pasteurella multocida

Summary

Summary: A species of gram-negative, facultatively anaerobic, rod-shaped bacteria normally found in the flora of the mouth and respiratory tract of animals and birds. It causes shipping fever (see PASTEURELLOSIS, PNEUMONIC); HEMORRHAGIC BACTEREMIA; and intestinal disease in animals. In humans, disease usually arises from a wound infection following a bite or scratch from domesticated animals.

Top Publications

  1. Kobayaa H, Souki R, Trust S, Domachowske J. Pasteurella multocida meningitis in newborns after incidental animal exposure. Pediatr Infect Dis J. 2009;28:928-9 pubmed publisher
    We present briefly 2 newborns with Pasteurella multocida meningitis following incidental household exposure to domestic pets and review 36 additional cases from the literature. Of 38 reported cases of P...
  2. Freshwater A. Why your housecat's trite little bite could cause you quite a fright: a study of domestic felines on the occurrence and antibiotic susceptibility of Pasteurella multocida. Zoonoses Public Health. 2008;55:507-13 pubmed publisher
    ..b>Pasteurella multocida is the most commonly cultured bacterium from infected cat bite wounds...
  3. Hildebrand D, Heeg K, Kubatzky K. Pasteurella multocida toxin-stimulated osteoclast differentiation is B cell dependent. Infect Immun. 2011;79:220-8 pubmed publisher
    b>Pasteurella multocida is a Gram-negative bacillus that infects a number of wild and domestic animals, causing respiratory diseases...
  4. Steen J, Steen J, Harrison P, Seemann T, Wilkie I, Harper M, et al. Fis is essential for capsule production in Pasteurella multocida and regulates expression of other important virulence factors. PLoS Pathog. 2010;6:e1000750 pubmed publisher
    ..multocida and identify Fis as a critical regulator of capsule expression. Furthermore, Fis is involved in the regulation of a range of other P. multocida genes including important virulence factors. ..
  5. Aminova L, Wilson B. Calcineurin-independent inhibition of 3T3-L1 adipogenesis by Pasteurella multocida toxin: suppression of Notch1, stabilization of beta-catenin and pre-adipocyte factor 1. Cell Microbiol. 2007;9:2485-96 pubmed
    b>Pasteurella multocida toxin (PMT) is a potent mitogen and a specific activator of Gq-dependent signalling pathways. PMT impairs osteoblast differentiation and causes bone loss and fat reduction in vivo...
  6. Griffin D, Chengappa M, Kuszak J, McVey D. Bacterial pathogens of the bovine respiratory disease complex. Vet Clin North Am Food Anim Pract. 2010;26:381-94 pubmed publisher
    ..There are other important bacterial pathogens of BRD, such as Pasteurella multocida, Histophulus somni, and Mycoplasma bovis. Mixed infections with these organisms do occur...
  7. Bethe A, Wieler L, Selbitz H, Ewers C. Genetic diversity of porcine Pasteurella multocida strains from the respiratory tract of healthy and diseased swine. Vet Microbiol. 2009;139:97-105 pubmed publisher
    A total of 382 porcine Pasteurella multocida strains, isolated from cases of pneumonia and progressive atrophic rhinitis (PAR) as well as from clinically healthy pigs of more than 150 German husbandries were characterized by detection of ..
  8. Confer A. Update on bacterial pathogenesis in BRD. Anim Health Res Rev. 2009;10:145-8 pubmed publisher
    Mannheimia haemolytica, Pasteurella multocida, Histophilus somni, Mycoplasma bovis and Arcanobacterium pyogenes are all frequently implicated in bovine respiratory disease (BRD). M...
  9. Siegert P, Schmidt G, Papatheodorou P, Wieland T, Aktories K, Orth J. Pasteurella multocida toxin prevents osteoblast differentiation by transactivation of the MAP-kinase cascade via the G?(q/11)--p63RhoGEF--RhoA axis. PLoS Pathog. 2013;9:e1003385 pubmed publisher
    The 146-kDa Pasteurella multocida toxin (PMT) is the main virulence factor to induce P. multocida-associated progressive atrophic rhinitis in various animals...

More Information

Publications92

  1. Wu J, Shien J, Shieh H, Chen C, Chang P. Protective immunity conferred by recombinant Pasteurella multocida lipoprotein E (PlpE). Vaccine. 2007;25:4140-8 pubmed
    The genes encoding Pasteurella multocida lipoprotein E (PlpE) and lipoprotein B (PlpB) were cloned from P. multocida strain X-73 (serotype A:1) and expressed in Escherichia coli...
  2. Chavaroche A, Springer J, Kooy F, Boeriu C, Eggink G. In vitro synthesis of heparosan using recombinant Pasteurella multocida heparosan synthase PmHS2. Appl Microbiol Biotechnol. 2010;85:1881-91 pubmed publisher
    ..As heparin-like molecules represent a great interest in the pharmaceutical area, the cryptic Pasteurella multocida heparosan synthase PmHS2 found to catalyze heparosan synthesis using substrate analogs has been studied...
