Complete genome sequence of Streptococcus suis serotype 14 strain JS14. J Bacteriol. 2011;193:2375-6 pubmed publisher
    b>Streptococcus suis is an important zoonotic agent leading to a variety of diseases in swine and can be transmitted to human beings upon close contact. Here, we report the complete genome sequence of S...
  8. Takeuchi D, Kerdsin A, Pienpringam A, Loetthong P, Samerchea S, Luangsuk P, et al. Population-based study of Streptococcus suis infection in humans in Phayao Province in northern Thailand. PLoS ONE. 2012;7:e31265 pubmed publisher
    b>Streptococcus suis infection in humans has received increasing worldwide recognition.
  9. Tang J, Wang C, Feng Y, Yang W, Song H, Chen Z, et al. Streptococcal toxic shock syndrome caused by Streptococcus suis serotype 2. PLoS Med. 2006;3:e151 pubmed
    b>Streptococcus suis serotype 2 (S. suis 2, SS2) is a major zoonotic pathogen that causes only sporadic cases of meningitis and sepsis in humans...

More Information

Publications112 found, 100 shown here

  1. Hendriksen R, Mevius D, Schroeter A, Teale C, Jouy E, Butaye P, et al. Occurrence of antimicrobial resistance among bacterial pathogens and indicator bacteria in pigs in different European countries from year 2002 - 2004: the ARBAO-II study. Acta Vet Scand. 2008;50:19 pubmed publisher
    ..data from 17,642 isolates of pathogens and indicator bacteria including Actinobacillus pleuropneumoniae, Streptococcus suis and Escherichia coli isolated from pigs were collected from fifteen European countries in 2002-2004...
  2. Wangkaew S, Chaiwarith R, Tharavichitkul P, Supparatpinyo K. Streptococcus suis infection: a series of 41 cases from Chiang Mai University Hospital. J Infect. 2006;52:455-60 pubmed
    The objectives of this study were (1) to assess the clinical manifestations, treatment, and outcome of Streptococcus suis infection in adult patients in northern Thailand, (2) to evaluate the anti-microbial sensitivity pattern and (3) to ..
  3. Vanier G, Fittipaldi N, Slater J, de la Cruz Dominguez Punaro M, Rycroft A, Segura M, et al. New putative virulence factors of Streptococcus suis involved in invasion of porcine brain microvascular endothelial cells. Microb Pathog. 2009;46:13-20 pubmed publisher
    b>Streptococcus suis serotype 2 is an important pathogen causing a wide range of infections in swine, the most important being meningitis. Few virulence factors have been identified and the pathogenesis of infection is not well understood...
  4. Van Calsteren M, Gagnon F, Lacouture S, Fittipaldi N, Gottschalk M. Structure determination of Streptococcus suis serotype 2 capsular polysaccharide. Biochem Cell Biol. 2010;88:513-25 pubmed publisher
    The capsular polysaccharide (CPS) of Streptococcus suis serotype 2 was isolated, purified, chemically modified, and characterized...
  5. Wang K, Fan W, Cai L, Huang B, Lu C. Genetic analysis of the capsular polysaccharide synthesis locus in 15 Streptococcus suis serotypes. FEMS Microbiol Lett. 2011;324:117-24 pubmed publisher
    The capsular polysaccharide (CPS) synthesis locus of 13 Streptococcus suis serotypes (serotype 1, 3, 4, 5, 7, 8, 9, 10, 14, 19, 23, 25 and 1/2) was sequenced and compared with that of serotype 2 and 16...
  6. Li Y, Gottschalk M, Esgleas M, Lacouture S, Dubreuil J, Willson P, et al. Immunization with recombinant Sao protein confers protection against Streptococcus suis infection. Clin Vaccine Immunol. 2007;14:937-43 pubmed
    Sao is a Streptococcus suis surface protein recently identified as a potential vaccine candidate. In this study, recombinant Sao in combination with Quil A provided cross-protection against S...
  7. Esgleas M, Li Y, Hancock M, Harel J, Dubreuil J, Gottschalk M. Isolation and characterization of alpha-enolase, a novel fibronectin-binding protein from Streptococcus suis. Microbiology. 2008;154:2668-79 pubmed publisher
    b>Streptococcus suis is an important swine pathogen that causes meningitis, endocarditis, arthritis and septicaemia. As a zoonotic agent, S. suis also causes similar diseases in humans...
  8. Tenenbaum T, Papandreou T, Gellrich D, Friedrichs U, Seibt A, Adam R, et al. Polar bacterial invasion and translocation of Streptococcus suis across the blood-cerebrospinal fluid barrier in vitro. Cell Microbiol. 2009;11:323-36 pubmed publisher
    Previous experimental studies in a standard Transwell culture system have shown Streptococcus suis ability to compromise barrier function of porcine choroid plexus epithelial cells (PCPEC)...
