mannheimia haemolytica

Summary

Summary: A species of gram-negative, facultatively anaerobic, rod-shaped bacteria normally commensal in the flora of CATTLE and SHEEP. But under conditions of physical or PHYSIOLOGICAL STRESS, it can cause MASTITIS in sheep and SHIPPING FEVER or ENZOOTIC CALF PNEUMONIA in cattle. Its former name was Pasteurella haemolytica.

Top Publications

  1. Ewers C, Lübke Becker A, Wieler L. [Mannheimia haemolytica and the pathogenesis of enzootic bronchopneumonia]. Berl Munch Tierarztl Wochenschr. 2004;117:97-115 pubmed
    ..Genome sequence analysis of M. haemolytica, enabling proteomics and transciptomics, hopefully will give new insight into the pathogenesis of pneumonic pasteurellosis. ..
  2. Tomassini L, Gonzales B, Weiser G, Sischo W. An ecologic study comparing distribution of Pasteurella trehalosi and Mannheimia haemolytica between Sierra Nevada bighorn sheep, White Mountain bighorn sheep, and domestic sheep. J Wildl Dis. 2009;45:930-40 pubmed
    ..Pasteurella trehalosi and Mannheimia haemolytica were detected in all of the study populations, but the relative proportion of each bacterial species ..
  3. Aulik N, Hellenbrand K, Kisiela D, Czuprynski C. Mannheimia haemolytica leukotoxin binds cyclophilin D on bovine neutrophil mitochondria. Microb Pathog. 2011;50:168-78 pubmed publisher
    b>Mannheimia haemolytica is an important member of the bovine respiratory disease (BRD) complex that causes fibrinous and necrotizing pleuropneumonia in cattle...
  4. Aulik N, Hellenbrand K, Klos H, Czuprynski C. Mannheimia haemolytica and its leukotoxin cause neutrophil extracellular trap formation by bovine neutrophils. Infect Immun. 2010;78:4454-66 pubmed publisher
    b>Mannheimia haemolytica is an important member of the bovine respiratory disease complex, which is characterized by abundant neutrophil infiltration into the alveoli and fibrin deposition...
  5. Griffin D, Chengappa M, Kuszak J, McVey D. Bacterial pathogens of the bovine respiratory disease complex. Vet Clin North Am Food Anim Pract. 2010;26:381-94 pubmed publisher
    ..b>Mannheimia haemolytica is the most common and serious of these bacterial agents and is therefore also the most highly ..
  6. Reeks B, Champlin F, Paulsen D, Scruggs D, Lawrence M. Effects of sub-minimum inhibitory concentration antibiotic levels and temperature on growth kinetics and outer membrane protein expression in Mannheimia haemolytica and Haemophilus somnus. Can J Vet Res. 2005;69:1-10 pubmed
    ..chlortetracycline-sulfamethazine (CTC + SMZ), on growth kinetics and outer membrane protein expression in Mannheimia haemolytica and Haemophilus somnus at normal and febrile body temperatures...
  7. Inamoto I, Lo R. Identification of putative two-component regulatory systems in the bovine pathogen Mannheimia haemolytica A1, and preliminary characterization of the NarQ/P system. FEMS Microbiol Lett. 2010;311:27-35 pubmed publisher
    The complete genome sequence of the bovine pathogen Mannheimia haemolytica A1 was analyzed by blast searches for the presence of two-component regulatory system proteins...
  8. Bavananthasivam J, Dassanayake R, Kugadas A, Shanthalingam S, Call D, Knowles D, et al. Proximity-dependent inhibition of growth of Mannheimia haemolytica by Pasteurella multocida. Appl Environ Microbiol. 2012;78:6683-8 pubmed publisher
    b>Mannheimia haemolytica, Pasteurella multocida, and Bibersteinia trehalosi have been identified in the lungs of pneumonic bighorn sheep (BHS; Ovis canadensis). Of these pathogens, M...
  9. Lawrence P, Shanthalingam S, Dassanayake R, Subramaniam R, Herndon C, Knowles D, et al. Transmission of Mannheimia haemolytica from domestic sheep (Ovis aries) to bighorn sheep (Ovis canadensis): unequivocal demonstration with green fluorescent protein-tagged organisms. J Wildl Dis. 2010;46:706-17 pubmed
    ..The objective of this study was to determine, unambiguously, whether Mannheimia haemolytica can be transmitted from domestic to bighorn sheep when they commingle. Four isolates of M...

More Information

Publications84

  1. Welsh R, Dye L, Payton M, Confer A. Isolation and antimicrobial susceptibilities of bacterial pathogens from bovine pneumonia: 1994--2002. J Vet Diagn Invest. 2004;16:426-31 pubmed
    Between 1994 and 2002, a total of 390 (46.3%) Mannheimia haemolytica, 292 (34.7%) Pasteurella multocida, and 160 (19...