  3. Hansen M, Pors S, Jensen H, Bille Hansen V, Bisgaard M, Flachs E, et al. An investigation of the pathology and pathogens associated with porcine respiratory disease complex in Denmark. J Comp Pathol. 2010;143:120-31 pubmed publisher
    ..were detected in different combinations. PCV2, M. hyopneumoniae, M. hyorhinis and Pasteurella multocida were detected most frequently among the PRDC affected swine and the diversity and number of pathogens were ..
  4. Sjolund M, Zoric M, Persson M, Karlsson G, Wallgren P. Disease patterns and immune responses in the offspring to sows with high or low antibody levels to Actinobacillus pleuropneumoniae serotype 2. Res Vet Sci. 2011;91:25-31 pubmed publisher
    The serum antibody responses to Actinobacillus pleuropneumoniae and the secondary invader Pasteurella multocida were monitored from birth until slaughter in the offspring to sows with high or low levels of serum antibodies to A...
  5. Chavaroche A, van den Broek L, Springer J, Boeriu C, Eggink G. Analysis of the polymerization initiation and activity of Pasteurella multocida heparosan synthase PmHS2, an enzyme with glycosyltransferase and UDP-sugar hydrolase activity. J Biol Chem. 2011;286:1777-85 pubmed publisher
    ..Details on the heparosan chain initiation by Pasteurella multocida heparosan synthase PmHS2 and its influence on the polymerization process have not been reported yet...
  6. Orth J, Aktories K, Kubatzky K. Modulation of host cell gene expression through activation of STAT transcription factors by Pasteurella multocida toxin. J Biol Chem. 2007;282:3050-7 pubmed
    The Pasteurella multocida toxin (PMT) is highly mitogenic and has potential carcinogenic properties...
  7. Atashpaz S, Shayegh J, Hejazi M. Rapid virulence typing of Pasteurella multocida by multiplex PCR. Res Vet Sci. 2009;87:355-7 pubmed publisher
    The gram-negative bacterium Pasteurella multocida constitutes a heterogeneous species associated with wide range of disease in many animals. Isolates are classified into five groups based on capsular antigen (capA, B, D, E and F)...
  8. Hatfaludi T, Al Hasani K, Gong L, Boyce J, Ford M, Wilkie I, et al. Screening of 71 P. multocida proteins for protective efficacy in a fowl cholera infection model and characterization of the protective antigen PlpE. PLoS ONE. 2012;7:e39973 pubmed publisher
    ..However, PlpE is not an essential virulence factor. This is the first report of a denatured recombinant protein stimulating protection against fowl cholera. ..
  9. Campoy S, Aranda J, Alvarez G, Barbe J, Llagostera M. Isolation and sequencing of a temperate transducing phage for Pasteurella multocida. Appl Environ Microbiol. 2006;72:3154-60 pubmed
    A temperate bacteriophage (F108) has been isolated through mitomycin C induction of a Pasteurella multocida serogroup A strain...
  10. Harper M, St Michael F, John M, Vinogradov E, Adler B, Boyce J, et al. Pasteurella multocida Heddleston serovars 1 and 14 express different lipopolysaccharide structures but share the same lipopolysaccharide biosynthesis outer core locus. Vet Microbiol. 2011;150:289-96 pubmed publisher
    b>Pasteurella multocida strains are classified using the Heddleston lipopolysaccharide (LPS) serotyping scheme into 16 serovars...
  11. Hatfaludi T, Al Hasani K, Boyce J, Adler B. Outer membrane proteins of Pasteurella multocida. Vet Microbiol. 2010;144:1-17 pubmed publisher
    b>Pasteurella multocida is a ubiquitous pathogen which causes a range of diseases in diverse animal species...
  12. Katsuda K, Hoshinoo K, Ueno Y, Kohmoto M, Mikami O. Virulence genes and antimicrobial susceptibility in Pasteurella multocida isolates from calves. Vet Microbiol. 2013;167:737-41 pubmed publisher
    A total of 378 isolates of Pasteurella multocida from clinically healthy and diseased calves were characterised for their susceptibility to 9 antimicrobial agents and screened by PCR for the presence of antimicrobial resistance genes and ..
  13. Tatum F, Tabatabai L, Briggs R. Cross-protection against fowl cholera disease with the use of recombinant Pasteurella multocida FHAB2 peptides vaccine. Avian Dis. 2012;56:589-91 pubmed
    It has been demonstrated that fhaB2 (filamentous hemagglutinin) is an important virulence factor for Pasteurella multocida in development of fowl cholera disease and that vaccination with recombinant FHAB2 peptides derived from P...