  9. Zhang Q, Peng H, Gao F, Liu Y, Cheng H, Thompson J, et al. Structural insight into the catalytic mechanism of gluconate 5-dehydrogenase from Streptococcus suis: Crystal structures of the substrate-free and quaternary complex enzymes. Protein Sci. 2009;18:294-303 pubmed publisher
    ..To this end, we herein report the crystal structures of Ga5DH from pathogenic Streptococcus suis serotype 2 in both substrate-free and liganded (NADP(+)/D-gluconate/metal ion) quaternary complex forms at 2...
  10. Fittipaldi N, Collis T, Prothero B, Gottschalk M. Streptococcus suis meningitis, Hawaii. Emerg Infect Dis. 2009;15:2067-9 pubmed publisher
  11. Li W, Ye C, Jing H, Cui Z, Bai X, Jin D, et al. Streptococcus suis outbreak investigation using multiple-locus variable tandem repeat number analysis. Microbiol Immunol. 2010;54:380-8 pubmed publisher
    Two outbreaks of Streptococcus suis ST7 occurred in humans in 1998 and 2005 in China. PFGE of chromosome restriction fragments found all ST7 isolates to be indistinguishable...
  12. Meng X, Shi Y, Ji W, Meng X, Zhang J, Wang H, et al. Application of a bacteriophage lysin to disrupt biofilms formed by the animal pathogen Streptococcus suis. Appl Environ Microbiol. 2011;77:8272-9 pubmed publisher
    ..b>Streptococcus suis is an important pathogen of pigs, and here the biofilm-forming ability of 32 strains of this species was ..
  13. Zhang A, Chen B, Mu X, Zhao Y, Zheng P, Chen H, et al. Identification of three novel in vivo-induced expressed antigens during infection with Streptococcus suis serotype 2. FEMS Microbiol Lett. 2009;295:17-22 pubmed publisher
    b>Streptococcus suis serotype 2 (SS2) is a porcine and human pathogen with adhesive and invasive properties. The shortage of studies on the pathogenesis mechanisms of SS2 has made it very difficult to control infection with this pathogen...
  14. Zhang C, Ning Y, Zhang Z, Song L, Qiu H, Gao H, et al. [Distributions of pathogenic capsular types and in vitro antimicrobial susceptibility of different serotypes of Streptococcus suis isolated from clinically healthy sows from 10 provinces in China]. Zhonghua Liu Xing Bing Xue Za Zhi. 2009;30:235-8 pubmed
    ..of major pathogenic capsular types and in vitro antimicrobial susceptibility of different serotypes of Streptococcus suis isolated from clinically healthy sows in China...
  15. Wang Y, Zhang W, Wu Z, Zhu X, Lu C. Functional analysis of luxS in Streptococcus suis reveals a key role in biofilm formation and virulence. Vet Microbiol. 2011;152:151-60 pubmed publisher
    b>Streptococcus suis (SS) is an important pathogen of pigs, responsible for diverse diseases in swine and human...
  16. Seitz M, Baums C, Neis C, Benga L, Fulde M, Rohde M, et al. Subcytolytic effects of suilysin on interaction of Streptococcus suis with epithelial cells. Vet Microbiol. 2013;167:584-91 pubmed publisher
    Suilysin is a pore-forming cholesterol-dependent cytolysin secreted by Streptococcus suis (S. suis), an important swine and zoonotic pathogen. The role of suilysin in S. suis host-cell interaction is still unclear...
  17. Berthelot Hérault F, Gottschalk M, Morvan H, Kobisch M. Dilemma of virulence of Streptococcus suis: Canadian isolate 89-1591 characterized as a virulent strain using a standardized experimental model in pigs. Can J Vet Res. 2005;69:236-40 pubmed
    ..Using conventional animals, with an unknown status regarding previous S. suis infections, equivocal results may be obtained, and this may explain differences reported by some authors with the same strain. ..
  18. Wilson T, Jeffers J, Rapp Gabrielson V, Martin S, Klein L, Lowery D, et al. A novel signature-tagged mutagenesis system for Streptococcus suis serotype 2. Vet Microbiol. 2007;122:135-45 pubmed
    b>Streptococcus suis is an economically important, zoonotic pathogen causing death and disease in swine. The objectives of this study were to develop a signature-tagged mutagenesis (STM) system for S...
  19. Zheng H, Ye C, Segura M, Gottschalk M, Xu J. Mitogenic effect contributes to increased virulence of Streptococcus suis sequence type 7 to cause streptococcal toxic shock-like syndrome. Clin Exp Immunol. 2008;153:385-91 pubmed publisher
    b>Streptococcus suis serotype 2 sequence type 7 strains emerged in 1996 and caused a streptococcal toxic shock-like syndrome in 1998 and 2005 in China. Evidence indicated that the virulence of S...
  20. Fittipaldi N, Sekizaki T, Takamatsu D, de la Cruz Dominguez Punaro M, Harel J, Bui N, et al. Significant contribution of the pgdA gene to the virulence of Streptococcus suis. Mol Microbiol. 2008;70:1120-35 pubmed publisher
    b>Streptococcus suis is a major swine pathogen and emerging zoonotic agent. In this study we have determined the muropeptide composition of S. suis peptidoglycan (PG) and found, among other modifications, N-deacetylated compounds...