  2. Barrallo S, Reglero A, Revilla Nuin B, Martínez Blanco H, Rodriguez Aparicio L, Ferrero M. Regulation of capsular polysialic acid biosynthesis by temperature in Pasteurella haemolytica A2. FEBS Lett. 1999;445:325-8 pubmed
    ..These findings indicate that the cellular growth temperature regulates the synthesis of these enzymes and hence the concentration of the intermediates necessary for capsular polysaccharide genesis in P. haemolytica A2. ..
  3. Kisiela D, Aulik N, Atapattu D, Czuprynski C. N-terminal region of Mannheimia haemolytica leukotoxin serves as a mitochondrial targeting signal in mammalian cells. Cell Microbiol. 2010;12:976-87 pubmed publisher
    b>Mannheimia haemolytica leukotoxin (LktA) is a member of the RTX toxin family that specifically kills ruminant leukocytes...
  4. Singh B, Pearce J, Gamage L, Janardhan K, Caldwell S. Depletion of pulmonary intravascular macrophages inhibits acute lung inflammation. Am J Physiol Lung Cell Mol Physiol. 2004;286:L363-72 pubmed
    ..These data may also be relevant to humans due to our ability to recruit PIMs. ..
  5. Gioia J, Qin X, Jiang H, Clinkenbeard K, Lo R, Liu Y, et al. The genome sequence of Mannheimia haemolytica A1: insights into virulence, natural competence, and Pasteurellaceae phylogeny. J Bacteriol. 2006;188:7257-66 pubmed
    The draft genome sequence of Mannheimia haemolytica A1, the causative agent of bovine respiratory disease complex (BRDC), is presented. Strain ATCC BAA-410, isolated from the lung of a calf with BRDC, was the DNA source...
  6. Marciel A, Highlander S. Use of operon fusions in Mannheimia haemolytica to identify environmental and cis-acting regulators of leukotoxin transcription. Infect Immun. 2001;69:6231-9 pubmed
    The leukotoxin of Mannheimia haemolytica is an important virulence factor that contributes to much of the pathology observed in the lungs of animals with bovine shipping fever pneumonia...
  7. Lo R, McKerral L, Hills T, Kostrzynska M. Analysis of the capsule biosynthetic locus of Mannheimia (Pasteurella) haemolytica A1 and proposal of a nomenclature system. Infect Immun. 2001;69:4458-64 pubmed
    ..haemolytica A1 nmaA/B genes resulted in the restoration of ECA biosynthesis. Region 3 contains two genes (wbrA and wbrB) which are suggested to be involved in the phospholipid modification of capsular materials...
  8. Roehrig S, Tran H, Spehr V, Gunkel N, Selzer P, Ullrich H. The response of Mannheimia haemolytica to iron limitation: implications for the acquisition of iron in the bovine lung. Vet Microbiol. 2007;121:316-29 pubmed
    b>Mannheimia haemolytica is the major causative agent of shipping fever, a severe pneumonia in cattle causing high morbidity and mortality. A prerequisite of successful lung colonization by M...
  9. Atapattu D, Czuprynski C. Mannheimia haemolytica leukotoxin binds to lipid rafts in bovine lymphoblastoid cells and is internalized in a dynamin-2- and clathrin-dependent manner. Infect Immun. 2007;75:4719-27 pubmed
    b>Mannheimia haemolytica is the principal bacterial pathogen of the bovine respiratory disease complex...
  10. Villard L, Gauthier D, Maurin F, Borges E, Richard Y, Abadie G, et al. Serotypes A1 and A2 of Mannheimia haemolytica are susceptible to genotypic, capsular and phenotypic variations in contrast to T3 and T4 serotypes of Bibersteinia (Pasteurella) trehalosi. FEMS Microbiol Lett. 2008;280:42-9 pubmed publisher
    b>Mannheimia haemolytica and Bibersteinia (Pasteurella) trehalosi are the most common bacterial isolates that cause pulmonary diseases in ruminants worldwide...
  11. Klima C, Alexander T, Read R, Gow S, Booker C, Hannon S, et al. Genetic characterization and antimicrobial susceptibility of Mannheimia haemolytica isolated from the nasopharynx of feedlot cattle. Vet Microbiol. 2011;149:390-8 pubmed publisher
    A surveillance study was undertaken to examine the population dynamics and antimicrobial resistance of Mannheimia haemolytica isolated from feedlot cattle...