  14. Dabo S, Taylor J, Confer A. Pasteurella multocida and bovine respiratory disease. Anim Health Res Rev. 2007;8:129-50 pubmed publisher
    b>Pasteurella multocida is a pathogenic Gram-negative bacterium that has been classified into three subspecies, five capsular serogroups and 16 serotypes. P...
  15. Harper M, Boyce J, Cox A, St Michael F, Wilkie I, Blackall P, et al. Pasteurella multocida expresses two lipopolysaccharide glycoforms simultaneously, but only a single form is required for virulence: identification of two acceptor-specific heptosyl I transferases. Infect Immun. 2007;75:3885-93 pubmed
    Lipopolysaccharide (LPS) is a critical virulence determinant in Pasteurella multocida and a major antigen responsible for host protective immunity...
  16. Harper M, Cox A, Adler B, Boyce J. Pasteurella multocida lipopolysaccharide: the long and the short of it. Vet Microbiol. 2011;153:109-15 pubmed publisher
    b>Pasteurella multocida is a capsulated, gram-negative cocco-bacillus that can cause serious disease in a wide range of mammals and birds. P. multocida strains are classified into 16 serovars based on lipopolysaccharide (LPS) antigens...
  17. Boyce J, Adler B. How does Pasteurella multocida respond to the host environment?. Curr Opin Microbiol. 2006;9:117-22 pubmed
    b>Pasteurella multocida is a Gram-negative bacterial pathogen, which causes diseases of economic importance in a wide range of animal species. The response of P...
  18. Stahel A, Hoop R, Kuhnert P, Korczak B. Phenotypic and genetic characterization of Pasteurella multocida and related isolates from rabbits in Switzerland. J Vet Diagn Invest. 2009;21:793-802 pubmed
    Several bacteria belonging to the family Pasteurellaceae are potential pathogens in rabbits. In particular, Pasteurella multocida is considered to be important, and outbreaks caused by this species result in considerable economic losses ..
  19. Shivachandra S, Kumar A, Yogisharadhya R, Ramakrishnan M, Viswas K. Carboxyl terminus heterogeneity of type IV fimbrial subunit protein of Pasteurella multocida isolates. Vet Res Commun. 2013;37:269-75 pubmed publisher
    b>Pasteurella multocida, a Gram-negative bacterial pathogen, known to affect a wide range of domestic as well as wild animal and avian species throughout the world by causing either systemic or localized infections termed as '..
  20. Tang X, Zhao Z, Hu J, Wu B, Cai X, He Q, et al. Isolation, antimicrobial resistance, and virulence genes of Pasteurella multocida strains from swine in China. J Clin Microbiol. 2009;47:951-8 pubmed publisher
    A total of 233 isolates of Pasteurella multocida were obtained from 2,912 cases of clinical respiratory disease in pigs in China, giving an isolation rate of 8.0%. Serogroup A P. multocida isolates were isolated from 92 cases (39...
  21. Leotta G, Chinen I, Vigo G, Pecoraro M, Rivas M. Outbreaks of avian cholera in Hope Bay, Antarctica. J Wildl Dis. 2006;42:259-70 pubmed
    ..b>Pasteurella multocida isolates were identified by biochemical tests, capsular type, somatic serotype, and susceptibility to nine ..
  22. Köndgen S, Leider M, Lankester F, Bethe A, Lübke Becker A, Leendertz F, et al. Pasteurella multocida involved in respiratory disease of wild chimpanzees. PLoS ONE. 2011;6:e24236 pubmed publisher
    b>Pasteurella multocida can cause a variety of diseases in various species of mammals and birds throughout the world but nothing is known about its importance for wild great apes. In this study we isolated P...
  23. Hildebrand D, Walker P, Dalpke A, Heeg K, Kubatzky K. Pasteurella multocida Toxin-induced Pim-1 expression disrupts suppressor of cytokine signalling (SOCS)-1 activity. Cell Microbiol. 2010;12:1732-45 pubmed publisher
    b>Pasteurella multocida Toxin (PMT) is a mitogenic protein toxin that manipulates signal transduction cascades of mammalian host cells and upregulates Janus kinase (JAK) and signal transducers of transcription (STAT) activity...
  24. Sellyei B, Varga Z, Szentesi Samu K, Kaszanyitzky E, Magyar T. Antimicrobial susceptibility of Pasteurella multocida isolated from swine and poultry. Acta Vet Hung. 2009;57:357-67 pubmed publisher
    b>Pasteurella multocida causes infectious diseases in a wide range of animal species. Antimicrobial therapy is still an effective tool for treatment. Generally, P...
  25. Praveena P, Periasamy S, Kumar A, Singh N. Cytokine profiles, apoptosis and pathology of experimental Pasteurella multocida serotype A1 infection in mice. Res Vet Sci. 2010;89:332-9 pubmed publisher
    Mice were experimentally infected with Pasteurella multocida serotype A1 to study the cytokine profiles, host cell apoptosis and sequential pathology at different hours of post-infection. Infected mice were dull, anorectic and depressed...