  21. Brassard J, Gottschalk M, Quessy S. Cloning and purification of the Streptococcus suis serotype 2 glyceraldehyde-3-phosphate dehydrogenase and its involvement as an adhesin. Vet Microbiol. 2004;102:87-94 pubmed publisher
    b>Streptococcus suis serotype 2 is a swine pathogen responsible for diverse diseases and may be present in the tonsils of pigs which show no sign of illness...
  22. Wang G, Zeng Y, Liu H, Xiong Z. An outbreak of Streptococcus suis in Chengdu, China. Int J Clin Pract. 2007;61:1056-7 pubmed
  23. Aranda J, Garrido M, Fittipaldi N, Cortés P, Llagostera M, Gottschalk M, et al. Protective capacities of cell surface-associated proteins of Streptococcus suis mutants deficient in divalent cation-uptake regulators. Microbiology. 2009;155:1580-7 pubmed publisher
    ..In this work, two Streptococcus suis divalent cation uptake regulator genes controlling zinc/manganese and iron uptake (adcR and fur, ..
  24. Gottschalk M, Segura M, Xu J. Streptococcus suis infections in humans: the Chinese experience and the situation in North America. Anim Health Res Rev. 2007;8:29-45 pubmed
    Infections caused by Streptococcus suis are considered a global problem in the swine industry. In this animal species, S. suis is associated with septicemia, meningitis, endocarditis, arthritis and, occasionally, other infections...
  25. Wertheim H, Nguyen H, Taylor W, Lien T, Ngo H, Nguyen T, et al. Streptococcus suis, an important cause of adult bacterial meningitis in northern Vietnam. PLoS ONE. 2009;4:e5973 pubmed publisher
    b>Streptococcus suis can cause severe systemic infection in adults exposed to infected pigs or after consumption of undercooked pig products. S. suis is often misdiagnosed, due to lack of awareness and improper testing...
  26. Zhang A, Mu X, Chen B, Han L, Chen H, Jin M. IgA1 protease contributes to the virulence of Streptococcus suis. Vet Microbiol. 2011;148:436-9 pubmed publisher
    b>Streptococcus suis (S. suis) is a major swine pathogen and emerging zoonotic agent. However, the current understanding of the S. suis pathogenesis of infection remains limited...
  27. Kerdsin A, Dejsirilert S, Puangpatra P, Sripakdee S, Chumla K, Boonkerd N, et al. Genotypic profile of Streptococcus suis serotype 2 and clinical features of infection in humans, Thailand. Emerg Infect Dis. 2011;17:835-42 pubmed publisher
    To examine associations between clinical features of Streptococcus suis serotype 2 infections in humans in Thailand and genotypic profiles of isolates, we conducted a retrospective study during 2006-2008...
  28. Luey C, Chu Y, Cheung T, Law C, Chu M, Cheung D, et al. Rapid pulsed-field gel electrophoresis protocol for subtyping of Streptococcus suis serotype 2. J Microbiol Methods. 2007;68:648-50 pubmed
    A rapid pulsed-field gel electrophoresis (PFGE) protocol for subtyping of Streptococcus suis serotype 2 was developed and evaluated using 27 clinical isolates from 22 epidemiologically unrelated patients...
  29. Geng H, Zhu L, Yuan Y, Zhang W, Li W, Wang J, et al. Identification and characterization of novel immunogenic proteins of Streptococcus suis serotype 2. J Proteome Res. 2008;7:4132-42 pubmed publisher
    b>Streptococcus suis, a zoonotic pathogen, caused serious outbreaks in humans with high mortality rates in the past decade...
  30. Esgleas M, Dominguez Punaro M, Li Y, Harel J, Dubreuil J, Gottschalk M. Immunization with SsEno fails to protect mice against challenge with Streptococcus suis serotype 2. FEMS Microbiol Lett. 2009;294:82-8 pubmed publisher
    In our ongoing efforts to develop a vaccine against Streptococcus suis infection, we tested the potential of S. suis enolase (SsEno), a recently described S...
  31. Wang H, Shen X, Zhao Y, Wang M, Zhong Q, Chen T, et al. Identification and proteome analysis of the two-component VirR/VirS system in epidemic Streptococcus suis serotype 2. FEMS Microbiol Lett. 2012;333:160-8 pubmed publisher
    b>Streptococcus suis serotype 2 (SS2) is an important zoonotic pathogen that infects pigs and sporadically causes serious infections in humans...
  32. Hill J, Gottschalk M, Brousseau R, Harel J, Hemmingsen S, Goh S. Biochemical analysis, cpn60 and 16S rDNA sequence data indicate that Streptococcus suis serotypes 32 and 34, isolated from pigs, are Streptococcus orisratti. Vet Microbiol. 2005;107:63-9 pubmed
    b>Streptococcus suis serotypes have traditionally been identified by morphology, biochemical profiling and serotyping. Analysis of the sequences of 16S rRNA and cpn60 genes of the 35 characterized serotypes of S...