  12. Jeyaseelan S, Sreevatsan S, Maheswaran S. Role of Mannheimia haemolytica leukotoxin in the pathogenesis of bovine pneumonic pasteurellosis. Anim Health Res Rev. 2002;3:69-82 pubmed
    ..The etiological agent, Mannheimia haemolytica, possesses several virulence factors, including capsule, outer membrane proteins, adhesins, neuraminidase, ..
  13. Leite F, Gyles S, Atapattu D, Maheswaran S, Czuprynski C. Prior exposure to Mannheimia haemolytica leukotoxin or LPS enhances beta(2)-integrin expression by bovine neutrophils and augments LKT cytotoxicity. Microb Pathog. 2003;34:267-75 pubmed
    ..The results of this study suggest that M. haemolytica LKT and LPS might cooperatively increase LFA-1 expression, and by so doing amplify the lung inflammation that characterizes bovine pasteurellosis. ..
  14. Zecchinon L, Fett T, Desmecht D. How Mannheimia haemolytica defeats host defence through a kiss of death mechanism. Vet Res. 2005;36:133-56 pubmed
    b>Mannheimia haemolytica induced pneumonias are only observed in goats, sheep and cattle. The bacterium produces several virulence factors,whose principal ones are lipopolysaccharide and leukotoxin...
  15. Leite F, O BRIEN S, Sylte M, Page T, Atapattu D, Czuprynski C. Inflammatory cytokines enhance the interaction of Mannheimia haemolytica leukotoxin with bovine peripheral blood neutrophils in vitro. Infect Immun. 2002;70:4336-43 pubmed
    ..The results of this study suggest that inflammatory cytokines may play an important role in enhancing the biological response of bovine PMNs to M. haemolytica LKT...
  16. Delis G, Koutsoviti Papadopoulou M, Siarkou V, Kounenis G, Batzias G. Pharmacodynamics of amoxicillin against Mannheimia haemolytica and Pasteurella multocida and pharmacokinetic/pharmacodynamic (PK/PD) correlation in sheep. Res Vet Sci. 2010;89:418-25 pubmed publisher
    ..Amoxicillin pharmacodynamics were studied in an artificial culture medium, SBS and TCF with use of a Mannheimia haemolytica and a Pasteurella multocida strain...
  17. Confer A, Ayalew S, Panciera R, Montelongo M, Wray J. Recombinant Mannheimia haemolytica serotype 1 outer membrane protein PlpE enhances commercial M. haemolytica vaccine-induced resistance against serotype 6 challenge. Vaccine. 2006;24:2248-55 pubmed
    b>Mannheimia haemolytica outer membrane protein PlpE, a major immunogenic outer membrane lipoprotein has identical sequences in serotypes 1 (S1) and S6. Recombinant outer membrane lipoprotein PlpE (rPLpE) from M...
  18. van der Vinne A, Lo R, Shewen P. Construction and analysis of a Mannheimia haemolytica A1 luxS mutant. Vet Microbiol. 2005;110:53-66 pubmed
    b>Mannheimia haemolytica A1 is the causative agent of bovine pneumonic pasteurellosis, a major cause of sickness, death, and economic loss to the feedlot cattle industry. M...
  19. Roier S, Fenninger J, Leitner D, Rechberger G, Reidl J, Schild S. Immunogenicity of Pasteurella multocida and Mannheimia haemolytica outer membrane vesicles. Int J Med Microbiol. 2013;303:247-56 pubmed publisher
    ..Together with Mannheimia haemolytica, P...
  20. Ismail M, El Kattan Y. Comparative pharmacokinetics of marbofloxacin in healthy and Mannheimia haemolytica infected calves. Res Vet Sci. 2007;82:398-404 pubmed
    The pharmacokinetics of marbofloxacin were investigated in healthy (n=8) and Mannheimia haemolytica naturally infected (n=8) Simmental ruminant calves following intravenous (i.v.) and intramuscular (i.m...
  21. Dassanayake R, Call D, Sawant A, Casavant N, Weiser G, Knowles D, et al. Bibersteinia trehalosi inhibits the growth of Mannheimia haemolytica by a proximity-dependent mechanism. Appl Environ Microbiol. 2010;76:1008-13 pubmed publisher
    ..These observations demonstrate that B. trehalosi can both outgrow and inhibit M. haemolytica growth with the latter related to a proximity- or contact-dependent mechanism...
  22. Zecchinon L, Fett T, Baise E, Desmecht D. Characterization of the caprine (Capra hircus) beta-2 integrin CD18-encoding cDNA and identification of mutations potentially responsible for the ruminant-specific virulence of Mannheimia haemolytica. Mol Membr Biol. 2004;21:289-95 pubmed
    ..identification of 16 potential mutation sites that could be held responsible for the unique virulence of Mannheimia haemolytica for ruminants...