  26. Boyce J, Harper M, St Michael F, John M, Aubry A, Parnas H, et al. Identification of novel glycosyltransferases required for assembly of the Pasteurella multocida A:1 lipopolysaccharide and their involvement in virulence. Infect Immun. 2009;77:1532-42 pubmed publisher
    We previously determined the structure of the Pasteurella multocida Heddleston type 1 lipopolysaccharide (LPS) molecule and characterized some of the transferases essential for LPS biosynthesis. We also showed that P...
  27. Simonen Jokinen T, Eskelinen U, Härtel H, Nikunen S, Saloniemi H, Maisi P. Gelatinolytic matrix metalloproteinases-2 and -9 in tracheobronchial lavage fluid obtained from calves with concurrent infections of Pasteurella multocida and Mycoplasma bovirhinis. Am J Vet Res. 2005;66:2101-6 pubmed
    To study gelatinolytic matrix metalloproteinases (MMPs) in tracheobronchial lavage fluid (TBLF) obtained from clinically normal calves and calves with Pasteurella multocida infection.
  28. Blöcker D, Berod L, Fluhr J, Orth J, Idzko M, Aktories K, et al. Pasteurella multocida toxin (PMT) activates RhoGTPases, induces actin polymerization and inhibits migration of human dendritic cells, but does not influence macropinocytosis. Int Immunol. 2006;18:459-64 pubmed
    ..Here we characterized the influence of Pasteurella multocida toxin (PMT) on monocyte-derived DCs...
  29. Per H, Kumandas S, Gumus H, Ozturk M, Coskun A. Meningitis and subgaleal, subdural, epidural empyema due to Pasteurella multocida. J Emerg Med. 2010;39:35-8 pubmed publisher
    ..b>Pasteurella multocida has been known to cause infections in humans, the most familiar being soft tissue infection after animal ..
  30. Krupa J, Shaya D, Chi L, Linhardt R, Cygler M, Withers S, et al. Quantitative continuous assay for hyaluronan synthase. Anal Biochem. 2007;361:218-25 pubmed
    ..quantitate the glucuronic acid and N-acetylglucosamine transferase activities of hyaluronan synthase from Pasteurella multocida (PmHAS)...
  31. Liu W, Yang M, Xu Z, Zheng H, Liang W, Zhou R, et al. Complete genome sequence of Pasteurella multocida HN06, a toxigenic strain of serogroup D. J Bacteriol. 2012;194:3292-3 pubmed publisher
    b>Pasteurella multocida is an important etiological agent that can cause many economically important diseases in a wide range of mammals and birds. Here, we report the complete genome sequence of P...
  32. Yokose N, Dan K. Pasteurella multocida sepsis, due to a scratch from a pet cat, in a post-chemotherapy neutropenic patient with non-Hodgkin lymphoma. Int J Hematol. 2007;85:146-8 pubmed
    ..These cases demonstrate the importance of the prevention of close contact between pet animals and immunocompromised hosts such as post-chemotherapy neutropenic patients...
  33. MacInnes J, Gottschalk M, Lone A, Metcalf D, Ojha S, Rosendal T, et al. Prevalence of Actinobacillus pleuropneumoniae, Actinobacillus suis, Haemophilus parasuis, Pasteurella multocida, and Streptococcus suis in representative Ontario swine herds. Can J Vet Res. 2008;72:242-8 pubmed
    ..In contrast, toxigenic strains of Pasteurella multocida were detected by a P. multocida--enzyme-linked immunosorbant assay (PMT-ELISA) in only one herd...
  34. Nanduri B, Lawrence M, Boyle C, Ramkumar M, Burgess S. Effects of subminimum inhibitory concentrations of antibiotics on the Pasteurella multocida proteome. J Proteome Res. 2006;5:572-80 pubmed
    ..We analyzed the Pasteurella multocida proteome response to sub-MICs of amoxicillin, chlortetracycline, and enrofloxacin using isotope-coded ..
  35. Tan H, Nagoor N, Sekaran S. Cloning, expression and protective capacity of 37 kDa outer membrane protein gene (ompH) of Pasteurella multocida serotype B:2. Trop Biomed. 2010;27:430-41 pubmed
    The major outer membrane protein (OmpH) of 4 local Malaysian strains of Pasteurella multocida serotype B:2 were characterized in comparison to ATCC strains...
  36. Arumugam N, Ajam N, Blackall P, Asiah N, Ramlan M, Maria J, et al. Capsular serotyping of Pasteurella multocida from various animal hosts - a comparison of phenotypic and genotypic methods. Trop Biomed. 2011;28:55-63 pubmed
    One hundred and fourteen strains of Pasteurella multocida were isolated from different domestic animals species (cattle, buffalo, sheep, goat, pig, rabbit, dog, cat), avian species (chicken, duck, turkey) and wild animals (deer, tiger, ..