  33. Chabot Roy G, Willson P, Segura M, Lacouture S, Gottschalk M. Phagocytosis and killing of Streptococcus suis by porcine neutrophils. Microb Pathog. 2006;41:21-32 pubmed
    b>Streptococcus suis serotype 2 is an important swine pathogen responsible for diverse infections, mainly meningitis. Virulence factors and the pathogenesis of infection are not well understood...
  34. Dominguez Punaro M, Segura M, Contreras I, Lachance C, Houde M, Lecours M, et al. In vitro characterization of the microglial inflammatory response to Streptococcus suis, an important emerging zoonotic agent of meningitis. Infect Immun. 2010;78:5074-85 pubmed publisher
    b>Streptococcus suis is an important swine and human pathogen responsible for septicemia and meningitis. In vivo research in mice suggested that in the brain, microglia might be involved in activating the inflammatory response against S...
  35. Okura M, Takamatsu D, Maruyama F, Nozawa T, Nakagawa I, Osaki M, et al. Genetic analysis of capsular polysaccharide synthesis gene clusters from all serotypes of Streptococcus suis: potential mechanisms for generation of capsular variation. Appl Environ Microbiol. 2013;79:2796-806 pubmed publisher
    b>Streptococcus suis strains are classified into 35 serotypes on the basis of the antigenicity of their capsular polysaccharides (CPs). CP synthesis genes are known to be clustered on the chromosome (cps gene cluster)...
  36. Bonifait L, Grignon L, Grenier D. Fibrinogen induces biofilm formation by Streptococcus suis and enhances its antibiotic resistance. Appl Environ Microbiol. 2008;74:4969-72 pubmed publisher
    In this study, we showed that supplementing the culture medium with fibrinogen induced biofilm formation by Streptococcus suis in a dose-dependent manner. Biofilm-grown S...
  37. Hu Q, Liu P, Yu Z, Zhao G, Li J, Teng L, et al. Identification of a cell wall-associated subtilisin-like serine protease involved in the pathogenesis of Streptococcus suis serotype 2. Microb Pathog. 2010;48:103-9 pubmed publisher
    b>Streptococcus suis is an important swine and human pathogen, and also an emerging zoonotic agent. A surface-associated subtilisin-like serine protease (SspA) of S...
  38. Marois C, Le Devendec L, Gottschalk M, Kobisch M. Detection and molecular typing of Streptococcus suis in tonsils from live pigs in France. Can J Vet Res. 2007;71:14-22 pubmed
    b>Streptococcus suis is an important pathogen of swine, causing meningitis, arthritis, polyserositis, septicemia, and sudden death in weaning piglets as well as fattening pigs...
  39. Vanier G, Segura M, Gottschalk M. Characterization of the invasion of porcine endothelial cells by Streptococcus suis serotype 2. Can J Vet Res. 2007;71:81-9 pubmed
    b>Streptococcus suis serotype 2 is an important swine pathogen associated mainly with meningitis. In a previous study, we demonstrated the ability of S...
  40. Fittipaldi N, Sekizaki T, Takamatsu D, Harel J, Dominguez Punaro M, von Aulock S, et al. D-alanylation of lipoteichoic acid contributes to the virulence of Streptococcus suis. Infect Immun. 2008;76:3587-94 pubmed publisher
    We generated by allelic replacement a DeltadltA mutant of a virulent Streptococcus suis serotype 2 field strain and evaluated the contribution of lipoteichoic acid (LTA) d-alanylation to the virulence traits of this swine pathogen and ..
  41. Kerdsin A, Dejsirilert S, Akeda Y, Sekizaki T, Hamada S, Gottschalk M, et al. Fifteen Streptococcus suis serotypes identified by multiplex PCR. J Med Microbiol. 2012;61:1669-72 pubmed publisher
    A multiplex PCR was developed to detect 15 serotypes of Streptococcus suis. This multiplex PCR was separated into two reaction sets...
  42. Chang B, Wada A, Ikebe T, Ohnishi M, Mita K, Endo M, et al. Characteristics of Streptococcus suis isolated from patients in Japan. Jpn J Infect Dis. 2006;59:397-9 pubmed
    Seven cases of Streptococcus suis infection in Japan during 1994 and 2006 were summarized. All cases had porcine exposure and five of them had hand skin injury during the exposure...
  43. Fittipaldi N, Gottschalk M, Vanier G, Daigle F, Harel J. Use of selective capture of transcribed sequences to identify genes preferentially expressed by Streptococcus suis upon interaction with porcine brain microvascular endothelial cells. Appl Environ Microbiol. 2007;73:4359-64 pubmed
    ..approach, we identified 28 genes preferentially expressed by the major swine pathogen and zoonotic agent Streptococcus suis upon interaction with porcine brain microvascular endothelial cells...