  23. Hewson J, Viel L, Caswell J, Shewen P, Buchanan Smith J. Impact of isoflupredone acetate treatment on clinical signs and weight gain in weanling heifers with experimentally induced Mannheimia haemolytica bronchopneumonia. Am J Vet Res. 2011;72:1613-21 pubmed publisher
    To characterize the impact of Mannheimia haemolytica infection on feed intake and weight gain in feedlot heifers and to evaluate the clinical efficacy of isoflupredone acetate administered in combination with oxytetracycline.
  24. Angen O, Mutters R, Caugant D, Olsen J, Bisgaard M. Taxonomic relationships of the [Pasteurella] haemolytica complex as evaluated by DNA-DNA hybridizations and 16S rRNA sequencing with proposal of Mannheimia haemolytica gen. nov., comb. nov., Mannheimia granulomatis comb. nov., Mannheimia glucosida sp. Int J Syst Bacteriol. 1999;49 Pt 1:67-86 pubmed
    ..P.] haemolytica is reclassified as Mannheimia haemolytica comb. nov., whereas Pasteurella granulomatis, Bisgaard taxon 20 and [P...
  25. Davies R, Campbell S, Whittam T. Mosaic structure and molecular evolution of the leukotoxin operon (lktCABD) in Mannheimia (Pasteurella) haemolytica, Mannheimia glucosida, and Pasteurella trehalosi. J Bacteriol. 2002;184:266-77 pubmed
    ..The recombinational exchanges within the leukotoxin operon have had greatest effect on LktA and probably provide an adaptive advantage against the host antibody response by generating novel antigenic variation at surface-exposed sites...
  26. Aulik N, Hellenbrand K, Czuprynski C. Mannheimia haemolytica and its leukotoxin cause macrophage extracellular trap formation by bovine macrophages. Infect Immun. 2012;80:1923-33 pubmed publisher
    ..we reported that bovine neutrophils release NETs in response to the important respiratory pathogen Mannheimia haemolytica and its leukotoxin (LKT)...
  27. Ozawa M, Asai T, Sameshima T. Mutations in GyrA and ParC in fluoroquinolone-resistant Mannheimia haemolytica isolates from cattle in Japan. J Vet Med Sci. 2009;71:493-4 pubmed
    Nine isolates of Mannheimia haemolytica, comprising an enrofloxacin (ERFX)-resistant isolate, five nalidixic acid-resistant isolates and three susceptible isolates, from diseased cattle were subjected to sequence analysis of the quinolone ..
  28. Lawrence P, Dassanayake R. Ovis aries CR4 is involved in Mannheimia haemolytica leukotoxin-induced cytotoxicity. Vet Immunol Immunopathol. 2010;135:266-74 pubmed publisher
    Pneumonia caused by Mannheimia haemolytica is an important disease of domestic sheep (DS, Ovis aries) and cattle (BO). M...
  29. Step D, Krehbiel C, DePra H, Cranston J, Fulton R, Kirkpatrick J, et al. Effects of commingling beef calves from different sources and weaning protocols during a forty-two-day receiving period on performance and bovine respiratory disease. J Anim Sci. 2008;86:3146-58 pubmed publisher
  30. Aubry P, Warnick L, Guard C, Hill B, Witt M. Health and performance of young dairy calves vaccinated with a modified-live Mannheimia haemolytica and Pasteurella multocida vaccine. J Am Vet Med Assoc. 2001;219:1739-42 pubmed
    To evaluate the health and performance of young dairy calves vaccinated with a commercial Mannheimia haemolytica and Pasteurella multocida vaccine.
  31. Angen Ø, Ahrens P, Bisgaard M. Phenotypic and genotypic characterization of Mannheimia (Pasteurella) haemolytica-like strains isolated from diseased animals in Denmark. Vet Microbiol. 2002;84:103-14 pubmed
    ..The heterogeneity of species associated with bovine "pasteurellosis" should be considered in future studies to improve our understanding of the pathogenesis of pneumonic disease...
  32. Shanthalingam S, Srikumaran S. Intact signal peptide of CD18, the beta-subunit of beta2-integrins, renders ruminants susceptible to Mannheimia haemolytica leukotoxin. Proc Natl Acad Sci U S A. 2009;106:15448-53 pubmed publisher
    ..We propose that engineering cattle and other ruminants to contain this mutation would provide a novel technology to render them less susceptible to pneumonic pasteurellosis and concomitant economic losses...