  37. Dziva F, Muhairwa A, Bisgaard M, Christensen H. Diagnostic and typing options for investigating diseases associated with Pasteurella multocida. Vet Microbiol. 2008;128:1-22 pubmed
    b>Pasteurella multocida is responsible for major animal diseases of economic significance in both developed and developing countries whereas human infections related to this bacterium are infrequent...
  38. Ni L, Chokhawala H, Cao H, Henning R, Ng L, Huang S, et al. Crystal structures of Pasteurella multocida sialyltransferase complexes with acceptor and donor analogues reveal substrate binding sites and catalytic mechanism. Biochemistry. 2007;46:6288-98 pubmed
    ..Binary X-ray crystal structures of a multifunctional Pasteurella multocida sialyltransferase (Delta24PmST1) with a donor analogue CMP-3F(a)Neu5Ac or CMP-3F(e)Neu5Ac were determined ..
  39. Taylor J, Fulton R, Dabo S, Lehenbauer T, Confer A. Comparison of genotypic and phenotypic characterization methods for Pasteurella multocida isolates from fatal cases of bovine respiratory disease. J Vet Diagn Invest. 2010;22:366-75 pubmed
    Bovine respiratory disease (BRD) is the most costly disease of beef cattle in North America. Because Pasteurella multocida is a commensal of the upper respiratory tract, it is generally considered an opportunistic pathogen...
  40. Register K, DeJong K. Analytical verification of a multiplex PCR for identification of Bordetella bronchiseptica and Pasteurella multocida from swine. Vet Microbiol. 2006;117:201-10 pubmed
    Bordetella bronchiseptica and Pasteurella multocida are etiologic agents of progressive atrophic rhinitis (PAR) and bronchopneumonia in swine. Only dermonecrotic toxin-producing strains of P...
  41. Dabo S, Confer A, Montelongo M, York P, Wyckoff J. Vaccination with Pasteurella multocida recombinant OmpA induces strong but non-protective and deleterious Th2-type immune response in mice. Vaccine. 2008;26:4345-51 pubmed publisher
    b>Pasteurella multocida OmpA (PmOmpA) belongs to the major and multifunctional Escherichia coli OmpA family of proteins...
  42. Hatfaludi T, Al Hasani K, Dunstone M, Boyce J, Adler B. Characterization of TolC efflux pump proteins from Pasteurella multocida. Antimicrob Agents Chemother. 2008;52:4166-71 pubmed publisher
    Two TolC homologs, PM0527 and PM1980, were identified for Pasteurella multocida. A pm0527 mutant displayed increased susceptibility to a range of chemicals, including rifampin (512-fold) and acridine orange (128-fold)...
  43. Nanduri B, Shack L, Burgess S, Lawrence M. The transcriptional response of Pasteurella multocida to three classes of antibiotics. BMC Genomics. 2009;10 Suppl 2:S4 pubmed publisher
    b>Pasteurella multocida is a gram-negative bacterial pathogen that has a broad host range. One of the diseases it causes is fowl cholera in poultry. The availability of the genome sequence of avian P...
  44. Schou T, Permin A, Christensen J, Cu H, Juul Madsen H. Mannan-binding lectin (MBL) in two chicken breeds and the correlation with experimental Pasteurella multocida infection. Comp Immunol Microbiol Infect Dis. 2010;33:183-95 pubmed publisher
    ..serum MBL concentration was determined in two chicken breeds, and the association with the specific Pasteurella multocida humoral immune response during an experimental infection was examined...
  45. Kubatzky K. Pasteurella multocida and immune cells. Curr Top Microbiol Immunol. 2012;361:53-72 pubmed publisher
    b>Pasteurella multocida was first discovered by Perroncito in 1878 and named after Louis Pasteur who first isolated and described this Gram-negative bacterium as the cause of fowl disease in 1880. Subsequently, P...
  46. Boyce J, Seemann T, Adler B, Harper M. Pathogenomics of Pasteurella multocida. Curr Top Microbiol Immunol. 2012;361:23-38 pubmed publisher
    ..Interestingly, based on the current data there is no clear correlation between phylogenetic relatedness and host predilection or disease...
  47. Michael G, Kadlec K, Sweeney M, Brzuszkiewicz E, Liesegang H, Daniel R, et al. ICEPmu1, an integrative conjugative element (ICE) of Pasteurella multocida: structure and transfer. J Antimicrob Chemother. 2012;67:91-100 pubmed publisher
    Integrative and conjugative elements (ICEs) have not been detected in Pasteurella multocida. In this study the multiresistance ICEPmu1 from bovine P...
  48. Boyce J, Cullen P, Nguyen V, Wilkie I, Adler B. Analysis of the Pasteurella multocida outer membrane sub-proteome and its response to the in vivo environment of the natural host. Proteomics. 2006;6:870-80 pubmed
    This study describes the identification of outer membrane proteins (OMPs) of the bacterial pathogen Pasteurella multocida and an analysis of how the expression of these proteins changes during infection of the natural host...