  44. Takamatsu D, Wongsawan K, Osaki M, Nishino H, Ishiji T, Tharavichitkul P, et al. Streptococcus suis in humans, Thailand. Emerg Infect Dis. 2008;14:181-3 pubmed publisher
  45. Rodríguez Ortega M, Luque I, Tarradas C, Bárcena J. Overcoming function annotation errors in the Gram-positive pathogen Streptococcus suis by a proteomics-driven approach. BMC Genomics. 2008;9:588 pubmed publisher
    ..The identified proteins are contrasted by computational analysis and their sequences are inspected to correct possible errors in function prediction...
  46. Pan X, Ge J, Li M, Wu B, Wang C, Wang J, et al. The orphan response regulator CovR: a globally negative modulator of virulence in Streptococcus suis serotype 2. J Bacteriol. 2009;191:2601-12 pubmed publisher
    b>Streptococcus suis serotype 2 is an emerging zoonotic pathogen responsible for a wide range of life-threatening diseases in pigs and humans. However, the pathogenesis of S. suis serotype 2 infection is not well understood...
  47. Holden M, Hauser H, Sanders M, Ngo T, Cherevach I, Cronin A, et al. Rapid evolution of virulence and drug resistance in the emerging zoonotic pathogen Streptococcus suis. PLoS ONE. 2009;4:e6072 pubmed publisher
    b>Streptococcus suis is a zoonotic pathogen that infects pigs and can occasionally cause serious infections in humans. S...
  48. Fittipaldi N, Xu J, Lacouture S, Tharavichitkul P, Osaki M, Sekizaki T, et al. Lineage and virulence of Streptococcus suis serotype 2 isolates from North America. Emerg Infect Dis. 2011;17:2239-44 pubmed publisher
    We performed multilocus sequence typing of 64 North American Streptococcus suis serotype 2 porcine isolates. Strains were sequence type (ST) 28 (51%), ST25 (44%), and ST1 (5%)...
  49. Poggenborg R, Gaïni S, Kjaeldgaard P, Christensen J. Streptococcus suis: meningitis, spondylodiscitis and bacteraemia with a serotype 14 strain. Scand J Infect Dis. 2008;40:346-9 pubmed publisher
    Meningitis and spondylodiscitis caused by Streptococcus suis is a rare disease which is contracted by occupational exposure to pigs. We report a 54-y-old pig-farm worker with S...
  50. Wu Z, Zhang W, Lu C. Comparative proteome analysis of secreted proteins of Streptococcus suis serotype 9 isolates from diseased and healthy pigs. Microb Pathog. 2008;45:159-66 pubmed publisher
    b>Streptococcus suis is an important swine pathogen responsible for a variety of human diseases. Investigations of virulence factors have focused on S. suis serotype 2 strains (SS2), which are the most invasive isolates worldwide...
  51. Navacharoen N, Chantharochavong V, Hanprasertpong C, Kangsanarak J, Lekagul S. Hearing and vestibular loss in Streptococcus suis infection from swine and traditional raw pork exposure in northern Thailand. J Laryngol Otol. 2009;123:857-62 pubmed publisher
    To describe a series of 40 culture-proven, Streptococcus suis infected patients, focusing on route of entry and on hearing and vestibular dysfunction.
  52. Feng Y, Shi X, Zhang H, Zhang S, Ma Y, Zheng B, et al. Recurrence of human Streptococcus suis infections in 2007: three cases of meningitis and implications that heterogeneous S. suis 2 circulates in China. Zoonoses Public Health. 2009;56:506-14 pubmed publisher
    Emergence of fatal Streptococcus suis serotype 2 (S. suis 2, SS2) in China, 2005, has greatly challenged the public health, raising serious concerns about its global circulation...
  53. Feng Y, Zhang H, Ma Y, Gao G. Uncovering newly emerging variants of Streptococcus suis, an important zoonotic agent. Trends Microbiol. 2010;18:124-31 pubmed publisher
    b>Streptococcus suis is recognized as a major swine pathogen and an emerging zoonotic agent. Two large-scale outbreaks of severe S...
  54. Ferrando M, Fuentes S, De Greeff A, Smith H, Wells J. ApuA, a multifunctional alpha-glucan-degrading enzyme of Streptococcus suis, mediates adhesion to porcine epithelium and mucus. Microbiology. 2010;156:2818-28 pubmed publisher
    We have identified apuA in Streptococcus suis, which encodes a bifunctional amylopullulanase with conserved alpha-amylase and pullulanase substrate-binding domains and catalytic motifs...
  55. Mandanici F, Gómez Gascón L, Garibaldi M, Olaya Abril A, Luque I, Tarradas C, et al. A surface protein of Streptococcus suis serotype 2 identified by proteomics protects mice against infection. J Proteomics. 2010;73:2365-9 pubmed publisher
    b>Streptococcus suis serotype 2 is a major Gram-positive swine pathogen, causing also zoonoses...