  33. George J, Martin D, Lukacs P, Miller M. Epidemic pasteurellosis in a bighorn sheep population coinciding with the appearance of a domestic sheep. J Wildl Dis. 2008;44:388-403 pubmed
  34. Dassanayake R, Shanthalingam S, Herndon C, Subramaniam R, Lawrence P, Bavananthasivam J, et al. Mycoplasma ovipneumoniae can predispose bighorn sheep to fatal Mannheimia haemolytica pneumonia. Vet Microbiol. 2010;145:354-9 pubmed publisher
    ..ovipneumoniae alone causes fatal pneumonia in BHS, or predisposes them to infection by Mannheimia haemolytica. We chose M...
  35. Singh K, Ritchey J, Confer A. Mannheimia haemolytica: bacterial-host interactions in bovine pneumonia. Vet Pathol. 2011;48:338-48 pubmed publisher
    b>Mannheimia haemolytica serotype S1 is considered the predominant cause of bovine pneumonic pasteurellosis, or shipping fever. Various virulence factors allow M haemolytica to colonize the lungs and establish infection...
  36. Highlander S, Weissenberger S, Alvarez L, Weinstock G, Berget P. Complete nucleotide sequence of a P2 family lysogenic bacteriophage, varphiMhaA1-PHL101, from Mannheimia haemolytica serotype A1. Virology. 2006;350:79-89 pubmed
    The 34,525 nucleotide sequence of a double-stranded DNA bacteriophage (phiMhaA1-PHL101) from Mannheimia haemolytica serotype A1 has been determined. The phage encodes 50 open reading frames...
  37. Gånheim C, Hultén C, Carlsson U, Kindahl H, Niskanen R, Waller K. The acute phase response in calves experimentally infected with bovine viral diarrhoea virus and/or Mannheimia haemolytica. J Vet Med B Infect Dis Vet Public Health. 2003;50:183-90 pubmed
    ..The duration of elevated haptoglobin, SAA and fibrinogen values did not differ significantly within groups indicating that their value as indicator of disease is equal...
  38. Prado M, Prado T, Payton M, Confer A. Maternally and naturally acquired antibodies to Mannheimia haemolytica and Pasteurella multocida in beef calves. Vet Immunol Immunopathol. 2006;111:301-7 pubmed
    ..The dynamics and duration of maternally derived antibodies as well as the onset of acquired immunity against Mannheimia haemolytica and Pasteurella multocida in range-pastured beef calves were investigated...
  39. Katsuda K, Kohmoto M, Mikami O. Relationship between serotype and the antimicrobial susceptibility of Mannheimia haemolytica isolates collected between 1991 and 2010. Res Vet Sci. 2013;94:205-8 pubmed publisher
    The antimicrobial susceptibilities and serotype distribution of 310 Mannheimia haemolytica isolates obtained from cattle with bovine respiratory disease during 2002-2010 were investigated. Of the 310 isolates, 198 (63...
  40. Radi Z, Brogden K, Dixon R, Gallup J, Ackermann M. A selectin inhibitor decreases neutrophil infiltration during acute Mannheimia haemolytica pneumonia. Vet Pathol. 2002;39:697-705 pubmed
  41. Dassanayake R, Shanthalingam S, Herndon C, Lawrence P, Frances Cassirer E, Potter K, et al. Mannheimia haemolytica serotype A1 exhibits differential pathogenicity in two related species, Ovis canadensis and Ovis aries. Vet Microbiol. 2009;133:366-71 pubmed publisher
    b>Mannheimia haemolytica causes pneumonia in both bighorn sheep (BHS, Ovis canadensis) and domestic sheep (DS, Ovis aries). Under experimental conditions, co-pasturing of BHS and DS results in fatal pneumonia in BHS...
  42. Ayalew S, Blackwood E, Confer A. Sequence diversity of the immunogenic outer membrane lipoprotein PlpE from Mannheimia haemolytica serotypes 1, 2, and 6. Vet Microbiol. 2006;114:260-8 pubmed
    b>Mannheimia haemolytica serotype 1 (S1), S6 and S2 are the most common bacterial isolates found in shipping fever pneumonia in beef cattle. Currently used vaccines against M...
  43. Highlander S, Fedorova N, Dusek D, Panciera R, Alvarez L, Rinehart C. Inactivation of Pasteurella (Mannheimia) haemolytica leukotoxin causes partial attenuation of virulence in a calf challenge model. Infect Immun. 2000;68:3916-22 pubmed
    ..The wild-type and mutant strains were equally capable of colonizing the upper respiratory tracts of the calves. In this study, the P. haemolytica lktC mutant was shown to be less virulent than the parent strain...
  44. Ayalew S, Confer A, Hartson S, Shrestha B. Immunoproteomic analyses of outer membrane proteins of Mannheimia haemolytica and identification of potential vaccine candidates. Proteomics. 2010;10:2151-64 pubmed publisher
    Immunoproteomic analyses were used to characterize the outer membrane proteome of Mannheimia haemolytica, formerly Pasteurella haemolytica, serotype 1, and determine potential vaccine candidate proteins. 2-DE of M...