  49. Ahir V, Roy A, Jhala M, Bhanderi B, Mathakiya R, Bhatt V, et al. Genome sequence of Pasteurella multocida subsp. gallicida Anand1_poultry. J Bacteriol. 2011;193:5604 pubmed publisher
    We report the finished and annotated genome sequence of Pasteurella multocida gallicida strain Anand1_poultry, which was isolated from the liver of a diseased adult female chicken...
  50. Ferran A, Toutain P, Bousquet Melou A. Impact of early versus later fluoroquinolone treatment on the clinical; microbiological and resistance outcomes in a mouse-lung model of Pasteurella multocida infection. Vet Microbiol. 2011;148:292-7 pubmed publisher
    ..of the targeted pathogen and the selection of resistant bacteria in a mouse lung infection with Pasteurella multocida. In this model, for a given marbofloxacin dose, the clinical and bacteriological outcomes were better, and ..
  51. Silberfein E, Lin P, Bush R, Zhou W, Lumsden A. Aortic endograft infection due to Pasteurella multocida following a rabbit bite. J Vasc Surg. 2006;43:393-5 pubmed
    ..b>Pasteurella multocida, a gram-negative bacterium, is a commonly found organism in the mouth flora of many house pets...
  52. Ataei S, Burchmore R, Christopher Hodgson J, Finucane A, Parton R, Coote J. Identification of immunogenic proteins associated with protection against haemorrhagic septicaemia after vaccination of calves with a live-attenuated aroA derivative of Pasteurella multocida B:2. Res Vet Sci. 2009;87:207-10 pubmed publisher
    b>Pasteurella multocida serotype B:2 is the causative agent of haemorrhagic septicaemia (HS), a fatal disease of cattle and buffaloes...
  53. Gong Q, Qu N, Niu M, Qin C, Cheng M, Sun X, et al. Immune responses and protective efficacy of a novel DNA vaccine encoding outer membrane protein of avian Pasteurella multocida. Vet Immunol Immunopathol. 2013;152:317-24 pubmed publisher
    Avian Pasteurella multocida is a causative agent of fowl cholera. Two proteins OmpH and OmpA are the major immunogenic antigens of avian P...
  54. Harper M, Boyce J, Adler B. The key surface components of Pasteurella multocida: capsule and lipopolysaccharide. Curr Top Microbiol Immunol. 2012;361:39-51 pubmed publisher
    The capsule and lipopolysaccharide (LPS) of Pasteurella multocida constitute the major components of the bacterial cell surface...
  55. Ellison M, Champlin F. Outer membrane permeability for nonpolar antimicrobial agents underlies extreme susceptibility of Pasteurella multocida to the hydrophobic biocide triclosan. Vet Microbiol. 2007;124:310-8 pubmed
    b>Pasteurella multocida exhibits nonspecific susceptibility to nonpolar antimicrobial agents such as triclosan, despite possessing an ultrastructurally typical gram-negative cell envelope...
  56. McFadden A, Christensen H, Fairley R, Hill F, Gill J, Keeling S, et al. Outbreaks of pleuritis and peritonitis in calves associated with Pasteurella multocida capsular type B strain. N Z Vet J. 2011;59:40-5 pubmed publisher
    ..Affected calves were aged 13-18 weeks (Farm I), 6 months (Farm II), and 2-11 weeks (Farm III), and the mortality rate was 22/175 (13%), 5/80 (6%), and 60/900 (7%), respectively...
  57. Orth J, Fester I, Preuss I, Agnoletto L, Wilson B, Aktories K. Activation of Galpha (i) and subsequent uncoupling of receptor-Galpha(i) signaling by Pasteurella multocida toxin. J Biol Chem. 2008;283:23288-94 pubmed publisher
    ..A number of bacterial protein toxins, e.g. cholera toxin, pertussis toxin (PTx), or Pasteurella multocida toxin (PMT), target heterotrimeric G proteins and have been used to stimulate or block specific signaling ..
  58. Williams K, Halkes K, Kamerling J, DeAngelis P. Critical elements of oligosaccharide acceptor substrates for the Pasteurella multocida hyaluronan synthase. J Biol Chem. 2006;281:5391-7 pubmed
    ..The Pasteurella multocida hyaluronan synthase (PmHAS) catalyzes the polymerization of the alternating beta1,3-N-acetylglucosamine-..
  59. Magyar T, Donkó T, Kovacs F. Atrophic rhinitis vaccine composition triggers different serological profiles that do not correlate with protection. Acta Vet Hung. 2008;56:27-40 pubmed publisher
    ..AR) is a widespread and economically important disease of swine caused by Bordetella bronchiseptica and Pasteurella multocida. It can be controlled by vaccination...