  56. Xu M, Wang S, Li L, Lei L, Liu Y, Shi W, et al. Secondary infection with Streptococcus suis serotype 7 increases the virulence of highly pathogenic porcine reproductive and respiratory syndrome virus in pigs. Virol J. 2010;7:184 pubmed publisher
    Porcine reproductive and respiratory syndrome virus (PRRSV) and Streptococcus suis are common pathogens in pigs. In samples collected during the porcine high fever syndrome (PHFS) outbreak in many parts of China, PRRSV and S...
  57. Fulde M, Willenborg J, De Greeff A, Benga L, Smith H, Valentin Weigand P, et al. ArgR is an essential local transcriptional regulator of the arcABC operon in Streptococcus suis and is crucial for biological fitness in an acidic environment. Microbiology. 2011;157:572-82 pubmed publisher
    b>Streptococcus suis is one of the most important pathogens in pigs and can also cause severe infections in humans. Despite its clinical relevance, very little is known about the factors that contribute to its virulence...
  58. Wang Y, Zhang W, Wu Z, Lu C. Reduced virulence is an important characteristic of biofilm infection of Streptococcus suis. FEMS Microbiol Lett. 2011;316:36-43 pubmed publisher
    b>Streptococcus suis 2 (SS2) is a zoonotic pathogen that can participate in biofilm formation to survive in hostile environments...
  59. Li M, Shen X, Yan J, Han H, Zheng B, Liu D, et al. GI-type T4SS-mediated horizontal transfer of the 89K pathogenicity island in epidemic Streptococcus suis serotype 2. Mol Microbiol. 2011;79:1670-83 pubmed publisher
    ..89K is a newly identified PAI in epidemic Streptococcus suis isolates that are related to the two recent large-scale outbreaks of human infection in China...
  60. Schwerk C, Papandreou T, Schuhmann D, Nickol L, Borkowski J, Steinmann U, et al. Polar invasion and translocation of Neisseria meningitidis and Streptococcus suis in a novel human model of the blood-cerebrospinal fluid barrier. PLoS ONE. 2012;7:e30069 pubmed publisher
    ..Importantly, when challenged with the zoonotic pathogen Streptococcus suis or the human pathogenic bacterium Neisseria meningitidis the HIBCPP show polar bacterial invasion only from ..
  61. Han H, Liu C, Wang Q, Xuan C, Zheng B, Tang J, et al. The two-component system Ihk/Irr contributes to the virulence of Streptococcus suis serotype 2 strain 05ZYH33 through alteration of the bacterial cell metabolism. Microbiology. 2012;158:1852-66 pubmed publisher
    b>Streptococcus suis serotype 2 (S. suis 2) is an important zoonotic pathogen. It causes heavy economic losses in the pig-farming industry and can be associated with severe infections in humans, e.g. streptococcal toxic shock syndrome...
  62. Pian Y, Gan S, Wang S, Guo J, Wang P, Zheng Y, et al. Fhb, a novel factor H-binding surface protein, contributes to the antiphagocytic ability and virulence of Streptococcus suis. Infect Immun. 2012;80:2402-13 pubmed publisher
    b>Streptococcus suis serotype 2 is a Gram-positive bacterium that causes sepsis and meningitis in piglets and humans. The mechanisms of S. suis serotype 2 invasive disease are not well understood...
  63. Varela N, Gadbois P, Thibault C, Gottschalk M, Dick P, Wilson J. Antimicrobial resistance and prudent drug use for Streptococcus suis. Anim Health Res Rev. 2013;14:68-77 pubmed publisher
    ..resistance patterns and prudent use of antimicrobials to reduce the impact and spread of resistant Streptococcus suis strains. S. suis is an important pathogen in swine, which can cause significant economic loss...
  64. Pallares F, Schmitt C, Roth J, Evans R, Kinyon J, Halbur P. Evaluation of a ceftiofur-washed whole cell Streptococcus suis bacterin in pigs. Can J Vet Res. 2004;68:236-40 pubmed
    The efficacy of currently available washed whole cell Streptococcus suis bacterins is generally poor. We developed and tested the efficacy of a novel ceftiofur-washed whole cell bacterin...
  65. Su Y, Yao W, Perez Gutierrez O, Smidt H, Zhu W. Changes in abundance of Lactobacillus spp. and Streptococcus suis in the stomach, jejunum and ileum of piglets after weaning. FEMS Microbiol Ecol. 2008;66:546-55 pubmed publisher
    ..and Streptococcus suis populations as potentially beneficial and harmful groups, in the stomach, jejunum and ileum of piglets after ..
  66. Liu L, Cheng G, Wang C, Pan X, Cong Y, Pan Q, et al. Identification and experimental verification of protective antigens against Streptococcus suis serotype 2 based on genome sequence analysis. Curr Microbiol. 2009;58:11-7 pubmed publisher
    b>Streptococcus suis serotype 2 (S. suis 2) is an important zoonotic pathogen that can cause severe disease and even death in both humans and swine. No effective vaccine is clinically available...