  45. Confer A, Ayalew S, Panciera R, Montelongo M, Whitworth L, Hammer J. Immunogenicity of recombinant Mannheimia haemolytica serotype 1 outer membrane protein PlpE and augmentation of a commercial vaccine. Vaccine. 2003;21:2821-9 pubmed
    b>Mannheimia haemolytica is the major cause of severe bacterial pneumonia associated with shipping fever in cattle. The gene for M. haemolytica outer membrane protein (OMP) PlpE was cloned into the expression vector pRSETA...
  46. Czuprynski C, Leite F, Sylte M, Kuckleburg C, Schultz R, Inzana T, et al. Complexities of the pathogenesis of Mannheimia haemolytica and Haemophilus somnus infections: challenges and potential opportunities for prevention?. Anim Health Res Rev. 2004;5:277-82 pubmed
    ..Our group has been involved in investigations of two members of the family Pasteurellaceae, Mannheimia haemolytica and Haemophilus somnus, which illustrate some of the complexities that must be confronted...
  47. Punpanich W, Srijuntongsiri S. Pasteurella (Mannheimia) haemolytica septicemia in an infant: a case report. J Infect Dev Ctries. 2012;6:584-7 pubmed
    ..Rare cases of systemic Mannheimia infections are reviewed and summarized...
  48. Lawrence P, Dassanayake R, Knowles D, Srikumaran S. Transfection of non-susceptible cells with Ovis aries recombinant lymphocyte function-associated antigen 1 renders susceptibility to Mannheimia haemolytica leukotoxin. Vet Microbiol. 2007;125:91-9 pubmed publisher
    b>Mannheimia haemolytica is an important etiological agent of pneumonia in domestic sheep (DS, Ovis aries)...
  49. Atapattu D, Albrecht R, McClenahan D, Czuprynski C. Dynamin-2-dependent targeting of mannheimia haemolytica leukotoxin to mitochondrial cyclophilin D in bovine lymphoblastoid cells. Infect Immun. 2008;76:5357-65 pubmed publisher
    ..One example of such a toxin is the potent leukotoxin (LKT) produced by the bovine respiratory pathogen Mannheimia haemolytica. LKT binds to CD18, resulting in the death of bovine leukocytes...
  50. Ackermann M, Gallup J, Zabner J, Evans R, Brockus C, Meyerholz D, et al. Differential expression of sheep beta-defensin-1 and -2 and interleukin 8 during acute Mannheimia haemolytica pneumonia. Microb Pathog. 2004;37:21-7 pubmed
    ..The effect of Mannheimia haemolytica, a Gram-negative bacteria known to induce expression of bovine beta-defensins and NF-kappa B in lung, has ..
  51. Lawrence P, Nelson W, Liu W, Knowles D, Foreyt W, Srikumaran S. beta(2) integrin Mac-1 is a receptor for Mannheimia haemolytica leukotoxin on bovine and ovine leukocytes. Vet Immunol Immunopathol. 2008;122:285-94 pubmed publisher
    Pneumonia caused by Mannheimia haemolytica is an important disease of cattle (BO), domestic sheep (DS, Ovis aries) and bighorn sheep (BHS, Ovis canadensis). Leukotoxin (Lkt) produced by M...
  52. McClenahan D, Hellenbrand K, Atapattu D, Aulik N, Carlton D, Kapur A, et al. Effects of lipopolysaccharide and Mannheimia haemolytica leukotoxin on bovine lung microvascular endothelial cells and alveolar epithelial cells. Clin Vaccine Immunol. 2008;15:338-47 pubmed
    Bovine respiratory disease resulting from infection with Mannheimia haemolytica commonly results in extensive vascular leakage into the alveoli. M...
  53. Nanduri B, Lawrence M, Vanguri S, Pechan T, Burgess S. Proteomic analysis using an unfinished bacterial genome: the effects of subminimum inhibitory concentrations of antibiotics on Mannheimia haemolytica virulence factor expression. Proteomics. 2005;5:4852-63 pubmed
    ..and chlortetracycline-sulfamethazine (CTC + SMZ), on protein expression in the bovine respiratory pathogen Mannheimia haemolytica. The M. haemolytica genome is currently in draft form, and annotation is incomplete...
  54. Confer A. Update on bacterial pathogenesis in BRD. Anim Health Res Rev. 2009;10:145-8 pubmed publisher
    b>Mannheimia haemolytica, Pasteurella multocida, Histophilus somni, Mycoplasma bovis and Arcanobacterium pyogenes are all frequently implicated in bovine respiratory disease (BRD). M...