  60. Portis E, Lindeman C, Johansen L, Stoltman G. A ten-year (2000-2009) study of antimicrobial susceptibility of bacteria that cause bovine respiratory disease complex--Mannheimia haemolytica, Pasteurella multocida, and Histophilus somni--in the United States and Canada. J Vet Diagn Invest. 2012;24:932-44 pubmed publisher
    Bovine isolates of Mannheimia haemolytica, Pasteurella multocida, and Histophilus somni, collected from 2000 to 2009, were tested for in vitro susceptibility to ceftiofur, penicillin, danofloxacin, enrofloxacin, florfenicol, tetracycline,..
  61. Singh A, Singh S, Ranjan R, Gupta S, Singh V, Sharma B. Molecular heterogeneity of plpE gene in Indian isolates of Pasteurella multocida and expression of recombinant PlpE in vaccine strain of P. multocida serotype B: 2. J Vet Sci. 2010;11:227-33 pubmed
    ..coli and recombinant PlpE was strongly immunostained by antiserum against whole cell antigen, indicating that the protein is expressed in vivo...
  62. Lee J, Kim Y, Kwon M. Outer membrane protein H for protective immunity against Pasteurella multocida. J Microbiol. 2007;45:179-84 pubmed
    b>Pasteurella multocida, a Gram-negative facultative anaerobic bacterium, is a causative animal pathogen in porcine atrophic rhinitis and avian fowl cholera. For the development of recombinant subunit vaccine against P...
  63. Lax A. The Pasteurella multocida toxin: a new paradigm for the link between bacterial infection and cancer. Curr Top Microbiol Immunol. 2012;361:131-44 pubmed publisher
    ..A different approach is to assess bacteria for potentially pro-carcinogenic properties. The Pasteurella multocida toxin (PMT) has many properties that mark it out as a potential carcinogen...
  64. Brothers M, Ho M, Maharjan R, Clemons N, Bannai Y, Waites M, et al. Membrane interaction of Pasteurella multocida toxin involves sphingomyelin. FEBS J. 2011;278:4633-48 pubmed publisher
    b>Pasteurella multocida toxin (PMT) is an AB toxin that causes pleiotropic effects in targeted host cells...
  65. Harper M, Boyce J, Adler B. Pasteurella multocida pathogenesis: 125 years after Pasteur. FEMS Microbiol Lett. 2006;265:1-10 pubmed
    b>Pasteurella multocida was first shown to be the causative agent of fowl cholera by Louis Pasteur in 1881...
  66. Dagleish M, Hodgson J, Ataei S, Finucane A, Finlayson J, Sales J, et al. Safety and protective efficacy of intramuscular vaccination with a live aroA derivative of Pasteurella multocida B:2 against experimental hemorrhagic septicemia in calves. Infect Immun. 2007;75:5837-44 pubmed
    ..10(9), 10(8), and 10(7) CFU, respectively, of a derivative of Pasteurella multocida B:2 wild-type strain 85020 containing a deletion in the aroA gene (strain JRMT12)...
  67. Sthitmatee N, Numee S, Kawamoto E, Sasaki H, Yamashita K, Takahashi N, et al. Protection of chickens from fowl cholera by vaccination with recombinant adhesive protein of Pasteurella multocida. Vaccine. 2008;26:2398-407 pubmed publisher
    The recombinant adhesive protein (rCp39) of Pasteurella multocida strain P-1059 (serovar A:3) was prepared and purified with a hybrid condition of affinity chromatography...
  68. Blanchong J, Samuel M, Goldberg D, Shadduck D, Lehr M. Persistence of Pasteurella multocida in wetlands following avian cholera outbreaks. J Wildl Dis. 2006;42:33-9 pubmed
    Avian cholera, caused by Pasteurella multocida, affects waterbirds across North America and occurs worldwide among various avian species...
  69. Wilson B, Ho M. Recent insights into Pasteurella multocida toxin and other G-protein-modulating bacterial toxins. Future Microbiol. 2010;5:1185-201 pubmed publisher
    ..The dermonecrotic toxin from Pasteurella multocida (PMT) was recently added to the list of toxins that disrupt G-protein signal transduction through ..
  70. Verma S, Sharma M, Katoch S, Verma L, Kumar S, Dogra V, et al. Profiling of virulence associated genes of Pasteurella multocida isolated from cattle. Vet Res Commun. 2013;37:83-9 pubmed publisher
    b>Pasteurella multocida is a causative agent of many major diseases of which haemorrhagic septiciemia (HS) in cattle & a buffalo is responsible for significant losses to livestock sector in India and south Asia...
  71. Yu H, Chokhawala H, Karpel R, Yu H, Wu B, Zhang J, et al. A multifunctional Pasteurella multocida sialyltransferase: a powerful tool for the synthesis of sialoside libraries. J Am Chem Soc. 2005;127:17618-9 pubmed
    A multifunctional sialyltransferase has been cloned from Pasteurella multocida strain P-1059 and expressed in E. coli as a truncated C-terminal His6-tagged recombinant protein (tPm0188Ph)...