  67. Zhang A, Chen B, Li R, Mu X, Han L, Zhou H, et al. Identification of a surface protective antigen, HP0197 of Streptococcus suis serotype 2. Vaccine. 2009;27:5209-13 pubmed publisher
    b>Streptococcus suis serotype 2 (SS2) is a porcine and human pathogen with adhesive and invasive properties...
  68. Zhang A, Mu X, Chen B, Liu C, Han L, Chen H, et al. Identification and characterization of IgA1 protease from Streptococcus suis. Vet Microbiol. 2010;140:171-5 pubmed publisher
    b>Streptococcus suis (S. suis) is a major swine pathogen and an emerging zoonotic agent. However, the current understanding of the S. suis pathogenesis of infection remains limited. In the present study, an IgA1 protease of S...
  69. Ju Y, Hao H, Xiong G, Geng H, Zheng Y, Wang J, et al. Development of colloidal gold-based immunochromatographic assay for rapid detection of Streptococcus suis serotype 2. Vet Immunol Immunopathol. 2010;133:207-11 pubmed publisher
    To develop colloidal gold immunochromatographic strips for the direct detection of the Streptococcus suis serotype 2 antigen, colloidal gold was prepared by reduction of a gold salt with sodium citrate and coupled with polyclonal antibody ..
  70. Aranda J, Cortés P, Garrido M, Fittipaldi N, Llagostera M, Gottschalk M, et al. Contribution of the FeoB transporter to Streptococcus suis virulence. Int Microbiol. 2009;12:137-43 pubmed
    ..In this work, we show that the swine pathogen and zoonotic agent Streptococcus suis has a feoAB operon similar to that encoding an iron transporter system in Escherichia coli...
  71. Tanabe S, Bonifait L, Fittipaldi N, Grignon L, Gottschalk M, Grenier D. Pleiotropic effects of polysaccharide capsule loss on selected biological properties of Streptococcus suis. Can J Vet Res. 2010;74:65-70 pubmed
    In this study, an unencapsulated Streptococcus suis mutant was used to investigate the pleiotropic effects resulting from capsule loss. The capsule deficient mutant of S...
  72. Li J, Tan C, Zhou Y, Fu S, Hu L, Hu J, et al. The two-component regulatory system CiaRH contributes to the virulence of Streptococcus suis 2. Vet Microbiol. 2011;148:99-104 pubmed publisher
    ..7 macrophage against Streptococcus suis 2, but also increased blood clearance of S. suis 2 in vivo...
  73. Lv Q, Hao H, Bi L, Zheng Y, Jiang Y, Lv S. [Purification and biological activities analysis of streptococcus suis Serotype 2 suilysin]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2011;27:374-6 pubmed
    ..To explore the purification methods of wild-type and recombinant suilysin and to evaluate their biological activities...
  74. Wichgers Schreur P, Rebel J, Smits M, van Putten J, Smith H. TroA of Streptococcus suis is required for manganese acquisition and full virulence. J Bacteriol. 2011;193:5073-80 pubmed publisher
    b>Streptococcus suis causes infections in pigs and occasionally in humans, resulting in manifestations as meningitis, sepsis, arthritis, and septic shock. For survival within the host, S...
  75. Benga L, Goethe R, Rohde M, Valentin Weigand P. Non-encapsulated strains reveal novel insights in invasion and survival of Streptococcus suis in epithelial cells. Cell Microbiol. 2004;6:867-81 pubmed
    b>Streptococcus suis is a porcine and human pathogen causing invasive diseases, such as meningitis or septicaemia. Host cell interactions of S...
  76. Sekizaki T, Takamatsu D, Osaki M, Shimoji Y. Different foreign genes incidentally integrated into the same locus of the Streptococcus suis genome. J Bacteriol. 2005;187:872-83 pubmed
    Some strains of Streptococcus suis possess a type II restriction-modification (RM) system, whose genes are thought to be inserted into the genome between purH and purD from a foreign source by illegitimate recombination...
  77. Wilson S, Norton P, Haverson K, Leigh J, Bailey M. Interactions between Streptococcus suis serotype 2 and cells of the myeloid lineage in the palatine tonsil of the pig. Vet Immunol Immunopathol. 2007;117:116-23 pubmed
    b>Streptococcus suis is a major pathogen in pigs and causes significant morbidity and mortality in herds world-wide. A major problem with S...
  78. Vanier G, Sekizaki T, Domínguez Punaro M, Esgleas M, Osaki M, Takamatsu D, et al. Disruption of srtA gene in Streptococcus suis results in decreased interactions with endothelial cells and extracellular matrix proteins. Vet Microbiol. 2008;127:417-24 pubmed
    b>Streptococcus suis, a major pathogen of swine, is an emerging zoonotic agent which causes meningitis and septic shock. In this study, we investigated the ability of S...
  79. Wang K, Lu C. Streptococcus suis type 2 culture supernatant enhances the infection ability of the Swine influenza virus H3 subtype in MDCK cells. Berl Munch Tierarztl Wochenschr. 2008;121:198-202 pubmed
    Swine Influenza virus and Streptococcus suis type 2 often occur as a clinical coinfection in pigs, the syndrome of which is more serious than the virus or bacterium sole infection...