  55. Portis E, Lindeman C, Johansen L, Stoltman G. A ten-year (2000-2009) study of antimicrobial susceptibility of bacteria that cause bovine respiratory disease complex--Mannheimia haemolytica, Pasteurella multocida, and Histophilus somni--in the United States and Canada. J Vet Diagn Invest. 2012;24:932-44 pubmed publisher
    Bovine isolates of Mannheimia haemolytica, Pasteurella multocida, and Histophilus somni, collected from 2000 to 2009, were tested for in vitro susceptibility to ceftiofur, penicillin, danofloxacin, enrofloxacin, florfenicol, tetracycline, ..
  56. Fulton R, Briggs R, Payton M, Confer A, Saliki J, Ridpath J, et al. Maternally derived humoral immunity to bovine viral diarrhea virus (BVDV) 1a, BVDV1b, BVDV2, bovine herpesvirus-1, parainfluenza-3 virus bovine respiratory syncytial virus, Mannheimia haemolytica and Pasteurella multocida in beef calves, antibody dec. Vaccine. 2004;22:643-9 pubmed
    ..Half of the vaccinated and unvaccinated calves also received one dose of an experimental Mannheimia haemolytica and Pasteurella multocida vaccine at day 95...
  57. Ayalew S, Shrestha B, Montelongo M, Wilson A, Confer A. Immunogenicity of Mannheimia haemolytica recombinant outer membrane proteins serotype 1-specific antigen, OmpA, OmpP2, and OmpD15. Clin Vaccine Immunol. 2011;18:2067-74 pubmed publisher
    We previously identified Mannheimia haemolytica outer membrane proteins (OMPs) that may be important immunogens by using immunoproteomic analyses...
  58. Thumbikat P, Dileepan T, Kannan M, Maheswaran S. Mechanisms underlying Mannheimia haemolytica leukotoxin-induced oncosis and apoptosis of bovine alveolar macrophages. Microb Pathog. 2005;38:161-72 pubmed
    ..LktA-induced apoptosis in alveolar macrophages involves activation of caspase-3 and engages the extrinsic and intrinsic pathways of apoptosis, with the extrinsic pathway being dependent on LFA-1 signaling and TNFalpha...
  59. Davies R, Lee I. Diversity of temperate bacteriophages induced in bovine and ovine Mannheimia haemolytica isolates and identification of a new P2-like phage. FEMS Microbiol Lett. 2006;260:162-70 pubmed
    The diversity of temperate bacteriophages was examined in 32 Mannheimia haemolytica, six Mannheimia glucosida and four Pasteurella trehalosi isolates. Phage particles were induced and identified by electron microscopy in 24 (75%) M...
  60. Highlander S, Wickersham E, Garza O, Weinstock G. Expression of the Pasteurella haemolytica leukotoxin is inhibited by a locus that encodes an ATP-binding cassette homolog. Infect Immun. 1993;61:3942-51 pubmed
    ..LapA is predicted to be the nucleotide-binding component of this transport system and shares homology with the Clp family of proteases...
  61. Hanzlicek G, White B, Mosier D, Renter D, Anderson D. Serial evaluation of physiologic, pathological, and behavioral changes related to disease progression of experimentally induced Mannheimia haemolytica pneumonia in postweaned calves. Am J Vet Res. 2010;71:359-69 pubmed publisher
    To determine the usefulness of physiologic, behavioral, and pathological changes as objective indicators of early respiratory disease in calves with Mannheimia haemolytica pneumonia.
  62. Huang R, Letendre L, Banav N, Fischer J, Somerville B. Pharmacokinetics of gamithromycin in cattle with comparison of plasma and lung tissue concentrations and plasma antibacterial activity. J Vet Pharmacol Ther. 2010;33:227-37 pubmed publisher
  63. Dassanayake R, Liu W, Davis W, Foreyt W, Srikumaran S. Bighorn sheep beta2-integrin LFA-1 serves as a receptor for Mannheimia haemolytica leukotoxin. J Wildl Dis. 2008;44:743-7 pubmed
    b>Mannheimia haemolytica is an important cause of pneumonia in bighorn sheep (BHS; Ovis canadensis). Leukotoxin (Lkt), the primary virulence determinant of M. haemolytica, induces cytolysis of all subsets of leukocytes...
  64. Leite F, Kuckleburg C, Atapattu D, Schultz R, Czuprynski C. BHV-1 infection and inflammatory cytokines amplify the interaction of Mannheimia haemolytica leukotoxin with bovine peripheral blood mononuclear cells in vitro. Vet Immunol Immunopathol. 2004;99:193-202 pubmed
    ..If such a mechanism occurs in vivo it might explain, in part, the increased susceptibility of BHV-1 infected cattle to bovine pasteurellosis...