  72. Harper M, St Michael F, Vinogradov E, John M, Boyce J, Adler B, et al. Characterization of the lipopolysaccharide from Pasteurella multocida Heddleston serovar 9: identification of a proposed bi-functional dTDP-3-acetamido-3,6-dideoxy-?-D-glucose biosynthesis enzyme. Glycobiology. 2012;22:332-44 pubmed publisher
    b>Pasteurella multocida strains are classified into 16 different lipopolysaccharide (LPS) serovars using the Heddleston serotyping scheme...
  73. Harper M, Cox A, St Michael F, Parnas H, Wilkie I, Blackall P, et al. Decoration of Pasteurella multocida lipopolysaccharide with phosphocholine is important for virulence. J Bacteriol. 2007;189:7384-91 pubmed
    ..The lipopolysaccharide (LPS) structure of Pasteurella multocida strain Pm70, whose genome sequence is known, has recently been determined and does not contain PCho...
  74. Garcia N, Fernandez Garayzabal J, Goyache J, Dominguez L, Vela A. Associations between biovar and virulence factor genes in Pasteurella multocida isolates from pigs in Spain. Vet Rec. 2011;169:362 pubmed publisher
    Two hundred and five isolates of Pasteurella multocida from pigs were phenotypically and genetically characterised by determining their biovar, capsular type, virulence-associated genes and pulsed-field gel electrophoresis (PFGE) ..
  75. Preuss I, Hildebrand D, Orth J, Aktories K, Kubatzky K. Pasteurella multocida toxin is a potent activator of anti-apoptotic signalling pathways. Cell Microbiol. 2010;12:1174-85 pubmed publisher
    Toxigenic Pasteurella multocida strains produce a 146 kDa protein toxin (PMT) that due to its high mitogenic activity is thought to possess carcinogenic properties...
  76. Kim T, Lee J, Lee B. Development of a toxA gene knock-out mutant of Pasteurella multocida and evaluation of its protective effects. J Microbiol. 2006;44:320-6 pubmed
    b>Pasteurella multocida is an important veterinary and opportunistic human pathogen. In particular, strains of P. multocida serogroup D cause progressive atrophic rhinitis, and produce a potent, intracellular, mitogenic toxin known as P...
  77. Kawashima S, Matsukawa N, Ueki Y, Hattori M, Ojika K. Pasteurella multocida meningitis caused by kissing animals: a case report and review of the literature. J Neurol. 2010;257:653-4 pubmed publisher
  78. E komon T, Burchmore R, Herzyk P, Davies R. Predicting the outer membrane proteome of Pasteurella multocida based on consensus prediction enhanced by results integration and manual confirmation. BMC Bioinformatics. 2012;13:63 pubmed publisher
    Outer membrane proteins (OMPs) of Pasteurella multocida have various functions related to virulence and pathogenesis and represent important targets for vaccine development...
  79. Kitadokoro K, Kamitani S, Miyazawa M, Hanajima Ozawa M, Fukui A, Miyake M, et al. Crystal structures reveal a thiol protease-like catalytic triad in the C-terminal region of Pasteurella multocida toxin. Proc Natl Acad Sci U S A. 2007;104:5139-44 pubmed
    b>Pasteurella multocida toxin (PMT), one of the virulence factors produced by the bacteria, exerts its toxicity by up-regulating various signaling cascades downstream of the heterotrimeric GTPases Gq and G12/13 in an unknown fashion...
  80. Zamri Saad M, Ernie Z, Sabri M. Protective effect following intranasal exposure of goats to live Pasteurella multocida B:2. Trop Anim Health Prod. 2006;38:541-6 pubmed
    This study aimed to determine the effect of intranasal exposure to low doses of Pasteurella multocida B:2 on survival of goats challenged with high doses of the same organism. Eighteen goats were selected and divided into three groups...
  81. Babb R, Homer K, Robbins J, Lax A. Modification of heterotrimeric G-proteins in Swiss 3T3 cells stimulated with Pasteurella multocida toxin. PLoS ONE. 2012;7:e47188 pubmed publisher
    ..The Pasteurella multocida toxin (PMT) mediates its cellular effects through the activation of members of three of the four ..
  82. Wang C, Wu Y, Xing X, Hu G, Dai J, He H. An outbreak of avian cholera in wild waterfowl in Ordos wetland, Inner Mongolia, China. J Wildl Dis. 2009;45:1194-7 pubmed
    ..b>Pasteurella multocida was isolated from tissue samples of dead and sick birds and identified as P. multocida subsp...
  83. St Michael F, Harper M, Parnas H, John M, Stupak J, Vinogradov E, et al. Structural and genetic basis for the serological differentiation of Pasteurella multocida Heddleston serotypes 2 and 5. J Bacteriol. 2009;191:6950-9 pubmed publisher
    b>Pasteurella multocida is classified into 16 serotypes according to the Heddleston typing scheme...