  80. Nghia H, Ho D, Tu L, Le T, Wolbers M, Thai C, et al. Risk factors of Streptococcus suis infection in Vietnam. A case-control study. PLoS ONE. 2011;6:e17604 pubmed publisher
    b>Streptococcus suis infection, an emerging zoonosis, is an increasing public health problem across South East Asia and the most common cause of acute bacterial meningitis in adults in Vietnam...
  81. Schultsz C, Jansen E, Keijzers W, Rothkamp A, Duim B, Wagenaar J, et al. Differences in the population structure of invasive Streptococcus suis strains isolated from pigs and from humans in The Netherlands. PLoS ONE. 2012;7:e33854 pubmed publisher
    b>Streptococcus suis serotype 2 is the main cause of zoonotic S. suis infection despite the fact that other serotypes are frequently isolated from diseased pigs...
  82. Feng Y, Cao M, Shi J, Zhang H, Hu D, Zhu J, et al. Attenuation of Streptococcus suis virulence by the alteration of bacterial surface architecture. Sci Rep. 2012;2:710 pubmed publisher
    ..Here we report a functional NeuB homologue of Streptococcus suis, a zoonotic agent, and systematically address its molecular and immunological role in bacterial virulence...
  83. Gruening P, Fulde M, Valentin Weigand P, Goethe R. Structure, regulation, and putative function of the arginine deiminase system of Streptococcus suis. J Bacteriol. 2006;188:361-9 pubmed
    b>Streptococcus suis is an important cause of infectious diseases in young pigs. Little is known about the virulence factors or protective antigens of S. suis...
  84. Lun Z, Wang Q, Chen X, Li A, Zhu X. Streptococcus suis: an emerging zoonotic pathogen. Lancet Infect Dis. 2007;7:201-9 pubmed
    b>Streptococcus suis is a major porcine pathogen worldwide, and can be transmitted to human beings by close contact with sick or carrier pigs...
  85. Si Y, Yuan F, Chang H, Liu X, Li H, Cai K, et al. Contribution of glutamine synthetase to the virulence of Streptococcus suis serotype 2. Vet Microbiol. 2009;139:80-8 pubmed publisher
    b>Streptococcus suis serotype 2 (S. suis 2) is an important pathogen, responsible for diverse diseases in swine and human. In this study, we investigated the role of the glutamine synthetase (GlnA) in the pathogenesis of S. suis 2 in mice...
  86. Chander Y, Oliveira S, Goyal S. Identification of the tet(B) resistance gene in Streptococcus suis. Vet J. 2011;189:359-60 pubmed publisher
    ..In this study tet(B) was detected in plasmid extracts from 17/111 (15%) Streptococcus suis isolates from diseased pigs, representing the first report of this resistance gene in gram positive bacteria.
  87. Ngo T, Tran T, Tran T, Nguyen V, Campbell J, Pham H, et al. Slaughterhouse pigs are a major reservoir of Streptococcus suis serotype 2 capable of causing human infection in southern Vietnam. PLoS ONE. 2011;6:e17943 pubmed publisher
    b>Streptococcus suis is a pathogen of major economic significance to the swine industry and is increasingly recognized as an emerging zoonotic agent in Asia. In Vietnam, S. suis is the leading cause of bacterial meningitis in adult humans...
  88. Gottschalk M, Lacouture S, Bonifait L, Roy D, Fittipaldi N, Grenier D. Characterization of Streptococcus suis isolates recovered between 2008 and 2011 from diseased pigs in Québec, Canada. Vet Microbiol. 2013;162:819-25 pubmed publisher
    In the present study we report the distribution of different serotypes of Streptococcus suis among strains isolated from diseased pigs in Québec, Canada, recovered between 2008 and 2011...
  89. Esgleas M, Lacouture S, Gottschalk M. Streptococcus suis serotype 2 binding to extracellular matrix proteins. FEMS Microbiol Lett. 2005;244:33-40 pubmed
    b>Streptococcus suis serotype 2 is a major swine and human pathogen that causes septicemia and meningitis. The ability of S. suis serotype 2 to bind to different extracellular matrix (ECM) proteins was evaluated by ELISA...
  90. Normile D. Infectious diseases. WHO probes deadliness of China's pig-borne disease. Science. 2005;309:1308-9 pubmed
  91. Zhang C, Ning Y, Zhang Z, Song L, Qiu H, Gao H. In vitro antimicrobial susceptibility of Streptococcus suis strains isolated from clinically healthy sows in China. Vet Microbiol. 2008;131:386-92 pubmed publisher
    b>Streptococcus suis is an important pathogen in the swine industry...
  92. Manzin A, Palmieri C, Serra C, Saddi B, Princivalli M, Loi G, et al. Streptococcus suis meningitis without history of animal contact, Italy. Emerg Infect Dis. 2008;14:1946-8 pubmed publisher