  65. Mutoloki S, Ishii M, Narita M. Demonstration of bovine herpesvirus type 1 and Mannheimia haemolytica antigens in specimens stored for up to 22 months in buffered formalin. Can J Vet Res. 2002;66:60-3 pubmed
    Bovine herpesvirus type 1 (BHV-1) and Mannheimia haemolytica antigens were demonstrated in lung tissues that were stored in 10% neutral phosphate buffered formalin for 1 to 22 months using the immunoperoxidase method...
  66. Ayalew S, Confer A, Shrestha B, Wilson A, Montelongo M. Proteomic analysis and immunogenicity of Mannheimia haemolytica vesicles. Clin Vaccine Immunol. 2013;20:191-6 pubmed publisher
    b>Mannheimia haemolytica, a major causative agent in bovine respiratory disease, inflicts extensive losses each year on cattle producers. Commercially available vaccines are only partially efficacious. Immunity to M...
  67. Leite F, Atapattu D, Kuckleburg C, Schultz R, Czuprynski C. Incubation of bovine PMNs with conditioned medium from BHV-1 infected peripheral blood mononuclear cells increases their susceptibility to Mannheimia haemolytica leukotoxin. Vet Immunol Immunopathol. 2005;103:187-93 pubmed
  68. Daigneault M, Lo R. Analysis of a collagen-binding trimeric autotransporter adhesin from Mannheimia haemolytica A1. FEMS Microbiol Lett. 2009;300:242-8 pubmed publisher
    A locus that codes for a high-molecular-weight adhesin was previously isolated from Mannheimia haemolytica A1...
  69. Lawrence P, Kittichotirat W, McDermott J, Bumgarner R. A three-way comparative genomic analysis of Mannheimia haemolytica isolates. BMC Genomics. 2010;11:535 pubmed publisher
    ..haemolytica at molecular level and assist in devising an effective control strategy...
  70. Cudd L, Clarke C, Clinkenbeard K. Mannheimia haemolytica leukotoxin-induced increase in leukotriene B4 production by bovine neutrophils is mediated by a sustained and excessive increase in intracellular calcium concentration. FEMS Microbiol Lett. 2003;224:85-90 pubmed
    Isolated bovine neutrophils were used to study the relationship between the duration and magnitude of the Mannheimia haemolytica leukotoxin-induced increase in intracellular calcium concentration and leukotriene B4 synthesis...
  71. Lawrence P, Kittichotirat W, Bumgarner R, McDermott J, Herndon D, Knowles D, et al. Genome sequences of Mannheimia haemolytica serotype A2: ovine and bovine isolates. J Bacteriol. 2010;192:1167-8 pubmed publisher
    This report describes the genome sequences of Mannheimia haemolytica serotype A2 isolated from pneumonic lungs of two different ruminant species, one from Ovis aries, designated ovine (O), and the other from Bos taurus, designated bovine (..
  72. Angen O, Caugant D, Olsen J, Bisgaard M. Genotypic relationships among strains classified under the (Pasteurella) haemolytica-complex as indicated by ribotyping and multilocus enzyme electrophoresis. Zentralbl Bakteriol. 1997;286:333-54 pubmed
    ..Lineage F contained strains representing the leprine taxon 20 and the ruminant (P.) granulomatis. Ribotyping indicated that the ruminant biogroup 3J was affiliated with both taxon 20 and (P.) granulomatis...
  73. Dileepan T, Kannan M, Walcheck B, Maheswaran S. Integrin-EGF-3 domain of bovine CD18 is critical for Mannheimia haemolytica leukotoxin species-specific susceptibility. FEMS Microbiol Lett. 2007;274:67-72 pubmed
    b>Mannheimia haemolytica leukotoxin (LktA) is the primary virulence factor contributing to the pathogenesis of lung injury in bovine pneumonic pasteurellosis...
  74. Catry B, Dewulf J, de Kruif A, Vanrobaeys M, Haesebrouck F, Decostere A. Accuracy of susceptibility testing of Pasteurella multocida and Mannheimia haemolytica. Microb Drug Resist. 2007;13:204-11 pubmed
    ..In the present study, both aspects were investigated for 141 Pasteurella multocida and 34 Mannheimia haemolytica sensu lato isolates recovered from the upper respiratory tract of healthy calves...
  75. Highlander S. Molecular genetic analysis of virulence in Mannheimia (pasteurella) haemolytica. Front Biosci. 2001;6:D1128-50 pubmed
    b>Mannheimia haemolytica (previously known as Pasteurella haemolytica) is a weakly hemolytic, gram-negative coccobacillus that is an opportunistic pathogen of cattle, sheep and other ruminants...